METHOD FOR PRODUCING A CRYSTAL OF GLUTATHIONE IN REDUCED FORM
DE602017095144T2Active Publication Date: 2026-05-06KYOWA HAKKO BIO CO LTD
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Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- KYOWA HAKKO BIO CO LTD
- Filing Date
- 2017-03-10
- Publication Date
- 2026-05-06
AI Technical Summary
Technical Problem
Conventional methods struggle to effectively reduce the content of L-cysteinyl-L-glycine impurities in glutathione, which are known to generate free radicals and pose safety concerns, particularly in pharmaceutical and food applications where impurity levels need to be below 0.05%.
Method used
A method involving the use of a cation exchange resin with a high crosslinking degree to adsorb and remove L-cysteinyl-L-glycine from an aqueous solution containing reduced glutathione, followed by precipitation and collection of the crystal.
Benefits of technology
The method achieves a crystal of reduced glutathione with significantly reduced L-cysteinyl-L-glycine content, along with other impurities, meeting stringent safety standards for pharmaceutical and food applications.
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