Fluidic system and method for operating a fluidic system

Abstract

The invention relates to a fluidic system with a fluidic element and a transport device. The fluidic element comprises a basic body and a deformable membrane, the basic body comprising at least one first channel and at least one second channel for guiding a fluid, with at least one outlet being formed at one end of the first channel and at least one inlet being formed at one end of the second channel, and the membrane being connected to the basic body and covering at least the outlet of the first channel and the inlet of the second channel. The transport device comprises an actuator, the actuator being designed to deform the membrane such that a cavity is formed between the basic body and the membrane. The actuator comprises a magnetic shape memory alloy or consists thereof.

Description

[0001] Fluidic system and method for operating a fluidic system

[0002] Technical area

[0003] The invention relates to a fluidic system and a method for operating a fluidic system.

[0004] Technical background

[0005] Fluidic elements or microfluidic elements, such as lab-on-a-chip (LoC) elements, are increasingly being used to transport, treat, or analyze samples. One area of ​​application is point-of-care diagnostics (PoC). The fluidic elements can include a processing unit in which the sample undergoes a chemical, physical, or biological process. The fluidic elements or microfluidic elements can be used in insulin pumps or infusion pumps.

[0006] Typically, a very small fluid volume or flow rate (volume flow), possibly together with the sample and / or an active ingredient, is passed through the fluidic element. Precise dosing of very small fluid volumes is challenging, but important, for example, for LoC elements. Inaccuracies in the volume flow passed through the fluidic element can, for example, cause inaccuracies in the sample residence time in the LoC element, which can negatively impact an analysis.

[0007] The fluidic elements can be designed as single-use items, meaning they can be disposed of after a single use. The fluidic elements can be designed as disposable items. For this purpose, the fluidic elements are manufactured cost-effectively in large quantities.

[0008] The transport device by which a volume flow is provided through the fluidic element is considerably more cost-intensive than the fluidic element itself.

[0009] WO 2019 008 235 A1 discloses a microfluidic device comprising at least one magnetic shape memory material (MSM) element for handling a fluid flow, wherein the MSM element is controlled by a magnetic field. The device comprises elastic material between the fluid being handled and the MSM element, and the magnetic field is arranged to cause local shrinkage of the MSM element, which, together with the elastic material, forms a shrinkage cavity at a location where the magnetic field is applied to the MSM element. The microfluidic device can be connected to a lab-on-a-chip.

[0010] Summary of Revelation

[0011] One object of the invention is to provide a fluidic element that can be easily connected to a transport device for single use. A further object of the invention is to provide a fluidic system or a fluidic element that can be operated reliably and is cost-effective to manufacture. A still further object of the invention is to provide a fluidic system or a fluidic element through which a volume flow can be guided with relatively high precision and in which an actuator does not come into direct contact with the fluid guided through the fluidic element. A still further object of the invention is to provide a fluidic system or a fluidic element through which a volume flow can be guided relatively constantly.

[0012] A further object of the invention is to provide a fluidic system whose fluidic element can be easily connected to a transport device for single use.

[0013] At least one of the problems is solved by the combination of features of the independent claims.

[0014] A fluidic element is disclosed. The fluidic element comprises a base body with at least one first channel and at least one second channel for conducting a fluid. At least one outlet is formed at one end of the first channel. At least one inlet is formed at one end of the second channel. The fluidic element comprises a deformable membrane. The deformable membrane is connected to the base body. The deformable membrane covers at least the outlet of the first channel and the inlet of the second channel. The membrane can be deformed by an actuator in the direction of the actuator such that a movable cavity is formed between the base body and the membrane in order to transport the fluid from the outlet of the first channel to the inlet of the second channel.

[0015] The fluidic element can be a microfluidic element. In particular, the fluidic element is a lab-on-a-chip element. The fluidic element or the microfluidic element can be used in an insulin pump unit or in an infusion pump unit.

[0016] The base body of the fluidic element can comprise a plastic or be made of plastic. The base body of the fluidic element can comprise a metal or be made of metal. Likewise, the base body of the fluidic element can comprise a ceramic material or be made of a ceramic material.

[0017] The base body is preferably manufactured by injection molding. The base body can be an injection-molded part.

[0018] At least one first channel and one second channel can be formed in the base body. In addition to the first channel and the second channel, further channels can be formed in the base body. Each of the channels can be formed entirely in the base body. In particular, all sides of the channels are surrounded by the material of the base body, with an inlet and an outlet being formed in each case.

[0019] The channels can be embossed, milled or etched into the base body.

[0020] The channels may have a cross-sectional area (perpendicular to the flow direction through the respective channel) of a maximum of 2500 mm 2 , preferably maximum 2000 mm 2 , preferably not more than 1500 mm 2 , preferably not more than 1000 mm 2 , preferably a maximum of 500 mm 2 , preferably a maximum of 300 mm 2 , preferably not more than 100 mm 2 , preferably a maximum of 50 mm 2, preferably a maximum of 30 mm 2 , preferably not more than 1.0 mm 2 , preferably not more than 0.1 mm 2 , preferably not more than 0.01 mm 2 , preferably not more than 0.001 mm 2 ,. Particularly preferably, the channels have a cross-sectional area between 20 mm 2 and 0.0004 mm 2 on.

[0021] Each of the channels can be configured to carry a fluid. Generally, a fluid can be a gas or a liquid. The fluid can also be a mixture of a gas and a liquid. The fluid can contain a solid. The majority of the fluid (more than 50 vol%) can be liquid and / or gaseous.

[0022] The fluid may comprise a sample and / or an active ingredient. The sample and / or the active ingredient may be a solid, a liquid, and / or a gas. The sample may be a substance to be treated or analyzed, or a mixture of substances. During the treatment or analysis, the substance or mixture of substances may be subjected to at least one chemical, physical, and / or biological process. The active ingredient may be a substance that is administered to a living being (human or animal). The active ingredient may be used to treat the living being. For example, the active ingredient is insulin.

[0023] Each of the channels may comprise an inlet and an outlet. A fluid may be introduced into the channel through the inlet. The fluid may be discharged from the channel through the outlet. The flow direction may be defined from the inlet toward the outlet. Alternatively, the flow direction may be defined from the outlet toward the inlet. In other words, the flow direction may be reversible.

[0024] The membrane can be deformable, flexible, and / or elastic. The membrane can have a thickness that is many times smaller than its width and / or length. The thickness of the membrane can be a maximum of 2.0 mm, preferably a maximum of 1.0 mm, more preferably a maximum of 0.7 mm, more preferably a maximum of 0.5 mm, more preferably a maximum of 0.3 mm, more preferably a maximum of 0.2 mm, more preferably a maximum of 0.1 mm, more preferably a maximum of 0.01 mm. The thickness of the membrane is particularly preferably between 0.005 mm and 0.200 mm.

[0025] The membrane can have an area (perpendicular to the thickness of the membrane) of at least 1 mm 2 , preferably at least 10 mm 2 , preferably at least 50 mm 2 , preferably at least 100 mm 2 , preferably at least 300 mm 2 , preferably at least 500 mm 2 , preferably at least 1000 mm 2 , preferably at least 1500 mm 2 , preferably at least 2500 mm 2 , preferably at least 5000 mm 2 , preferably at least 10000 mm 2 , have.

[0026] The membrane can cover a maximum area of ​​10000 mm 2 , preferably not more than 1000 mm 2 , preferably a maximum of 200 mm 2 ,. The area of ​​the membrane is particularly preferably between 5 mm 2 and 200 mm 2 .

[0027] The membrane can be single-layer or multi-layered. The membrane can comprise a plastic or be made of plastic. The plastic can be a thermoplastic or an elastomer, in particular a thermoplastic elastomer. The membrane can comprise a metal or be made of metal. The membrane can comprise a composite material or be made of a composite material.

[0028] The membrane is connected to the base body. The connection between the membrane and the base body can be permanent. In particular, the connection between the membrane and the base body can be designed such that the membrane cannot be removed from the base body (without tools) without causing damage or destruction. Alternatively, the connection between the membrane and the base body can be designed such that the membrane can be removed from the base body without causing damage or destruction, in particular without tools.

[0029] In particular, the membrane is glued or welded to the base body. For example, the membrane can be welded to the base body using ultrasound or laser welding.

[0030] The membrane covers at least the outlet of the first channel and the inlet of the second channel. The membrane can completely overlie or cover at least the outlet of the first channel and the inlet of the second channel.

[0031] At least one side of the base body can have a planar or flat section. The outlet of the first channel and the inlet of the second channel can be formed in the section or open into the section. The membrane can be connected to the base body in the section. In particular, the area of ​​the planar or flat section is larger than the area of ​​the membrane.

[0032] The membrane can be deformed by an actuator in the direction of the actuator. In particular, the membrane can be deformed away from the base body. In other words, the membrane can be deformed by the actuator in such a way that a section of the membrane is lifted or lifted from the base body. A cavity can be formed between the base body and the membrane as a result of the deformation. The cavity can extend toward the actuator. The cavity can extend away from the base body.

[0033] The cavity may be formed at least temporarily in the region of the outlet of the first channel so that a fluid can flow from the outlet of the first channel into the cavity.

[0034] The cavity can be moved by the actuator, in particular in the direction of the inlet of the second channel. In particular, the cavity can be moved such that the cavity is not in fluid communication with the outlet of the first channel and with the inlet of the second channel. If the cavity is not in fluid communication with the outlet of the first channel and the inlet of the second channel, the fluid in the cavity can be (completely) separated or isolated from the environment. In other words, the cavity can be (completely) surrounded or enclosed by the base body and the membrane. By further moving the cavity in the direction of the inlet of the second channel, the cavity containing the fluid can come into fluid communication with the inlet of the second channel. The fluid can flow from the cavity into the second channel via the inlet of the second channel or be introduced. This allows a fluid to be transported from the first channel into the second channel.

[0035] The membrane can be connected to a surface of the base body via an attachment. The attachment can completely surround a surface section of the membrane.

[0036] The attachment can completely surround a surface section of the base body. The outlet of the first channel and the inlet of the second channel can be formed or open into the surface section of the base body that is completely surrounded by the attachment.

[0037] The attachment can be an adhesive seam or a welded seam.

[0038] A sample can be introduced into the fluidic element. The fluidic element can comprise a processing unit. The sample can be treated in the processing unit by a chemical, physical, and / or biological process. In particular, the sample can be analyzed in the processing unit by or with the aid of a chemical, physical, and / or biological process. The processing unit can comprise an assay, for example a biochemical assay or an immunoassay. Likewise, the processing unit can comprise a chromatographic element. In general, the processing unit can comprise one or more sensors.

[0039] The membrane can be connected to the base body in such a way that a portion of the membrane that is not deformed by the actuator contacts the base body.

[0040] If the membrane is not deformed by the actuator, the membrane can at least partially, in particular completely, rest against or contact the base body.

[0041] A fluidic system is disclosed. The fluidic system comprises a fluidic element and a transport device. The fluidic element comprises a base body and a deformable membrane. The base body comprises at least one first channel and at least one second channel for conducting a fluid or has at least the first channel and at least the second channel. At least one outlet is formed at one end of the first channel. At least one inlet is formed at one end of the second channel. The membrane is connected to the base body. The membrane covers at least the outlet of the first channel and the inlet of the second channel. The transport device comprises an actuator. The actuator is configured to deform the membrane so that a cavity is formed between the base body and the membrane.

[0042] The fluidic system may comprise any fluidic element disclosed herein. The fluidic system may be a microfluidic system.

[0043] The transport device can be a pumping device for transporting a liquid. Specifically, the transport device is a micropump device. A micropump device can have a maximum delivery capacity of 100 ml per minute, preferably 10 ml per minute, more preferably 5 ml per minute, and more preferably 1 ml per minute.

[0044] The actuator may comprise a magnetic shape memory alloy (MSMA) or be made of a magnetic shape memory alloy.

[0045] The shape of a magnetic shape memory alloy can be changed by applying a magnetic field. Twin boundaries in magnetic shape memory alloys are movable by a magnetic field, resulting in a magnetically induced reorientation of the material. A perpendicular magnetic field stretches the material, and a parallel magnetic field contracts it. The basic principle of a magnetic-field-induced deformation of an actuator made of a material with a twin boundary is described in US Pat. No. 6,515,382 B1, to which reference is made.

[0046] The magnetic shape memory alloy can be a nickel-manganese-gallium alloy. The actuator can be a pump actuator.

[0047] The actuator can essentially be cuboid-shaped.

[0048] The transport device may comprise a drive. The drive may be configured to deform the actuator. In particular, the drive is configured to generate a magnetic field.

[0049] The drive can generate a homogeneously directed magnetic traveling field. For this purpose, the drive comprises, in particular, electromagnetic coils and / or permanent magnets. Specifically, the drive can generate and move multiple magnetic traveling fields simultaneously.

[0050] A rotating magnetic field can be generated by the drive. For this purpose, the drive can comprise a magnet, in particular a diametrically magnetized magnet. The magnet can be rotatable. In particular, the drive is configured to rotate the magnet. The rotation can occur around a central axis of the magnet.

[0051] In general, the magnetic field can be oriented (at different times) perpendicular or parallel to the longitudinal extension of the actuator.

[0052] The transport device may comprise at least one sensor.

[0053] The transport device can comprise a temperature sensor that measures the temperature of the actuator. A control unit can change the operation of the transport device based on the value detected by the temperature sensor. In particular, the control unit can change the operation of the transport device if the temperature value of the actuator detected by the temperature sensor exceeds and / or falls below a specified temperature threshold. The transport device can comprise at least one pressure sensor that measures the pressure at the outlet of the first channel and / or at the inlet of the second channel. Based on the value detected by the at least one pressure sensor, the operation of the transport device can be changed (e.g., by a control unit).

[0054] The actuator and the membrane can be coupled in such a way that a deformation of the actuator causes a deformation of the membrane. In particular, the actuator and the membrane can be coupled in such a way that a deformation of the actuator causes a corresponding deformation of the membrane.

[0055] The actuator can be deformed by the drive of the transport device, in particular by generating a magnetic field through the drive. The actuator can be coupled or connected to the membrane in such a way that the deformation of the actuator is transmitted or passed on to the membrane. This allows the deformation of the membrane to be controlled or regulated by the drive.

[0056] The actuator can be connected to the membrane directly or indirectly. In particular, the actuator contacts the membrane directly or indirectly. In the case of indirect contact, an additional element, such as an adhesion promoter or an adhesion-promoting structure, can be present between the actuator and the membrane.

[0057] The actuator may have a greater length than a distance between the outlet of the first channel and an inlet of the second channel. The actuator may be arranged such that the actuator overlies or covers the outlet of the first channel and the inlet of the second channel.

[0058] The actuator can be connected to the membrane by an adhesive force. The adhesive force can couple or connect the actuator and the membrane in such a way that a deformation of the actuator causes or results in a (corresponding) deformation of the membrane.

[0059] The adhesive force can be provided by a fluid. The fluid can be present between the actuator and the membrane. Preferably, the fluid is silicone oil (e.g., diorganopolysiloxane). The fluid can have a higher viscosity than water. Likewise, the fluid can have a higher viscosity than the fluid that is to be conveyed or is being conveyed by the fluidic element.

[0060] In general, an adhesion film can be arranged between the actuator and the membrane. Both the actuator and the membrane can contact the adhesion film. An adhesion film can increase adhesion between the actuator and the membrane, especially compared to the adhesion between the actuator and the membrane without the adhesion film.

[0061] The adhesive force can be provided by an adhesion medium provided by breaking capsules between the actuator and the membrane.

[0062] For example, capsules can be arranged between the actuator and the membrane. The capsules can each comprise a shell that surrounds or encloses an adhesion medium. By pressing the actuator and the membrane together, the capsules can be broken or damaged, releasing the adhesion medium. The adhesion medium can provide the adhesive force between the actuator and the membrane. The adhesion medium can be a liquid, in particular silicone oil. The liquid can have a higher viscosity than water. Likewise, the liquid can have a higher viscosity than the fluid that is to be conveyed or is being conveyed by the fluidic element.

[0063] The adhesive force can be provided by a gel. The gel can be arranged between the actuator and the membrane. In particular, the adhesive force can be provided by a hydrocolloid film.

[0064] For example, a hydrocolloid can be provided between the actuator and the membrane. The hydrocolloid can be a polysaccharide or a protein. The hydrocolloid can adhere to the actuator or the membrane before the actuator and the membrane are brought into contact.

[0065] By adding a liquid, such as water, the hydrocolloid can form a hydrocolloid film between the actuator and the membrane. The actuator can be bonded to the membrane. An adhesive can be arranged between the actuator and the membrane, connecting the actuator to the membrane. The bond can be removable. Alternatively, the bond can be designed in such a way that the connection between the actuator and the membrane cannot be removed non-destructively or without causing damage (without aids). For example, the bond can be designed in such a way that it is weakened by heating. The bond can be designed in such a way that it can be removed by heating. Without heating, the connection between the actuator and the membrane cannot be removed non-destructively or without causing damage.

[0066] The bond can be provided by an adhesive film between the actuator and the membrane. The adhesive film can be understood as an adhesive or bonding agent. For example, an adhesive film can be applied in an unsolidified form between the actuator and the membrane. The adhesive film can solidify between the actuator and the membrane. This can provide the connection between the actuator and the membrane.

[0067] The adhesive film can be an elastic adhesive. This allows the actuator to be removed or detached from the membrane without causing any damage.

[0068] The bond can be provided by an adhesive membrane between the actuator and the membrane. An adhesive membrane can comprise a non-sticky carrier and an adhesive or bonding agent. The adhesive or bonding agent of the adhesive membrane can be non-solidified or cannot be solidified.

[0069] For example, the membrane can be coated with an adhesive or bonding agent on one side. The adhesive or bonding agent can be uncured or uncured. When the actuator is pressed against the membrane, the adhesive or bonding agent creates a bond between the actuator and the membrane. The actuator can be removed or detached from the membrane without causing any damage.

[0070] Likewise, a two-sided adhesive membrane can be provided between the actuator and the membrane. An adhesive or bonding agent can be provided on both (flat) sides of the adhesive membrane. Preferably, the adhesive strength of the adhesive or bonding agent is greater on one side of the adhesive membrane than on the other (opposite) side of the adhesive membrane. The two-sided adhesive membrane can be arranged between the actuator and the membrane, and the actuator can be pressed onto the membrane. This allows the actuator to be connected to the membrane. The actuator can be removed or detached from the membrane without causing any damage or destruction.

[0071] The actuator can be connected to the membrane by van der Waals forces and / or electrostatic forces. In particular, the actuator and / or the membrane has a plurality of adhesive elements. Alternatively, a further membrane with a plurality of adhesive elements can be arranged between the actuator and the membrane. The further membrane can comprise a plurality of adhesive elements on both (flat) sides.

[0072] If the actuator and the membrane are brought into contact (possibly with a membrane in between), van der Waals forces and / or electrostatic forces can increase between the actuator and the membrane (gecko effect). This allows the actuator to be bonded to the membrane. The actuator can be removed or detached from the membrane without causing any damage or destruction.

[0073] The actuator can be connected to the membrane by a vacuum. A vacuum can exist between the actuator and the membrane. The vacuum can be lower than the ambient pressure, in particular lower than 1 bar. For this purpose, the fluidic element and / or the transport device can comprise a vacuum unit. The vacuum unit can also be provided outside the fluidic element and the transport device. The vacuum unit can generate a vacuum between the actuator and the membrane.

[0074] Preferably, the connection between the actuator and the membrane is pressure-tight. This pressure-tight connection allows a negative pressure to be maintained between the actuator and the membrane.

[0075] The actuator can be connected to the membrane by a magnetic force. The membrane can be magnetic. In particular, the membrane is ferromagnetic. The actuator can be magnetic. If the actuator and the membrane are brought into contact, a connection between the actuator and the membrane can be established by a magnetic force. The actuator can be removed or detached from the membrane without causing any damage or destruction.

[0076] In particular, the membrane is multi-layered or multi-ply. The membrane can comprise at least one magnetic, preferably at least one ferromagnetic, layer or ply. For example, the magnetic layer or ply can be located closer to the side of the membrane that is or comes into contact with the actuator than to the side of the membrane that is or comes into contact with the fluid. The side of the membrane that is or comes into contact with the fluid can not comprise or be a magnetic layer or ply. In particular, the side of the membrane that is or comes into contact with the fluid is resistant to the fluid.

[0077] A method for operating a fluidic system is disclosed. The method comprises the steps of: deforming a membrane connected to a base body by an actuator in the direction of the actuator, so that a cavity forms between the base body and the membrane; introducing a fluid from an outlet of a first channel of the base body into the cavity; moving the cavity with the fluid by the actuator toward an inlet of a second channel; and introducing the fluid into the second channel via the inlet.

[0078] The fluidic system can be any fluidic system disclosed herein. Any fluidic element disclosed herein can be used in the method. Any transport device disclosed herein can be used in the method.

[0079] The actuator may comprise or consist of a magnetic shape memory alloy.

[0080] In general, the actuator or transport device can be detachably connected or combined with the membrane. This allows the fluidic element to be disposed of after a single use (disposable item) and another fluidic element to be connected or used with the actuator or transport device. By designing the fluidic element as a disposable item, cross-contamination can be avoided and / or sterile operation can be ensured. The actuator and / or transport device can therefore be reusable. The actuator or transport device can be connected to the membrane or fluidic element using a snap connection, a screw connection, a clamping mechanism, a pliers mechanism, a bayonet lock, and / or an adhesive connection.

[0081] Likewise, the actuator or transport device can be firmly, i.e. non-detachably, connected to the membrane or the fluidic element.

[0082] The membrane can be attached to the base body of the fluidic element in such a way that the actuator does not come into contact with the fluid when a fluid is transported from the outlet of the first channel to the inlet of the second channel. The membrane can act or function as a media separator.

[0083] The membrane can be deformed (simultaneously) in at least two different sections by the actuator. Between the membrane and the base body, at least two cavities can be formed (simultaneously) by the actuator.

[0084] Short description of the characters

[0085] The disclosure and further embodiments and advantages of the disclosure are explained in more detail below with reference to figures, wherein the figures merely describe exemplary embodiments of the disclosure. Identical components in the figures are provided with the same reference numerals. In the figures:

[0086] Fig. 1 a fluidic system 1000;

[0087] Fig. 2a a fluidic element 100 at a first time;

[0088] Fig. 2b the fluidic element 100 at a second time;

[0089] Fig. 2c the fluidic element 100 at a third time;

[0090] Fig. 3 a transport device 200;

[0091] Fig. 4 shows a section of a fluidic system 1000;

[0092] Fig. 5 shows a section of a fluidic system 1000; Fig. 6 shows a section of a fluidic system 1000;

[0093] Fig. 7 shows a section of a fluidic system 1000; and

[0094] Fig. 8 shows a section of a fluidic system 1000.

[0095] Detailed description

[0096] Fig. 1 shows a fluidic system 1000. The fluidic system may be a microfluidic system 1000. The fluidic system 1000 comprises a fluidic element 100 and a transport device 200. The fluidic element 100 and the transport device 200 are described in more detail with reference to Figs. 2a to 2c and 3 below.

[0097] The fluidic element 100 may comprise a base body 110. At least two channels may be formed in the base body 100. The fluidic element 100 may comprise a membrane 120. The membrane 120 may be applied to a surface of the base body 110.

[0098] The transport device 200 can comprise an actuator 210. The actuator 210 can comprise or consist of a magnetic shape memory alloy. The transport device 200 can comprise a drive 220. The drive 220 can be configured to generate a homogeneously directed magnetic traveling field. The magnetic field is indicated in Fig. 1 by four parallel arrows directed in the direction of the base body 110. Likewise, the drive 220 can be configured to generate a rotating magnetic field. The magnetic field of the drive 220 can deform the actuator 210. In particular, a constriction or taper can be formed in at least one surface of the actuator 210.

[0099] The fluidic element 100 can be connected to the transport device 200. In particular, the fluidic element 100 can be connected to the transport device 200 such that the actuator 210 is coupled or connected to the membrane 120. The connection or coupling can be made via a contact region 300. The actuator 210 and the membrane 120 can be coupled or connected to one another such that a deformation of the actuator 210 causes a (corresponding) deformation of the membrane 120. If, for example, a constriction or taper is formed in the actuator 210, the membrane 120 can be deformed toward the actuator 210. In particular, the membrane 120 is deformed away from the base body 110 or lifted or lifted off the base body 110 when the actuator 210 is deformed.

[0100] By deforming the membrane 120, a cavity 131 can be formed between the membrane 120 and the base body 110. A fluid can be transported in the cavity 131. The fluid can be transported by the magnetic field generated by the drive and the deformation of the actuator 210. If the deformation of the actuator 210 changes, the deformation of the membrane 120 can also change, causing the cavity 131 to change.

[0101] In a region where no deformation is formed in the actuator 210, the membrane 120 may be undeformed. In this state, the membrane 120 may be in contact with the base body 110. When the membrane 120 is in contact with the base body 110, no fluid may be present between the membrane 120 and the base body 110 in this region.

[0102] The transport device 200 may include a housing 221. The drive 220 may be at least partially incorporated into the housing 221 of the transport device 200. The actuator 210 may be at least partially incorporated into the housing 221 of the transport device 200.

[0103] In Figs. 2a to 2c, a fluidic element 100 is shown at three different times.

[0104] Fig. 2a shows the fluidic element 100 at a first point in time. The fluidic element 100 may comprise a base body 110. At least one first channel 151 and at least one second channel 154 may be formed in the base body 110. The base body may be an injection-molded part. The first channel 151 and the second channel 154 may have been formed in the base body 110 during the injection-molding process.

[0105] Fluid can be introduced into the first channel 151 via an inlet 150. An outlet 152 can be formed at one end of the first channel 151. The outlet 152 can open into a surface of the base body 110 or be formed therein. The outlet 152 of the first channel 151 can be covered or overlaid by the membrane 120. The fluidic element 100 can comprise at least one second channel 154. The second channel 154 can be formed in the base body. The second channel 154 can comprise an outlet 155. A fluid can exit or be discharged from the outlet 155 of the second channel 154. An inlet 153 can be formed at one end of the second channel 154. The inlet 153 of the second channel 154 can be formed in a surface of the base body 110 or open therein. The inlet 153 of the second channel 154 may be overlaid or covered by the membrane 120.

[0106] The inlet 153 of the second channel 154 can be formed or open into the same side of the base body 110 as the outlet 152 of the first channel 151. In particular, the inlet 153 of the second channel 154 and the outlet 152 of the first channel 151 are formed or open into a surface portion of the base body 110 that is planar, flat, or plane.

[0107] The membrane 120 can be attached to the side of the base body 110 in which the inlet 153 of the second channel 154 and the outlet 152 of the first channel 151 are formed or open into.

[0108] The membrane 120 may include an attachment 121 (also referred to as a fastening). The attachment 121 may completely surround a surface portion of the membrane 120 and / or the base body 110. The attachment 121 may be an adhesive bond, a bond seam, a weld, and / or a weld seam. For example, the membrane 120 is adhesively bonded or welded to the base body 110.

[0109] The fluidic element 110 may include a processing unit 160. A sample may be treated or analyzed in the processing unit 160. For example, the processing unit 160 may be arranged upstream of the outlet 152 of the first channel 151. Likewise, the processing unit 160 may be arranged downstream of the inlet 153 of the second channel 154.

[0110] A sample can flow with a fluid through the first and / or second channel 151, 154 to be treated or analyzed in the processing unit 160. The sample can be subjected to a chemical, physical and / or biological process by the processing unit 160. At the first point in time (see Fig. 2a), the membrane 120 is deformed in the region of the outlet 152 of the first channel 151. The deformation of the membrane 120 is caused by the actuator 210 (not shown in Fig. 2a). Due to the deformation, a cavity 131 can form between the membrane 120 and the base body 110. At the point in time in Fig. 2a, the cavity is in fluid communication with the cavity 131, so that fluid can flow from the first channel 151 into the cavity 131 via the outlet 152 of the first channel 151. By forming the cavity 131, a (slight) negative pressure can be generated, causing the fluid to flow into the cavity 131.Likewise, fluid can flow into the inlet 150 of the first channel 151.

[0111] Fig. 2b shows the fluidic element 100 as described with reference to Fig. 2a at a second time. At the second time, the cavity 131, filled with fluid, has been moved toward the inlet 153 of the second channel 154. The movement of the cavity 131 can be caused by a movement of the deformation in the actuator 210 (not shown in Fig. 2b). The movement of the deformation in the actuator 210 can be caused by a movement or change in the magnetic field generated by the drive 220.

[0112] At the second time, the outlet 152 of the first channel 151 may not be in fluid communication with the cavity 131. At the second time, the inlet 153 of the second channel 154 may not be in fluid communication with the cavity 131. The cavity 131 containing the fluid may be completely enclosed or surrounded by the membrane 120 and the base body 110. In particular, the actuator 210 may press the membrane 120 against the base body 110 or toward the base body 110 in a region outside the cavity 131.

[0113] Fig. 2c shows the fluidic element 100 as described with reference to Fig. 2a at a third point in time. At the third point in time, the cavity 131, filled with fluid, has been moved into the region of the inlet 153 of the second channel 154. The movement of the cavity 131 can be caused by a movement of the deformation in the actuator 210 (not shown in Fig. 2c). The movement of the deformation in the actuator 210 can be brought about by a movement or change in the magnetic field generated by the drive 220. At the third point in time, the cavity 131 can be in fluid communication with the inlet 153 of the second channel 154. As a result, fluid can flow from the cavity 131 into the second channel 154 via the inlet 153 of the second channel 154. Likewise, fluid can flow out of the outlet 155 of the second channel 154.

[0114] Fig. 3 shows a transport device 200. The transport device 200 may include an actuator 210. In particular, the actuator 210 comprises or consists of a magnetic shape memory alloy.

[0115] The transport device 200 can include a drive 220. The drive 220 can be configured to generate a magnetic field. The magnetic field can be a homogeneously directed magnetic traveling field. A deformation 211 can be formed in the actuator 210 by the magnetic field. The deformation 211 can be a constriction or a tapered portion. The membrane 120 can be deformed by the deformation 211 of the actuator 210.

[0116] The drive 220 can include a plurality of electromagnetic coils 222. The electromagnetic coils 222 can be arranged along the actuator 210. The electromagnetic coils 222 can be controlled or regulated such that a magnetic field travels along the actuator 210. The traveling magnetic field can cause the deformation 211 to travel in the actuator 210.

[0117] The drive 220 can comprise at least one magnet 223, in particular a diametrical magnet. With a diametrical magnet, the magnet axis runs through the diameter. The poles on the magnetic surfaces are opposite each other. The magnet 223 can be controlled or regulated such that a magnetic field travels along the actuator 210.

[0118] Fig. 4 shows a section of a fluidic system 1000, as indicated in Fig. 1.

[0119] A contact region 300 can be formed between the actuator 210 and the membrane 120. The contact region 300 can establish or strengthen a connection between the actuator 210 and the membrane 120. For example, the contact region 300 can provide an adhesive force between the actuator 210 and the membrane. Likewise, a bond between the actuator 210 and the membrane 120 can be provided in the contact region 300. A liquid, e.g., silicone oil, can be provided in the contact region 300 between the actuator 210 and the membrane 120. The liquid can establish or strengthen an adhesive force between the actuator 210 and the membrane.

[0120] An adhesive bond may be provided between the actuator 210 and the membrane 120 in the contact area 300. The adhesive bond may be provided by an adhesive film or an adhesive membrane. The adhesive membrane may be a single-sided or double-sided adhesive membrane.

[0121] A gel may be provided in the contact area 300. Preferably, a hydrocolloid film is provided in the contact area 300.

[0122] Fig. 5 shows a section of a fluidic system 1000, as indicated in Fig. 1.

[0123] Capsules 310 can be arranged between the actuator 210 and the membrane 120. The capsules 310 can each have a shell. The shell can contain an adhesion medium. If the actuator 210 is pressed or pushed against the membrane 120, the capsule's shell can be damaged or ruptured. This allows the adhesion medium to escape from the interior of the capsule and enter between the actuator 210 and the membrane 120. The adhesion medium can provide an adhesive force between the actuator 210 and the membrane 120.

[0124] Figs. 6 and 7 show a section of a fluidic system 1000, as indicated in Fig. 1.

[0125] Adhesive elements 320 can be arranged between the actuator 210 and the membrane 120. The adhesive elements 320 can cause or increase van der Waals forces and / or electrostatic forces between the actuator 210 and the membrane 120. A plurality of adhesive elements 320 can be provided between the actuator and the membrane 120, for example, at least 100, preferably at least 500, more preferably at least 1000 adhesive elements 320.

[0126] The adhesive elements 320 can be provided on the membrane 120. In particular, the membrane 120 can comprise the adhesive elements 320. The adhesive elements 320 can be firmly connected to the membrane 120. Likewise, the adhesive elements 320 can be provided on the actuator 210. In particular, the actuator 210 can comprise the adhesive elements 320. The adhesive elements 320 can be firmly connected to the actuator 210.

[0127] An adhesive membrane 215 can be provided between the actuator 210 and the membrane 120 (see Fig. 7). The adhesive membrane 215 can comprise the adhesive elements 320. In particular, the adhesive elements 320 can be firmly connected to the adhesive membrane 215. The adhesive membrane 215 can be firmly or detachably connected to the transport device 200, in particular to the actuator 210 or to the housing 221 of the transport device 200. Likewise, the adhesive membrane 215 can be firmly or detachably connected to the fluidic element 100, in particular to the membrane 120 or to the base body 110.

[0128] Fig. 8 shows a section of a fluidic system 1000, as indicated in Fig. 1.

[0129] A magnetic force can act between the actuator 210 and the membrane 120. For example, the membrane can be magnetic or magnetizable. Preferably, the membrane 120 has a ferromagnetic property or is ferromagnetic. The actuator 210 can be magnetic or magnetizable.

[0130] Numbered examples of the revelation are given below:

[0131] 1. Fluidic element (100) comprising: a base body (110) with at least one first channel (151) and at least one second channel (154) for guiding a fluid, wherein at least one outlet (152) is formed at one end of the first channel (151) and at least one inlet (153) is formed at one end of the second channel (154); and a deformable membrane (120) connected to the base body (110) and covering at least the outlet (152) of the first channel (151) and the inlet (153) of the second channel (154), wherein the membrane (120) is deformable by an actuator (210) in the direction of the actuator (110) such that a movable cavity (131) is formed between the base body (110) and the membrane (120) to transport the fluid from the outlet (152) of the first channel (151) to the inlet (153) of the second channel (154). 2.Fluidic element according to example 1, wherein the membrane (120) is connected to a surface of the base body (110) via an attachment (121) and the attachment (121) completely surrounds a surface section of the membrane (120).

[0132] 3. Fluidic element according to example 1 or 2, wherein a sample can be introduced into the fluidic element (100) and wherein the fluidic element (100) comprises a processing unit (160), wherein the sample can be treated in the processing unit (160) by a chemical, physical and / or biological process.

[0133] 4. Fluidic element according to one of examples 1 to 3, wherein the membrane (120) is connected to the base body (110) such that a portion of the membrane (120) which is not deformed by the actuator (110) contacts the base body (110).

[0134] 5.A fluidic system (1000) comprising a fluidic element (100), in particular comprising a fluidic element (100) according to one of the preceding examples, and a transport device (200), wherein: the fluidic element (100) comprises a base body (110) and a deformable membrane (120), wherein the base body (110) comprises at least one first channel (151) and at least one second channel (154) for guiding a fluid, wherein at least one outlet (152) is formed at one end of the first channel (151) and at least one inlet (153) is formed at one end of the second channel (154), wherein the membrane (120) is connected to the base body and covers at least the outlet (152) of the first channel (151) and the inlet (153) of the second channel (154); the transport device (200) comprises an actuator (210), wherein the actuator (210) is configured to deform the membrane (120) so that a cavity (131) is formed between the base body (110) and the membrane (120).

[0135] 6. The fluidic system (1000) according to example 5, wherein the actuator (210) comprises or consists of a magnetic shape memory alloy.

[0136] 7. Fluidic system (1000) according to example 5 or 6, wherein the transport device (200) comprises a drive (220), wherein the drive (220) is configured to deform the actuator (210), in particular wherein the drive (220) is configured to generate a magnetic field.

[0137] 8. Fluidic system (1000) according to one of examples 5 to 7, wherein the actuator (210) and the membrane (120) are coupled to one another such that a deformation of the actuator (210) causes a deformation of the membrane, in particular that a deformation of the actuator (210) causes a corresponding deformation of the membrane (120).

[0138] 9. The fluidic system (1000) according to any one of examples 5 to 8, wherein the actuator (210) is connected to the membrane (120) by an adhesive force.

[0139] 10. Fluidic system (1000) according to example 9, wherein the adhesive force is provided by a fluid, preferably a liquid, more preferably silicone oil, between the actuator (210) and the membrane (120).

[0140] 11. The fluidic system (1000) of example 9, wherein the adhesive force is provided by an adhesion medium provided by breaking capsules between the actuator (210) and the membrane (120).

[0141] 12. Fluidic system (1000) according to example 9, wherein the adhesive force is provided by a gel, in particular by a hydrocolloid film, between the actuator (210) and the membrane (120).

[0142] 13. Fluidic system (1000) according to one of examples 5 to 8, wherein the actuator (210) is connected to the membrane (120) by an adhesive bond.

[0143] 14. The fluidic system (1000) according to example 13, wherein the bonding is provided by an adhesive film between the actuator (210) and the membrane (120) or wherein the bonding is provided by an adhesive membrane between the actuator (210) and the membrane (120).

[0144] 15. The fluidic system (1000) according to any one of examples 5 to 8, wherein the actuator (210) is connected to the membrane (120) by van der Waals forces and / or electrostatic forces, in particular wherein the actuator (210) and / or the membrane (120) has a plurality of adhesive elements (320).

[0145] 16. Fluidic system (1000) according to one of examples 5 to 8, wherein the actuator (210) is connected to the membrane (120) by a vacuum.

[0146] 17. The fluidic system (1000) according to any one of examples 5 to 8, wherein the actuator (210) is connected to the membrane (120) by a magnetic force, in particular wherein the membrane (120) is magnetic.

[0147] 18. Method for operating a fluidic system (1000), in particular a fluidic system (1000) according to one of examples 5 to 17, the method comprising the steps:

[0148] Deforming a membrane (120) connected to a base body (110) by an actuator (210) in the direction of the actuator (210) so that a cavity (131) is formed between the base body (110) and the membrane (120);

[0149] Introducing a fluid from an outlet (152) of a first channel (151) of the base body (110) into the cavity (131);

[0150] Moving the cavity (131) with the fluid through the actuator (210) towards an inlet (153) of a second channel (154);

[0151] Introducing the fluid into the second channel (154) via the inlet (153).

[0152] 19. The method of example 18, wherein the actuator (210) comprises or consists of a magnetic shape memory alloy.

Claims

Claims 1.Fluidic system (1000) with a fluidic element (100) and a transport device (200), wherein: the fluidic element (100) comprises a base body (110) and a deformable membrane (120), wherein the base body (110) comprises at least a first channel (151) and at least a second channel (154) for guiding a fluid, wherein at least an outlet (152) is formed at one end of the first channel (151) and at least an inlet (153) is formed at one end of the second channel (154), wherein the membrane (120) is connected to the base body and covers at least the outlet (152) of the first channel (151) and the inlet (153) of the second channel (154); the transport device (200) comprises an actuator (210) wherein the actuator (210) is configured to deform the membrane (120) so that a cavity (131) is formed between the base body (110) and the membrane (120), wherein the actuator (210) comprises or consists of a magnetic shape memory alloy.

2. Fluidic system (1000) according to claim 1, wherein the actuator (210) is detachably connectable to the membrane (120).

3. Fluidic system (1000) according to claim 1 or 2, wherein the transport device (200) comprises a drive (220), wherein the drive (220) is configured to deform the actuator (210), in particular wherein the drive (220) is configured to generate a magnetic field.

4. Fluidic system (1000) according to one of the preceding claims, wherein the actuator (210) and the membrane (120) are coupled together such that a deformation of the actuator (210) causes a deformation of the membrane, in particular that a deformation of the actuator (210) causes a corresponding deformation of the membrane (120).

5. Fluidic system (1000) according to one of the preceding claims, wherein the actuator (210) is connected to the membrane (120) by an adhesive force. Fluidic system (1000) according to claim 5, wherein the adhesive force is provided by a fluid, preferably a liquid, preferably silicone oil, between the actuator (210) and the membrane (120). Fluidic system (1000) according to claim 5, wherein the adhesive force is provided by an adhesion medium provided by rupturing capsules between the actuator (210) and the membrane (120). Fluidic system (1000) according to claim 5, wherein the adhesive force is provided by a gel, in particular by a hydrocolloid film, between the actuator (210) and the membrane (120). Fluidic system (1000) according to any one of claims 1 to 4, wherein the actuator (210) is connected to the membrane (120) by an adhesive bond.Fluidic system (1000) according to claim 9, wherein the bonding is provided by an adhesive film between the actuator (210) and the membrane (120), or wherein the bonding is provided by an adhesive membrane between the actuator (210) and the membrane (120). Fluidic system (1000) according to any one of claims 1 to 4, wherein the actuator (210) is connected to the membrane (120) by van der Waals forces and / or electrostatic forces, in particular wherein the actuator (210) and / or the membrane (120) comprises a plurality of adhesive elements (320). Fluidic system (1000) according to any one of claims 1 to 4, wherein the actuator (210) is connected to the membrane (120) by a vacuum. Fluidic system (1000) according to one of claims 1 to 4, wherein the actuator (210) is connected to the membrane (120) by a magnetic force, in particular wherein the membrane (120) is magnetic.A fluidic system (1000) according to any one of the preceding claims, wherein the membrane (120) is connected to a surface of the base body (110) via an attachment (121) and the attachment (121) completely surrounds a surface section of the membrane (120). A fluidic system (1000) according to any one of the preceding claims, wherein a sample can be introduced into the fluidic element (100) and wherein the fluidic element (100) a process unit (160) wherein the sample in the process unit (160) can be treated by a chemical, physical and / or biological process. Fluidic system (1000) according to any one of the preceding claims, wherein the membrane (120) is connected to the base body (110) such that a section of the membrane (120) that is not deformed by the actuator (110) contacts the base body (110). Method for operating a fluidic system (1000), in particular a fluidic system (1000) according to any one of the preceding claims, the method comprising the steps: Deformation of a membrane (120) connected to a base body (110) by an actuator (210) in the direction of the actuator (210) such that a cavity (131) is formed between the base body (110) and the membrane (120), wherein the actuator (210) comprises or consists of a magnetic shape memory alloy; Introducing a fluid from an outlet (152) of a first channel (151) of the base body (110) into the cavity (131); Moving the cavity (131) with the fluid through the actuator (210) towards an inlet (153) of a second channel (154); Introducing the fluid into the second channel (154) via the inlet (153).

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