Device for receiving sample vessels and kit comprising a device for receiving sample vessels

Abstract

An embodiment of a container 1 according to the invention for receiving sample vessels (cups) and / or pipette tips comprises a housing component 2 and a receiving component 3 with a first area 30 having a plurality (72) of first receiving positions 30.1, 30.2, 30.3,..., 30.72 (corresponding to the designations A1-F12) for a first type of sample vessels and / or pipette tips, and a second area 31 having a plurality (24) of second receiving positions 31.1, 31.2, 31.3,..., 31.24 (corresponding to the designations G1-H12) for a second type of sample vessels and / or pipette tips.

Description

TECHNICAL AREA

[0001] This application relates to a device for receiving sample containers and / or pipette tips, comprising a receiving component with multiple receiving positions. STATE OF THE ART

[0002] Manual and automatic pipetting devices or pipetting robots for handling pipette tips are used in a variety of analytical applications where liquids are handled, for example, transported, aspirated, or dispensed, such as in laboratories. These devices or robots use disposable pipette tips. Disposable pipette tips are generally conical in shape and may have specially shaped sections for gripping and sealing the pipette tip against a coupling device of the device or robot that engages inside the pipette tip. Pipetting devices or robots typically grip the top of the pipette tip. In many applications, the coupling device is inserted into the upper internal volume of the pipette tip.Pipetting robots exert a negative pressure to draw liquids into the pipette tip and create a positive pressure to dispense liquids from the pipette tip.

[0003] Furthermore, microtiter plates are used in the laboratory to examine the biological properties of samples, for example, through light absorption measurements or PCR (polymerase chain reaction) tests. Microtiter plates are used in various microbiological procedures. Typical applications include cell culture and the screening of bioreactions. Microtiter plates have a high number of wells, making them suitable for cultivation and for tests with large sample volumes and high throughput. Sample filling and dispensing from the wells are performed at high throughput using automated pipetting systems with the aforementioned pipette tips.

[0004] Microtiter plates are typically made of plastic, such as polypropylene, polystyrene, polyvinyl chloride, or polyamide. The sample wells can be arranged in a predetermined number in rows and columns within a tray. The number of wells on a microtiter plate tray is arbitrary and can range from a few single-digit numbers (e.g., 2x3) to several thousand (e.g., 48x72) wells. The wells can be made of the same material as the tray or of a different material.

[0005] Pipette tips and sample cups are typically manufactured from a malleable plastic, such as polypropylene (PP), polyethylene, polyphenylene sulfide (PPS), polycarbonate (PC), or similar materials, using an injection molding process. Plastics offer a good combination of properties, including chemical resistance, low surface adsorption, optional transparency, and cost-effective production. Pipette tips are also manufactured in various sizes to enable precise and reproducible handling of liquids across a wide volume range (from nanoliters to milliliters).

[0006] In many cases, pipette tips and sample wells are used in large quantities for the automated processing of a variety of samples and for adding different reagents to samples.

[0007] However, there are specific applications where pipette tips made of materials such as ceramic or metal are used, for example, in cases requiring high chemical resistance, corrosion resistance, or temperature resistance. Furthermore, ceramic pipette tips can be manufactured with smaller dimensions, particularly smaller outlet openings. However, ceramic or metallic pipette tips are considerably more complex in terms of manufacturing and material selection.

[0008] To facilitate the handling of these quantities, the pipette tips are often provided in a pipette tip tray, which has openings at the top where the pipette tips are arranged and held in an array. The tray can, in turn, be placed or mounted on a support. The tray and the support together form a pipette tip receptacle, which may optionally be equipped with a lid to cover the pipette tips.

[0009] Furthermore, receiving devices for pipette tips and / or sample vessels (microtiter plates) are designed in such a way that a large number of samples can be analyzed in parallel in analytical laboratories, with each receiving device being used for specific process steps. TASK OF INVENTION

[0010] Based on this, one object of the present invention is to provide containers for pipette tips and / or sample vessels (microtiter plates), trays for pipette tips and / or sample vessels (microtiter plates), and assemblies for holding pipette tips and / or sample vessels (microtiter plates) that enable specific processing of a sample in an automated analyzer. DESCRIPTION OF THE INVENTION

[0011] This problem is solved by a device for receiving pipette tips and / or sample vessels according to claim 1. Advantageous embodiments result from the features of the dependent claims.

[0012] An inventive device for receiving sample containers and / or pipette tips comprises: a receiving component with at least one first receiving position and at least one second receiving position for receiving at least one sample container and / or a pipette tip, wherein the at least two receiving positions have different configurations.

[0013] This means that the storage locations are suitable for different types and sizes of pipette tips and sample wells, and for the simultaneous storage of pipette tips and sample wells. The storage locations can be designed so that all pipette tips and sample wells required for a specific analysis program can be provided in a single container or tray. This enables individualized sample processing in an analyzer. The storage device is therefore a multifunctional microtiter plate, container, or tray for pipette tips and sample wells.

[0014] In particular, at least the first receiving position and at least the second receiving position are designed to receive different vessels and / or different types of pipette tips, and / or at least one receiving position is designed to receive a vessel and at least one receiving position is designed to receive a pipette tip.

[0015] Several analytical methods require liquid transfer between wells of different volumes. This is accommodated by a configuration according to the invention, in which a certain proportion x1 of the total receiving area is provided for receiving positions of type / size X1, a further proportion x2 for receiving positions of type / size X2, etc., with x1+x2+x3+....+xn= 100%, where n is the total number of receiving position types in a device.

[0016] By selecting a suitable arrangement of different types and sizes of sampling stations, for example, analytical procedures programmed in an analysis robot can be optimized in terms of time and reliability by shortening the distances involved in handling pipette tips and sample cups.

[0017] The receiving component can have a plate-like receiving surface, and the receiving locations can be designed as openings in the receiving component. The openings can be open at the bottom or closed at the bottom (blind openings). They can have different cross-sectional geometries.

[0018] Thus, the opening of the first recording position may have a different diameter than the opening of the second recording position. Although the term "diameter" normally refers to circular openings, in the context of this invention, the term should be understood as an average diameter when the opening has a different shape (e.g., square, elliptical, etc.).

[0019] The first and second receiving positions can each have a border region that limits the respective opening, with the border region of the first and the border region of the second receiving position being configured differently. For example, the opening can be limited by a sleeve with a specific axial length. The sleeve-like border region can be provided with different axial lengths and / or different geometries.

[0020] All receiving sites may have a support rim that limits a receiving opening for the support of a corresponding projection or ridge, which is designed on the outside of a cup or pipette tip to be compatible with a specific type / size of receiving site.

[0021] The receiving component can comprise an arrangement of at least one first area with first receiving positions and a second area with at least one second receiving position. Multiple areas can be provided for different types of sample wells or pipette tips, each with the same number of receiving positions.

[0022] Examples of such arrangements can be found in the following description of exemplary embodiments.

[0023] The areas can form self-contained modular units. This means that at least one of the areas, physically or virtually, constitutes or can be considered a module with a specific type of receiving station. Modular training can, in particular, mean that the modules form units with a specific type of receiving station, and / or are manufactured using different processes, and / or from different materials, and / or with different properties, and / or that they are manufactured as separate components and can be assembled and connected with other modules to form a container or tray.

[0024] The receiving component can essentially consist of areas arranged adjacent to each other, or the areas can be designed as individual modules.

[0025] The modularly designed areas can be joined together (e.g., plugged together) and / or attached to each other.

[0026] The modularly designed areas may include guide and / or fastening elements.

[0027] In particular, the device can be designed as a container comprising a housing component and the receiving component attached to it. The components can be designed as a single piece / integral or as multiple pieces. The container can optionally have a lid.

[0028] Alternatively, the device can be designed as a tray.

[0029] The object of the invention is also achieved by a combination of a tray as described above and a housing component (also referred to as a "rack" or "support"), wherein the tray is arranged on the housing component. The housing component can be a frame with a window arranged in the upper region of the frame for inserting the tray, and a base arranged in the lower region of the frame. In this case, the rack supports the tray.

[0030] With the aid of the devices or combinations according to the invention, a kit can be provided which, in addition to the device for holding sample containers and / or pipette tips as described above, also includes sample wells and / or pipette tips for use in a predefined analysis program. The wells may already contain reagents required by the analysis program. By means of a special or specially programmed automated analyzer into which the articles according to the invention are inserted, even persons without prior knowledge of sample handling for analysis can perform analytical procedures. BRIEF DESCRIPTION OF THE FIGURES

[0031] Further features and advantages of the invention will become clear from the following description with reference to the figures. These show: Fig. 1Ashows a perspective view of a first embodiment of a container according to the invention for holding sample vessels and / or pipette tips according to the present invention; Fig. 1B shows a top view of the first embodiment; Fig. 2A shows a perspective view of a second embodiment of a container according to the invention for holding sample vessels and / or pipette tips according to the present invention; Fig. 2B shows a top view of the second embodiment; Fig. 3A shows a perspective view of a third embodiment of a container according to the invention for holding sample vessels and / or pipette tips according to the present invention; Fig. 3B shows a top view of the third embodiment; Fig. 4A shows a perspective view of a fourth embodiment of a container according to the invention for holding sample vessels and / or pipette tips according to the present invention; Fig. 4B shows a top view of the fourth embodiment; Fig. 5A shows a perspective view of a fifth embodiment of a container according to the invention for holding sample vessels and / or pipette tips according to the present invention; Fig. 5B shows a top view of the fifth embodiment; Fig. 6A shows a perspective view of a sixth embodiment of a container according to the invention for holding sample vessels and / or pipette tips according to the present invention; Fig. 6B shows a top view of the sixth embodiment; Fig. 7A shows a perspective view of a seventh embodiment of a container according to the invention for receiving sample vessels and / or pipette tips according to the present invention; Fig. 7B shows a top view of the seventh embodiment; Fig. 8Ashows a perspective view of an eighth embodiment of a container according to the invention for receiving sample vessels and / or pipette tips according to the present invention; Fig. 8B shows a top view of the eighth embodiment; Fig. 9A shows a perspective view of a ninth embodiment of a container according to the invention for holding sample vessels and / or pipette tips according to the present invention; Fig. 9B shows a top view of the ninth embodiment; Fig. 10A shows a perspective view of a tenth embodiment of a container according to the invention for holding sample vessels and / or pipette tips according to the present invention; Fig. 10B shows a top view of the tenth embodiment; Fig. 11A shows a perspective view of an eleventh embodiment of a container according to the invention for receiving sample vessels and / or pipette tips according to the present invention; Fig. 11B shows a top view of the eleventh embodiment; Fig. 12A shows a perspective view of a twelfth embodiment of a container according to the invention for holding sample vessels and / or pipette tips according to the present invention; Fig. 12B shows a top view of the twelfth embodiment; Fig. 13A shows a perspective view of a thirteenth embodiment of a container according to the invention for receiving sample vessels and / or pipette tips according to the present invention; Fig. 13B shows a top view of the thirteenth embodiment; Fig. 13C shows a bottom view of the thirteenth embodiment; Fig. 14A shows a perspective view of a fourteenth embodiment of a container according to the invention for receiving sample vessels and / or pipette tips according to the present invention; Fig. 14B shows a top view of the fourteenth embodiment; Fig. 15Ashows a perspective view of a fifteenth embodiment of a container according to the invention for receiving sample vessels and / or pipette tips according to the present invention; Fig. 15B shows a top view of the fifteenth embodiment; Fig. 16A shows a perspective view of a first embodiment of a tray according to the invention; Fig. 16B shows a top view of the first embodiment of a tray; Fig. 17A shows a perspective view of a second embodiment of a tray according to the invention; Fig. 17B shows a top view of the second embodiment of a tray; Fig. 18A shows a perspective view of a third embodiment of a tray according to the invention; Fig. 18B shows a top view of the third embodiment of a tray; Fig. 19A shows a perspective view of a first embodiment of an assembly according to the invention; Fig. 19Bshows a top view of the first embodiment of an assembly; Fig. 20A shows a perspective view of a second embodiment of an assembly according to the invention; Fig. 20B shows a top view of the second embodiment of an assembly; Fig. 21A shows a perspective view of a third embodiment of an assembly according to the invention; Fig. 21B shows a top view of the third embodiment of an assembly; Fig. 22A shows a perspective view of a tray according to the invention with guide elements; Fig. 22B shows a top view of the tray with guide elements made of Figure 22A ; Fig. 22C shows a detail from Figure 22A . DESCRIPTION OF PREFERRED EXAMPLES OF THE INVENTION

[0032] The Figures 1A-22Cshow exemplary embodiments of the invention, which relates to combined elements such as microtiter plates with sample wells, pipette tip trays and containers with pipette tips and kits for multifunctional applications. Microtiter plates

[0033] Microtiter plates are typically made of plastic, e.g., polypropylene (PP), polyethylene (PE), polyethylene terephthalate (PET), polycarbonate (PC), polyvinyl chloride (PVC), polyethylene fluoroethylene (PEFE), polystyrene (PS), polysiloxanes, polyurethane, cellulose, polyamide (PA), polyphenylene sulfide (PPS), etc. The sample wells can be arranged in a predetermined number in a tray, in rows and columns. The number of wells on a microtiter plate tray is arbitrary and can range from a few single-digit numbers (e.g., 2x3) to several thousand (e.g., 48x72) well sites. The wells can be made of the same material as the tray or of a different material. Wells can be provided individually or multiple wells can be connected, e.g., as flat elements, strips, etc. Pipette tip images

[0034] A pipette tip holder or tray is an arrangement of components that provides pipette tips for use by a user. Pipette tip holders often include at least a support (rack), a lid, and a tray in which the pipette tips are mounted, with the pipette tips being arranged in an array that is essentially immobile.

[0035] The tray is positioned on the top of the carrier and has openings for receiving the pipette tips. The tray can be integrated directly into the carrier, e.g., molded onto it, or it can form a separate unit that is attached to the carrier, e.g., by a snap-fit ​​or locking connection, by gluing, welding, etc.

[0036] The pipette tips are removable and inserted into the tray openings. They typically rest on the edge of one of the tray openings. They may extend upwards beyond the tray's edge, while the lower portion of the pipette tips is usually below the tray's surface. The tray can have a suitable number of openings, e.g., 8 x n (n=1, 2,..., 432) openings.

[0037] Each component of the pipette tip holder can be made from a suitable material, e.g., from one or more plastic materials, e.g., polypropylene (PP), polyethylene (PE), polyethylene terephthalate (PET), polycarbonates (PC), polyvinyl chloride (PVC), polyethylene fluoroethylene (PEFE), polystyrene (PS), polysiloxanes, polyurethane, cellulose, polyamide (PA), polyphenylene sulfide (PPS), etc.

[0038] The components of the pipette tip holder or rest can be individually shaped and then assembled. Suitable manufacturing processes for the components include thermoforming, extrusion, or casting (plastic injection molding).

[0039] The components of the pipette tip holder are assembled or joined together. However, they can also be manufactured using a two-component injection molding process. The lid can be fitted precisely onto the holder, for example, by engaging a groove or recess in the holder. The lid can be loosely or movably connected to the holder, for example, via plug connections, or pivotally via a hinge. Pipette tips and sample cups

[0040] Pipette tips and sample cups are typically manufactured from malleable plastics, such as polypropylene (PP), polyethylene, polyphenylene sulfide (PPS), or similar materials, using an injection molding process. Plastics offer a good combination of properties, including chemical resistance, low surface adsorption, optional transparency, and cost-effective production. Pipette tips are also manufactured in various sizes to enable precise and reproducible handling of liquids across a wide volume range (from nanoliters to milliliters).

[0041] The pipette tips and sample wells inserted into the tray can be fixed horizontally and vertically, for example, by the shape of the tray's openings. The edges of the openings can be conical. Fixation can be achieved by positive locking, force locking, and / or friction locking. A material-bonded connection is also possible, particularly for the sample wells.

[0042] Pipette tips and sample cups with various geometries are known. The geometry of pipette tips and sample cups is adapted to enable their use with a coupling device of an analytical instrument or a pipetting device / automated system for aspirating and dispensing liquids. Pipette tips and sample cups are generally available in various sizes, e.g., 10 microliters, 50 microliters, 100 microliters, 250 microliters, 1000 microliters, 2500 microliters, etc.

[0043] The outer and inner contours of pipette tips are adapted for use with a specific pipetting device or automated pipetting system. Typically, the outer contour of pipette tips tapers from the upper (proximal) section to the lower (distal) section, which has a small opening.

[0044] The inner wall of the pipette tip defines a substantially tapered internal volume, which may also include sections with increases in the inner diameter or inwardly extending projections. The tapering can be continuous and / or stepped, steady and / or discontinuous, either overall or in sections. It must be ensured that a fluid drawn up has suitable flow properties and can be attached to a coupling device. In most embodiments, the inner wall of the pipette tip comprises at least two taper angles.

[0045] The outer and inner walls have a substantially tapered contour, for example, stepped or conical. The taper angle(s) are approximately between 0° and 30° relative to the central longitudinal axis, e.g., 0°, 5°, 10°, 15°, 20°, 25°, 30°. In some embodiments, the contour is stepped or cylindrical. Steps, stops, or grooves may also be provided.

[0046] A typical conventional pipette tip has a total length of approximately 2.5 cm to 10 cm. The distal dispensing orifice typically has an inner diameter of approximately 0.2 mm to 0.8 mm, e.g., 0.2 mm, 0.3 mm, 0.4 mm, 0.5 mm, 0.6 mm, 0.7 mm, 0.8 mm. The wall thickness in this area is approximately 0.1 mm to 0.5 mm, e.g., 0.1 mm, 0.2 mm, 0.3 mm, 0.4 mm, 0.5 mm.

[0047] In the proximal area, the inner diameter is approximately 2.5 mm to 10 mm, e.g. 2.5 mm, 5 mm, 7.5 mm, 10 mm, with a typical wall thickness in the proximal section between 0.5 mm and 1.5 mm, e.g. 0.5 mm, 0.75 mm, 1.0 mm, 1.25 mm, 1.5 mm.

[0048] The wall thickness can be constant along a section or vary continuously and / or in steps.

[0049] A proximal or distal section of a pipette tip may contain a filter, an insert, or other auxiliary material.

[0050] In one embodiment, (disposable) pipette tips comprise: a wall that delimits an interior space; a first, upper opening and a second, lower opening located at the upper and lower ends of the interior space, respectively; a first section adjoining the upper opening; a second section adjoining the first section; a third section adjoining the second section; a fourth section adjoining the third section; and a fifth section adjoining the fourth section and opening into the lower opening; a first transition region between the first section and the second section; a second transition region between the second section and the third section; a third transition region between the third section and the fourth section; wherein the sections and the transition regions have an internal contour or internal geometry, respectively.a design according to the following description of the invention.

[0051] The term "top" ("above") refers to the area of ​​the pipette tip wall or interior closer to the first, upper opening, into which a retaining / sealing pin of the pipetting system is designed to penetrate to hold and seal the pipette tip. The term "bottom" ("below") refers to the area of ​​the pipette tip wall or interior closer to the second, lower opening, through which the pipetted fluid is drawn in or dispensed during operation. The upper opening is generally larger than the lower opening.

[0052] The direction "from top to bottom" refers to the axial direction from the upper opening to the lower opening. "Axial" is a direction perpendicular to a plane defined by the upper and / or lower edge of the pipette tip. "Radial" means a direction parallel to the plane defined by the upper and / or lower edge of the pipette tip, i.e., perpendicular to "axial." A tapering or reduction in cross-section from top to bottom means that the cross-section at a position closer to the first opening is larger than the cross-section at a position closer to the second opening. A widening or enlargement of the cross-section occurs when the cross-section at a position closer to the first opening is smaller than the cross-section at a position closer to the second opening. This applies to both the sections of the pipette tip and the transition regions.

[0053] Sections of the pipette tip wall or interior have an axial and optionally also a radial extension. Transition areas of the pipette tip wall or interior can have an axial and / or a radial extension. However, they can also be formed as a continuous transition without axial / radial extension, e.g., as an edge.

[0054] An undercut occurs when there is a widening or increase in cross-sectional area (when viewing the interior through the upper opening towards the lower opening), as described above. An undercut can be a continuous transition with or without axial extension. A pipette tip according to the invention comprises: a wall that defines an interior space; a first, upper opening and a second, lower opening located at the upper end and lower end, respectively.are arranged at the lower end of the interior; a first section adjoining the upper opening; a second section adjoining the first section; a third section adjoining the second section; a fourth section adjoining the third section; and a fifth section adjoining the fourth section and opening into the lower opening; a first transition region between the first section and the second section; a second transition region between the second section and the third section; a third transition region between the third section and the fourth section); wherein the diameter of the upper opening is larger than the diameter of the lower opening; wherein the interior has at least sectionally cylindrical and / or downwardly tapering sections and / or transition regions.

[0055] Optionally, the interior can have at least one section and / or transition area that widens from top to bottom, forming an undercut.

[0056] In the Figures 1A and 1B A first embodiment of a container 1 according to the invention for receiving sample containers (cups) and / or pipette tips according to the present invention is shown.

[0057] Container 1 has a housing component 2 with four approximately vertically oriented wall elements 21, 22, 23, 24 and a base 20. Container 1 also has a receiving component 3 with a first area 30 having a plurality (72) of first receiving positions 30.1, 30.2, 30.3,..., 30.72 (corresponding to the designations A1-F12) for a first type of sample vessels and / or pipette tips, and a second area 31 having a plurality (24) of second receiving positions 31.1, 31.2, 31.3,..., 31.24 (corresponding to the designations G1-H12) for a second type of sample vessels and / or pipette tips.

[0058] For example, the first loading positions 30.1,..., 30.72 can be suitable for receiving wells corresponding to a microtiter plate. The wells can be individual and inserted at different first loading positions, or they can be segmented, e.g., as a strip with six wells that can be inserted into loading positions 30.1, 30.13, 30.25, 30.37, 30.49, 30.61, or the wells can be connected two-dimensionally as a planar element (array), e.g., as an element with 2x2=4 connected wells, which can be inserted, for example, into loading positions 30.11, 30.12, 30.23, and 30.24. The loading component 3 and the wells can be made of different materials. The bowls can be of the same or different shape and / or size, and / or made of the same or different materials.

[0059] For example, the second receptacles 31.1,..., 31.24 can be suitable for holding pipette tips. The pipette tips are usually individual and can be used in different second receptacles. The receptacle component 3 and the pipette tips can be made of different materials. The pipette tips can be of the same or different shape and / or size, and / or made of the same or different materials.

[0060] Container 1 can be equipped with wells and / or pipette tips required for a specific analysis program, such as one performed by an analytical robot. The wells are positioned at designated locations in the first compartment 30 and, if necessary, filled with reagents required by the analysis program. The pipette tips are positioned at designated locations in the second compartment. They are used to transport liquids through the analytical robot as part of the analysis program. This allows liquids to be transferred between the wells.

[0061] Container 1 is multifunctional, as it provides a microtiter plate in the first recording area 30 as well as a tray for pipette tips in the second area.

[0062] The container 1 according to the invention can itself form a tray that has or combines different receiving areas 30, 31. Alternatively, the container 1 can be modular, i.e., assembled from several parts. Thus, a first module can comprise the first receiving area 30, and a second module the second receiving area 31. The modules are joined together along a discontinuity plane 4. Different modules can therefore be combined, depending on the intended use.

[0063] Some of the compartments are designated for wells, others for pipette tips. Depending on the analysis program, the wells and pipette tips can have different geometries, volumes, materials, etc., and may be pre-filled with specific samples and reagents required for the analysis program. Such a kit, consisting of a container / tray / sample wells / pipette tips, can then be loaded with a sample to be analyzed (e.g., blood) and inserted into a small analyzer. An analysis program can then be started.

[0064] In the following exemplary embodiments, corresponding features are designated with the same reference numerals as in the Figures 1A and 1B .

[0065] In the Figures 2A and 2B A second embodiment of a container 1 according to the invention for receiving sample containers (cups) and / or pipette tips according to the present invention is shown.

[0066] Container 1 has a housing component 2 with four approximately vertically oriented wall elements 21, 22, 23, 24 and a base 20. Container 1 also has a receiving component 3 with a first area 30 having a plurality (48) of first receiving positions 30.1, 30.2, 30.3,..., 30.48 (corresponding to the designations A1-H6) for a first type of sample vessels and / or pipette tips, and a second area 31 having a plurality (48) of second receiving positions 31.1, 31.2, 31.3,..., 31.48 (corresponding to the designations G1-H12) for a second type of sample vessels and / or pipette tips.

[0067] For example, the first loading positions 30.1,..., 30.48 can be suitable for receiving wells corresponding to a microtiter plate. The wells can be of the same or different shape and / or size, and / or made of the same or different materials.

[0068] For example, the second storage locations 31.1,..., 31.48 can be suitable for holding pipette tips. The pipette tips can be of the same or different shape and / or size, and / or made of the same or different materials.

[0069] As described in the first embodiment, container 1 can be equipped with cups and / or pipette tips required in a specific analysis program, for example in an analysis robot.

[0070] In a kit including the container 1 according to the invention, trays for different tips (sizes / manufacturers) can also be combined. A first tray can be arranged in the first receiving area 30, and a second tray can be arranged either in the first or in the second receiving area 31. Electrically conductive and electrically non-conductive tips can be combined in one tray. Pipette tips of a first size can be arranged in one tray, pipette tips of a second size in another tray, etc., with the trays being arranged in a container 1.

[0071] Conventional microtiter plates, depending on the application, have a large number of wells, e.g., 96 wells, 384 wells, etc., of the same size (e.g., 2 ml, 0.2 ml,...). If different well sizes are required for a specific test, the different wells can be arranged in the different compartments 30 and 31. That is, compartments 30 and 31 are each adapted to hold wells (individually, as a strip, or as an array) of one type. This allows wells of different sizes (as well as pipette tips) to be combined in one container 1.

[0072] With a modular design, the modules can be connected to each other along a separation, interruption, or connection level 4 using areas 30 and 31, respectively. Possible connection methods include clipping, gluing, etc. The modules can be made of different materials. For example, one module can be transparent to allow visual inspection / analysis, while the other can be opaque.

[0073] In the second embodiment, for example, 48 slots for pipette tips and a further 48 slots for analysis vessels (microtiter plate) can be provided.

[0074] The kit can be processed with a programmed liquid handling system without the user needing expertise or experience in analytics.

[0075] The following embodiments are variants of the first and second embodiments, whereby the descriptions of the first and second embodiments are transferable to the following variants.

[0076] In the Figures 3A and 3B A third embodiment of a container 1 according to the invention for receiving sample containers (cups) and / or pipette tips is shown. In contrast to the previous embodiments, the container 1 has 88 receiving positions of a first type in the first area 30 and eight (8) receiving positions of a second type in the second area 31.

[0077] In the Figures 4A and 4BA fourth embodiment of a container 1 according to the invention for receiving sample containers (cups) and / or pipette tips is shown. In contrast to the previous embodiments, the container 1 has a second region 31, which is rectangular and occupies a section of one corner of the container 1 (with sections of the walls 22 and 23). Accordingly, two mutually perpendicular parting lines or seams 41, 42 are provided, arranged between the first region 30 and the second region 31.

[0078] In the second area 31, smaller receiving spaces 31.1,...,31.48 are arranged four times closer together than in the first area 30. The smaller receiving spaces are intended for bowls with a smaller volume.

[0079] In the Figures 5A and 5BFigure 1 shows a fifth embodiment of a container 1 according to the invention for receiving sample containers (cups) and / or pipette tips. In contrast to the previous embodiments, the container 1 has a second region 31, which is rectangular and occupies a space in the middle of the container 1, i.e., surrounded by the first region 30.

[0080] The part with the second area 31 can be designed as a module and inserted into a corresponding recess in the part with the first area 30. Accordingly, four parting planes or parting seams 41, 42, 43, 44, oriented perpendicular / parallel to each other, are provided between the second area 31 and the first area 30.

[0081] In the Figures 6A and 6BFigure 6 shows a sixth embodiment of a container 1 according to the invention for receiving sample vessels (cups) and / or pipette tips. In contrast to the fifth embodiment, a second region 31 is provided, which divides the first region 30 into an inner region 30i and an outer region 30a; that is, the second region 31 is arranged between the first regions 30i and 30a. Accordingly, an outer (rectangular in plan view) dividing seam 41 and an inner (rectangular in plan view) dividing seam 42 are provided between regions 30a and 31, and 30i, respectively.

[0082] In the Figures 7A and 7BFigure 7 shows a seventh embodiment of a container 1 according to the invention for receiving sample containers (cups) and / or pipette tips. This embodiment largely corresponds to the second embodiment, with the difference that only 12 (instead of 48) (4 times) larger receiving positions are provided in the second area.

[0083] Several analytical methods require fluid transfer between wells of different volumes. This is accommodated by a configuration corresponding to or similar to the seventh embodiment, in which a certain proportion x1 of the total area of ​​the receiving component 3 is provided for receiving positions of type / size X1, another proportion x2 for receiving positions of type / size X2, etc.

[0084] In the Figures 8A and 8BAn eighth embodiment of a container 1 according to the invention for receiving sample vessels (cups) and / or pipette tips is shown. This largely corresponds to the fourth embodiment, with the difference that only two (2) (instead of 48) (4 times) larger receiving spaces are provided in the second area 31.

[0085] In the Figures 9A and 9BFigure 9 shows a ninth embodiment of a container 1 according to the invention for receiving sample containers (cups) and / or pipette tips. This embodiment largely corresponds to the eighth embodiment, with the difference that here two (2) second areas 31a and 31b are provided, corresponding to the one second area 31 from the eighth embodiment. The areas each have two receiving positions 31.1, 31.2 and 31.3, 31.4, respectively, which are arranged in the corners of the container between the first wall 21 and the second wall 22 and between the second wall 22 and the third wall 23, respectively.

[0086] In the Figures 10A and 10BFigure 1 shows a tenth embodiment of a container 1 according to the invention for receiving sample vessels (cups) and / or pipette tips. This corresponds largely to the eighth embodiment, with the difference that a second area 31 with six (6) (4 times) larger receiving positions 31.1,..., 31.6 arranged in a row is provided. This row 31 interrupts the first area 30 and divides it into two first areas 30a and 30b.

[0087] In the Figures 11A and 11B Figure 1 shows an eleventh embodiment of a container 1 according to the invention for receiving sample containers (cups) and / or pipette tips. This embodiment is a combination of the fourth and tenth embodiments, wherein a second region 31 according to the fourth embodiment and a third region 32 corresponding to the second region 31 from the tenth embodiment are provided.

[0088] In the Figures 12A and 12B Figure 1 shows a twelfth embodiment of a container 1 according to the invention for receiving sample containers (cups) and / or pipette tips. This embodiment essentially corresponds to the eleventh embodiment. However, in contrast, the second region 31 and the third region 32 are each arranged as a transverse row. The second region 31 and the third region 32 are adjacent to each other. The third region 32 is also adjacent to the first region 30.

[0089] In the Figures 13A, 13B and 13CFigure 1 shows a thirteenth embodiment of a container 1 according to the invention for receiving sample vessels (cups) and / or pipette tips. This embodiment essentially corresponds to the first embodiment. However, in contrast, the second area 31 is arranged in an L-shape along two edges (walls 21 and 22). The second area 31 has receiving positions, one of which has 16 times the area of ​​a receiving position in the first area 30. The bottoms of areas 30 and 31 can be closed or open, depending on the application and purpose (see Figure 1). Figure 13C .

[0090] In the Figures 14A and 14BFigure 1 shows a fourteenth embodiment of a container 1 according to the invention for receiving sample vessels (cups) and / or pipette tips. This embodiment essentially corresponds to the eighth embodiment. However, in contrast, the first region 30 occupies a significantly smaller portion of the surface of the receiving component 3 than the second region, wherein the number of 16 receiving positions in the first region 30 is the same as the area of ​​a receiving position in the second region 31.

[0091] In the Figures 15A and 15BFigure 1 shows a fifteenth embodiment of a container 1 according to the invention for receiving sample containers (cups) and / or pipette tips. This embodiment corresponds essentially to previous embodiments. However, here the second area 31 consists of three sub-areas 31a, 31b, 31c, each with four (4) receiving positions. The sub-areas 31a, 31b, 31c of the second receiving area 31 each have four (4) receiving positions, each of which is the same size as a receiving position of the first area 30. The second receiving positions divide the first receiving area 30 into three and eighteen receiving positions, respectively, on either side of the diagonal.

[0092] In the Figures 16A and 16B A first embodiment of a tray 5 according to the invention for receiving sample containers (cups) and / or pipette tips according to the present invention is shown.

[0093] The tray 5 has a support component 6 with four side elements 61, 62, 63, 64 and a support surface 60. The support surface 60 can rest on a container component, so that the tray 5 together with a container component forms a modular container 1 according to the previous embodiments.

[0094] Furthermore, the tray 5 has a receiving component 3 with a first area 30 having a plurality (81) of first receiving places 30.1, 30.2, 30.3,..., 30.81 for a first type of sample vessels and / or pipette tips, and a second area 31 having a plurality (15) of second receiving places 31.1, 31.2, 31.3,..., 31.15 for a second type of sample vessels and / or pipette tips, as described in connection with the containers 1 according to the invention.

[0095] For example, the first loading positions 30.1,..., 30.81 can be suitable for receiving wells corresponding to a microtiter plate. The wells can be individual and used at different first loading positions, or they can be segmented, i.e., the wells can be connected as a strip or as a two-dimensional planar element, e.g., as an element with 2 x 2 = 4 wells. The loading component 3 and the wells can be made of different materials. The wells can be of the same or different shapes and / or sizes, and / or made of the same or different materials. The wells can also be permanently attached to the loading positions, or they can be formed as a single unit with the tray 5.

[0096] For example, the second holding positions 31.1,..., 31.15 can be suitable for holding pipette tips. The pipette tips are usually provided individually and can be used in different second holding positions. The holding component 3 and the pipette tips can be made of different materials. The pipette tips can be of the same or different shape and / or size, and / or made of the same or different materials.

[0097] Tray 5 can be equipped with wells and / or pipette tips required by a specific analysis program, for example, in an analytical robot. The wells are positioned at designated locations in the first area 30 and, if necessary, filled with reagents required by the analysis program. The pipette tips are positioned at designated locations in the second area. They are used to transport liquids through the analytical robot as part of the analysis program. This allows liquids to be transferred between the wells.

[0098] A kit including the tray according to the invention is multifunctional, as it combines a microtiter plate with sample wells in the first receiving area 30 with pipette tips in the second area 31.

[0099] Some of the storage positions are designated for wells, others for pipette tips. The wells can be integrated into tray 5, for example, in storage positions of the first section 30. Depending on the analysis program, the wells and pipette tips can have different geometries, volumes, materials, etc., and may be filled with specific reagents. Such a kit can then be loaded with a sample to be analyzed (e.g., blood) and inserted into a small analyzer. An analysis program is then started.

[0100] In the following exemplary embodiments, corresponding features are designated with the same reference numerals as in the Figures 16A and 16B .

[0101] In the Figures 17A and 17BFigure 1 shows a second embodiment of a tray 5 according to the invention for receiving sample containers (cups) and / or pipette tips. In contrast to the previous embodiment, the tray 5 has a receiving component 3 with a first area 30 having a plurality (66) of first receiving positions for a first type of sample container and / or pipette tips, a second area 31 having a plurality (15) of second receiving positions for a second type of sample container and / or pipette tips, and a third area 32 having a plurality (15) of third receiving positions for a third type of sample container and / or pipette tips.

[0102] The second area 31 and the third area 32 are each arranged as 3x5 arrays of recording locations in corners of the recording component 3.

[0103] In the Figures 18A and 18BA third embodiment of a tray 5 according to the invention for receiving sample containers (cups) and / or pipette tips is shown. In contrast to the first embodiment of a tray according to... Figures 16A, 16B Tray 5 comprises a receiving component 3 with a first area 30 containing a plurality (56) of first receiving positions for a first type of sample vials and / or pipette tips, and a second area 31 containing a plurality (40) of second receiving positions for a second type of sample vials and / or pipette tips. Areas 30 and 31 are enclosed on opposite sides of the receiving component 3. They are separated by a (virtual or real) separation plane 4.

[0104] In the Figures 19A and 19BA first embodiment of a combination according to the invention consisting of a housing and a tray 5, as previously described, for receiving sample containers (cups) and / or pipette tips according to the present invention is shown.

[0105] The housing, similar to the containers 1 described above, comprises a housing component 2 with four approximately vertically oriented wall elements 21, 22, 23, 24 and a base 20. The housing also has a central upper opening through which the tray 5 is placed. Alternatively, the housing can have a receiving component as described in connection with the containers 1 according to the invention, instead of the central opening.

[0106] Tray 5 is essentially the same as Tray 5 of the first embodiment ( Fig. 16A, 16B ) built.

[0107] In the Figures 20A and 20BA second embodiment of a combination according to the invention, consisting of a housing and a tray 5 as previously described, for receiving sample containers (wells) and / or pipette tips according to the present invention, is shown. In contrast to the previous embodiment, the tray 5 is, as in the Figures 17A, 17B presented and described, constructed.

[0108] In the Figures 21A and 21B A third embodiment of a combination according to the invention, consisting of a housing and a tray 5 as previously described, for receiving sample containers (wells) and / or pipette tips according to the present invention, is shown. In contrast to the previous embodiment, the tray 5 is, as in the Figures 18A, 18B presented and described, constructed.

[0109] In the Figures 22A and 22BFigure 1 shows an embodiment of a modular tray 5 according to the invention for receiving sample containers (wells) and / or pipette tips. In this embodiment, two areas 30, 31 are provided for receiving sample containers (wells) and / or pipette tips. However, the principle of modular subdivision and assembly is transferable to other arrangements of different areas 30, 31, 32 of trays 5, and to containers 1 according to the invention, as described above.

[0110] In the Figure 22A Modules 30 and 31 of tray 5 are shown separately, in the Figure 22B Tray 5 is assembled.

[0111] The interruption planes 4 between modules 30 and 31 can be provided with guide and / or fastening elements, enabling the modules to be joined or fixed together in a targeted manner. In this way, different variants can be connected to one another. For this purpose, elements for snapping, clipping, dovetail guides, guides, locking lugs, etc., can be provided in the area of ​​the interruption planes 4 (i.e., generally on the sides) of the individual modules 30 and 31. In this exemplary embodiment, a dovetail guide 400 was used, as shown in the enlarged detail view in Figure 22C emerges.

[0112] Each of the containers 1 and each of the trays 5 according to the invention can be designed as a single piece or, as described, modularly, i.e., assembled from several parts. For example, a first module can comprise the first receiving area 30, a second module the second receiving area 31, etc. The modules are joined together along one or more interruption levels 4. Different modules can thus be combined, depending on the intended use.

[0113] The materials of the individual modules 30, 31, 32 can be the same or different, depending on the intended use as a sample cup or pipette tip holder.

[0114] All receiving sites can have a support rim that defines a receiving opening, for the support of a corresponding projection or ridge, which is designed on the outside of a cup or pipette tip to be compatible with a specific type / size of receiving site. The opening can be limited by a sleeve of a specific axial length.

[0115] By selecting a suitable arrangement of different types and sizes of sampling stations, for example, analytical procedures programmed in an analysis robot can be optimized in terms of time and reliability by shortening the distances involved in handling pipette tips and sample cups.

Claims

1. Device (1, 5) for receiving sample containers and / or pipette tips, comprising: a receiving component (3) with at least one first receiving position (30) and at least one second receiving position (31) for receiving at least one sample container and / or pipette tip; wherein the at least two receiving positions (30, 31, 32) have different configurations.

2. Device (1, 5) for receiving sample vessels and / or pipette tips according to claim 1, wherein the at least first receiving position (30) and the at least second receiving position (31) are designed for receiving different vessels and / or different pipette tips, and / or at least one receiving position for receiving a vessel and at least one receiving position for receiving a pipette tip.

3. Device (1, 5) for receiving sample containers and / or pipette tips according to claim 1 or 2, wherein the receiving component (3) has a plate-like receiving plane, and the receiving places (30, 31, 32) are designed as openings in the receiving component (3).

4. Device (1, 5) for receiving sample containers and / or pipette tips according to claim 3, wherein the opening of the first receiving place (30) has a different diameter than the opening of the second receiving place (31).

5. Device (1, 5) for receiving sample containers and / or pipette tips according to claim 3, wherein the first receiving position (30) and the second receiving position (31) each have a rim area that limits the respective opening, wherein the rim area of ​​the first receiving position (30) and the rim area of ​​the second receiving position (31) are designed differently.

6. Device (1, 5) for receiving sample containers and / or pipette tips according to one of the preceding claims, wherein the receiving component (3) has an arrangement of at least one first area (30) with first receiving positions and one second area (31) with at least one second receiving position.

7. Device (1, 5) for receiving sample vessels and / or pipette tips according to claim 6, wherein the areas (30, 31) form self-contained modular areas.

8. Device (1, 5) for receiving sample containers and / or pipette tips according to claim 6 or 7, wherein the receiving component (3) essentially consists of adjacent areas (30, 31) or the areas (30, 31) are designed as individual modules.

9. Device (1, 5) for receiving sample containers and / or pipette tips according to claim 8, wherein the modularly designed areas (30, 31) can be joined together and / or attached to one another.

10. Device (1, 5) for receiving sample containers and / or pipette tips according to claim 9, wherein the modularly designed areas (30, 31) have guide and / or fastening elements (400).

11. Device according to one of the preceding claims, wherein the device is designed as a container (1) comprising a housing component (2) and the receiving component (3) arranged thereon.

12. Device according to one of the preceding claims, wherein the device is designed as a tray (5).

13. Combination of a device according to claim 12 and a housing component (2), wherein the tray (5) is arranged on the housing component (2).

14. Kit comprising a device (1, 5) according to one of the preceding claims and sample cups and / or pipette tips for use in a predetermined analysis program.

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