Tablet

Abstract

To provide a tablet that can suppress light-induced fading and discoloration of printed images.SOLUTION: A tablet according to the present embodiment has printed thereon an edible ink that contains at least a colorant selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 and packaged in a water vapor barrier packaging material having a water vapor permeability of not more than 1.0 g / m2 d or less.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to tablets. [Background technology]

[0002] Among dye inks, which are inks containing dyes, there are some that are edible by using food dyes, such as tar-based pigments, as coloring materials. Conventionally, some dye inks have been subject to discoloration, in which the color (tone) of printed characters and images changes, or discoloration due to a decrease in dye saturation, etc., caused by dye degradation. For example, if a dye ink lacks light resistance, discoloration (photodiscoloration) may occur as the dye is decomposed (photodecomposed) by the action of light. Such discoloration is recognized as a decrease in the visibility of printed characters and images (hereinafter collectively referred to as "printed images").

[0003] In order to suppress discoloration of such printed images, technology has been developed, and various methods for suppressing discoloration have been proposed (for example, Patent Document 1). However, some conventional methods cannot sufficiently suppress discoloration due to light in printed images. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Patent No. 6389506 Summary of the Invention [Problem to be solved by the invention]

[0005] The present invention has been made in consideration of these points, and has an object to provide a tablet that can suppress discoloration due to light of a printed image. [Means for solving the problem]

[0006] In order to achieve the above object, the tablet according to one embodiment of the present invention has a water vapor permeability of 1.0 g / m 2The tablet is packaged in a water vapor barrier packaging material having a water vapor barrier property of not more than d and is printed with an edible ink containing at least a coloring material selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3. Effect of the Invention

[0007] According to one aspect of the present invention, a tablet can be provided in which discoloration of a printed image due to light is suppressed. [Brief description of the drawings]

[0008] [Figure 1] FIG. 1 is a schematic cross-sectional view showing an example of a tablet (plain tablet) according to an embodiment of the present invention. [Diagram 2] FIG. 1 is a schematic cross-sectional view showing an example of a tablet (film-coated tablet) according to an embodiment of the present invention. [Diagram 3] 1 is an example of a printed image of a tablet (plain tablet) according to an embodiment of the present invention. [Figure 4] 1 is an example of a printed image of a tablet (film-coated tablet) according to an embodiment of the present invention. [Diagram 5] FIG. 1 is a schematic cross-sectional view showing an example of a layered structure of a water vapor barrier packaging material according to an embodiment of the present invention. [Figure 6] FIG. 1 is a schematic cross-sectional view showing an example of the configuration of a PTP packaging material according to an embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] As a result of extensive research, the present inventors have clarified that humidity contributes to the progression of photodiscoloration of printed images on tablets. As a result, tablets printed with edible ink containing at least a coloring material selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 were placed in a container with a water vapor transmission rate of 1.0 g / m 2 It has been found that by packaging a tablet in a water vapor barrier packaging material having a water vapor barrier strength of 0.1 g / ml or less, it is possible to impart excellent light resistance to the printed image. Based on this, the present inventors have invented a tablet having excellent light resistance.

[0010] In other words, the present disclosure proposes and provides a new design concept for improving the light resistance of printed images on tablets. This point will be described below. In the conventional design concept, in order to improve the lightfastness of a printed image, attention has been focused on the components of the dye ink used to form the printed image, and for example, the combination of pigments and the type of antioxidant have been adjusted. For example, in order to improve lightfastness, measures have been taken such as adding antioxidants (e.g., reduced isomaltulose, lactose, citric acid, etc.) to the dye ink, as well as combining multiple pigments to make the color cloudy in advance.

[0011] Furthermore, dye inks designed based on conventional design concepts often have difficulty in fine-tuning color tones.

[0012] In response to this, the present inventors have focused on the occurrence of differences in the results of lightfastness tests for printed images and have found that humidity affects the test results. In other words, they have newly discovered that in order to improve the lightfastness of printed images, it is important not only to adjust the components of the dye ink, but also to protect the tablets from oxygen and humidity (especially humidity) after printing them until they are used to maintain visibility (suppress light discoloration). As such, the design concept of the present disclosure is significantly different from conventional design concepts that focused only on adjusting the components of the dye ink, and instead focuses on the physical properties of the tablet packaging material as well, and improves the light resistance of the printed images on the tablets by controlling (managing) the tablet storage environment.

[0013] Furthermore, dye inks designed based on the design concepts of the present disclosure make it easy to fine-tune the color tone, and by controlling (managing) the storage environment of the tablets, the light resistance of the printed images on the tablets can be improved.

[0014] The tablet according to this embodiment will be described below. The tablet according to the embodiment of the present invention has a water vapor permeability of 1.0 g / m 2A tablet packaged in a water vapor barrier packaging material having a moisture content of 0.01% or less and having a printed portion printed with an edible ink containing at least a coloring material selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3.

[0015] In addition, the tablet according to the embodiment of the present invention has a water vapor permeability of 1.0 g / m 2 The edible ink contains at least a colorant selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3, a solvent, and an antioxidant, packaged in a water vapor barrier packaging material having a viscosity of d or less, the solvent containing water, ethanol, and propylene glycol, the solvent containing reduced isomaltulose as an antioxidant when Blue No. 1 is included as a colorant, lactose as an antioxidant when Red No. 102 is included as a colorant, potassium citrate as an antioxidant when Red No. 3 is included as a colorant, and does not contain reduced isomaltulose, lactose, or potassium citrate when Yellow No. 4 is included as a colorant, and the content of Blue No. 1 is within the range of 0.01% by mass to 0.90% by mass with respect to the mass of the entire edible ink. the content of reduced isomaltulose is within the range of 2.00% by mass or more and 25.00% by mass or less, relative to the total mass of the edible ink, the content of Red No. 102 is within the range of 0.01% by mass or more and 0.90% by mass or less, relative to the total mass of the edible ink, the content of lactose is within the range of 1.00% by mass or more and 25.00% by mass or less, the content of Red No. 3 is within the range of 0.01% by mass or more and 0.90% by mass or less, relative to the total mass of the edible ink, and the content of potassium citrate is within the range of 0.50% by mass or more and 30.00% by mass or less, relative to the total mass of the edible ink.

[0016] Furthermore, the tablet according to the embodiment of the present invention may be a tablet printed with edible ink containing all of Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 as coloring materials, edible ink containing Blue No. 1 and Red No. 102, edible ink containing Blue No. 1, Yellow No. 4, and Red No. 102, edible ink containing Blue No. 1 and Yellow No. 4, edible ink containing Blue No. 1, Yellow No. 4, and Red No. 3, or edible ink containing Blue No. 1 and Red No. 3. The configuration of the tablet according to the embodiment of the present invention will be described in detail below.

[0017] [Configuration of edible ink] The edible ink according to this embodiment contains at least one coloring material selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3. Each component constituting the edible ink according to this embodiment will be described below.

[0018] (Colorant) As described above, the edible ink according to this embodiment contains at least one of Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 as a coloring material. Blue No. 1 (FDA Name: FD & C Blue No.1, Color Index Name: Food Blue 2, CAS Number: 3844-45-9) is a food dye, specifically a tar-based food coloring, also known as Brilliant Blue FCF.

[0019] In addition, Yellow No. 4 (FDA Name: FD & C Yellow No. 5, Color Index Name: Acid Yellow 23, CAS Number: 1934-21-0) is a food dye, specifically a tar-based food dye, also known as tartrazine.

[0020] In addition, Red No. 102 (Color Index Name: Acid Red 18, CAS Number: 2611-82-7) is a food dye, specifically a tar-based food dye, also known as New Coccine.

[0021] In addition, Red No. 3 (FDA Name: FD&C Red No. 3, Color Index Name: Acid Red 51, CAS Number: 16423-68-0) is a food dye, specifically a tar-based food dye, also known as erythrosine.

[0022] In the edible ink according to the present embodiment, the blending ratio of Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3, i.e., the total content of Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3, is preferably in the range of 0.01% by mass to 10% by mass, more preferably in the range of 0.5% by mass to 10% by mass, based on the total mass of the ink. The total content of Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 may be in the range of 0.01% by mass to 0.09% by mass, based on the total mass of the ink. With this configuration, good visibility is imparted to the printed image, and the occurrence of residual dissolution of the coloring material during the production of the edible ink can be suppressed. Here, for example, after a stirring process of the solvent and the coloring material during the production of the edible ink (for example, a process of adding the coloring material to a solvent at 25° C. and stirring for 60 minutes), if residual dissolution of the coloring material is not visually confirmed, the solubility of the coloring material in the solvent is ensured. Furthermore, with this configuration, fine adjustment of the color tone is also easy.

[0023] On the other hand, if the total content of the coloring materials is less than 0.01% by mass, the overall printed color tends to be lighter and the visibility of the printed image tends to decrease, whereas if the total content exceeds 10% by mass, some of the coloring materials may remain undissolved during the stirring step in the production of the edible ink.

[0024] The edible ink according to the present embodiment may contain a pigment (coloring material) other than the above-mentioned specific tar-based pigment, i.e., Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3. The pigments other than Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 are not particularly limited as long as they are edible. The pigments that can be added to the edible ink according to the present embodiment can be appropriately selected and added from, for example, conventionally known synthetic food pigments and natural food pigments. In addition, when the edible ink contains a coloring material other than Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3, the total content of the coloring material may be within the above range (0.01% by mass or more and 10% by mass or less). This can provide sufficient visibility to the printed image and suppress the occurrence of undissolved coloring material in the edible ink.

[0025] Examples of synthetic food dyes include tar-based dyes, natural dye derivatives, and natural synthetic dyes. Examples of tar-based dyes include Amaranth (FDA Name: FD & C Red No. 2, Color Index Name: Acid Red 27, CAS Number: 915-67-3), Allura Red AC (FDA Name: FD & C Red No. 40, Color Index Name: Food Red 40, CAS Number: 25956-17-6), Phloxine (FDA Name: D&C Red No. 28, Color Index Name: Acid Red 92, CAS Number: 18472-87-2), Rose bengal (FDA Name: Acid Red 94, CAS Number: 632-69-9), and Acid Red (FDA Name: Acid Red 52, CAS Number: 3520-42-1), Sunset Yellow FCF, FDA Name: FD & C Yellow No.6, Color Index Name: Food Yellow 3, CAS Number: 2783-94-0, Indigo Carmine, FDA Name: FD & C Blue No.2, Color Index Name: Acid Blue 74, CAS Number: 860-22-0, FD & C Red No.2 Aluminum Lake, FD & C Red No.3 Aluminum Lake, FD & C Red No.40 Aluminum Lake, FD & C Yellow No.5 Aluminum Lake, FD & C Yellow No.6 Aluminum Lake, FD & C Blue No.1 Aluminum LakeFD & C Blue No. 1 Aluminum Lake, and FD & C Blue No. 2 Aluminum Lake.

[0026] An example of a natural pigment derivative is potassium norbixin, etc. An example of a natural synthetic pigment is β-carotene, riboflavin, etc.

[0027] The above-mentioned "Color Index Name" is established by the American Association of Textile Chemists and Colorists. The above-mentioned "FDA Name" is established by the US FDA (Food and Drug Administration). In this embodiment, each usable dye (each substance) is specified using a CAS Number, but the present invention is not limited to this. For example, a dye (substance) having the same substance name as the dye (substance) described in this embodiment but a different CAS Number can be used in this embodiment because it is a geometric isomer, a stereoisomer, a substance containing an isotope, or a salt thereof. In addition, when there is no isomer or the usable dye (substance) is specified (limited), the substance (compound) itself with the CAS Number described in this embodiment can be used.

[0028] Examples of natural food dyes include anthocyanin dyes, carotenoid dyes, quinone dyes, chlorophyll dyes, flavonoid dyes, betaine dyes, monascus dyes, and other dyes derived from natural products. Examples of anthocyanin dyes include red radish dyes, red cabbage dyes, red rice dyes, elderberry dyes, cowberry dyes, gooseberry dyes, cranberry dyes, salmonberry dyes, perilla dyes, sweet blueberry dyes, strawberry dyes, dark sweet cherry dyes, cherry dyes, hibiscus dyes, huckleberry dyes, grape juice dyes, grape skin dyes, blackcurrant dyes, blackberry dyes, blueberry dyes, plum dyes, white wortberry dyes, boysenberry dyes, mulberry dyes, purple sweet potato dyes, purple corn dyes, purple yam dyes, raspberry dyes, redcurrant dyes, loganberry dyes, and other anthocyanin dyes. Examples of carotenoid pigments include annatto pigment, gardenia yellow, and other carotenoid pigments. Examples of quinone pigments include cochineal pigment, lithospermum pigment, lac pigment, and other quinone pigments. Examples of flavonoid pigments include safflower yellow, sorghum pigment, onion pigment, and other flavonoid pigments. Examples of betaine pigments include beet red pigment. Examples of monascus pigments include red koji pigment and red koji yellow. Examples of pigments derived from other natural products include turmeric pigment, clover pigment, gardenia red pigment, spirulina blue pigment, and the like.

[0029] (Antioxidant) The edible ink according to this embodiment may contain reduced isomaltulose, lactose, or potassium citrate as an antioxidant (reducing agent). For example, reduced isomaltulose functions as a discoloration inhibitor for Blue No. 1 and has the effect of suppressing photodecomposition of Blue No. 1. Therefore, when the edible ink according to this embodiment contains Blue No. 1 as a coloring material, the edible ink preferably contains reduced isomaltulose as an antioxidant.

[0030] Furthermore, lactose functions as a discoloration inhibitor for Red No. 102 and has the effect of suppressing photodecomposition of Red No. 102. Therefore, when the edible ink according to this embodiment contains Red No. 102 as a coloring material, the edible ink preferably contains lactose as an antioxidant.

[0031] Furthermore, potassium citric acid functions as a discoloration inhibitor for Red No. 3 and has the effect of suppressing photodecomposition of Red No. 3. Therefore, when the edible ink according to this embodiment contains Red No. 3 as a coloring material, the edible ink preferably contains potassium citric acid as an antioxidant. In addition, when the edible ink according to this embodiment contains only Yellow No. 4 as a coloring material, the edible ink does not need to contain an antioxidant.

[0032] By adding the above antioxidants, the edible inks containing Blue No. 1, Red No. 102, and Red No. 3 of this embodiment can maintain the initial printed color (the color immediately after printing) while sufficiently suppressing photodiscoloration and fading of the printed image, thereby improving light resistance.

[0033] Furthermore, the edible ink containing Yellow No. 4 according to this embodiment can improve light resistance by sufficiently suppressing photodiscoloration and fading of the printed image while retaining the initial print color (the color immediately after printing) without the addition of an antioxidant. In addition, when the edible ink according to this embodiment contains all of Blue No. 1, Red No. 102, and Red No. 3 as coloring materials, it may also contain all of reduced isomaltulose, lactose, and potassium citrate.

[0034] The blending ratio of the antioxidants (reduced isomaltulose, lactose, potassium citrate) in the edible ink according to this embodiment, i.e., the total content of the antioxidants, is preferably in the range of 0.01% by mass to 30% by mass, more preferably in the range of 0.5% by mass to 30% by mass, based on the total mass of the ink. With this configuration, the effect of the antioxidants as a discoloration inhibitor is more reliably exhibited, the lightfastness of the edible ink according to this embodiment is reliably improved, and the deterioration of the ejection properties due to an increase in the viscosity of the ink can be prevented. Furthermore, with this configuration, fine adjustment of the color tone is also easy.

[0035] For example, in the edible ink according to the present embodiment, when the content of Blue No. 1 is within the range of 0.01% by mass to 0.90% by mass of the entire edible ink, the content of reduced isomaltulose may be within the range of 2.00% by mass to 25.00% by mass of the entire edible ink, when the content of Red No. 102 is within the range of 0.01% by mass to 0.90% by mass of the entire edible ink, the content of lactose may be within the range of 1.00% by mass to 25.00% by mass of the entire edible ink, and when the content of Red No. 3 is within the range of 0.01% by mass to 0.90% by mass of the entire edible ink, the content of potassium citrate may be within the range of 0.50% by mass to 30.00% by mass of the entire edible ink. With such a configuration, it is easy to fine-tune the color tone.

[0036] On the other hand, if the blending ratio of the antioxidant is less than 0.01% by mass, the effect of the antioxidant as an agent for suppressing discoloration of the ink may be reduced, and if the blending ratio of the antioxidant is more than 30% by mass, the ink viscosity may increase, resulting in a deterioration in the ejection properties.

[0037] (solvent) The edible ink according to the present embodiment may contain a solvent (dispersion medium) to dissolve (disperse) the specific tar-based pigments (Blue No. 1, Yellow No. 4, Red No. 102, Red No. 3) and the antioxidants (reduced isomaltulose, lactose, potassium citrate) contained as discoloration inhibitors. The edible ink according to the present embodiment preferably contains at least one of water (e.g., purified water), ethanol, and propylene glycol as a solvent. Propylene glycol functions as a humectant, and can prevent the ink from drying in, for example, an inkjet nozzle, thereby imparting sufficient intermittent restartability to the ink. In addition, ethanol is highly volatile, and can improve the transfer resistance (drying property) of the edible ink. By adding these components to the solvent in addition to water, the edible ink can be imparted with performance according to each component.

[0038] In addition, although the blending ratio of each component of the above-mentioned solvent in the edible ink according to this embodiment is not limited, when the solvent contains propylene glycol, the blending ratio of the propylene glycol, i.e., the amount of propylene glycol added, may be within a range of 0.01% by mass to 40% by mass with respect to the total mass of the ink. With such a configuration, it is possible to impart sufficient intermittent restartability to the ink.

[0039] Furthermore, when the solvent contains ethanol, the blending ratio of the ethanol, i.e., the amount of ethanol added, may be within a range of 1% by mass to 60% by mass with respect to the total mass of the ink. With this configuration, the transfer resistance (drying property) of the edible ink can be improved.

[0040] The edible ink according to this embodiment may contain solvents other than those mentioned above. Examples of solvents that can be added to the edible ink according to this embodiment include glycerin, polyethylene glycol 300 (average molecular weight 300), 1-propanol, 2-propanol, and ethyl lactate. Although there are no particular limitations on the blending ratio, either glycerin or polyethylene glycol 300 may be contained in the ink in a range of 1% by mass to 40% by mass in order to prevent the ink from drying at the nozzle.

[0041] (Lightfastness) Hereinafter, the light resistance of the tablet according to this embodiment will be described in detail. In the tablet according to the present embodiment, the color difference ΔE according to JIS Z 8781 before and after the light fastness test of the printed image is preferably within 20, more preferably within 10. Here, the light fastness test is, for example, a test to compare the color difference ΔE (compliant with JIS Z 8781) indicating the amount of change in chromaticity and optical color density before and after irradiation with visible light for a printed image printed using the edible ink according to the present embodiment. Specifically, the color difference ΔE is measured before and after irradiation with visible light of a cumulative 1.2 million lux (illuminance 4 klx × 300 hours) on the printed image, and the values ​​are compared. For example, a xenon weather meter (D65 light source: Toyo Seiki Co., Ltd. Ci4000) is used for the irradiation of visible light. Note that the irradiation of visible light in the present embodiment is performed under an environment with an average temperature of 27.2 ° C. and an average humidity of 49.9%, and a water vapor transmission rate of 1.0 g / m 2 This test is performed on tablets packaged in water vapor barrier packaging material (light transmittance 90%) with a value of d or less.

[0042] The printed image in the light resistance test is, for example, a solid print on a tablet (for example, a film-coated tablet) which is the printing target.

[0043] The lightfastness required for forming a printed image on a medical tablet or the like (lightfastness required for practical use of a medical tablet or the like) often refers to a color difference ΔE of a printed image before and after irradiation with visible light of 1.2 million lux in a lightfastness test. The inventors derived a color difference ΔE of 15 or less as the criterion for practical lightfastness based on the results of an opinion test conducted by the inventors with the participation of various medical professionals. However, in the edible ink according to the present embodiment, since the color tone is clear by using Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 as coloring materials, if the color difference ΔE is 20 or less, the ink is deemed to have sufficient lightfastness and is considered to pass this evaluation.

[0044] The edible ink according to the present embodiment contains Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 as coloring materials, and a tablet having an image printed with the edible ink is coated with an edible ink having a water vapor permeability of 1.0 g / m 2 By packaging the tablets in a water vapor barrier packaging material with a water vapor barrier property of 0.1-d or less, the photodecomposition of Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 on the tablet surface is suppressed, and photodiscoloration and photofading of the printed image are sufficiently suppressed. As a result, the color difference ΔE before and after irradiation with visible light is reduced to less than 20, and the visibility of the printed image is maintained.

[0045] (Internal resin) The edible ink according to the present embodiment may contain an internal resin in addition to the above-mentioned dyes and solvents. The internal resin that can be added to the edible ink according to the present embodiment may be a water-soluble powder, paste, or flake-like resin-like substance that is edible and capable of forming a film on the tablet surface by drying after printing. Examples of the internal resin include polyvinyl alcohol (PVA), hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), polyvinylpyrrolidone (PVP), high molecular weight polyethylene glycol (PEG) such as polyethylene glycol 4000 / polyethylene glycol 1540, shellac resin, methacrylic acid copolymer (product name: Eudragit S100), maltodextrin, erythritol, and the like.

[0046] (Leveling agent) The edible ink according to the present embodiment may contain a leveling agent in addition to the above-mentioned dyes, solvents, or internally added resins. The leveling agent that can be added to the edible ink according to the present embodiment may be any surfactant that is edible and water-soluble. Examples of the leveling agent include polyglycerin fatty acid esters (e.g., Decaglycerin Distearate Q-182S, Decaglycerin Monolaurate Q-12S, Taiyo Kagaku Co., Ltd.), sorbitan fatty acid esters (e.g., NIKKOL SL-10, Nikko Chemicals Co., Ltd.), sucrose fatty acid esters (e.g., DK Ester F-110, Daiichi Kogyo Seiyaku Co., Ltd.), polysorbates (Emersol S-120 series, Kao Corporation), and the like.

[0047] [Printing method] The printing method of the edible ink according to this embodiment is not particularly limited, and it is possible to print using an inkjet device such as a commercially available inkjet printer. Therefore, the edible ink according to this embodiment has a wide range of applications and is very useful. For example, the edible ink according to this embodiment can be printed using a so-called drop-on-demand type inkjet device that uses a piezoelectric element (piezoelectric ceramics) as an actuator, and can also be printed using other types of inkjet devices.

[0048] Examples of drop-on-demand inkjet devices include devices that use a thermal inkjet method in which ink is ejected by the steam pressure generated by momentarily heating a micro-heating element to a high temperature (200 to 300°C), electrostatic type devices that eject ink by electrostatically vibrating an actuator, and devices that use an ultrasonic method that utilizes the cavitation phenomenon of ultrasonic waves. In addition, if the edible ink according to this embodiment has charging properties, it is also possible to use a device that uses a continuous ejection method.

[0049] 〔tablet〕 In this embodiment, the edible ink according to this embodiment may be printed or printed on the surface of a tablet, for example, using the printing method described above. In other words, the tablet according to this embodiment may have a printed portion, i.e., a printed image, printed using the edible ink according to this embodiment. The edible ink according to this embodiment can improve the light resistance of a printed image (e.g., printed image 3) applied to the surface of a medical tablet using an inkjet printing method, for example. The configuration of a tablet having a printed image printed with the edible ink according to this embodiment will be described below.

[0050] The tablet according to the present embodiment is, for example, a medical tablet. Here, the term "medical tablet" refers to, for example, plain tablets (plain tablets), sugar-coated tablets, enteric tablets, orally disintegrating tablets, as well as film-coated tablets in which a water-soluble surface layer is formed on the outermost surface of the tablet. The tablet according to the present embodiment is not limited to these examples.

[0051] Fig. 1 is a schematic cross-sectional view showing an example of a medical tablet (plain tablet) on which printing (printing, image printing) has been performed. Fig. 1 shows, in cross-sectional view, a plain tablet print 5 in which a printed image 3 such as letters is printed on the upper surface of a base material 1 of the tablet.

[0052] Fig. 2 is a schematic cross-sectional view showing an example of a medical tablet (film-coated (FC) tablet) on which printing (printing of characters, images) has been performed. Fig. 2 shows, in cross-sectional view, a film-coated tablet print 9 in which a printed image 3 such as letters is printed on the upper surface of a substrate 1 of a tablet having a film-coated layer 7 formed on the surface. In this embodiment, as shown in FIG. 3, a solid image may be printed as the plain tablet printed image 11, and as shown in FIG. 4, a two-dimensional barcode may be printed as the film-coated tablet printed image 13.

[0053] The active ingredient contained in the medical tablet is not particularly limited, and includes, for example, substances effective for the prevention and treatment of various diseases (e.g., substances having sleep-inducing action, tranquilizing activity, antibacterial activity, antihypertensive action, antianginal activity, analgesic action, anti-inflammatory activity, tranquilizing action, antidiabetic activity, diuretic action, anticholinergic activity, anti-gastric hyperacidity action, anti-epileptic action, ACE inhibitory activity, β-receptor antagonist or agonist activity, anesthetic action, appetite suppressant action, antiarrhythmic action, antidepressant action, anticoagulant activity, antidiarrheal action, antihistamine activity, antimalarial action, antitumor activity, immunosuppressant activity, antiparkinsonian action, antipsychotic action, antiplatelet activity, antihyperlipidemic action, etc.), substances having a cleaning action, fragrances, substances having a deodorant action, etc., but are not limited thereto.

[0054] The tablet according to the present embodiment can be mixed with a carrier acceptable for its use together with the active ingredient as necessary. For example, if it is a medical tablet, a medicament acceptable carrier can be mixed. As the medicament acceptable carrier, various organic or inorganic carrier substances commonly used as pharmaceutical materials are used, and for example, excipients, lubricants, binders, disintegrants, thickeners, etc. are appropriately mixed in appropriate amounts. In addition, additives such as preservatives, antioxidants, colorants, and sweeteners can be used as necessary.

[0055] In this embodiment, medical tablets are used as an example of tablets, but the present invention is not limited to this. The printing target of the edible ink according to this embodiment is not particularly limited, and may be printed on the surface of various tablets such as tablets administered to animals other than humans (pets, livestock, poultry, etc.), feed, fertilizer, cleaning agent, tablet candy such as Ramune candy, and food such as supplements. In addition, the edible ink according to this embodiment is not particularly limited in size of the printing target, and can be applied to tablets of various sizes.

[0056] [Packaging material] In this embodiment, a tablet printed with an edible ink containing at least a coloring material selected from the above-mentioned Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 is used as a food additive having a water vapor permeability of 1.0 g / m 2Packaging is done using water vapor barrier packaging material with a value of d or less. The barrier packaging material has a water vapor permeability of 1.0 g / m 2 ·d or less, and a barrier PTP (press-through package) packaging material with a water vapor permeability of 0.5 g / m 2 d or less, and the oxygen permeability is 3.0 cm 3 / m 2 It is even more preferable that the barrier PTP packaging material has a thickness of .d or less.

[0057] Moreover, the barrier packaging material has a light transmittance (transparency) that transmits 90% or more of the light from the light source used in the light resistance test.

[0058] In this embodiment, as long as the light transmittance (transparency) and water vapor permeability have the above-mentioned physical properties, the type of packaging material is not particularly limited. For example, a packaging material that can be used in this embodiment is a water vapor barrier packaging material using a multilayer sheet described in JP 2022-47772 A. This water vapor barrier packaging material is a film in which a polyglycolic acid (PGA) resin is used as a barrier layer and polypropylene (PP) resin or LDPE (low density polyethylene) resin is laminated on both sides of the barrier layer. More specifically, the packaging material may be a multilayer sheet formed by forming a film of a PGA resin, an adhesive resin, and a PP resin or an LDPE resin using a multilayer extruder, or may be a multilayer sheet 20 produced by laminating an oxygen gas barrier substrate 23 made of a PGA film and sealant layers 21 and 25 made of a PP film or an LDPE film via water vapor barrier adhesive layers 22 and 24, as shown in FIG. 5. In the case of the multi-layer sheet 20, the water vapor permeability is 0.25 g / m 2 d, and the oxygen permeability is 0.66 cm 3 / m 2 Furthermore, the multilayer sheet 20 has a light transmittance of about 90%.

[0059] In this embodiment, the shape of the packaging material is not particularly limited as long as the light transmittance (transparency) and water vapor permeability are as described above. The shape of the packaging material may be, for example, a PTP (press-through package) packaging material as shown in FIG. In the PTP packaging material shown in FIG. 6, the tablet according to this embodiment is stored in a storage portion 28 located between a sealing member 26 and a base material 27. The water vapor permeability specified in this embodiment is a value measured in accordance with JIS Z0208.

[0060] The oxygen permeability specified in this embodiment is a value measured in accordance with JIS K7126. The light transmittance specified in this embodiment is a value measured in accordance with JIS K7361-1.

[0061] [Tablet storage method (preservation method)] In this embodiment, a tablet having a print portion printed with an edible ink containing at least a coloring material selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 is prepared by subjecting the tablet to a water vapor transmission rate of 1.0 g / m 2The edible ink may be stored (preserved) in a water vapor barrier packaging material having a water vapor barrier viscosity of 0.01% or less by mass, and the ... The content of Red No. 102 is within the range of 0.01% by mass to 0.90% by mass with respect to the total mass of the edible ink, the content of lactose is within the range of 1.00% by mass to 25.00% by mass with respect to the total mass of the edible ink, the content of Red No. 3 is within the range of 0.01% by mass to 0.90% by mass with respect to the total mass of the edible ink, and the content of potassium citrate is within the range of 0.50% by mass to 30.00% by mass with respect to the total mass of the edible ink, 2 It may be stored (preserved) by packaging it in a water vapor barrier packaging material with a water vapor barrier property of d or less.

[0062] In the present embodiment, a tablet having a printed portion printed with edible ink containing all of Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 as a coloring material, edible ink containing Blue No. 1 and Red No. 102, edible ink containing Blue No. 1, Yellow No. 4, and Red No. 102, edible ink containing Blue No. 1 and Yellow No. 4, edible ink containing Blue No. 1, Yellow No. 4, and Red No. 3, or edible ink containing Blue No. 1 and Red No. 3, is used as a coloring material. The tablet has a water vapor transmission rate of 1.0 g / m 2 It may be stored (preserved) by packaging it in a water vapor barrier packaging material with a water vapor barrier property of d or less. The barrier packaging material has a water vapor permeability of 1.0 g / m 2·d or less, and a barrier PTP (press-through package) packaging material with a water vapor permeability of 0.5 g / m 2 d or less, and the oxygen permeability is 3.0 cm 3 / m 2 It is even more preferable that the barrier PTP packaging material has a thickness of .d or less.

[0063] (Effects of this embodiment) (1) The tablet according to this embodiment has a water vapor permeability of 1.0 g / m 2 The tablet is packaged in a water vapor barrier packaging material having a water vapor barrier property of not more than d and is printed with an edible ink containing at least a coloring material selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3. With this configuration, exposure to water vapor can be reduced compared to conventional techniques, and photodiscoloration and photofading of printed images can be sufficiently suppressed.

[0064] (2) The edible ink used to form the printed image of the tablet in this embodiment preferably further contains an antioxidant, and when it contains Blue No. 1 as a coloring material, it contains reduced isomaltulose as an antioxidant, when it contains Red No. 102 as a coloring material, it contains lactose as an antioxidant, and when it contains Red No. 3 as a coloring material, it preferably contains potassium citrate as an antioxidant. With this configuration, oxidation of the coloring material can be suppressed, and photodiscoloration and photofading of the printed image can be sufficiently suppressed, compared to the prior art.

[0065] (3) In addition, the tablet according to this embodiment has a water vapor permeability of 1.0 g / m 2 It is preferable that the material is packaged in a barrier PTP packaging material with a value of .d or less. With this configuration, exposure to water vapor can be reduced compared to conventional technology, photodiscoloration and fading of printed images can be sufficiently suppressed, and packaged tablets can be easily removed.

[0066] (4) In addition, the tablet according to this embodiment has a water vapor permeability of 0.5 g / m 2 d or less, and the oxygen permeability is 3.0 cm 3 / m 2 It is preferable that the material is packaged in a barrier PTP packaging material with a value of .d or less. With this configuration, exposure to water vapor can be further reduced compared to conventional techniques, and exposure to oxygen can also be reduced, thereby sufficiently suppressing photodiscoloration and fading of printed images.

[0067] (5) Moreover, the tablet according to the present embodiment preferably has a color difference ΔE of 20 or less before and after a light fastness test of a printed image according to JIS Z 8781. With this configuration, photodiscoloration and photofading of the printed image can be reliably suppressed compared to the prior art.

[0068] (6) In addition, the method for storing (preserving) the tablet according to the present embodiment is to store the tablet in a container having a water vapor permeability of 1.0 g / m, the container having a print portion printed with an edible ink containing at least a coloring material selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3, and the container having a water vapor permeability of 1.0 g / m 2 This is a method of packaging and storing the material in a water vapor barrier material with a water vapor barrier property of less than 1. With this configuration, exposure to water vapor can be reduced compared to conventional techniques, and photodiscoloration and photofading of printed images can be sufficiently suppressed.

[0069] [Example] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples in any way.

[0070] (First embodiment) <Example 1-1> The procedure for preparing the edible ink according to Example 1-1 will be described below. (Manufacturing edible ink) First, the printing ink was prepared. The edible ink contains at least each component of a pigment (coloring material) and a solvent. The preparation procedure was as follows: first, water, propylene glycol, and ethanol were mixed to obtain a mixed solvent. Next, the coloring material was added to the mixed solvent at 25°C and stirred for a certain period of time (for example, 60 minutes). In this way, the ink according to this embodiment was prepared. The various components will be specifically described below.

[0071] In this example, the food dye Blue No. 1 was added as a coloring material to the above-mentioned solvent, and the mixture was stirred for about 1 hour to obtain the edible ink of Example 1-1. The blending ratio of the coloring material Blue No. 1 to the entire edible ink of Example 1-1 was 1.5 mass%, the blending ratio of purified water in the solvent was 64.00 mass%, the blending ratio of propylene glycol was 28.0 mass%, and the blending ratio of ethanol was 6.5 mass%.

[0072] Next, the edible ink of Example 1-1 was passed through a membrane filter to remove solid foreign matter in the liquid. Specifically, the ink was passed once through a membrane filter (cellulose acetate membrane) with a diameter of 5.0 μm, and then once through a membrane filter (cellulose acetate membrane) with a diameter of 0.8 μm to obtain a purified ink. The tablet having the image printed with the edible ink (refined ink) thus obtained was subjected to a water vapor transmission rate of 0.25 g / m 2 d and the oxygen permeability is 0.66 cm 3 / m 2 The product was packaged in a barrier PTP packaging material. In this example, the refined edible ink was printed on a tablet in a room temperature and humidity environment, and then hot air at 40° C. was blown for 10 seconds using a continuous drying mechanism to obtain a printed image.

[0073] <Example 1-2> The edible ink of Example 1-2 was obtained in the same manner as in Example 1-1, except that the food dye Yellow No. 4 was added as a coloring material. Furthermore, tablets having an image printed with the edible ink thus obtained were packaged in the same barrier PTP packaging material as in Example 1-1. <Example 1-3> The edible ink of Example 1-3 was obtained in the same manner as in Example 1-1, except that the food dye Red No. 102 was added as a coloring material. Furthermore, tablets having an image printed with the edible ink thus obtained were packaged in the same barrier PTP packaging material as in Example 1-1.

[0074] <Example 1-4> The edible ink of Example 1-4 was obtained in the same manner as in Example 1-1, except that the food dye Red No. 3 was added as a coloring material. Furthermore, tablets having an image printed with the edible ink thus obtained were packaged in the same barrier PTP packaging material as in Example 1-1. <Example 1-5> The tablet having the printed image printed with the edible ink of Example 1-1 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0075] <Examples 1-6> The tablets having the images printed with the edible ink of Example 1-2 were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-7> The tablets having the images printed with the edible ink of Example 1-3 were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-8> The tablets having the images printed with the edible ink of Example 1-4 were packaged in the same barrier PTP packaging material as in Example 1-5.

[0076] <Example 1-9> The edible ink according to this embodiment contains the following components: pigment (coloring material), solvent, and antioxidant (reducing agent). The preparation process was as follows: first, reduced isomaltulose, an antioxidant, was added to the solvent to obtain a transparent base liquid. Next, an edible dye was added to the transparent base liquid. In this manner, the ink according to this embodiment was prepared. The various components will be specifically described below. In this example, the edible dye Blue No. 1 was added as a coloring material to the transparent base liquid, and the mixture was stirred for about 1 hour to obtain the edible ink of Example 1-9. The blending ratio of the coloring material Blue No. 1 was 1.5% by mass, the blending ratio of purified water among the solvents was 52.50% by mass, the blending ratio of propylene glycol was 28.0% by mass, and the blending ratio of ethanol was 6.5% by mass, relative to the entire edible ink of Example 1-9. In addition, the blending ratio of reduced isomaltulose as an antioxidant was 11.5% by mass. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-1.

[0077] <Example 1-10> The edible ink of Example 1-10 was obtained in the same manner as in Example 1-9, except that the food dye Red No. 102 was added as a coloring material and lactose was added as an antioxidant. In this example, the blending ratio of purified water was 60.50 mass% and the blending ratio of lactose was 3.50 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-1. <Example 1-11> The edible ink of Example 1-11 was obtained in the same manner as Example 1-9, except that the food dye Red No. 3 was added as a coloring material and potassium citrate was added as an antioxidant. In this example, the blending ratio of purified water was 62.50 mass% and the blending ratio of potassium citrate was 1.50 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-1.

[0078] <Example 1-12> The tablets having the images printed with the edible ink of Example 1-9 were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-13> The tablets having the images printed with the edible ink of Example 1-10 were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-14> The tablets having the images printed with the edible ink of Example 1-11 were packaged in the same barrier PTP packaging material as in Example 1-5.

[0079] <Example 1-15> The edible ink of Example 1-15 was obtained in the same manner as Example 1-9, except that the blending ratio of Blue No. 1 was 0.50 mass%, the blending ratio of purified water was 63.00 mass%, and the blending ratio of reduced isomaltulose was 2.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-16> An edible ink of Example 1-16 was obtained in the same manner as in Example 1-15, except that the blending ratio of purified water was 40.00 mass % and the blending ratio of reduced isomaltulose was 25.00 mass %. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0080] <Example 1-17> The edible ink of Example 1-17 was obtained in the same manner as Example 1-15, except that the blending ratio of Blue No. 1 was 1.00 mass%, the blending ratio of purified water was 56.50 mass%, and the blending ratio of reduced isomaltulose was 8.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-18> The edible ink of Example 1-18 was obtained in the same manner as Example 1-15, except that the blending ratio of Blue No. 1 was 1.00 mass%, the blending ratio of purified water was 49.50 mass%, and the blending ratio of reduced isomaltulose was 15.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0081] <Example 1-19> The edible ink of Example 1-19 was obtained in the same manner as Example 1-15, except that the blending ratio of Blue No. 1 was 5.00 mass%, the blending ratio of purified water was 52.50 mass%, and the blending ratio of reduced isomaltulose was 8.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-20> The edible ink of Example 1-20 was obtained in the same manner as Example 1-15, except that the blending ratio of Blue No. 1 was 5.00 mass%, the blending ratio of purified water was 45.50 mass%, and the blending ratio of reduced isomaltulose was 15.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0082] <Example 1-21> The edible ink of Example 1-21 was obtained in the same manner as Example 1-15, except that the blending ratio of Blue No. 1 was 10.00 mass%, the blending ratio of purified water was 53.50 mass%, and the blending ratio of reduced isomaltulose was 2.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-22> The edible ink of Example 1-22 was obtained in the same manner as Example 1-15, except that the blending ratio of Blue No. 1 was 10.00 mass%, the blending ratio of purified water was 30.50 mass%, and the blending ratio of reduced isomaltulose was 25.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0083] <Example 1-23> An edible ink of Example 1-23 was obtained in the same manner as in Example 1-6, except that the blending ratio of Yellow No. 4 was 0.50 mass % and the blending ratio of purified water was 65.00 mass %. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-24> An edible ink of Example 1-24 was obtained in the same manner as in Example 1-6, except that the blending ratio of Yellow No. 4 was 1.00 mass % and the blending ratio of purified water was 64.50 mass %. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0084] <Example 1-25> An edible ink of Example 1-25 was obtained in the same manner as in Example 1-6, except that the blending ratio of Yellow No. 4 was 5.00 mass % and the blending ratio of purified water was 60.50 mass %. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-26> An edible ink of Example 1-26 was obtained in the same manner as in Example 1-6, except that the blending ratio of Yellow No. 4 was 10.00 mass % and the blending ratio of purified water was 55.50 mass %. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0085] <Example 1-27> The edible ink of Example 1-27 was obtained in the same manner as Example 1-10, except that the blending ratio of Red No. 102 was 0.50 mass%, the blending ratio of purified water was 64.00 mass%, and the blending ratio of lactose was 1.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-28> The edible ink of Example 1-28 was obtained in the same manner as Example 1-10, except that the blending ratio of Red No. 102 was 0.50 mass%, the blending ratio of purified water was 40.00 mass%, and the blending ratio of lactose was 25.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0086] <Example 1-29> The edible ink of Example 1-29 was obtained in the same manner as Example 1-10, except that the blending ratio of Red No. 102 was 1.00 mass%, the blending ratio of purified water was 62.50 mass%, and the blending ratio of lactose was 2.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-30> The edible ink of Example 1-30 was obtained in the same manner as Example 1-10, except that the blending ratio of Red No. 102 was 1.00 mass%, the blending ratio of purified water was 54.50 mass%, and the blending ratio of lactose was 10.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0087] <Example 1-31> The edible ink of Example 1-31 was obtained in the same manner as Example 1-10, except that the blending ratio of Red No. 102 was 5.00 mass%, the blending ratio of purified water was 58.50 mass%, and the blending ratio of lactose was 2.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-32> The edible ink of Example 1-32 was obtained in the same manner as Example 1-10, except that the blending ratio of Red No. 102 was 5.00 mass%, the blending ratio of purified water was 50.50 mass%, and the blending ratio of lactose was 10.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0088] <Example 1-33> The edible ink of Example 1-33 was obtained in the same manner as Example 1-10, except that the blending ratio of Red No. 102 was 10.00 mass%, the blending ratio of purified water was 54.50 mass%, and the blending ratio of lactose was 1.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-34> The edible ink of Example 1-34 was obtained in the same manner as Example 1-10, except that the blending ratio of Red No. 102 was 10.00 mass%, the blending ratio of purified water was 30.50 mass%, and the blending ratio of lactose was 25.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0089] <Example 1-35> The edible ink of Example 1-35 was obtained in the same manner as Example 1-11, except that the blending ratio of Red No. 3 was 0.50 mass%, the blending ratio of purified water was 64.50 mass%, and the blending ratio of potassium citrate was 0.50 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-36> The edible ink of Example 1-36 was obtained in the same manner as Example 1-11, except that the blending ratio of Red No. 3 was 0.50 mass%, the blending ratio of purified water was 35.00 mass%, and the blending ratio of potassium citrate was 30.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0090] <Example 1-37> The edible ink of Example 1-37 was obtained in the same manner as Example 1-11, except that the blending ratio of Red No. 3 was 1.00 mass%, the blending ratio of purified water was 63.00 mass%, and the blending ratio of potassium citrate was 1.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-38> The edible ink of Example 1-38 was obtained in the same manner as Example 1-11, except that the blending ratio of Red No. 3 was 1.00 mass%, the blending ratio of purified water was 54.50 mass%, and the blending ratio of potassium citrate was 10.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0091] <Example 1-39> The edible ink of Example 1-39 was obtained in the same manner as Example 1-11, except that the blending ratio of Red No. 3 was 5.00 mass%, the blending ratio of purified water was 60.00 mass%, and the blending ratio of potassium citrate was 0.50 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-40> The edible ink of Example 1-40 was obtained in the same manner as Example 1-11, except that the blending ratio of Red No. 3 was 5.00 mass%, the blending ratio of purified water was 50.50 mass%, and the blending ratio of potassium citrate was 10.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0092] <Example 1-41> The edible ink of Example 1-41 was obtained in the same manner as Example 1-11, except that the blending ratio of Red No. 3 was 10.00 mass%, the blending ratio of purified water was 55.00 mass%, and the blending ratio of potassium citrate was 0.50 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5. <Example 1-42> The edible ink of Example 1-42 was obtained in the same manner as Example 1-11, except that the blending ratio of Red No. 3 was 10.00 mass%, the blending ratio of purified water was 45.00 mass%, and the blending ratio of potassium citrate was 10.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 1-5.

[0093] <Comparative Example 1-1> The tablet having the image printed with the edible ink of Example 1-1 was subjected to a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471"). <Comparative Example 1-2> The tablets having the images printed with the edible ink of Example 1-2 were packaged in the same barrier PTP packaging material as in Comparative Example 1-1. <Comparative Example 1-3> The tablets having the images printed with the edible ink of Example 1-3 were packaged in the same barrier PTP packaging material as in Comparative Example 1-1. <Comparative Example 1-4> The tablets having the images printed with the edible ink of Example 1-4 were packaged in the same barrier PTP packaging material as in Comparative Example 1-1.

[0094] <Comparative Example 1-5> The tablets with the printed image printed with the edible ink of Example 1-1 were not packaged. <Comparative Example 1-6> The tablets with the printed image printed with the edible ink of Example 1-2 were not packaged. <Comparative Example 1-7> The tablets with the printed images printed with the edible ink of Examples 1-3 were not packaged. <Comparative Example 1-8> The tablets with the printed images printed with the edible ink of Examples 1-4 were not packaged.

[0095] <Evaluation> The print density and light resistance of the images printed with the inks of the above Examples and Comparative Examples were evaluated by the following methods. The intermittent restartability of the inks of the above Examples and Comparative Examples was also evaluated by the following methods. The evaluation results are shown in Tables 1 to 4.

[0096] (Print density and light resistance test) Using a piezoelectric ceramic-driven drop-on-demand inkjet head with a printing resolution of 600 dpi in the main scanning direction, 600 dpi in the sub-scanning direction (the direction in which the recording medium such as tablets is transported), and a total of 2,656 nozzles, images were printed on the tablets listed below using the refined inks of Examples 1-1 to 1-42 and Comparative Examples 1-1 to 1-8 above at a printing drop volume of 6 pl per drop. The tablets to be printed were test plain tablets (base: adjusted starch, diameter: 6.5 mm) and test film-coated tablets (base: adjusted starch, coating agent: mixture of 70% hydroxypropyl methylcellulose and 30% titanium oxide, diameter: 6.5 mm). The printed image was a circular solid image (diameter 4.0 mm). In this way, plain tablet prints and film-coated tablet prints were obtained.

[0097] The plain tablet prints and the film-coated tablet prints of each Example and Comparative Example, in which the chromaticity and optical color density (print density) were measured, were irradiated with a cumulative visible light of 1.2 million lux using a xenon weather meter (Toyo Seiki Co., Ltd. Ci4000) while packaged in a packaging material. The plain tablet prints and the film-coated tablet prints irradiated with visible light were measured with a spectrophotometer to measure the chromaticity and optical color density, and the color difference ΔE (based on JIS Z 8781), which indicates the amount of change in chromaticity and optical color density before and after irradiation with visible light, was compared. The results of the comparison are shown in Tables 1 to 4. As described above, regarding the change in color before and after irradiation with visible light, the inventors determined that if the color difference ΔE in JIS Z 8781 is 20 or less (ΔE≦20), the edible ink has sufficient light resistance to withstand practical use and was passed in this evaluation. The specific light resistance evaluation criteria are as follows.

[0098] ◎: ΔE is 10 or less (ΔE≦10) ○: ΔE is 20 or less (ΔE≦20) △: ΔE is 30 or less (ΔE≦30) ×: ΔE exceeds 30 (ΔE>30) In this evaluation, the result of the lower evaluation, between the printed matter of the plain tablets and the printed matter of the film-coated tablets, is shown in the table as the overall evaluation result. Regarding the optical color density (print density), if the measured value is 0.15 or more, the edible ink is deemed to have sufficient visibility for practical use and is deemed to have passed this evaluation. The specific evaluation criteria for optical color density (print density) are as follows:

[0099] ◎: 0.50 or more 〇: 0.15 or more ×: Less than 0.15 In addition, "C," "M," and "Y" in the print density column stand for "cyan," "magenta," and "yellow," respectively. In addition, in this evaluation, the result of the lower evaluation between the printed matter of the plain tablets and the printed matter of the film-coated tablets is shown in the table as the overall evaluation result.

[0100] (Intermittent restartability test) Using a piezoelectric ceramic-driven drop-on-demand inkjet head with a print resolution of 600 dpi in the main scanning direction, 600 dpi in the sub-scanning direction (direction of conveyance of recording media such as tablets), and a total of 2,656 nozzles, a test pattern was printed with a print drop amount of 6 pl per drop after leaving it for a specified time (15 to 60 minutes) without flushing, and it was confirmed that all nozzles were ejected without any non-ejection. In addition, in Tables 1 to 4 below, the leaving time during which the ink could be ejected was measured as an evaluation result of intermittent resumability. If the leaving time was 30 minutes or more, the edible ink was deemed to have sufficient intermittent resumability to withstand practical use, and was evaluated as passing in this evaluation. The evaluation results are as follows.

[0101] ◎: 60 minutes or more and less than 120 minutes ○: 30 minutes or more but less than 60 minutes △: 15 minutes or more but less than 30 minutes ×: Less than 15 minutes

[0102] The composition and evaluation results of the edible ink of each Example are shown in Tables 1, 3, and 4. The composition and evaluation results of the edible ink of each Comparative Example are shown in Table 2. In Tables 1 to 4, "-" indicates that the corresponding substance was not used. In Tables 1 to 4, film-coated tablets are abbreviated as "FC tablets."

[0103] [Table 1]

[0104] [Table 2]

[0105] [Table 3]

[0106] [Table 4]

[0107] As shown in Tables 1, 3, and 4, in the plain tablet prints and film-coated tablet prints of Examples 1-1 to 1-42, the color difference ΔE before and after irradiation with visible light was 20 or less (ΔE≦20) as a result of the light resistance test. In other words, it was found that the tablet forms of Examples 1-1 to 1-42 sufficiently suppressed the light discoloration and light fading of the printed image, and excellent light resistance was imparted. In contrast, as shown in Table 2, in the tablet forms of Comparative Examples 1-1 to 1-8, the color difference ΔE before and after irradiation with visible light was a value exceeding 20 (ΔE>20) as a result of the light resistance test. In other words, it was found that the tablet forms of Comparative Examples 1-1 to 1-8 could not sufficiently suppress the light discoloration and light fading of the printed image, and the light resistance was insufficient.

[0108] From the results of the above light resistance test, the water vapor permeability is 1.0g / m2 It was found that tablets printed with edible ink containing at least a colorant selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3, packaged in a water vapor barrier packaging material with a viscosity of 1.0 MPa or less, sufficiently suppressed photodiscoloration and photofading, and had improved light resistance.

[0109] Additionally, we learned the following about the edible ink formulation: When the amount of antioxidant (reducing agent) that is solid at room temperature is increased, the viscosity of the edible ink tends to increase. Therefore, if the amount of antioxidant added exceeds the amounts described in Examples 1-1 to 1-42, the intermittent restartability may deteriorate. Furthermore, although the antioxidant exhibits a discoloration suppression effect even when added in a small amount, if the amount of the antioxidant added is too small relative to the amount of the coloring material added, it may be difficult to obtain the effect.

[0110] In addition, when the amount of coloring material added is large, the print density is high and the visibility is improved, but if the amount added is too large, the viscosity of the edible ink may increase. As a result, the intermittent restartability may deteriorate. Furthermore, when the amount of coloring material added exceeds a certain amount, the increase in print density may become gradual. Furthermore, if the amount of coloring material added is small, the print density may be low and visibility may be poor. Therefore, if the amount of coloring material added is less than the amounts described in Examples 1-1 to 1-42, visibility may be impaired.

[0111] (Second Example) <Example 2-1> The procedure for preparing the edible ink according to Example 2-1 will be described below. (Manufacturing edible ink) First, a printing ink was prepared. The edible ink contains the following components: a dye (coloring material), a solvent, and an antioxidant (reducing agent). The preparation procedure was as follows: first, water was mixed with propylene glycol and ethanol to obtain a mixed solvent. Next, reduced isomaltulose, which is an antioxidant, was added to the mixed solvent. Next, a coloring material was added to the mixed solvent at 25°C, and the mixture was stirred for a certain period of time (for example, 60 minutes). In this way, the ink according to this embodiment was prepared. The various components will be specifically described below.

[0112] In this example, the food dye Blue No. 1 was added as a coloring material to the above-mentioned solvent, and the mixture was stirred for about 1 hour to obtain the edible ink of Example 2-1. The blending ratio of the coloring material Blue No. 1 was 0.01% by mass, the blending ratio of purified water in the solvent was 65.39% by mass, the blending ratio of propylene glycol was 28.00% by mass, and the blending ratio of ethanol was 6.5% by mass, relative to the entire edible ink of Example 2-1. In addition, the blending ratio of reduced isomaltulose as an antioxidant was 0.10% by mass.

[0113] Next, the edible ink of Example 2-1 was passed through a membrane filter to remove solid foreign matter in the liquid. Specifically, the ink was passed once through a membrane filter (cellulose acetate membrane) with a diameter of 5.0 μm, and then once through a membrane filter (cellulose acetate membrane) with a diameter of 0.8 μm to obtain a purified ink. The tablet having the image printed with the edible ink (refined ink) thus obtained was subjected to a water vapor transmission rate of 0.25 g / m 2 d and the oxygen permeability is 0.66 cm 3 / m 2 The product was packaged in a barrier PTP packaging material. In this example, the refined edible ink was printed on a tablet in a room temperature and humidity environment, and then hot air at 40° C. was blown for 10 seconds using a continuous drying mechanism to obtain a printed image.

[0114] <Example 2-2> The edible ink of Example 2-2 was obtained in the same manner as Example 2-1, except that the blending ratio of Blue No. 1 was 0.10 mass%, the blending ratio of purified water was 64.40 mass%, and the blending ratio of reduced isomaltulose was 1.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1.

[0115] <Example 2-3> The edible ink of Example 2-3 was obtained in the same manner as Example 2-1, except that the blending ratio of Blue No. 1 was 0.70 mass%, the blending ratio of purified water was 57.80 mass%, and the blending ratio of reduced isomaltulose was 7.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1.

[0116] <Example 2-4> The edible ink of Example 2-4 was obtained in the same manner as Example 2-1, except that the food dye Yellow No. 4 was added as a coloring material and no antioxidant was added. In this example, the blending ratio of Yellow No. 4 was 0.01 mass %, and the blending ratio of purified water was 65.49 mass %. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1.

[0117] <Example 2-5> An edible ink of Example 2-5 was obtained in the same manner as in Example 2-4, except that the blending ratio of Yellow No. 4 was 0.10 mass % and the blending ratio of purified water was 65.40 mass %. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1.

[0118] <Example 2-6> An edible ink of Example 2-6 was obtained in the same manner as in Example 2-4, except that the blending ratio of Yellow No. 4 was 0.70 mass % and the blending ratio of purified water was 64.80 mass %. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1.

[0119] <Example 2-7> The edible ink of Example 2-7 was obtained in the same manner as Example 2-1, except that the food dye Red No. 102 was added as a coloring material and lactose was added as an antioxidant. In this example, the blending ratio of Red No. 102 was 0.01% by mass, the blending ratio of purified water was 65.46% by mass, and the blending ratio of lactose was 0.03% by mass. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1.

[0120] <Example 2-8> The edible ink of Example 2-8 was obtained in the same manner as Example 2-7, except that the blending ratio of Red No. 102 was 0.10 mass%, the blending ratio of purified water was 65.10 mass%, and the blending ratio of lactose was 0.30 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1.

[0121] <Example 2-9> The edible ink of Example 2-9 was obtained in the same manner as Example 2-7, except that the blending ratio of Red No. 102 was 0.70 mass%, the blending ratio of purified water was 62.70 mass%, and the blending ratio of lactose was 2.10 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1.

[0122] <Example 2-10> The edible ink of Example 2-10 was obtained in the same manner as Example 2-1, except that Red No. 3, an edible dye, was added as a coloring material, and potassium citrate was added as an antioxidant. In this example, the blending ratio of Red No. 3 was 0.01% by mass, the blending ratio of purified water was 65.48% by mass, and the blending ratio of potassium citrate was 0.01% by mass. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1.

[0123] <Example 2-11> The edible ink of Example 2-11 was obtained in the same manner as Example 2-10, except that the blending ratio of Red No. 3 was 0.10 mass%, the blending ratio of purified water was 65.30 mass%, and the blending ratio of potassium citrate was 0.10 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1.

[0124] <Example 2-12> The edible ink of Example 2-12 was obtained in the same manner as Example 2-10, except that the blending ratio of Red No. 3 was 0.70 mass%, the blending ratio of purified water was 64.10 mass%, and the blending ratio of potassium citrate was 0.70 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1.

[0125] <Example 2-13> The tablet having the image printed with the edible ink of Example 2-1 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0126] <Example 2-14> The tablet having the printed image printed with the edible ink of Example 2-2 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0127] <Example 2-15> The tablet having the printed image printed with the edible ink of Example 2-3 was placed in a container having a water vapor transmission rate of 0.55 g / m 2The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0128] <Example 2-16> The tablet having the printed image printed with the edible ink of Example 2-4 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0129] <Example 2-17> The tablet having the printed image printed with the edible ink of Examples 2-5 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0130] <Example 2-18> The tablets having the printed images printed with the edible inks of Examples 2-6 were then subjected to drying at 30°C for 10 min at 20°C for 10 min at 20°C. 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0131] <Example 2-19> The tablets having the images printed with the edible inks of Examples 2-7 were then subjected to a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0132] <Example 2-20> The tablet having the printed image printed with the edible ink of Examples 2-8 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0133] <Example 2-21> The tablet having the printed image printed with the edible ink of Examples 2-9 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0134] <Example 2-22> The tablet having the printed image printed with the edible ink of Example 2-10 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0135] <Example 2-23> The tablet having the printed image printed with the edible ink of Example 2-11 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0136] <Example 2-24> The tablet having the printed image printed with the edible ink of Example 2-12 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0137] <Example 2-25> The edible ink of Example 2-25 was obtained in the same manner as Example 2-1, except that food dyes Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 were added as coloring materials. In this example, the blending ratio of Blue No. 1 was 0.52% by mass, the blending ratio of Yellow No. 4 was 0.26% by mass, the blending ratio of Red No. 102 was 0.91% by mass, the blending ratio of Red No. 3 was 0.07% by mass, the blending ratio of purified water was 55.80% by mass, and the blending ratio of reduced isomaltulose was 7.94% by mass. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1. The edible ink of Example 2-25 is an ink whose color tone has been finely adjusted and which exhibits a gray color.

[0138] <Example 2-26> The edible ink of Example 2-26 was obtained in the same manner as Example 2-1, except that the food dyes Blue No. 1 and Red No. 102 were added as coloring materials. In this example, the blending ratio of Blue No. 1 was 0.94 mass%, the blending ratio of Red No. 102 was 0.34 mass%, the blending ratio of purified water was 56.80 mass%, and the blending ratio of reduced isomaltulose was 7.42 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1. The edible ink of Example 2-26 is an ink whose color tone has been finely adjusted and which exhibits a blue color.

[0139] <Example 2-27> The edible ink of Example 2-27 was obtained in the same manner as Example 2-1, except that the food dyes Blue No. 1, Yellow No. 4, and Red No. 102 were added as colorants. In this example, the blending ratio of Blue No. 1 was 0.61% by mass, the blending ratio of Yellow No. 4 was 0.87% by mass, the blending ratio of Red No. 102 was 0.78% by mass, the blending ratio of purified water was 56.05% by mass, and the blending ratio of reduced isomaltulose was 7.20% by mass. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1. The edible ink of Example 2-27 is an ink whose color tone has been finely adjusted and which exhibits a green color.

[0140] <Example 2-28> The edible ink of Example 2-28 was obtained in the same manner as Example 2-1, except that food dyes Blue No. 1 and Yellow No. 4 were added as coloring materials. In this example, the blending ratio of Blue No. 1 was 0.50 mass%, the blending ratio of Yellow No. 4 was 2.00 mass%, the blending ratio of purified water was 55.00 mass%, and the blending ratio of reduced isomaltulose was 10.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1. The edible ink of Example 2-28 is an ink whose color tone has been finely adjusted and which exhibits a yellow-green color.

[0141] <Example 2-29> The edible ink of Example 2-29 was obtained in the same manner as Example 2-1, except that food dyes Blue No. 1, Yellow No. 4, and Red No. 102 were added as colorants, and lactose was added as an antioxidant. In this example, the blending ratio of Blue No. 1 was 0.08% by mass, the blending ratio of Yellow No. 4 was 0.08% by mass, the blending ratio of Red No. 102 was 1.31% by mass, the blending ratio of purified water was 60.53% by mass, and the blending ratio of lactose was 3.50% by mass. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1. The edible ink of Example 2-29 is an ink whose color tone has been finely adjusted and which exhibits a reddish brown color.

[0142] <Example 2-30> The edible ink of Example 2-30 was obtained in the same manner as Example 2-1, except that food dyes Blue No. 1 and Red No. 3 were added as coloring materials, and reduced isomaltulose and potassium citrate were added as antioxidants. In this example, the blending ratio of Blue No. 1 was 0.09 mass%, the blending ratio of Red No. 3 was 2.41 mass%, the blending ratio of purified water was 59.69 mass%, the blending ratio of reduced isomaltulose was 0.72 mass%, and the blending ratio of potassium citrate was 5.00 mass%. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1. The edible ink of Example 2-30 is an ink whose color tone has been finely adjusted and which exhibits a pink color.

[0143] <Example 2-31> The edible ink of Example 2-31 was obtained in the same manner as Example 2-1, except that food dyes Blue No. 1, Yellow No. 4, and Red No. 3 were added as coloring materials, and reduced isomaltulose and potassium citrate were added as antioxidants. In this example, the blending ratio of Blue No. 1 was 0.09% by mass, the blending ratio of Yellow No. 4 was 0.09% by mass, the blending ratio of Red No. 3 was 2.25% by mass, the blending ratio of purified water was 59.69% by mass, the blending ratio of reduced isomaltulose was 0.72% by mass, and the blending ratio of potassium citrate was 5.00% by mass. The tablets thus obtained, having the images printed with the edible ink, were packaged in the same barrier PTP packaging material as in Example 2-1. The edible ink of Example 2-31 is an ink whose color tone has been finely adjusted and which exhibits a dull pink color.

[0144] <Example 2-32> The tablet having the printed image printed with the edible ink of Example 2-25 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0145] <Example 2-33> The tablet having the printed image printed with the edible ink of Example 2-26 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0146] <Example 2-34> The tablet having the printed image printed with the edible ink of Example 2-27 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0147] <Example 2-35> The tablet having the printed image printed with the edible ink of Example 2-28 was placed in a container having a water vapor transmission rate of 0.55 g / m2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0148] <Example 2-36> The tablet having the printed image printed with the edible ink of Example 2-29 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0149] <Example 2-37> The tablet having the printed image printed with the edible ink of Example 2-30 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0150] <Example 2-38> The tablet having the printed image printed with the edible ink of Example 2-31 was placed in a container having a water vapor transmission rate of 0.55 g / m 2 The samples were packaged in a barrier PTP packaging material ("Super Foil CPP Sheet: EG030NA" manufactured by Mitsubishi Chemical Corporation).

[0151] <Comparative Example 2-1> The tablet having the printed image printed with the edible ink of Example 2-1 was placed in a container having a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0152] <Comparative Example 2-2> The tablet having the printed image printed with the edible ink of Example 2-2 was placed in a container having a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0153] <Comparative Example 2-3> The tablet having the printed image printed with the edible ink of Example 2-3 was placed in a container having a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0154] <Comparative Example 2-4> The tablet having the printed image printed with the edible ink of Example 2-4 was placed in a container having a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0155] <Comparative Example 2-5> The tablet having the printed image printed with the edible ink of Examples 2-5 was placed in a container having a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0156] <Comparative Example 2-6> The tablet having the printed image printed with the edible ink of Examples 2-6 was placed in a container having a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0157] <Comparative Example 2-7> The tablet having the printed image printed with the edible ink of Examples 2-7 was placed in a container having a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0158] <Comparative Example 2-8> The tablet having the printed image printed with the edible ink of Example 2-8 was placed in a container having a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0159] <Comparative Example 2-9> The tablet having the printed image printed with the edible ink of Example 2-9 was subjected to drying with a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0160] <Comparative Example 2-10> The tablet having the printed image printed with the edible ink of Example 2-10 was placed in a container having a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0161] <Comparative Example 2-11> The tablet having the printed image printed with the edible ink of Example 2-11 was subjected to drying with a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0162] <Comparative Example 2-12> The tablet having the printed image printed with the edible ink of Example 2-12 was placed in a container having a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0163] <Comparative Example 2-13> The tablets with the printed image printed with the edible ink of Example 2-1 were not packaged.

[0164] <Comparative Example 2-14> The tablets with the printed image printed with the edible ink of Example 2-2 were not packaged.

[0165] <Comparative Example 2-15> The tablets with the printed image printed with the edible ink of Example 2-3 were not packaged.

[0166] <Comparative Example 2-16> The tablets with the printed images printed with the edible ink of Examples 2-4 were not packaged.

[0167] <Comparative Example 2-17> The tablets with the printed images printed with the edible ink of Examples 2-5 were not packaged.

[0168] <Comparative Example 2-18> The tablets with the printed images printed with the edible ink of Examples 2-6 were not packaged.

[0169] <Comparative Example 2-19> The tablets with the printed images printed with the edible ink of Examples 2-7 were not packaged.

[0170] <Comparative Example 2-20> The tablets with the printed images printed with the edible ink of Examples 2-8 were not packaged.

[0171] <Comparative Example 2-21> The tablets with the printed images printed with the edible ink of Examples 2-9 were not packaged.

[0172] <Comparative Example 2-22> The tablets with the printed images printed with the edible ink of Examples 2-10 were not packaged.

[0173] <Comparative Example 2-23> The tablets with the printed images printed with the edible ink of Examples 2-11 were not packaged.

[0174] <Comparative Example 2-24> The tablets with the printed images printed with the edible ink of Examples 2-12 were not packaged.

[0175] <Comparative Example 2-25> The tablet having the printed image printed with the edible ink of Example 2-25 was subjected to drying with a water vapor transmission rate of 4.6 g / m 2The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0176] <Comparative Example 2-26> The tablet having the printed image printed with the edible ink of Example 2-26 was subjected to drying with a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0177] <Comparative Example 2-27> The tablet having the printed image printed with the edible ink of Example 2-27 was subjected to drying with a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0178] <Comparative Example 2-28> The tablet having the printed image printed with the edible ink of Example 2-28 was placed in a container having a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0179] <Comparative Example 2-29> The tablet having the printed image printed with the edible ink of Example 2-29 was placed in a container having a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0180] <Comparative Example 2-30> The tablet having the printed image printed with the edible ink of Example 2-30 was subjected to drying with a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0181] <Comparative Example 2-31> The tablet having the printed image printed with the edible ink of Example 2-31 was subjected to drying with a water vapor transmission rate of 4.6 g / m 2 The samples were packaged in a barrier PTP packaging material (Mitsubishi Chemical Corporation's "Vinifoil Hard PVC Sheet: C-0471").

[0182] <Comparative Example 2-32> The tablets with the printed images printed with the edible ink of Examples 2-25 were not packaged.

[0183] <Comparative Example 2-33> The tablets with the printed images printed with the edible ink of Examples 2-26 were not packaged.

[0184] <Comparative Example 2-34> The tablets with the printed image printed with the edible ink of Examples 2-27 were not packaged.

[0185] <Comparative Example 2-35> The tablets with the printed image printed with the edible ink of Examples 2-28 were not packaged.

[0186] <Comparative Example 2-36> The tablets with the printed image printed with the edible ink of Examples 2-29 were not packaged.

[0187] <Comparative Example 2-37> The tablets with the printed images printed with the edible ink of Examples 2-30 were not packaged.

[0188] <Comparative Example 2-38> The tablets with the printed image printed with the edible ink of Example 2-31 were not packaged.

[0189] <Evaluation> The print density and light resistance of the images printed with the inks of the above Examples and Comparative Examples were evaluated by the following methods. The intermittent restartability of the inks of the above Examples and Comparative Examples was also evaluated by the following methods. The evaluation results are shown in Tables 5 to 10.

[0190] (Print density and light resistance test) Using a piezoelectric ceramic-driven drop-on-demand inkjet head with a printing resolution of 600 dpi in the main scanning direction, 600 dpi in the sub-scanning direction (the direction in which the recording medium such as tablets is transported), and a total of 2,656 nozzles, images were printed on the tablets listed below using the refined inks of Examples 2-1 to 2-38 and Comparative Examples 2-1 to 2-38 above at a printing drop volume of 6 pl per drop. The tablets to be printed were test plain tablets (base: adjusted starch, diameter: 6.5 mm) and test film-coated tablets (base: adjusted starch, coating agent: mixture of 70% hydroxypropyl methylcellulose and 30% titanium oxide, diameter: 6.5 mm). The printed image was a circular solid image (diameter 4.0 mm). In this way, plain tablet prints and film-coated tablet prints were obtained.

[0191] The plain tablet prints and the film-coated tablet prints of each Example and Comparative Example, in which the chromaticity and optical color density (print density) were measured, were irradiated with a cumulative visible light of 1.2 million lux using a xenon weather meter (Toyo Seiki Co., Ltd. Ci4000) while packaged in a packaging material. The chromaticity and optical color density of the plain tablet prints and the film-coated tablet prints irradiated with visible light were measured with a spectrophotometer, and the color difference ΔE (based on JIS Z 8781), which indicates the amount of change in chromaticity and optical color density before and after irradiation with visible light, was compared. The results of the comparison are shown in Tables 5 to 10. As described above, regarding the change in color before and after irradiation with visible light, the inventors determined that if the color difference ΔE in JIS Z 8781 is 20 or less (ΔE≦20), the edible ink has sufficient light resistance to withstand practical use and was passed in this evaluation. The specific light resistance evaluation criteria are as follows.

[0192] ◎: ΔE is 10 or less (ΔE≦10) ○: ΔE is 20 or less (ΔE≦20) △: ΔE is 30 or less (ΔE≦30) ×: ΔE exceeds 30 (ΔE>30) In this evaluation, the result of the lower evaluation, between the printed matter of the plain tablets and the printed matter of the film-coated tablets, is shown in the table as the overall evaluation result.

[0193] Regarding the optical color density (print density), if the measured value is 0.15 or more, the edible ink is deemed to have sufficient visibility for practical use and is deemed to have passed this evaluation. The specific evaluation criteria for optical color density (print density) are as follows:

[0194] ◎: 0.50 or more 〇: 0.15 or more ×: Less than 0.15 In addition, "C," "M," and "Y" in the print density column stand for "cyan," "magenta," and "yellow," respectively.

[0195] In addition, in this evaluation, the result of the lower evaluation between the printed matter of the plain tablets and the printed matter of the film-coated tablets is shown in the table as the overall evaluation result.

[0196] (Intermittent restartability test) Using a piezoelectric ceramic-driven drop-on-demand inkjet head with a print resolution of 600 dpi in the main scanning direction, 600 dpi in the sub-scanning direction (direction of conveyance of recording media such as tablets), and a total of 2,656 nozzles, a test pattern was printed with a print drop amount of 6 pl per drop after leaving it for a specified time (15 minutes to 60 minutes) without flushing, and it was confirmed that all nozzles were ejected without any non-ejection. In addition, in Tables 5 to 10 below, the leaving time during which the ink could be ejected was measured as an evaluation result of intermittent resumability. If the leaving time was 30 minutes or more, the edible ink was deemed to have sufficient intermittent resumability to withstand practical use, and was evaluated as passing in this evaluation. The evaluation results are as follows.

[0197] ◎: 60 minutes or more but less than 120 minutes ○: 30 minutes or more but less than 60 minutes △: 15 minutes or more but less than 30 minutes ×: Less than 15 minutes

[0198] The composition and evaluation results of the edible ink of each Example are shown in Tables 5 to 7. The composition and evaluation results of the edible ink of each Comparative Example are shown in Tables 8 to 10. In Tables 5 to 10, "-" indicates that the corresponding substance was not used. In Tables 5 to 10, film-coated tablets are abbreviated as "FC tablets."

[0199] [Table 5]

[0200] [Table 6]

[0201] [Table 7]

[0202] [Table 8]

[0203] [Table 9]

[0204] [Table 10]

[0205] As shown in Tables 5 to 7, in the plain tablet prints and film-coated tablet prints of Examples 2-1 to 2-38, the color difference ΔE before and after irradiation with visible light was 20 or less (ΔE≦20) as a result of the light resistance test. In other words, it was found that the tablet forms of Examples 2-1 to 2-38 sufficiently suppressed the light discoloration and light fading of the printed image, and excellent light resistance was imparted. In contrast, as shown in Tables 8 to 10, in the tablet forms of Comparative Examples 2-1 to 2-38, the color difference ΔE before and after irradiation with visible light was a value exceeding 20 (ΔE>20) as a result of the light resistance test. In other words, it was found that the tablet forms of Comparative Examples 2-1 to 2-38 could not sufficiently suppress the light discoloration and light fading of the printed image, and the light resistance was insufficient.

[0206] From the results of the above light resistance test, the water vapor permeability is 1.0g / m 2 It was found that tablets printed with edible ink containing at least a colorant selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3, packaged in a water vapor barrier packaging material with a viscosity of 1.0 MPa or less, sufficiently suppressed photodiscoloration and photofading, and had improved light resistance.

[0207] Additionally, we learned the following about the edible ink formulation: The technology disclosed in this application allows finer adjustment of color tone compared to conventional technologies. In many of the mixed color inks according to the prior art, antioxidants are added to each of the pigments, but in such mixed color inks, the viscosity of the ink increases and the ejection properties tend to deteriorate.

[0208] For such high viscosity inks, as shown in Examples 2-25 to 2-38, by adding an antioxidant with a fading suppression effect to highly color-developing pigments or pigments added in large amounts, excellent fading suppression effects could be obtained and changes in color tone could be suppressed. In this embodiment, the dye with the highest color development is Blue No. 1, followed by Red No. 3, Red No. 102, and Yellow No. 4 in that order.

[0209] The scope of the present invention is not limited to the exemplary embodiments shown and described, but includes all embodiments that achieve equivalent effects to the object of the present invention. Moreover, the scope of the present invention is not limited to the combination of inventive features defined by the claims, but may be defined by any desired combination of specific features among all the respective disclosed features.

[0210] Moreover, for example, this embodiment can have the following configuration. (1) Water vapor permeability is 1.0g / m 2 A tablet printed with edible ink containing at least a coloring material selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3, packaged in a water vapor barrier packaging material having a water vapor barrier property of not more than d. (2) The edible ink further comprises an antioxidant, When the coloring material contains Blue No. 1, the antioxidant contains reduced isomaltulose, When the coloring material contains Red No. 102, the antioxidant contains lactose, The tablet according to (1) above, characterized in that when the coloring material contains Red No. 3, the antioxidant contains potassium citrate. (3) Water vapor permeability is 1.0g / m 2 The present invention relates to a packaging material having a water vapor barrier property of d or less, the packaging material comprising at least a coloring material selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3, a solvent, and an antioxidant, The solvent includes water, ethanol, and propylene glycol; When the coloring material contains Blue No. 1, the antioxidant contains reduced isomaltulose, When the coloring material contains Red No. 102, the antioxidant contains lactose, When the coloring material contains Red No. 3, the antioxidant contains potassium citrate, When the coloring material contains only the Yellow No. 4, the coloring material does not contain any of the reduced isomaltulose, the lactose, and the potassium citrate; The content of the Blue No. 1 is within a range of 0.01% by mass or more and 0.90% by mass or less with respect to the total mass of the edible ink, and the content of the reduced isomaltulose is within a range of 2.00% by mass or more and 25.00% by mass or less with respect to the total mass of the edible ink, The content of Red No. 102 is within a range of 0.01% by mass or more and 0.90% by mass or less with respect to the total mass of the edible ink, and the content of lactose is within a range of 1.00% by mass or more and 25.00% by mass or less with respect to the total mass of the edible ink, A tablet printed with edible ink, wherein the content of Red No. 3 is within the range of 0.01% by mass or more and 0.90% by mass or less relative to the total mass of the edible ink, and the content of potassium citrate is within the range of 0.50% by mass or more and 30.00% by mass or less relative to the total mass of the edible ink. (4) The tablet according to (3) above, printed with an edible ink containing all of Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 as the coloring material, an edible ink containing Blue No. 1 and Red No. 102, an edible ink containing Blue No. 1, Yellow No. 4, and Red No. 102, an edible ink containing Blue No. 1 and Yellow No. 4, an edible ink containing Blue No. 1, Yellow No. 4, and Red No. 3, or an edible ink containing Blue No. 1 and Red No. 3. (5) Water vapor permeability is 1.0g / m 2 The tablet according to any one of (1) to (4) above, characterized in that it is packaged in a barrier PTP packaging material having a viscosity of 0.1 to 1.0 MPa (d) or less. (6) Water vapor permeability is 0.5g / m 2 d or less, and the oxygen permeability is 3.0 cm 3 / m 2 The tablet according to any one of (1) to (4) above, characterized in that it is packaged in a barrier PTP packaging material having a viscosity of 0.1 to 1.0 MPa (d) or less. (7) The tablet according to any one of (1) to (6) above, characterized in that the color difference (ΔE) before and after a light resistance test is 20 or less. (8) A tablet having a printed portion printed with an edible ink containing at least a coloring material selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3 is placed in a container having a water vapor transmission rate of 1.0 g / m 2 A method for storing tablets, comprising packaging the tablets in a barrier packaging material having a barrier property of d or less. (9) The ink contains at least a coloring material selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3, a solvent, and an antioxidant; The solvent includes water, ethanol, and propylene glycol; When the coloring material contains Blue No. 1, the antioxidant contains reduced isomaltulose, When the coloring material contains Red No. 102, the antioxidant contains lactose, When the coloring material contains Red No. 3, the antioxidant contains potassium citrate, When the coloring material contains only the Yellow No. 4, the coloring material does not contain any of the reduced isomaltulose, the lactose, and the potassium citrate; The content of the Blue No. 1 is within a range of 0.01% by mass or more and 0.90% by mass or less with respect to the total mass of the edible ink, and the content of the reduced isomaltulose is within a range of 2.00% by mass or more and 25.00% by mass or less with respect to the total mass of the edible ink, The content of Red No. 102 is within a range of 0.01% by mass or more and 0.90% by mass or less with respect to the total mass of the edible ink, and the content of lactose is within a range of 1.00% by mass or more and 25.00% by mass or less with respect to the total mass of the edible ink, The content of Red No. 3 is within the range of 0.01% by mass to 0.90% by mass, and the content of potassium citrate is within the range of 0.50% by mass to 30.00% by mass, based on the total mass of the edible ink. 2 A method for storing tablets, comprising packaging the tablets in a barrier packaging material having a barrier property of d or less. [Explanation of symbols]

[0211] 1 Tablet base material 3 Print image 5 Plain tablet printout 7 Film Coating Layer 9 Film-coated tablet printouts 11 Plain tablet print image (solid image) 13 Film-coated tablet print image (2D barcode) 20 Multi-layer sheet 21 Sealant layer 22 Water vapor barrier adhesive layer 23 Oxygen gas barrier substrate 24 Water vapor barrier adhesive layer 25 Sealant Layer 26 Sealing member 27 Bottom material 28 Storage area

Claims

1. Water vapor permeability is 1.0g / m ２ A tablet printed with edible ink containing at least a coloring material selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3, packaged in a water vapor barrier packaging material having a viscosity of d or less.

2. The edible ink further comprises an antioxidant, When the coloring material contains Blue No. 1, the antioxidant contains reduced isomaltulose, When the coloring material contains Red No. 102, the antioxidant contains lactose, The tablet according to claim 1, characterized in that when the coloring material contains Red No. 3, the antioxidant contains potassium citrate.

3. Water vapor permeability is 1.0g / m ２ The tablet according to claim 1, characterized in that it is packaged in a barrier PTP packaging material having a molecular weight of d or less.

4. Water vapor permeability is 0.5g / m ２ d or less, and the oxygen permeability is 3.0 cm ３ / m ２ The tablet according to claim 1, characterized in that it is packaged in a barrier PTP packaging material having a molecular weight of d or less.

5. The tablet according to claim 3 or 4, characterized in that the color difference (ΔE) before and after a light resistance test is 20 or less.

6. Water vapor permeability is 1.0g / m ２ The present invention includes at least a coloring material selected from Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3, a solvent, and an antioxidant, which are packaged in a water vapor barrier packaging material having a water vapor barrier property of d or less, The solvent includes water, ethanol, and propylene glycol; When the coloring material contains Blue No. 1, the antioxidant contains reduced isomaltulose, When the coloring material contains Red No. 102, the antioxidant contains lactose, When the coloring material contains Red No. 3, the antioxidant contains potassium citric acid, When the coloring material contains only the Yellow No. 4, the coloring material does not contain any of the reduced isomaltulose, the lactose, and the potassium citrate, The content of the Blue No. 1 is in the range of 0.01% by mass or more and 0.90% by mass or less with respect to the total mass of the edible ink, and the content of the reduced isomaltulose is in the range of 2.00% by mass or more and 25.00% by mass or less with respect to the total mass of the edible ink, The content of Red No. 102 is in the range of 0.01% by mass or more and 0.90% by mass or less with respect to the total mass of the edible ink, and the content of lactose is in the range of 1.00% by mass or more and 25.00% by mass or less with respect to the total mass of the edible ink, A tablet printed with edible ink, wherein the content of Red No. 3 is within the range of 0.01% by mass or more and 0.90% by mass or less relative to the total mass of the edible ink, and the content of potassium citric acid is within the range of 0.50% by mass or more and 30.00% by mass or less relative to the total mass of the edible ink.

7. The tablet according to claim 6, printed with an edible ink containing all of Blue No. 1, Yellow No. 4, Red No. 102, and Red No. 3, an edible ink containing Blue No. 1 and Red No. 102, an edible ink containing Blue No. 1, Yellow No. 4, and Red No. 102, an edible ink containing Blue No. 1 and Yellow No. 4, an edible ink containing Blue No. 1, Yellow No. 4, and Red No. 3, or an edible ink containing Blue No. 1 and Red No. 3, as the coloring material.

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