Skin external agent composition

Abstract

To provide compositions containing a combination of raw materials that work synergistically when mixed together from among the many cosmetic raw materials, and to provide compositions containing a combination of multiple raw materials that synergistically improve the feel of use.SOLUTION: The above problems are solved by a composition containing an extract of Ganoderma lucidum or deer horn shape Ganoderma lucidum, an extract of Larix sibirica wood, and an extract of sake lees.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a technology for combining multiple functional raw materials in skin cosmetics or skin external preparations. In many cases, not only in skin cosmetics but in the field of cosmetics, in addition to the base raw materials and raw materials blended for the purpose of maintaining quality, various functional raw materials are used in the hope of improving efficacy and usability. It is most desirable for the combination of these functional raw materials to synergistically enhance the effects of the cosmetic, including the usability. On the other hand, it is not easy to predict the difference that will be caused by the differences in several blended raw materials when it comes to the usability obtained when applying extracts of natural products or mixtures of various compounds to the skin. Finding a specific combination that produces a synergistic beneficial effect for cosmetic raw materials with different functions can be useful in the development of new cosmetic products. [Background technology]

[0002] Cosmetic raw materials known to have the functionality of the present invention include antler reishi extract, Siberian larch wood extract, and sake lees extract. The antler reishi extract is known for its moisturizing properties provided by polysaccharides and its function of inhibiting melanin production due to its low molecular weight components. Siberian larch wood extract has been reported to have antioxidant activity due to its main component dihydroquercetin. Sake lees extract has also been reported to induce the expression of heat shock proteins that protect cells from various stresses, and is expected to prevent roughness caused by various stresses or promote recovery from roughness when applied externally to the skin.

[0003] In the field of cosmetics, there is a constant demand for novel products, and reflecting this situation, there is a constant demand for the development of various functional raw materials for cosmetics, and a wide variety of both old and new cosmetic raw materials are being supplied. There is a demand for effective combinations of these to develop highly useful cosmetic products. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Patent Publication No. 2001-131083 [Patent Document 2] Patent Publication 2013-10698 [Patent Document 3] Patent Publication No. 2020-172468 [Non-patent literature]

[0005] [Non-Patent Document 1] Communication in Pharmacology and Toxicology: 5, 175, 2000 The methanol-soluble extract from the antler-shape fruiting body of Ganoderma lucidum inhibits melanin synthesis in B16 melanoma:Research [Non-Patent Document 2] Cells VOL.34; No.12, PAGE.499-501 (2002) Melanin synthesis inhibitors derived from antler Ganoderma lucidum Summary of the Invention [Problem to be solved by the invention]

[0006] It is an important task to search for and find combinations of cosmetic raw materials with different functionalities that synergistically enhance the usefulness of the raw materials in a specific evaluation point compared to when each raw material is used alone. Raw materials with different characteristics that have useful physiologically active functionalities are mixed to find combinations that synergistically enhance the evaluation of the feeling of use. The object of the present invention is to provide skin cosmetics and the like that are more useful by finding such combinations. [Means for solving the problem]

[0007] As a result of intensive research aimed at solving the above problems, the inventors discovered that the use of a composition containing antler reishi (or ganoderma lucidum) extract, Siberian larch wood extract, and sake lees extract can synergistically improve the sensation of use, and thus completed the present invention.

[0008] Thus, the present invention provides a skin cosmetic or topical skin preparation that is highly useful in terms of the sensation of use. By applying the skin cosmetic or topical skin preparation of the present invention to the human body, it is possible to provide highly satisfying results in terms of basic sensations during use, such as a moist feeling and low irritation. Effect of the Invention

[0009] The antler reishi (or lingzhi) extract, Siberian larch wood extract, and sake lees extract used in the present invention are derived from natural products that are widely used as foods, etc., and are considered to have few safety issues as materials applied to the human body. In addition, the antler reishi (or lingzhi) extract, Siberian larch wood extract, and sake lees extract have a track record of being incorporated into cosmetics as raw materials. The present invention utilizes the antler reishi extract, Siberian larch wood extract, and sake lees extract, and has the advantage that they can be safely applied to the human body as skin cosmetics or skin topicals. The antler reishi (or ganoderma lucidum), extract of Siberian larch wood, and sake lees are commercially available and therefore easy to obtain, and another advantage of the present invention is that these raw materials can be relatively easily processed into cosmetic ingredients. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The antler reishi (or ganoderma lucidum) extract, Siberian larch wood extract and sake lees extract used in the present invention are, for example, obtained from the respective raw materials in a liquid or powder form by solvent extraction, and then blended into skin cosmetics or skin external preparations. Alternatively, any of a plurality of raw materials or intermediate processed products may be mixed in a suitable solvent to obtain an extract and used.

[0011] The antler reishi (or ganoderma lucidum) extract used in the present invention can be obtained as an aqueous solution by, for example, adding purified water to dried antler reishi (or ganoderma lucidum) powder or crushed matter, appropriately heating or boiling, stirring for several tens of minutes to several hours, and then centrifuging to collect the supernatant or filtering to remove solids, etc. The solvent can be removed once to obtain a powder, which can then be redissolved when in use.

[0012] The Siberian larch wood extract used in the present invention is prepared, for example, by adding an appropriate amount of hydrous alcohol to Siberian larch wood, stirring for several to 24 hours, and then centrifuging to collect the supernatant or filtering to remove the solids, and then removing the solvent with an evaporator or the like to obtain the solids. The extract is dissolved in a polar or non-polar solvent depending on the final formulation. A surfactant or the like is used as appropriate.

[0013] The sake lees extract used in the present invention is obtained as an aqueous solution by, for example, adding purified water to sake lees, stirring for about 30 minutes to 3 hours, and then centrifuging to collect the supernatant or filtering to remove solids, etc. Neutral conditions are preferable during stirring, and a buffer can be used to maintain neutral conditions.

[0014] The above-mentioned sake lees extract solution can be used as it is in the present invention, but a further process may be added to the solution to obtain a precipitate, such as by adding a salt such as ammonium sulfate. For example, ammonium sulfate may be gradually added to the solution while stirring until the solution is saturated, and then the solution is centrifuged to obtain a precipitate.

[0015] The above solutions of antler reishi extract, Siberian larch wood extract and sake lees extract can be mixed as is to form the skin cosmetic or topical skin preparation of the present invention, but various ingredients that can be blended and used in skin cosmetic or topical skin preparations can also be added appropriately to form various dosage forms and for various purposes. Whatever other ingredients are blended, they are all included in the scope of the present invention as long as the effects of the present invention are ultimately obtained.

[0016] The composition of the present invention is in a form for parenteral use (external use). It can be prepared in the form of parenteral cosmetics, quasi-drugs, medicines, skin external preparations, etc. Regardless of the use, the composition of the present invention can be a melanin production inhibitor, antioxidant, anti-inflammatory drug, cell protection drug, etc. due to the known effects of Ganoderma lucidum (deer antler Ganoderma lucidum) extract, Siberian larch tree extract, and sake lees extract.

[0017] The specific compositions of the present invention are described in more detail below by application. In applications such as cosmetics, the compositions can be used in a wide range of applications, including solutions, creams, milky lotions, skin toners, lotions, gels, essences (serums), packs and masks, ointments, bath additives, and other skin external preparations, including pharmaceuticals and quasi-drugs.

[0018] Cosmetics can also take a wide variety of formulations, including solutions, solubilized systems, emulsions, powder dispersions, gels, ointments, aerosols, water-oil two-layer systems, and water-oil-powder three-layer systems.

[0019] The amount of the antler reishi extract, Siberian larch wood extract and sake lees extract used in the present invention to be blended in the cosmetic or the like is preferably 0.0005 to 5% by weight, more preferably 0.002 to 2% by weight, and even more preferably 0.005 to 0.5% by weight, based on the total amount of the cosmetic, as the solid content of each component. The cosmetic of the present invention has the effect of retaining moisture in the skin, suppressing melanin production, suppressing inflammation, preventing rough skin, protecting the skin, conditioning the skin, and keeping the skin healthy, and can be used as an anti-inflammatory cosmetic, a cosmetic for preventing rough skin, protecting the skin, conditioning the skin, and keeping the skin healthy. In addition, the cosmetic of the present invention can be particularly preferably applied to applications as a skin external preparation, and can be used as a moisturizing skin external preparation, a melanin production suppressing skin external preparation, an anti-inflammatory skin external preparation, and a skin external preparation for preventing rough skin, protecting the skin, conditioning the skin, and keeping the skin healthy.

[0020] The ratio of the antler reishi extract, Siberian larch wood extract and sake lees extract used in the present invention in terms of solid content when blended into cosmetics and the like can be set arbitrarily depending on the possible range of the blending amount of each of the above-mentioned components. EXAMPLES

[0021] The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples.

[0022] Preparation Example 1 Deer antler reishi extract solution 50g of dried antler ganoderma lucidum powder was mixed with 1kg of purified water, heated to 90℃, gently stirred for 1 hour, and then filtered using filter paper. A part of the obtained filtrate was collected and the solid content was measured. A mixture of 1,2 hexanediol and 1,2 octanediol was added in advance to a final concentration of 2% to 5% by weight, and purified water was added to the remaining filtrate to dilute the antler ganoderma lucidum solid content to a final concentration of 0.5% by weight. The mixture was then sterilized by high-pressure steam to obtain solution 1 for storage. A part of solution 1 was mixed with 30% by weight of 1,3-butylene glycol aqueous solution in a ratio of 3 volumes of solution 1 to 7 volumes, and the mixture was used as sample 1 for Test Example 1.

[0023] Preparation Example 2 Siberian larch wood extract solution 0.5g of Siberian larch wood alcohol extract powder was added to an aqueous solution containing 10% to 30% by weight of ethanol and 30% to 50% by weight of 1,3-butylene glycol, dispersed uniformly using an appropriate dissolving agent, gently stirred at room temperature for 1 hour, and then purified water was added to a total weight of 1 kg and stirred. The resulting solution was filtered to remove any remaining insoluble matter, and further sterilized by high-pressure steam to obtain solution 2 for storage. A portion of solution 2 was used to add 30% by weight of 1,3-butylene glycol aqueous solution in a ratio of 3 volumes of solution 2 to 7 volumes, and mixed to obtain sample 2 used in Test Example 1.

[0024] Preparation Example 3 Sake lees extract solution 1 kg of purified water was added to 50 g of sake lees, uniformly dispersed, and stirred for 1 hour, after which an appropriate amount of diatomaceous earth was added and filtered using filter paper. A portion of the obtained filtrate was sampled to measure the solid content concentration, and 1,3-butylene glycol and purified water were appropriately added to obtain a 30% by weight 1,3-butylene glycol aqueous solution with a sake lees extract solid content of 0.5% by weight, filtered again, and then sterilized with high-pressure steam to obtain solution 3 for storage. A portion of solution 3 was used to add and mix a 30% by weight 1,3-butylene glycol aqueous solution in a ratio of 7 volumes to solution 3, and this was used as sample 3 for Test Example 1.

[0025] Preparation Example 4 Deer antler reishi extract, Siberian larch wood extract, sake lees extract mixed solution Equal volumes of solutions 1, 2, and 3 obtained in Preparation Examples 1, 2, and 3 were prepared and gently stirred to obtain a mixed stock solution. A part of the mixed stock solution was used to add 30% by weight of 1,3-butylene glycol aqueous solution in a ratio of 3 volumes of the mixed stock solution to 7 volumes of the same solution, and mixed. This mixed solution was used as Sample 4 to be used in Test Example 1.

[0026] Test Example 1 Panel Test Cosmetic compositions of sample 1, sample 2, sample 3 and sample 4 were tested and evaluated in a panel test by 10 panelists. Samples 1, 2, 3 and 4 were evaluated based on natural water as a standard. 0.3 mL of the standard natural water sample was taken in a pipette and dropped onto the back of either the left or right hand and spread evenly. Similarly, the same amount of samples 1 to 4 was dropped onto the back of the other hand with a pipette and spread evenly. After leaving it for 20 minutes, the panelists subjectively evaluated the following evaluation items based on the sensation of the backs of the left and right hands according to the criteria listed in Table 1. The evaluation was conducted by questionnaire. The results are shown in Table 2.

[0027] The evaluation items were set as follows: (A) Moisturizing (B) Hypoallergenic

[0028] A standard sample, X, is set, and sample Y is evaluated on the following five-point scale. [Table 1]

[0029] [Table 2]

[0030] Evaluation by score (Table 2 is expressed using the scores given in Table 1.) [Table 3]

[0031] As a result of the above test, as shown in Table 2, when the three ingredients, antler reishi extract, Siberian larch wood extract, and sake lees extract, were used together, the feeling of use was synergistically improved compared to when each ingredient was used alone. However, the extract solids concentration (sample 4 was the sum of the solids concentrations of each extract) was made the same for each sample.

[0032] Product Example 1 Toner The lotion having the following formulation can be prepared by a conventional method. Ingredients Amount (wt%) 1,3-Butylene glycol 6.0 Glycerin 3.5 Isostearyl alcohol 0.1 Sodium hyaluronate 0.2 POE(20) Sorbitan monolaurate 0.5 POE(20) Lauryl Ether 0.5 Ethanol 10.0 Mixture of antler reishi extract, Siberian larch wood extract and sake lees extract (mixture of Preparation Example 4) 10.0 Preservatives (appropriate amount) Antioxidant (appropriate amount) Fragrance (appropriate amount) Purified water remainder

Claims

1. A composition containing an extract of Ganoderma lucidum or antler Ganoderma lucidum, an extract of Siberian larch wood, and an extract of sake lees.

2. The skin cosmetic contains an extract of Ganoderma lucidum or staghorn Ganoderma lucidum, an extract of Siberian larch wood, and an extract of sake lees.

3. The skin external preparation contains an extract of Ganoderma lucidum or antler Ganoderma lucidum, an extract of Siberian larch wood, and an extract of sake lees.

Images