PARG inhibitory compounds

Abstract

The present invention relates to a compound of formula (I) or its enantiomer, diastereomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystal form, pharmaceutically acceptable salt or prodrug thereof.The present invention further relates to the compound of formula (I) of the present invention for use in therapy.The compound of the present invention is particularly useful as a PARC inhibitor and can be used in the method of treating proliferative disorders, preferably cancer. [Formula 1] JPEG2024537882000552.jpg25129

Description

[Technical Field]

[0001] The present invention provides compounds of formula (I):

[0002] [ka]

[0003] or its enantiomers, diastereomers, tautomers, pharmaceutically acceptable solvates, pharmaceutically acceptable crystalline forms, pharmaceutically acceptable salts, or prodrugs thereof. The present invention further relates to the compounds of formula (I) of the present invention for use in therapy. The compounds of the present invention are particularly useful as PARG inhibitors and can be used in methods for treating proliferative disorders, preferably cancer. [Background technology]

[0004] Cancer is a leading cause of death worldwide. Although progression-free survival and overall survival for cancer patients have improved over the past 20 years, millions of cancer patients still have few treatment options and poor survival outcomes (Jemal et al., J. Natl. Cancer Inst. 2017, 109, 1975).

[0005] DNA replication stress (DRS) is a hallmark of cancer cells and a major cause of genomic instability (a) Halazonetis et al., Science 2008, 319, 1352; b) Negrini et al., Nat. Rev. Mol. Cell Biol. 2010, 11, 220). Broadly defined, DRS refers to the deregulation of DNA replication and cell cycle progression. DRS can be induced by endogenous or exogenous causes, such as oncogene activation and chemotherapeutic agents, respectively (Zeman and Cimprich, Nat. Cell Biol. 2013, 16, 2). At the replication fork level, DRS leads to replication fork stalling, replisome disengagement, and eventual collapse. Several DNA repair proteins are involved in the stability, protection, and restart of replication forks under DRS conditions (a) Costantino et al., Science 2014, 343, 88; b) Scully et al., Curr. Opin. Genet. Dev. 2021 71, 154).

[0006] Poly(ADP) ribosylation (PARylation) is a transient and reversible post-translational modification that occurs at DNA damage sites and is catalyzed by the poly(ADP-ribose) polymerase (PARP) family of proteins (Cohen and Chang, Nat. Chem. Biol. 2018, 14, 236). PARylation of various DNA repair proteins leads to their activation. Degradation of poly(ADP) ribose chains is primarily mediated by poly(ADP-ribose) glycohydrolase (PARG) proteins. DNA damage-dependent PARylation / dePARylation is a rapid and dynamic process that must be well regulated, as an imbalance between the two processes can lead to DNA damage.

[0007] Human PARG encodes a 976-amino acid, 111-kDa protein. It contains an N-terminal regulatory domain, a catalytic domain, and an ADP-ribose-binding macrodomain. Five human PARG transcripts have been identified. Full-length PARG is predominantly nuclear; smaller isoforms are primarily localized in the cytoplasm. PARG functions primarily as an exohydrolase, hydrolyzing the α-O-glycosidic ribose-ribose bond in PAR, releasing primarily mono(ADP-ribose). PARG can also act as an endohydrolase. PARG preferentially degrades long, linear PAR chains, whereas its activity on small, branched PAR chains is significantly reduced (O'Sullivan et al., Nat. Commun. 2019, 10, 1182).

[0008] PARG is the major cellular PAR degrading enzyme, but it cannot act on terminal protein-ribose bonds. Additional hydrolases, such as terminal ADP-ribose protein glycohydrolase (TARG1) and ADP-ribosylhydrolase 3 (ARH3), are also known to catalyze PAR degradation. TARG1 and ARH3 complete the reversal of PARylation by removing the protein-bound mono(ADP-ribose) moiety (a) Fontana et al., Elife 2017, doi:10.7554 / eLife.28533; b) Rack et al., Genes Dev. 2020, 34, 263). TARG1 is located in the nucleus and cytoplasm. ARH3 is found primarily in the cytoplasm but can also be found in mitochondria and the nucleus (Rack et al., Genes Dev. 2020, 34, 263).

[0009] Genomic aberrations targeting tumor suppressor genes or oncogenes often render cancer cells dependent on specific DNA repair pathways. For example, PARP inhibitors are known to be particularly effective against tumors with mutations in the BRCA1 and BRCA2 genes (a) Bryant et al., Nature 2005, 434, 913; b) Farmer et al., Nature 2005, 434, 917). Targeting synthetic lethal interactions, such as those between PARP and BRCA, is an attractive novel therapeutic approach for cancer treatment.

[0010] PARG is involved in various DNA repair mechanisms, including DNA replication and single-strand break (SSB) repair and replication fork restart. PARG inhibitors demonstrated synthetic lethality in cells with high levels of DRS, which is caused by underexpression of genes involved in DNA replication and / or replication fork stability (Pillay et al., Cancer Cell. 2019, 35, 519). Furthermore, PARG inactivation, depletion, or inhibition sensitizes cells to DNA-damaging agents such as irradiation and alkylating agents (e.g., temozolomide and methyl methanesulfonate) (a) Fujihara et al., Curr. Cancer Drug Targets 2009, 9, 953; b) Gogola et al., Cancer Cell 2018, 33, 1078; c) Houl et al., Nat Commun. 2019, 10, 5654).

[0011] Considering the therapeutic potential of PARG inhibitors in cancer treatment, there is an increasing need for the development of highly potent and selective PARG inhibitors beyond those already described (a) James et al., ACS Chem. Biol. 2016, 11, 3179; b) Waszkowycz et al., J. Med. Chem. 2018, 61, 10767).

[0012] Certain compounds useful as PARG inhibitors are further disclosed in WO 2016 / 092326, WO 2016 / 097749 and WO 2021 / 055744.

[0013] US Patent Application Publication No. 2019 / 233411 discloses certain Gcn2 inhibitors and their uses.

[0014] WO 2009 / 050183 discloses certain imidazo[1,2-a]pyridine derivatives that are useful for treating diseases mediated by the ALK-5 and / or ALK-4 receptors. Summary of the Invention

[0015] The objective technical problem of the present invention was to provide compounds that are cell-permeable inhibitors of PARG. The technical problem of the present invention is solved by the embodiments described herein and characterized in the claims.

[0016] Thus, in a first embodiment, the present invention provides a compound of formula (I):

[0017] [ka]

[0018] or an enantiomer, diastereomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystalline form, pharmaceutically acceptable salt, or prodrug thereof. Throughout this specification, it is understood that the term "compound of formula (I)" preferably also encompasses the compounds of formulas (Ia) to (Ibo), unless otherwise indicated.

[0019] A further embodiment of the present invention relates to a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof, and a pharmaceutically acceptable carrier.

[0020] In a further embodiment, the present invention relates to a compound of formula (I) of the present invention or a pharmaceutically acceptable salt, hydrate or solvate thereof, or a pharmaceutical composition of the present invention, for use in therapy.

[0021] The compounds of formula (I) are useful for treating diseases or disorders in which PARG activity is implicated.

[0022] The compounds of formula (I) are useful in methods for treating proliferative disorders. In a preferred embodiment of the invention, the proliferative disorder is cancer, preferably human cancer.

[0023] definition The following definitions apply throughout the specification and claims, unless stated otherwise.

[0024] The term "hydrogen" is used herein to refer to protium, deuterium and / or tritium, preferably protium. Thus, the term "non-hydrogen atom" refers to any atom that is not hydrogen, i.e., not protium, deuterium or tritium.

[0025] The term "hydrocarbon group" refers to a group consisting of carbon and hydrogen atoms.

[0026] The term "alicyclic" is used in reference to a cyclic group to indicate that the corresponding cyclic group is non-aromatic.

[0027] As used herein, the term "alkyl" refers to a monovalent saturated acyclic (i.e., non-cyclic) hydrocarbon group which may be straight-chain or branched. Thus, an "alkyl" group does not contain any carbon-carbon double bonds or any carbon-carbon triple bonds. 1~5"Alkyl" means an alkyl group having 1 to 5 carbon atoms. Preferred exemplary alkyl groups are methyl, ethyl, propyl (e.g., n-propyl or isopropyl), or butyl (e.g., n-butyl, isobutyl, sec-butyl, or tert-butyl). Unless otherwise defined, the term "alkyl" preferably refers to a C 1~4 It refers to alkyl, more preferably methyl or ethyl, even more preferably methyl.

[0028] As used herein, the term "alkenyl" refers to a monovalent unsaturated acyclic hydrocarbon group, which may be straight or branched, and which contains one or more (e.g., one or two) carbon-carbon double bonds but no carbon-carbon triple bonds. 2~5 The term "alkenyl" refers to an alkenyl group having 2 to 5 carbon atoms. Preferred exemplary alkenyl groups are ethenyl, propenyl (e.g., prop-1-en-1-yl, prop-1-en-2-yl, or prop-2-en-1-yl), butenyl, butadienyl (e.g., buta-1,3-dien-1-yl or buta-1,3-dien-2-yl), pentenyl, or pentadienyl (e.g., isoprenyl). Unless otherwise defined, the term "alkenyl" preferably refers to an alkenyl group having 2 to 5 carbon atoms. 2~4 refers to alkenyl.

[0029] As used herein, the term "alkynyl" refers to a monovalent unsaturated acyclic hydrocarbon group that may be straight-chained or branched and that contains one or more (e.g., one or two) carbon-carbon triple bonds and optionally one or more (e.g., one or two) carbon-carbon double bonds. 2~5 The term "alkynyl" refers to an alkynyl group having 2 to 5 carbon atoms. Preferred exemplary alkynyl groups are ethynyl, propynyl (e.g., propargyl), or butynyl. Unless otherwise defined, the term "alkynyl" preferably refers to a C 2~4 refers to alkynyl.

[0030] As used herein, the term "alkylene" refers to an alkanediyl group, i.e., a divalent saturated acyclic hydrocarbon group which may be straight-chained or branched. 1~5 "Alkylene" refers to an alkylene group having 1 to 5 carbon atoms, and "C 0~3 The term "alkylene" refers to a covalent bond (corresponding to the option "C0 alkylene") or a C 1~3 indicates the presence of an alkylene. Preferred exemplary alkylene groups are methylene (-CH-), ethylene (e.g., -CH-CH- or -CH(-CH), propylene (e.g., -CH-CH-CH-, -CH(-CH-CH)-, -CH-CH(-CH)-, or -CH(-CH)-CH), or butylene (e.g., -CH-CH-CH-CH-). Unless otherwise defined, the term "alkylene" preferably refers to a C 1~4 Alkylene (especially linear C 1~4 alkylene), more preferably methylene or ethylene, and even more preferably methylene.

[0031] As used herein, the term "alkenylene" refers to an alkenediyl group, i.e., a divalent unsaturated acyclic hydrocarbon group, which may be straight-chained or branched, and which contains one or more (e.g., one or two) carbon-carbon double bonds but no carbon-carbon triple bonds. 2~5 "Alkenylene" refers to an alkenylene group having 2 to 5 carbon atoms. Unless otherwise defined, the term "alkenylene" preferably refers to an alkenylene group having 2 to 5 carbon atoms. 2~4 Alkenylene (especially linear C 2~4 (including alkenylene).

[0032] As used herein, the term "alkynylene" refers to an alkynediyl group, i.e., a divalent unsaturated acyclic hydrocarbon group that may be straight-chained or branched and that contains one or more (e.g., one or two) carbon-carbon triple bonds and optionally one or more (e.g., one or two) carbon-carbon double bonds. 2~5"Alkynylene" refers to an alkynylene group having 2 to 5 carbon atoms. Unless otherwise defined, the term "alkynylene" preferably refers to an alkynylene group having 2 to 5 carbon atoms. 2~4 Alkynylene (especially linear C 2~4 (including alkynylene).

[0033] As used herein, the term "carbocyclyl" refers to hydrocarbon ring groups, including monocyclic rings as well as bridged, spiro, and / or fused ring systems (which may, for example, be composed of two or three rings), and the ring groups may be saturated, partially unsaturated (i.e., unsaturated but not aromatic), or aromatic. Unless otherwise defined, "carbocyclyl" preferably refers to aryl, cycloalkyl, or cycloalkenyl.

[0034] As used herein, the term "heterocyclyl" refers to ring groups including monocyclic rings as well as bridged rings, spiro rings, and / or fused ring systems (which may, for example, be composed of two or three rings), which ring groups contain one or more (e.g., one, two, three, or four, etc.) ring heteroatoms independently selected from O, S, N, P, and Si, the remaining ring atoms are carbon atoms, and one or more S ring atoms (if present) and / or one or more N ring atoms (if present) and / or one or more P ring atoms (if present) may be optionally oxidized, one or more carbon ring atoms may be optionally oxidized (i.e., to form an oxo group), and further the ring group may be saturated, partially unsaturated (i.e., unsaturated but not aromatic), or aromatic. For example, each heteroatom-containing ring contained in a ring group may contain one or two O atoms and / or one or two S atoms (which may be optionally oxidized) and / or one, two, three, or four N atoms (which may be optionally oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may be optionally oxidized) in the corresponding heteroatom-containing ring. Unless otherwise defined, "heterocyclyl" preferably refers to heteroaryl, heterocycloalkyl, or heterocycloalkenyl.

[0035] Preferably, the term "heterocyclyl" refers to ring groups including monocyclic rings as well as bridged rings, spiro rings, and / or fused ring systems (which may, for example, be composed of two or three rings), which ring groups contain one or more (e.g., one, two, three, or four, etc.) ring heteroatoms independently selected from O, S, and N, the remaining ring atoms being carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) may be optionally oxidized, one or more carbon ring atoms may be optionally oxidized (i.e., to form an oxo group), and further wherein the ring group may be saturated, partially unsaturated (i.e., unsaturated but not aromatic), or aromatic. For example, each heteroatom-containing ring contained in a ring group may contain one or two O atoms and / or one or two S atoms (which may be optionally oxidized) and / or one, two, three, or four N atoms (which may be optionally oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may be optionally oxidized) in the corresponding heteroatom-containing ring. Unless otherwise defined, "heterocyclyl" preferably refers to heteroaryl, heterocycloalkyl, or heterocycloalkenyl.

[0036] As used herein, the term "aryl" refers to an aromatic hydrocarbon ring group, including monocyclic aromatic rings and bridged and / or fused ring systems containing at least one aromatic ring (e.g., a ring system composed of two or three fused rings, where at least one of the fused rings is aromatic; or a bridged ring system composed of two or three rings, where at least one of the bridged rings is aromatic). "Aryl" can refer to, for example, phenyl, naphthyl, diarylnyl (i.e., 1,2-dihydronaphthyl), tetralinyl (i.e., 1,2,3,4-tetrahydronaphthyl), indanyl, indenyl (e.g., 1H-indenyl), anthracenyl, phenanthrenyl, 9H-fluorenyl, or azulenyl. Unless otherwise defined, "aryl" preferably has 6 to 14 ring atoms, more preferably 6 to 10 ring atoms, and even more preferably refers to phenyl or naphthyl, and most preferably refers to phenyl.

[0037] As used herein, the term "arylene" refers to an aryl group, as defined hereinabove, but having two points of attachment, i.e., a divalent aromatic hydrocarbon ring group, and includes monocyclic aromatic rings as well as bridged and / or fused ring systems containing at least one aromatic ring (e.g., a ring system composed of two or three fused rings, where at least one of the fused rings is aromatic; or a bridged ring system composed of two or three rings, where at least one of the bridged rings is aromatic). "Arylene" can refer, for example, to phenylene (e.g., phen-1,2-diyl, phen-1,3-diyl, or phen-1,4-diyl), naphthylene (e.g., naphthalene-1,2-diyl, naphthalene-1,3-diyl, naphthalene-1,4-diyl, naphthalene-1,5-diyl, naphthalene-1,6-diyl, naphthalene-1,7-diyl, naphthalene-2,3-diyl, naphthalene-2,5-diyl, naphthalene-2,6-diyl, naphthalene-2,7-diyl, or naphthalene-2,8-diyl), 1,2-dihydronaphthylene, 1,2,3,4-tetrahydronaphthylene, indanylene, indenylene, anthracenylene, phenanthrenylene, 9H-fluorenylene, or azulenylene. Unless otherwise defined, "arylene" preferably has 6 to 14 ring atoms, more preferably 6 to 10 ring atoms, even more preferably refers to phenylene or naphthylene, and most preferably phenylene (especially phen-1,4-diyl).

[0038] As used herein, the term "heteroaryl" refers to aromatic ring groups, including monocyclic aromatic rings and bridged and / or fused ring systems containing at least one aromatic ring (e.g., a ring system composed of two or three fused rings, where at least one of the fused rings is aromatic; or a bridged ring system composed of two or three rings, where at least one of the bridged rings is aromatic), wherein the aromatic ring groups contain one or more (e.g., one, two, three, or four) ring heteroatoms independently selected from O, S, and N, the remaining ring atoms being carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized (i.e., to form an oxo group). For example, each heteroatom-containing ring within an aromatic ring group may contain one or two O atoms and / or one or two S atoms (which may be optionally oxidized) and / or one, two, three, or four N atoms (which may be optionally oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is one to four and that there is at least one carbon ring atom (which may be optionally oxidized) in the corresponding heteroatom-containing ring. "Heteroaryl" includes, for example, thienyl (i.e., thiophenyl), benzo[b]thienyl, naphtho[2,3-b]thienyl, thianthrenyl, furyl (i.e., furanyl), benzofuranyl, isobenzofuranyl, chromanyl, chromenyl (e.g., 2H-1-benzopyranyl or 4H-1-benzopyranyl), isochromenyl (e.g., 1H-2-benzopyranyl), chromonyl, xanthenyl, phenoxathiinyl, pyrrolyl (e.g., 1H-pyrrolyl), imidazolyl, pyrazolyl, pyridyl (i.e., pyridinyl; e.g., 2-pyridyl, 3-pyridyl, or 4-pyridyl), pyrazinyl, pyrimidinyl, pyridazinyl, indolyl (e.g., 3H-indolyl), isoindolyl, indazolyl, indolizinyl, purinyl, quinolyl, isoquinolyl, phthalazinyl, naphthyridinyl, quinoxalinyl, cinnolinyl, pteridinyl, carbazolyl, β-carbolinyl, phenanthridinyl, acridinyl, perimidinyl, phenanthrolinyl (e.g., [1,10]phenanthrolinyl, [1,7]phenanthrolinyl, or [4,7]phenanthrolinyl), phenazinyl, thiazolyl, isothiazolyl, phenothiazinyl, oxazolyl, isoxazolyl, oxadiazolyl (e.g., 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl (i.e., furazanyl), or 1,3,4-oxadiazolyl), thiadiazolyl (e.g., 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, or 1,3,4-thiadiazolyl), phenoxazinyl, pyrazolo[1,5-a]pyrimidinyl (e.g., pyrazolo[1,5-a]pyrimidin-3-yl), 1,2-benzisoxazol-3-yl, benzothiazolyl, benzothiadiazolyl, benzoxazolyl, benzisoxazolyl, benzimidazolyl, benzo[b]thiazolyl, phenyl (i.e., benzothienyl), triazolyl (e.g., 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, or 4H-1,2,4-triazolyl), benzotriazolyl, 1H-tetrazolyl, 2H-tetrazolyl, triazinyl (e.g., 1,2,3-triazinyl, 1,2,4-triazinyl, or 1,3,5-triazinyl), furo[2,3-c]pyridinyl, dihydrofuropyridinyl (e.g., 2,3-dihydrofuro[2,3-c]pyridinyl or 1,3-dihydrofuro[3,4-c]pyridinyl), imidazopyridinyl (e.g., imidazo[1,2-a]pyridinyl or imidazo[3,2-a]pyridinyl), quinazolinyl, thienopyridinyl, tetrahydrothienopyridinyl (e.g., 4,5,6,7-tetrahydrothieno[3,2-c]pyridinyl), dibenzofuranyl, 1,3-benzodioxolyl, benzodioxanyl (e.g., 1,3-benzodioxanyl or 1,4-benzodioxanyl) or coumarinyl. Unless otherwise defined, the term "heteroaryl" preferably refers to a 5- to 14-membered (more preferably 5- to 10-membered) monocyclic ring or fused ring system containing one or more (e.g., 1, 2, 3, or 4) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized; even more preferably, the term "heteroaryl" refers to a 5- or 6-membered monocyclic ring containing one or more (e.g., 1, 2, or 3) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized.

[0039] As used herein, the term "heteroarylene" refers to a heteroaryl group, as defined hereinabove, but having two points of attachment, i.e., a divalent aromatic ring group, including monocyclic aromatic rings and bridged and / or fused ring systems containing at least one aromatic ring (e.g., a ring system composed of two or three fused rings, at least one of which is aromatic; or a bridged ring system composed of two or three rings, at least one of which is aromatic), wherein the aromatic ring group contains one or more (e.g., one, two, three, or four) ring heteroatoms independently selected from O, S, and N, and the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized (i.e., to form an oxo group). For example, each heteroatom-containing ring contained in an aromatic ring group may contain one or two O atoms and / or one or two S atoms (optionally oxidized) and / or one, two, three, or four N atoms (optionally oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (optionally oxidized) in the corresponding heteroatom-containing ring. "Heteroarylene" includes, for example, thienylene (i.e., thiophenylene; e.g., thien-2,3-diyl, thien-2,4-diyl, or thien-2,5-diyl), benzo[b]thienylene, naphtho[2,3-b]thienylene, thianthrenylene, furylene (i.e., furanylene; e.g., furan-2,3-diyl, furan-2,4-diyl, or furan-2,5-diyl), benzofuranylene, isobenzofuranylene, chromanylene, chromenylene, isochromenylene, chromonylene, xanthenylene, phenoxathinylene, pyrrolylene, imidazolylene, pyrazolylene, pyridylene (i.e., pyridinylene), pyrazinylene, pyrimidinylene, pyridazinylene, indolylene, isoindolylene, indazolylene, indolizinylene, purinylene, quinolinylene, isoquinolinylene, phthalazinylene, naphthyridinylene, quinoxalinylene, cinnolinylene, pteridinylene, carbazolylene, β-carbolinylene thiazolinylene (e.g., thiazole-2,4-diyl, thiazole-2,5-diyl, or thiazole-4,5-diyl), isothiazolylene (e.g., isothiazole-3,4-diyl, isothiazole-3,5-diyl, or isothiazole-4,5-diyl), phenoxazinylene, oxazolylene (e.g., oxazole-2,4-diyl, oxazole-2,5-diyl, or oxazole-4,5-diyl), isoxazolylene (e.g., isoxazole-3,4-diyl, isoxazole-3,5-diyl, or isoxazole-4,5-diyl), oxadiazolylene (e.g., 1,2,4-oxadiazole-3,5-diyl, 1,2,5-oxadiazole-3,4-diyl, or 1,3,4-oxadiazole-2,5-diyl), thiadiazole (e.g., 1,2,4-thiadiazole-3,5-diyl, 1,2,5-thiadiazole-3,4-diyl, or 1,3,4-thiadiazole-2,5-diyl), phenoxazinylene, pyrazolo[1,5-a]pyridine, Imidazolylene, 1,2-benzisoxazolylene, benzothiazolylene, benzothiadiazolylene, benzoxazolylene, benzisoxazolylene, benzimidazolylene, benzo[b]thiophenylene (i.e., benzothienylene), triazolylene (e.g., 1H-1,2,3-triazolylene, 2H-1,2,3-triazolylene, 1H-1,2,4-triazolylene, or 4H-1,2,4-triazolylene), benzotriazolylene, 1H-tetrazolylene, 2H-tetrazolylene, triazinylene (1,2,3-triazinylene, 1,2,4-triazinylene, or 1,3,5-triazinylene), furo[2,3-c]pyridinylene, dihydrofuropyridinylene (e.g., 2,3-dihydrofuro[2,3-c]pyridinylene or 1,3-dihydrofuro[3,4-c]pyridinylene), imidazopyridinylene (e.g., imidazo[1,2-a]pyridinylene or imidazo[3,2-a]pyridinylene), quinazolinylene, thienopyridinylene, tetrahydrothienopyridinylene (e.g., 4,5,6,7-tetrahydrothieno[3,2-c]pyridinylene), dibenzofuranylene, 1,3-benzodioxolylene, benzodioxanylene (e.g., 1,3-benzodioxanylene or 1,4-benzodioxanylene), or coumarinylene. Unless otherwise defined, the term "heteroarylene" preferably refers to a divalent 5- to 14-membered (more preferably 5- to 10-membered) monocyclic ring or fused ring system containing one or more (e.g., 1, 2, 3, or 4) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized; even more preferably, the term "heteroarylene" refers to a divalent 5- or 6-membered monocyclic ring containing one or more (e.g., 1, 2, or 3) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized. A "heteroarylene," including any of the specific heteroarylene groups described herein, may be linked via two carbon ring atoms, particularly the two carbon ring atoms that are the greatest distance from each other (in terms of the number of ring atoms separating them by the shortest possible bond) within one single ring or within the entire ring system of the corresponding heteroarylene.

[0040] As used herein, the term "cycloalkyl" refers to a saturated hydrocarbon ring group, which includes monocyclic rings as well as bridged rings, spiro rings, and / or fused ring systems (e.g., may be composed of two or three rings; e.g., fused ring systems composed of two or three fused rings, etc.). "Cycloalkyl" can refer to, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, decalinyl (i.e., decahydronaphthyl), or adamantyl. Unless otherwise defined, "cycloalkyl" preferably refers to C 3~11 It refers to cycloalkyl, more preferably C 3~7 Particularly preferred "cycloalkyl" is a monocyclic saturated hydrocarbon ring having 3 to 7 ring members (e.g., cyclopropyl or cyclohexyl).

[0041] As used herein, the term "cycloalkylene" refers to a cycloalkyl group, as defined hereinabove, but having two points of attachment, i.e., a divalent saturated hydrocarbon ring group, and includes monocyclic rings as well as bridged rings, spiro rings, and / or fused ring systems (e.g., which may be composed of two or three rings; e.g., a fused ring system composed of two or three fused rings, etc.). "Cycloalkylene" can refer to, for example, cyclopropylene (e.g., cyclopropane-1,1-diyl or cyclopropane-1,2-diyl), cyclobutylene (e.g., cyclobutane-1,1-diyl, cyclobutane-1,2-diyl, or cyclobutane-1,3-diyl), cyclopentylene (e.g., cyclopentane-1,1-diyl, cyclopentane-1,2-diyl, or cyclopentane-1,3-diyl), cyclohexylene (e.g., cyclohexane-1,1-diyl, cyclohexane-1,2-diyl, cyclohexane-1,3-diyl, or cyclohexane-1,4-diyl), cycloheptylene, decalinylene (i.e., decahydronaphthylene), or adamantylene. Unless otherwise defined, "cycloalkylene" preferably refers to a C 3~11 It refers to cycloalkylene, more preferably C 3~7Particularly preferred "cycloalkylene" groups are divalent monocyclic saturated hydrocarbon rings having 3 to 7 ring members, such as cyclopropylene or cyclohexylene.

[0042] As used herein, the term "heterocycloalkyl" refers to saturated ring groups, including monocyclic rings as well as bridged rings, spiro rings, and / or fused ring systems (which may, for example, be composed of two or three rings; such as, for example, a fused ring system composed of two or three fused rings), which ring groups contain one or more (e.g., one, two, three, or four, etc.) ring heteroatoms independently selected from O, S, N, P, and Si, the remaining ring atoms being carbon atoms, with one or more S ring atoms (if present) and / or one or more N ring atoms (if present) and / or one or more P ring atoms (if present) optionally being oxidized, and further one or more carbon ring atoms optionally being oxidized (i.e., to form an oxo group). For example, each heteroatom-containing ring contained in a saturated ring group may contain one or two O atoms and / or one or two S atoms (which may be optionally oxidized) and / or one, two, three, or four N atoms (which may be optionally oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is one to four and there is at least one carbon ring atom (which may be optionally oxidized) in the corresponding heteroatom-containing ring. "Heterocycloalkyl" includes, for example, aziridinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, piperidinyl, piperazinyl, azepanyl, diazepanyl (e.g., 1,4-diazepanyl), oxazolidinyl, isoxazolidinyl, thiazolidinyl, isothiazolidinyl, morpholinyl (e.g., morpholin-4-yl), thiomorpholinyl (e.g., thiomorpholin-4-yl), oxazepanyl, oxazolidin ... It may refer to silanyl, oxetanyl, tetrahydrofuranyl, 1,3-dioxolanyl, tetrahydropyranyl, 1,4-dioxanyl, oxepanyl, thiiranyl, thietanyl, tetrahydrothiophenyl (i.e., thiolanyl), 1,3-dithiolanyl, thianyl, 1,1-dioxothianyl, thiepanyl, decahydroquinolinyl, decahydroisoquinolinyl, or 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl.Unless otherwise defined, the term "heterocycloalkyl" preferably refers to a 3- to 11-membered saturated ring group, which may be a monocyclic ring or a fused ring system (e.g., a fused ring system composed of two fused rings), wherein the ring group contains one or more (e.g., one, two, three, or four) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized; more preferably, the term "heterocycloalkyl" refers to a 5- to 7-membered saturated monocyclic ring group containing one or more (e.g., one, two, or three) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized.

[0043] Preferably, the term "heterocycloalkyl" refers to saturated ring groups, including monocyclic rings as well as bridged rings, spiro rings, and / or fused ring systems (which may, for example, be composed of two or three rings; such as, for example, a fused ring system composed of two or three fused rings), wherein the ring group contains one or more (e.g., one, two, three, or four, etc.) ring heteroatoms independently selected from O, S, and N, the remaining ring atoms being carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and further wherein one or more carbon ring atoms are optionally oxidized (i.e., to form an oxo group). For example, each heteroatom-containing ring contained in a saturated ring group may contain one or two O atoms and / or one or two S atoms (which may be optionally oxidized) and / or one, two, three, or four N atoms (which may be optionally oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is one to four and there is at least one carbon ring atom (which may be optionally oxidized) in the corresponding heteroatom-containing ring. "Heterocycloalkyl" includes, for example, aziridinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, piperidinyl, piperazinyl, azepanyl, diazepanyl (e.g., 1,4-diazepanyl), oxazolidinyl, isoxazolidinyl, thiazolidinyl, isothiazolidinyl, morpholinyl (e.g., morpholin-4-yl), thiomorpholinyl (e.g., thiomorpholin-4-yl), oxazepanyl, oxazolidin ... It may refer to silanyl, oxetanyl, tetrahydrofuranyl, 1,3-dioxolanyl, tetrahydropyranyl, 1,4-dioxanyl, oxepanyl, thiiranyl, thietanyl, tetrahydrothiophenyl (i.e., thiolanyl), 1,3-dithiolanyl, thianyl, 1,1-dioxothianyl, thiepanyl, decahydroquinolinyl, decahydroisoquinolinyl, or 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl.Unless otherwise defined, the term "heterocycloalkyl" preferably refers to a 3- to 11-membered saturated ring group, which may be a monocyclic ring or a fused ring system (e.g., a fused ring system composed of two fused rings), wherein the ring group contains one or more (e.g., one, two, three, or four) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized; more preferably, the term "heterocycloalkyl" refers to a 5- to 7-membered saturated monocyclic ring group containing one or more (e.g., one, two, or three) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized.

[0044] As used herein, the term "heterocycloalkylene" refers to a heterocycloalkyl group, as defined hereinabove, but having two points of attachment, i.e., a divalent saturated ring group, and includes monocyclic rings as well as bridged rings, spiro rings, and / or fused ring systems (which may, for example, be composed of two or three rings; such as, for example, a fused ring system composed of two or three fused rings), wherein the ring group contains one or more (e.g., one, two, three, or four, etc.) ring heteroatoms independently selected from O, S, N, P, and Si, the remaining ring atoms being carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) and / or one or more P ring atoms (if present) are optionally oxidized, and further wherein one or more carbon ring atoms are optionally oxidized (i.e., to form an oxo group). For example, each heteroatom-containing ring contained in a saturated ring group may contain one or two O atoms and / or one or two S atoms (which may be optionally oxidized) and / or one, two, three, or four N atoms (which may be optionally oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is one to four and there is at least one carbon ring atom (which may be optionally oxidized) in the corresponding heteroatom-containing ring. Examples of "heterocycloalkylene" include aziridinylene, azetidinylene, pyrrolidinylene, imidazolidinylene, pyrazolidinylene, piperidinylene, piperazinylene, azepanylene, diazepanylene (e.g., 1,4-diazepanylene), oxazolidinylene, isoxazolidinylene, thiazolidinylene, isothiazolidinylene, morpholinylene, thiomorpholinylene, oxazepanylene, oxiranylene, oxetanylene, tetrahydrofuran ... It may refer to hydrofuranylene, 1,3-dioxolanylene, tetrahydropyranylene, 1,4-dioxanylene, oxepanylene, thiiranylene, thietanylene, tetrahydrothiophenylene (i.e., thiolanylene), 1,3-dithiolanylene, thianylene, 1,1-dioxothianylene, thiepanylene, decahydroquinolinylene, decahydroisoquinolinylene, or 2-oxa-5-aza-bicyclo[2.2.1]hept-5-ylene.Unless otherwise defined, the term "heterocycloalkylene" preferably refers to a divalent 3- to 11-membered saturated ring radical, which may be a monocyclic ring or a fused ring system (e.g., a fused ring system composed of two fused rings), wherein the ring radical contains one or more (e.g., one, two, three, or four) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized; more preferably, the term "heterocycloalkylene" refers to a divalent 5- to 7-membered saturated monocyclic ring radical containing one or more (e.g., one, two, or three) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized.

[0045] Preferably, the term "heterocycloalkylene" refers to a heterocycloalkyl group, as defined hereinabove, but having two points of attachment, i.e., a divalent saturated ring group, including monocyclic rings as well as bridged rings, spiro rings, and / or fused ring systems (which may, for example, be composed of two or three rings; such as, for example, a fused ring system composed of two or three fused rings), wherein the ring group contains one or more (e.g., one, two, three, or four, etc.) ring heteroatoms independently selected from O, S, and N, the remaining ring atoms being carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and further wherein one or more carbon ring atoms are optionally oxidized (i.e., to form an oxo group). For example, each heteroatom-containing ring contained in a saturated ring group may contain one or two O atoms and / or one or two S atoms (which may be optionally oxidized) and / or one, two, three, or four N atoms (which may be optionally oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is one to four and there is at least one carbon ring atom (which may be optionally oxidized) in the corresponding heteroatom-containing ring. Examples of "heterocycloalkylene" include aziridinylene, azetidinylene, pyrrolidinylene, imidazolidinylene, pyrazolidinylene, piperidinylene, piperazinylene, azepanylene, diazepanylene (e.g., 1,4-diazepanylene), oxazolidinylene, isoxazolidinylene, thiazolidinylene, isothiazolidinylene, morpholinylene, thiomorpholinylene, oxazepanylene, oxiranylene, oxetanylene, tetrahydrofuran ... It may refer to hydrofuranylene, 1,3-dioxolanylene, tetrahydropyranylene, 1,4-dioxanylene, oxepanylene, thiiranylene, thietanylene, tetrahydrothiophenylene (i.e., thiolanylene), 1,3-dithiolanylene, thianylene, 1,1-dioxothianylene, thiepanylene, decahydroquinolinylene, decahydroisoquinolinylene, or 2-oxa-5-aza-bicyclo[2.2.1]hept-5-ylene.Unless otherwise defined, the term "heterocycloalkylene" preferably refers to a divalent 3- to 11-membered saturated ring radical, which may be a monocyclic ring or a fused ring system (e.g., a fused ring system composed of two fused rings), wherein the ring radical contains one or more (e.g., one, two, three, or four) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized; more preferably, the term "heterocycloalkylene" refers to a divalent 5- to 7-membered saturated monocyclic ring radical containing one or more (e.g., one, two, or three) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized.

[0046] As used herein, the term "N-heterocycloalkyl" refers to a heterocycloalkyl group, as defined above, which contains at least one nitrogen atom that serves as the point of attachment for the heterocycloalkyl.

[0047] As used herein, the term "cycloalkenyl" refers to an unsaturated alicyclic (non-aromatic) hydrocarbon ring group, which includes monocyclic rings as well as bridged rings, spiro rings, and / or fused ring systems (e.g., may be composed of two or three rings; e.g., a fused ring system composed of two or three fused rings, etc.), wherein the hydrocarbon ring group contains one or more (e.g., one or two) carbon-carbon double bonds and does not contain a carbon-carbon triple bond. "Cycloalkenyl" can refer to, for example, cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, cyclohexadienyl, cycloheptenyl, or cycloheptadienyl. Unless otherwise defined, "cycloalkenyl" preferably refers to C 3~11 It refers to cycloalkenyl, more preferably C 3~7Particularly preferred "cycloalkenyl" refers to a monocyclic unsaturated alicyclic hydrocarbon ring having 3 to 7 ring members, which contains one or more (e.g., one or two; preferably one) carbon-carbon double bonds.

[0048] As used herein, the term "cycloalkenylene" refers to a cycloalkenyl group, as defined hereinabove, but having two points of attachment, i.e., a divalent unsaturated alicyclic (non-aromatic) hydrocarbon ring group, including monocyclic rings as well as bridged rings, spiro rings and / or fused ring systems (e.g., which may be composed of two or three rings; such as a fused ring system composed of two or three fused rings), wherein the hydrocarbon ring group contains one or more (e.g., one or two) carbon-carbon double bonds and does not contain a carbon-carbon triple bond.

[0049] As used herein, the term "heterocycloalkenyl" refers to an unsaturated alicyclic (non-aromatic) ring group, which includes monocyclic rings as well as bridged rings, spiro rings, and / or fused ring systems (e.g., which may be composed of two or three rings; e.g., a fused ring system composed of two or three fused rings, etc.), wherein the ring group contains one or more (e.g., one, two, three, or four, etc.) ring heteroatoms independently selected from O, S, N, P, and Si, the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) and / or one or more P ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized (i.e., to form an oxo group), and wherein the ring group contains at least one double bond between adjacent ring atoms and does not contain any triple bonds between adjacent ring atoms. For example, each heteroatom-containing ring contained in an unsaturated alicyclic ring group may contain one or two O atoms and / or one or two S atoms (which may be optionally oxidized) and / or one, two, three, or four N atoms (which may be optionally oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is one to four and that there is at least one carbon ring atom (which may be optionally oxidized) in the corresponding heteroatom-containing ring. "Heterocycloalkenyl" includes, for example, imidazolinyl (e.g., 2-imidazolinyl (i.e., 4,5-dihydro-1H-imidazolyl), 3-imidazolinyl, or 4-imidazolinyl), tetrahydropyridinyl (e.g., 1,2,3,6-tetrahydropyridinyl), dihydropyridinyl (e.g., 1,2-dihydropyridinyl or 2,3-dihydropyridinyl), pyranyl (e.g., 2H-pyranyl or 4H- pyranyl), thiopyranyl (e.g., 2H-thiopyranyl or 4H-thiopyranyl), dihydropyranyl, dihydrofuranyl, dihydropyrazolyl, dihydropyrazinyl, dihydroisoindolyl, octahydroquinolinyl (e.g., 1,2,3,4,4a,5,6,7-octahydroquinolinyl), or octahydroisoquinolinyl (e.g., 1,2,3,4,5,6,7,8-octahydroisoquinolinyl).Unless otherwise defined, "heterocycloalkenyl" preferably refers to a 3- to 11-membered unsaturated alicyclic ring group, which may be a monocyclic ring or a fused ring system (e.g., a fused ring system composed of two fused rings), wherein the ring group contains one or more (e.g., 1, 2, 3, or 4) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, one or more carbon ring atoms are optionally oxidized, and the ring group has at least one carbon atom between adjacent ring atoms. and no triple bonds between adjacent ring atoms; more preferably, "heterocycloalkenyl" refers to a 5-7 membered monocyclic unsaturated non-aromatic ring group containing one or more (e.g., 1, 2, or 3) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized, and the ring group contains at least one double bond between adjacent ring atoms and no triple bonds between adjacent ring atoms.

[0050] Preferably, the term "heterocycloalkenyl" refers to an unsaturated alicyclic (non-aromatic) ring group, which includes monocyclic rings as well as bridged rings, spiro rings, and / or fused ring systems (e.g., which may be composed of two or three rings; e.g., a fused ring system composed of two or three fused rings, etc.), wherein the ring group contains one or more (e.g., one, two, three, or four, etc.) ring heteroatoms independently selected from O, S, and N, the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, wherein one or more carbon ring atoms are optionally oxidized (i.e., to form an oxo group), and further wherein the ring group contains at least one double bond between adjacent ring atoms and does not contain a triple bond between adjacent ring atoms. For example, each heteroatom-containing ring contained in an unsaturated alicyclic ring group may contain one or two O atoms and / or one or two S atoms (which may be optionally oxidized) and / or one, two, three, or four N atoms (which may be optionally oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is one to four and that there is at least one carbon ring atom (which may be optionally oxidized) in the corresponding heteroatom-containing ring. "Heterocycloalkenyl" includes, for example, imidazolinyl (e.g., 2-imidazolinyl (i.e., 4,5-dihydro-1H-imidazolinyl), 3-imidazolinyl, or 4-imidazolinyl), tetrahydropyridinyl (e.g., 1,2,3,6-tetrahydropyridinyl), dihydropyridinyl (e.g., 1,2-dihydropyridinyl or 2,3-dihydropyridinyl), pyranyl (e.g., 2H-pyranyl or 4H-pyranyl), -pyranyl), thiopyranyl (e.g., 2H-thiopyranyl or 4H-thiopyranyl), dihydropyranyl, dihydrofuranyl, dihydropyrazolyl, dihydropyrazinyl, dihydroisoindolyl, octahydroquinolinyl (e.g., 1,2,3,4,4a,5,6,7-octahydroquinolinyl), or octahydroisoquinolinyl (e.g., 1,2,3,4,5,6,7,8-octahydroisoquinolinyl).Unless otherwise defined, "heterocycloalkenyl" preferably refers to a 3- to 11-membered unsaturated alicyclic ring group, which may be a monocyclic ring or a fused ring system (e.g., a fused ring system composed of two fused rings), wherein the ring group contains one or more (e.g., 1, 2, 3, or 4) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, one or more carbon ring atoms are optionally oxidized, and the ring group has at least one carbon atom between adjacent ring atoms. and no triple bonds between adjacent ring atoms; more preferably, "heterocycloalkenyl" refers to a 5-7 membered monocyclic unsaturated non-aromatic ring group containing one or more (e.g., 1, 2, or 3) ring heteroatoms independently selected from O, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and one or more carbon ring atoms are optionally oxidized, and the ring group contains at least one double bond between adjacent ring atoms and no triple bonds between adjacent ring atoms.

[0051] As used herein, the term "heterocycloalkenylene" refers to a heterocycloalkenyl group, as defined hereinabove, but having two points of attachment, i.e., a divalent unsaturated alicyclic (non-aromatic) ring group, including monocyclic rings as well as bridged rings, spiro rings, and / or fused ring systems (which may, for example, be composed of two or three rings; such as a fused ring system composed of two or three fused rings), wherein the ring group contains one or more (e.g., one, two, three, or four, etc.) ring heteroatoms independently selected from O, S, N, P, and Si, the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) and / or one or more P ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized (i.e., to form an oxo group), and further wherein the ring group contains at least one double bond between adjacent ring atoms and does not contain a triple bond between adjacent ring atoms. For example, each heteroatom-containing ring contained in an unsaturated alicyclic ring group may contain one or two O atoms and / or one or two S atoms (which may be optionally oxidized) and / or one, two, three, or four N atoms (which may be optionally oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is one to four and that there is at least one carbon ring atom (which may be optionally oxidized) in the corresponding heteroatom-containing ring.

[0052] Preferably, the term "heterocycloalkenylene" refers to a heterocycloalkenyl group, as defined hereinabove, but having two points of attachment, i.e., a divalent unsaturated alicyclic (non-aromatic) ring group, including monocyclic rings as well as bridged rings, spiro rings, and / or fused ring systems (which may, for example, be composed of two or three rings; such as a fused ring system composed of two or three fused rings), wherein the ring group contains one or more (e.g., one, two, three, or four, etc.) ring heteroatoms independently selected from O, S, and N, the remaining ring atoms being carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, wherein one or more carbon ring atoms are optionally oxidized (i.e., to form an oxo group), and further wherein the ring group contains at least one double bond between adjacent ring atoms and does not contain a triple bond between adjacent ring atoms. For example, each heteroatom-containing ring contained in an unsaturated alicyclic ring group may contain one or two O atoms and / or one or two S atoms (which may be optionally oxidized) and / or one, two, three, or four N atoms (which may be optionally oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is one to four and that there is at least one carbon ring atom (which may be optionally oxidized) in the corresponding heteroatom-containing ring.

[0053] As used herein, the term "halogen" refers to fluoro (-F), chloro (-Cl), bromo (-Br), or iodo (-I). As will be understood by those of skill in the art, the terms "halogen" and "halo" can be used interchangeably.

[0054] As used herein, the term "haloalkyl" refers to an alkyl group substituted with one or more (preferably 1 to 6, more preferably 1 to 3) halogen atoms independently selected from fluoro, chloro, bromo, and iodo, preferably all fluoro atoms. It will be understood that the maximum number of halogen atoms is limited by the number of available bonding sites and, therefore, depends on the number of carbon atoms included in the alkyl portion of the haloalkyl group. "Haloalkyl" includes, for example, -CF3, -CHF2, -CH2F, -CF2-CH3, -CH2-CF3, -CH2-CHF 2、 It may refer to -CH2-CF2-CH3-CH2-CF2-CF3 or -CH(CF3)2. A particularly preferred "haloalkyl" group is -CF3.

[0055] The terms "bond" and "covalently bonded" are used interchangeably herein unless expressly indicated otherwise or contradicted by context.

[0056] As used herein, the terms "optional," "optionally," and "may" indicate that the indicated feature may be present, but may not be present. Whenever the terms "optional," "optionally," and "may" are used, the invention specifically relates to both possibilities, i.e., the presence of the corresponding feature, or, alternatively, the absence of the corresponding feature. For example, the phrase "X is optionally substituted by Y" (or "X may be substituted by Y") means that X is either substituted by Y or is unsubstituted. Similarly, when a component of a composition is indicated as "optional," the invention specifically relates to both possibilities, i.e., the presence of the corresponding component (contained in the composition) or the absence of the corresponding component in the composition.

[0057] Various groups are referred to herein as "optionally substituted." Generally, these groups can have one or more substituents, for example, 1, 2, 3, or 4 substituents. It will be understood that the maximum number of substituents is limited by the number of bonding sites available on the substituted moiety. Unless otherwise defined, "optionally substituted" groups referred to herein preferably have two or fewer substituents, and in particular may have only one substituent. Furthermore, unless otherwise defined, it is preferred that any substituents are absent, i.e., the corresponding group is unsubstituted.

[0058] Those skilled in the art will understand that the substituents contained in the compounds of the present invention can be attached to the remainder of the respective compound through several different positions of the corresponding specific substituent. Unless otherwise defined, preferred attachment positions for various specific substituents are as illustrated in the Examples.

[0059] As used herein, unless expressly indicated otherwise or contradicted by context, the terms "a," "an," and "the" are used interchangeably with "one or more" and "at least one." Thus, for example, a composition that includes "a" compound of Formula (I) can be interpreted as referring to a composition that includes "one or more" compounds of Formula (I).

[0060] Whenever numerical ranges are provided / disclosed herein, it is to be understood that all values ​​and subranges encompassed within each numerical range are meant to be encompassed within the scope of the invention. Accordingly, the present invention specifically and individually relates to each value that falls within the numerical ranges disclosed herein, and each subrange encompassed by the numerical ranges disclosed herein.

[0061] As used herein, the term "about" preferably refers to ±10% of the stated numerical value, more preferably ±5% of the stated numerical value, and particularly the exact numerical value stated. When the term "about" is used in connection with the endpoints of a range, it preferably refers to a range from the lower endpoint of the stated numerical value minus 10% to the upper endpoint of the stated numerical value plus 10%, more preferably a range from the lower endpoint minus 5% to the upper endpoint plus 5%, and even more preferably a range defined by the exact numerical values ​​of the lower and upper endpoints.

[0062] As used herein, the term "comprising" (or "comprise," "comprises," "contain," "contains," or "containing") means "containing, among other things," i.e., "containing, among other optional elements," unless expressly indicated otherwise or contradicted by context. In addition, the term also includes the narrower meanings of "consisting essentially of" and "consisting of." For example, the term "A comprising B and C" means "A contains, among other things, B and C," and although A may contain additional optional elements (e.g., "A containing B, C, and D" is also included), the term also includes the meanings "A consisting essentially of B and C" and "A consisting of B and C" (i.e., A does not contain any components other than B and C). DETAILED DESCRIPTION OF THE INVENTION

[0063] The present invention is described in detail below, with the understanding that the present invention relates specifically to each and every combination of the features and embodiments described herein, including any combination of the general and / or preferred features / embodiments.

[0064] In a first embodiment, the present invention provides a compound of formula (I):

[0065] [ka]

[0066] or its enantiomers, diastereomers, tautomers, pharmaceutically acceptable solvates, pharmaceutically acceptable crystalline forms, pharmaceutically acceptable salts, or prodrugs thereof.

[0067] R1 is hydrogen, chloro, fluoro, cyano, formyl, (C 1~2 ) alkyl, (C2) alkenyl, (C2) alkynyl, (C 1~2 ) haloalkyl, -(C 1~2 alkylene)-OH and -(C 1~2 alkylene)-O-(C 1~2 From the group consisting of chloro, fluoro, cyano, formyl, (C alkyl), preferably 1~2 ) alkyl, (C2) alkenyl, (C2) alkynyl, (C 1~2 ) haloalkyl, -(C 1~2 alkylene)-OH and -(C 1~2 alkylene)-O-(C 1~2 Preferably, R1 is selected from the group consisting of hydrogen, chloro, fluoro, cyano, formyl, (C 1~2 ) alkyl, (C2) alkenyl, (C2) alkynyl and (C 1~2 ) haloalkyl, preferably chloro, fluoro, cyano, formyl, (C 1~2 ) alkyl, (C2) alkenyl, (C2) alkynyl and (C 1~2 ) haloalkyl. More preferably, R1 is selected from the group consisting of cyano, (C 1~2 ) alkyl, and (C 1~2 ) haloalkyl. Preferably, the alkyl groups discussed herein are selected from the group consisting of (C 1~2 ) alkyl is methyl. Preferably, the (C 1~2) haloalkyl is fluoromethyl. Thus, preferably, R1 is selected from the group consisting of cyano, methyl, and fluoromethyl. More preferably, R1 is cyano. However, in another preferred embodiment, R1 is methyl, and in another particularly preferred embodiment where R1 is methyl, R1 is CD3. In yet another preferred embodiment, R1 is fluoromethyl.

[0068] R2 and R3 are independently selected from the group consisting of: 1~2 ) alkyl or (C 1~2 ) haloalkyl, preferably methyl, or R2 and R3 together with the carbon atom to which they are attached form cyclopropyl. Preferably, R2 and R3 together with the carbon atom to which they are attached form cyclopropyl.

[0069] W is -NHS(O) y -, -S(O) y and y is selected from NH—, —NHS(O)(NH)—, —NHS(O)(NCH3)—, —S(O)(NH)—NH—, —S(O)(NCH3)—NH—, and y is 1 or 2. Preferably, y is 2. Thus, in a preferred embodiment, W is selected from —NHS(O)2—, —S(O)2NH—, —NHS(O)(NH)—, and —S(O)(NH)—NH—. More preferably, W is selected from —NHS(O)2— and —S(O)2NH—, and even more preferably, W is —NHS(O)2—. Preferably, as understood herein, the left side of W, as defined herein, is attached to the carbon atom bearing R1, R2, and R3, and the right side of W, as defined herein, is attached to the ring system shown in formula (I). In one preferred embodiment, W is -NHS(O)2- or -NHS(O)(NCH3)-. In one preferred embodiment, W is -NHS(O)(NCH3)-.

[0070] X1 and X3 are independently N, CH, C(C 1~2X is selected from the group consisting of alkyl), CCl, and CF, and preferably is independently selected from the group consisting of N, CH, and CF. Preferably, X is CF or CH, and X is CH, more preferably X and X are each CH. However, in another preferred embodiment, X is CF and X is CH.

[0071] X2 is N or CY c2 -R c2 and preferably, X2 is CY c2 -R c2 is.

[0072] Y c2 is a covalent bond, C 1~5 Alkylene, C 2~5 Alkenylene, C 2~5 selected from alkynylene, cycloalkylene, cycloalkenylene, heterocycloalkylene, and heterocycloalkenylene, wherein alkylene, alkenylene, and alkynylene are each optionally selected from halogen, CN, OH, O(C 1~5 alkyl), -O(C 1~5 haloalkyl), C 1~5 Haloalkyl, SH, S(C 1~5 alkyl), -S(C 1~5 haloalkyl), NH2, NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), N(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), CONH2, CONH(C 1~5 alkyl), CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), NHCO-(C 1~5 alkyl), N(C 1~5 alkyl)-CO-(C 1~5 alkyl), NHCONH2, NHCONH-(C 1~5 alkyl), NHCON(C1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 alkyl)CONH2, N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), and preferably halogen, CN, OH, O(C 1~5 alkyl), SH, S(C 15 alkyl), NH2, NH(C 1~5 alkyl), and N(C 1~5 Alkyl)(C 1~5 alkyl), and further, one or more -CH2- units contained in the alkylene, alkenylene or alkynylene are each optionally selected from -O-, NH-, N(C 1~5 cycloalkylene, cycloalkenylene, heterocycloalkylene, and heterocycloalkenylene are each optionally substituted with a group independently selected from halogen, CN, OH, C 1~5 Alkyl, C 1~5 Haloalkyl, O(C 1~5 alkyl), -O(C 1~5 haloalkyl), SH, S(C 15 alkyl), -S(C 1~5 haloalkyl), NH2, NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), N(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), CONH2, CONH(C 1~5 alkyl), CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), NHCO-(C 1~5 alkyl), N(C 1~5 alkyl)-CO-(C 1~5alkyl), NHCONH2, NHCONH-(C 1~5 alkyl), NHCON(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 alkyl)CONH2, N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)SH, -(C 1~5 Alkylene)S(C 15 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)NH2, -(C 1~5 alkylene)NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)(N-heterocycloalkyl), -(C 1~5 alkylene)N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)CONH2, -(C 1~5 alkylene)CONH(C 1~5 alkyl), -(C 1~5 alkylene)CON(C 1~5Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)CO-(N-heterocycloalkyl), -(C 1~5 alkylene)NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)NHCONH2, -(C 1~5 alkylene)NHCONH-(C 1~5 alkyl), -(C 1~5 Alkylene)NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, CN, OH, C 1~5 Alkyl, O(C 1~5 alkyl), SH, S(C 15 alkyl), NH2, NH(C 1~5 alkyl), and N(C 1~5 Alkyl)(C 1~5 alkyl). Preferably, Y c2 is a covalent bond, C 1~5 Alkylene, C 2~5 Alkenylene, C 2~5 alkylene, cycloalkynylene, and heterocycloalkylene, wherein alkylene, alkenylene, and alkynylene are each optionally selected from halogen, CN, OH, O(C 1-5 alkyl), -O(C 1~5 haloalkyl), C 1~5 Haloalkyl, SH, S(C 15 alkyl), -S(C 1~5haloalkyl), NH2, NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), N(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), CONH2, CONH(C 1~5 alkyl), CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), NHCO-(C 1~5 alkyl), N(C 1~5 alkyl)-CO-(C 1~5 alkyl), NHCONH2, NHCONH-(C 1~5 alkyl), NHCON(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 alkyl)CONH2, N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), and preferably halogen, CN, OH, O(C 1~5 alkyl), SH, S(C 15 alkyl), NH2, NH(C 1~5 alkyl), and N(C 1~5 Alkyl)(C 1~5 alkyl), and further, one or more —CH units contained in the alkylene, alkenylene, or alkynylene are each optionally selected from —O—, NH—, N(C 1~5 and each of the cycloalkylene and heterocycloalkylene groups is optionally substituted by a group independently selected from halogen, CN, OH, C 1~5 Alkyl, C 1~5 Haloalkyl, O(C 1~5 alkyl), -O(C 1~5 haloalkyl), SH, S(C15 alkyl), -S(C 1~5 haloalkyl), NH2, NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), N(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), CONH2, CONH(C 1~5 alkyl), CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO(N-heterocycloalkyl), NHCO-(C 1~5 alkyl), N(C 1~5 alkyl)-CO-(C 1~5 alkyl), NHCONH2, NHCONH-(C 1~5 alkyl), NHCON(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 alkyl)CONH2, N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)OH, -(C 1~5 alkylene)O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)SH, -(C 1~5 Alkylene)S(C 15 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)NH2, -(C 1~5 alkylene)NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5alkylene)N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)(N-heterocycloalkyl), -(C 1~5 alkylene)N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)CONH2, -(C 1~5 alkylene)CONH(C 1~5 alkyl), -(C 1~5 alkylene)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)CO-(N-heterocycloalkyl), -(C 1~5 alkylene)NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)NHCONH2, -(C 1~5 alkylene)NHCONH-(C 1~5 alkyl), -(C 1~5 Alkylene)NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, CN, OH, C 1~5 Alkyl, O(C1~5 alkyl), SH, S(C 15 alkyl), NH2, NH(C 1~5 alkyl), and N(C 1~5 Alkyl)(C 1~5 alkyl). More preferably, Y C2 is a covalent bond, C 1~5 Alkylene, C 2~5 Alkenylene, and C 2~5 alkynylene, wherein alkylene, alkenylene, and alkynylene are each optionally selected from halogen, CN, OH, O(C 1~5 alkyl), -O(C 1~5 haloalkyl), C 1~5 Haloalkyl, SH, S(C 15 alkyl), -S(C 1~5 haloalkyl), NH2, NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), N(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), CONH2, CONH(C 1~5 alkyl), CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), NHCO-(C 1~5 alkyl), N(C 1~5 alkyl)-CO-(C 1~5 alkyl), NHCONH2, NHCONH(C 1~5 alkyl), NHCON(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 alkyl)CONH2, N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), and preferably halogen, CN, OH, O(C 1~5alkyl), SH, S(C 15 alkyl), NH2, NH(C 1~5 alkyl), and N(C 1~5 Alkyl)(C 1~5 alkyl), and further, one or more -CH2- units contained in the alkylene, alkenylene or alkynylene are each optionally selected from -O-, NH-, N(C 1~5 More preferably, Y is substituted by a group independently selected from the group consisting of -(alkyl), -CO-, -S-, -SO-, and -SO2-. c2 is a covalent bond, -(C 1~3 alkylene)-, -CO-(C 1~3 alkylene)-, (C 1~3 alkylene)-CO-, -CONH-(C 1~3 alkylene)-, -(C 1~3 alkylene)-CONH-, -NHCO-(C 1~3 alkylene)-, -(C 1~3 alkylene)-NHCO-, -NH-(C 1~3 alkylene)-, -(C 1~3 alkylene)-NH-, -N(C 1~5 alkyl)-, -O-(C 1~3 alkylene)-, -(C 1~3 alkylene)-O-, SO2-(C 1~3 alkylene)-, -(C 1~3 alkylene)SO2-, -CONH-, -NHCO-, -NH-, -O-, -CO- and SO2-. 1~3 Alkylene as used herein is preferably a -CH2- group.

[0073] R c2 is hydrogen, halo, -OH, -NH2, -SH, -CN, C 1~12 Alkyl, C 2~12 Alkenyl, C 2~12 is selected from alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl. Preferably, R c2 is hydrogen, halo, -OH, -NH2, -SH, -CN, C 1~12 Alkyl, C 2~12Alkenyl, C 2~12 More preferably, R is selected from alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl. c2 is selected from hydrogen, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl. Even more preferably, R c2 is selected from cycloalkyl, heterocycloalkyl, aryl, and heteroaryl. Even more preferably, R c2 is selected from heterocycloalkyl, aryl, and heteroaryl. The alkyl, alkenyl, or alkynyl is optionally selected from halogen, —CN, —OH, —O(C 1~5 alkyl), -O(C 1~5 haloalkyl), C 1~5 Haloalkyl, -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), and -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), preferably halogen, -CN, -OH, -O(C 1~5 alkyl)-, -O(C 1~5 haloalkyl), -C 1~5 Haloalkyl, -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 The cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl is optionally substituted with one or more groups independently selected from halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CO(C 1~5 haloalkyl), -CO-cycloalkyl, -COO(C 1~5 alkyl), -COO(C 1~5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 haloalkyl), -(C 1~5 alkylene)-CO-cycloalkyl, -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, CN, OH, C 1~5 Alkyl, C 1~5 Haloalkyl, O(C 1~5 alkyl), -O(C 1~5 haloalkyl), SH, S(C 1~5 alkyl), S(O)(C 1~5 alkyl), S(O)2(C 15 alkyl), S(O)(NH)(C 15 alkyl), S(O)(N(C 15 Alkyl))(C 15 alkyl), -N=S(O)(C 15 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), NH2 and NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), N(C 1~5 Alkyl)(C 1~5 alkyl)N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), COO(C 1~5 alkyl), CONH2, CONH(C 1~5 alkyl), CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), NHCO-(C 1~5 alkyl), N(C 1~5 alkyl)-CO-(C 1~5alkyl), NHCONH2, NHCONH-(C 1~5 alkyl), NHCON(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 alkyl)CONH2, N(C 1~5 alkyl)CONH-(C 1~5 alkyl), N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), NHCOO(C 1~5 alkyl), N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 15 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 15 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)OH, -(C 1~5 alkylene)O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)SH, -(C 1~5 Alkylene)S(C 15 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)S(O)(C 1~5 alkyl), -(C 1~5 alkylene)S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)S(O)(NH)(C 1~5 alkyl), -(C 1~5 Alkylene)S(O)(N(C 1~5 Alkyl))(C 1~5alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 15 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)NH2-(C 1~5 alkylene)NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)(N-heterocycloalkyl), -(C 1~5 alkylene)N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)CONH2, -(C 1~5 alkylene)CONH(C 1~5 alkyl), -(C 1~5 alkylene)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)CO-(N-heterocycloalkyl), -(C 1~5 alkylene)NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)NHCONH2, -(C 1~5 alkylene)NHCONH-(C 1~5 alkyl), -(C1~5 Alkylene)NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)N(C 1~5 alkyl)COO-(C 1~5 alkyl), more preferably halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 Alkire -NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 and substituted with one or more groups independently selected from alkyl.

[0074] Therefore, preferably, -Yc2-Rc2 is -OC 1~12 Alkyl, -NH-C 1~12 Alkyl, -N(C 1~5 Alkyl)-C 1~12 Alkyl, -OC 2~12 Alkenyl, -NH-C 2~12 Alkenyl, -N(C 1~5 Alkyl)-C 2~12 Alkenyl, -OC 2~12 Alkynyl, -NH-C 2~12Alkynyl, -N(C 1~5 Alkyl)-C 2~12 Alkynyl, (C 0~3 alkylene)-cycloalkyl, -CO-(C 0~3 alkylene)cycloalkyl, (C 0~3 alkylene)-CO-cycloalkyl, -CONH-(C 0~3 alkylene)cycloalkyl, -(C 0~3 alkylene)-CONH-cycloalkyl, -NHCO-(C 0~3 alkylene)cycloalkyl, (C 0~3 alkylene)-NHCO-cycloalkyl, -NH-(C 0~3 alkylene)cycloalkyl, -(C 0~3 alkylene)-NH-cycloalkyl, -O-(C 0~3 alkylene)cycloalkyl, -(C 0~3 alkylene)-O-cycloalkyl, -SO2-(C 0~3 alkylene)cycloalkyl, -(C 0~3 alkylene)-SO2-cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, -SO2-cycloalkyl, (C 0~3 alkylene)-cycloalkenyl, -CO-(C 0~3 alkylene)cycloalkenyl, (C 0~3 alkylene)-CO-cycloalkenyl, -CONH-(C 0~3 alkylene)cycloalkenyl, -(C 0~3 alkylene)-CONH-cycloalkenyl, -NHCO-(C 0~3 alkylene)cycloalkenyl, (C 0~3 alkylene)-NHCO-cycloalkenyl, -NH-(C 0~3 alkylene)cycloalkenyl, -(C 0~3 alkylene)-NH-cycloalkenyl, -O-(C 0~3 alkylene)cycloalkenyl, -(C 0~3 alkylene)-O-cycloalkenyl, -SO2-(C 0~3 alkylene)cycloalkenyl, -(C 0~3alkylene)-SO2-cycloalkenyl, -CONH-cycloalkenyl, -NHCO-cycloalkenyl, -NH-cycloalkenyl, -O-cycloalkenyl, -CO-cycloalkenyl, -SO2-cycloalkenyl, -(C 0~3 alkylene)-heterocycloalkyl, -CO-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-CO-heterocycloalkyl, -CONH-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-CONH-heterocycloalkyl, -NHCO-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-NHCO-heterocycloalkyl, -NH-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-NH-heterocycloalkyl, -O-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-O-heterocycloalkyl, -SO2-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C 0~3 alkylene)-heterocycloalkenyl, -CO-(C 0~3 alkylene)heterocycloalkenyl, -(C 0~3 alkylene)-CO-heterocycloalkenyl, -CONH-(C 0~3 -(C 0~3 alkylene)-CONH-heterocycloalkenyl, -NHCO-(C 0~3 -(C 0~3 alkylene)-NHCO-heterocycloalkenyl, -NH-(C 0~3 -(C 0~3 alkylene)-NH-heterocycloalkenyl, -O-(C 0~3alkylene)heterocycloalkenyl, -(C 0~3 alkylene)-O-heterocycloalkenyl, -SO2-(C 0~3 alkylene)heterocycloalkenyl, -(C 0~3 alkylene)-SO2-heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, -CO-heterocycloalkenyl, -SO2-heterocycloalkenyl, (C 0~3 alkylene)aryl, -CO-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-CO-aryl, -CONH-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-CONH-aryl, -NHCO-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-NHCO-aryl, -NH-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-NH-aryl, -O-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-O-aryl, -SO2-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO2-aryl, -(C 0~3 alkylene)heteroaryl, -CO-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-CO-heteroaryl, -CONH-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-CONH-heteroaryl, -NHCO-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-NHCO-heteroaryl, -NH-(C 0~3 alkylene)heteroaryl, (C 0~3 alkylene)-NH-heteroaryl, -O-(C0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-O-heteroaryl, -SO2-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, preferably -Y c2 -R c2 -OC 1~12 Alkyl, -NH-C 1~12 Alkyl, -N(C 1~5 Alkyl)-C 1~12 Alkyl, -OC 2~12 Alkenyl, -NH-C 2~12 Alkenyl, -N(C 1~5 Alkyl)-C 2~12 Alkenyl, -OC 2~12 Alkynyl, -NH-C 2~12 Alkynyl, -N(C 1~5 Alkyl)-C 2~12 Alkynyl, (C 0~3 alkylene)-cycloalkyl, -CO-(C 0~3 alkylene)cycloalkyl, (C 0~3 alkylene)-CO-cycloalkyl, -CONH-(C 0~3 alkylene)cycloalkyl, -(C 0~3 alkylene)-CONH-cycloalkyl, -NHCO-(C 0~3 alkylene)cycloalkyl, (C 0~3 alkylene)-NHCO-cycloalkyl, -NH-(C 0~3 alkylene)cycloalkyl, -(C 0~3 alkylene)-NH-cycloalkyl, -O-(C 0~3 alkylene)cycloalkyl, -(C 0~3 alkylene)-O-cycloalkyl, -SO2-(C 0~3 alkylene)cycloalkyl, -(C 0~3alkylene)-SO2-cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, -SO2-cycloalkyl, -(C 0~3 alkylene)-heterocycloalkyl, -CO-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-CO-heterocycloalkyl, -CONH-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-CONH-heterocycloalkyl, -NHCO-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -NH(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-NH-heterocycloalkyl, -O-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-O-cycloalkyl, -SO2-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, (C 0~3 alkylene)aryl, -CO-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-CO-aryl, -CONH-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-CONH-aryl, -NHCO-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-NHCO-aryl, -NH-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-NH-aryl, -O-(C 0~3 alkylene)aryl, -(C 0~3alkylene)-O-aryl, -SO2-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -COaryl, -SO2-aryl, -(C 0~3 alkylene)heteroaryl, -CO-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-CO-heteroaryl, -CONH-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-CONH-heteroaryl, -NHCO-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-NHCO-heteroaryl, -NH-(C 0~3 alkylene)heteroaryl, (C 0~3 alkylene)-NH-heteroaryl, -O-( C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-O-heteroaryl, -SO2-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, wherein alkyl, alkenyl or alkynyl is optionally selected from halogen, -CN, -OH, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), C 1~5 Haloalkyl, -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), and -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), preferably halogen, —CN, —OH, —O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -C 1~5 Haloalkyl, -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), wherein cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl are optionally selected from halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CO(C 1~5 haloalkyl), -CO-cycloalkyl, -COO(C 1~5 alkyl), -COO(C 1~5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl)-(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 haloalkyl), -(C 1~5 alkylene)-CO-cycloalkyl, -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -COO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl)-NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH- (C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), more preferably halogen, —CN, —OH, C1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2-NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl). More preferably, -Yc2-Rc2 is -(C 0~3 alkylene)-heterocycloalkyl, -CO-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-CO-heterocycloalkyl, -CONH-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-CONH-heterocycloalkyl, -NHCO-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-NHCO-heterocycloalkyl, -NH-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-NH-heterocycloalkyl, -O-(C 0~3 alkylene)heterocycloalkyl, (C 0~3 alkylene)-O-cycloalkyl, (C 0~3 alkylene)-O-heterocycloalkyl, -SO2-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C 0~3 alkylene)-heterocycloalkenyl, -CO-(C 0~3 alkylene)heterocycloalkenyl, -(C 0~3 alkylene)-CO-heterocycloalkenyl, -CONH-(C 0~3 alkylene)heterocycloalkenyl, -(C 0~3 alkylene)-CONH-heterocycloalkenyl, -NHCO-(C0~3 alkylene)heterocycloalkenyl, -(C 0~3 alkylene)-NHCO-heterocycloalkenyl, -NH-(C 0~3 alkylene)heterocycloalkenyl, -(C 0~3 alkylene)-NH-heterocycloalkenyl, -O-(C 0~3 alkylene)heterocycloalkenyl, (C 0~3 alkylene)-O-heterocycloalkenyl, -SO2-(C 0~3 alkylene)heterocycloalkenyl, -(C 0~3 alkylene)-SO2-heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, CO-heterocycloalkenyl, -SO2-heterocycloalkenyl, -(C 0~3 alkylene)aryl, -CO-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-CO-aryl, -CONH-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-CONH-aryl, -NHCO-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-NHCO-aryl, -NH-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-NH-aryl, -O-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-O-aryl, -SO2-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO2-aryl, -(C 0~3 alkylene)heteroaryl, -CO-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-CO-heteroaryl, -CONH-(C 0~3 alkylene)heteroaryl, -(C 0~3alkylene)-CONH-heteroaryl, -NHCO-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-NHCO-heteroaryl, -NH-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-NH-heteroaryl, -O-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-O-heteroaryl, -SO2-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, preferably -Y c2 -R c2 is -(C 0~3 alkylene)-heterocycloalkyl, -CO-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-CO-heterocycloalkyl, -CONH-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-CONH-heterocycloalkyl, -NHCO-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-NHCO-heterocycloalkyl, -NH-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-NH-heterocycloalkyl, -O-(C 0~3 alkylene)heterocycloalkyl, (C 0~3 alkylene)-O-cycloalkyl, -SO2-(C 0~3 alkylene)heterocycloalkyl, -(C 0~3 alkylene)-SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C 0~3alkylene)aryl, -CO-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-CO-aryl, -CONH-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-CONH-aryl, -NHCO(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-NHCO-aryl, -NH-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-NH-aryl, -O-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-O-aryl, -SO2-(C 0~3 alkylene)aryl, -(C 0~3 alkylene)-SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO2-aryl, -(C 0~3 alkylene)heteroaryl, -CO-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-CO-heteroaryl, -CONH-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-CONH-heteroaryl, -NHCO-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-NHCO-heteroaryl, -NH-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-NH-heteroaryl, -O-(C 0~3 alkylene)heteroaryl, -(C 0~3 alkylene)-O-heteroaryl, -SO2-(C 0~3 alkylene)heteroaryl, -(C 0~3and -SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl, and -SO2-heteroaryl, wherein heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl is optionally selected from halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CO(C 1~5 haloalkyl), -CO-cycloalkyl, -COO(C 1~5 alkyl), -COO(C 1~5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene) -P(O)(C1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2-(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 haloalkyl), -(C 1~5 alkylene)-CO-cycloalkyl, -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), CO(C 1~5 alkyl), -COO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2-(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(W-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl).

[0075] More preferably, -Yc2-Rc2 is -(C 0~3 alkylene)-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C 0~3 alkylene)-heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, -CO-heterocycloalkenyl, -SO2-heterocycloalkenyl, -(C 0~3 alkylene)aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO2-aryl, -(C 0~3 alkylene)heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, preferably -Yc2-Rc2 is selected from -(C 0~3 alkylene)-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C 0~3 alkylene)aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO2-aryl, -(C 0~3 heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally selected from halogen, —CN, —OH, C 1~5Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CO(C 1~5 haloalkyl), -CO-cycloalkyl, -COO(C 1~5 alkyl), -COO(C 1~5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), (C 1-5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 haloalkyl), -(C 1~5 alkylene)-CO-cycloalkyl, -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -COO(C 1~5alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl) , -(C 1~5alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 Haloalkyl(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl)-N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2-(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl)NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -NH2, -NH(C 1~5 alkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl).

[0076] Even more preferably, -Yc2-Rc2 is -(C 0~3 alkylene)-heterocycloalkyl, -(C 0~3alkylene)-heterocycloalkenyl, -(C 0~3 alkylene)aryl, and -(C 0~3 alkylene)heteroaryl, and preferably -Yc2-Rc2 is selected from -(C 0~3 alkylene)-heterocycloalkyl, -(C 0~3 alkylene)aryl, and -(C 0~3 and heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl are optionally selected from halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CO(C 1~5 haloalkyl), -CO-cycloalkyl, -COO(C 1~5 alkyl), -COO(C 1~5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO(C 1~5 alkyl), -N(C 1~5alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 haloalkyl), -(C 1~5 alkylene)-CO-cycloalkyl, -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -COO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 a alkylene)-N(C1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2-(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl)-(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl)-NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -(C 1~5 alkylene)-OH, -(C1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -NH2-NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl).

[0077] Even more preferably, -Yc2-Rc2 is selected from heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl, more preferably heterocycloalkyl, aryl, and heteroaryl, more preferably heterocycloalkyl and heteroaryl, and even more preferably heterocycloalkyl, wherein the heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl is optionally selected from halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CO(C 1~5 haloalkyl), -CO-cycloalkyl, -COO(C 1~5 alkyl), -COO(C1~5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 haloalkyl), -(C 1~5 alkylene)-CO-cycloalkyl, -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -COO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2-(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 haloalkyl), -S(C 1~5 alkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl).

[0078] In one embodiment, -Yc2-Rc2 is heterocycloalkenyl, wherein the heterocycloalkenyl is optionally selected from the group consisting of halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CO(C 1~5 haloalkyl), -CO-cycloalkyl, -COO(C 1~5alkyl), -COO(C 1~5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 haloalkyl), -(C 1~5 alkylene)-CO-cycloalkyl, -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -COO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 Al alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl)-N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -NH2-NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl).

[0079] Preferably, -Yc2-Rc2 is aryl, and -Yc2-Rc2 is optionally halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CO(C 1~5 haloalkyl), -CO-cycloalkyl, -COO(C 1~5alkyl), -COO(C 1~5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 haloalkyl), -(C 1~5 alkylene)-CO-cycloalkyl, -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2-(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -COO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocyclo alkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl)-NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl).

[0080] Preferably, -Y c2 -R c2 is heteroaryl, and -Y c2 -R c2 imidazolyl, pyridazinyl, thiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, or indazolyl, and heteroaryl is optionally selected from the group consisting of halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2-NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl).

[0081] Preferably, -Y c2 -R c2 When -Y is heterocycloalkyl, c2 -R c2 is morpholinyl, 1,1-dioxothiomorpholinyl, azetinyl, pyrrolidinyl, piperidinyl, 6-oxo-1,6-dihydropyridinyl, or piperazinyl, and heterocycloalkyl is optionally selected from halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CO(C 1~5 haloalkyl), -CO-cycloalkyl, -COO(C 1~5 alkyl), -COO(C 1~5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 haloalkyl), -(C 1~5 alkylene)-CO-cycloalkyl, -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl)-N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -COO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2-(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 a (C)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl)-N(C 1~5 Alkyl)(C1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 More preferably, -Yc2-Rc2 is piperazinyl, optionally selected from halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CO(C 1~5 haloalkyl), -CO-cycloalkyl, -COO(C 1~5 alkyl), -COO(C 1~5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 haloalkyl), -(C 1~5 alkylene)-CO-cycloalkyl, -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2-(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -COO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), -NHCOO(C 1~5 alkyl), -N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)COO-(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C1~5 haloalkyl), -NH 2. -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 Even more preferably, -Y C2 -R C2 is -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5and preferably N-piperazinyl, optionally substituted (preferably N-substituted) with alkyl. Most preferably, -Y C2 -R C2 is -CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably piperazinyl (preferably N-piperazinyl) substituted (preferably N-substituted, preferably at an N atom different from the N atom attached to the ring system shown in formula (I)) by —CON(CH3)2.

[0082] Preferably, -Y C2 -R C2 When -Y is heterocycloalkenyl, C2 -R C2 is oxacyclohexenyl or azacyclohexenyl, and heterocycloalkenyl is optionally selected from halogen, CN, OH, C 1~5 Alkyl, C 1~5 Haloalkyl, O(C 1~5 alkyl), -O(C 1~5 haloalkyl), SH, S(C 15 alkyl), S(O)(C 15 alkyl), S(O)2(C 15 alkyl), S(O)(NH)(C 15 alkyl), S(O)(N(C 15 Alkyl))(C 15 alkyl), -N=S(O)(C 15 Alkyl)(C 15 alkyl), -S(C 1~5 haloalkyl), NH2, NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), N(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CO(C 1~5 haloalkyl), -CO-cycloalkyl, COO(C 1~5 alkyl), -COO(C 1~5haloalkyl), -COO-cycloalkyl, CONH2, CONH(C 1~5 alkyl), CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl)NHCO-(C 1~5 alkyl), N(C 1~5 alkyl)-CO-(C 1~5 alkyl), NHCONH2, NHCONH-(C 1~5 alkyl), NHCON(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 alkyl)CONH2, N(C 1~5 alkyl)CONH-(C 1~5 alkyl), N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), NHCOO(C 1~5 alkyl), N( C1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 15 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 15 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)OH, -(C 1~5 alkylene)O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)SH, -(C 1~5 Alkylene)S(C 15 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)S(O)(C15 alkyl), -(C 1~5 alkylene)S(O)2(C 15 alkyl), -(C 1~5 alkylene)S(O)(NH)(C 15 alkyl), -(C 1~5 Alkylene)S(O)(N(C 15 Alkyl))(C 15 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 15 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 15 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)NH2, -(C 1~5 alkylene)NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)(N-heterocycloalkyl), -(C 1~5 alkylene)N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 haloalkyl), -(C 1~5 alkylene)-CO-cycloalkyl, -(C 1~5 alkylene)CONH2, -(C 1~5 alkylene)CONH(C 1~5 alkyl), -(C 1~5 alkylene)CON(C 1~5 Alkyl)(C1~5 alkyl), -(C 1~5 alkylene)CO-(N-heterocycloalkyl), -(C 1~5 alkylene)NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)NHCONH2, -(C 1~5 alkylene)NHCONH(C 1~5 alkyl), -(C 1~5 Alkylene)NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2-(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, CN, OH, C 1~5 Alkyl, C 1~5 Haloalkyl, O(C 1~5 alkyl), -O(C 1~5 haloalkyl), SH, S(C 15 alkyl), S(O)(C 15 alkyl), S(O)2(C 15alkyl), S(O)(NH)(C 15 alkyl), S(O)(N(C 15 Alkyl))(C 15 alkyl), -N=S(O)(C 15 Alkyl)(C 15 alkyl), -S(C 1~5 haloalkyl), NH2, NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), N(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), COO(C 1~5 alkyl), CONH2, CONH(C 1~5 alkyl), CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), NHCO-(C 1~5 alkyl), N(C 1~5 alkyl)-CO-(C 1~5 alkyl), NHCONH2, NHCONH-(C 1~5 alkyl), NHCON(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 alkyl)CONH2, N(C 1~5 alkyl)CONH-(C 1~5 alkyl), N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), NHCOO(C 1~5 alkyl), N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 15 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 15alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)OH, -(C 1~5 alkylene)O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)SH, -(C 1~5 Alkylene)S(C 15 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)S(O)(C 15 alkyl), -(C 1~5 alkylene)S(O)2(C 15 alkyl), -(C 1~5 alkylene)S(O)(NH)(C 15 alkyl), -(C 1~5 Alkylene)S(O)(N(C 15 Alkyl))(C 15 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 15 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 15 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)NH2, -(C 1~5 alkylene)NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C1~5 alkylene)(N-heterocycloalkyl), -(C 1~5 alkylene)N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)CONH2, -(C 1~5 alkylene)CONH(C 1~5 alkyl), -(C 1~5 alkylene)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)CO-(N-heterocycloalkyl), -(C 1~5 alkylene)NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)NHCO NH2-(C 1~5 alkylene)NHCONH-(C 1~5 alkyl), -(C 1~5 Alkylene)NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2-(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)NHCOO(C 1~5alkyl), and -(C 1~5 alkylene)N(C 1~5 alkyl)COO-(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl),-(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5alkyl), -O(C 1~5 haloalkyl), -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2-NH(C1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl). More preferably, -Y C2 -R C2 is azacyclohexenyl, optionally containing halogen, CN, OH, C 1~5 Alkyl, C 1~5 Haloalkyl, O(C 1~5 alkyl), -O(C 1~5 haloalkyl), SH, S(C 15 alkyl), S(O)(C 15 alkyl), S(O)2(C 15 alkyl), S(O)(NH)(C 15 alkyl), S(O)(N(C 15 Alkyl))(C 15 alkyl), -N=S(O)(C 15 Alkyl)(C 15 alkyl), -S(C 1~5 haloalkyl), NH2, NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), N(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CO(C 1~5 haloalkyl), -CO-cycloalkyl, COO(C 1~5 alkyl), -COO(C 1~5 haloalkyl), -COO-cycloalkyl, CONH2, CONH(C 1~5 alkyl), CON(C 1~5 Alkyl)(C 1~5alkyl), -CO-(N-heterocycloalkyl), NHCO-(C 1~5 alkyl), N(C 1~5 alkyl)-CO-(C 1~5 alkyl), NHCONH2, NHCONH-(C 1~5 alkyl), NHCON(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 alkyl)CONH2, N(C 1~5 alkyl)CONH-(C 1~5 alkyl), N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), NHCOO(C 1~5 alkyl), N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 15 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 15 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)OH, -(C 1~5 alkylene)O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)SH, -(C 1~5 Alkylene)S(C 15 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)S(O)(C 15 alkyl), -(C 1~5 alkylene)S(O)2(C 15 alkyl), -(C 1~5alkylene)S(O)(NH)(C 15 alkyl), -(C 1~5 Alkylene)S(O)(N(C 15 Alkyl))(C 15 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 15 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 15 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)NH2, -(C 1~5 alkylene)NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)(N-heterocycloalkyl), -(C 1~5 alkylene)N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 haloalkyl), -(C 1~5 alkylene)-CO-cycloalkyl, -(C 1~5 alkylene)CONH2, -(C 1~5 alkylene)CONH(C 1~5 alkyl), -(C 1~5 alkylene)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)CO-(N-heterocycloalkyl), -(C 1~5alkylene)NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)NHCONH2, -(C 1~5 alkylene)NHCONH-(C 1~5 alkyl), -(C 1~5 Alkylene)NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)N(C 1~5 alkyl)COO-(C 1~5 alkyl), preferably halogen, CN, OH, C 1~5 Alkyl, C 1~5 Haloalkyl, O(C 1~5 alkyl), -O(C 1~5 haloalkyl), SH, S(C 15 alkyl), S(O)(C 15 alkyl), S(O)2(C 15 alkyl), S(O)(NH)(C 15 alkyl), S(O)(N(C 15 Alkyl))(C 15alkyl), -N=S(O)(C 15 Alkyl)(C 15 alkyl), -S(C 1~5 haloalkyl), NH2, NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), N(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), COO(C 1~5 alkyl), CONH2, CONH(C 1~5 alkyl), CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), NHCO-(C 1~5 alkyl), N(C 1~5 alkyl)-CO-(C 1~5 alkyl), NHCONH2, NHCONH-(C 1~5 alkyl), NHCON(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 alkyl)CONH2, N(C 1~5 alkyl)CONH-(C 1~5 alkyl), N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -OCONH2, -OCONH-(C 1~5 alkyl), -OCON(C 1~5 Alkyl)(C 1~5 alkyl), NHCOO(C 1~5 alkyl), N(C 1~5 alkyl)COO-(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 15 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 15 alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C1~5 alkylene)OH, -(C 1~5 alkylene)O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)SH, -(C 1~5 Alkylene)S(C 15 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)S(O)(C 15 alkyl), -(C 1~5 alkylene)S(O)2(C 15 alkyl), -(C 1~5 alkylene)S(O)(NH)(C 15 alkyl), -(C 1~5 Alkylene)S(O)(N(C 15 Alkyl))(C 15 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 15 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 15 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)NH2, -(C 1~5 alkylene)NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)(N-heterocycloalkyl), -(C 1~5 alkylene)N(C 1~5 haloalkyl)(C 1~5alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)CONH2, -(C 1~5 alkylene)CONH(C 1~5 alkyl), -(C 1~5 alkylene)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)CO-(N-heterocycloalkyl), -(C 1~5 alkylene)NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)NHCONH2, -(C 1~5 alkylene)NHCONH-(C 1~5 alkyl), -(C 1~5 Alkylene)NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -(C 1~5 alkylene)N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-OCONH2, -(C 1~5 alkylene)-OCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-OCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)NHCOO(C 1~5 alkyl), and -(C 1~5 alkylene)N(C 1~5 alkyl)COO-(C 1~5 alkyl), more preferably halogen, —CN, —OH, C1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(O)(C 1~5 alkyl), -S(O)2(C 1~5 alkyl), -S(O)(NH)(C 1~5 alkyl), -S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -N=S(O)(C 1~5 Alkyl)(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl)-NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C1 ~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -P(O)(O(C 1~5 alkyl))(O(C 1~5alkyl)), -P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-S(O)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)2(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(NH)(C 1~5 alkyl), -(C 1~5 alkylene)-S(O)(N(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 alkyl))(O(C 1~5 alkyl), -(C 1~5 alkylene)-P(O)(O(C 1~5 Alkyl))(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C1~5 haloalkyl)(C 1~5 alkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 Even more preferably, -Y C2 -R C2 is -CON(C 1~5 Alkyl)(C 1~5 Preferably, the azacyclohexenyl referred to herein is 1,2,3,6-tetrahydropyridinyl.

[0083] In another preferred embodiment, -Y C2 -R C2 When -Y is heterocycloalkyl, C2 -R C2 are 2-oxaspiro[3.5]non-6-en-7-yl, 2-oxaspiro[3.5]non-7-yl, 2-oxa-8-azaspiro[4.5]dec-8-yl, 9-oxa-3-azaspiro[5.5]undec-3-yl, 2-oxa-6-azaspiro[3.4]oct-6-yl, 1-oxa-7-azaspiro[3.5]non-7-yl, 1-oxa-8-azaspiro[4.5]dec-8-yl, 6-oxa-2-azaspiro[3.3]hept-2-yl, 2,8-diazo-2-azamis ... azaspiro[4.5]dec-8-yl, 7-oxa-3-azabicyclo[3.3.0]oct-3-yl, 8-oxa-3-azabicyclo[4.3.0]non-3-yl, 2-oxa-6-azaspiro[3.5]non-6-yl, 7-oxo-3,6,8-triazabicyclo[4.3.0]non-3-yl, 3-pyrrolino[3,4-c]pyrazol-2-yl, 3,6-diazabicyclo[3.1.1]hept-3-yl, or 2,7-diazaspiro[3.5]non-7-yl.

[0084] In one particular embodiment, -Y C2 -R C2 teeth:

[0085] [ka]

[0086] is selected from.

[0087] In one particular embodiment, -Y C2 -R C2 teeth:

[0088] [ka]

[0089] is selected from.

[0090] In one particular embodiment, -Y C2 -R C2 teeth:

[0091] [ka]

[0092] is selected from.

[0093] X4 is N or CR C4 is.

[0094] R C4 is hydrogen, halo, C 1~6 Alkyl, C 2~6 Alkynyl, -O(C 1~6 alkyl), -S(C 1~6 alkyl), -NH(C 1~6 alkyl), -N(C 1~6 Alkyl)(C 1~6 alkyl), -CO(C 1~6 alkyl), C 1~6 Haloalkyl, -O(C 1~6 haloalkyl), -S(C 1~6 haloalkyl), -NH(C 1~6 haloalkyl), -N(C 1~6haloalkyl)2, -CO(C 1~6 haloalkyl), -(C 0~3 alkylene)cycloalkyl, -O-(C 0~3 alkylene)-cycloalkyl, -CO-(C 0~3 alkylene)-cycloalkyl, -(C 0~3 alkylene)cycloalkenyl, -O-(C 0~3 alkylene)-cycloalkenyl, -CO-(C 0~3 alkylene)-cycloalkenyl, -(C 0~3 alkylene)-heterocycloalkyl, -O-(C 0~3 alkylene)-heterocycloalkyl, -CO-(C 0~3 alkylene)-heterocycloalkyl, -(C 0~3 alkylene)-heterocycloalkenyl, -O-(C 0~3 alkylene)-heterocycloalkenyl, -CO-(C 0~3 alkylene)-heterocycloalkenyl, -(C 0~3 alkylene)-aryl, -O-(C 0~3 alkylene)-aryl, -CO-(C 0~3 alkylene)-aryl, -(C 0~3 alkylene)-heteroaryl, -O-(C 0~3 alkylene)-heteroaryl and -CO-(C 0~3 alkylene)-heteroaryl, preferably hydrogen, halo, C 1~6 Alkyl, C 2~6 Alkynyl, -O(C 1~6 alkyl), -S(C 1~6 alkyl), -NH(C 1~6 alkyl), -N(C 1~6 Alkyl)(C 1~6 alkyl), -CO(C 1~6 alkyl), C 1~6 Haloalkyl, -O(C 1~6 haloalkyl), -S(C 1~6 haloalkyl), -NH(C 1~6 haloalkyl), -N(C 1~6 haloalkyl)2, -CO(C 1~6 haloalkyl), -(C 0~3alkylene)cycloalkyl, -O-(C 0~3 alkylene)-cycloalkyl, -CO-(C 0~3 alkylene)-cycloalkyl, -(C 0~3 alkylene)-heterocycloalkyl, -O-(C 0~3 alkylene)-heterocycloalkyl, -CO-(C 0~3 alkylene)-heterocycloalkyl, -(C 0~3 alkylene)-aryl, -O-(C 0~3 alkylene)-aryl, -CO-(C 0~3 alkylene)-aryl, -(C 0~3 alkylene)-heteroaryl, -O-(C 0~3 alkylene)-heteroaryl and -CO-(C 0~3 The alkyl or alkynyl is optionally selected from halogen, —CN, —OH, —O(C 1~5 alkyl), -O(C 1~5 haloalkyl), C 1~5 Haloalkyl, -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, —O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably alkyl is optionally selected from halogen, —CN, —OH, —O(C 1~5 alkyl), -O(C 1~5 haloalkyl), C 1~5 Haloalkyl, -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, —O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 The cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl may optionally be selected from halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2-(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and - (C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl).

[0095] Preferably, R C4 is hydrogen, halo, C 1~6 Alkyl, C 2~6 Alkynyl, -O(C 1~6 alkyl), -S(C 1~6 alkyl), -NH(C 1~6 alkyl), C 1~6 Haloalkyl, -(C 0~3 alkylene)-cycloalkyl, -(C 0~3 alkylene)-cycloalkenyl, -(C 0~3 alkylene)-heterocycloalkyl, -(C 0~3 alkylene)-heterocycloalkenyl, -(C 0~3 alkylene)-aryl and -(C 0~3 alkylene)-heteroaryl, preferably selected from hydrogen, halo, C 1~6 Alkyl, C 2~6 Alkynyl, -O(C 1~6 alkyl), -S(C 1~6 alkyl), -NH(C 1~6 alkyl), C 1~6 Haloalkyl, -(C 0~3 alkylene)-cycloalkyl, -(C 0~3 alkylene)-heterocycloalkyl, -(C 0~3 alkylene)-aryl and -(C 0~3 The alkyl or alkynyl (preferably alkyl) may optionally be selected from the group consisting of halogen, —CN, —OH, —O(C 1~5 alkyl), -O(C 1~5 haloalkyl), C 1~5 Haloalkyl, -SH, -S(C 1~5 alkyl), -S(C 1~5haloalkyl), -NH2-NH(C 1~5 alkyl)-NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, —O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -O(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5The cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl may optionally be selected from halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl)-N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 haloalkyl), -S(C 1~5 alkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl).

[0096] More preferably, R C4 is hydrogen, halo, C 1~6 Alkyl, C 2~6 Alkynyl, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -NH-C 1~6 Alkyl, and C 1~6 haloalkyl, more preferably R C4 is hydrogen, halo, C 1~2 Alkyl, and C 2~3 alkynyl, and even more preferably R C4 are hydrogen, halo, and C 1~2 alkyl, and even more preferably R C4 is hydrogen or halo.

[0097] In another preferred embodiment, R C4is -(C 0~3 alkylene)-cycloalkyl, -(C 0~3 alkylene)-cycloalkenyl, -(C 0~3 alkylene)-heterocycloalkyl, -(C 0~3 alkylene)-heterocycloalkenyl, -(C 0~3 alkylene)-aryl and -(C 0~3 alkylene)-heteroaryl, preferably -(C 0~3 alkylene)-cycloalkyl, -(C 0~3 alkylene)-heterocycloalkyl, -(C 0~3 alkylene)-aryl and -(C 0~3 The cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl may optionally be selected from the group consisting of halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-NH2-(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2. -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl). More preferably, R C4 is -(C 0~3 alkylene)-cycloalkyl, -(C 0~3 alkylene)-heterocycloalkyl, and -(C 0~3alkylene)-heteroaryl, preferably selected from cycloalkyl, heterocycloalkyl, and heteroaryl. The cycloalkyl, heterocycloalkyl, or heteroaryl may optionally be selected from halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -NH(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl). Even more preferably, R C4 is selected from heterocycloalkyl and heteroaryl. Heterocycloalkyl or heteroaryl may optionally be selected from halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -NH(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 and substituted with one or more groups independently selected from alkyl.

[0098] In another preferred embodiment, R C4 is selected from -CH2-cycloalkyl, -CH2-cycloalkenyl, -CH2-heterocycloalkyl, -CH2-heterocycloalkenyl, -CH2-aryl and -CH2-heteroaryl, preferably selected from -CH2-cycloalkyl, -CH2-heterocycloalkyl, -CH2-aryl and -CH2-heteroaryl. Cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl may optionally be selected from halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl). More preferably, R C4 is selected from -CH2-heterocycloalkyl and -CH2-heteroaryl. Heterocycloalkyl or heteroaryl may optionally be selected from halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 and substituted with one or more groups independently selected from alkyl.

[0099] R C4 When is heteroaryl, R C4 is preferably imidazolyl, pyridazinyl, thiazolyl, pyridinyl, pyrimidinyl, pyrazinyl or indazolyl, and heteroaryl is optionally selected from halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl)-NH(C 1~5 haloalkyl)-N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl)-NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl).

[0100] R C4 When R is heterocycloalkyl, C4is preferably morpholinyl, 1,1-dioxothiomorpholinyl, azetinyl, pyrrolidinyl, piperidinyl, 6-oxo-1,6-dihydropyridinyl, or piperazinyl, and heterocycloalkyl is optionally selected from halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), -CON(C 1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl). More preferably, R C4 is piperazinyl, optionally containing halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, CONH(C 1~5 alkyl), -CON(C1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl). Even more preferably, optionally R C4 -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 Most preferably, R is N-substituted (preferably N-substituted) piperazinyl (preferably N-piperazinyl). C4 is -CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably piperazinyl (preferably N-piperazinyl) substituted (preferably N-substituted, preferably substituted by an N atom different from the N atom attached to the ring system shown in formula (I)) by -CON(CH).

[0101] R C4 When R is heterocycloalkenyl, C4 is oxacyclohexenyl or azacyclohexenyl, preferably R C4 is azacyclohexenyl, and heterocycloalkenyl is optionally selected from halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -(N-heterocycloalkyl), -CO(C 1~5 alkyl), -CONH2, CONH(C 1~5 alkyl), -CON(C1~5 Alkyl)(C 1~5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C 1~5 alkyl), -N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -NHCONH2, -NHCONH-(C 1~5 alkyl), -NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 alkyl)CONH2, -N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CN, -(C 1~5 alkylene)-OH, -(C 1~5 alkylene)-O(C 1~5 alkyl), -(C 1~5 alkylene)-O(C 1~5 haloalkyl), -(C 1~5 alkylene)-SH, -(C 1~5 alkylene)-S(C 1~5 alkyl), -(C 1~5 alkylene)-S(C 1~5 haloalkyl), -(C 1~5 alkylene)-NH2, -(C 1~5 alkylene)-NH(C 1~5 alkyl), -(C 1~5 alkylene)-NH(C 1~5 haloalkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 Alkyl)(C 1~5 haloalkyl), -(C 1~5 alkylene)-(N-heterocycloalkyl), -(C 1~5 alkylene)-N(C 1~5 haloalkyl)(C 1~5 alkyl), -(C 1~5alkylene)-CO(C 1~5 alkyl), -(C 1~5 alkylene)-CONH2, -(C 1~5 alkylene)-CONH(C 1~5 alkyl), -(C 1~5 alkylene)-CON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-CO-(N-heterocycloalkyl), -(C 1~5 alkylene)-NHCO-(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)-CO-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCONH2, -(C 1~5 alkylene)-NHCONH-(C 1~5 alkyl), -(C 1~5 alkylene)-NHCON(C 1~5 Alkyl)(C 1~5 alkyl), -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH2, -(C 1~5 alkylene)-N(C 1~5 alkyl)CONH-(C 1~5 alkyl), and -(C 1~5 alkylene)-N(C 1~5 alkyl)CON(C 1~5 Alkyl)(C 1~5 substituted by one or more groups independently selected from alkyl, preferably halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl).

[0102] R C4 In another preferred embodiment, where R is heterocycloalkyl, C4 are 2-oxaspiro[3.5]non-6-en-7-yl, 2-oxaspiro[3.5]non-7-yl, 2-oxa-8-azaspiro[4.5]dec-8-yl, 9-oxa-3-azaspiro[5.5]undec-3-yl, 2-oxa-6-azaspiro[3.4]oct-6-yl, 1-oxa-7-azaspiro[3.5]non-7-yl, 1-oxa-8-azaspiro[4.5]dec-8-yl, 6-oxa-2-azaspiro[3.3]hept-2-yl, 2,8-diazo-2-azamis ... azaspiro[4.5]dec-8-yl, 7-oxa-3-azabicyclo[3.3.0]oct-3-yl, 8-oxa-3-azabicyclo[4.3.0]non-3-yl, 2-oxa-6-azaspiro[3.5]non-6-yl, 7-oxo-3,6,8-triazabicyclo[4.3.0]non-3-yl, 3-pyrrolino[3,4-c]pyrazol-2-yl, 3,6-diazabicyclo[3.1.1]hept-3-yl, or 2,7-diazaspiro[3.5]non-7-yl.

[0103] Preferably, when X2 comprises cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, X4 is CR C4 and R C4 is hydrogen, halo, C 1~6 Alkyl, -O(C 1~6 alkyl), -S(C 1~6 alkyl), -NH(C 1~6 alkyl) and C 1~6 More preferably, when X2 comprises cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, X4 is selected from CR C4 and R C4 is selected from hydrogen and halo.

[0104] More preferably, when X4 comprises a cycloalkyl, heterocycloalkyl, aryl or heteroaryl, X2 does not comprise any of a cycloalkyl, heterocycloalkyl, aryl and heteroaryl group.

[0105] More preferably, when X2 comprises a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl and X4 comprises a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, R C4 and -Y C2 -R C2 together contain no more than 12 non-hydrogen atoms, preferably no more than 10 non-hydrogen atoms.

[0106] X5 is N or CR C5 Preferably, no more than one of X4 and X5 is N. In certain preferred embodiments, X4 is N and X5 is CR C5 and preferably X4 is N and X5 is CH. In certain preferred embodiments, X4 is CR C4 and X5 is N, preferably X4 is CH and X5 is N. In certain preferred embodiments, X4 is CR C4 and X5 is CR C5 In certain preferred embodiments, X4 is CH and X5 is CH.

[0107] R C5 is hydrogen, halo, C 1~6 Alkyl, -O(C 1~6 alkyl), -S(C 1~6 alkyl), -NH(C 1~6 alkyl), -N(C 1~6 Alkyl)C 1~6 Alkyl and C 1~6 haloalkyl. Preferably, R C5 is hydrogen, halo, C 1~3 Alkyl, -O(C 1~3 alkyl), -S(C 1~3 alkyl), -NH(C 1~3 alkyl), and C1~3 haloalkyl. More preferably, R C5 is hydrogen, halo, C 1~3 Alkyl and C 1~3 haloalkyl.

[0108] R4 is Y R5 -R R5 is.

[0109] Y R5 is a covalent bond, C 1~4 Alkylene, C 2~4 Alkenylene, and C 2~4 Alkynylene, alkylene, alkenylene, and alkynylene are each optionally selected from halogen, —CN, —OH, —O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -SO(C 1~5 alkyl), -SO2(C 1~5 alkyl), -S(C 1~5 haloalkyl), -SO(C 1~5 haloalkyl), -SO2(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), and -N(C 1~5 haloalkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, —O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -S(C 1~5 alkyl), -SO(C 1~5 alkyl), -SO2(C 1~5 alkyl), -S(C 1~5 haloalkyl), -SO(C 1~5 haloalkyl), -SO2(C 1~5 haloalkyl), -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C1~5 Alkyl)(C 1~5 alkyl), and -N(C 1~5 haloalkyl)(C 1~5 alkyl), more preferably halogen, —CN, —OH, —O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), and -N(C 1~5 haloalkyl)(C 1~5 alkyl), and further, one or more —CH units contained in the alkylene, alkenylene, or alkynylene are each optionally selected from —O—, NH—, N(C 1~5 and is substituted by a group independently selected from -O-, NH-, N(C alkyl)-, CO-, -COO-, S-, -SO-, and SO-, and preferably is substituted by a group independently selected from -O-, NH-, N(C alkyl)-, -COO-, S-, -SO-, and SO-. 1~5 Preferably, Y is selected from the group consisting of -, -CO-, -S-, -SO-, and -SO2-. R5 is a covalent bond, C 1~2 Alkylene, -CO-(C 1~2 alkylene)-, -(C 1~2 alkylene)-CO-, -CONH-(C 1~2 alkylene)-, -(C 1~2 alkylene)-CONH,-NHCO-(C 1~2 alkylene)-, -(C 1~2 alkylene)-NHCO-, -NH-(C 1~2 alkylene)-, -(C 1~2 alkylene)-NH-, -O-(C 1~2 alkylene)-, -(C 1~2 alkylene)-O-, SO2-(C 1~2 alkylene)-, -(C 1~2 alkylene)SO2-, -CONH-, CON(C 1~5 alkyl)-, -NHCO-, -N(C 1~5C is selected from the group consisting of -CO-, -NH-, -O-, -CO-, -COO- and -SO2-. 1~2 Alkylene as used herein is preferably a -CH2- group.

[0110] R R5 is C1~ 12 Alkyl, C2~ 12 Alkenyl, C2~ 12 alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl, preferably C1 to 12 Alkyl, C2~ 12 Alkenyl, C2~ 12 is selected from alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl. Preferably, R R5 is selected from cycloalkyl, heterocycloalkyl, aryl and heteroaryl. More preferably, R R5 is selected from heterocycloalkyl, aryl, and heteroaryl. Even more preferably, R R5 is selected from aryl and heteroaryl. Most preferably, R R5 is heteroaryl. The alkyl, alkenyl, or alkynyl may optionally be a halogen, —CN, —OH, —O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), NH 21 , NH(C 1~5 alkyl), NH(C 1~5 haloalkyl), N(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 haloalkyl)(C 1~5 alkyl), CONH2, CONH(C 1~5 alkyl), and CON(C 1~5 Alkyl)(C 1~5The cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl is optionally substituted with one or more groups independently selected from halogen, —CN, —OH, —C 1~5 Alkyl, -C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -SO(C 1~5 alkyl), -SO2(C 1~5 alkyl), -S(C 1~5 haloalkyl), -SO(C 1~5 haloalkyl), -SO2(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, —CN, —OH, —C 1~5 Alkyl, -C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl).

[0111] Preferably, Y R5 is a covalent bond, C 1~2 Alkylene, -CO-(C 1~2 alkylene)-, -(C 1~2 alkylene)-CO-, -CONH-(C 1~2 alkylene)-, -(C 1~2 alkylene)-CONH-, -NHCO-(C 1~2 alkylene)-, -(C 1~2 alkylene)-NHCO-, -NH-(C 1~2 alkylene)-, -(C 1~2 alkylene)-NH-, -O-(C 1~2 alkylene)-, -(C 1~2 alkylene)-O-, SO2-(C 1~2 alkylene), -(C 1~2 alkylene)SO2-, -CONH-, -NHCO-, -NH-, -O-, -CO and SO2-. Thus, preferably, R4 is selected from -(C 0~2 alkylene)-cycloalkyl, -CO-(C 0~2 alkylene)-cycloalkyl, -(C 0~2 alkylene)-CO-cycloalkyl, -CONH-(C 0~2 alkylene)-cycloalkyl, -(C 0~2 alkylene)-CONH-cycloalkyl, -NHCO-(C 0~2 alkylene)-cycloalkyl, -(C 0~2 alkylene)-NHCO-cycloalkyl, -NH-(C 0~2 alkylene)-cycloalkyl, -(C 0~2 alkylene)-NH-cycloalkyl, -O-(C 0~2 alkylene)-cycloalkyl, -(C 0~2 alkylene)-O-cycloalkyl, SO2-(C 0~2 alkylene)-cycloalkyl, -(C 0~2 alkylene)SO2-cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, SO2-cycloalkyl, -(C 0~2alkylene)-cycloalkenyl, -CO-(C 0~2 alkylene)-cycloalkenyl, -(C 0~2 alkylene)-CO-cycloalkenyl, -CONH-(C 0~2 alkylene)-cycloalkenyl, -(C 0~2 alkylene)-CONH-cycloalkenyl, -NHCO-(C 0~2 alkylene)-cycloalkenyl, -(C 0~2 alkylene)-NHCO-cycloalkenyl, -NH-(C 0~2 alkylene)-cycloalkenyl, -(C 0~2 alkylene)-NH-cycloalkenyl, -O-(C 0~2 alkylene)-cycloalkenyl, -(C 0~2 alkylene)-O-cycloalkenyl, SO2-(C 0~2 alkylene)-cycloalkenyl, -(C 0~2 alkylene)SO2-cycloalkenyl, -CONH-cycloalkenyl, -NHCO-cycloalkenyl, -NH-cycloalkenyl, -O-cycloalkenyl, -CO-cycloalkenyl, SO2-cycloalkenyl, -(C 0~2 alkylene)-heterocycloalkyl, -CO(C 0~2 alkylene)-heterocycloalkyl, -(C 0~2 alkylene)-CO-heterocycloalkyl, -CONH-(C 0~2 alkylene)-heterocycloalkyl, -(C 0~2 alkylene)-CONH-heterocycloalkyl, -NHCO-(C 0~2 alkylene)-heterocycloalkyl, -(C 0~2 alkylene)-NHCO-heterocycloalkyl, -NH-(C 0~2 alkylene)-heterocycloalkyl, -(C 0~2 alkylene)-NH-heterocycloalkyl, -O-(C 0~2 alkylene)-heterocycloalkyl, -(C 0~2 alkylene)-O-heterocycloalkyl, SO2-(C 0~2 alkylene)-heterocycloalkyl, -(C 0~2alkylene)SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, SO2-heterocycloalkyl, -(C 0~2 alkylene)-heterocycloalkenyl, -CO-(C 0~2 alkylene)-heterocycloalkenyl, -(C 0~2 alkylene)-CO-heterocycloalkenyl, -CONH-(C 0~2 alkylene)-heterocycloalkenyl, -(C 0~2 alkylene)-CONH-heterocycloalkenyl, -NHCO-(C 0~2 alkylene)-heterocycloalkenyl, -(C 0~2 alkylene)-NHCO-heterocycloalkenyl, -NH-(C 0~2 alkylene)-heterocycloalkenyl, -(C 0~2 alkylene)-NH-heterocycloalkenyl, -O-(C 0~2 alkylene)-heterocycloalkenyl, -(C 0~2 alkylene)-O-heterocycloalkenyl, SO2-(C 0~2 alkylene)-heterocycloalkenyl, -(C 0~2 alkylene)SO2-heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, -CO-heterocycloalkenyl, -SO2-heterocycloalkenyl, -(C 0~2 alkylene)-aryl, -CO-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)-CO-aryl, -CONH-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)-CONH-aryl, -NHCO-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)-NHCO-aryl, -NH(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)-NH-aryl, -O-(C0~2 alkylene)-aryl, -(C 0~2 alkylene)-O-aryl, SO2-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, SO2-aryl, -(C 0~2 alkylene)-heteroaryl, -CO-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-CO-heteroaryl, -CONH-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-CONH-heteroaryl, -NHCO-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-NHCO-heteroaryl, -NH-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-NH-heteroaryl, -O-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-O-heteroaryl, SO2-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl, and SO2-heteroaryl, preferably -(C 0~2 alkylene)-cycloalkyl, -CO-(C 0~2 alkylene)-cycloalkyl, -(C 0~2 alkylene)-CO-cycloalkyl, -CONH-(C 0~2 alkylene)-cycloalkyl, -(C 0~2 alkylene)-CONH-cycloalkyl, -NHCO-(Co-2 alkylene)-cycloalkyl, -(C 0~2 alkylene)-NHCO-cycloalkyl, -NH-(C 0~2 alkylene)-cycloalkyl, -(C 0~2alkylene)-NH-cycloalkyl, -O-(C 0~2 alkylene)-cycloalkyl, -(C 0~2 alkylene)-O-cycloalkyl, SO2-(C 0~2 alkylene)-cycloalkyl, -(C 0~2 alkylene)SO2-cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, SO2-cycloalkyl, -(C 0~2 alkylene)-heterocycloalkyl, -CO-(C 0~2 alkylene)-heterocycloalkyl, -(C 0~2 alkylene)-CO-heterocycloalkyl, -CONH-(C 0~2 alkylene)-heterocycloalkyl, -(C 0~2 alkylene)-CONH-heterocycloalkyl, -NHCO-(C 0~2 alkylene)-heterocycloalkyl, -(C 0~2 alkylene)-NHCO-heterocycloalkyl, -NH(C 0~2 alkylene)-heterocycloalkyl, -(C 0~2 alkylene)-NH-heterocycloalkyl, -O-(C 0~2 alkylene)-heterocycloalkyl, -(C 0~2 alkylene)-O-heterocycloalkyl, SO2-(C 0~2 alkylene)-heterocycloalkyl, -(C 0~2 alkylene)SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, SO2-heterocycloalkyl, -(C 0~2 alkylene)-aryl, -CO-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)-CO-aryl, -CONH-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)-CONH-aryl, -NHCO-(C 0~2 alkylene)-aryl, -(C0~2 alkylene)-NHCO-aryl, -NH-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)-NH-aryl, -O-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)-O-aryl, SO2-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, SO2-aryl, -(C 0~2 alkylene)-heteroaryl, -CO-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-CO-heteroaryl, -CONH-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-CONH-heteroaryl, -NHCO-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-NHCO-heteroaryl, -NH-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-NH-heteroaryl, -O-(C 0~2 alkylene)-heteroaryl, -(C 0~2 a alkylene)-O-heteroaryl, SO2-(C 0~2 alkylene)-heteroaryl, -(C 0~2 The cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl is optionally selected from halogen, —CN, —OH, —C ... 1~5 Alkyl, -C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5alkyl), -SO(C 1~5 alkyl), -SO2(C 1~5 alkyl), -S(C 1~5 haloalkyl), -SO(C 1~5 haloalkyl), -SO2(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, CN, OH, C 1~5 Alkyl, C 1~5 Haloalkyl, O(C 1~5 alkyl), O(C 15 haloalkyl), SH, S(C 15 alkyl), S(C 15 haloalkyl), NH2, NH(C 1~5 alkyl), NH(C 15 haloalkyl), N(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 haloalkyl)(C 1~5 alkyl), CONH2, CONH(C 1~5 alkyl), and CON(C 1~5 Alkyl)(C 1~5 More preferably, R4 is selected from -(C 0~2 alkylene)-aryl, -CO-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)-CO-aryl, -CONH-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)-CONH-aryl, -NHCO-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)-NHCO-aryl, -NH-(C0~2 alkylene)-aryl, -(C 0~2 alkylene)-NH-aryl, -O-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)-O-aryl, SO2-(C 0~2 alkylene)-aryl, -(C 0~2 alkylene)SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, SO2-aryl, -(C 0~2 alkylene)-heteroaryl, -CO-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-CO-heteroaryl, -CONH-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-CONH-heteroaryl, -NHCO-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-NHCO-heteroaryl, -NH-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-NH-heteroaryl, -O-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)-O-heteroaryl, SO2-(C 0~2 alkylene)-heteroaryl, -(C 0~2 alkylene)SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl, and SO2-heteroaryl, wherein aryl or heteroaryl is optionally selected from halogen, -CN, -OH, -C 1~5 Alkyl, -C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -SO(C 1~5 alkyl), -SO2(C 1~5 alkyl), -S(C 1~5 haloalkyl), -SO(C1~5 haloalkyl), -SO2(C 1~5 haloalkyl), -NH2-NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, CN, OH, C 1~5 Alkyl, C 1~5 Haloalkyl, O(C 1~5 alkyl), O(C 15 haloalkyl), SH, S(C 15 alkyl), S(C 15 haloalkyl), NH2, NH(C 1~5 alkyl), NH(C 15 haloalkyl), N(C 1~5 Alkyl)(C 1~5 alkyl), N(C 1~5 haloalkyl)(C 1~5 alkyl), CONH2, CONH(C 1~5 alkyl), and CON(C 1~5 Alkyl)(C 1~5 alkyl).

[0112] In certain embodiments, R4 is -(C 0~2 alkylene)-CO-cycloalkyl, preferably -CO-cyclohexyl, and -(C 0~2 alkylene)-CO-aryl, preferably -CO-phenyl.

[0113] In certain embodiments, R4 is -COO-(C 1~5 alkyl) or -CONH-(C 1~5 alkyl).

[0114] In one particular embodiment, R4 is:

[0115] [ka]

[0116] is selected from.

[0117] Preferably, Y R5 is a covalent bond. Therefore, R4 is preferably C 1~12 Alkyl, C2~ 12 Alkenyl, C2~ 12 is selected from alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl, more preferably C 1~12 Alkyl, C2~ 12 Alkenyl, C2~ 12 R4 is selected from alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl. More preferably, R4 is selected from cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl. More preferably, R4 is selected from cycloalkyl, heterocycloalkyl, aryl, and heteroaryl. Even more preferably, R4 is selected from aryl and heteroaryl. Most preferably, R4 is heteroaryl. The alkyl, alkenyl, or alkynyl may optionally be selected from halogen, -CN, -OH, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5The cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl is optionally substituted with one or more groups independently selected from halogen, —CN, —OH, —C 1~5 Alkyl, -C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -SO(C 1~5 alkyl), -SO2(C 1~5 alkyl), -S(C 1~5 haloalkyl), -SO(C 1~5 haloalkyl), -SO2(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 and substituted with one or more groups independently selected from alkyl.

[0118] Preferably, R4 is optionally selected from halogen, —CN, —OH, —C 1~5 Alkyl, -C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -SO(C 1~5 alkyl), -SO2(C 1~5 alkyl), -S(C 1~5 haloalkyl), -SO(C 1~5 haloalkyl), -SO2(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5and 5-membered heteroaryl substituted by one or more groups independently selected from the group consisting of imidazolyl, isoxazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, thiazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, and 1,3,4-thiadiazolyl. More preferably, the 5-membered heteroaryl is 1,2,4-thiadiazolyl, optionally substituted with one or more groups independently selected from halogen, —CN, —OH, —C 1~5 Alkyl, -C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -SO(C 1~5 alkyl), -SO2(C 1~5 alkyl), -S(C 1~5 haloalkyl), -SO(C 1~5 haloalkyl), -SO2(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -SH, -S(C 1~5 alkyl), -NH2, -NH(C 1~5 alkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5alkyl), and preferably optionally substituted by one or more groups independently selected from C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -SH, -S(C 1~5 alkyl), more preferably optionally substituted by C 1~5 Alkyl, C 1~5 substituted by haloalkyl, even more preferably C 1~5 Substituted by haloalkyl, preferably selected from -CH2F, -CHF2 and CF3, most preferably optionally substituted by -CHF2.

[0119] In one particular embodiment, R4 is

[0120] [ka]

[0121] is.

[0122] Preferably, the present invention relates to compounds of formula (I), wherein W is -NHS(O)2-. Thus, in another embodiment, the present invention relates to compounds of formula (Ia):

[0123] [ka]

[0124] The present invention relates to the compound

[0125] R1, R2, R3, R4, X1, X2, X3, X4 and X5 in the compounds of formula (Ia) are as defined above for the compounds of formula (I).

[0126] In a preferred embodiment, R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl. Thus, preferably, the compound of formula (Ia) has the formula (Ib):

[0127] [ka]

[0128] is a compound of

[0129] R1, R4, X1, X2, X3, X4, and X5 in compounds of formula (Ib) are as defined above for compounds of formula (I).

[0130] R1 is hydrogen, chloro, fluoro, cyano, formyl, (C 1~2 ) alkyl, (C2) alkenyl, (C2) alkynyl (C 1~2 ) haloalkyl, -(C 1~2 alkylene)-OH and -(C 1~2 alkylene)-O-(C 1~2 Preferably, R1 is selected from the group consisting of hydrogen, chloro, fluoro, cyano, formyl, (C 1~2 ) alkyl, (C2) alkenyl, (C2) alkynyl and (C 1~2 More preferably, R1 is selected from the group consisting of cyano, (C1-2)haloalkyl, and (C 1~2 ) alkyl, preferably selected from the group consisting of cyano, fluoromethyl and methyl. More preferably, R1 is cyano. Thus, in a preferred embodiment, the compound of formula (Ib) is of formula (Ic):

[0131] [ka]

[0132] is a compound of

[0133] R4, X1, X2, X3, X4, and X5 in compounds of formula (Ic) are as defined above for compounds of formula (I).

[0134] Also included within the scope of the present invention are compounds of formula (I) or compounds of formula (Ia) or compounds of formula (Ib) in which R1 is methyl. In certain preferred embodiments of the present invention, R1 is methyl. Also included within the scope of the present invention are compounds of formula (I) or compounds of formula (Ia) or compounds of formula (Ib) in which R1 is fluoromethyl. In certain preferred embodiments of the present invention, R1 is fluoromethyl.

[0135] Preferably, within the scope of the present invention, X1 and X3 are each CH. Thus, preferably, the compounds of formula (I) of the present invention have the formula (Id):

[0136] [ka]

[0137] is a compound of

[0138] W, R1, R2, R3, R4, X2, X4, and X5 in compounds of formula (Id) are as defined above for compounds of formula (I).

[0139] Preferably, the present invention relates to a compound of formula (I), wherein W is -NHS(O)2-. Thus, preferably, the compound of formula (Id) of the present invention is a compound of formula (Ie):

[0140] [ka]

[0141] is a compound of

[0142] R1, R2, R3, R4, X2, X4, and X5 in the compounds of formula (Ie) are as defined above for the compounds of formula (I).

[0143] In a preferred embodiment, R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl. Thus, preferably, the compound of formula (Ie) of the present invention has the formula (If):

[0144] [ka]

[0145] is a compound of

[0146] R1, R4, X2, X4, and X5 in the compounds of formula (If) are as defined above for the compounds of formula (I) of the present invention.

[0147] Within the scope of the present invention, R1 is preferably hydrogen, chloro, fluoro, cyano, formyl, (C 1~2 ) alkyl, (C2) alkenyl, (C2) alkynyl and (C 1~2 ) haloalkyl. More preferably, R1 is selected from the group consisting of cyano, (C 1~2 ) haloalkyl and (C 1~2 ) alkyl, preferably selected from the group consisting of cyano, fluoromethyl and methyl. More preferably, R1 is cyano.

[0148] Thus, preferably, the compound of formula (If) of the present invention has the formula (ig):

[0149] [ka]

[0150] is a compound of

[0151] R4, X2, X4, and X5 in the compounds of formula (Ig) are as defined above for the compounds of formula (I) of the present invention.

[0152] Also included within the scope of the present invention are compounds of formula (Id) or compounds of formula (Ie) or compounds of formula (If) in which R1 is methyl. In certain preferred embodiments of the present invention, R1 is methyl. Also included within the scope of the present invention are compounds of formula (Id) or compounds of formula (Ie) or compounds of formula (If) in which R1 is fluoromethyl. In certain preferred embodiments of the present invention, R1 is fluoromethyl.

[0153] As encompassed by the present invention, X4 is N or CR C4 and X5 is N or CR C5 Furthermore, as defined above, preferably no more than one of X4 and X5 is N. In certain embodiments of the invention, X5 is N. Thus, when X5 is N, preferably X4 is CR C4 Thus, in certain preferred embodiments, the compound of formula (I) has the formula (Ih):

[0154] [ka]

[0155] is a compound of

[0156] W, R in the compound of formula (Ih) C4 , R1, R2, Rs, R4, X1, X2 and X3 are as defined above for compounds of formula (I).

[0157] Preferably, within the scope of the present invention, W is -NHS(O)2-. Thus, preferably, the compound of formula (I) or the compound of formula (Ia) or the compound of formula (Ih) is a compound of formula (Ii):

[0158] [ka]

[0159] is a compound of

[0160] R in the compound of formula (Ii)C4 , R1, R2, R3, R4, X1, X2 and X3 are as defined above for compounds of formula (I).

[0161] In a preferred embodiment, R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl. Thus, preferably, the compound of formula (Ii) of the present invention has the formula (Ij):

[0162] [ka]

[0163] is a compound of

[0164] R in the compound of formula (Ij) C4 , R1, R4, X1, X2, and X3 are as defined above for compounds of formula (I).

[0165] Within the scope of the present invention, preferably R1 is hydrogen, chloro, fluoro, cyano, formyl, (C 1~2 ) alkyl, (C2) alkenyl, (C2) alkynyl and (C 1~2 ) haloalkyl. More preferably, R1 is cyano, (C 1~2 ) haloalkyl and (C 1~2 ) alkyl, preferably selected from the group consisting of cyano, fluoromethyl and methyl. More preferably, R1 is cyano.

[0166] Therefore, preferably within the scope of the present invention, the compounds of formula (I) or compounds of formula (Ib) or compounds of formula (Ic) or compounds of formula (Ih) or compounds of formula (Ii) or compounds of formula (Ij) of the present invention are compounds of formula (Ik):

[0167] [ka]

[0168] is a compound of

[0169] R in the compound of formula (Ik) C4 , R4, X1, X2, and X3 are as defined above for compounds of formula (I).

[0170] In one embodiment of the compound of formula (I) of the present invention, X1 and X3 are each CH. Thus, preferably, the compound of formula (I) of the present invention has the formula (IL):

[0171] [ka]

[0172] is a compound of

[0173] W, R in the compound of formula (IL) C4 , R1, R2, R3, R4, and X2 are as defined above for compounds of formula (I).

[0174] Preferably, within the scope of the present invention, W is -NHS(O)2-. Thus, preferably, the compounds of formula (IL) of the present invention have the formula (Im):

[0175] [ka]

[0176] is a compound of

[0177] R in the compound of formula (IL) C4 , R1, R2, R3, R4 and X2 are as defined above for compounds of formula (I).

[0178] Preferably, R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl. Thus, preferably, the compound of formula (Im) of the present invention has the formula (In):

[0179] [ka]

[0180] is a compound of

[0181] R in the compound of formula (In) C4 , R1, R4, and X2 are as defined above for compounds of formula (I).

[0182] Within the scope of the present invention, preferably R1 is hydrogen, chloro, fluoro, cyano, formyl, (C 1~2 ) alkyl, (C2) alkenyl, (C2) alkynyl and (C 1~2 ) haloalkyl. More preferably, R1 is selected from the group consisting of cyano, (C 1~2 ) haloalkyl and (C 1~2 ) alkyl, preferably selected from the group consisting of cyano, fluoromethyl and methyl. More preferably, R1 is cyano.

[0183] Therefore, preferably within the scope of the present invention, the compound of formula (In) is of formula (Io):

[0184] [ka]

[0185] is a compound of

[0186] R in the compound of formula (Io) C4 , R4 and X2 are as defined above for compounds of formula (I).

[0187] Also included within the scope of the present invention are compounds of formula (IL) or compounds of formula (Im) or compounds of formula (In) where R1 is methyl. In certain preferred embodiments of the present invention, R1 is methyl. Alternatively, also included within the scope of the present invention are compounds of formula (IL) or compounds of formula (Im) or compounds of formula (In) where R1 is fluoromethyl. In certain preferred embodiments of the present invention, R1 is fluoromethyl.

[0188] In one embodiment of the compound of formula (I) of the present invention, R4 is selected from aryl and heteroaryl. Most preferably, R4 is heteroaryl. Aryl or heteroaryl may optionally be selected from halogen, -CN, -OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2-NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 Preferably, R4 is substituted by one or more groups independently selected from halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5and 5-membered heteroaryl optionally substituted with one or more groups independently selected from: imidazolyl, isoxazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, thiazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, or 1,3,4-thiadiazolyl. More preferably, the 5-membered heteroaryl is 1,2,4-thiadiazolyl, optionally substituted with one or more groups independently selected from halogen, —CN, —OH, —C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), and preferably optionally substituted by one or more groups independently selected from C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -SH, -S(C 1~5 alkyl), more preferably optionally substituted by C 1~5 Alkyl, C 1~5 haloalkyl, and even more preferably optionally substituted by C 1~5 Substituted by haloalkyl, preferably selected from -CH2F, -CHF2 and CF3, most preferably optionally substituted by -CHF2.

[0189] Thus, in a preferred embodiment, the compound of formula (I) has the formula (Ip):

[0190] [ka]

[0191] is a compound of

[0192] W, R1, R2, R3, X1, X2, X3, X4, and X5 in compounds of formula (Ip) are as defined above for compounds of formula (I).

[0193] Preferably, W is -NHS(O)2-. Thus, within the scope of the present invention, compounds of formula (Ip) may also be compounds of formula (Iq):

[0194] [ka]

[0195] is a compound of

[0196] R1, R2, R3, X1, X2, X3, X4, and X5 in the compounds of formula (Io) are as defined above for the compounds of formula (I).

[0197] In a further preferred embodiment, R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl. Thus, in a preferred embodiment, the compound of formula (Iq) of the present invention has the formula (Ir):

[0198] [ka]

[0199] is a compound of

[0200] R1, X1, X2, X3, X4, and X5 in the compounds of formula (Ir) are as defined above for the compounds of formula (I).

[0201] More preferably, R1 is hydrogen, chloro, fluoro, cyano, formyl, (C 1~2 ) alkyl, (C2) alkenyl, (C2) alkynyl and (C 1~2 ) haloalkyl. Preferably, R1 is selected from the group consisting of cyano, (C 1~2 ) haloalkyl and (C 1~2 ) alkyl, preferably selected from the group consisting of cyano, fluoromethyl and methyl. More preferably, R1 is cyano.

[0202] Therefore, preferably within the scope of the present invention, compounds of formula (Ir) are those of formula (Is):

[0203] [ka]

[0204] is a compound of

[0205] X1, X2, X3, X4, and X5 in compounds of formula (Ir) are as defined above for compounds of formula (I).

[0206] It should be noted that the scope of the present invention also includes compounds of formula (Ip) or compounds of formula (Iq) or compounds of formula (Ir) in which R1 is methyl. In certain preferred embodiments of the present invention, R1 is methyl. It should further be noted that the scope of the present invention also includes compounds of formula (Ip) or compounds of formula (Iq) or compounds of formula (Ir) in which R1 is fluoromethyl. In certain preferred embodiments of the present invention, R1 is fluoromethyl.

[0207] Further preferred within the scope of the present invention are embodiments in which X1 and X3 are each CH.

[0208] Thus, the compounds of formula (Ip) of the present invention further comprise compounds of formula (Ip) of formula (It):

[0209] [ka]

[0210] The present invention relates to an embodiment in which the compound is

[0211] W, R1, R2, R3, X2, X4, and X5 in compounds of formula (It) are as defined above for compounds of formula (I).

[0212] Preferably, W is -NHS(O)2-. Therefore, further within the scope of the present invention, the compounds of formula (Iq) of the present invention further comprise the compounds of formula (Iu)

[0213] [ka]

[0214] The present invention relates to an embodiment in which the compound is

[0215] R1, R2, R3, X2, X4, and X5 in the compounds of formula (Iu) are as defined above for the compounds of formula (I).

[0216] Preferably, in compounds of formula (Iu), R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl.

[0217] Therefore, as further encompassed by the present invention, the compound of formula (Ir) of the present invention may further comprise a compound of formula (Ir) of formula (Iv):

[0218] [ka]

[0219] The present invention relates to an embodiment in which the compound is

[0220] R1, X2, X4, and X5 in the compounds of formula (Iv) are as defined above for the compounds of formula (I).

[0221] Preferably, R1 is cyano, and the compound of formula (Is) of the present invention further comprises the compound of formula (Iw):

[0222] [ka]

[0223] The present invention relates to an embodiment in which the compound is

[0224] X2, X4, and X5 in compounds of formula (Iw) are as defined above for compounds of formula (I).

[0225] Also included within the scope of the present invention are compounds of formula (It) or compounds of formula (Iu) or compounds of formula (Iv) in which R1 is methyl. In certain preferred embodiments of the present invention, R1 is methyl. Alternatively, also included within the scope of the present invention are compounds of formula (It) or compounds of formula (Iu) or compounds of formula (Iv) in which R1 is fluoromethyl. In certain preferred embodiments of the present invention, R1 is fluoromethyl.

[0226] As encompassed by the present invention, X4 is N or CR C4 and X5 is N or CR C5 Furthermore, as defined above, preferably no more than one of X4 and X5 is N. In certain embodiments of the invention, X5 is N. Thus, when X5 is N, preferably X4 is CR C4 Thus, in certain preferred embodiments, the compound of formula (It) has the formula (Ix):

[0227] [ka]

[0228] is a compound of

[0229] W and R in the compound of formula (Ix) C4, R1, R2, R3, and X2 are as defined above for compounds of formula (I).

[0230] Furthermore, and therefore preferably within the scope of the present invention, W is -NHS(O)2- and in a particularly preferred embodiment, the compound of formula (Iu) has the formula (Iy):

[0231] [ka]

[0232] is a compound of

[0233] R in the compound of formula (Iy) C4 , R1, R2, R3, and X2 are as defined above for compounds of formula (I).

[0234] Preferably, R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl. Thus, in further preferred embodiments, the compound of formula (Iv) has the formula (Iz):

[0235] [ka]

[0236] is a compound of

[0237] R in the compound of formula (Iz) C4 , R1, and X2 are as defined above for compounds of formula (I).

[0238] Within the scope of the present invention, preferably R1 is hydrogen, chloro, fluoro, cyano, formyl, (C 1~2 ) alkyl, (C2) alkenyl, (C2) alkynyl and (C 1~2 ) haloalkyl. More preferably, R1 is selected from the group consisting of cyano, (C 1~2 ) haloalkyl and (C 1~2) alkyl, preferably selected from the group consisting of cyano, fluoromethyl and methyl. More preferably, R1 is cyano. Thus, in a further particularly preferred embodiment, the compound of formula (Iw) is selected from the group consisting of formula (Iaa):

[0239] [ka]

[0240] is a compound of

[0241] R in the compound of formula (Iaa) C4 and X2 are as defined above for compounds of formula (I).

[0242] However, it should be noted that the scope of the present invention also includes compounds of formula (Ix) or compounds of formula (Iy) or compounds of formula (Iz) in which R1 is methyl. In certain preferred embodiments of the present invention, R1 is methyl. It should further be noted that the scope of the present invention also includes compounds of formula (Ix) or compounds of formula (Iy) or compounds of formula (Iz) in which R1 is fluoromethyl. In certain preferred embodiments of the present invention, R1 is fluoromethyl.

[0243] Preferably, within the scope of the present invention, X2 is CY C2 -R C2 Most preferably, Y C2 -R C2 is -CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably piperazinyl (preferably N-piperazinyl) substituted (preferably N-substituted, preferably at an N atom different from the N atom attached to the ring system shown in formula (I)) by —CON(CH3)2.

[0244] Thus, preferably, the compound of formula (I) of the present invention has the formula (Iab):

[0245] [ka]

[0246] is a compound of

[0247] W, R1, R2, R3, R4, X1, X3, X4 and X5 in the compounds of formula (Iab) are as defined for the compounds of formula (I) of the present invention.

[0248] Preferably, W is -NHS(O)2-. Thus, preferably, the compound of formula (Ia) or the compound of formula (Iab) of the present invention is a compound of formula (Iac):

[0249] [ka]

[0250] is a compound of

[0251] R1, R2, R3, R4, X1, X3, X4 and X5 in the compounds of formula (Iac) are as defined for the compounds of formula (I) of the present invention.

[0252] Preferably, R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl. Thus, more preferably, the compound of formula (Iac) or the compound of formula (Ib) of the present invention is a compound of formula (Iad):

[0253] [ka]

[0254] is a compound of

[0255] R1, R4, X1, X3, X4 and X5 in the compounds of formula (Iad) are as defined for the compounds of formula (I) of the present invention.

[0256] Therefore, further preferably, R1 is cyano, and therefore preferably the compound of formula (Ic) of the present invention or the compound of formula (Iad) of the present invention has the formula (Iae):

[0257] [ka]

[0258] is a compound of

[0259] R4, X1, X3, X4 and X5 in the compounds of formula (Iae) are as defined for the compounds of formula (I) of the present invention.

[0260] However, it should be noted that the scope of the present invention also includes compounds of formula (Iab) or compounds of formula (Iac) or compounds of formula (Iad) in which R1 is methyl. In certain preferred embodiments of the present invention, R1 is methyl. Alternatively, it should be noted that the scope of the present invention also includes compounds of formula (Iab) or compounds of formula (Iac) or compounds of formula (Iad) in which R1 is fluoromethyl. In certain preferred embodiments of the present invention, R1 is fluoromethyl.

[0261] Further preferred within the scope of the present invention are embodiments in which X1 and X3 are each CH.

[0262] Therefore, the compounds of formula (Iac) of the present invention preferably have the formula (Iag):

[0263] [ka]

[0264] is a compound of

[0265] W, R1, R2, R3, R4, X4 and X5 in the compounds of formula (Iaf) are as defined for the compounds of formula (I) of the present invention.

[0266] Preferably, W is -NHS(O)2-. Thus, further, the compounds of formula (Iad) or compounds of formula (Iaf) of the invention as defined herein preferably have the formula (Iag):

[0267] [ka]

[0268] is a compound of

[0269] R1, R2, R3, R4, X4 and X5 in the compounds of formula (Iag) are as defined for the compounds of formula (I) of the present invention.

[0270] Preferably, R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl. Thus, further, the compound of formula (Iae) or the compound of formula (Iag) of the present invention preferably has the formula (Iah):

[0271] [ka]

[0272] is a compound of

[0273] R1, R4, X4 and X5 in the compounds of formula (Iah) are as defined for the compounds of formula (I) of the present invention.

[0274] Preferably, R1 is cyano. Therefore, further, the compound of formula (Iaf) of the present invention or the compound of formula (Iah) of the present invention preferably has the formula (Iai):

[0275] [ka]

[0276] is a compound of

[0277] R4, X4 and X5 in the compounds of formula (Iai) are as defined for the compounds of formula (I) of the present invention.

[0278] Also included within the scope of the present invention are compounds of formula (Iaf) or compounds of formula (Iag) or compounds of formula (Iah) in which R1 is methyl. In certain preferred embodiments of the present invention, R1 is methyl. Alternatively, also included within the scope of the present invention are compounds of formula (Iaf) or compounds of formula (Iag) or compounds of formula (Iah) in which R1 is fluoromethyl. In certain preferred embodiments of the present invention, R1 is fluoromethyl.

[0279] As further encompassed by the present invention, X4 is N or CR C4 and X5 is N or CR C5 Furthermore, as defined above, preferably no more than one of X4 and X5 is N. In certain embodiments of the invention, X5 is N. Thus, when X5 is N, preferably X4 is CR C4 is.

[0280] Therefore, the compounds of formula (Iab) of the present invention preferably have the formula (Iaj):

[0281] [ka]

[0282] is a compound of

[0283] W and R in the compound of formula (Iaj) C4 , R1, R2, R3, R4, X1 and X3 are as defined for the compounds of formula (I) of the present invention.

[0284] W is preferably -NHS(O)2-. Therefore, further, the compound of formula (Iac) or the compound of formula (Iaj) of the present invention preferably has the formula (Iak):

[0285] [ka]

[0286] is a compound of

[0287] R in the compound of formula (Iak) C4 , R1, R2, R3, R4, X1 and X3 are as defined for the compounds of formula (I) of the present invention.

[0288] As disclosed herein, preferably, R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl. Thus, further, the compound of formula (Iad) or the compound of formula (Iak) of the present invention preferably has the formula (IaL):

[0289] [ka]

[0290] is a compound of

[0291] R in the compound of formula (IaL) C4 , R1, R4, X1, and X3 are as defined for the compounds of formula (I) of the present invention.

[0292] More preferably, R1 is cyano. Therefore, further, the compound of formula (Iae) or the compound of formula (IaL) of the present invention preferably has the formula (Iam):

[0293] [ka]

[0294] is a compound of

[0295] R in the compound of formula (Iam) C4 , R4, X1 and X3 are as defined for the compounds of formula (I) of the present invention.

[0296] Also included within the scope of the present invention are compounds of formula (Iaj) or compounds of formula (Iak) or compounds of formula (IaL) in which R1 is methyl. In certain preferred embodiments of the present invention, R1 is methyl. Also included within the scope of the present invention are compounds of formula (Iaj) or compounds of formula (Iak) or compounds of formula (IaL) in which R1 is fluoromethyl. In certain preferred embodiments of the present invention, R1 is fluoromethyl.

[0297] Therefore, furthermore, the compound of formula (Iaf) of the present invention preferably has the formula (Ian)

[0298] [ka]

[0299] is a compound of

[0300] W, R1, R2, R3, R4 and R in the compound of formula (Ian) C4 is as defined for the compounds of formula (I) of the present invention.

[0301] Therefore, furthermore, the compounds of formula (Iag) of the present invention preferably have the formula (Iao):

[0302] [ka]

[0303] is a compound of

[0304] R1, R2, R3, R4 and R in the compound of formula (Iao) C4 is as defined for the compounds of formula (I) of the present invention.

[0305] Therefore, furthermore, the compound of formula (Iah) of the present invention preferably has the formula (Iap):

[0306] [ka]

[0307] is a compound of

[0308] R1, R4, and R in the compound of formula (Iap) C4 is as defined for the compounds of formula (I) of the present invention.

[0309] Therefore, furthermore, the compound of formula (Iai) of the present invention preferably has the formula (Iaq):

[0310] [ka]

[0311] is a compound of

[0312] R4 and R in the compound of formula (Iaq) C4 is as defined for the compounds of formula (I) of the present invention.

[0313] As further encompassed by the present invention, X4 is N or CR C4 and X5 is N or CR C5 Furthermore, as defined above, preferably no more than one of X4 and X5 is N. In certain embodiments of the invention, X4 is N. Thus, when X4 is N, preferably X5 is CR C5 is.

[0314] Thus, in certain preferred embodiments of the present invention, the compounds of formula (I) of the present invention have the formula (Iar):

[0315] [ka]

[0316] is a compound of

[0317] W, R1, R2, R3, R4, X1, X2, X3, and R in the compound of formula (Iar)C5 is as defined for the compounds of formula (I) of the present invention.

[0318] Furthermore, W is therefore preferably -NHS(O)-, so that in certain preferred embodiments of the present invention, the compounds of formula (Ia) of the present invention have the formula (Ias):

[0319] [ka]

[0320] is a compound of

[0321] R1, R2, R3, R4, X1, X2, X3, and R in the compound of formula (Iar) C5 is as defined for the compounds of formula (I) of the present invention.

[0322] Further therefore, preferably R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl, so that in certain preferred embodiments of the present invention, compounds of formula (Ib) of the present invention have the formula (Iat):

[0323] [ka]

[0324] is a compound of

[0325] R1, R4, X1, X2, X3 and R in the compound of formula (Iat) C5 is as defined for the compounds of formula (I) of the present invention.

[0326] Furthermore, therefore, preferably R1 is cyano, so that in a particular preferred embodiment of the present invention, the compound of formula (Ic) of the present invention has the formula (Iau):

[0327] [ka]

[0328] is a compound of

[0329] R4, X1, X2, X3 and R in the compound of formula (Iau) C5 is as defined for the compounds of formula (I) of the present invention.

[0330] However, also included within the scope of the present invention are compounds of formula (Iar) or compounds of formula (Ias) or compounds of formula (Iat) in which R1 is methyl. In certain preferred embodiments of the present invention, R1 is methyl. Also included within the scope of the present invention are compounds of formula (Iar) or compounds of formula (Ias) or compounds of formula (Iat) in which R1 is fluoromethyl. In certain preferred embodiments of the present invention, R1 is fluoromethyl.

[0331] Furthermore, therefore, in certain preferred embodiments of the present invention, the compounds of formula (Id) of the present invention have the formula (Iav):

[0332] [ka]

[0333] is a compound of

[0334] W, R, R, R, R, X, and R in the compound of formula (Iav) C5 is as defined for the compounds of formula (I) of the present invention.

[0335] Furthermore, therefore, in certain preferred embodiments of the present invention, the compounds of formula (Ie) of the present invention have the formula (Iaw):

[0336] [ka]

[0337] is a compound of

[0338] R1, R2, R3, R4, X2 and R in the compound of formula (Iaw) C5 is as defined for the compounds of formula (I) of the present invention.

[0339] Furthermore, therefore, in certain preferred embodiments of the present invention, the compound of formula (If) of the present invention has the formula (Iax):

[0340] [ka]

[0341] is a compound of

[0342] R, R, X and R in the compound of formula (Iax) C5 is as defined for the compounds of formula (I) of the present invention.

[0343] Furthermore, therefore, in certain preferred embodiments of the present invention, the compounds of formula (Ig) of the present invention have the formula (Iay):

[0344] [ka]

[0345] is a compound of

[0346] R4, X2 and R in the compound of formula (Iay) C5 is as defined for the compounds of formula (I) of the present invention.

[0347] Furthermore, therefore, in certain preferred embodiments of the present invention, the compound of formula (Ip) of the present invention has the formula (Iaz):

[0348] [ka]

[0349] is a compound of

[0350] W, R1, R2, R3, X1, X2, X3, and R in the compound of formula (Iaz) C5 is as defined for the compounds of formula (I) of the present invention.

[0351] Furthermore, preferably therefore, W is -NHS(O)2-, so that in a particular preferred embodiment of the present invention, the compound of formula (Iq) of the present invention has the formula (Iba):

[0352] [ka]

[0353] is a compound of

[0354] R1, R2, R3, X1, X2, X3, and R in the compound of formula (Iba) C5 is as defined for the compounds of formula (I) of the present invention.

[0355] Further, therefore, preferably, R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl, so that in certain preferred embodiments of the present invention, the compound of formula (Ir) of the present invention has the formula (Ibb):

[0356] [ka]

[0357] is a compound of

[0358] R, X and R in the compound of formula (Ibb) C5 is as defined for the compounds of formula (I) of the present invention.

[0359] Furthermore, therefore, preferably R1 is cyano, so that in a particular preferred embodiment of the present invention, the compound of formula (Is) of the present invention has the formula (Ibc)

[0360] [ka]

[0361] is a compound of

[0362] Further preferred within the scope of the present invention are embodiments in which X1 and X3 are each CH. Thus, in certain preferred embodiments, compounds of formula (It) have the formula (Ibd):

[0363] [ka]

[0364] is a compound of

[0365] W, R, R, R, X and R in the compound of formula (Ibd) C5 is as defined for the compounds of formula (I) of the present invention.

[0366] Furthermore, therefore, in certain preferred embodiments of the present invention, the compound of formula (Iu) of the present invention has the formula (Ibe):

[0367] [ka]

[0368] is a compound of

[0369] R1, R2, R3, X2 and R in the compound of formula (Ibe) C5 is as defined for the compounds of formula (I) of the present invention.

[0370] Furthermore, therefore, in certain preferred embodiments of the present invention, the compound of formula (Iv) of the present invention is of formula (Ibf)

[0371] [ka]

[0372] is a compound of

[0373] R, X and R in the compound of formula (Ibf) C5 is as defined for the compounds of formula (I) of the present invention.

[0374] Furthermore, therefore, in certain preferred embodiments of the present invention, the compound of formula (Iw) of the present invention has the formula (Ibg):

[0375] [ka]

[0376] is a compound of

[0377] X2 and R in the compound of formula (Ibf) C5 is as defined for the compounds of formula (I) of the present invention.

[0378] In certain embodiments of the present invention, preferably, X2 is CY c2 -R c2 Most preferably, -Y c2 -R c2 is -CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably piperazinyl (preferably N-piperazinyl) substituted (preferably N-substituted, preferably at an N atom different from the N atom attached to the ring system shown in formula (I)) by —CON(CH3)2.

[0379] Thus, in certain preferred embodiments of the present invention, the compound of formula (Iab) has the formula (Ibh):

[0380] [ka]

[0381] is a compound of

[0382] W, R1, R2, R3, R4, X1, X3 and R in the compound of formula (Ibh) c5 is as defined for the compounds of formula (I) of the present invention.

[0383] Furthermore, therefore, in certain preferred embodiments of the present invention, the compound of formula (Iac) has the formula (Ibi):

[0384] [ka]

[0385] is a compound of

[0386] R1, R2, R3, R4, X1, X3 and R in the compound of formula (Ibi) C5 is as defined for the compounds of formula (I) of the present invention.

[0387] Furthermore, therefore, in certain preferred embodiments of the present invention, the compound of formula (Iad) has the formula (Ibj):

[0388] [ka]

[0389] is a compound of

[0390] R1, R4, X1, X3 and R in the compound of formula (Ibi) C5 is as defined for the compounds of formula (I) of the present invention.

[0391] Furthermore, therefore, in certain preferred embodiments of the present invention, the compound of formula (Iae) has the formula (Ibk):

[0392] [ka]

[0393] is a compound of

[0394] R4, X1, X3 and R in the compound of formula (Ibi) C5 is as defined for the compounds of formula (I) of the present invention.

[0395] Further preferred within the scope of the present invention are embodiments in which X1 and X3 are each CH. Thus, in certain preferred embodiments, compounds of formula (Iaf) have the formula (IbL):

[0396] [ka]

[0397] is a compound of

[0398] W, R1, R2, R3, R4 and R in the compound of formula (IbL) C5 is as defined for the compounds of formula (I) of the present invention.

[0399] Furthermore, therefore, in certain preferred embodiments of the present invention, the compound of formula (Iag) has the formula (Ibm):

[0400] [ka]

[0401] is a compound of

[0402] R1, R2, R3, R4 and R in the compound of formula (Ibm) C5 is as defined for the compounds of formula (I) of the present invention.

[0403] Furthermore, therefore, in certain preferred embodiments of the present invention, the compound of formula (Iah) has the formula (Ibn):

[0404] [ka]

[0405] is a compound of

[0406] R1, R4, and R in the compound of formula (Ibn) C5 is as defined for the compounds of formula (I) of the present invention.

[0407] Furthermore, therefore, in certain preferred embodiments of the present invention, the compound of formula (Iai) has the formula (Ibo):

[0408] [ka]

[0409] is a compound of

[0410] R4 and R in the compound of formula (Ibn) C5 is as defined for the compounds of formula (I) of the present invention.

[0411] In certain embodiments of the invention, X1 is CF and X3 is CH. Thus, compounds of formula (I) have the formula (Ibp):

[0412] [ka]

[0413] is a compound of

[0414] W, R1, R2, R3, R4, X2, X4, and X5 in compounds of formula (Ibp) are as defined above for compounds of formula (I).

[0415] Further, therefore, preferably W is -NHS(O) 2- Thus, in certain preferred embodiments of the present invention, the compound of formula (Ibp) of the present invention has the formula (Ibq):

[0416] [ka]

[0417] is a compound of

[0418] R1, R2, R3, R4, X2, X4, and X5 in compounds of formula (Ibq) are as defined above for compounds of formula (I).

[0419] Further, therefore, preferably, R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl, so that in certain preferred embodiments of the present invention, the compound of formula (Ibq) of the present invention has the formula (Ibr):

[0420] [ka]

[0421] is a compound of

[0422] R1, R4, X2, X4, and X5 in the compounds of formula (Ibr) are as defined above for the compounds of formula (I).

[0423] Furthermore, therefore, preferably R1 is cyano, so that in a particular preferred embodiment of the present invention, the compound of formula (Ibr) of the present invention has the formula (Ibs):

[0424] [ka]

[0425] is a compound of

[0426] R4, X2, X4, and X5 in the compounds of formula (Ibs) are as defined above for the compounds of formula (I).

[0427] However, it should be noted that compounds of formula (Ibp), (Ibq) or (Ibr) in which R1 is methyl or fluoromethyl are also included within the scope of the present invention.

[0428] In certain embodiments of the present invention, preferably, X2 is CY c2 -R c2 Most preferably, -Y c2 -R c2 is -CON(C 1~5 Alkyl)(C 1~5 alkyl), preferably piperazinyl (preferably N-piperazinyl) substituted (preferably N-substituted, preferably at an N atom different from the N atom attached to the ring system shown in formula (I)) by —CON(CH3)2.

[0429] Thus, in certain embodiments of the invention, the compound of formula (Ibp) has the formula (Ibt):

[0430] [ka]

[0431] is a compound of

[0432] W, R1, R2, R3, R4, X4, and X5 in compounds of formula (Ibt) are as defined above for compounds of formula (I).

[0433] Further, therefore, in certain embodiments of the present invention, the compound of formula (Ibq) has the formula (Ibu):

[0434] [ka]

[0435] is a compound of

[0436] R1, R2, R3, R4, X4, and X5 in the compounds of formula (Ibu) are as defined above for the compounds of formula (I).

[0437] Further, therefore, in certain embodiments of the present invention, the compound of formula (Ibr) has the formula (Ibv):

[0438] [ka]

[0439] is a compound of

[0440] R1, R4, X4, and X5 in the compounds of formula (Ibv) are as defined above for the compounds of formula (I).

[0441] Further, therefore, in certain embodiments of the present invention, the compound of formula (Ibs) has the formula (Ibw):

[0442] [ka]

[0443] is a compound of

[0444] R4, X4, and X5 in the compounds of formula (Ibt) are as defined above for the compounds of formula (I).

[0445] However, it should be noted that compounds of formula (Ibt), (Ibu) or (Ibv) wherein R1 is methyl or fluoromethyl are also included within the scope of the present invention.

[0446] In certain preferred embodiments, X4 is CR C4 and X5 is CR C5 Thus, in certain embodiments, compounds of formula (I) have the formula (Ibx):

[0447] [ka]

[0448] is a compound of

[0449] W, R1, R2, R3, R4, R in the compound of formula (Ibx) C4 , R C5 , X1, X2, and X3 are as defined above for compounds of formula (I).

[0450] Further, therefore, preferably W is -NHS(O) 2- Thus, in certain preferred embodiments of the present invention, the compounds of formula (Ibx) of the present invention have the formula (Iby):

[0451] [ka]

[0452] is a compound of

[0453] R1, R2, R3, R4, R in the compound of formula (Iby) C4 , R C5 , X1, X2, and X3 are as defined above for compounds of formula (I).

[0454] Furthermore, therefore, preferably, R2 and R3 together with the carbon atom to which they are attached form a cyclopropyl, so that in certain preferred embodiments of the present invention, the compound of formula (Iby) of the present invention has the formula (Ibz):

[0455] [ka]

[0456] is a compound of

[0457] R1, R4, R in the compound of formula (Ibz) C4 , R C5 , X1, X2, and X3 are as defined above for compounds of formula (I).

[0458] Furthermore, therefore, preferably R1 is cyano, so in a particular preferred embodiment of the present invention, the compound of formula (Ibz) of the present invention has the formula (Ica):

[0459] [ka]

[0460] is a compound of

[0461] R4, R in the compound of formula (Ica) C4 , R C5 , X1, X2, and X3 are as defined above for compounds of formula (I).

[0462] However, it should be noted that compounds of formula (Ibx), (Iby) or (Ibz) in which R1 is methyl or fluoromethyl are also included within the scope of the present invention.

[0463] In certain preferred embodiments, X1 is CH and X3 is CH.

[0464] Thus, in certain embodiments of the invention, the compound of formula (Ibx) has the formula (Icb):

[0465] [ka]

[0466] is a compound of

[0467] W, R1, R2, R3, R4, R in the compound of formula (Icb) C4 , R C5 and X2 are as defined above for compounds of formula (I).

[0468] Further, therefore, in certain embodiments of the present invention, the compound of formula (Iby) has the formula (Icc):

[0469] [ka]

[0470] is a compound of

[0471] R1, R2, R3, R4, R in the compound of formula (Icc) C4 , R C5 and X2 are as defined above for compounds of formula (I).

[0472] Further, therefore, in certain embodiments of the present invention, the compound of formula (Ibz) has the formula (Icd):

[0473] [ka]

[0474] is a compound of

[0475] R1, R4, R in the compound of formula (Icd) C4 , R C5 and X2 are as defined above for compounds of formula (I).

[0476] Further, therefore, in certain embodiments of the present invention, the compound of formula (Ica) has the formula (Ice):

[0477] [ka]

[0478] is a compound of

[0479] R4, R in the compound of formula (Ice) C4 , R C5 and X2 are as defined above for compounds of formula (I).

[0480] In certain preferred embodiments, X4 is CH and X5 is CH.

[0481] Thus, in certain embodiments of the present invention, the compound of formula (Icb) has the formula (Icf):

[0482] [ka]

[0483] is a compound of

[0484] W, R1, R2, R3, R4, and X2 in compounds of formula (Icf) are as defined above for compounds of formula (I).

[0485] Further, therefore, in certain embodiments of the present invention, the compound of formula (Icc) has the formula (Icg):

[0486] [ka]

[0487] is a compound of

[0488] R1, R2, R3, R4, and X2 in the compounds of formula (Icg) are as defined above for the compounds of formula (I).

[0489] Further, therefore, in certain embodiments of the present invention, the compound of formula (Icd) has the formula (Ich):

[0490] [ka]

[0491] is a compound of

[0492] R1, R4, and X2 in the compounds of formula (Ich) are as defined above for the compounds of formula (I).

[0493] Further, therefore, in certain embodiments of the present invention, the compound of formula (Icd) has the formula (Ici):

[0494] [ka]

[0495] is a compound of

[0496] R4 and X2 in compounds of formula (Ici) are as defined above for compounds of formula (I).

[0497] Preferred compounds of formula (I) are the following compounds:

[0498] [ka]

[0499] It is selected from its enantiomers, diastereomers, tautomers, pharmaceutically acceptable solvates, pharmaceutically acceptable crystalline forms, pharmaceutically acceptable salts or prodrugs thereof.

[0500] Further preferred compounds of formula (I) are

[0501] [ka]

[0502] or an enantiomer, diastereomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystalline form, pharmaceutically acceptable salt, or a prodrug thereof.

[0503] Further preferred compounds of formula (I) are:

[0504] [ka]

[0505] is selected from.

[0506] Further preferred compounds of formula (I) are:

[0507] [ka]

[0508] is selected from.

[0509] Further preferred compounds of formula (I) are:

[0510] [ka]

[0511] is selected from.

[0512] Further preferred compounds of formula (I) are:

[0513] [ka]

[0514] is selected from.

[0515] Further preferred compounds of formula (I) are

[0516] [ka]

[0517] and preferably

[0518] [ka]

[0519] Particularly preferred are the exemplified compounds described below, namely compounds 1 to 299. Preferably, the compound of formula (I) is

[0520] [ka]

[0521] [ka]

[0522] [ka]

[0523] or a pharmaceutically acceptable salt, hydrate or solvate thereof.

[0524] The present invention also relates to each of the intermediates further described below in the Examples section of this specification, including any one of these intermediates in non-salt form or in the form of a salt (e.g., a pharmaceutically acceptable salt) of the respective compound. Such intermediates can be used, inter alia, in the synthesis of compounds of formula (I).

[0525] The scope of the present invention includes all pharmaceutically acceptable salt forms of compounds of formula (I), which may be formed, for example, by protonation of an atom having a lone pair of electrons susceptible to protonation, such as an amino group, with an inorganic or organic acid, or as a salt of an acid group (such as a carboxylic acid group) with a physiologically acceptable cation. Exemplary base addition salts include alkali metal salts such as, for example, sodium or potassium salts; alkaline earth metal salts, for example, calcium or magnesium salts; zinc salts; ammonium salts; aliphatic amine salts such as trimethylamine, triethylamine, dicyclohexylamine, ethanolamine, diethanolamine, triethanolamine, procaine salts, meglumine salts, ethylenediamine salts, choline salts, and the like; aralkylamine salts such as N,N-dibenzylethylenediamine salts, benzathine salts, benethamine salts, and the like; heterocyclic aromatic amine salts such as pyridine salts, picoline salts, quinoline salts, isoquinoline salts, and the like; quaternary ammonium salts such as tetramethylammonium salts, tetraethylammonium salts, benzyltrimethylammonium salts, benzyltriethylammonium salts, benzyltributylammonium salts, methyltrioctylammonium salts, tetrabutylammonium salts, and the like; and basic amino acid salts, for example, arginine salts, lysine salts, or histidine salts. Exemplary acid addition salts include, for example, mineral acid salts such as hydrochloride, hydrobromide, hydroiodide, sulfate (such as sulfate or hydrogen sulfate), nitrate, phosphate (such as phosphate, hydrogen phosphate, or dihydrogen phosphate), carbonate, bicarbonate, perchlorate, borate, or thiocyanate.Acetate, propionate, butyrate, pentanoate, hexanoate, heptanoate, octanoate, cyclopentanepropionate, decanoate, undecanoate, oleate, stearate, lactate, maleate, oxalate, fumarate, tartrate, malate, citrate, succinate, adipate, gluconate, glycolate, nicotinate, benzoate, salicylate, ascorbate, pamoate (embonate), camphorate, glucohepta Organic acid salts such as phosphates and pivalates; sulfonates such as methanesulfonate (mesylate), ethanesulfonate (esylate), 2-hydroxyethanesulfonate (isethionate), benzenesulfonate (besylate), p-toluenesulfonate (tosylate), 2-naphthalenesulfonate (naphsylate), 3-phenylsulfonate, and camphorsulfonate; glycerophosphate; and acidic amino acid salts such as aspartate or glutamate. Preferred pharmaceutically acceptable salts of the compound of formula (I) include hydrochloride, hydrobromide, mesylate, sulfate, tartrate, fumarate, acetate, citrate, and phosphate. A particularly preferred pharmaceutically acceptable salt of the compound of formula (I) is hydrochloride. Thus, it is preferred that the compound of formula (I), including any one of the specific compounds of formula (I) described herein, is in the form of a hydrochloride, hydrobromide, mesylate, sulfate, tartrate, fumarate, acetate, citrate, or phosphate salt, and it is particularly preferred that the compound of formula (I) is in the form of a hydrochloride salt.

[0526] The present invention also specifically relates to compounds of formula (I), including any one of the specific compounds of formula (I) described herein in non-salt form.

[0527] Furthermore, the scope of the present invention includes the compounds of formula (I) in any solvated form, including, for example, solvates with water (i.e., as hydrates) or solvates with organic solvents such as methanol, ethanol, isopropanol, acetic acid, ethyl acetate, ethanolamine, DMSO, or acetonitrile. All physical forms of the compounds of formula (I), including any amorphous or crystalline forms (i.e., polymorphs), are also included within the scope of the present invention. It is to be understood that such solvates and physical forms of pharmaceutically acceptable salts of the compounds of formula (I) are also encompassed by the present invention.

[0528] Furthermore, compounds of formula (I) may exist in different isomeric, particularly stereoisomers (including, for example, geometric isomers (or cis / trans isomers), enantiomers and diastereomers) or tautomers (including, in particular, prototropic tautomers such as keto / enol tautomers or thione / thiol tautomers). All such isomers of compounds of formula (I) are considered to be part of the present invention, either in admixture or in pure or substantially pure form. With respect to stereoisomers, the present invention encompasses isolated optical isomers of compounds according to the present invention, as well as any mixtures thereof (including, in particular, racemic mixtures / racemates). Racemates can be resolved by physical methods, such as fractional crystallization, separation or crystallization of diastereomeric derivatives, or separation by chiral column chromatography. Individual optical isomers can also be obtained from racemates by salt formation with an optically active acid followed by crystallization. The present invention further encompasses any tautomers of compounds of formula (I). It will be understood that some compounds may exhibit tautomerism. In such cases, the formulas provided herein explicitly represent only one of the possible tautomeric forms. The formulas and chemical names provided herein are intended to encompass any tautomeric form of the corresponding compounds, and are not limited to only the specific tautomeric form shown by the drawings or identified by the compound name.

[0529] The scope of the present invention also includes compounds of formula (I) in which one or more atoms have been replaced with a specific isotope of the corresponding atom. For example, the present invention includes compounds of formula (I) in which one or more hydrogen atoms (or, for example, all hydrogen atoms) have been replaced with a deuterium atom (i.e., 2 H; also referred to as "D"). Thus, the present invention also encompasses compounds of formula (I) that are enriched with deuterium. Naturally occurring hydrogen is approximately 99.98 mole % hydrogen-1 ( 1 H) and about 0.0156 mole % deuterium ( 2 The deuterium content at one or more hydrogen positions in a compound of formula (I) can be increased using deuteration techniques known in the art. For example, a compound of formula (I) or a reactant or precursor used in the synthesis of a compound of formula (I) can be subjected to an H / D exchange reaction using, for example, heavy water (DO). Further suitable deuteration techniques are described in: Atzrodt J et al., Bioorg Med Chem, 20(18), 5658-5667, 2012; William JS et al., Journal of Labeled Compounds and Radiopharmaceuticals, 53(11-12), 635-644, 2010; Modvig A et al., J Org Chem, 79, 5861-5868, 2014. The deuterium content can be determined, for example, using mass spectrometry or NMR spectroscopy. Unless otherwise specified, it is preferred that the compounds of formula (I) are not deuterium enriched. Thus, the hydrogen atoms or 1 Preferably, H hydrogen atoms are present.

[0530] The present invention also provides a method for preparing a compound in which one or more atoms are positron-emitting isotopes of the corresponding atom, e.g. 18 F, 11 C. 13 N, 15 O. 76 Br, 77 Br, 120 I and / or 124Such compounds can be used as tracers, trackers or imaging probes in positron emission tomography (PET). Accordingly, the present invention provides compounds of formula (I) in which (i) one or more fluorine atoms (or, for example, all fluorine atoms) are replaced by fluorine atoms, such as fluorine atoms. 18 (ii) a compound of formula (I) in which one or more carbon atoms (or, for example, all carbon atoms) are replaced with a F atom; 11 (iii) compounds of formula (I) in which one or more nitrogen atoms (or, for example, all nitrogen atoms) are replaced by a C atom; 13 (iv) compounds of formula (I) in which one or more oxygen atoms (or, for example, all oxygen atoms) are replaced by N atoms; 15 (v) one or more bromine atoms (or, for example, all bromine atoms) are replaced by an O atom; 76 (vi) compounds of formula (I) in which one or more bromine atoms (or, for example, all bromine atoms) are replaced by Br atoms; 77 (vii) compounds of formula (I) in which one or more iodine atoms (or, for example, all iodine atoms) are replaced by Br atoms; 120 and (viii) compounds of formula (I) in which one or more iodine atoms (or, for example, all iodine atoms) are replaced by iodine atoms. 124 This includes compounds of formula (I) in which any atom in the compound of formula (I) is replaced by a specific isotope. In general, it is preferred that none of the atoms in the compound of formula (I) is replaced by a specific isotope.

[0531] The present invention further encompasses prodrugs of the compound of formula (I). As preferably understood herein, the term "prodrug" of the compound of formula (I) refers to a derivative of the compound of formula (I) that is metabolized to the compound of formula (I) upon administration to a subject. The prodrug of the compound of formula (I) may include modifications of the -OH, -NH2, or -COOH group, when present in the compound of formula (I), which can preferably be hydrolyzed to the -OH, -NH2, or -COOH group, respectively, for example, upon administration to a subject. For example, as known to those skilled in the art, such prodrugs preferably include modifications of the -OH moiety to -OR Xand R x preferably comprises a moiety selected from -CO-, -CH2-O-CO, -CH2-O-CO-O-, and -CH(CH3)-O-COO-, more preferably R x is -CO-R y , -CH2-O-CO-R y , -CH2-O-CO-OR y , and -CH(CH3)-O-COO-R y Selected from R y is preferably carbocyclyl, heterocyclyl, C 1~5 Alkyl, -NH-(C 1~5 alkyl) or -S-(C 1~5 alkyl), wherein alkyl is optionally halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C 1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 alkyl), and carbocyclyl and heterocyclyl are each optionally substituted by a group selected from halogen, —CN, —OH, C 1~5 Alkyl, C 1~5 Haloalkyl, -O(C 1~5 alkyl), -O(C 1~5 haloalkyl), -SH, -S(C 1~5 alkyl), -S(C 1~5 haloalkyl), -NH2, -NH(C 1~5 alkyl), -NH(C 1~5 haloalkyl), -N(C1~5 Alkyl)(C 1~5 alkyl), -N(C 1~5 haloalkyl)(C 1~5 alkyl), -CONH2, -CONH(C 1~5 alkyl), and -CON(C 1~5 Alkyl)(C 1~5 Further, for example, as known to those skilled in the art, such prodrugs preferably include those compounds of formula (I) that contain an -NH moiety derivative, where the -NH moiety is -NHCOO-R y and derivatives thereof, wherein R y is as defined above. Further, for example, as known to those skilled in the art, such prodrugs preferably include those compounds of formula (I) that contain a -COOH moiety, where the -COOH group is replaced by -COOR. y and derivatives thereof, wherein R y is as defined above. Further examples of groups that can be derivatized to give prodrugs will be known to those skilled in the art.

[0532] Pharmaceutical Composition The compounds provided herein may be administered as the compound per se or may be formulated as a medicament. The medicament / pharmaceutical composition may optionally include one or more pharmaceutically acceptable excipients such as carriers, diluents, fillers, disintegrants, lubricants, binders, colorants, pigments, stabilizers, preservatives, antioxidants, and / or solubility enhancers.

[0533] The pharmaceutical compositions may contain one or more solubility enhancers, for example, poly(ethylene glycol)s (e.g., PEG200, PEG300, PEG400, or PEG600) including poly(ethylene glycols) having a molecular weight ranging from about 200 to about 5,000 Da, ethylene glycol, propylene glycol, glycerol, nonionic surfactants, tyloxapol, polysorbate 80, macrogol-15-hydroxystearate (e.g., Kolliphor® HS15, CAS 70142-34-6), phospholipids, lecithin, dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine, distearoylphosphatidylcholine, cyclodextrin, α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, hydroxyethyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin, hydroxyethyl-γ-cyclodextrin, cyclodextrin, hydroxypropyl-γ-cyclodextrin, dihydroxypropyl-β-cyclodextrin, sulfobutylether-β-cyclodextrin, sulfobutylether-γ-cyclodextrin, glucosyl-α-dextrin, glucosyl-β-cyclodextrin, diglucosyl-β-cyclodextrin, maltosyl-α-cyclodextrin, maltosyl-β-cyclodextrin, maltosyl-γ-cyclodextrin, maltotriosyl-β-cyclodextrin, maltotriosyl-γ-cyclodextrin, dimaltosyl-β-cyclodextrin, methyl-β-cyclodextrin, carboxyalkyl thioether, hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinylpyrrolidone, sodium lauryl sulfate, sodium dioctyl sulfosuccinate, or any combination thereof.

[0534] The pharmaceutical compositions may also include one or more preservatives, particularly one or more antimicrobial preservatives, such as benzyl alcohol, chlorobutanol, 2-ethoxyethanol, m-cresol, chlorocresol (e.g., 2-chloro-3-methyl-ph...

Claims

1. Compounds of formula (I): 【Chemical 1】 or an enantiomer, diastereomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystalline form, pharmaceutically acceptable salt, or prodrug thereof, R １ is chloro, fluoro, cyano, formyl, (C １～２ ) alkyl, (C ２ ) alkenyl, (C ２ ) alkynyl, (C １～２ ) haloalkyl, -(C １～２ alkylene)-OH and -(C １～２ alkylene)-O-(C １～２ alkyl); R ２ and R ３ are independently, each (C １～２ ) alkyl or (C １～２ ) haloalkyl, or R ２ and R ３ together with the carbon atom to which they are attached form cyclopropyl; W is -NHS(O) ｙ－ , -S(O) ｙ NH-, -NHS(O)(NH)-, -NHS(O)(NCH ３ )-, -S(O)(NH)-NH-, -S(O)(NCH ３ )-NH-, where y is 1 or 2; X １ and X ３ are independently N, CH, C(C １～２ alkyl), C—Cl, and C—F; X ２ is N or C-Y ｃ２ -R ｃ２ and Y ｃ２ is a covalent bond, C １～５ Alkylene, C ２～５ Alkenylene, C ２～５ alkynylene, cycloalkylene, cycloalkenylene, heterocycloalkylene, and heterocycloalkenylene, wherein said alkylene, said alkenylene, and said alkynylene are each optionally selected from halogen, CN, OH, O(C １～５ alkyl), —O(C １～５ haloalkyl), C １～５ Haloalkyl, SH, S(C １５ alkyl), -S(C １～５ haloalkyl), NH ２ , NH(C １～５ alkyl), -NH(C １～５ haloalkyl), N(C １～５ alkyl) (C １～５ alkyl), N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), CONH ２ , CONH(C １～５ alkyl), CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), NHCO—(C １～５ alkyl), N(C １～５ alkyl)-CO-(C １～５ alkyl), NHCONH ２ , NHCONH-(C １～５ alkyl), NHCON(C １～５ alkyl) (C １～５ alkyl), N(C １～５ alkyl)CONH ２ , N(C １～５ alkyl)CONH-(C １～５ alkyl), and N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ substituted by one or more groups independently selected from halogen, CN, OH, O(C １～５ alkyl), SH, S(C １５ alkyl), NH ２ , NH(C １～５ alkyl), and N(C １～５ alkyl) (C １～５ alkyl), and further, one or more of -CH contained in said alkylene, said alkenylene or said alkynylene ２ -units are each optionally -O-, NH-, N(C １～５ alkyl)-, CO-, S-, -SO-, and SO ２ -, and further, the cycloalkylene, the cycloalkenylene, the heterocycloalkylene, and the heterocycloalkenylene are each optionally substituted with halogen, CN, OH, C １～５ Alkyl, C １～５ Haloalkyl, O(C １～５ alkyl), —O(C １～５ haloalkyl), SH, S(C １５ alkyl), -S(C １～５ haloalkyl), NH ２ , NH(C １～５ alkyl), -NH(C １～５ haloalkyl), N(C １～５ alkyl) (C １～５ alkyl), N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), CONH ２ , CONH(C １～５ alkyl), CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), NHCO—(C １～５ alkyl), N(C １～５ alkyl)-CO-(C １～５ alkyl), NHCONH ２ , NHCONH-(C １～５ alkyl), NHCON(C １～５ alkyl) (C １～５ alkyl), N(C １～５ alkyl)CONH ２ , N(C １～５ alkyl)CONH-(C １～５ alkyl), and N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CN, -(C １～５ alkylene)OH, -(C １～５ alkylene)O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -(C １～５ alkylene)SH, -(C １～５ alkylene)S(C １５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -(C １～５ alkylene)NH ２ , -(C １～５ alkylene)NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)N(C １～５ alkyl) (C １～５ haloalkyl), -(C １～５ alkylene)(N-heterocycloalkyl), -(C １～５ alkylene)N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ alkyl), -(C １～５ alkylene)CONH ２ , -(C １～５ alkylene)CONH(C １～５ alkyl), -(C １～５ alkylene)CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)CO—(N-heterocycloalkyl), —(C １～５ alkylene)NHCO-(C １～５ alkyl), -(C １～５ alkylene)N(C １～５ alkyl)-CO-(C １～５ alkyl), -(C １～５ alkylene)NHCONH ２ , -(C １～５ alkylene)NHCONH-(C １～５ alkyl), -(C １～５ alkylene)NHCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)N(C １～５ alkyl)CONH ２ , -(C １～５ alkylene)N(C １～５ alkyl)CONH-(C １～５ alkyl), and -(C １～５ alkylene)N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), preferably halogen, CN, OH, C １～５ Alkyl, O(C １～５ alkyl), SH, S(C １５ alkyl), NH ２ , NH(C １～５ alkyl), and N(C １～５ alkyl) (C １～５ alkyl), R ｃ２ is hydrogen, halo, -OH, -NH ２ , -SH, -CN,C １～１２ Alkyl, C ２～１２ Alkenyl, C ２～１２ selected from alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl; The alkyl, the alkenyl, or the alkynyl may optionally be a halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), C １～５ Haloalkyl, —SH, —S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), —NHCO—(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), -N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -S(O)(C １～５ alkyl), -S(O) ２ (C １～５ alkyl), -S(O)(NH)(C １～５ alkyl), -S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -N=S(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), and -P(O)(O(C １～５ alkyl)) (C １～５ and is substituted by one or more groups independently selected from halogen, —CN, —OH, —O(C １～５ alkyl)-, -O(C １～５ haloalkyl)-, C １～５ Haloalkyl, —SH, —S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), preferably halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), C １～５ Haloalkyl, —SH, —S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), -N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -S(O)(C １～５ alkyl), -S(O) ２ (C １～５ alkyl), -S(O)(NH)(C １～５ alkyl), -S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -N=S(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), and -P(O)(O(C １～５ alkyl)) (C １～５ alkyl), preferably halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), C １～５ Haloalkyl, —SH, —S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), The cycloalkyl, the cycloalkenyl, the heterocycloalkyl, the heterocycloalkenyl, the aryl or the heteroaryl may optionally be selected from the group consisting of halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(O)(C １～５ alkyl), -S(O) ２ (C １～５ alkyl), -S(O)(NH)(C １～５ alkyl), -S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -N=S(O)(C １～５ alkyl) (C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CO(C １～５ haloalkyl), —CO-cycloalkyl, —COO(C １～５ alkyl), -COO(C １～５ haloalkyl), -COO-cycloalkyl, -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), -N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -OCONH ２ , -OCONH-(C １～５ alkyl), -OCON(C １～５ alkyl) (C １～５ alkyl), -NHCOO(C １～５ alkyl), -N(C １～５ alkyl)COO-(C １～５ alkyl), -P(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-CN, -(C １～５ alkylene)-OH, -(C １～５ alkylene)-O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -(C １～５ alkylene)-SH, -(C １～５ alkylene)-S(C １～５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -(C １～５ alkylene)-S(O)(C １～５ alkyl), -(C １～５ alkylene)-S(O) ２ (C １～５ alkyl), -(C １～５ alkylene)-S(O)(NH)(C １～５ alkyl), -(C １～５ alkylene)-S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ (alkylene)-NH ２ , -(C １～５ alkylene)-NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ haloalkyl), -(C １～５ alkylene)-(N-heterocycloalkyl), -(C １～５ alkylene)-N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ haloalkyl), -(C １～５ alkylene)-CO-cycloalkyl, -(C １～５ (alkylene)-CONH ２ , -(C １～５ alkylene)-CONH(C １～５ alkyl), -(C １～５ alkylene)-CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO-(N-heterocycloalkyl), -(C １～５ alkylene)-NHCO-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)-CO-(C １～５ alkyl), -(C １～５ (alkylene)-NHCONH ２ , -(C １～５ alkylene)-NHCONH-(C １～５ alkyl), -(C １～５ alkylene)-NHCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CONH ２ , -(C １～５ alkylene)-N(C １～５ alkyl)CONH-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ (alkylene)-OCONH ２ , -(C １～５ alkylene)-OCONH-(C １～５ alkyl), -(C １～５ alkylene)-OCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-NHCOO(C １～５ alkyl), and -(C １～５ alkylene)-N(C １～５ alkyl)COO-(C １～５ substituted with one or more groups independently selected from Preferably, halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(O)(C １～５ alkyl), -S(O) ２ (C １～５ alkyl), -S(O)(NH)(C １～５ alkyl), -S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -N=S(O)(C １～５ alkyl) (C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -COO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), -N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -OCONH ２ , -OCONH-(C １～５ alkyl), -OCON(C １～５ alkyl) (C １～５ alkyl), -NH COO (C １～５ alkyl), -N(C １～５ alkyl)COO-(C １～５ alkyl), -P(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-CN, -(C １～５ alkylene)-OH, -(C １～５ alkylene)-O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -(C １～５ alkylene)-SH, -(C １～５ alkylene)-S(C １～５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -(C １～５ alkylene)-S(O)(C １～５ alkyl), -(C １～５ alkylene)-S(O) ２ (C １～５ alkyl), -(C １～５ alkylene)-S(O)(NH)(C １～５ alkyl), -(C １～５ alkylene)-S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ (alkylene)-NH ２ , -(C １～５ alkylene)-NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ haloalkyl), -(C １～５ alkylene)-(N-heterocycloalkyl), -(C １～５ alkylene)-N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ alkyl), -(C １～５ (alkylene)-CONH ２ , -(C １～５ alkylene)-CONH(C １～５ alkyl), -(C １～５ alkylene)-CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO-(N-heterocycloalkyl), -(C １～５ alkylene)-NHCO-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)-CO-(C １～５ alkyl), -(C １～５ (alkylene)-NHCONH ２ , -(C １～５ alkylene)-NHCONH-(C １～５ alkyl), -(C １～５ alkylene)-NHCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CONH ２ , -(C １～５ alkylene)-N(C １～５ alkyl)CONH-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ (alkylene)-OCONH ２ , -(C １～５ alkylene)-OCONH-(C １～５ alkyl), -(C １～５ alkylene)-OCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-NHCOO(C １～５ alkyl), and -(C １～５ alkylene)-N(C １～５ alkyl)COO-(C １～５ alkyl), more preferably halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(O)(C １～５ alkyl), -S(O) ２ (C １～５ alkyl), -S(O)(NH)(C １～５ alkyl), -S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -N=S(O)(C １～５ alkyl) (C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), -N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -P(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-CN, -(C １～５ alkylene)-OH, -(C １～５ alkylene)-O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -(C １～５ alkylene)-SH, -(C １～５ alkylene)-S(C １～５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -(C １～５ alkylene)-S(O)(C １～５ alkyl), -(C １～５ alkylene)-S(O) ２ (C １～５ alkyl), -(C １～５ alkylene)-S(O)(NH)(C １～５ alkyl), -(C １～５ alkylene)-S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ (alkylene)-NH ２ , -(C １～５ alkylene)-NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ haloalkyl), -(C １～５ alkylene)-(N-heterocycloalkyl), -(C １～５ alkylene)-N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ alkyl), -(C １～５ (alkylene)-CONH ２ , -(C １～５ alkylene)-CONH(C １～５ alkyl), -(C １～５ alkylene)-CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO-(N-heterocycloalkyl), -(C １～５ alkylene)-NHCO-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)-CO-(C １～５ alkyl), -(C １～５ (alkylene)-NHCONH ２ , -(C １～５ alkylene)-NHCONH-(C １～５ alkyl), -(C １～５ alkylene)-NHCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CONH ２ , -(C １～５ alkylene)-N(C １～５ alkyl)CONH-(C １～５ alkyl), and -(C １～５ alkylene)-N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), more preferably halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -(C １～５ alkylene)-OH, -(C １～５ alkylene)-O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -(C １～５ alkylene)-SH, -(C １～５ alkylene)-S(C １～５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ (alkylene)-NH ２ , -(C １～５ alkylene)-NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), more preferably is halogen, -CN, -OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl); X ４ But N or C-R ｃ４ and R ｃ４ But hydrogen, halo, C １～６ Alkyl, C ２～６ Alkynyl, —O(C １～６ alkyl), -S(C １～６ alkyl), -NH(C １～６ alkyl), -N(C １～６ alkyl) (C １～６ alkyl), -CO(C １～６ alkyl), C １～６ haloalkyl, —O(C １～６ haloalkyl), -S(C １～６ haloalkyl), -NH(C １～６ haloalkyl), -N(C １～６ haloalkyl) ２ , -CO(C １～６ haloalkyl), -(C ０～３ alkylene)cycloalkyl, —O—(C ０～３ alkylene)-cycloalkyl, —CO—(C ０～３ alkylene)-cycloalkyl, -(C ０～３ alkylene)cycloalkenyl, —O—(C ０～３ alkylene)-cycloalkenyl, —CO—(C ０～３ alkylene)-cycloalkenyl, -(C ０～３ alkylene)-heterocycloalkyl, —O—(C ０～３ alkylene)-heterocycloalkyl, —CO—(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-heterocycloalkenyl, —O—(C ０～３ alkylene)-heterocycloalkenyl, —CO—(C ０～３ alkylene)-heterocycloalkenyl, -(C ０～３ alkylene)-aryl, —O—(C ０～３ alkylene)-aryl, —CO—(C ０～３ alkylene)-aryl, -(C ０～３ alkylene)-heteroaryl, —O—(C ０～３ alkylene)-heteroaryl and —CO—(C ０～３ alkylene)-heteroaryl; The alkyl or the alkynyl may optionally be selected from the group consisting of halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), C １～５ Haloalkyl, —SH, —S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), —NHCO—(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), and —N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ and is substituted by one or more groups independently selected from halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), The cycloalkyl, the cycloalkenyl, the heterocycloalkyl, the heterocycloalkenyl, the aryl or the heteroaryl may optionally be selected from the group consisting of halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), and —N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CN, -(C １～５ alkylene)-OH, -(C １～５ alkylene)-O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -(C １～５ alkylene)-SH, -(C １～５ alkylene)-S(C １～５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -(C １～５ (alkylene)-NH ２ , -(C １～５ alkylene)-NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ haloalkyl), -(C １～５ alkylene)-(N-heterocycloalkyl), -(C １～５ alkylene)-N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ alkyl), -(C １～５ (alkylene)-CONH ２ , -(C １～５ alkylene)-CONH(C １～５ alkyl), -(C １～５ alkylene)-CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO-(N-heterocycloalkyl), -(C １～５ alkylene)-NHCO-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)-CO-(C １～５ alkyl), -(C １～５ (alkylene)-NHCONH ２ , -(C １～５ alkylene)-NHCONH-(C １～５ alkyl), -(C １～５ alkylene)-NHCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CONH ２ , -(C １～５ alkylene)-N(C １～５ alkyl)CONH-(C １～５ alkyl), and -(C １～５ alkylene)-N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), preferably halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl); X ５ But N or C-R ｃｓ and R ｃ５ But hydrogen, halo, C １～６ Alkyl, —O(C １～６ alkyl), -S(C １～６ alkyl), -NH(C １～６ alkyl), -N(C １～６ alkyl) (C １～６ alkyl) and C １～６ haloalkyl; R ４ But Y Ｒ５ -R Ｒ５ and Y Ｒ５ is a covalent bond, C １～４ Alkylene, C ２～４ Alkenylene, and C ２～４ alkynylene, wherein said alkylene, said alkenylene, and said alkynylene are each optionally selected from halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -SO(C １～５ alkyl), -SO ２ (C １～５ alkyl), -S(C １～５ haloalkyl), —SO(C １～５ haloalkyl), -SO ２ (C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), and —N(C １～５ haloalkyl) (C １～５ and further, the alkylene, the alkenylene, or the alkynylene is substituted with one or more groups independently selected from -CH ２ -units are each optionally -O-, NH-, N(C １～５ alkyl)-, CO-, —COO-, S-, —SO-, and SO ２ -substituted by groups independently selected from R Ｒ５ But C １～１２ Alkyl, C １～１２ Alkenyl, C ２～１２ selected from alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl; The alkyl, the alkenyl, or the alkynyl may optionally be a halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ and wherein said cycloalkyl, said cycloalkenyl, said heterocycloalkyl, said heterocycloalkenyl, said aryl or said heteroaryl is optionally substituted with one or more groups independently selected from halogen, —CN, —OH, —C １～５ Alkyl, —C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -SO(C １～５ alkyl), -SO ２ (C １～５ alkyl), -S(C １～５ haloalkyl), —SO(C １～５ haloalkyl), —SO ２ (C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ and n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 39, 38, 3

2. R １ But cyano, (C １～２ ) alkyl, and (C １～２ 2. The compound of claim 1, wherein the aryl group is selected from the group consisting of aryl, ...

3. R １ The compound of claim 1 , wherein is selected from the group consisting of cyano, methyl, and fluoromethyl.

4. R １ The compound of claim 1 , wherein is cyano.

5. R １ The compound of claim 1 , wherein is methyl.

6. R １ The compound of claim 1 , wherein is fluoromethyl.

7. R ２ and R ３ and together with the carbon atom to which they are attached form a cyclopropyl.

8. W is -NHS(O) ２ -, and preferably the left side of W as defined herein is R １ , R ２ and R ３ and the right side of W, as defined herein, is attached to the ring system of formula (I).

9. X １ and X ３ is independently selected from the group consisting of N, CH, and CF.

10. X １ and X ３ and each is CH.

11. X 2 is C—Y C2 —R C2 , and Y ｃ２ is a covalent bond, C １～５ Alkylene, C ２～５ Alkenylene, C ２～５ alkynylene, cycloalkylene, and heterocycloalkylene, wherein said alkylene, said alkenylene, and said alkynylene are each optionally selected from halogen, CN, OH, O(C １～５ alkyl), —O(C １～５ haloalkyl), C １～５ Haloalkyl, SH, S(C １５ alkyl), -S(C １～５ haloalkyl), NH ２ , NH(C １～５ alkyl), -NH(C １～５ haloalkyl), N(C １～５ alkyl) (C １～５ alkyl), N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), CONH ２ , CONH(C １～５ alkyl), CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), NHCO—(C １～５ alkyl), N(C １～５ alkyl)-CO-(C １～５ alkyl), NHCONH ２ , NHCONH-(C １～５ alkyl), NHCON(C １～５ alkyl) (C １～５ alkyl), N(C １～５ alkyl)CONH ２ , N(C １～５ alkyl)CONH-(C １～５ alkyl), and N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), preferably halogen, CN, OH, O(C １～５ alkyl), SH, S(C １５ alkyl), NH ２ , NH(C １～５ alkyl), and N(C １～５ alkyl) (C １～５ alkyl), and further, one or more of -CH contained in said alkylene, said alkenylene or said alkynylene ２ -units are each optionally -O-, NH-, N(C １～５ alkyl)-, CO-, S-, -SO-, and SO ２ -, and wherein said cycloalkylene and said heterocycloalkylene are each optionally substituted with a group independently selected from halogen, CN, OH, C １～５ Alkyl, C １～５ Haloalkyl, O(C １～５ alkyl), —O(C １～５ haloalkyl), SH, S(C １５ alkyl), -S(C １～５ haloalkyl), NH ２ , NH(C １～５ alkyl), -NH(C １～５ haloalkyl), N(C １～５ alkyl) (C １～５ alkyl), N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), CONH ２ , CONH(C １～５ alkyl), CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), NHCO—(C １～５ alkyl), N(C １～５ alkyl)-CO-(C １～５ alkyl), NHCONH ２ , NHCONH-(C １～５ alkyl), NHCON(C １～５ alkyl) (C １～５ alkyl), N(C １～５ alkyl)CONH ２ , N(C １～５ alkyl)CONH-(C １～５ alkyl), and N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CN, -(C １～５ alkylene)OH, -(C １～５ alkylene)O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -(C １～５ alkylene)SH, -(C １～５ alkylene)S(C １５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -(C １～５ alkylene)NH ２ , -(C １～５ alkylene)NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)N(C １～５ alkyl) (C １～５ haloalkyl), -(C １～５ alkylene)(N-heterocycloalkyl), -(C １～５ alkylene)N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ alkyl), -(C １～５ alkylene)CONH ２ , -(C １～５ alkylene)CONH(C １～５ alkyl), -(C １～５ alkylene)CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)CO—(N-heterocycloalkyl), —(C １～５ alkylene)NHCO-(C １～５ alkyl), -(C １～５ alkylene)N(C １～５ alkyl)-CO-(C １～５ alkyl), -(C １～５ alkylene)NHCONH ２ , -(C １～５ alkylene)NHCONH-(C １～５ alkyl), -(C １～５ alkylene)NHCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)N(C １～５ alkyl)CONH ２ , -(C １～５ alkylene)N(C １～５ alkyl)CONH-(C １～５ alkyl), and -(C １～５ alkylene)N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), preferably halogen, CN, OH, C １～５ Alkyl, O(C １～５ alkyl), SH, S(C １５ alkyl), NH ２ , NH(C １～５ alkyl), and N(C １～５ alkyl) (C １～５ 2. The compound of claim 1, wherein the aryl group is selected from the group consisting of aryl, aryl(alkyl), ...

12. X ２ But C-Y ｃ２ -R ｃ２ and -Y ｃ２ -R ｃ２ But -O-C １～１２ Alkyl, —NH—C １～１２ Alkyl, —N(C １～５ alkyl)-C １～１２ Alkyl, —O—C ２～１２ Alkenyl, —NH—C ２～１２ Alkenyl, —N(C １～５ alkyl)-C ２～１２ Alkenyl, —O—C ２～１２ Alkynyl, —NH—C ２～１２ Alkynyl, —N(C １～５ alkyl)-C ２～１２ Alkynyl, (C ０～３ alkylene)-cycloalkyl, —CO—(C ０～３ alkylene)cycloalkyl, (C ０～３ alkylene)-CO-cycloalkyl, -CONH-(C ０～３ alkylene)cycloalkyl, -(C ０～３ alkylene)-CONH-cycloalkyl, -NHCO-(C ０～３ alkylene)cycloalkyl, (C ０～３ alkylene)-NHCO-cycloalkyl, —NH—(C ０～３ alkylene)cycloalkyl, -(C ０～３ alkylene)-NH-cycloalkyl, —O—(C ０～３ alkylene)cycloalkyl, -(C ０～３ alkylene)-O-cycloalkyl, —SO ２ -(C ０～３ alkylene)cycloalkyl, -(C ０～３ (alkylene)-SO ２ -cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, -SO ２ -cycloalkyl, (C ０～３ alkylene)-cycloalkenyl, —CO—(C ０～３ alkylene)cycloalkenyl, (C ０～３ alkylene)-CO-cycloalkenyl, -CONH-(C ０～３ alkylene)cycloalkenyl, -(C ０～３ alkylene)-CONH-cycloalkenyl, -NHCO-(C ０～３ alkylene)cycloalkenyl, (C ０～３ alkylene)-NHCO-cycloalkenyl, -NH-(C ０～３ alkylene)cycloalkenyl, -(C ０～３ alkylene)-NH-cycloalkenyl, —O—(C ０～３ alkylene)cycloalkenyl, -(C ０～３ alkylene)-O-cycloalkenyl, —SO ２ -(C ０～３ alkylene)cycloalkenyl, -(C ０～３ (alkylene)-SO ２ -cycloalkenyl, -CONH-cycloalkenyl, -NHCO-cycloalkenyl, -NH-cycloalkenyl, -O-cycloalkenyl, -CO-cycloalkenyl, -SO ２ -cycloalkenyl, -(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-CO-heterocycloalkyl, -CONH-(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-CONH-heterocycloalkyl, -NHCO-(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-NHCO-heterocycloalkyl, —NH—(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-NH-heterocycloalkyl, —O—(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-O-heterocycloalkyl, —SO ２ -(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ (alkylene)-SO ２ -heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO ２ -heterocycloalkyl, -(C ０～３ alkylene)-heterocycloalkenyl, —CO—(C ０～３ alkylene)heterocycloalkenyl, -(C ０～３ alkylene)-CO-heterocycloalkenyl, -CONH-(C ０～３ alkylene)heterocycloalkenyl, -(C ０～３ alkylene)-CONH-heterocycloalkenyl, -NHCO-(C ０～３ alkylene)heterocycloalkenyl, -(C ０～３ alkylene)-NHCO-heterocycloalkenyl, -NH-(C ０～３ alkylene)heterocycloalkenyl, -(C ０～３ alkylene)-NH-heterocycloalkenyl, —O—(C ０～３ alkylene)heterocycloalkenyl, -(C ０～３ alkylene)-O-heterocycloalkenyl, —SO ２ -(C ０～３ alkylene)heterocycloalkenyl, -(C ０～３ (alkylene)-SO ２ -heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, -CO-heterocycloalkenyl, -SO ２ heterocycloalkenyl, (C ０～３ alkylene)aryl, —CO—(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-CO-aryl, -CONH-(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-CONH-aryl, -NHCO-(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-NHCO-aryl, -NH-(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-NH-aryl, —O—(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-O-aryl, —SO ２ -(C ０～３ alkylene)aryl, -(C ０～３ (alkylene)-SO ２ -aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO ２ -aryl, -(C ０～３ alkylene)heteroaryl, —CO—(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-CO-heteroaryl, -CONH-(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-CONH-heteroaryl, -NHCO-(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-NHCO-heteroaryl, —NH—(C ０～３ alkylene)heteroaryl, (C ０～３ alkylene)-NH-heteroaryl, —O—(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-O-heteroaryl, —SO ２ -(C ０～３ alkylene)heteroaryl, -(C ０～３ (alkylene)-SO ２ -heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO ２ -heteroaryl, preferably -Y ｃ２ -R ｃ２ But -O-C １～１２ Alkyl, —NH—C １～１２ Alkyl, —N(C １～５ alkyl)-C １～１２ Alkyl, —O—C ２～１２ Alkenyl, —NH—C ２～１２ Alkenyl, —N(C １～５ alkyl)-C ２～１２ Alkenyl, —O—C ２～１２ Alkynyl, —NH—C ２～１２ Alkynyl, —N(C １～５ alkyl)-C ２～１２ Alkynyl, (C ０～３ alkylene)-cycloalkyl, —CO—(C ０～３ alkylene)cycloalkyl, (C ０～３ alkylene)-CO-cycloalkyl, -CONH-(C ０～３ alkylene)cycloalkyl, -(C ０～３ alkylene)-CONH-cycloalkyl, -NHCO-(C ０～３ alkylene)cycloalkyl, (C ０～３ alkylene)-NHCO-cycloalkyl, —NH—(C ０～３ alkylene)cycloalkyl, -(C ０～３ alkylene)-NH-cycloalkyl, —O—(C ０～３ alkylene)cycloalkyl, -(C ０～３ alkylene)-O-cycloalkyl, —SO ２ -(C ０～３ alkylene)cycloalkyl, -(C ０～３ (alkylene)-SO ２ -cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, -SO ２ -cycloalkyl, -(C ０～３ alkylene)-heterocycloalkyl, —CO—(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-CO-heterocycloalkyl, -CONH-(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-CONH-heterocycloalkyl, -NHCO-(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-NHCO-heterocycloalkyl, —NH—(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-NH-heterocycloalkyl, —O—(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-O-cycloalkyl, —SO ２ -(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ (alkylene)-SO ２ -heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO ２ heterocycloalkyl, (C ０～３ alkylene)aryl, —CO—(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-CO-aryl, -CONH-(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-CONH-aryl, -NHCO-(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-NHCO-aryl, -NH-(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-NH-aryl, —O—(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-O-aryl, —SO ２ -(C ０～３ alkylene)aryl, -(C ０～３ (alkylene)-SO ２ -aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO2-aryl, -(C ０～３ alkylene)heteroaryl, —CO—(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-CO-heteroaryl, -CONH-(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-CONH-heteroaryl, -NHCO-(C ０～３ alkylene)heteroaryl, -(C ０～３ (alkylene)-NHCO -heteroaryl, -NH-(C ０～３ alkylene)heteroaryl, (C ０～３ alkylene)-NH-heteroaryl, —O—(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-O-heteroaryl, —SO ２ -(C ０～３ alkylene)heteroaryl, -(C ０～３ (alkylene)-SO ２ -heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO ２ -heteroaryl, wherein said alkyl, said alkenyl, or said alkynyl is optionally selected from halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), C １～５ Haloalkyl, —SH, —S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), —NHCO—(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), -N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -S(O)(C １～５ alkyl), -S(O) ２ (C １～５ alkyl), -S(O)(NH)(C １～５ alkyl), -S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -N=S(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), and -P(O)(O(C １～５ alkyl)) (C １～５ and is substituted by one or more groups independently selected from halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -C １～５ Haloalkyl, —SH, —S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), wherein said cycloalkyl, said cycloalkenyl, said heterocycloalkyl, said heterocycloalkenyl, said aryl or said heteroaryl is optionally selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(O)(C １～５ alkyl), -S(O) ２ (C １～５ alkyl), -S(O)(NH)(C １～５ alkyl), -S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -N=S(O)(C １～５ alkyl) (C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CO(C １～５ haloalkyl), —CO-cycloalkyl, —COO(C １～５ alkyl), -COO(C １～５ haloalkyl), -COO-cycloalkyl, -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), —NHCO—(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), -N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -OCONH ２ , -OCONH-(C １～５ alkyl), -OCON(C １～５ alkyl) (C １～５ alkyl), -NHCOO(C １～５ alkyl), -N(C １～５ alkyl)COO-(C １～５ alkyl), -P(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-CN, -(C １～５ alkylene)-OH, -(C １～５ alkylene)-O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -(C １～５ alkylene)-SH, -(C １～５ alkylene)-S(C １～５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -(C １～５ alkylene)-S(O)(C １～５ alkyl), -(C １～５ alkylene)-S(O) ２ (C １～５ alkyl), -(C １～５ alkylene)-S(O)(NH)(C １～５ alkyl), -(C １～５ alkylene)-S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ (alkylene)-NH ２ , -(C １～５ alkylene)-NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ haloalkyl), -(C １～５ alkylene)-(N-heterocycloalkyl), -(C １～５ alkylene)-N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ haloalkyl), -(C １～５ alkylene)-CO-cycloalkyl, -(C １～５ (alkylene)-CONH ２ , -(C １～５ alkylene)-CONH(C １～５ alkyl), -(C １～５ alkylene)-CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO-(N-heterocycloalkyl), -(C １～５ alkylene)-NHCO-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)-CO-(C １～５ alkyl), -(C １～５ (alkylene)-NHCONH ２ , -(C １～５ alkylene)-NHCONH-(C １～５ alkyl), -(C １～５ alkylene)-NHCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CONH ２ , -(C １～５ alkylene)-N(C １～５ alkyl)CONH-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ (alkylene)-OCONH ２ , -(C １～５ alkylene)-OCONH-(C １～５ alkyl), -(C １～５ alkylene)-OCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-NHCOO(C １～５ alkyl), and -(C １～５ alkylene)-N(C １～５ alkyl)COO-(C １～５ 10. The compound of claim 1, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

13. -Y ｃ２ -R ｃ２ But -(C ０～３ alkylene)-heterocycloalkyl, —CO—(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-CO-heterocycloalkyl, -CONH-(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-CONH-heterocycloalkyl, -NHCO-(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-NHCO-heterocycloalkyl, —NH—(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-NH-heterocycloalkyl, —O—(C ０～３ alkylene)heterocycloalkyl, (C ０～３ alkylene)-O-cycloalkyl, (C ０～３ alkylene)-O-heterocycloalkyl, —SO ２ -(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ (alkylene)-SO ２ -heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO ２ -heterocycloalkyl, -(C ０～３ alkylene)-heterocycloalkenyl, —CO—(C ０～３ alkylene)heterocycloalkenyl, -(C ０～３ alkylene)-CO-heterocycloalkenyl, -CONH-(C ０～３ alkylene)heterocycloalkenyl, -(C ０～３ alkylene)-CONH-heterocycloalkenyl, -NHCO-(C ０～３ alkylene)heterocycloalkenyl, -(C ０～３ alkylene)-NHCO-heterocycloalkenyl, -NH-(C ０～３ alkylene)heterocycloalkenyl, -(C ０～３ alkylene)-NH-heterocycloalkenyl, —O—(C ０～３ alkylene)heterocycloalkenyl, (C ０～３ alkylene)-O-heterocycloalkenyl, —SO ２ -(C ０～３ alkylene)heterocycloalkenyl, -(C ０～３ (alkylene)-SO ２ -heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, -CO-heterocycloalkenyl, -SO ２ -heterocycloalkenyl, -(C ０～３ alkylene)aryl, —CO—(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-CO-aryl, -CONH-(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-CONH-aryl, -NHCO-(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-NHCO-aryl, -NH-(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-NH-aryl, —O—(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-O-aryl, —SO ２ -(C ０～３ alkylene)aryl, -(C ０～３ (alkylene)-SO ２ -aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO ２ -aryl, -(C ０～３ alkylene)heteroaryl, —CO—(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-CO-heteroaryl, -CONH-(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-CONH-heteroaryl, -NHCO-(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-NHCO-heteroaryl, —NH—(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-NH-heteroaryl, —O—(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-O-heteroaryl, —SO ２ -(C ０～３ alkylene)heteroaryl, -(C ０～３ (alkylene)-SO ２ -heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO ２ -heteroaryl, preferably -Y ｃ２ -R ｃ２ But -(C ０～３ alkylene)-heterocycloalkyl, —CO—(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-CO-heterocycloalkyl, -CONH-(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-CONH-heterocycloalkyl, -NHCO-(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-NHCO-heterocycloalkyl, —NH—(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ alkylene)-NH-heterocycloalkyl, —O—(C ０～３ alkylene)heterocycloalkyl, (C ０～３ alkylene)-O-cycloalkyl, —SO ２ -(C ０～３ alkylene)heterocycloalkyl, -(C ０～３ (alkylene)-SO ２ -heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO ２ -heterocycloalkyl, -(C ０～３ alkylene)aryl, —CO—(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-CO-aryl, -CONH-(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-CONH-aryl, -NHCO-(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-NHCO-aryl, -NH-(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-NH-aryl, —O—(C ０～３ alkylene)aryl, -(C ０～３ alkylene)-O-aryl, —SO ２ -(C ０～３ alkylene)aryl, -(C ０～３ (alkylene)-SO ２ -aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO ２ -aryl, -(C ０～３ alkylene)heteroaryl, —CO—(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-CO-heteroaryl, -CONH-(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-CONH-heteroaryl, -NHCO-(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-NHCO-heteroaryl, —NH—(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-NH-heteroaryl, —O—(C ０～３ alkylene)heteroaryl, -(C ０～３ alkylene)-O-heteroaryl, —SO ２ -(C ０～３ alkylene)heteroaryl, -(C ０～３ (alkylene)-SO ２ -heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO ２ -heteroaryl, wherein said heterocycloalkyl, said heterocycloalkenyl, said aryl or said heteroaryl is optionally selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(O)(C １～５ alkyl), -S(O) ２ (C １～５ alkyl), -S(O)(NH)(C １～５ alkyl), -S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -N=S(O)(C １～５ alkyl) (C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CO(C １～５ haloalkyl), —CO-cycloalkyl, —COO(C １～５ alkyl), -COO(C １～５ haloalkyl), -COO-cycloalkyl, -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), —NHCO—(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), -N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -OCONH ２ , -OCONH-(C １～５ alkyl), -OCON(C １～５ alkyl) (C １～５ alkyl), -NHCOO(C １～５ alkyl), -N(C １～５ alkyl)COO-(C １～５ alkyl), -P(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-CN, -(C １～５ alkylene)-OH, -(C １～５ alkylene)-O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -(C １～５ alkylene)-SH, -(C １～５ alkylene)-S(C １～５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -(C １～５ alkylene)-S(O)(C １～５ alkyl), -(C １～５ alkylene)-S(O) ２ (C １～５ alkyl), -(C １～５ alkylene)-S(O)(NH)(C １～５ alkyl), -(C １～５ alkylene)-S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ Al Kiren)-P(O)(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ (alkylene)-NH ２ , -(C １～５ alkylene)-NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ haloalkyl), -(C １～５ alkylene)-(N-heterocycloalkyl), -(C １～５ alkylene)-N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ haloalkyl), -(C １～５ alkylene)-CO-cycloalkyl, -(C １～５ (alkylene)-CONH ２ , -(C １～５ alkylene)-CONH(C １～５ alkyl), -(C １～５ alkylene)-CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO-(N-heterocycloalkyl), -(C １～５ alkylene)-NHCO-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)-CO-(C １～５ alkyl), -(C １～５ (alkylene)-NHCONH ２ , -(C １～５ alkylene)-NHCONH-(C １～５ alkyl), -(C １～５ alkylene)-NHCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CONH ２ , -(C １～５ alkylene)-N(C １～５ alkyl)CONH-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ (alkylene)-OCONH ２ , -(C １～５ alkylene)-OCONH-(C １～５ alkyl), -(C １～５ alkylene)-OCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-NHCOO(C １～５ alkyl), and -(C １～５ alkylene)-N(C １～５ alkyl)COO-(C １～５ 10. The compound of claim 1, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

14. -Y ｃ２ -R ｃ２ But -(C ０～３ (alkylene)-heterocycloalkyl, —CONH-heterocycloalkyl, —NHCO-heterocycloalkyl, —NH-heterocycloalkyl, —O-heterocycloalkyl, —CO-heterocycloalkyl, —SO ２ -heterocycloalkyl, -(C ０～３ (alkylene)-heterocycloalkenyl, —CONH-heterocycloalkenyl, —NHCO-heterocycloalkenyl, —NH-heterocycloalkenyl, —O-heterocycloalkenyl, —CO-heterocycloalkenyl, —SO ２ -heterocycloalkenyl, -(C ０～３ alkylene)aryl, —CONH-aryl, —NHCO-aryl, —NH-aryl, —O-aryl, —CO-aryl, —SO ２ -aryl, -(C ０～３ (alkylene)heteroaryl, —CONH-heteroaryl, —NHCO-heteroaryl, —NH-heteroaryl, —O-heteroaryl, —CO-heteroaryl, and —SO ２ -heteroaryl, preferably -Y ｃ２ -R ｃ２ But -(C ０～３ (alkylene)-heterocycloalkyl, —CONH-heterocycloalkyl, —NHCO-heterocycloalkyl, —NH-heterocycloalkyl, —O-heterocycloalkyl, —CO-heterocycloalkyl, —SO ２ -heterocycloalkyl, -(C ０～３ alkylene)aryl, —CONH-aryl, —NHCO-aryl, —NH-aryl, —O-aryl, —CO-aryl, —SO ２ -aryl, -(C ０～３ (alkylene)heteroaryl, —CONH-heteroaryl, —NHCO-heteroaryl, —NH-heteroaryl, —O-heteroaryl, —CO-heteroaryl, and —SO ２ -heteroaryl, wherein said heterocycloalkyl, said heterocycloalkenyl, said aryl or said heteroaryl is optionally selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(O)(C １～５ alkyl), -S(O) ２ (C １～５ alkyl), -S(O)(NH)(C １～５ alkyl), -S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -N=S(O)(C １～５ alkyl) (C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CO(C １～５ haloalkyl), —CO-cycloalkyl, —COO(C １～５ alkyl), -COO(C １～５ haloalkyl), -COO-cycloalkyl, -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), —NHCO—(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), -N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -OCONH ２ , -OCONH-(C １～５ alkyl), -OCON(C １～５ alkyl) (C １～５ alkyl), -NHCOO(C １～５ alkyl), -N(C １～５ alkyl)COO-(C １～５ alkyl), -P(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-CN, -(C １～５ alkylene)-OH, -(C １～５ alkylene)-O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -(C １～５ alkylene)-SH, -(C １～５ alkylene)-S(C １～５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -(C １～５ alkylene)-S(O)(C １～５ alkyl), -(C １～５ alkylene)-S(O) ２ (C １～５ alkyl), -(C １～５ alkylene)-S(O)(NH)(C １～５ alkyl), -(C １～５ alkylene)-S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ (alkylene)-NH ２ , -(C １～５ alkylene)-NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ haloalkyl), -(C １～５ alkylene)-(N-heterocycloalkyl), -(C １～５ alkylene)-N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ haloalkyl), -(C １～５ alkylene)-CO-cycloalkyl, -(C １～５ (alkylene)-CONH ２ , -(C １～５ alkylene)-CONH(C １～５ alkyl), -(C １～５ alkylene)-CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO-(N-heterocycloalkyl), -(C １～５ alkylene)-NHCO-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)-CO-(C １～５ alkyl), -(C １～５ (alkylene)-NHCONH ２ , -(C １～５ alkylene)-NHCONH-(C １～５ alkyl), -(C １～５ alkylene)-NHCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CONH ２ , -(C １～５ alkylene)-N(C １～５ alkyl)CONH-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ (alkylene)-OCONH ２ , -(C １～５ alkylene)-OCONH-(C １～５ alkyl), -(C １～５ alkylene)-OCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-NHCOO(C １～５ alkyl), and -(C １～５ alkylene)-N(C １～５ alkyl)COO-(C １～５ 10. The compound of claim 1, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

15. -Y ｃ２ -R ｃ２ But -(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-heterocycloalkenyl, -(C ０～３ alkylene)aryl, and -(C ０～３ alkylene)heteroaryl, preferably -Y ｃ２ -R ｃ２ But -(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)aryl, and -(C ０～３ wherein said heterocycloalkyl, said heterocycloalkenyl, said aryl or said heteroaryl is optionally selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(O)(C １～５ alkyl), -S(O) ２ (C １～５ alkyl), -S(O)(NH)(C １～５ alkyl), -S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -N=S(O)(C １～５ alkyl) (C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CO(C １～５ haloalkyl), —CO-cycloalkyl, —COO(C １～５ alkyl), -COO(C １～５ haloalkyl), -COO-cycloalkyl, -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), —NHCO—(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), -N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -OCONH ２ , -OCONH-(C １～５ alkyl), -OCON(C １～５ alkyl) (C １～５ alkyl), -NHCOO(C １～５ alkyl), -N(C １～５ alkyl)COO-(C １～５ alkyl), -P(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-CN, -(C １～５ alkylene)-OH, -(C １～５ alkylene)-O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -(C １～５ alkylene)-SH, -(C １～５ alkylene)-S(C １～５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -(C １～５ alkylene)-S(O)(C １～５ alkyl), -(C １～５ alkylene)-S(O) ２ (C １～５ alkyl), -(C １～５ alkylene)-S(O)(NH)(C １～５ alkyl), -(C １～５ alkylene)-S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ (alkylene)-NH ２ , -(C １～５ alkylene)-NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ haloalkyl), -(C １～５ alkylene)-(N-heterocycloalkyl), -(C １～５ alkylene)-N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ haloalkyl), -(C １～５ alkylene)-CO-cycloalkyl, -(C １～５ (alkylene)-CONH ２ , -(C １～５ alkylene)-CONH(C １～５ alkyl), -(C １～５ alkylene)-CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO-(N-heterocycloalkyl), -(C １～５ alkylene)-NHCO-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)-CO-(C １～５ alkyl), -(C １～５ (alkylene)-NHCONH ２ , -(C １～５ alkylene)-NHCONH-(C １～５ alkyl), -(C １～５ alkylene)-NHCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CONH ２ , -(C １～５ alkylene)-N(C １～５ alkyl)CONH-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ (alkylene)-OCONH ２ , -(C １～５ alkylene)-OCONH-(C １～５ alkyl), -(C １～５ alkylene)-OCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-NHCOO(C １～５ alkyl), and -(C １～５ alkylene)-N(C １～５ alkyl)COO-(C １～５ 10. The compound of claim 1, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

16. Y ｃ２ is a covalent bond, C １～５ Alkylene, C ２～５ Alkenylene, and C ２～５ alkynylene, wherein said alkylene, said alkenylene and said alkynylene are each optionally selected from halogen, CN, OH, O(C １～５ alkyl), SH, S(C １５ alkyl), NH ２ , NH(C １～５ alkyl), and N(C １～５ alkyl) (C １～５ and further, the alkylene, the alkenylene, or the alkynylene is substituted with one or more groups independently selected from -CH ２ -units are each optionally -O-, NH-, N(C １～５ alkyl)-, CO-, S-, -SO-, and SO ２ -substituted by groups independently selected from R ｃ２ is hydrogen, halo, -OH, -NH ２ , -SH, -CN,C １～２ Alkyl, C ２～１２ Alkenyl, C ２～１２ selected from alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; The alkyl, the alkenyl, or the alkynyl may optionally be a halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), C １～５ Haloalkyl, —SH, —S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), -CO-(N-heterocycloalkyl), -NHCO-(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), -N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -S(O)(C １～５ alkyl), -S(O) ２ (C １～５ alkyl), -S(O)(NH)(C １～５ alkyl), -S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -N=S(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), and -P(O)(O(C １～５ alkyl)) (C １～５ and is substituted by one or more groups independently selected from halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), C １～５ Haloalkyl, —SH, —S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), The cycloalkyl, the heterocycloalkyl, the aryl or the heteroaryl may optionally be selected from the group consisting of halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(O)(C １～５ alkyl), -S(O) ２ (C １～５ alkyl), -S(O)(NH)(C １～５ alkyl), -S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -N=S(O)(C １～５ alkyl) (C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), —NHCO—(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), -N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -P(O)(C １～５ alkyl) (C １～５ alkyl), -P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-CN, -(C １～５ alkylene)-OH, -(C １～５ alkylene)-O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -(C １～５ alkylene)-SH, -(C １～５ alkylene)-S(C １～５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -(C １～５ alkylene)-S(O)(C １～５ alkyl), -(C １～５ alkylene)-S(O) ２ (C １～５ alkyl), -(C １～５ alkylene)-S(O)(NH)(C １～５ alkyl), -(C １～５ alkylene)-S(O)(N(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl))(O(C １～５ alkyl)), -(C １～５ alkylene)-P(O)(O(C １～５ alkyl)) (C １～５ alkyl), -(C １～５ (alkylene)-NH ２ , -(C １～５ alkylene)-NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ haloalkyl), -(C １～５ alkylene)-(N-heterocycloalkyl), -(C １～５ alkylene)-N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ alkyl), -(C １～５ (alkylene)-CONH ２ , -(C １～５ alkylene)-CONH(C １～５ alkyl), -(C １～５ alkylene)-CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO-(N-heterocycloalkyl), -(C １～５ alkylene)-NHCO-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)-CO-(C １～５ alkyl), -(C １～５ (alkylene)-NHCONH ２ , -(C １～５ alkylene)-NHCONH-(C １～５ alkyl), -(C １～５ alkylene)-NHCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CONH ２ , -(C １～５ alkylene)-N(C １～５ alkyl)CONH-(C １～５ alkyl), and -(C １～５ alkylene)-N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), preferably halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -(C １～５ alkylene)-OH, -(C １～５ alkylene)-O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -(C １～５ alkylene)-SH, -(C １～５ alkylene)-S(C １～５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ (alkylene)-NH ２ , -(C １～５ alkylene)-NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), more preferably halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 2. The compound of claim 1, wherein the aryl group is selected from the group consisting of aryl, aryl(alkyl), ...

17. X ２ But C-Y ｃ２ -R ｃ２ and -Y ｃ２ -R ｃ２ But -O-C １～１２ Alkyl, —NH—C １～１２ Alkyl, —N(C １～５ alkyl)-C １～１２ Alkyl, —O—C ２～１２ Alkenyl, —NH—C ２～１２ Alkenyl, —N(C １～５ alkyl)-C ２～１２ Alkenyl, —O—C ２～１２ Alkynyl, —NH—C ２～１２ Alkynyl, —N(C １～５ alkyl)-C ２～１２ Alkynyl, -(C ０～３ alkylene)-cycloalkyl, —CO—(C ０～３ alkylene)-cycloalkyl, -(C ０～３ alkylene)-CO-cycloalkyl, -CONH-(C ０～３ alkylene)-cycloalkyl, (C ０～３ alkylene)-CONH-cycloalkyl, -NHCO-(C ０～３ alkylene)-cycloalkyl, -(C ０～３ alkylene)-NHCO-cycloalkyl, —NH—(C ０～３ alkylene)-cycloalkyl, -(C ０～３ alkylene)-NH-cycloalkyl, —O—(C ０～３ alkylene)-cycloalkyl, -(C ０～３ alkylene)-O-cycloalkyl, —SO ２ -(C ０～３ alkylene)-cycloalkyl, -(C ０～３ (alkylene)-SO ２ -cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, -SO ２ -cycloalkyl, -(C ０～３ alkylene)-heterocycloalkyl, —CO—(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-CO-heterocycloalkyl, -CONH-(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-CONH-heterocycloalkyl, -NHCO-(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-NHCO-heterocycloalkyl, —NH—(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-NH-heterocycloalkyl, —O—(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-O-cycloalkyl, —SO ２ -(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ (alkylene)-SO ２ -heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO ２ -heterocycloalkyl, -(C ０～３ alkylene)-aryl, —CO—(C ０～３ alkylene)-aryl, -(C ０～３ alkylene)-CO-aryl, -CONH-(C ０～３ alkylene)-aryl, -(C ０～３ alkylene)-CONH-aryl, -NHCO-(C ０～３ alkylene)-aryl, -(C ０～３ alkylene)-NHCO-aryl, -NH-(C ０～３ alkylene)-aryl, -(C ０～３ alkylene)-NH-aryl, —O—(C ０～３ alkylene)-aryl, -(C ０～３ alkylene)-O-aryl, —SO ２ -(C ０～３ alkylene)-aryl, -(C ０～３ (alkylene)-SO ２ -aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO ２ -aryl, -(C ０～３ alkylene)-heteroaryl, —CO—(C ０～３ alkylene)-heteroaryl, -(C ０～３ alkylene)-CO-heteroaryl, -CONH-(C ０～３ alkylene)-heteroaryl, -(C ０～３ alkylene)-CONH-heteroaryl, -NHCO-(C ０～３ alkylene)-heteroaryl, -(C ０～３ alkylene)-NHCO-heteroaryl, —NH—(C ０～３ alkylene)-heteroaryl, -(C ０～３ alkylene)-NH-heteroaryl, —O—(C ０～３ alkylene)-heteroaryl, -(C ０～３ alkylene)-O-heteroaryl, —SO ２ -(C ０～３ alkylene)-heteroaryl, -(C ０～３ (alkylene)-SO ２ -heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO ２ -heteroaryl, wherein said alkyl, said alkenyl, or said alkynyl is optionally selected from halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -C １～５ Haloalkyl, —SH, —S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), wherein said cycloalkyl, said heterocycloalkyl, said aryl or said heteroaryl is optionally substituted with one or more groups independently selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 17. The compound of claim 16, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

18. -Y ｃ２ -R ｃ２ But -(C ０～３ alkylene)-heterocycloalkyl, —CO—(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-CO-heterocycloalkyl, -CONH-(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-CONH-heterocycloalkyl, -NHCO-(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-NHCO-heterocycloalkyl, —NH—(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-NH-heterocycloalkyl, —O—(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-O-cycloalkyl, —SO ２ -(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ (alkylene)-SO ２ -heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO ２ -heterocycloalkyl, -(C ０～３ alkylene)-aryl, —CO—(C ０～３ alkylene)-aryl, -(C ０～３ alkylene)-CO-aryl, -CONH-(C ０～３ alkylene)-aryl, -(C ０～３ alkylene)-CONH-aryl, -NHCO-(C ０～３ alkylene)-aryl, -(C ０～３ alkylene)-NHCO-aryl, -NH-(C ０～３ alkylene)-aryl, -(C ０～３ alkylene)-NH-aryl, —O—(C ０～３ alkylene)-aryl, -(C ０～３ alkylene)-O-aryl, —SO ２ -(C ０～３ alkylene)-aryl, -(C ０～３ (alkylene)-SO ２ -aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO ２ -aryl, -(C ０～３ alkylene)-heteroaryl, —CO—(C ０～３ alkylene)-heteroaryl, -(C ０～３ alkylene)-CO-heteroaryl, -CONH-(C ０～３ alkylene)-heteroaryl, -(C ０～３ alkylene)-CONH-heteroaryl, -NHCO-(C ０～３ alkylene)-heteroaryl, -(C ０～３ alkylene)-NHCO-heteroaryl, —NH—(C ０～３ alkylene)-heteroaryl, -(C ０～３ alkylene)-NH-heteroaryl, —O—(C ０～３ alkylene)-heteroaryl, -(C ０～３ alkylene)-O-heteroaryl, —SO ２ -(C ０～３ alkylene)-heteroaryl, -(C ０～３ (alkylene)-SO ２ -heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO ２ -heteroaryl, wherein said heterocycloalkyl, said aryl or said heteroaryl is optionally selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 17. The compound of claim 16, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

19. -Y ｃ２ -R ｃ２ But -(C ０～３ (alkylene)-heterocycloalkyl, —CONH-heterocycloalkyl, —NHCO-heterocycloalkyl, —NH-heterocycloalkyl, —O-heterocycloalkyl, —CO-heterocycloalkyl, —SO ２ -heterocycloalkyl, -(C ０～３ alkylene)aryl, —CONH-aryl, —NHCO-aryl, —NH-aryl, —O-aryl, —CO-aryl, —SO ２ -aryl, -(C ０～３ (alkylene)-heteroaryl, —CONH-heteroaryl, —NHCO-heteroaryl, —NH-heteroaryl, —O-heteroaryl, —CO-heteroaryl, and —SO ２ -heteroaryl, wherein said heterocycloalkyl, said aryl or said heteroaryl is optionally selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -NH ２ , —NH(C １～５ alkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 17. The compound of claim 16, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

20. -Y ｃ２ -R ｃ２ But -(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-aryl, and -(C ０～３ alkylene)-heteroaryl, wherein said heterocycloalkyl, said aryl or said heteroaryl is optionally selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 17. The compound of claim 16, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

21. -Y ｃ２ -R ｃ２ is selected from heterocycloalkyl, aryl, and heteroaryl, preferably heterocycloalkyl and heteroaryl, more preferably heterocycloalkyl, wherein said heterocycloalkyl, said aryl, or said heteroaryl is optionally selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ haloalkyl), -S(C １～５ alkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 17. The compound of claim 16, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

22. -Y ｃ２ -R ｃ２ is optionally substituted aryl, preferably -Y ｃ２ -R ｃ２ is phenyl, and optionally is selected from the group consisting of halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ substituted by one or more groups independently selected from Or, -Y ｃ２ -R ｃ２ is optionally substituted heteroaryl, preferably -Y ｃ２ -R ｃ２ is imidazolyl, pyridazinyl, thiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, or indazolyl, and heteroaryl is optionally selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ substituted by one or more groups independently selected from Or, -Y ｃ２ -R ｃ２ is optionally substituted heterocycloalkyl, preferably -Y ｃ２ -R ｃ２ is morpholinyl, 1,1-dioxothiomorpholinyl, azetinyl, pyrrolidinyl, piperidinyl, 6-oxo-1,6-dihydropyridinyl, or piperazinyl, and heterocycloalkyl is optionally selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 17. The compound of claim 16, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

23. -Y ｃ２ -R ｃ２ is piperazinyl, and optionally is selected from the group consisting of halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), and preferably -Y ｃ２ -R ｃ２ optionally, CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ and more preferably, -Y is a piperazinyl (preferably N-piperazinyl) substituted (preferably N-substituted) by -Y alkyl. ｃ２ -R ｃ２ But -CON(C １～５ alkyl) (C １～５ alkyl), preferably -CON(CH ３ ) ２ 17. The compound of claim 16, which is piperazinyl (preferably N-piperazinyl) substituted (preferably N-substituted, preferably at an N atom different from the N atom attached to the ring system shown in formula (I)) by

24. X ４ But, C-R ｃ４ and R ｃ４ But hydrogen, halo, C １～６ Alkyl, C ２～６ Alkynyl, —O(C １～６ alkyl), -S(C １～６ alkyl), -NH(C １～６ alkyl), -N(C １～６ alkyl) (C １～６ alkyl), -CO(C １～６ alkyl), C １～６ haloalkyl, —O(C １～６ haloalkyl), -S(C １～６ haloalkyl), -NH(C １～６ haloalkyl), -N(C １～６ haloalkyl) ２ , -CO(C １～６ haloalkyl), -(C ０～３ alkylene)cycloalkyl, —O—(C ０～３ alkylene)-cycloalkyl, —CO—(C ０～３ alkylene)-cycloalkyl, -(C ０～３ alkylene)-heterocycloalkyl, —O—(C ０～３ alkylene)-heterocycloalkyl, —CO—(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-aryl, —O—(C ０～３ alkylene)-aryl, —CO—(C ０～３ alkylene)-aryl, -(C ０～３ alkylene)-heteroaryl, —O—(C ０～３ alkylene)-heteroaryl and —CO—(C ０～３ alkylene)-heteroaryl; The alkyl or the alkynyl may optionally be selected from the group consisting of halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), C １～５ Haloalkyl, —SH, —S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), —NHCO—(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), and —N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ and is substituted by one or more groups independently selected from halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), wherein said cycloalkyl, said cycloalkenyl, said heterocycloalkyl, said heterocycloalkenyl, said aryl or said heteroaryl is optionally selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -(N-heterocycloalkyl), -CO(C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), -CON(C １～５ alkyl) (C １～５ alkyl), —CO—(N-heterocycloalkyl), —NHCO—(C １～５ alkyl), -N(C １～５ alkyl)-CO-(C １～５ alkyl), -NHCONH ２ , -NHCONH-(C １～５ alkyl), -NHCON(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ alkyl)CONH ２ , -N(C １～５ alkyl)CONH-(C １～５ alkyl), and —N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CN, -(C １～５ alkylene)-OH, -(C １～５ alkylene)-O(C １～５ alkyl), -(C １～５ alkylene)-O(C １～５ haloalkyl), -(C １～５ alkylene)-SH, -(C １～５ alkylene)-S(C １～５ alkyl), -(C １～５ alkylene)-S(C １～５ haloalkyl), -(C １～５ (alkylene)-NH ２ , -(C １～５ alkylene)-NH(C １～５ alkyl), -(C １～５ alkylene)-NH(C １～５ haloalkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl) (C １～５ haloalkyl), -(C １～５ alkylene)-(N-heterocycloalkyl), -(C １～５ alkylene)-N(C １～５ haloalkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO(C １～５ alkyl), -(C １～５ (alkylene)-CONH ２ , -(C １～５ alkylene)-CONH(C １～５ alkyl), -(C １～５ alkylene)-CON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-CO-(N-heterocycloalkyl), -(C １～５ alkylene)-NHCO-(C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)-CO-(C １～５ alkyl), -(C １～５ (alkylene)-NHCONH ２ , -(C １～５ alkylene)-NHCONH-(C １～５ alkyl), -(C １～５ alkylene)-NHCON(C １～５ alkyl) (C １～５ alkyl), -(C １～５ alkylene)-N(C １～５ alkyl)CONH ２ , -(C １～５ alkylene)-N(C １～５ alkyl)CONH-(C １～５ alkyl), and -(C １～５ alkylene)-N(C １～５ alkyl)CON(C １～５ alkyl) (C １～５ alkyl), preferably halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 2. The compound of claim 1, wherein the aryl group is selected from the group consisting of aryl, aryl(alkyl), ...

25. X ４ But, C-R ｃ４ and R ｃ４ But hydrogen, halo, C １～６ Alkyl, C ２～６ Alkynyl, —O—C １～６ Alkyl, —S—C １～６ Alkyl, —NH—C １～６ Alkyl, C １～６ Haloalkyl, -(C ０～３ alkylene)-cycloalkyl, -(C ０～３ alkylene)-heterocycloalkyl, -(C ０～３ alkylene)-aryl and -(C ０～３ alkylene)-heteroaryl, wherein said alkyl is optionally selected from halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), —O(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), wherein said cycloalkyl, said heterocycloalkyl, said aryl or said heteroaryl is optionally substituted with one or more groups independently selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ haloalkyl), -S(C １～５ alkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 10. The compound of claim 1, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

26. R ｃ４ But hydrogen, halo, C １～６ Alkyl, C ２～６ Alkynyl, —O—C １～６ Alkyl, —S—C １～６ Alkyl, —NH—C １～６ Alkyl, and C １～６ haloalkyl, preferably R ｃ４ But hydrogen, halo, C １～２ Alkyl, and C ２～３ alkynyl, more preferably R ｃ４ is hydrogen, halo, and C １～２ alkyl, and even more preferably R ｃ４ 26. The compound of claim 25, wherein is hydrogen or halo.

27. X ５ But, C-R ｃ５ and R ｃ５ But hydrogen, halo, C １～３ Alkyl, —O—C １～３ Alkyl, —S—C １～３ Alkyl, —NH—C １～３ Alkyl, and C １～３ haloalkyl, preferably R ｃ５ But hydrogen, halo, C １～３ Alkyl, and C １～３ The compound of claim 1 selected from haloalkyl.

28. The compound of claim 1, wherein X 5 is N.

29. R Ｒ５ But C １～１２ Alkyl, C １～１２ Alkenyl, C ２～１２ selected from alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; The alkyl, the alkenyl, or the alkynyl may optionally be a halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ and wherein said cycloalkyl, said heterocycloalkyl, said aryl or said heteroaryl is optionally substituted with one or more groups independently selected from halogen, —CN, —OH, —C １～５ Alkyl, -C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -SO(C １～５ alkyl), -SO ２ (C １～５ alkyl), -S(C １～５ haloalkyl), —SO(C １～５ haloalkyl), -SO ２ (C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), preferably halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 2. The compound of claim 1, wherein the aryl group is selected from the group consisting of aryl, aryl(alkyl), ...

30. R ４ But -(C ０～２ alkylene)-cycloalkyl, —CO—(C ０～２ alkylene)-cycloalkyl, -(C ０～２ alkylene)-CO-cycloalkyl, -CONH-(C ０～２ alkylene)-cycloalkyl, -(C ０～２ alkylene)-CONH-cycloalkyl, -NHCO-(C ０～２ alkylene)-cycloalkyl, -(C ０～２ alkylene)-NHCO-cycloalkyl, —NH—(C ０～２ alkylene)-cycloalkyl, -(C ０～２ alkylene)-NH-cycloalkyl, —O—(C ０～２ alkylene)-cycloalkyl, -(C ０～２ alkylene)-O-cycloalkyl, SO ２ -(C ０～２ alkylene)-cycloalkyl, -(C ０～２ alkylene)SO ２ -cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, SO ２ -cycloalkyl, -(C ０～２ alkylene)-cycloalkenyl, —CO—(C ０～２ alkylene)-cycloalkenyl, -(C ０～２ alkylene)-CO-cycloalkenyl, -CONH-(C ０～２ alkylene)-cycloalkenyl, -(C ０～２ alkylene)-CONH-cycloalkenyl, -NHCO-(C ０～２ alkylene)-cycloalkenyl, -(C ０～２ alkylene)-NHCO-cycloalkenyl, -NH-(C ０～２ alkylene)-cycloalkenyl, -(C ０～２ alkylene)-NH-cycloalkenyl, —O—(C ０～２ alkylene)-cycloalkenyl, -(C ０～２ alkylene)-O-cycloalkenyl, SO ２ -(C ０～２ alkylene)-cycloalkenyl, -(C ０～２ alkylene)SO ２ -cycloalkenyl, -CONH-cycloalkenyl, -NHCO-cycloalkenyl, -NH-cycloalkenyl, -O-cycloalkenyl, -CO-cycloalkenyl, SO ２ -cycloalkenyl, -(C ０～２ alkylene)-heterocycloalkyl, —CO—(C ０～２ alkylene)-heterocycloalkyl, -(C ０～２ alkylene)-CO-heterocycloalkyl, -CONH-(C ０～２ alkylene)-heterocycloalkyl, -(C ０～２ alkylene)-CONH-heterocycloalkyl, -NHCO-(C ０～２ alkylene)-heterocycloalkyl, -(C ０～２ alkylene)-NHCO-heterocycloalkyl, —NH—(C ０～２ alkylene)-heterocycloalkyl, -(C ０～２ alkylene)-NH-heterocycloalkyl, —O—(C ０～２ alkylene)-heterocycloalkyl, -(C ０～２ alkylene)-O-heterocycloalkyl, SO ２ -(C ０～２ alkylene)-heterocycloalkyl, -(C ０～２ alkylene)SO ２ -heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, SO ２ -heterocycloalkyl, -(C ０～２ alkylene)-heterocycloalkenyl, —CO—(C ０～２ alkylene)-heterocycloalkenyl, -(C ０～２ alkylene)-CO-heterocycloalkenyl, -CONH-(C ０～２ alkylene)-heterocycloalkenyl, -(C ０～２ alkylene)-CONH-heterocycloalkenyl, -NHCO-(C ０～２ alkylene)-heterocycloalkenyl, -(C ０～２ alkylene)-NHCO-heterocycloalkenyl, -NH-(C ０～２ alkylene)-heterocycloalkenyl, -(C ０～２ alkylene)-NH-heterocycloalkenyl, —O—(C ０～２ alkylene)-heterocycloalkenyl, -(C ０～２ alkylene)-O-heterocycloalkenyl, SO ２ -(C ０～２ alkylene)-heterocycloalkenyl, -(C ０～２ alkylene)SO ２ -heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, -CO-heterocycloalkenyl, SO ２ -heterocycloalkenyl, -(C ０～２ alkylene)-aryl, —CO—(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-CO-aryl, -CONH-(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-CONH-aryl, -NHCO-(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-NHCO-aryl, -NH-(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-NH-aryl, —O—(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-O-aryl, SO ２ -(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)SO ２ -aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, SO ２ -aryl, -(C ０～２ alkylene)-heteroaryl, —CO—(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)-CO-heteroaryl, -CONH-(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)-CONH-heteroaryl, -NHCO-(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)-NHCO-heteroaryl, —NH—(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)-NH-heteroaryl, —O—(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)-O-heteroaryl, SO ２ -(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)SO ２ -heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl, and SO ２ -heteroaryl, wherein said cycloalkyl, said cycloalkenyl, said heterocycloalkyl, said heterocycloalkenyl, said aryl or said heteroaryl is optionally selected from halogen, —CN, —OH, —C １～５ Alkyl, -C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -SO(C １～５ alkyl), -SO ２ (C １～５ alkyl), -S(C １～５ haloalkyl), —SO(C １～５ haloalkyl), -SO ２ (C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), preferably halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 2. The compound of claim 1, wherein the aryl group is selected from the group consisting of aryl, aryl(alkyl), ...

31. R ４ However, (C ０～２ alkylene)-cycloalkyl, —CO—(C ０～２ alkylene)-cycloalkyl, -(C ０～２ alkylene)-CO-cycloalkyl, -CONH-(C ０～２ alkylene)-cycloalkyl, -(C ０～２ alkylene)-CONH-cycloalkyl, -NHCO-(C ０～２ alkylene)-cycloalkyl, -(C ０～２ alkylene)-NHCO-cycloalkyl, —NH—(C ０～２ alkylene)-cycloalkyl, -(C ０～２ alkylene)-NH-cycloalkyl, —O—(C ０～２ alkylene)-cycloalkyl, -(C ０～２ alkylene)-O-cycloalkyl, —SO ２ -(C ０～２ alkylene)-cycloalkyl, -(C ０～２ (alkylene)-SO ２ -cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, -SO ２ -cycloalkyl, -(C ０～２ alkylene)-heterocycloalkyl, —CO—(C ０～２ alkylene)-heterocycloalkyl, -(C ０～２ alkylene)-CO-heterocycloalkyl, -CONH-(C ０～２ alkylene)-heterocycloalkyl, -(C ０～２ alkylene)-CONH-heterocycloalkyl, -NHCO-(C ０～２ alkylene)-heterocycloalkyl, -(C ０～２ alkylene)-NHCO-heterocycloalkyl, —NH—(C ０～２ alkylene)-heterocycloalkyl, -(C ０～２ alkylene)-NH-heterocycloalkyl, —O—(C ０～２ alkylene)-heterocycloalkyl, -(C ０～２ alkylene)-O-heterocycloalkyl, —SO ２ -(C ０～２ alkylene)-heterocycloalkyl, -(C ０～２ (alkylene)-SO ２ -heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO ２ -heterocycloalkyl, -(C ０～２ alkylene)-aryl, —CO—(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-CO-aryl, -CONH-(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-CONH-aryl, -NHCO-(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-NHCO-aryl, -NH-(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-NH-aryl, —O—(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-O-aryl, —SO ２ -(C ０～２ alkylene)-aryl, -(C ０～２ (alkylene)-SO ２ -aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO ２ -aryl, -(C ０～２ alkylene)-heteroaryl, —CO—(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)-CO-heteroaryl, -CONH-(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)-CONH-heteroaryl, -NHCO-(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)-NHCO-heteroaryl, —NH—(C ０～２ alkylene)heteroaryl, -(C ０～２ alkylene)-NH-heteroaryl, —O—(C ０～２ alkylene)heteroaryl, -(C ０～２ alkylene)-O-heteroaryl, —SO ２ -(C ０～２ alkylene)heteroaryl, -(C ０～２ (alkylene)-SO ２ -heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl, and -SO ２ -heteroaryl, wherein said cycloalkyl, said heterocycloalkyl, said aryl or said heteroaryl is optionally selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 10. The compound of claim 1, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

32. R ４ But -(C ０～２ alkylene)-aryl, —CO—(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-CO-aryl, -CONH-(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-CONH-aryl, -NHCO-(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-NHCO-aryl, -NH-(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-NH-aryl, —O—(C ０～２ alkylene)-aryl, -(C ０～２ alkylene)-O-aryl, —SO ２ -(C ０～２ alkylene)-aryl, -(C ０～２ (alkylene)-SO ２ -aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO ２ -aryl, -(C ０～２ alkylene)-heteroaryl, —CO—(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)-CO-heteroaryl, -CONH-(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)-CONH-heteroaryl, -NHCO-(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)-NHCO-heteroaryl, —NH—(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)-NH-heteroaryl, —O—(C ０～２ alkylene)-heteroaryl, -(C ０～２ alkylene)-O-heteroaryl, —SO ２ -(C ０～２ alkylene)-heteroaryl, -(C ０～２ (alkylene)-SO ２ -heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl, and -SO ２ -heteroaryl, wherein said aryl or said heteroaryl is optionally selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 10. The compound of claim 1, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

33. R ４ But C １～１２ Alkyl, C ２～１２ Alkenyl, C ２～１２ alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, preferably R ４ is selected from cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, more preferably R ４ is selected from aryl and heteroaryl, and even more preferably, R ４ is heteroaryl, and said alkyl, said alkenyl, or said alkynyl is optionally selected from halogen, —CN, —OH, —O(C １～５ alkyl), —O(C １～５ haloalkyl), SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), wherein said cycloalkyl, said heterocycloalkyl, said aryl or said heteroaryl is optionally substituted with one or more groups independently selected from halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ 10. The compound of claim 1, wherein the compound is substituted with one or more groups independently selected from the group consisting of alkyl, aryl, arylsulfonyl ...

34. R ４ is a 5-membered heteroaryl, optionally containing halogen, —CN, —OH, C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), —O(C １～５ haloalkyl), -SH, -S(C １～５ alkyl), -S(C １～５ haloalkyl), -NH ２ , —NH(C １～５ alkyl), -NH(C １～５ haloalkyl), -N(C １～５ alkyl) (C １～５ alkyl), -N(C １～５ haloalkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ and substituted by one or more groups independently selected from: imidazolyl, isoxazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, thiazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, or 1,3,4-thiadiazolyl; preferably, said 5-membered heteroaryl is 1,2,4-thiadiazolyl, and optionally, halogen, —CN, —OH, —C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), -SH, -S(C １～５ alkyl), -NH ２ , —NH(C １～５ alkyl), -N(C １～５ alkyl) (C １～５ alkyl), -CONH ２ , -CONH(C １～５ alkyl), and —CON(C １～５ alkyl) (C １～５ alkyl), and preferably optionally substituted by one or more groups independently selected from C １～５ Alkyl, C １～５ haloalkyl, —O(C １～５ alkyl), -SH, -S(C １～５ alkyl), more preferably optionally substituted by C １～５ Alkyl, C １～５ haloalkyl, and even more preferably optionally substituted by C １～５ Substituted by haloalkyl, preferably -CH ２ F, -CHF ２ and CF ３ and most preferably, optionally, —CHF ２ 34. The compound of claim 33, substituted by:

35. A compound of formula (Iz): 【Chemistry 2】 or an enantiomer, diastereomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystalline form, pharmaceutically acceptable salt or prodrug thereof, wherein R 1 , X 2 and R C4 are as defined in any one of claims 1 to 6 or 11 to 26.

36. 【Chemical 3】 【Chemistry 4】 【Chemistry 5】 or a pharmaceutically acceptable salt, hydrate or solvate thereof.

37. Formula: 【Chemistry 6】 Compounds of or a pharmaceutically acceptable salt thereof.

38. 8-chloro-N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 4-(6-(N-(1-cyanocyclopropyl)sulfamoyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; (R)—N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(2-methylmorpholino)imidazo[1,2-a]pyridine-6-sulfonamide; 8-chloro-N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 4-(6-(N-(1-cyanocyclopropyl)sulfamoyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 1,8-dichloro-N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)imidazo[1,5-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(2-oxa-7-azaspiro[3.5]nonan-7-yl)imidazo[1,2-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-isobutyrylpiperazin-1-yl)imidazo[1,2-a]pyridine-6-sulfonamide; N-(2-((6-(N-(1-cyanocyclopropyl)sulfamoyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)imidazo[1,2-a]pyridin-8-yl)(methyl)amino)ethyl)-N-methylisobutyramide; [8-chloro-N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)indolizine-6-sulfonamide; Ethyl 8-chloro-6-(N-(1-cyanocyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxylate; Ethyl 6-(N-(1-cyanocyclopropyl)sulfamoyl)-8-(4-(dimethylcarbamoyl)piperazin-1-yl)imidazo[1,2-a]pyridine-3-carboxylate; 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(methoxymethyl)piperidinyl)imidazo[1,5-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-methoxypiperidin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(hydroxymethyl)piperidin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-1-iodo-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 1,8-dichloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 1,8-dichloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(hydroxymethyl)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(2-hydroxypropan-2-yl)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(methoxymethyl)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(methoxymethyl)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(1-hydroxyethyl)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; Chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(1-hydroxyethyl)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(2-hydroxypropan-2-yl)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 1,8-dichloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 4-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; tert-butyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-3,6-dihydropyridine-1(2H)-carboxylate; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(1,2,3,6-tetrahydropyridin-4-yl)imidazo[1,5-a]pyridine-6-sulfonamide; (3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethyl-3,6-dihydropyridine-1(2H)-carboxamide; 4-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethyl-3,6-dihydropyridine-1(2H)-carboxamide; tert-butyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)piperazine-1-carboxylate; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(piperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-isobutyrylpiperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; tert-butyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-3,6-dihydropyridine-1(2H)-carboxylate; tert-butyl 4-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-3,6-dihydropyridine-1(2H)-carboxylate; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(1,2,3,6-tetrahydropyridin-4-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 4-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethyl-3,6-dihydropyridine-1(2H)-carboxamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(2-oxa-7-azaspiro[3.5]nonan-7-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-oxa-7-azaspiro[3.5]nonan-7-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(1,2,3,6-tetrahydropyridin-4-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethyl-3,6-dihydropyridine-1(2H)-carboxamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-oxa-7-azaspiro[3.5]nonan-7-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-((dimethyl(oxo)-16-sulfanylidene)amino)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(6-(hydroxymethyl)-3-azabicyclo[3.1.1]heptan-3-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(2-oxa-7-azaspiro[3.5]nonan-7-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(4-(methylthio)piperidin-1-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(4-(S-methylsulfonimidoyl)piperidin-1-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(4-(methylsulfonyl)piperidin-1-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(4-(methylsulfinyl)piperidin-1-yl)imidazo[1,2-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(2-oxa-6-azaspiro[3.4]octan-6-yl)imidazo[1,2-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((cis)-hexahydrofuro[3,4-c]pyridin-5(3H)-yl)imidazo[1,2-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((trans)-hexahydrofuro[3,4-c]pyridin-5(3H)-yl)imidazo[1,2-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(8-(hydroxymethyl)-3-azabicyclo[3.2.1]octan-3-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(6-oxa-2-azaspiro[3.4]octan-2-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(hydroxymethyl)-2-methylpiperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((cis)-hexahydrofuro[3,4-c]pyridin-5(3H)-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((trans)-hexahydrofuro[3,4-c]pyridin-5(3H)-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(dimethylphosphoryl)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(6-hydroxy-2-azaspiro[3.3]heptan-2-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((1R,3s,5S)-3-(hydroxymethyl)-8-azabicyclo[3.2.1]octan-8-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((1R,3r,5S)-3-(hydroxymethyl)-8-azabicyclo[3.2.1]octan-8-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(4-(trifluoromethyl)piperidin-1-yl)imidazo[1,2-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((2-hydroxy-2-methylpropyl)(methyl)amino)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-((dimethylamino)methyl)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 8-(2,2-difluoro-7-azaspiro[3.5]nonan-7-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 8-(4-(aminomethyl)piperidin-1-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine-6-sulfonamide; tert-butyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-3,6-dihydropyridine-1(2H)-carboxylate; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(1,2,3,6-tetrahydropyridin-4-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethyl-3,6-dihydropyridine-1(2H)-carboxamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(3-hydroxy-3-methylbut-1-yn-1-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(3-hydroxy-3-methylbutyl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; Ethyl 8-chloro-6-(N-(1-cyanocyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxylate; Ethyl 8-chloro-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxylate; 8-chloro-N-isobutyl-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide; N-isobutyl-6-(N-(1-methylcyclopropyl)sulfamoyl)-8-(2-oxa-7-azaspiro[3.5]nonan-7-yl)imidazo[1,2-a]pyridine-3-carboxamide; Methyl 6-(N-(1-methylcyclopropyl)sulfamoyl)-8-(2-oxa-7-azaspiro[3.5]nonan-7-yl)imidazo[1,2-a]pyridine-3-carboxylate; Ethyl 8-(4-(dimethylcarbamoyl)piperazin-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxylate; Methyl 8-(4-(dimethylcarbamoyl)piperazin-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxylate; 8-(4-(dimethylcarbamoyl)piperazin-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)-N-(oxetan-3-yl)imidazo[1,2-a]pyridine-3-carboxamide; 6-(N-(1-cyanocyclopropyl)sulfamoyl)-8-(4-(dimethylcarbamoyl)piperazin-1-yl)-N-ethylimidazo[1,2-a]pyridine-3-carboxamide; 4-(6-(N-(1-cyanocyclopropyl)sulfamoyl)-3-(morpholine-4-carbonyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 6-(N-(1-cyanocyclopropyl)sulfamoyl)-8-(4-(dimethylcarbamoyl)piperazin-1-yl)-N-ethyl-N-methylimidazo[1,2-a]pyridine-3-carboxamide; 6-(N-(1-cyanocyclopropyl)sulfamoyl)-N-(cyanomethyl)-8-(4-(dimethylcarbamoyl)piperazin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide 2,2,2-trifluoroacetate; 6-(N-(1-cyanocyclopropyl)sulfamoyl)-8-(4-(dimethylcarbamoyl)piperazin-1-yl)-N-(prop-2-yn-1-yl)imidazo[1,2-a]pyridine-3-carboxamide; N-(cyanomethyl)-6-(N-(1-methylcyclopropyl)sulfamoyl)-8-(2-oxa-7-azaspiro[3.5]nonan-7-yl)imidazo[1,2-a]pyridine-3-carboxamide; 8-(4-(dimethylcarbamoyl)piperazin-1-yl)-N-(1-methylazetidin-3-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide; 8-(4-(dimethylcarbamoyl)piperazin-1-yl)-N-methyl-6-(N-(1-methylcyclopropyl)sulfamoyl)-N-(oxetan-3-yl)imidazo[1,2-a]pyridine-3-carboxamide; N-cyclobutyl-8-(4-(dimethylcarbamoyl)piperazin-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide; 8-(4-(dimethylcarbamoyl)piperazin-1-yl)-N-((1s,3s)-3-fluorocyclobutyl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide; 8-(4-(dimethylcarbamoyl)piperazin-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)-N-(tetrahydro-2H-pyran-4-yl)imidazo[1,2-a]pyridine-3-carboxamide; 8-(4-(dimethylcarbamoyl)piperazin-1-yl)-N-(2-methoxyethyl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide; Ethyl 8-(4-(dimethylcarbamoyl)piperazin-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxylate; N,N-dimethyl-4-(6-(N-(1-methylcyclopropyl)sulfamoyl)-3-(5-methylpyridin-2-yl)imidazo[1,2-a]pyridin-8-yl)piperazine-1-carboxamide; N,N-dimethyl-4-(6-(N-(1-methylcyclopropyl)sulfamoyl)-3-(6-methylpyridin-3-yl)imidazo[1,2-a]pyridin-8-yl)piperazine-1-carboxamide; 4-(3-ethyl-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; N,N-dimethyl-4-(3-(3-methylbut-1-yn-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)piperazine-1-carboxamide; 4-(3-ethynyl-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; N,N-dimethyl-4-(6-(N-(1-methylcyclopropyl)sulfamoyl)-3-(prop-1-yn-1-yl)imidazo[1,2-a]pyridin-8-yl)piperazine-1-carboxamide; N,N-dimethyl-4-(6-(N-(1-methylcyclopropyl)sulfamoyl)-3-propylimidazo[1,2-a]pyridin-8-yl)piperazine-1-carboxamide; N,N-dimethyl-4-(6-(N-(1-methylcyclopropyl)sulfamoyl)-3-(trifluoromethyl)imidazo[1,2-a]pyridin-8-yl)piperazine-1-carboxamide; N,N-dimethyl-4-(3-(1-methyl-1H-pyrazol-3-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)piperazine-1-carboxamide; N,N-dimethyl-4-(3-(1-methyl-1H-pyrazol-4-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)piperazine-1-carboxamide; 4-(3-(6-(difluoromethyl)pyridin-3-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; N,N-dimethyl-4-(6-(N-(1-methylcyclopropyl)sulfamoyl)-3-vinylimidazo[1,2-a]pyridin-8-yl)piperazine-1-carboxamide; N,N-dimethyl-4-(6-(N-(1-methylcyclopropyl)sulfamoyl)-3-(2-methylprop-1-en-1-yl)imidazo[1,2-a]pyridin-8-yl)piperazine-1-carboxamide; 4-(3-isobutyl-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; N,N-dimethyl-4-(3-(3-methylbut-1-yn-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)piperazine-1-carboxamide; 4-(6-(N-(1-cyanocyclopropyl)sulfamoyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)indolizin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 4-(1-chloro-6-(N-(1-cyanocyclopropyl)sulfamoyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)indolizin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-1-iodo-N-(1-methylcyclopropyl)indolizine-6-sulfonamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)indolizine-6-sulfonamide; 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)indolizin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 1,8-dichloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)indolizine-6-sulfonamide; 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)indolizin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 4-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)indolizin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 1-bromo-8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)indolizine-6-sulfonamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-1-(3-methyl-3-(methylamino)but-1-yn-1-yl)indolizine-6-sulfonamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-1-(3-hydroxyprop-1-yn-1-yl)indolizine-6-sulfonamide; 1-(azetidin-3-ylmethyl)-8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)indolizine-6-sulfonamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-1-isobutylindolizine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)indolizine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-1-isobutylindolizine-6-sulfonamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-1-(1,2,3,6-tetrahydropyridin-4-yl)indolizine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-oxa-7-azaspiro[3.5]nonan-7-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 4-(7-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 4-(1,7-dichloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 4-(7-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; tert-butyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)piperidine-1-carboxylate; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(piperidin-4-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperidine-1-carboxamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-1-(3-methoxyprop-1-yn-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-1-(3-methoxypropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-1-(3-methoxypropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(3-methoxypropoxy)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(3-methoxypropoxy)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-((tetrahydro-2H-pyran-4-yl)oxy)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-((tetrahydro-2H-pyran-4-yl)oxy)imidazo[1,5-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-1-iodo-8-(3-methoxypropoxy)imidazo[1,5-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(3-methoxypropoxy)imidazo[1,5-a]pyridine-6-sulfonamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-1-fluoro-N-(1-(fluoromethyl)cyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-1-fluoro-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-1-methylimidazo[1,5-a]pyridine-6-sulfonamide; 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)-1-methylimidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 8-chloro-N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)thiazol-2-yl)-1-iodoimidazo[1,5-a]pyridine-6-sulfonamide; 8-chloro-N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)thiazol-2-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 4-(6-(N-(1-cyanocyclopropyl)sulfamoyl)-3-(5-(difluoromethyl)thiazol-2-yl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(hydroxymethyl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((trans)-hexahydrofuro[3,4-c]pyridin-5(3H)-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-oxa-7-azaspiro[4.4]nonan-7-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-oxa-6-azaspiro[3.4]octan-6-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(2-hydroxypropan-2-yl)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-oxa-6-azaspiro[3.3]heptan-6-yl)imidazo[1,5-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(methyl(tetrahydro-2H-pyran-4-yl)amino)imidazo[1,5-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((3-methoxypropyl)(methyl)amino)imidazo[1,5-a]pyridine-6-sulfonamide; N-(1-cyanocyclopropyl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((tetrahydro-2H-pyran-4-yl)amino)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(4-acetylpiperazin-1-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-oxa-6-azaspiro[3.4]octan-6-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((cis)-hexahydrofuro[3,4-c]pyridin-5(3H)-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-oxa-7-azaspiro[4.4]nonan-7-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(1-methoxyethyl)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; Oxetan-3-yl 8-(4-(dimethylcarbamoyl)piperazin-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxylate; 4-(3-(2-chloroacetamido)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 4-(3-(2-cyanoacetamido)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 4-(3-acetyl-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 4-(3-(1-hydroxyethyl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-isobutyrylpiperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 4-(3-(methoxymethyl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(N,S-dimethylsulfonimidoyl)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; tert-butyl 6-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-2,6-diazaspiro[3.4]octane-2-carboxylate; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2,6-diazaspiro[3.4]octan-6-yl)imidazo[1,5-a]pyridine-6-sulfonamide; tert-butyl 4-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)piperazine-1-carboxylate; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(piperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 4-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N-methylpiperazine-1-carboxamide; (S)-tert-butyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-2-methylpiperazine-1-carboxylate; (S)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(3-methylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; (S)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-isobutyryl-3-methylpiperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; (S)-tert-butyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-2-ethylpiperazine-1-carboxylate; (S)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(3-ethylpiperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; (R)-tert-butyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-2-ethylpiperazine-1-carboxylate; (R)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(3-ethylpiperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N-(2-(dimethylamino)ethyl)-N-methylpiperazine-1-carboxamide; tert-butyl 3-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-3,6-diazabicyclo[3.2.1]octane-6-carboxylate; 8-(3,6-diazabicyclo[3.2.1]octan-3-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; tert-butyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-5,6-dihydropyridine-1(2H)-carboxylate; tert-butyl 4-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-5,6-dihydropyridine-1(2H)-carboxylate; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(1,2,3,6-tetrahydropyridin-4-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-8-(4-cyclopropylpiperazin-1-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; tert-butyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)piperazine-1-carboxylate; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(piperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(4-isobutyrylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; tert-butyl 4-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)piperazine-1-carboxylate; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(piperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; tert-butyl 2-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-2,6-diazaspiro[3.4]octane-6-carboxylate; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2,6-diazaspiro[3.4]octan-2-yl)imidazo[1,5-a]pyridine-6-sulfonamide; (S)-tert-butyl 4-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-2-methylpiperazine-1-carboxylate; (S)-1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(3-methylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; (R)-1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(3-methylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 1,8-dichloro-3-(5-(difluoromethyl)thiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 4-(1-chloro-3-(5-(difluoromethyl)thiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 4-(3-(5-(difluoromethyl)thiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 1-chloro-3-(5-(difluoromethyl)thiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(2-oxa-7-azaspiro[3.5]nonan-7-yl)imidazo[1,5-a]pyridine-6-sulfonamide; (R)-tert-butyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-2-methylpiperazine-1-carboxylate; (R)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(3-methylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; (R)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-isobutyryl-3-methylpiperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(2-oxa-7-azaspiro[3.5]nonan-7-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(4-isobutyrylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(3-(methylsulfonyl)azetidin-1-yl)imidazo[1,2-a]pyridine-6-sulfonamide; (S)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(3-(methylsulfonyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-oxa-8-azaspiro[4.5]decan-8-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(2,2-dioxide-2-thia-7-azaspiro[3.5]nonan-7-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; (R)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(3-(methylsulfonyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 8-(4-(cyclopropanecarbonyl)piperazin-1-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(4-(2,2,2-trifluoroacetyl)piperazin-1-yl)imidazo[1,2-a]pyridine-6-sulfonamide; Methyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)piperazine-1-carboxylate; Isopropyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)piperazine-1-carboxylate; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(6-oxooctahydro-2H-pyrido[1,2-a]pyrazin-2-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(4-(1,1,1-trifluoropropan-2-yl)piperazin-1-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(2-oxa-7-azaspiro[3.5]nonan-7-yl)indolizine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2,7-diazaspiro[3.5]nonan-7-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(4-cyclopropylpiperazin-1-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(3,8-diazabicyclo[3.2.1]octan-3-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(cis)-octahydro-5H-pyrrolo[3,4-c]pyridin-5-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2,6-diazaspiro[3.3]heptan-2-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2,6-diazaspiro[3.3]heptan-2-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-((3aR,7aS)-octahydro-5H-pyrrolo[3,4-c]pyridin-5-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(4,7-diazaspiro[2.5]octan-7-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-1-(3-methoxyprop-1-yn-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(cis)-octahydro-5H-pyrrolo[3,4-c]pyridin-5-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(2,5-diazabicyclo[2.2.2]octan-2-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(4,7-diazaspiro[2.5]octan-7-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2,6-diazaspiro[3.4]octan-2-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2,7-diazaspiro[3.5]nonan-2-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2,6-diazaspiro[3.4]octan-2-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(4-methylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(4-methylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(1-methoxyethyl)piperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-8-(1,4-diazepan-1-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(1,4-diazepan-1-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2,7-diazaspiro[3.5]nonan-7-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(2,5-diazabicyclo[2.2.2]octan-2-yl)-1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(3,9-diazabicyclo[4.2.1]nonan-3-yl)-1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(3,6-diazabicyclo[3.2.1]octan-3-yl)-1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; N-cyclopentyl-8-(4-(dimethylcarbamoyl)piperazin-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide; N-(3,3-difluorocyclobutyl)-8-(4-(dimethylcarbamoyl)piperazin-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide; 8-(4-(dimethylcarbamoyl)piperazin-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)-N-(tetrahydrofuran-3-yl)imidazo[1,2-a]pyridine-3-carboxamide; 8-(4-(dimethylcarbamoyl)piperazin-1-yl)-N-((1r,3r)-3-fluorocyclobutyl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(piperazin-1-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 8-(4-(2,2-difluoroacetyl)piperazin-1-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(3,6-dihydro-2H-pyran-4-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(2-oxa-7-azaspiro[3.5]nonan-7-yl)imidazo[1,2-a]pyridine-6-sulfonamide; tert-butyl (R)-4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-3-methylpiperazine-1-carboxylate; (R)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-methylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; (R)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-isobutyryl-2-methylpiperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; tert-butyl (S)-4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-3-methylpiperazine-1-carboxylate; (S)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-methylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; (S)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-isobutyryl-2-methylpiperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(4-(2,2-difluoroethyl)piperazin-1-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(2-fluoroethyl)piperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 4-(3-(5-(difluoromethyl)pyrazin-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-oxaspiro[3.5]non-6-en-7-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 4-(3-(cyclopent-1-en-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 4-(3-cyclopentyl-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 8-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-1-(3-methoxyprop-1-yn-1-yl)indolizine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-ethylpiperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; (R)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(6-oxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)imidazo[1,2-a]pyridine-6-sulfonamide; (R)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(3-oxotetrahydro-3H-oxazolo[3,4-a]pyrazin-7(1H)-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-((3aR,6aS)-tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)imidazo[1,2-a]pyridine-6-sulfonamide; (S)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(6-oxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-((3aR,7aS)-octahydro-5H-pyrrolo[3,4-c]pyridin-5-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-oxa-8-azaspiro[4.5]decan-8-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2-oxa-8-azaspiro[4.5]decan-8-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(2,7-diazaspiro[3.5]nonan-2-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((3S,5R)-3,5-dimethylpiperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-((trans)-tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)imidazo[1,2-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(hexahydro-5H-furo[2,3-c]pyrrol-5-yl)-N-(1-methylcyclopropyl)imidazo[1,2-a]pyridine-6-sulfonamide; 8-cis-8-azabicyclo[3.2.1]oct-2-en-3-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 4-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N-(2-(dimethylamino)ethyl)-N-methylpiperazine-1-carboxamide; tert-butyl-3-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate; tert-butyl-3-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate; 8-((1R,5S)-8-azabicyclo[3.2.1]oct-2-en-3-yl)-1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(dimethylalanyl)piperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-(1-methylazetidine-3-carbonyl)piperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; tert-butyl (R)-4-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-2-methylpiperazine-1-carboxylate; (R)-1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(3-methylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; tert-butyl (2R,6R)-4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-2,6-dimethylpiperazine-1-carboxylate; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((3R,5R)-3,5-dimethylpiperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; tert-butyl (2S,6S)-4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-2,6-dimethylpiperazine-1-carboxylate; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-((3S,5S)-3,5-dimethylpiperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 4-(3-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; tert-butyl (S)-4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-(fluoromethyl)cyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-2-methylpiperazine-1-carboxylate; (S)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(3-methylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; tert-butyl 4-(3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-2-(trifluoromethyl)piperazine-1-carboxylate; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(3-(trifluoromethyl)piperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(3-(methoxymethyl)piperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(3-(methoxymethyl)piperazin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(3-cyclopropylpiperazin-1-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; Cyclobutyl 8-(4-(dimethylcarbamoyl)piperazin-1-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxylate; 4-(1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-6-(N-(1-methylcyclopropyl)sulfamoyl)imidazo[1,5-a]pyridin-8-yl)-N,N-dimethylpiperazine-1-carboxamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-hydroxypiperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)-8-(1,2,3,6-tetrahydropyridin-4-yl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(1,1-dioxidethiomorpholino)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-8-(4-hydroxy-4-methylpiperidin-1-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; 8-(3-cyanopiperazin-1-yl)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-methylcyclopropyl)imidazo[1,5-a]pyridine-6-sulfonamide; (R)-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(3-methylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; and (S)-1-chloro-3-(5-(difluoromethyl)-1,3,4-thiadiazol-2-yl)-N-(1-(fluoromethyl)cyclopropyl)-8-(3-methylpiperazin-1-yl)imidazo[1,5-a]pyridine-6-sulfonamide; or a pharmaceutically acceptable salt thereof.

39. 10. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt, hydrate or solvate thereof, and a pharmaceutically acceptable carrier.

40. 40. A compound according to claim 1 or a pharmaceutically acceptable salt, hydrate or solvate thereof, or a pharmaceutical composition according to claim 39, for use in therapy.

41. 41. A compound for use or a pharmaceutical composition for use according to claim 40 for use in a method for treating a disease or disorder in which PARG activity is implicated.

42. 41. A compound for use or a pharmaceutical composition for use according to claim 40 for use in a method for treating a proliferative disorder, preferably wherein said proliferative disorder is cancer, preferably a human cancer.

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