Liquid-filled combined container

Abstract

To reduce a decrement in amount of water included in a liquid while reducing the oxygen concentration of the liquid in a container.SOLUTION: A liquid-filled combined container comprises: a first container which contains a liquid including water at a storage part, and includes a transmission part having oxygen permeability; a second container which houses the first container and has oxygen barrier properties; and an oxygen absorber which absorbs oxygen in the second container. The steam permeation amount of the first container is 2.75 (mg / day) or less in an atmosphere of 20°C in temperature and 85% RH in humidity. The humidity in the second container is maintained at 80% RH or higher.SELECTED DRAWING: Figure 1A

Description

[Technical field]

[0001] The present disclosure relates to a liquid-containing combination container. [Background technology]

[0002] Containers for storing liquids are known (for example, Patent Document 1). Depending on the type of liquid, the liquid may be decomposed by oxygen inside the container. To address this problem, it may be possible to carry out a process for reducing the oxygen concentration of the liquid inside the container. For example, the oxygen concentration inside the container and the oxygen concentration of the liquid stored in the container can be reduced by nitrogen bubbling. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2011-212366 A Summary of the Invention [Problem to be solved by the invention]

[0004] There is a demand for reducing the amount of water lost from the liquid while reducing the oxygen concentration of the liquid in the container. In particular, when the liquid contained in the container is a medicine, there is a demand for reducing the amount of water lost from the medicine. The present disclosure aims to reduce the amount of water lost from the liquid while reducing the oxygen concentration of the liquid in the container. [Means for solving the problem]

[0005] One embodiment of the present disclosure relates to the following [1] to

[14] .

[0006] [1] A first container that contains a liquid including water in a container portion and includes a permeation portion having oxygen permeability; a second container that houses the first container and has oxygen barrier properties; an oxygen absorbent that absorbs oxygen in the second container; The water vapor transmission rate of the first container is 2.75 (mg / day) or less in an atmosphere having a temperature of 20° C. and a humidity of 85% RH; A liquid-containing combination container, wherein the humidity in the second container is maintained at 80% RH or higher.

[0007] [2] The liquid-containing combination container according to [1], further comprising a water-donating agent that releases water into the interior of the second container.

[0008] [3] The liquid-containing combination container described in [2], wherein the water-donating agent is located outside the first container and inside the second container.

[0009] [4] The liquid-containing combination container according to [2] or [3], wherein the water-donating agent releases water into the second container in an atmosphere having a temperature of 20° C. and a humidity of 80% RH.

[0010] [5] The liquid-containing combination container described in any one of [2] to [4], wherein the water-donating agent increases the humidity inside the second container by 1% RH or more when the atmosphere inside the second container is left for 6 hours at a temperature of 20°C and a humidity of 80% RH.

[0011] [6] The liquid-containing combination container according to any one of [1] to [5], wherein the liquid is a pharmaceutical product.

[0012] [7] The liquid-containing combination container according to any one of [1] to [6], wherein B2 (mg / day), which is the mass per day of water vapor that passes through the first container and moves from the inside to the outside of the first container when the amount of water vapor inside the second container has reached equilibrium, is 0.14 (mg / day) or less.

[0013] [8] The liquid-containing combination container according to any one of [1] to [7], wherein the elapsed time DA (days) from an initial state in which the temperature is 20°C, the humidity inside the first container is 100% RH, and the humidity inside the second container and the humidity outside the second container are 40% RH, until the amount of water vapor inside the second container reaches equilibrium is 3 (days) or less.

[0014] [9] DA (days) is the time elapsed from an initial state in which the temperature is 20° C., the humidity inside the first container is 100% RH, and the humidity inside the second container and the humidity outside the second container are 40% RH until the amount of water vapor inside the second container reaches equilibrium; A mass E (mg) of water vapor that passes through the first container and moves from the inside to the outside of the first container during an elapsed time DA (days) from the initial state; A liquid-containing combination container according to any one of [1] to [8], wherein B1 (mg / day), which is the mass per day of water vapor that passes through the first container and moves from the inside to the outside of the first container when the amount of water vapor inside the second container has reached equilibrium, satisfies the following formula (1).

number

[0015]

[10] The water vapor permeability of the second container is 15(g / (m) at a temperature of 40° C. and a humidity of 90% RH. 2 The liquid-containing combination container according to any one of [1] to [9], wherein the liquid-containing combination container is a container having a temperature of 100° C. or less.

[0016]

[11] The combination container containing liquids according to any one of [1] to

[10] , wherein the water vapor transmission rate of the first container is 5.4 (mg / day) or less in an atmosphere at a temperature of 40° C. and a humidity of 90% RH.

[0017]

[12] The first container has a container body having an opening, and a plug that closes the opening and forms the transmission section. The liquid-containing combination container described in any one of [1] to

[11] .

[0018]

[13] The liquid-containing combination container according to

[12] , wherein the stopper contains silicone. Effect of the Invention

[0019] According to the present disclosure, it is possible to reduce the oxygen concentration in the liquid in a container while minimizing the amount of water lost in the liquid. [Brief description of the drawings]

[0020] [Figure 1A] FIG. 1A is a diagram for explaining an embodiment according to the present disclosure, and is a front view showing an example of a combination container containing liquids. [Figure 1B] FIG. 1B is a vertical cross-sectional view showing the liquid-containing combination container shown in FIG. 1A. [Figure 1C] FIG. 1C is a vertical cross-sectional view showing an example of a first container containing liquid that can be included in the combination container containing liquid shown in FIG. 1A. [Figure 1D] FIG. 1D is a diagram showing a modified example of the sealing portion of the liquid-containing combination container shown in FIG. 1A. [Diagram 2] FIG. 2 is a vertical cross-sectional view showing a method for measuring the oxygen transmission rate in a portion of a container. [Figure 3A] FIG. 3A is a vertical cross-sectional view showing a method for measuring the water vapor transmission rate of a container. [Figure 3B] FIG. 3B is a vertical cross-sectional view showing a method for measuring the water vapor transmission rate of a container. [Figure 4A] FIG. 4A is a front view showing an example of the second container. [Figure 4B] FIG. 4B is a front view showing another example of the second container. [Figure 4C] FIG. 4C is a perspective view showing still another example of the second container. [Figure 4D]FIG. 4D is a perspective view showing still another example of the second container. [Figure 4E] FIG. 4E is a perspective view showing still another example of the second container. [Figure 4F] FIG. 4F is a perspective view showing still another example of the second container. [Diagram 5] FIG. 5 is a cross-sectional view showing an example of an oxygen absorbent. [Figure 6] FIG. 6 is a cross-sectional view showing an example of an oxygen absorbing film containing an oxygen absorbent. [Figure 7A] FIG. 7A is a diagram showing an example of a method for manufacturing the combination liquid-containing container and the first liquid-containing container shown in FIGS. 1A to 1C. [Figure 7B] FIG. 7B is a diagram showing an example of a method for manufacturing the combination liquid-containing container and the first liquid-containing container shown in FIGS. 1A to 1C. [Figure 7C] FIG. 7C is a diagram showing an example of a method for manufacturing the combination container containing liquid and the first container containing liquid shown in FIGS. 1A to 1C. [Figure 8] FIG. 8 is a diagram showing a method of using the first container containing liquid of FIG. 1C. [Figure 9] FIG. 9 is a diagram showing the movement of water in the liquid-containing combination container shown in FIGS. 1A to 1C. [Figure 10] FIG. 10 is a plan view showing an example of a fixing device in a modified example. [Figure 11] FIG. 11 is a cross-sectional view showing the fixture shown in FIG. 10 taken along line XI-XI. [Figure 12] FIG. 12 is a plan view showing an example of a fixing device in a modified example. [Figure 13] FIG. 13 is a cross-sectional view showing the fixture shown in FIG. 12 taken along line XIII-XIII. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0021] Hereinafter, an embodiment of the present disclosure will be described with reference to the drawings. In the drawings attached to this specification, the scale and aspect ratios are appropriately changed and exaggerated from those of the actual objects for the convenience of illustration and understanding. Configurations shown in some drawings may be omitted in other drawings. In the following description and the drawings used in the following description, the same reference numerals are used for parts that may be configured in common between the illustrated examples, and duplicated descriptions are omitted.

[0022] In this specification, terms that specify shapes or geometric conditions and their degrees, such as "parallel," "orthogonal," and "same," as well as values ​​of lengths and angles, are not limited to their strict meanings, but are interpreted to include a range within which similar functions can be expected.

[0023] In this specification, when multiple upper limit candidates and multiple lower limit candidates are given for a certain parameter, the numerical range of the parameter may be formed by combining any one of the upper limit candidates and any one of the lower limit candidates. As an example, consider the description "Parameter B may be A1 or more, A2 or more, or A3 or more. Parameter B may be A4 or less, A5 or less, or A6 or less." In this example, the numerical range of parameter B may be A1 or more and A4 or less, A1 or more and A5 or less, A1 or more and A6 or less, A2 or more and A4 or less, A2 or more and A5 or less, A2 or more and A6 or less, A3 or more and A4 or less, A3 or more and A5 or less, or A3 or more and A6 or less.

[0024] "Restrain" means to hold back the realization or occurrence, etc., or to hinder the realization or occurrence, etc. "Restrain" means not only to completely prevent the realization or occurrence, etc., but also to reduce the possibility of the realization or occurrence, etc., or to make the realization or occurrence, etc., more difficult.

[0025] 1A to 9 are diagrams for explaining an embodiment of the present disclosure. The liquid-containing combination container 10L includes a first container 30 that contains a liquid L including water in a container portion 31, a second container 40 that contains the first container 30, and an oxygen absorbent 21. The liquid-containing first container 30L includes the first container 30 and the liquid L contained in the first container 30. The first container 30 includes a permeable portion 35 that has oxygen permeability. Oxygen can permeate the permeable portion 35 of the first container 30. The second container 40 has oxygen barrier properties. The second container 40 has a storage space S that can store the liquid-containing first container 30L. The liquid-containing combination container 10L includes the liquid-containing first container 30L and the second container 40, and the liquid-containing first container 30L is stored in the second container 40.

[0026] In the liquid-containing combination container 10L, the oxygen absorbent 21 absorbs oxygen in the second container 40. The oxygen absorbent 21 reduces the oxygen concentration (%) in the second container 40. The oxygen absorbent 21 maintains the oxygen concentration (%) in the second container 40 in a reduced state. Due to the reduced oxygen concentration in the second container 40, the oxygen in the first container 30 passes through the transmission section 35 of the first container 30 and moves from the first container 30 to the second container 40. Due to the movement of oxygen from the first container 30 to the second container 40, the amount of oxygen in the first container 30 decreases. The amount of oxygen in the first container 30 is maintained in a reduced state. As a result, the liquid-containing combination container 10L can suppress deterioration of the liquid L in the first container 30 due to oxygen.

[0027] The liquid L contained in the first container 30 is not particularly limited as long as it contains water. The liquid L may be deteriorated by oxygen. The liquid L may be a solution containing a solvent and a solute dissolved in the solvent. As an example, the liquid L contains water as a solvent. The liquid L is not limited to a liquid in the strict sense. The liquid L may be a suspension in which solid particles are dispersed. The liquid L as food may be tea, coffee, black tea, soup, broth, or a concentrated liquid obtained by concentrating one or more of these. The liquid L may be a medicine. In particular, the liquid L may be a pharmaceutical product. The liquid L as a pharmaceutical product may be an internal medicine, an external medicine, or an injection. In addition to food and pharmaceutical products, the liquid L may be blood or a body fluid.

[0028] The liquid L is contained in the first container 30. The portion of the first container 30 in which the liquid L is contained is referred to as the container section 31. The volume of the liquid L contained in the first container 30 is smaller than the volume of the first container 30. Therefore, the liquid L contacts a part of the container section 31. When the first container 30 is left stationary, the area of ​​the container section 31 that contacts the liquid L is referred to as the contact area 31a. The state in which the first container 30 is left stationary includes a state in which the first container 30 is arranged so that the liquid level of the liquid L is stable for a predetermined time. As an example, the first container 30 is designed in advance so that the liquid level of the liquid L is stable for a predetermined time by arranging it in a specific orientation. In this case, the state in which the first container 30 is left stationary includes a state in which the first container 30 is arranged in the specific orientation. The state in which the first container 30 is upright is, for example, a state in which the first container 30 is stably arranged on a horizontal placement surface. In the case where the first container 30 includes a container body 32 having an opening 33 as described below, the state where the first container 30 is upright may be a state where the opening 33 side of the container body 32 is facing upward. For example, in FIG. 1A, the contact area 31a is a state where the opening 33 side of the container body 32 is facing upward. The state where the first container 30 is left stationary includes a state where the first container 30 is upright, and also includes a state where the first container 30 is arranged so that the liquid level of the liquid L contained in the container section 31 is stable, other than the state where the first container 30 is upright. For example, the state where the first container 30 is left stationary may include a state where the opening 33 side of the container body 32 is facing sideways, and a state where the opening 33 side of the container body 32 is facing obliquely upward. The state where the first container 30 is left stationary includes a state where the liquid level of the liquid L is stabilized by supporting the first container 30 by the second container 40. The state in which the first container 30 is left stationary includes a state in which the liquid level of the liquid L is stabilized by supporting the first container 30 by a member other than the second container 40. The state in which the first container 30 is left stationary includes a state in which the liquid level of the liquid L is stabilized by suspending the first container 30. A space in which gas can be contained, which is generated above a contact region 31a in contact with the liquid L, in the storage section 31 of the first container 30, is referred to as a head space HS.

[0029] Hereinafter, a detailed description will be given of an embodiment of the liquid-containing combination container 10L with reference to a specific example shown in Figures 1A and 1B. Figure 1A is a front view showing a specific example of the liquid-containing combination container 10L. Figure 1B is a vertical cross-sectional view showing the liquid-containing combination container 10L shown in Figure 1A.

[0030] As described above, the liquid-containing first container 30L includes the first container 30 and the liquid L contained in the first container 30. The first container 30 has oxygen permeability. The first container 30 can seal the liquid L. The first container 30 is permeable to oxygen but impermeable to the liquid L.

[0031] The first container 30 may further be an airtight container. Airtight means a container from which no gas leakage is detected by the liquid immersion method specified in JIS Z2330:2012. More specifically, a container that can prevent air bubbles from leaking when the container containing gas is immersed in water is judged to be an airtight container. Also, an airtight container is judged to be in an airtight state when no air bubbles are confirmed to leak from the container when the container containing gas is immersed in water. In the liquid immersion test, the container to be tested is immersed to a depth of 10 cm to 30 cm below the water surface. The presence or absence of air bubbles is judged by visual observation for 10 minutes.

[0032] The inside of the first container 30 may be in a sterile state. The liquid L may be a liquid that should be maintained in a sterile state. The liquid L that should be maintained in a sterile state may be highly sensitive. A highly sensitive liquid L is easily deteriorated by post-sterilization (also called final sterilization) performed after production. Post-sterilization cannot be applied to a highly sensitive liquid. Examples of post-sterilization include high-pressure steam, dry heat, radiation, ethylene oxide gas, and hydrogen peroxide gas plasma. A highly sensitive liquid L means a liquid in which 5% or more of the weight percentage of all medicinal ingredients contained in the liquid L is decomposed by post-sterilization of the liquid L, and one or more active ingredients contained in the liquid are decomposed by 1% or more by weight by post-sterilization of the liquid L. A highly sensitive liquid L to which post-sterilization cannot be applied may be manufactured using a manufacturing line arranged in a sterile environment. That is, a highly sensitive liquid L may be manufactured by an aseptic operation method. Examples of highly sensitive liquid L include anticancer drugs, antiviral drugs, vaccines, and antipsychotic drugs.

[0033] In order to adjust the amount of oxygen in the liquid L produced by a sterile process, the entire space in which the production line for the liquid L is located can be replaced with an inert gas. However, filling the entire space in which the production line for the liquid L is located with an inert gas atmosphere requires a huge capital investment and may also raise safety concerns for workers. In view of the above, the adjustment of the amount of oxygen in the liquid L has generally been left to replacing the atmosphere in the first container containing the liquid L with an inert gas, bubbling the liquid L with an inert gas, or the like.

[0034] In contrast, according to an embodiment described below, the first container 30L containing the liquid is accommodated in the second container 40, and an oxygen absorbent 21 is used to absorb the oxygen in the second container 40, thereby making it possible to sufficiently reduce the oxygen concentration in the second container 40. On the contrary, the oxygen concentration (%) in the first container 30 can be sufficiently reduced in a short period of time, and furthermore, the amount of dissolved oxygen (mg / L) in the liquid L can be sufficiently reduced. As an example, the amount of dissolved oxygen in the liquid L can be reduced to less than 0.15 mg / L, 0.04 mg / L or less, 0.03 mg / L or less, 0.02 mg / L or less, or even less than 0.015 mg / L.

[0035] Products (liquid L) labeled as "sterile" or "aseptic" and the inside of containers that contain such products, as well as pharmaceutical products (liquid L) and the inside of containers that contain such products, for which "aseptic" is a condition for commercialization, fall under the "sterile state" used in this specification. -6 A product (liquid L) that fills the container and the inside of the container that contains the product also fall under the "sterile state" as used in this specification. A product that does not grow bacteria when stored for four weeks at room temperature (e.g., 20°C) or higher and the inside of a container that contains the product also fall under the "sterile state" as used in this specification. A product that does not grow bacteria when stored for eight weeks or more in a refrigerated state (e.g., 8°C or lower) and the inside of a container that contains the product also fall under the "sterile state" as used in this specification. A drug that does not grow bacteria when stored for two weeks at a temperature between 28°C and 32°C and the inside of a container that contains the drug also fall under the "sterile state" as used in this specification.

[0036] The first container 30 includes a permeable portion 35 having oxygen permeability. The permeable portion 35 is a portion of the container that allows oxygen to pass through the container when oxygen can pass through the container at a predetermined oxygen permeation rate or more and move between the inside and outside of the container in an atmosphere having a temperature of 23° and a humidity of 40% RH. The predetermined oxygen permeation rate is 1×10 -1 The predetermined oxygen permeation amount is 1 (mL / (day×atm)) or more, 1.2 (mL / (day×atm)) or more, or 5 (mL / (day×atm)) or more. According to the first container 30 having the permeation section 35, the amount of oxygen in the first container 30 can be adjusted by oxygen permeation in the permeation section 35 of the first container 30. A method for measuring the oxygen permeation amount (mL / (day×atm)) that permeates a portion of the container will be described later.

[0037] Any of the above-mentioned lower limits of oxygen transmission rate may be combined with any of the above-mentioned upper limits of oxygen transmission rate to define a range of oxygen transmission rates.

[0038] The oxygen permeability coefficient of the material constituting the permeable portion 35 of the first container 30 is 1×10 -12 (cm 3 (STP)·cm / (cm 2 sec Pa) or more, 5×10 -12 (cm 3 (STP)·cm / (cm 2 sec Pa) or more, 1×10 -11 (cm 3 (STP)·cm / (cm 2 .·sec·Pa) or more. By setting a lower limit on the oxygen permeability coefficient, oxygen permeation in the permeation section 35 of the first container 30 is promoted, and the oxygen concentration in the first container 30 can be quickly adjusted. When the permeation section 35 includes multiple layers, the material constituting at least one of the layers may have the above oxygen permeability coefficient, or the materials constituting all of the layers may have the above oxygen permeability coefficient.

[0039] When the measurement object is a film or sheet-like member, the oxygen permeability coefficient is a value measured using an OXTRAN (2 / 21), a permeability measuring device manufactured by MOCON, USA, in an environment of 23°C temperature and 40% RH in accordance with JIS K7126-2:2006. When the measurement object is a container having a three-dimensional shape or a part of a container having a three-dimensional shape, the oxygen permeability coefficient is a value measured in accordance with ASTM D3985. The oxygen permeability coefficient is a value measured using an OXTRAN (2 / 61), a permeability measuring device manufactured by MOCON, USA, in an environment of 23°C temperature and 40% RH.

[0040] All gases may be able to permeate through the permeation section 35. Alternatively, only some gases including oxygen may be able to permeate through the permeation section 35.

[0041] The first container 30 may have oxygen permeability by having the entire first container 30 be the oxygen permeable permeable portion 35. The first container 30 may have oxygen permeability by having only a portion of the first container 30 be the oxygen permeable permeable portion 35.

[0042] As shown in FIG. 1C , the first container 30 may have a container body 32 and a stopper 34. The container body 32 has an opening 33. The stopper 34 may be held in the opening 33. The stopper 34 closes the opening 33. The stopper 34 regulates leakage of the liquid L from the opening 33. The stopper 34 may close the opening 33 airtightly. The stopper 34 may form a transmission portion 35. In this embodiment, unless otherwise specified, a case will be described in which the stopper 34 forms the transmission portion 35.

[0043] The permeation section 35 can promote oxygen permeation through the permeation section 35 when the permeation section 35 is not in contact with the liquid L. When the stopper 34 forms the permeation section 35 in the first container 30 including the container body 32 and the stopper 34, in a normal state (a state in which the above-mentioned first container 30 is upright), the stopper 34 is separated from the liquid L contained in the container body 32. That is, in a normal storage state of the first container 30, the stopper 34 can promote oxygen permeation through the stopper 34 of the first container 30. In this regard, by imparting oxygen permeability to the stopper 34, the amount of oxygen in the first container 30 can be quickly adjusted.

[0044] The plug 34, which is the oxygen permeable portion 35, has the above-mentioned oxygen permeability coefficient (cm 3 (STP)·cm / (cm 2 The plug 34 may be formed of a material having an oxygen permeability of 0.1·sec·Pa). The oxygen permeability coefficient of the material constituting the plug 34 may be greater than the oxygen permeability coefficient of the material constituting the container body 32. A portion of the plug 34 may be oxygen permeable. A portion of the plug 34 may be oxygen permeable throughout its entire thickness. The plug 34 may be oxygen permeable throughout its entire thickness in a central portion away from the periphery, and have oxygen barrier properties in a peripheral portion surrounding the central portion.

[0045] For example, the configuration of the oxygen-permeable portion of the first container 30 may be determined so that by storing the first container 30 containing a liquid with an oxygen dissolution rate of 8 mg / L in the second container 40 for four weeks, the oxygen concentration (%) in the first container 30 can be reduced by 5% or more.

[0046] The plug 34 is not particularly limited and may have various configurations. In the example shown in FIG. 1C, the plug 34 is inserted into the opening 33 of the container body 32 to close the opening 33. The plug 34 shown in FIG. 1C includes a plate-shaped plate portion 34a and an insertion protrusion 34b extending from the plate portion 34a. The insertion protrusion 34b is, for example, cylindrical. A plurality of insertion protrusions 34b may be provided on the circumference. The insertion protrusion 34b is inserted into the opening 33. The plate portion 34a includes a flange portion extending radially outward from the insertion protrusion 34b. The flange portion of the plate portion 34a is placed on the head 32d of the container body 32. The plug 34 may include an outer spiral or an inner spiral. The plug 34 may be attached to the container body 32 by the meshing of the spirals.

[0047] The plug 34 may contain silicone (a compound having a main skeleton formed by siloxane bonds). The plug 34 may be formed only from silicone. A portion of the plug 34 may be formed from silicone. The silicone contained in the plug 34 is solid in an environment in which the first container 30 is planned to be used. The silicone contained in the plug 34 does not need to contain silicone that becomes liquid in a room temperature environment, such as silicone oil. Silicone is a substance whose main chain is a siloxane bond. The plug 34 may be formed from a silicone elastomer. The plug 34 may be formed from silicone rubber.

[0048] Silicone rubber refers to a rubber-like material made of silicone. Silicone rubber is a synthetic resin whose main component is silicone, and is a rubber-like material. Silicone rubber is a rubber-like material whose main chain is a siloxane bond. Silicone rubber may be a thermosetting compound containing a siloxane bond. Examples of silicone rubber include methyl silicone rubber, vinyl-methyl silicone rubber, phenyl-methyl silicone rubber, dimethyl silicone rubber, and fluoro silicone rubber.

[0049] The oxygen permeability coefficient of silicone and silicone rubber is 1×10 -12 (cm 3 (STP)·cm / (cm2 sec Pa) or more, 1×10 -11 (cm 3 (STP)·cm / (cm 2 The oxygen permeability coefficient of silicone and the oxygen permeability coefficient of silicone rubber are 1×10 -9 (cm 3 (STP)·cm / (cm 2 ·sec·Pa) or less. Compared with natural rubber, silicone and silicone rubber have a hydrogen permeability coefficient about 10 times, an oxygen permeability coefficient about 20 times, and a nitrogen permeability coefficient about 30 times. Compared with butyl rubber, silicone and silicone rubber have a hydrogen permeability coefficient 70 times or more, an oxygen permeability coefficient 40 times or more, and a nitrogen permeability coefficient 650 times or more.

[0050] At least a portion of the plug 34 may be made of silicone. That is, the whole or a part of the plug 34 may be made of silicone or silicone rubber. For example, a part of the plug 34 may be made of silicone or silicone rubber over its entire thickness. The part may be a central part of the plug 34, or a part or the whole of a peripheral part surrounding the central part.

[0051] As shown in Fig. 1C, the container body 32 may include a bottom 32a, a body 32b, a neck 32c, and a head 32d, in this order. As shown in Fig. 1C, a storage space S for a liquid L is formed mainly by the bottom 32a and the body 32b. The head 32d forms the tip of the container body 32. The head 32d is thicker than the other parts. The neck 32c is located between the body 32b and the head 32d. The neck 32c is narrower in width, particularly narrower in diameter, than the body 32b and the head 32d.

[0052] The oxygen permeability coefficient of the material constituting the container body 32 may be smaller than the oxygen permeability coefficient of the material constituting the stopper 34. The container body 32 may have oxygen barrier properties. That is, the first container 30 may have oxygen permeability only in a portion. The oxygen permeability coefficient of the material constituting the portion of the first container 30 having oxygen barrier properties is 1×10 -13 (cm 3 (STP)·cm / (cm 2 sec Pa) or less, and 1×10 -17 (cm 3 (STP)·cm / (cm 2 ·sec·Pa) or less is also acceptable.

[0053] The container body 32 may be transparent. A transparent container body 32 allows the contained liquid L to be observed from the outside of the container body 32. Transparent means that the visible light transmittance is 50% or more, and preferably 80% or more. The visible light transmittance is specified as the average value of the transmittance at each wavelength when measured at an incident angle of 0° at every 1 nm within a measurement wavelength range of 380 nm to 780 nm using a spectrophotometer (Shimadzu Corporation's "UV-3100PC", compliant with JIS K 0115).

[0054] The first container 30 shown in FIG. 1C further includes a fixing device 36. The fixing device 36 prevents the plug 34 from coming off the container body 32. The fixing device 36 is attached to the head 32d of the container body 32. As shown in FIG. 1C, the fixing device 36 covers the periphery of the plate-shaped portion 34a of the plug 34. The fixing device 36 presses the flange portion of the plate-shaped portion 34a toward the head 32d. As a result, the fixing device 36 prevents the plug 34 from coming off the container body 32 while exposing a portion of the plug 34. In addition, the fixing device 36 can make the gap between the plug 34 and the container body 32 liquid-tight and airtight. The fixing device 36 puts the first container 30 in an airtight state. The fixing device 36 may be a sheet-shaped metal fixed to the head 32d. The fixing device 36 may be a cap screwed to the head 32d. The metal fixing device 36 may have oxygen barrier properties. The fixture 36 may be a cap made of a resin lid and an aluminum member.

[0055] The volume of the first container 30 may be 1 mL or more, 3 mL or more, or 5 mL or more. The volume of the first container 30 may be 200 mL or less, 100 mL or less, 50 mL or less, 30 mL or less, or 20 mL or less.

[0056] The area of ​​the opening 33 of the first container 30, i.e., the opening area of ​​the container body 32, is 1 mm 2 More than 10mm is fine. 2 More than 30mm is fine. 2 The thickness of the stopper 34 may be 3 mm or less, or 1 mm or less. This promotes oxygen permeation through the first container 30, and allows the oxygen concentration in the first container 30 to be adjusted quickly. The stopper 34 can be pierced with a syringe needle. Furthermore, from the viewpoint of being able to be pierced with a straw, the thickness of the stopper 34 may be 0.1 mm or less. In this case, the stopper 34 may be a film-like stopper.

[0057] The area of ​​the opening 33 is 5000 mm 2 The thickness of the plug 34 may be 0.01 mm or more. This can suppress leakage of water vapor and the like, and can suppress the effect on the liquid in the first container 30 after the second container 40 is opened due to a high oxygen transmission rate. The range of the area of ​​the opening may be determined by combining the upper limit of the area of ​​the opening with any of the lower limits of the area of ​​the opening described above. The range of the thickness of the plug 34 may be determined by combining the lower limit of the thickness of the plug 34 with any of the upper limits of the thickness of the plug 34 described above.

[0058] The first container 30 shown in FIG. 1C is a vial. The container body 32 of the first container 30 may be a glass bottle. The glass bottle is a container made of glass. The glass bottle may be colorless or colored. The container body 32 is formed of, for example, borosilicate glass. The container body 32, which is a glass bottle, may have oxygen barrier properties and water vapor barrier properties. A vial is a container that includes a container body, a stopper inserted into the opening of the container body, and a seal as a fixing device 36 for fixing the stopper, and the seal is crimped to the head of the container body together with the stopper using a hand gripper or the like. The volume of the first container 30, which is a vial, may be 1 mL or more, or 3 mL or more. The volume of the first container 30, which is a vial, may be 200 mL or less, 100 mL or less, 50 mL or less, 30 mL or less, or 20 mL or less.

[0059] When the first container 30 is a vial, the oxygen permeability coefficient of the material constituting the stopper 34 may be greater than the oxygen permeability coefficient of the glass constituting the container body 32. By separating the oxygen permeable portion of the first container 30 from the liquid L, the movement of oxygen from inside the first container 30 to outside the first container 30 can be promoted. The first container 30, which is a vial, can be stably placed on the mounting surface by contacting the bottom 32a of the container body 32 with the mounting surface. That is, in the first container 30, which is a vial, the state in which the bottom 32a of the container body 32 is in contact with the mounting surface corresponds to the above-mentioned state in which the first container 30 is upright. At this time, the stopper 34 is separated from the liquid L. The stopper 34 does not come into contact with the liquid L. Therefore, in the normal storage state of the first container 30, oxygen permeation through the stopper 34 of the first container 30 can be promoted.

[0060] An upper limit may be set for the oxygen transmission rate permeating the permeation section 35 of the first container 30. By setting an upper limit, the rate at which water vapor or the like leaks from the first container 30 can be kept low. In particular, the rate at which water in the first container 30 permeates the permeation section 35 in the form of water vapor and leaks out of the first container 30 can be kept low. This makes it possible to further reduce the amount of water lost in the liquid L contained in the first container 30. By setting an upper limit, it is possible to suppress the influence on the liquid L in the first container 30 caused by the high gas transmission rate after the second container 40 is opened. The oxygen transmission rate permeating the permeation section 35 of the first container 30 may be 100 (mL / (day×atm)) or less, 50 (mL / (day×atm)) or less, or 10 (mL / (day×atm)) or less. The range of the oxygen transmission rate may be determined by combining any of the above-mentioned lower limits of the oxygen transmission rate with any of the above-mentioned upper limits of the oxygen transmission rate.

[0061] A lower limit may be set for the oxygen transmission rate of a portion of the first container 30 obtained by cutting the container body 32, the portion including the stopper 34 and the portion surrounding the stopper 34. For example, the oxygen transmission rate of a portion of the first container 30 obtained by cutting the container body 32, the portion including the stopper 34 and the portion surrounding the stopper 34, is 1×10 -1 (mL / (day×atm)) or more.

[0062] The amount of oxygen permeation (mL / (day×atm)) through a portion of a container can be measured using a test container 70 including the portion, as shown in FIG. 2. The test container 70 includes a partition wall 71. The test container 70 has an internal space partitioned by the partition wall 71. The partition wall 71 includes a portion of the container and a main wall 72 having oxygen barrier properties. The amount of oxygen permeation through the portion of the container is specified as the oxygen permeation (mL / (day×atm)) of the test container 70.

[0063] The oxygen concentration in the test container 70 is maintained at 0.05% or less. The test container 70 is connected to a first flow path 76 and a second flow path 77. The second flow path 77 is connected to an oxygen meter 79 that measures the amount of oxygen. The oxygen meter 79 can measure the amount of oxygen (mL) flowing through the second flow path 77. When the measurement target is a container having a three-dimensional shape or a part of a container having a three-dimensional shape, an oxygen meter used in OXTRAN (2 / 61) manufactured by MOCON, USA, can be used as the oxygen meter 79. The container having a three-dimensional shape includes a film container and a molded container. The first flow path 76 supplies gas into the test container 70. The first flow path 76 supplies a gas that does not contain oxygen. The first flow path 76 supplies an inert gas. The first flow path 76 supplies nitrogen. The second flow path 77 exhausts the gas in the test container 70. A state in which substantially no oxygen is present inside the test container 70 is maintained by the first flow path 76 and the second flow path 77. The oxygen concentration inside the test container 70 is maintained at 0.05% or less.

[0064] The test container 70 is placed in a test atmosphere having a temperature of 23° and a humidity of 40% RH. The oxygen concentration of the atmosphere in which the test container 70 is placed is higher than the oxygen concentration in the test container 70. The test atmosphere is an air atmosphere. The oxygen concentration of the air atmosphere is 20.95%. When the test container 70 is placed in the test atmosphere, oxygen moves from the test atmosphere into the test container 70 by passing through a portion 30X of the container. The gas in the test container 70 is discharged from the second flow path 77. By measuring the amount of oxygen flowing through the second flow path 77 with the oxygen meter 79, the daily oxygen transmission amount (mL / (day×atm)) passing through the portion 30X in an atmosphere having a temperature of 23° and a humidity of 40% RH can be measured.

[0065] In Fig. 2, the test container 70 is placed in a test chamber 78. The atmosphere in the test chamber 78 is maintained at a temperature of 23° and a humidity of 40% RH. Air is supplied into the test chamber 78 from a supply path 78A. Gas in the test chamber 78 is exhausted from an exhaust path 78B. Air is circulated by the supply path 78A and the exhaust path 78B, and the oxygen concentration in the test chamber 78 is maintained at 20.95%.

[0066] A pump for circulating air is provided in one of the supply path 78 A and the discharge path 78 B. The supply path 78 A and the discharge path 78 B are open to an air atmosphere under atmospheric pressure.

[0067] FIG. 2 shows a method for measuring the amount of oxygen transmission, taking the oxygen-permeable portion 30X of the first container 30 as an example. In FIG. 2, the partition wall 71 is composed of the oxygen-permeable portion 30X of the first container 30 and a main wall portion 72 having oxygen barrier properties. In FIG. 2, the partition wall portion 71 is composed of the portion 30X cut out from the first container 30 and a main wall portion 72 connected to the periphery of the portion 30X. The main wall portion 72 has a through hole 72A that exposes the portion 30X. In FIG. 2, the periphery of the through hole 72A and the portion 30Y adjacent to the portion 30X are airtightly joined. In FIG. 2, the portion 30Y adjacent to the portion 30X is airtightly joined to the periphery of the through hole 72A of the main wall portion 72 via a barrier bonding material 73. 2, a portion of the first container 30 shown in FIG. 1C near the stopper 34 is cut away. In this example, the stopper 34 is the oxygen-permeable portion 30X. The portions 32c and 32d forming the opening 33 of the container body 32 and the fastener 36 are hermetically connected to the main wall portion 72 via the barrier bonding material 73 as the portion 30Y adjacent to the oxygen-permeable portion 30X.

[0068] In FIG. 2, the container body 32 is cut at the neck portion 32c. The stopper 34 is compressed and held in the opening 33 formed by the head portion 32d of the container body 32. The fixing device 36 provides airtightness between the container body 32 and the stopper 34. The fixing device 36, which has oxygen barrier properties such as aluminum, partially covers the stopper 34. The container body 32 and the fixing device 36, which have oxygen barrier properties, are connected to the main wall portion 72 via a barrier bonding material 73. The stopper 34 is maintained in a state similar to that when the first container 30 is closed in actual use, such as compression in the opening 33 and tightening by the fixing device 36. Therefore, the oxygen transmission amount of the stopper 34 can be measured under the same conditions as those during actual use.

[0069] The method for measuring the oxygen permeation rate (mL / (day×atm)) through a portion of a container has been described above. The oxygen permeation rate (mL / (day×atm)) through the entire container can be determined by dividing the container into two or more portions and adding up the oxygen permeation rates measured for each portion. The oxygen permeation rate of the first container 30 shown in FIG. 2 can be determined by measuring the oxygen permeation rate of the container body 32 and adding up the oxygen permeation rate of the container body 32 and the oxygen permeation rate of the portion 30X measured by the method shown in FIG. 2. The oxygen permeation rate (mL / (day×atm)) of the container body 32 can be measured by using a test container 70 prepared by combining the container body 32 with a main wall portion 72.

[0070] Since the permeation portion 35 has oxygen permeability, it is considered that the water vapor permeation amount of the first container 30 having the permeation portion 35 is larger than a certain amount. A lower limit may be set for the water vapor permeation amount of the first container 30. As an example, the lower limit of the water vapor permeation amount of the first container 30 is set so that the water vapor permeation amount of the first container 30 is more than twice the water vapor permeation amount of a hypothetical container made of butyl rubber having the same shape as the first container 30. The water vapor permeation amount of the first container 30 is, for example, 0.05 (mg / day) or more in an atmosphere at a temperature of 20°C and a humidity of 85% RH. The water vapor permeation amount of the first container 30 may be 0.15 (mg / day) or more, or may be 0.75 (mg / day) or more in an atmosphere at a temperature of 20°C and a humidity of 85% RH. By setting a lower limit for the water vapor permeation amount of the first container 30, the oxygen permeation amount of the permeation portion 35 can be secured to be sufficiently large, and oxygen permeation through the permeation portion 35 can be promoted. On the other hand, if the water vapor permeability of the first container 30 is large, it is considered that the rate at which the water inside the first container 30 permeates the first container 30 in the form of water vapor and leaks out of the first container 30 increases.

[0071] In this embodiment, an upper limit is set for the water vapor transmission rate of the first container 30. The water vapor transmission rate of the first container 30 is 2.75 (mg / day) or less in an atmosphere at a temperature of 20° C. and a humidity of 85% RH. By setting the water vapor transmission rate of the first container 30 to 2.75 (mg / day) or less in an atmosphere at a temperature of 20° C. and a humidity of 85% RH, the rate at which water in the first container 30 permeates the first container 30 and leaks out of the first container 30 can be reduced. This makes it possible to reduce the amount of water contained in the liquid L contained in the first container 30 that is reduced within a predetermined time. The water vapor transmission rate of the first container 30 may be 1.80 (mg / day) or less, or 1.40 (mg / day) or less in an atmosphere at a temperature of 20° C. and a humidity of 85% RH. The range of the water vapor transmission rate may be determined by combining any of the above-mentioned lower limits of the water vapor transmission rate with any of the above-mentioned upper limits of the water vapor transmission rate.

[0072] The water vapor transmission rate (mg / day) of a container such as the first container 30 is measured by the following method when the container has a fixed three-dimensional shape. First, the container is cut so as to separate the container's storage section. One of the divided containers is referred to as the first part 381. The other of the divided containers, which is not the first part 381, is referred to as the second part 382. Next, as shown in FIG. 3A, calcium chloride 38d is accommodated in the part of the first part 381 that constituted the storage section of the container. Next, a sealing member 38b is placed on the opening 38a formed in the first part 381 by cutting the container, and the first part 381 and the sealing member 38b are bonded together using a water-resistant adhesive 38c. As a result, the opening 38a formed in the first part 381 is closed by the sealing member 38b and the adhesive 38c. The sealing member 38b is an aluminum plate or aluminum foil. Next, the first part 381 is left in a measurement environment for 10 days. When measuring the water vapor transmission rate of the first container 30 in an atmosphere with a temperature of 20°C and a humidity of 85%RH, for example, the temperature of the measurement environment is set to 20°C and the humidity is set to 85%RH. That is, the first portion 381 is left in an environment with a measurement temperature of 20°C and a humidity of 85%RH. Then, the total mass of the first portion 381, the sealing member 38b, the adhesive 38c, and the calcium chloride 38d is measured at a first time t1, which is included in the 10 days and at least one day after the first portion 381 is left, and at a second time t2, which is included in the 10 days and is seven days after the first time t1. The difference obtained by subtracting the total mass at the first time t1 from the total mass at the second time t2 can be regarded as the mass of water that has permeated the first portion 381 and been absorbed by the calcium chloride 38d during the seven days from the first time t1 to the second time t2. Therefore, the water vapor transmission rate (mg / day) of the first portion 381 is obtained by subtracting the total mass at the first time t1 from the total mass at the second time t2 and dividing the difference (mg) by 7 (days).

[0073] The water vapor transmission rate (mg / day) of the second portion 382 is measured by a method similar to that for measuring the water vapor transmission rate (mg / day) of the first portion 381. That is, as shown in FIG. 3B, the opening 38e formed in the second portion 382 is closed by a method similar to that for closing the opening 38a of the first portion 381. Next, the second portion 382 is left for 10 days. Then, the total mass of the second portion 382, ​​the sealing member 38b, the adhesive 38c, and the calcium chloride 38d is measured at a first time t1, which is included in the 10 days and at least one day after the second portion 382 is started to be left, and at a second time t2, which is included in the 10 days and is seven days after the first time t1. The difference obtained by subtracting the total mass at the first time t1 from the total mass at the second time t2 can be regarded as the mass of water that has permeated the second portion 382 and been absorbed by the calcium chloride 38d during the seven days from the first time t1 to the second time t2. Therefore, the water vapor transmission rate (mg / day) of the second portion 382 is obtained by subtracting the total mass at the first time t1 from the total mass at the second time t2 and dividing the difference (mg) by 7 (days).

[0074] The water vapor transmission rate (mg / day) through the container is calculated by adding up the water vapor transmission rate (mg / day) through the first portion 381 and the water vapor transmission rate (mg / day) through the second portion 382.

[0075] The first container 30 shown in FIG. 1C can maintain a negative internal pressure under atmospheric pressure. The first container 30 can contain a gas while maintaining the gas at a negative pressure under atmospheric pressure. The first container 30 may be capable of containing a gas while maintaining the gas at a positive pressure under atmospheric pressure. In these examples, the first container 30 may have sufficient rigidity to maintain its shape. However, the first container 30 may deform somewhat under atmospheric pressure when maintaining the internal pressure at a negative pressure or positive pressure. Examples of the first container 30 capable of maintaining a negative or positive internal pressure include the above-mentioned vial bottle and a can made of metal.

[0076] Capable of storing gas while maintaining a negative pressure under atmospheric pressure means that the gas can be stored without being damaged while maintaining the internal pressure at a negative pressure of 0.80 atm or more. The container capable of storing gas while maintaining a negative pressure under atmospheric pressure may be airtight when the internal pressure is 0.80 atm. The container capable of storing gas while maintaining a negative pressure under atmospheric pressure may be capable of maintaining a volume at 95% or more of the volume at 1.0 atm when the internal pressure is 0.80 atm. The container capable of storing gas while maintaining a positive pressure in the atmosphere means that the gas can be stored without being damaged while maintaining a positive internal pressure of 1.2 atm or less. The container capable of storing gas while maintaining a positive pressure under atmospheric pressure may be airtight when the internal pressure is 1.20 atm. The container capable of storing gas while maintaining a positive pressure under atmospheric pressure may be capable of maintaining a volume at 1.2 atm or less of the volume at 1.0 atm when the internal pressure is 105% or less of the volume at 1.0 atm when the internal pressure is 1.0 atm.

[0077] The first container 30 is intended to be housed in the second container 40. The first container 30 housed in the second container 40 may be able to house gas without breaking when the difference between the internal pressure of the first container 30 and the internal pressure of the second container 40 is 0.2 atm or less. The first container 30 housed in the second container 40 may be airtight when the difference between the internal pressure of the first container 30 and the internal pressure of the second container 40 is 0.2 atm or less. The first container 30 housed in the second container 40 may have a volume of 95% to 105% of the volume of the first container 30 when the internal pressure of the first container 30 is the same as the internal pressure of the second container 40 when the difference between the internal pressure of the first container 30 and the internal pressure of the second container 40 is 0.2 atm or less. In these states in which the first container 30 is housed in the second container 40, the internal pressure of the first container 30 may be lower than the internal pressure of the second container 40, or the internal pressure of the first container 30 may be higher than the internal pressure of the second container 40.

[0078] As an example of the first container 30, the above description has been given of a configuration having a container body 32 and a stopper 34, with the stopper 34 being the oxygen-permeable permeable portion 35. However, the configuration of the first container 30 is not limited to this. The first container 30 may have a container body 32 at least a portion of which is the oxygen-permeable permeable portion 35, and a stopper 34 having oxygen barrier properties.

[0079] The second container 40 has a volume capable of accommodating the first container 30. The second container 40 can be sealed by welding such as heat sealing or ultrasonic bonding, or by bonding using a bonding material such as an adhesive or bonding material. The second container 40 may be an airtight container. The volume of the second container 40 may be, for example, 5 mL or more and 1200 mL or less. When the first container 30 is a small container such as a vial, for example, a container with a volume of 1 mL or more and 20 mL or less, the volume of the second container may be 1.5 mL or more and 500 mL or less.

[0080] The second container 40 has oxygen barrier properties. A container has oxygen barrier properties when the oxygen permeability (mL / (m 2 × day × atm) is 10,000 or less. The oxygen permeability (mL / (m 2 ×day×atm)) may be 15 or less, 5 or less, 1 or less, 0.5 or less, or 0.1 or less. The oxygen permeability is measured in accordance with JIS K7126-2:2006 (isobaric method). The oxygen permeability is measured using an OXTRAN (2 / 21), a permeability measuring device manufactured by MOCON, USA, in an environment of 23°C temperature and 90% RH. For containers having oxygen barrier properties, the oxygen permeability (mL / (m 2 There is no particular lower limit for the oxygen permeability (mL / (m 2 × day × atm) may be 0.01 or more.

[0081] The oxygen permeability coefficient of the material constituting the second container 40 having oxygen barrier properties is 1×10 -13 (cm 3 (STP)·cm / (cm2 sec Pa) or less, and 1×10 -17 (cm 3 (STP)·cm / (cm 2 ·sec·Pa) or less is also acceptable.

[0082] Examples of the second container 40 having oxygen barrier properties include a can made of metal, a container having a metal layer formed by deposition or transfer, and a glass bottle. As shown in the example of FIG. 1A and FIG. 1B, the second container 40 may be a film container. The film container is a container made of film. The film constituting the film container may be a laminate including a layer having oxygen barrier properties. The laminate may include a resin layer having oxygen barrier properties such as ethylene-vinyl alcohol copolymer (EVOH) or polyvinyl alcohol (PVA), or a metal vapor deposition film. The second container 40 may include a transparent portion. A part of the second container 40 may be transparent. The entire second container 40 may be transparent. The second container 40 using a laminate and the second container 40 using glass or resin can be given transparency in addition to oxygen barrier properties. By giving transparency to the second container 40, the first container 30L containing the liquid contained therein can be confirmed from the outside of the second container 40.

[0083] In the example shown in FIG. 1A and FIG. 1B, the second container 40 is a film container. The second container includes a first film (first main film) 41a and a second film (second main film) 41b. The first film 41a and the second film 41b are arranged facing each other. The first film 41a and the second film 41b may be different films from each other. The first film 41a and the second film 41b may be a single film folded back as described later with reference to FIG. 4B and FIG. 4C. The first film 41a and the second film 41b are joined to each other at a linear seal portion 49. The joining at the seal portion 49 may be, for example, welding such as heat sealing or ultrasonic joining, or joining using an adhesive or bonding material. A storage space S for accommodating the first container 30 is formed between the first film 41a and the second film 41b.

[0084] The first film 41a and the second film 41b are capable of being peeled away at the sealed portion 49. When a user applies force to peel the first film 41a and the second film 41b away from each other, the first film 41a and the second film 41b are separated from each other at the sealed portion 49. The sealed portion 49 is made capable of being peeled away by adjusting the processing conditions during bonding and the material and thickness of the bonding material (sealant layer), etc.

[0085] The seal portion 49 includes a curved first seal portion 49a. The first container 30 accommodated in the second container 40 faces the first seal portion 49a. The first container 30 faces the first seal portion 49a in the first direction D1. The first seal portion 49a is curved so as to protrude toward a side away from the first container 30 in the first direction D1. The first seal portion 49a is curved so as to protrude toward the outside of the accommodation space S of the second container 40. The first seal portion 49a is curved so as to protrude toward a side that widens the accommodation space S of the second container 40.

[0086] In the illustrated example, the seal portion 49 includes a first side seal portion 49b connected to one end of the first seal portion 49a and a second side seal portion 49c connected to the other end of the first seal portion 49a. Between the first side seal portion 49b and the second side seal portion 49c, an accommodation space S for the second container 40 that accommodates the first container 30 is formed. The minimum distance DXa between the first side seal portion 49b and the second side seal portion 49c along the first film 41a may be shorter than the length L30 of the first container 30 along the direction in which the plug 34 is inserted into the opening 33. The minimum distance DXb between the first side seal portion 49b and the second side seal portion 49c along the second film 41b may be shorter than the length L30 of the first container 30 along the direction in which the plug 34 is inserted into the opening 33. In the illustrated example, the direction in which the plug 34 is inserted into the opening 33 is the same as the first direction D1 in which the first container 30 and the first seal portion 49a face each other.

[0087] The minimum distance DXa along the first film 41a between the first side seal portion 49b and the second side seal portion 49c is the minimum length of the first film 41a between the first side seal portion 49b and the second side seal portion 49c. The minimum distance DXb along the second film 41b between the first side seal portion 49b and the second side seal portion 49c is the minimum length of the second film 41b between the first side seal portion 49b and the second side seal portion 49c. The length L30 of the first container 30 is the axial length of the first container 30, and is usually the longitudinal length of the first container 30.

[0088] By making the minimum distance DXa, DXb along the films 41a, 41b between the side seal portions 49b, 49c shorter than the length L30 of the first container 30, it is possible to suppress a large change in the orientation of the first container 30 within the second container 40. In other words, the orientation of the first container 30 within the second container 40 is stabilized. As a result, as described below, the stopper 34 of the first container 30 and the oxygen reactant 20 including the oxygen absorbent 21 can be stably maintained in a face-to-face state, and the discharge of oxygen from the first container 30 can be promoted.

[0089] The seal portion 49 further includes a second seal portion 49d facing the first seal portion 49a in the first direction D1. In the illustrated example, the seal portion 49 includes the first seal portion 49a and the second seal portion 49d facing the first direction D1, and the first side seal portion 49b and the second side seal portion 49c facing the second direction D2. The seal portion 49 is formed in a circumferential shape by the first seal portion 49a, the second seal portion 49d, the first side seal portion 49b, and the second side seal portion 49c. The circumferential seal portion 49 defines the storage space S of the second container 40. Instead of the second seal portion 49d, a folded portion 41x formed by folding back a piece of film as shown in FIG. 4B described later may be provided.

[0090] As shown in FIG. 1A and FIG. 1B, the first film 41a and the second film 41b each include a main portion 50a forming the storage space S and an extension portion 50b connected to the main portion 50a. The main portion 50a includes a first seal portion 49a, a second seal portion 49d, a first side seal portion 49b, and a second side seal portion 49c, and a portion surrounded by these seal portions 49a, 49d, 49b, and 49c. The extension portion 50b is connected to the main portion 50a at the first seal portion 49a. The extension portion 50b may be connected to at least the curved top portion of the first seal portion 49a. The extension portion 50b may be connected to at least the portion of the first seal portion 49a that protrudes most from the first container 30 in the first direction D1 in which the first container 30 and the first seal portion 49a face each other. In the extension portion 50b, the space between the first film 41a and the second film 41b is open to the outside. In the extension portion 50b, the space between the first film 41a and the second film 41b is not sealed by a seal portion.

[0091] A user can easily apply a peeling force to the first film 41a and the second film 41b by grasping the extension portion 50b. At this time, the peeling force is concentrated at the top of the bend of the first sealed portion 49a. In the illustrated example, the peeling force is concentrated at the bent portion of the bent first sealed portion 49a. This allows the first film 41a and the second film 41b to be easily and smoothly peeled off starting from the bent first sealed portion 49a. In this second container 40, the first sealed portion 49a is the portion to be opened. The portion to be opened is a portion intended to be opened when the second container 40 is opened.

[0092] In the illustrated example, the second direction D2 is perpendicular to the first direction D1. The third direction D3 is perpendicular to both the first direction D1 and the second direction D2. The first film 41a and the second film 41b face each other in the third direction D3. The first film 41a and the second film 41b are rectangular in shape when laid out flat. The first film 41a and the second film 41b include a pair of edges extending in the first direction D1. The first film 41a and the second film 41b include a pair of edges extending in the second direction D2. The edges extending in the first direction D1 form the long sides of the rectangular shape. The edges extending in the second direction D2 form the short sides of the rectangular shape.

[0093] In order to clarify the relationship between directions between the drawings, common directions are indicated in several drawings by arrows with common symbols. The tip of the arrow is the first side of each direction. The opposite side of the arrow is the second side of each direction. An arrow pointing into the paper in a direction perpendicular to the paper surface of the drawing is indicated by a symbol of a cross in a circle, as shown in FIG. 1A, for example. An arrow pointing out of the paper in a direction perpendicular to the paper surface of the drawing is indicated by a symbol of a dot in a circle, as shown in FIG. 1B, for example.

[0094] When the second container 40 is a film container, the material of the second container 40 may be a general material used for film containers. The second container 40 may contain at least one of acrylic resin and polyethylene terephthalate resin. In this case, the first film 41a and the second film 41b of the second container 40 may contain at least one of acrylic resin and polyethylene terephthalate resin. When the second container 40 includes a laminate including a resin layer, the resin layer may include either one or both of acrylic resin and polyethylene terephthalate resin. In this case, the first film 41a and the second film 41b of the second container 40 may include a laminate including a resin layer.

[0095] The second container 40 is not limited to the example shown in Figures 1A and 1B. As shown in Figure 4A, a seal portion 49 may be joined at the periphery of the films 41a and 41b.

[0096] Instead of joining separate films, the films 41a and 41b may be formed from a single folded film. The two films 41a and 41b may be formed from a single seamless film.

[0097] The second container 40 shown in FIG. 4B includes a film 41 folded at a fold portion 41x. The second container 40 can be produced by joining the facing portions of the folded film 41 at a seal portion 49. In the second container 40 shown in FIG. 4B, a storage space S is formed in a portion surrounded by the fold portion 41x and the three-sided seal portion 49. In the example shown in FIG. 4B, the first film 41a and the second film 41b forming the storage space S between the first film 41a and the second film 41b are formed by a single film. There is no seam between the first film 41a and the second film 41b.

[0098] The second container 40 shown in Fig. 4C is also called a pillow type. Both ends of a sheet of film 41 are joined together as a seal portion 49 to form a cylindrical film, and both ends of the cylindrical film are further joined as a seal portion 49 to obtain the second container 40. In the example shown in Fig. 4C, the first film 41a and the second film 41b that forms the storage space S between the first film 41a and the second film 41b are made of a single film material. There is no seam between the first film 41a and the second film 41b.

[0099] As shown in Fig. 4D, the second container 40 may be a gusset bag. In the example shown in Fig. 4D, the second container 40 includes a first film (first main film) 41a, a second film (second main film) 41b, a first gusset film 41c and a second gusset film 41d. The gusset bag can form a rectangular bottom surface. Therefore, the posture of the first container 30 in the second container 40 is stable.

[0100] As shown in Fig. 4E, the second container 40 may be a standing pouch. The second container 40 shown in Fig. 4E includes a first film 41a, a second film 41b, and a bottom film 41e. The standing pouch includes a bottom surface formed by the bottom film 41e. Therefore, the posture of the first container 30 in the second container 40 is stable.

[0101] The film constituting the second container 40 may be transparent. The first container 30 in the storage space S can be observed through the transparent second container 40.

[0102] The second container 40 does not have to be a film container made of a film. As shown in FIG. 4F, the second container 40 may include a container body 42 and a lid 44. The container body 42 includes a storage section 42a and a flange section 42b. The storage section 42a may form a rectangular storage space S. The first container 30 is stored in this storage space S. The storage section 42a may have a rectangular parallelepiped outer shape with one side open. The flange section 42b is provided on the periphery of the opening of the storage section 42a. The lid 44 is flat. The periphery of the lid 44 can be airtightly joined to the flange section 42b of the container body 42. The container body 42 and the lid 44 may be formed of a resin plate having oxygen barrier properties. The lid 44 and the container body 42 may be transparent. The thickness of the resin plate having oxygen barrier properties may be 0.05 mm or more and 2 mm or less, or 0.1 mm or more and 1.5 mm or less.

[0103] The second container 40 shown in FIG. 4F can maintain a negative internal pressure under atmospheric pressure. The second container 40 can contain a gas while maintaining the gas at a negative pressure under atmospheric pressure. The second container 40 may be capable of containing a gas while maintaining the gas at a positive pressure under atmospheric pressure. In these examples, the second container 40 may have sufficient rigidity to maintain its shape. However, the second container 40 may deform somewhat under atmospheric pressure when maintaining a negative or positive internal pressure. An example of the second container 40 capable of maintaining a negative or positive internal pressure is a can made of metal.

[0104] The oxygen-permeable portion of the first container 30 may be at least partially separated from the second container 40 having oxygen barrier properties. According to this example, it is possible to promote the transfer of oxygen from the inside of the first container 30 to the inside of the second container 40. In the illustrated example (for example, the example shown in FIG. 4D ), a gap G is formed between the stopper 34 of the first container 30 housed in the second container 40 and the second container 40.

[0105] The liquid-filled combination container 10L is provided with an oxygen reactant 20 that reacts with oxygen in the second container 40. In this embodiment, the liquid-filled combination container 10L is provided with at least one oxygen reactant 20 that reacts with oxygen in the second container 40. The liquid-filled combination container 10L is provided with at least one oxygen absorbent 21 that absorbs oxygen in the second container 40 as the oxygen reactant 20. The liquid-filled combination container 10L may be provided with an oxygen detector 28 that detects the oxygen state in the second container 40 as the oxygen reactant 20. The liquid-filled combination container 10L may be provided with multiple oxygen reactants 20. In the example shown in FIG. 1A, the liquid-filled combination container 10L is provided with two oxygen reactants 20. In the example shown in FIG. 1A, the liquid-filled combination container 10L is provided with an oxygen absorbent 21 as the first oxygen reactant 20. The liquid-filled combination container 10L is provided with an oxygen detector 28 as the second oxygen reactant 20.

[0106] The oxygen reactant 20 may be fixed to at least one of the outer surface 30b of the first container 30 and the inner surface of the second container 40. In the example shown in FIG. 1A, two oxygen reactants 20 are fixed to the inner surface of the second container 40. When the oxygen reactant 20 is fixed to at least one of the outer surface 30b of the first container 30 and the inner surface of the second container 40, the method of fixing the oxygen reactant 20 is not particularly limited. The oxygen reactant 20 may be fixed to at least one of the outer surface 30b of the first container 30 and the inner surface of the second container 40 by bonding with an adhesive or the like. Although not shown, the oxygen reactant 20 does not have to be fixed to at least one of the outer surface 30b of the first container 30 and the inner surface of the second container 40.

[0107] The oxygen absorbent 21 is not particularly limited as long as it contains a composition capable of absorbing oxygen. As the oxygen absorbent 21, an iron-based oxygen absorber or a non-iron-based oxygen absorber can be used. The oxygen absorbent 21 contains an oxygen absorber composition containing, as a main agent for oxygen absorption reaction, for example, a metal powder such as iron powder, a reducing inorganic substance such as an iron compound, a reducing organic substance such as polyhydric phenols, polyhydric alcohols, ascorbic acid or a salt thereof, or a metal complex. The oxygen absorbent 21 contains, for example, iron oxide. The oxygen absorbent 21 is, for example, an oxygen absorber available from Mitsubishi Gas Chemical Co., Ltd. under the trade name "AGELESS". The above-mentioned composition is contained in the oxygen absorbent 21, for example, as the oxygen absorbent body 22 shown in FIG. 5.

[0108] In the example shown in FIG. 1A, the liquid-containing combination container 10L includes an oxygen absorbent 21 housed in the second container 40 together with the liquid-containing first container 30L. The oxygen absorbent 21 may include an oxygen absorbent body 22. In the example shown in FIG. 5, the oxygen absorbent 21 includes an oxygen permeable packaging body 22a and an oxygen absorbent body 22 housed in the packaging body 22a. As the oxygen absorbent 21 containing the oxygen absorbent body 22, the iron-based moisture-dependent FX type, the iron-based self-reacting S type, the SPE type, the ZP type, the ZI-PT type, the ZJ-PK type, the E type, the organic self-reacting GLS type, the GL-M type, the GE type, and the like, available from Mitsubishi Gas Chemical Company, Inc., may be used. As the oxygen absorbent 21 containing the oxygen absorbent body 22, the pharmaceutical-use ZH type, Z-PK, Z-PR, Z-PKR, ZM type, and the like, available from Mitsubishi Gas Chemical Company, Inc., may be used.

[0109] The oxygen absorbent 21 may be included in the oxygen absorbing film 23. FIG. 6 shows an example of a laminate 46 including the oxygen absorbing film 23. The laminate 46 including the oxygen absorbing film 23 may constitute at least a part of the second container 40. For example, the laminate 46 including the oxygen absorbing film 23 may constitute the films 41a to 41e of the second container 40 shown in FIG. 1A, FIG. 1B, and FIG. 4A to FIG. 4E. The laminate 46 shown in FIG. 6 includes a first layer 46a, a second layer 46b, and a third layer 46c. The first layer 46a may be the outermost layer made of polyethylene terephthalate, nylon, or the like. The second layer 46b may be an oxygen barrier layer made of aluminum foil, an inorganic vapor deposition film, a metal vapor deposition film, or the like. The third layer 46c may be the innermost layer forming a heat seal layer. The illustrated third layer 46c includes a base material made of a thermoplastic resin and an oxygen absorbent 21 dispersed in the base material. As in the example shown in FIG. 6, the second container 40 may include an oxygen absorbing film 23 containing an oxygen absorbent 21 as a part of the laminate 46. The oxygen absorbent 21 is not limited to being included in the heat seal layer or the innermost layer 46c, and may be included in the adhesive layer or an intermediate layer of the laminate. As another example, the first container 30 may include an oxygen absorbing film 23 containing an oxygen absorbent 21. The oxygen absorbent 21 may be provided separately from the first container 30 or the second container 40 as in the examples shown in FIGS. 1A, 1B, 4D, and 4F, or may be provided as a part of the first container 30 or the second container 40 as shown in FIG. 6.

[0110] By absorbing oxygen, the oxygen concentration in the second container 40 decreases, and oxygen in the first container 30 moves to the second container 40. By using the oxygen absorbent 21, the oxygen concentration in the second container 40 and the oxygen concentration in the first container 30 can be more effectively reduced. The inventors of the present invention have confirmed that by using a sufficient amount of the oxygen absorbent 21, the oxygen concentration in the second container 40 and the oxygen concentration in the first container 30 can be maintained low. For example, the oxygen concentration in the second container 40 and the oxygen concentration in the first container 30 can be maintained at less than 0.3%, 0.1% or less, 0.05% or less, less than 0.03%, or even 0%. Furthermore, by the reduction in the oxygen concentration in the first container 30, the amount of oxygen dissolved in the liquid L contained in the first container 30 also decreases. The inventors of the present invention have confirmed that by using a sufficient amount of the oxygen absorbent 21, the amount of oxygen dissolved in the liquid L can be significantly reduced. For example, the amount of dissolved oxygen in liquid L can be maintained at less than 0.15 mg / L, less than 0.04 mg / L, 0.03 mg / L or less, 0.02 mg / L or less, less than 0.015 mg / L, and more preferably 0 mg / L.

[0111] The amount of oxygen absorbent 21 is set to an amount capable of absorbing the total amount of oxygen present in first container 30 and second container 40 .

[0112] The oxygen detector 28 may display the detected oxygen state. The oxygen detector 28 may detect the oxygen concentration. The oxygen detector 28 may display the detected oxygen concentration value. The oxygen detector 28 may display the detected oxygen concentration value by color.

[0113] The oxygen detector 28 may contain a variable organic dye that reversibly changes color due to oxidation and reduction. For example, the oxygen reducer may contain an organic dye such as a thiazine dye, an azine dye, or an oxazine dye, and a reducing agent, and may be in a solid form. The oxygen reducer may also contain an oxygen indicator ink composition. The oxygen indicator ink composition may contain a resin solution, a thiazine dye, etc., reducing sugars, and an alkaline substance. The thiazine dye, etc., reducing sugars, and alkaline substances may be dissolved or dispersed in the resin solution. The substance contained in the oxygen detector 28 may reversibly change due to oxidation and reduction. By using the oxygen detector 28 containing a reversible substance, the oxygen detector 28 contained in the container changes its display color as the oxygen in the container is deoxidized before deoxidation is completed, and the amount of oxygen in the container can be observed from outside the transparent container to grasp the state related to oxygen in the container. Furthermore, the oxygen detector 28 housed in the container can change its display color to indicate an increase in oxygen concentration after deoxidation is complete, for example, when a pinhole or the like is formed in the container during distribution and oxygen has flowed into the container. As an example, the oxygen detector 28 includes a tablet. As an example, the oxygen detector 28 turns pink if the surrounding oxygen concentration is sufficiently low, and turns blue if the surrounding oxygen concentration is high.

[0114] More specifically, as a commercially available tablet-type oxygen detector, for example, an oxygen detector 28 available from Mitsubishi Gas Chemical Co., Ltd. under the product name "Ageless Eye" may be used. As an oxygen detector coated with an ink composition having an oxygen detection function, for example, an oxygen detector 28 available from Mitsubishi Gas Chemical Co., Ltd. under the product name "Paper Eye" may be used. "Ageless Eye" and "Paper Eye" are functional products that can easily indicate an oxygen-free state in which the oxygen concentration in a transparent container is less than 0.1% by volume through a color change. As the oxygen detector 28, a material that can be used together with an oxygen scavenger to maintain the freshness of food and the quality of medical drugs may be used. For example, as the oxygen detector 28, a material that can be used together with an oxygen scavenger to maintain the freshness of food and the quality of medical drugs may be used together with an oxygen scavenger to maintain the freshness of food and the quality of medical drugs.

[0115] As shown in FIG. 1A, the oxygen detector 28 may have a display unit 28a that can be observed from the outside of the transparent second container 40. In the example shown in FIG. 1A, the oxygen detector 28 is accommodated in the second container 40, similar to the oxygen absorber 21. The oxygen detector 28 may be joined to the inner surface of the second container 40 or the outer surface of the first container 30 via welding or a joining material. The oxygen detector 28 may be arranged so that the display unit 28a is not obscured by the oxygen absorber 21. In addition, when a label is attached to the first container 30, it is preferable that the oxygen absorber 21 and the oxygen detector 28 are arranged so as not to cover the label.

[0116] Furthermore, the oxygen detector 28 may detect the oxygen state in the first container 30. This oxygen detector 28 may be housed in the first container 30. The oxygen detector 28 may display the detected oxygen state in the first container 30. The oxygen detector 28 may detect the oxygen concentration in the first container 30. The oxygen detector 28 may display the detected oxygen concentration value in the first container 30. The oxygen detector 28 may display the detected oxygen concentration value in the first container 30 by using a color.

[0117] The liquid-containing combination container 10L includes a water-donating agent 27 that releases water into the interior of the second container 40. The water-donating agent 27 releases water into a space located outside the first container 30 and inside the second container 40. In the example shown in FIG. 1A, the water-donating agent 27 is located outside the first container 30 and inside the second container 40. Although not shown, the water-donating agent 27 may constitute a part of the second container 40. Although not shown, the water-donating agent 27 may constitute a part of the first container 30.

[0118] The water-donating agent 27 is not particularly limited as long as it can release water to maintain the humidity in the second container 40 at 80% RH or more in a state in which the liquid L is contained in the first container 30 and the first container 30 is contained in the second container 40 as shown in FIG. 1A. The water-donating agent 27 may be a humidity-controlling agent having a humidity control function. In other words, the water-donating agent 27 may have a function of absorbing water when the surrounding humidity is high. Such a humidity-controlling agent can also be used as the water-donating agent 27 as long as it can release water when the surrounding humidity is less than 80% RH. The water-donating agent 27 includes, for example, diatomaceous earth. The water-donating agent 27 may include at least one of silica, activated carbon, zeolite, hyaluronic acid, polyacrylate, nonwoven fabric, and a humidity-controlling agent. When the water-donating agent 27 includes a humidity-controlling agent, the humidity-controlling agent may be in the form of a gel, a film, or a sheet.

[0119] In the example shown in FIG. 1A, the water donating agent 27 is not incorporated inside the oxygen reactant 20. Although not shown, the water donating agent 27 may be incorporated inside the oxygen reactant 20. The water donating agent 27 may be incorporated inside the oxygen absorbent 21. In this case, in the oxygen absorbent 21 including the packaging body 22a and the oxygen absorbent body 22 shown in FIG. 5, the water donating agent 27 may be accommodated inside the packaging body 22a together with the oxygen absorbent body 22. In this case, the water donating agent 27 may promote oxygen absorption by the oxygen absorbent 21. In particular, when the liquid L contains a non-aqueous solvent such as alcohol or oil, the water donating agent 27 may promote oxygen absorption by the oxygen absorbent 21.

[0120] As the water donor 27 that is not incorporated inside the oxygen reactant 20, silica, activated carbon, zeolite, hyaluronic acid, polyacrylate, nonwoven fabric, humidity control agent, etc. may be used. As the water donor 27 that is incorporated inside the oxygen reactant 20, diatomaceous earth, silica, activated carbon, zeolite, nonwoven fabric, etc. may be used.

[0121] A method for manufacturing the combination liquid container 10L will now be described. By manufacturing the combination liquid container 10L, the first liquid container 30L having an adjusted oxygen concentration is obtained.

[0122] Next, a method for manufacturing the liquid-containing combination container 10L shown in FIGS. 1A and 1B will be described with reference to FIGS. 7A to 7C.

[0123] First, as shown in FIG. 7A, a liquid-containing first container 30L, an oxygen absorbent 21, an oxygen detector 28, a water donor 27, and a second container 40 are prepared. The second container 40 is not yet closed. In the example shown in FIG. 7A, the first film 41a and the second film 41b are joined at the first seal portion 49a, the first side seal portion 49b, and the second side seal portion 49c. This three-sided seal generally forms a storage space S that accommodates the first container 30, the oxygen absorbent 21, the oxygen detector 28, and the water donor 27. On the other hand, the first film 41a and the second film 41b are not joined at the second seal portion 49d. That is, the second container 40 has an opening 40a that leads to the storage space S. In the second container 40 shown in FIG. 4F, the lid 44 is not joined to the container body 42, and the opening 40a may be formed.

[0124] The liquid-containing first container 30L is manufactured by filling the first container 30 with the liquid L. For example, the liquid L is manufactured using a manufacturing line installed in a sterile environment maintained at a positive pressure. The sterile environment is maintained at a positive pressure in order to prevent the intrusion of foreign matter such as bacteria. As a result, the internal pressure of the obtained liquid-containing first container 30L becomes a positive pressure, similar to the manufacturing environment.

[0125] The partial volume of the first container 30 (volume of the head space HS) obtained by subtracting the volume of the liquid L from the volume of the first container 30 may be 50 mL or less, 30 mL, 10 mL, or 5 mL or less. By adjusting the partial volume of the first container 30 in this manner, when the second container 40 housing the first container 30 is closed in a step described below, the time required for oxygen permeation through the first container 30 to reach equilibrium after the second container 40 is closed can be shortened.

[0126] The volume of the liquid L contained in the first container 30 may be 20 mL or less, or 10 mL or less. The mass of the liquid L contained in the first container 30 may be 20 g or less, 10 g or less, 5 g or less, 3 g or less, or 1 g or less. The mass of the liquid L contained in the first container 30 may be 1 g. The mass of the liquid L contained in the first container 30 may be greater than 1 g. By adjusting the volume of the liquid L in this way, the time required for oxygen permeation through the first container 30 to reach equilibrium after the second container 40 containing the first container 30 is closed can be shortened.

[0127] An upper and lower limit may be set for the ratio (%) of the partial volume (volume of the head space HS) (mL) of the first container 30 obtained by subtracting the volume of the liquid L from the volume of the first container 30 to the partial volume (mL) of the second container 40 obtained by subtracting the volume occupied by the first container 30 from the volume of the second container 40. This ratio may be 90% or less, 50% or less, or 20% or less. By setting such an upper limit, the oxygen concentration in the first container 30 can be sufficiently and quickly reduced. In addition, the storage space for the first container 30 can be secured in the second container 40, and the first container 30 can be easily stored in the second container 40. Furthermore, the time until the permeation of oxygen through the first container 30 reaches equilibrium after the second container 40 containing the first container 30 is closed can be shortened. This makes it possible to suppress decomposition of the liquid L by oxygen. This ratio may be 5% or more, or 10% or more. By setting the lower limit in this manner, the second container 40 does not become too large relative to the first container 30, and the handling properties of the liquid-containing combination container 10L can be improved.

[0128] 7B, the first container 30 is accommodated in the accommodation space S of the second container 40. In the illustrated example, the first container 30 is accommodated in the accommodation space S of the second container 40 such that the container body 32 of the first container 30 faces the first seal portion 49a. The bottom portion 32a of the container body 32 faces the first seal portion 49a in the first direction D1.

[0129] Next, as shown in FIG. 7C, the oxygen absorbent 21, the oxygen detector 28, and the water donor 27 are accommodated in the accommodation space S of the second container 40. In the example shown in FIG. 7C, the oxygen absorbent 21 is in a pouch shape. The oxygen absorbent 21 may be in a sheet shape. The oxygen absorbent 21 may have a bag and a portion that absorbs oxygen accommodated in the bag. The oxygen absorbent 21 is accommodated in the accommodation space S of the second container 40 so that one side edge of the sheet-shaped oxygen absorbent 21 faces the stopper 34 of the first container 30. In the example shown in FIG. 7C, the oxygen detector 28 is in a pouch shape. The oxygen detector 28 may be in a sheet shape. The oxygen detector 28 may have a bag and a portion that detects oxygen accommodated in the bag. The sheet-shaped oxygen detector 28 is overlapped with the oxygen absorbent 21 in the third direction D3. The amount of the oxygen absorbent 21 is set to an amount capable of absorbing the total amount of oxygen present in the first container 30 and the second container 40. The water donating agent 27 is in a sheet form. The sheet-like water donating agent 27 is overlapped with the oxygen absorbent 21 in the third direction D3.

[0130] Before the step of closing the second container 40 described later, the inside of the second container 40 may be replaced with an inert gas. By replacing with an inert gas, the oxygen concentration (%) in the second container 40 can be sufficiently reduced below atmospheric pressure. This causes oxygen to move from the first container 30 to the second container 40, and the amount of oxygen in the first container 30 can be rapidly reduced. By rapidly reducing the amount of oxygen in the first container 30, decomposition of the liquid L by oxygen can be more effectively suppressed. The inert gas is a stable gas with low reactivity. Examples of the inert gas include rare gases such as nitrogen, helium, neon, and argon.

[0131] The replacement with an inert gas can be achieved, for example, by blowing an inert gas into the second container 40, or by closing the second container 40 in a chamber whose atmosphere has been replaced with an inert gas. By doing so, the oxygen concentration in the second container 40 can be reduced to 0.5% or more and 1.0% or less. The replacement with an inert gas in the second container 40 can be smoothly performed because the second container 40 does not directly contain a liquid.

[0132] Thereafter, the first film 41a and the second film 41b are joined at the second seal portion 49d to close the second container 40. The first film 41a and the second film 41b may be joined using a joining material such as an adhesive or a bonding material, or may be welded by heat sealing or ultrasonic bonding. The second container 40 is made airtight. This provides the liquid-containing combination container 10L. Prior to closing the second container 40, the storage space S of the second container 40 may be replaced with an inert gas. The second container 40 may be closed under an inert gas atmosphere. The second seal portion 49d may be formed in a linear shape, unlike the first seal portion 49a. The second seal portion 49d may be joined in a non-peeling manner, unlike the first seal portion 49a. Therefore, even when the first container 30, the oxygen absorber 21, the oxygen detector 28, and the water donor 27 are housed therein, the first film 41a and the second film 41b can be easily and stably joined at the second seal portion 49d.

[0133] In the step of closing the second container 40 containing the first container 30L containing liquid, a volume of gas smaller than the volume obtained by subtracting the volume of the first container 30L containing liquid from the maximum volume that the second container 40 can have may be enclosed. As an example, in the step of closing the second container 40 containing the first container 30L containing liquid, the second container 40 is closed after discharging the gas from the inside of the second container 40. This allows the second container 40 to be closed in a state in which a volume of gas smaller than the volume obtained by subtracting the volume of the first container 30L containing liquid from the maximum volume that the second container 40 can have is enclosed. In this case, it is preferable to close the second container 40 after discharging a volume of gas of 5% or more of the maximum volume that the second container 40 can have from the inside of the second container 40. It is more preferable to discharge a volume of gas of 10% or more of the maximum volume that the second container 40 can have from the inside of the second container 40, and even more preferable to discharge a volume of gas of 20% or more.

[0134] By sealing in a gas of a volume smaller than the maximum volume that the second container 40 can have minus the volume of the liquid-containing first container 30L, the following effects can be obtained: When the oxygen concentration in the head space HS of the first container 30 is reduced by the action of the liquid-containing combination container 10L, and the amount of oxygen dissolved in the liquid L is reduced, the rate at which the oxygen concentration in the head space HS and the amount of oxygen dissolved in the liquid L decrease can be made faster.

[0135] The steps up to closing the second container 40 may be performed in a sterile environment. That is, the liquid-containing first container 30L manufactured in a sterile environment, and the second container 40 and oxygen reactant 20 that have been sterilized or manufactured in a sterile environment are brought into a sterile environment, such as a sterile chamber. In a sterile environment, the second container 40 containing the liquid-containing first container 30L is closed. The inside of the second container 40 containing the liquid-containing first container 30L is also in a sterile state. That is, the liquid-containing first container 30L can be stored in the second container 40 in a sterile state.

[0136] As a result, the liquid-containing combination container 10L shown in FIG. 1A and FIG. 1B is obtained. In the obtained liquid-containing combination container 10L, the liquid-containing first container 30L is stored in the second container 40. The second container 40 has oxygen barrier properties. Therefore, the oxygen in the environment in which the second container 40 is placed is prevented from moving into the second container 40. The oxygen absorbent 21 absorbs oxygen in the second container 40. Therefore, the oxygen concentration (%) in the second container 40 outside the first container 30 is reduced by the oxygen absorption of the oxygen absorbent 21, and becomes lower than the oxygen concentration (%) in the first container 30. The first container 30 has oxygen permeability. Therefore, the oxygen in the first container 30 permeates the first container 30 and moves into the second container 40. More specifically, the oxygen in the first container 30 permeates the permeation part 35 of the first container 30 and moves into the second container 40. As oxygen moves from the first container 30 to the second container 40, the oxygen concentration in the first container 30 decreases. In this manner, by storing the liquid-containing first container 30L in the second container 40, the amount of oxygen in the first container 30 contained in the second container 40 can be adjusted. In a final equilibrium state in which the permeation of oxygen through the first container 30 is balanced, the oxygen concentration in the first container 30 can match the oxygen concentration in the second container 40.

[0137] In addition, when the oxygen concentration in the first container 30 decreases, the oxygen partial pressure in the first container 30 decreases. When the oxygen partial pressure in the first container 30 decreases, the saturation solubility (mg / L) of oxygen in the liquid L in the first container 30 also decreases. As a result, the amount of oxygen dissolved in the liquid L (mg / L) can be reduced.

[0138] The adjustment of the amount of oxygen in the first container 30 in the second container 40 may be performed until the permeation of oxygen through the first container 30 reaches equilibrium. The adjustment of the amount of oxygen in the first container 30 in the second container 40 may be performed until the oxygen concentration (%) in the first container 30 falls to a predetermined value. The adjustment of the amount of oxygen in the first container 30 in the second container 40 may be performed until the amount of oxygen dissolved (mg / L) in the liquid L in the first container 30 falls to a predetermined value. The adjustment of the amount of oxygen in the first container 30 in the second container 40 may be performed until the liquid L in the liquid-containing combination container 10L is used. In addition, while the amount of oxygen in the first container 30 is being adjusted in the second container 40, the liquid-containing combination container 10L may be circulated.

[0139] Since the permeable portion 35 of the first container 30 is at least partially separated from the second container 40, the transfer of oxygen from the first container 30 to the second container 40 can be promoted. In the illustrated example (for example, the example shown in FIG. 4D ), a gap G is formed between the plug 34 forming the permeable portion 35 of the first container 30 housed in the second container 40 and the second container 40. According to this example, it is possible to prevent the second container 40 having oxygen barrier properties from covering the plug 34 having oxygen permeability. This makes it possible to prevent the second container 40 from interfering with the oxygen permeation of the first container 30. Therefore, by providing the gap G, it is possible to promote the reduction of the amount of oxygen in the first container 30.

[0140] The gap G can be secured by making the storage space S of the second container 40 larger than the outer shape of the first container 30. When the second container 40 is made of a flexible material such as a resin film, the shape of the second container 40 can be adjusted to form the gap G between the stopper 34 and the second container 40.

[0141] 1A and 1B, the stopper 34 faces the oxygen reactant 20. Therefore, the oxygen transfer path from the first container 30 to the oxygen reactant 20 through the stopper 34 can be effectively prevented from being unintentionally blocked. For example, the pair of films 41a, 41b are in close contact with each other, so that the oxygen transfer path can be effectively prevented from being blocked. This allows the amount of oxygen in the first container 30 to be steadily and rapidly reduced.

[0142] By the above-mentioned method, it is possible to obtain the first liquid-containing container 30L and the combination liquid-containing container 10L in which the oxygen concentration and the dissolved oxygen amount are adjusted.

[0143] The manufacturing method of the liquid-containing combination container 10L includes a step of closing the second container 40 containing the first container 30, and a step of adjusting the amount of oxygen in the first container 30 contained in the second container 40. At least one oxygen reactant 20 capable of reacting with oxygen in the second container 40 is provided. As an example, an oxygen absorbent 21 that absorbs oxygen in the second container 40 is provided. In the step of adjusting the amount of oxygen, the oxygen in the first container 30 passes through the first container 30, thereby decreasing the oxygen concentration in the first container 30, and the amount of oxygen dissolved in the liquid L can be reduced. According to this embodiment, the oxygen concentration in the first container 30 can be reduced to, for example, less than 0.3%, 0.1% or less, 0.05% or less, less than 0.03%, or even 0%. According to this embodiment, the oxygen concentration in the second container 40 and the oxygen concentration in the first container 30 can be sufficiently reduced. For example, the oxygen concentration in the second container 40 and the oxygen concentration in the first container 30 can be reduced to less than 0.3%, 0.1% or less, 0.05% or less, less than 0.03%, or even 0%. In addition, the amount of dissolved oxygen in the liquid L in the first container 30 can be sufficiently reduced. For example, the amount of dissolved oxygen in the liquid L in the first container 30 can be reduced to less than 0.15 mg / L, 0.04 mg / L or less, preferably 0.03 mg / L or less, more preferably 0.02 mg / L or less, more preferably less than 0.015 mg / L, and even more preferably 0 mg / L. This can reduce the rate of decomposition of the liquid L in the first container 30 due to oxygen, or suppress the decomposition of the liquid L due to oxygen. Since the oxygen absorbent 21 can be disposed outside the first container 30, the oxygen absorbent 21 does not damage the sterility inside the first container 30.

[0144] The functions of the first liquid-containing container 30L and the combination liquid-containing container 10L will be described. The liquid L can be decomposed by oxygen. The solvent of the liquid L as an aqueous solution can be decomposed by oxygen. Solid matter such as particles contained in the liquid L as a suspension can be decomposed by oxygen. Decomposition by oxygen is a more significant problem for the liquid L of food, medicine, etc. Highly sensitive liquids L are easily decomposed by oxygen.

[0145] As described above, the liquid-containing first container 30L and the liquid-containing combination container 10L can sufficiently reduce the oxygen concentration in the first container 30. This can sufficiently reduce the amount of oxygen dissolved in the liquid L contained in the first container 30. The amount of oxygen in the first container 30, i.e., the total amount of oxygen in the head space HS and dissolved oxygen in the liquid L, can be reduced. This can suppress decomposition of the liquid L due to oxygen.

[0146] The oxygen concentration in the space not occupied by the liquid L in the first container 30, i.e., the head space HS shown in FIG. 1A and FIG. 1B, can also be reduced by replacing the head space HS with an inert gas before attaching the stopper 34 to the container body 32. The oxygen concentration in the head space HS can also be reduced by bubbling the liquid L with an inert gas. The oxygen concentration in the head space HS can be reduced to, for example, about 1.5% or less. As an example, the oxygen concentration in the head space HS can be reduced to 0.5% or more and 1% or less. It is considered that the amount of oxygen dissolved in the liquid contained in the container can be reduced by producing a liquid in an atmosphere replaced with an inert gas and storing the liquid in a container having oxygen barrier properties. However, installing the entire line for producing the liquid in an atmosphere replaced with an inert gas requires large-scale renovation of the manufacturing equipment and huge capital investment. In the field of expensive chemicals, etc., in order to ensure stability against temperature, oxygen, moisture, light, etc., the chemicals are freeze-dried and powdered for storage. However, converting liquid chemicals into powder form for storage and then converting the powdered chemicals back into a liquid when used has significant disadvantages in terms of labor, time, and cost.

[0147] In contrast, according to the present embodiment, the first container 30 containing the liquid L can be manufactured using existing equipment and the like without significantly changing the conventional method. Therefore, equipment renovation and capital investment can be avoided. In particular, when applied to liquids such as medicines, it is also useful in that it is possible to omit an application for approval to a public institution regarding changes to the manufacturing equipment and manufacturing process. Furthermore, it is possible to eliminate the trouble of freeze-drying the liquid L or returning the powder to a liquid. Furthermore, there are no special restrictions on the first container 30. Therefore, materials such as glass and resin that are widely used as containers for foods and medicines due to their low elution amount can be adopted. When the container body 32 has a barrier property, the material of the container body 32 is, for example, glass. When the container body 32 does not have a barrier property, the material of the container body 32 is polyethylene, polypropylene, or the like.

[0148] Next, a method of using the liquid-containing combination container 10L will be described.

[0149] When using the liquid L contained in the first container 30 of the liquid-containing combination container 10L, first, the second container 40 is opened. Next, the liquid-containing first container 30L is removed from the opened second container 40. Thereafter, the liquid L can be removed from the liquid-containing first container 30L and used. For the liquid-containing first container 30L shown in FIG. 1C, the first container 30 can be opened by removing the fastener 36 from the container body 32 and further removing the plug 34 from the container body 32. This allows the liquid L in the first container 30 to be used.

[0150] In the liquid-containing combination container 10L shown in FIG. 1A and FIG. 1B, the second container 40 includes a first film 41a and a second film 41b that accommodates the first container 30 between the first film 41a. The first film 41a and the second film 41b are joined in a peelable manner at a seal portion 49. The seal portion 49 includes a first seal portion 49a that faces the first container 30. The first seal portion 49a is bent so as to protrude toward the side away from the first container 30 in a first direction D1 in which the first seal portion 49a and the first container 30 face each other. Therefore, the second container 40 can be easily opened by peeling off the first film 41a and the second film 41b at the first seal portion 49a starting from the bent first seal portion 49a.

[0151] When the second container 40 is opened, the first container 30 is located in the open portion of the second container 40. In particular, the first container 30 can be positioned in the second container 40 by the first seal portion 49a that protrudes toward the side away from the first container 30. Therefore, when the second container 40 is opened, the first container 30 can be stably grasped. This allows the first container 30 to be removed from the second container 40. In other words, when the liquid L contained in the first container 30 is to be used, the first container 30 can be easily removed from the second container 40.

[0152] As shown in FIG. 1A, the sealing portion 49 may include a main sealing portion 49X that divides the space S that accommodates the first container 30, and an auxiliary sealing portion 49Y that joins the first film 41a and the second film 41b at the extension portion 50b. In the illustrated example, the main sealing portion 49X includes the above-mentioned first sealing portion 49a, the first side sealing portion 49b, the second side sealing portion 49c, and the second sealing portion 49d. By providing the auxiliary sealing portion 49Y, it is possible to prevent the first film 41a and the second film 41b from curling at the extension portion 50b. Therefore, by providing the auxiliary sealing portion 49Y, it is possible to make it easier to grip the extension portion 50b of the first film 41a and the second film 41b. This makes it easier to handle the liquid-containing combination container 10L. In addition, the rigidity of the second container 40 is improved at the extension portion 50b, and the first container 30 can be protected by the second container 40.

[0153] In the example shown in FIG. 1A, the auxiliary seal portion 49Y includes a first auxiliary seal portion 49Ya connected to the first side seal portion 49b and a second auxiliary seal portion 49Yb connected to the second side seal portion 49c. The first auxiliary seal portion 49Ya may extend linearly on an extension line of the first side seal portion 49b. The second auxiliary seal portion 49Yb may extend linearly on an extension line of the second side seal portion 49c. According to these examples, it is possible to more effectively prevent the first film 41a and the second film 41b from curling at the extension portion 50b. According to these examples, the rigidity of the second container 40 is more effectively improved at the extension portion 50b.

[0154] The configuration of the auxiliary seal portion 49Y is not limited to the configuration shown in FIG. 1A and the like. As shown in FIG. 1D, the auxiliary seal portion 49Y may be separated from the main seal portion 49X. In the example shown in FIG. 1D, the auxiliary seal portion 49Y includes a first auxiliary seal portion 49Ya located on an extension line of the first side seal portion 49b and a second auxiliary seal portion 49Yb located on an extension line of the second side seal portion 49c. The first auxiliary seal portion 49Ya and the second auxiliary seal portion 49Yb may be linear, may be a broken line, or may be dot-shaped as shown in FIG. 1D. These examples also prevent the first film 41a and the second film 41b from curling at the extension portion 50b. These examples also improve the rigidity of the second container 40 at the extension portion 50b.

[0155] As shown in FIG. 8, the liquid L may be an injection. Examples of the injection include an anticancer drug, an antiviral drug, a vaccine, and an antipsychotic. The liquid L may be taken out from the first container 30 using a syringe 60. The syringe 60 may include a cylinder 62 and a piston 66, similar to the syringe constituting the first container 30 described above. The cylinder 62 may include a cylinder body 63 and a needle 64 protruding from the cylinder body 63. The cylindrical needle 64 allows access to the space in the cylinder body 63 for storing the liquid L. The piston 66 may include a piston body 67 and a gasket 68 held by the piston body 67. The gasket 68 may be made of rubber or the like. The gasket 68 is inserted into the cylinder body 63 to partition a storage space for the liquid L within the cylinder body 63. The liquid L injected into the syringe 60 may be transferred from the syringe 60 to another syringe, container, or the like before being administered to a patient or the like. In this example, it may be administered to the patient from a separate syringe, container, etc.

[0156] The pressure in the first liquid-containing container 30L may be adjusted. As an example, the pressure in the first liquid-containing container 30L may be maintained low or negative. According to this example, it is possible to suppress unintended leakage of the liquid L during storage of the first liquid-containing container 30L, and scattering of the liquid L when the first container 30 is opened. The problem of leakage and scattering is more serious for toxic liquids, such as highly pharmacologically active drugs. In addition, in the example shown in FIG. 8, if the first liquid-containing container 30L is under positive pressure, the liquid L automatically enters the syringe 60. In this case, it becomes difficult to inject the desired amount of liquid L into the syringe 60 with high accuracy.

[0157] On the other hand, liquids L that deteriorate due to post-sterilization treatment carried out after production using, for example, gas, heat, gamma rays, etc., such as anticancer drugs, antiviral drugs, vaccines, antipsychotics, etc., are produced in a sterile environment and sealed in a container. That is, liquids L to which terminal sterilization cannot be applied are produced by an aseptic operation method. This sterile environment is usually maintained at a predetermined positive pressure to suppress the intrusion of bacteria. Therefore, the pressure inside the container becomes a predetermined positive pressure corresponding to the sterile environment, and it is difficult to adjust the internal pressure of the container after the container is closed.

[0158] The liquid-containing combination container 10L can address such problems. As described above, the liquid-containing first container 30L is stored in the second container 40. During this storage, oxygen in the first container 30 passes through the first container 30 and moves into the second container 40. This causes the pressure in the first container 30 to decrease. In other words, the pressure in the first container 30 containing the liquid L can be adjusted after the first container 30 is closed and the liquid L is sealed in.

[0159] As described above, according to the liquid-containing combination container 10L of the present embodiment, oxygen in the first container 30 can be moved to the outside of the first container 30 by permeating the permeation section 35. This reduces the oxygen concentration in the first container 30, and the amount of oxygen dissolved in the liquid L (mg / L) can be reduced. On the other hand, in the liquid-containing combination container 10L of the present embodiment, since the first container 30 has the permeation section 35, water in the first container 30 can permeate the first container 30 in the form of water vapor and leak out of the first container 30. For this reason, it is required to reduce the amount of water contained in the liquid L while reducing the amount of oxygen dissolved in the liquid L (mg / L) in the first container 30.

[0160] The inventors conducted extensive research in light of the above problems and discovered that if the humidity inside the second container 40 is maintained at 80% RH or higher, the amount of water lost in the liquid L can be reduced, and thus completed the liquid-filled combination container 10L of the present embodiment.

[0161] In the liquid-containing combination container 10L of this embodiment, the humidity in the second container 40 (humidity in the space outside the first container 30 and inside the second container 40) is maintained at 80% RH or more. More specifically, the liquid-containing combination container 10L of this embodiment is configured so that when the humidity in the second container 40 is 80% RH or more, the humidity in the second container 40 is maintained at 80% RH or more. In addition, the liquid-containing combination container 10L of this embodiment is configured so that when the humidity in the second container 40 is less than 80% RH, the humidity in the second container 40 increases until it becomes 80% RH or more. In other words, the liquid-containing combination container 10L of this embodiment is configured so that when the amount of water vapor inside the second container 40 reaches equilibrium, the humidity in the second container 40 becomes 80% RH or more.

[0162] The following will explain the possible reasons why the amount of water lost in the liquid L can be reduced by maintaining the humidity in the second container 40 at 80% RH or higher. The amount of water lost in the liquid L in a given time can be reduced by reducing the rate at which the water in the first container 30 leaks out of the first container 30 through the first container 30. The rate at which the water in the first container 30 leaks out of the first container 30 (into the second container 40) through the first container 30 is determined according to the difference between the humidity in the first container 30 and the humidity in the second container 40. In particular, when the transmission section 35 is in contact with the head space HS as shown in FIG. 1A, the rate at which the water in the first container 30 leaks into the second container 40 is determined according to the difference between the humidity in the head space HS of the first container 30 and the humidity in the second container 40. The humidity in the second container 40 is lower than the humidity in the first container 30, so that the water in the first container 30 leaks into the second container 40 through the first container 30. The smaller the difference between the humidity in the first container 30 and the humidity in the second container 40, the slower the rate at which the water in the first container 30 permeates the first container 30 and leaks into the second container 40.

[0163] By maintaining the humidity in the second container 40 at 80% RH or more, the difference obtained by subtracting the humidity in the second container 40 from the humidity in the first container 30 is reduced, and the rate at which the water in the first container 30 leaks into the second container 40 can be reduced. Furthermore, in this embodiment, the water vapor transmission rate of the first container 30 is 2.75 (mg / day) or less in an atmosphere with a temperature of 20° C. and a humidity of 85% RH, so that the rate at which the water in the first container 30 leaks into the second container 40 is also kept low. By maintaining the water vapor transmission rate of the first container 30 at 2.75 (mg / day) or less in an atmosphere with a temperature of 20° C. and a humidity of 85% RH and maintaining the humidity in the second container 40 at 85% RH or more, the rate at which the water in the first container 30 leaks into the second container 40 can be sufficiently reduced. This makes it possible to reduce the amount of water lost in the liquid L in a given time.

[0164] In particular, in the first container 30 that contains the liquid L and is made airtight as described above, if a sufficient amount of time has passed since the second container 40 was closed, the humidity in the head space HS is usually 80% RH or more and 100% RH or less. In consideration of this, by maintaining the humidity in the second container 40 at 80% RH or more, the rate at which water in the first container 30 leaks into the second container 40 can be sufficiently reduced.

[0165] From the viewpoint of reducing the rate at which the water in the first container 30 leaks into the second container 40, the humidity in the second container 40 may be maintained at 85% RH or higher, or may be maintained at 90% RH or higher. From the viewpoint of suppressing the leakage of the water in the first container 30 into the second container 40, the humidity in the second container 40 may be maintained to be equal to or higher than the humidity in the first container 30.

[0166] As an example, by providing the liquid-containing combination container 10L with the water-donating agent 27, the humidity inside the second container 40 can be maintained at 80% RH or higher due to the following action of the water-donating agent 27. The water-donating agent 27 releases water into the inside of the second container 40. This increases the humidity inside the second container 40 and allows it to be maintained at 80% RH or higher.

[0167] As an example, the water-donating agent 27 releases water into the second container 40 in an atmosphere with a temperature of 20° C. and a humidity of 80% RH. Such a water-donating agent 27 can act to maintain the humidity in the second container 40 at 80% RH or higher. It is more preferable that the water-donating agent 27 releases water into the second container 40 in any atmosphere with a temperature of 2° C. or higher and 30° C. or lower and a humidity of 80% RH or lower. This allows the water-donating agent 27 to release water into the second container 40 when the humidity is 80% RH or lower at least when the temperature is 2° C. or higher and 30° C. or lower. Such a water-donating agent 27 can act to maintain the humidity in the second container 40 at 80% RH or higher.

[0168] Usually, when the water-donating agent 27 releases water at a first humidity (%RH), it also releases water at a second humidity (%RH) lower than the first humidity (%RH). Therefore, the water-donating agent 27 that releases water into the second container 40 in an atmosphere with a temperature of 20°C and a humidity of 80%RH is considered to release water into the second container 40 in any atmosphere with a temperature of 20°C and a humidity of 80%RH or less. Therefore, such a water-donating agent 27 can act to maintain the humidity in the second container 40 at 80%RH or more. It is more preferable that the water-donating agent 27 releases water into the second container 40 in any atmosphere with a temperature of 2°C or more and a humidity of 80%RH or less. Such a water-donating agent 27 is considered to release water into the second container 40 in any atmosphere with a temperature of 2°C or more and a humidity of 30°C or less and a humidity of 80%RH or less. Therefore, such a water-donating agent 27 can act to maintain the humidity in the second container 40 at 80%RH or more.

[0169] The action of the water donor 27 will be described in more detail. As the movement of water in the liquid-containing combination container 10L, the movement of water in the first container 30 permeating the first container 30 and leaking out of the first container 30 has been described above. However, as the movement of water in the liquid-containing combination container 10L, the movement of water permeating the second container 40 from the second container 40 to the outside of the second container 40 is also assumed. As the movement of water in the liquid-containing combination container 10L, the movement of water in the second container 40 being absorbed by the second container 40 is also assumed. FIG. 9 is a diagram showing the movement of water in the liquid-containing combination container 10L. In FIG. 9, the arrows marked with the symbol Aa indicate the movement of water permeating the second container 40 from the inside of the second container 40 to the outside of the second container 40. In this movement, water in the form of water vapor in particular permeates the second container 40 from the inside of the second container 40 to the outside of the second container 40. In FIG. 9, the arrows with the symbol Ab indicate the movement of water in the second container 40, which is absorbed into the second container 40. In this movement, particularly, water present in the second container 40 in the form of water vapor is absorbed into the second container 40, and is removed from the atmosphere in the second container 40 (the space outside the first container 30 and inside the second container 40). In FIG. 9, the arrows with the symbol B indicate the movement of water in the first container 30, which permeates the first container 30 and leaks out of the first container 30. In this movement, particularly, water in the form of water vapor permeates the first container 30 from inside the first container 30 and leaks out of the first container 30 (into the second container 40). In FIG. 9, the arrows with the symbol C indicate the movement of water released as water vapor from the water-donating agent 27 into the second container 40. The water movements indicated by the arrows labeled Aa, Ab, B, and C are referred to as movement Aa, movement Ab, movement B, and movement C, respectively.

[0170] When the water movements Aa and Ab occur, the humidity decreases in the second container 40. According to the water-donating agent 27, even when the water movements Aa and Ab are taken into consideration, the humidity in the second container 40 can be maintained at 80% RH or more.

[0171] The water-donating agent 27 preferably has the following properties. The atmosphere inside the second container 40 is set to a temperature of 20° C. and a humidity of 80% RH. The water-donating agent 27 is placed in a position where it can release water into the second container 40. The liquid-containing first container 30L is not contained in the second container 40. In this way, the atmosphere inside the second container 40 is set to a temperature of 20° C. and a humidity of 80% RH, and the second container 40 is left for six hours. At this time, it is preferable that the water-donating agent 27 increases the humidity inside the second container 40 by 1% RH or more. In other words, it is preferable that the water-donating agent 27 increases the humidity inside the second container 40 to a value of 81% RH or more during six hours. With such a water-donating agent 27, the humidity inside the second container 40 can be more stably maintained at 80% RH or more even when the water movements Aa and Ab are taken into consideration. With the water-donating agent 27, the humidity inside the second container 40 can also be maintained at a value greater than 80% RH.

[0172] According to the liquid-containing combination container 10L of the present embodiment, the humidity in the second container 40 can be more stably maintained at 80% RH or more by limiting at least one of the amount of water moving Aa per unit time and the amount of water moving Ab per unit time. The humidity in the second container 40 may be maintained at a value greater than 80% RH by limiting at least one of the amount of water moving Aa and the amount of water moving Ab.

[0173] As an example, a case where the amount of water moving Ab is limited will be described. When the humidity inside the second container 40 is 80% RH and the temperature is 20° C., the mass of water vapor absorbed inside the second container 40 per day is defined as Ab1 (mg / day). From the viewpoint of more stably maintaining the humidity inside the second container 40 at 80% RH or more and maintaining the humidity inside the second container 40 at a larger value, it is preferable that Ab1 (mg / day) is 20 (mg / day) or less.

[0174] The humidity in the second container 40 can be maintained at 80% RH or more by limiting the total amount of the amount of water that moves Aa and the amount of water that moves Ab. As an example, consider a case where the inside of the second container 40 is an atmosphere with a temperature of 20° C. and a humidity of 80% RH, and the outside of the second container 40 is an arbitrary atmosphere with a temperature of 20° C. and a humidity of 40% RH or more and 50% RH or less. In this case, the total mass per day of the water vapor that permeates and moves through the second container 40 and the water vapor absorbed by the second container 40 inside the second container 40 is A1 (mg / day). In this case, from the viewpoint of more stably maintaining the humidity in the second container 40 at 80% RH or more and from the viewpoint of maintaining the humidity in the second container 40 at a larger value, it is preferable that A1 (mg / day) is 300 (mg / day) or less. In particular, the humidity in a normal room is about 40% RH or more and 50% RH or less. Therefore, by having A1 (mg / day) be 300 (mg / day) or less, when the humidity outside the second container 40 is approximately the same as the humidity in a normal room, the humidity inside the second container 40 can be more stably maintained at 80% RH or more. By having A1 (mg / day) be 300 (mg / day) or less, the humidity inside the second container 40 can also be maintained at a higher value. A1 (mg / day) may be 150 (mg / day) or less, or may be 50 (mg / day) or less.

[0175] A limit may be set on the amount of water that moves B per unit time. As an example, consider a case where the inside of the first container 30 is an atmosphere with a temperature of 20°C and a humidity of 95% RH, and the outside of the first container 30 is an arbitrary atmosphere with a temperature of 20°C and a humidity of 80% RH or more and 95% RH or less. In this case, the mass of water vapor that permeates and moves through the first container 30 per day is B1 (mg / day). In this case, B1 (mg / day) may be 2.75 (mg / day) or less. If B1 (mg / day) is 2.75 (mg / day) or less, the speed at which the water in the first container 30 leaks into the second container 40 is sufficiently suppressed to a low level. This allows the amount of water contained in the liquid L to be reduced.

[0176] The liquid-containing combination container 10L capable of reducing the amount of water loss contained in the liquid L will be further described from a different perspective than the above. The present inventors have found that in the manufacture of the liquid-containing combination container 10L, the amount of water loss contained in the liquid L is preferably 2 mg or less until 14 days have passed since the second container 40 containing the first container 30 is closed. In particular, in "2.2. Polyethylene or polypropylene aqueous injection containers" of "7.02 Test methods for plastic drug containers" of the Japanese Pharmacopoeia, 18th Edition, a standard is set forth that the water vapor permeability of the container is 0.20% or less when tested according to "1.5.1. Method 1". When the liquid L is a drug and the mass of the liquid L contained in the first container 30 is 1 g, the above standard of the Japanese Pharmacopoeia, 18th Edition, is satisfied by the amount of water loss until 14 days have passed being 2 mg or less. Therefore, by setting the amount of water loss in the liquid-containing combination container 10L to 2 mg after 14 days, even if the liquid L is a medicine and the mass of the liquid L contained in the first container 30 is 1 g, the above-mentioned standard of the 18th revised Japanese Pharmacopoeia can be met. Furthermore, if the above-mentioned standard of the 18th revised Japanese Pharmacopoeia is met when the mass of the liquid L contained in the first container 30 is 1 g in the liquid-containing combination container 10L, it is considered that the above-mentioned standard of the 18th revised Japanese Pharmacopoeia is met even when the mass of the liquid L contained in the first container 30 is greater than 1 g. Therefore, according to the liquid-containing combination container 10L in this embodiment, when the liquid L is a medicine and the mass of the liquid L contained in the first container 30 is 1 g or more, the above-mentioned standard of the 18th revised Japanese Pharmacopoeia can be met. Usually, when a liquid medicine is contained in a container, a medicine with a mass of 1 g or more is contained in the container. It is rare that a medicine with a mass less than 1 g is required to be contained in a container. As described above, the liquid-containing combination container 10L in this embodiment can meet the standards of the 18th revised Japanese Pharmacopoeia as long as it contains medicines in a commonly considered manner of use. Therefore, the liquid-containing combination container 10L in this embodiment is particularly suitable for containing the liquid L, which is a medicine.

[0177] On the other hand, after the second container 40 containing the first container 30 is closed during the manufacture of the liquid-containing combination container 10L, the amount of water present in the form of water vapor inside the second container 40 (the space outside the first container 30 and inside the second container 40) is considered to change as follows. The humidity inside the second container 40 immediately after the second container 40 containing the first container 30 is closed is considered to be approximately the same as the humidity in the environment in which the work of closing the second container 40 is performed. When the work of closing the second container 40 is performed in a normal room, the humidity inside the second container 40 immediately after the second container 40 is closed is, for example, 40% RH or more and 50% RH or less. In contrast, as described above, the humidity inside the first container 30 (in the head space HS of the first container 30 containing the liquid L) is usually 80% RH or more and 100% RH or less. Therefore, immediately after the second container 40 containing the first container 30 is closed, the humidity in the second container 40 is lower than the humidity in the first container 30, and the difference obtained by subtracting the humidity in the second container 40 from the humidity in the first container 30 is relatively large. As a result, immediately after the second container 40 containing the first container 30 is closed, the water in the first container 30 leaks into the second container 40 at a relatively high speed. Immediately after the second container 40 containing the first container 30 is closed, the water in the first container 30 leaks into the second container 40 at a high speed, so that the humidity in the second container 40 rises. Furthermore, when the water-donating agent 27 is contained in the second container 40 together with the first container 30, the humidity in the second container 40 also rises immediately after the second container 40 is closed, because the water-donating agent 27 releases water into the second container 40. As described above, immediately after the second container 40 containing the first container 30 is closed, the amount of water present in the form of water vapor within the second container 40 increases.

[0178] As time passes after the second container 40 is closed, the humidity in the second container 40 increases, and the difference between the humidity in the first container 30 and the humidity in the second container 40 decreases. This reduces the rate at which the water in the first container 30 leaks into the second container 40. This reduces the amount of water in the form of water vapor that moves (movement Aa) from the first container 30 to the second container 40 per unit time. Accordingly, the amount of water vapor that increases in the second container 40 per unit time decreases. As a result, when a sufficient amount of time has passed since the second container 40 was closed, the amount of water vapor that increases in the second container 40 per unit time becomes equal to the amount of water vapor lost from the second container 40 per unit time. That is, the amount of water vapor inside the second container 40 reaches equilibrium.

[0179] Consider a case where transfer Aa, transfer Ab, transfer B, and transfer C are assumed as the transfer of water in the liquid-containing combination container 10L as shown in Fig. 9. In this case, the amount of water vapor increasing in the second container 40 per unit time is the sum of the amount of water undergoing transfer B and the amount of water undergoing transfer C per unit time. The amount of water vapor lost from the second container 40 per unit time is the sum of the amount of water undergoing transfer Aa and the amount of water undergoing transfer Ab per unit time. In this case, the amount of water vapor inside the second container 40 reaches equilibrium when the sum of the amount of water undergoing transfer B and the amount of water undergoing transfer C per unit time becomes equal to the sum of the amount of water undergoing transfer Aa and the amount of water undergoing transfer Ab per unit time.

[0180] From the viewpoint of keeping the amount of water contained in the liquid L small, it is preferable that the time D from when the second container 40 is closed until the amount of water vapor inside the second container 40 reaches equilibrium is short. During the time D, the rate at which water in the first container 30 leaks into the second container 40 is likely to be high compared to after the amount of water vapor inside the second container 40 reaches equilibrium. By shortening the time D during which the rate is likely to be high, the amount of water leaking from the first container 30 until a predetermined time (e.g., 14 days) has elapsed since the second container 40 is closed can be reduced. This keeps the amount of water contained in the liquid L small during the predetermined time. The time D is, for example, shorter than 14 days.

[0181] Time D can be kept short by setting an upper limit on at least one of the amount of water moving Aa and the amount of water moving Ab. By setting an upper limit on at least one of the amount of water moving Aa and the amount of water moving Ab, the amount of water in the form of water vapor lost from the second container 40 is reduced. This can increase the humidity in the second container 40 quickly. Therefore, the amount of water vapor inside the second container 40 reaches equilibrium early, and time D can be kept short.

[0182] Time D can also be kept short by setting a lower limit on the amount of water that moves C. By setting a lower limit on the amount of water that moves C, the amount of water vapor that increases inside the second container 40 increases. This can increase the humidity inside the second container 40 quickly. Therefore, the amount of water vapor inside the second container 40 reaches equilibrium early, and time D is kept short.

[0183] From the viewpoint of keeping the amount of water contained in the liquid L small, it is preferable that the amount of water moving (movement B) from inside the first container 30 to inside the second container 40 in a state in which the amount of water vapor inside the second container 40 has reached equilibrium is small. This makes it possible to keep the amount of water leaking from inside the first container 30 until a predetermined time (e.g., 14 days) has elapsed since the amount of water vapor inside the second container 40 reached equilibrium. This makes it possible to keep the amount of water contained in the liquid L small during the predetermined time.

[0184] In a state where the amount of water vapor inside the second container 40 has reached equilibrium, as described above, the humidity inside the second container 40 is maintained at 80% RH or higher, thereby making it possible to reduce the amount of water that moves from inside the first container 30 to inside the second container 40. Furthermore, the amount of water that moves from inside the first container 30 to inside the second container 40 can also be reduced by making the water vapor transmission rate of the first container 30 2.75 (mg / day) or less in an atmosphere at a temperature of 20° C. and a humidity of 85% RH. This makes it possible to keep the amount of water contained in the liquid L reduced in the specified time period small.

[0185] An upper limit may be set for the amount of water moving from inside the first container 30 to inside the second container 40. As an example, B2 (mg / day), which is the mass per day of water vapor moving from inside to outside the first container 30 through the first container 30 in a state in which the amount of water vapor inside the second container 40 has reached equilibrium, is 0.14 (mg / day) or less. This allows the amount of water leaking from the first container 30 until a predetermined time has elapsed since the amount of water vapor inside the second container 40 has reached equilibrium to be sufficiently small. In particular, consider a case in which the effect of the speed at which water leaks from the first container 30 being greater during the time D than after the amount of water vapor inside the second container 40 has reached equilibrium can be ignored because the time D is sufficiently short. In this case, by setting B2 (mg / day) to 0.14 (mg / day) or less, the amount of water leaking from the first container 30 until a predetermined time has elapsed since the second container 40 is closed can be sufficiently small. In particular, by setting B2 (mg / day) to 0.14 (mg / day) or less, the amount of water leaking from the first container 30 until 14 days have elapsed since the second container 40 was closed can be set to 2 mg or less. This allows the amount of water contained in the liquid L to be reduced to 2 mg or less until 14 days have elapsed since the second container 40 was closed.

[0186] An upper limit may be set for the time D. In the liquid-containing combination container 10L, a state in which the temperature is 20°C, the humidity inside the first container 30 is 100%RH, and the humidity inside the second container 40 and the humidity outside the second container 40 are 40%RH is referred to as an initial state. The time D from this initial state until the amount of water vapor inside the second container 40 reaches equilibrium is referred to as an elapsed time DA. The elapsed time DA (days) may be 3 (days) or less. When the work of closing the second container 40 is performed in a normal room, the humidity inside the second container 40 immediately after the second container 40 is closed is usually 40%RH or more. Furthermore, when the liquid-containing combination container 10L is placed in a normal room, the humidity outside the second container 40 is usually 40%RH or more. Therefore, if the elapsed time DA (days) is 3 (days) or less, the time D when the work of closing the second container 40 is performed in a normal room with a temperature of 20°C is also 3 (days) or less. By setting the time D to 3 (days) or less, the amount of water leaking from the first container 30 until a predetermined time has elapsed since the second container 40 was closed can be made smaller.

[0187] The mass of water vapor that passes through the first container 30 and moves from the inside to the outside of the first container 30 during the elapsed time DA (days) from the above-mentioned initial state is defined as E (mg). The mass of water vapor that passes through the first container 30 and moves from the inside to the outside of the first container 30 per day in a state in which the amount of water vapor inside the second container 40 has reached equilibrium is defined as B2 (mg / day). In this case, the elapsed time DA (days), E (mg), and B2 (mg / day) may satisfy the following formula (1).

number

[0188] The mass of water leaking from the first container 30 until the amount of water vapor inside the second container 40 reaches equilibrium from the initial state is E (mg). The mass of water leaking from the first container 30 until 14 days have passed since the initial state after the amount of water vapor inside the second container 40 reaches equilibrium is B2 (14-DA) (mg). Therefore, by satisfying the above formula (1), the amount of water leaking from the first container 30 until 14 days have passed from the initial state when the temperature is 20°C can be reduced to 2 mg or less. As described above, when the work of closing the second container 40 is performed in a normal room, the humidity inside the second container 40 immediately after closing the second container 40 is usually 40% RH or more. Therefore, by setting the amount of water leaking from first container 30 within 14 days from the initial state to 2 mg or less when the temperature is 20° C., the amount of water leaking from first container 30 within 14 days after second container 40 is closed can be set to 2 mg or less when the second container 40 is closed in a normal room at a temperature of 20° C. This allows the amount of water contained in liquid L to decrease by 2 mg or less until 14 days have passed since second container 40 is closed.

[0189] A description will now be given from a different perspective from the above regarding the characteristics of the liquid-containing combination container 10L that can reduce the amount of water lost from the liquid L. As described above, when the amount of water vapor inside the second container 40 has reached equilibrium, the amount of water lost from the liquid L can be reduced by maintaining the humidity inside the second container 40 at 85% RH or higher.

[0190] Consider an environment in which the humidity inside the second container 40 is 80% RH, the humidity outside the second container 40 is 40% RH, and the temperature is 20°C. In this environment, the total mass per day of the water vapor that passes through the second container 40 and moves from the inside to the outside of the second container 40 and the water vapor absorbed by the second container 40 inside the second container 40 is A3 (mg / day). Consider an environment in which the humidity inside the first container 30 is 100% RH, the humidity outside the first container 30 is 80% RH, and the temperature is 20°C. In this environment, the mass per day of the water vapor that passes through the first container 30 and moves from the inside to the outside of the first container 30 is B3 (mg / day). The mass per day of the water vapor released by the water-donating agent 27 in an atmosphere with a temperature of 20°C and a humidity of 80% RH is C3 (mg / day). In this case, A3 (mg / day), B3 (mg / day), and C3 (mg / day) may satisfy the following formula (2).

number

[0191] When formula (2) is satisfied, the following effects can be obtained. If A3 = B3 + C3, when a 10L combined container with liquid is placed in an environment with a temperature of 20°C and a humidity of 40%RH, when the humidity in the second container 40 reaches 80%RH, the amount of water vapor inside the second container 40 reaches equilibrium. If A3 < B3 + C3, when a 10L combined container with liquid is placed in an environment with a temperature of 20°C and a humidity of 40%RH, after the humidity in the second container 40 exceeds 80%RH, the amount of water vapor inside the second container 40 reaches equilibrium. From the above, when formula (2) is satisfied, when a 10L combined container with liquid is placed in an environment with a temperature of 20°C and a humidity of 40%RH, in a state where the amount of water vapor inside the second container 40 has reached equilibrium, the humidity inside the second container 40 can be maintained at 80%RH or higher. The humidity in a normal room is 40%RH or higher. Therefore, when formula (2) is satisfied, when a 10L combined container with liquid is placed in a normal room with a temperature of 20°C, in a state where the amount of water vapor inside the second container 40 has reached equilibrium, the humidity inside the second container 40 can be maintained at 80%RH or higher. As a result, the reduction amount of the water contained in the liquid L can be reduced.

[0192] C3 (mg / day) may be 0.1 (mg / day) or more. Thereby, when A3 (mg / day) is 0.1 (mg / day) or less, formula (2) is satisfied.

[0193] A3 (mg / day) is obtained by the following method. First, prepare a 10L combined container with liquid to be measured. Next, set the humidity inside the second container 40 of the 10L combined container with liquid (the space outside the first container 30 and inside the second container 40) to 80%RH, the humidity outside the second container 40 to 40%RH, and the temperature to 20°C. Also, set the humidity inside the first container 30 to 100%RH. Next, leave the 10L combined container with liquid for one day. Then, measure how much the total mass of the 10L combined container with liquid has decreased compared to before leaving it. Consider this decrease amount as the mass per day of the water vapor that permeates through the second container 40 described above and moves from the inside to the outside of the second container 40.

[0194] In addition, two second containers 40 are prepared for the liquid-containing combination container 10L to be measured. Next, the humidity inside and outside one of the second containers 40 is set to 80% RH and the temperature is set to 20°C. The humidity inside and outside the other second container 40 is set to 40% RH and the temperature is set to 20°C. Next, the two second containers 40 are left for one day. The difference between the mass of one of the second containers 40 placed at a humidity of 80% RH after being left for one day and the mass of the other second container 40 placed at a humidity of 40% RH after being left for one day is regarded as the mass of water vapor absorbed by the second container 40 inside the second container 40 described above per day.

[0195] A3 (mg / day) is obtained by adding up the mass of water vapor per day that passes through the above-mentioned second container 40 and moves from the inside to the outside of the second container 40 and the mass of water vapor per day that is absorbed by the second container 40 inside the above-mentioned second container 40.

[0196] B3 (mg / day) is obtained by the following method. First, prepare the first container 30L containing liquid of the liquid-containing combination container 10L to be measured. Next, set the humidity outside the first container 30 to 80% RH, the humidity inside the first container 30 to 100% RH, and the temperature to 20°C. Next, leave the first container 30L containing liquid for one day. Then, measure how much the mass of the first container 30L containing liquid has decreased compared to before it was left. The amount of decrease is regarded as the mass per day of water vapor that permeates the first container 30 described above and moves from the inside to the outside of the first container 30, i.e., B3 (mg / day).

[0197] When the water-donating agent 27 is not incorporated inside the oxygen reactant 20, C3 (mg / day) can be obtained by the following method. First, prepare the water-donating agent 27 for the liquid-containing combination container 10L to be measured. Next, place the water-donating agent 27 in an atmosphere with a temperature of 20°C and a humidity of 80% RH. Next, leave the water-donating agent 27 for one day. Then, measure how much the mass of the water-donating agent 27 has decreased compared to before it was left. The amount of decrease is regarded as the mass of water vapor released by the water-donating agent 27 per day in an atmosphere with a temperature of 20°C and a humidity of 80% RH, i.e., C3 (mg / day).

[0198] When the water-donating agent 27 is incorporated inside the oxygen reactant 20, C3 (mg / day) can be obtained by the following method. First, prepare the oxygen reactant 20 with the water-donating agent 27 incorporated inside, which is a liquid-containing combination container 10L to be measured. Next, place the oxygen reactant 20 in an atmosphere with a temperature of 20°C, a humidity of 80% RH, and nitrogen purging. Next, leave the oxygen reactant 20 for one day. Then, measure how much the mass of the oxygen reactant 20 has decreased compared to before it was left. The amount of decrease is regarded as the mass of water vapor released by the water donating agent 27 per day in an atmosphere with a temperature of 20°C and a humidity of 80% RH, i.e., C3 (mg / day).

[0199] The humidity inside a container such as the first container 30 or the second container 40 can be calculated based on the water vapor partial pressure of the water vapor present inside the container. Specifically, the water vapor partial pressure can be calculated by dividing the water vapor partial pressure by the saturated water vapor pressure at the temperature inside the container. The water vapor partial pressure inside the container is measured from the absorbance of the laser light when the laser light passes through the inside of the container. The number of water molecules present on the optical path through which the laser light passes can be calculated from the absorbance of the laser light when the laser light passes through the inside of the container. The optical path through which the laser light passes includes a portion that passes through the inside of the container to be measured and a portion that passes through the outside of the container to be measured. From the number of water molecules present on the portion of the optical path that passes through the inside of the container to be measured, the water vapor partial pressure inside the container to be measured can be measured.

[0200] The device for measuring the partial pressure of water vapor inside a container includes a light source for irradiating a laser beam, a measuring device for measuring the absorbance of the laser beam, and a fixing part for fixing the container to be measured, which is located between the light source and the measuring device. For example, a head space analyzer (Head Space Analyzer FMS1400 manufactured by Lighthouse) is used as the device for measuring the partial pressure of water vapor inside a container. When measuring the partial pressure of water vapor, calibration is performed using a method recommended by the manufacturer of the measuring device to be used. At this time, as the calibration vial to be used for calibration, a plurality of calibration vials with different vial diameters may be prepared. In this case, the vial with the diameter closest to the diameter of the container to be measured should be used. Calibration should be performed in the environment in which the actual measurement is performed.

[0201] In measuring the water vapor partial pressure inside a container, first, the container is fixed to the fixing part. As a result, the container is fixed between the light source and the measuring instrument. At this time, when the container to be measured is a container containing liquid inside, such as the first container 30L containing liquid, the positional relationship of the light source, the measuring instrument, and the container is determined so that the laser light emitted from the light source passes through the space of the container that does not contain liquid and reaches the measuring instrument. When the container to be measured is the first container 30L containing liquid in a state in which the container is contained in the second container 40, the part of the second container 40 through which the laser light emitted from the light source passes before reaching the measuring instrument is brought into close contact with the first container 30. As a result, the laser light can be made to pass through the inside of the first container 30L containing liquid and reach the measuring instrument without passing through the space outside the first container 30 and inside the second container 40. When the container to be measured is the second container 40 containing the first container 30L containing liquid therein, the positional relationship between the light source, the measuring device, the first container 30L containing liquid, and the second container 40 is determined so that the laser light does not pass through the first container 30L containing liquid, but passes through the second container 40 to reach the measuring device. During measurement, the positional relationship between the light source, the measuring device, and the container is fixed in a state in which the optical path length of the laser light being measured can be measured. This makes it possible to grasp the optical path length of the laser light being measured.

[0202] Next, a laser beam is emitted from the light source so that it passes through the container to be measured and reaches the measuring device. The laser beam has a wave number of 1400 cm. -1 A laser beam is irradiated near the container. Then, a measuring device is used to measure the water vapor partial pressure inside the container through which the laser beam passes. The temperature inside the container when the water vapor partial pressure is measured is also identified. The temperature inside the container during measurement is identified by the following method. The container to be measured is placed in the measurement environment, and then the container is left untouched for a sufficient amount of time before the laser beam is irradiated and the water vapor partial pressure is measured, so that the temperature outside the container and the temperature inside the container are equalized, and the water vapor partial pressure is measured. The temperature outside the container when the water vapor partial pressure is measured is then measured. The measured temperature outside the container is regarded as the temperature inside the container. The temperature outside the container when the water vapor partial pressure is measured is identified by measuring it with a temperature logger. The temperature logger used at this time is one that can be set to a resolution of 0.1°C, a measurement accuracy of ±0.5°C, and a measurement interval of 10 seconds. When measuring the humidity inside the container when the temperature inside the container is t°C, the temperature outside the container is kept at t±0.5°C. The water vapor partial pressure measured in the above environment is defined as the water vapor partial pressure at t°C.

[0203] The humidity inside the container is then calculated from the measured water vapor partial pressure. Specifically, this is calculated by dividing the water vapor partial pressure at temperature t°C inside the container by the saturated water vapor pressure at t°C. The saturated water vapor pressure at t°C is calculated using the Tetens formula (Equation (3) shown below).

number

[0204] More specifically, the humidity inside the container to be measured at t°C is calculated as follows. First, the water vapor partial pressure of the same container is measured seven times. Next, the maximum and minimum water vapor partial pressure values ​​obtained from the seven measurements are excluded, and each of the five measured water vapor partial pressure values ​​is divided by the saturated water vapor pressure at t°C. In this way, five values ​​are calculated as the humidity inside the container to be measured at t°C. The average of these five values ​​is taken as the humidity inside the measurement container at t°C.

[0205] The water vapor partial pressure inside the container to be measured can be measured using a calibration vial as follows. First, a laser beam is passed through a calibration vial whose internal water vapor partial pressure has been specified, and the absorbance of the laser beam is measured. This determines the relational expression between the internal water vapor partial pressure and the absorbance of the laser beam. Next, a laser beam is passed through the container to be measured, and the absorbance of the laser beam is measured. Then, the absorbance of the container to be measured is substituted into the relational expression between the internal water vapor partial pressure and the absorbance of the laser beam. This allows the water vapor partial pressure inside the container to be measured. Here, when calibration is performed using a calibration vial in measuring the water vapor partial pressure, if the optical path length of the laser beam differs between the container to be measured and the calibration vial, the water vapor partial pressure is calculated by the following method. When the container to be measured is irradiated with laser beam, the length of the portion of the optical path of the laser beam that passes through the inside of the container to be measured is set to L1. When the calibration vial is irradiated with laser beam, the length of the portion of the optical path of the laser beam that passes through the inside of the calibration vial is set to L2. The coefficient α is calculated by dividing L1 by L2. That is, a coefficient α is calculated, which can be expressed as α=L1 / L2. Then, as described above, the absorbance of the container to be measured is substituted into the equation relating to the internal water vapor partial pressure and the absorbance of the laser light, and the value obtained is multiplied by the coefficient α. The value calculated in this way is used as the water vapor partial pressure inside the container to be measured. By using the coefficient α in this way, it is possible to correct the deviation in the measured water vapor partial pressure caused by the difference in length between L1 and L2.

[0206] When measuring the humidity inside a container to be measured, if the humidity is measured multiple times at different times, the arrangement of the light source, container, and measuring instrument is made constant when the container is irradiated with laser light at different times. This makes it possible to make the optical path length of the laser light during measurement constant at different times. The irradiation area of ​​the laser light can also be made constant at different times. By fixing the container to the fixing part, the arrangement of the light source, container, and measuring instrument can be made constant. This makes it possible to measure absorbance under similar conditions at different times and calculate the humidity inside the container at different times. When measuring the humidity inside a container to be measured, if there are multiple containers to be measured, the arrangement of the light source, container, and measuring instrument can be made constant when the laser light is irradiated to each of the multiple containers. This makes it possible to make the optical path length of the laser light during measurement constant between the multiple containers to be measured. The irradiation area of ​​the laser light can also be made constant between the multiple containers to be measured. By fixing the container to the fixing part, the arrangement of the light source, container, and measuring instrument can be made constant. This makes it possible to measure the absorbance of a plurality of containers under similar conditions and calculate the humidity inside the plurality of containers.

[0207] The water vapor permeability of the second container 40 is 15(g / (m 2 ·day) or less. This can reduce the amount of water that moves Aa from inside the second container 40 through the second container 40 and leaks out of the second container 40. This allows the humidity inside the second container 40 to be maintained at a high value. In particular, the humidity inside the second container 40 can be maintained at 80% RH or higher. This can reduce the amount of reduction in the water contained in the liquid L contained in the first container 30.

[0208] In the present embodiment, the second container 40 is a film container that forms a storage space S between the first film 41a and the second film 41b. The water vapor permeability of such a film container is measured in accordance with JIS K7129-2:2019. The water vapor permeability of the film container is measured using a PERMATRAN (3 / 33), a permeability measuring device manufactured by MOCON, Inc., USA, in an environment of a temperature of 40°C and a humidity of 90% RH.

[0209] The water vapor transmission rate of the first container 30 may be 5.4 (mg / day) or less in an atmosphere with a temperature of 40° C. and a humidity of 90% RH. This can reduce the amount of water that permeates the first container 30 and leaks out of the first container 30 (transition B). This can reduce the amount of water lost from the liquid L contained in the first container 30.

[0210] The water vapor permeation rate of the first container 30 in an atmosphere with a temperature of 40°C and a humidity of 90% RH can be measured by setting the temperature of the measurement environment to 40°C and the humidity to 90% RH and performing the above-mentioned method for measuring the water vapor permeation rate of a container.

[0211] In the embodiment described above, the liquid-containing combination container 10L includes a first container 30 that contains a liquid L containing water in a container section 31 and includes a permeation section 35 having oxygen permeability, a second container 40 that contains the first container 30 and has oxygen barrier properties, and an oxygen absorbent 21 that absorbs oxygen in the second container 40. The water vapor transmission rate of the first container 30 is 2.75 (mg / day) or less in an atmosphere at a temperature of 20°C and a humidity of 85% RH. The humidity in the second container 40 is maintained at 80% RH or more. This makes it possible to reduce the amount of water lost in the liquid L contained in the first container 30.

[0212] The liquid-filled combination container 10L may include a water-donating agent 27 that releases water into the inside of the second container 40. In the liquid-filled combination container 10L, the water-donating agent 27 may be located outside the first container 30 and inside the second container 40. In the liquid-filled combination container 10L, the water-donating agent 27 may release water into the inside of the second container 40 in an atmosphere with a temperature of 20° C. and a humidity of 80% RH. This increases the humidity in the second container 40 and allows it to be maintained at 80% RH or higher.

[0213] In the liquid-containing combination container 10L, the water-donating agent 27 may increase the humidity inside the second container 40 by 1% RH or more when the atmosphere inside the second container 40 is left for 6 hours at a temperature of 20°C and a humidity of 80% RH. This makes it possible to more stably maintain the humidity inside the second container 40 at 80% RH or more, even when the above-mentioned water movements Aa and Ab are taken into consideration. Furthermore, the humidity inside the second container 40 can also be maintained at a value greater than 80% RH.

[0214] In the liquid-containing combination container 10L, the liquid L may be a medicine. According to the liquid-containing combination container 10L of the present embodiment, even when the liquid L is a medicine, deterioration of the liquid L due to oxygen can be suppressed. Furthermore, the amount of water lost in the liquid L, which is a medicine, can be reduced.

[0215] In the liquid-containing combination container 10L, the mass B2 (mg / day) of water vapor passing through the first container 30 and moving from the inside to the outside of the first container 30 per day in a state in which the amount of water vapor inside the second container 40 has reached equilibrium may be 0.14 (mg / day) or less. This makes it possible to sufficiently reduce the amount of water leaking from the first container 30 until a predetermined time has elapsed since the amount of water vapor inside the second container 40 has reached equilibrium.

[0216] In the liquid-containing combination container 10L, the elapsed time DA (days) from an initial state in which the temperature is 20°C, the humidity inside the first container 30 is 100% RH, and the humidity inside and outside the second container 40 are 40% RH until the amount of water vapor inside the second container 40 reaches equilibrium may be 3 (days) or less. This makes it possible to reduce the amount of water leaking from the first container 30 until a predetermined time has passed since the second container 40 is closed.

[0217] In the liquid-containing combination container 10L, the elapsed time DA (days), the mass E (mg) of water vapor that passes through the first container 30 and moves from the inside to the outside of the first container 30 during the elapsed time DA (days) from the initial state, and the above-mentioned B2 (mg / day) may satisfy the following formula (1). This allows the amount of water contained in the liquid L to decrease to 2 mg or less until 14 days have passed since the second container 40 is closed.

number

[0218] In the liquid-containing combination container 10L, when the inside of the second container 40 is in an atmosphere with a temperature of 20° C. and a humidity of 80% RH, and the outside of the second container 40 is in an arbitrary atmosphere with a temperature of 20° C. and a humidity of 40% RH or more and 50% RH or less, the total mass per day of water vapor passing through the second container 40 and water vapor absorbed by the second container 40 inside the second container 40, A1 (mg / day) may be 300 (mg / day) or less. This makes it possible to more stably maintain the humidity inside the second container 40 at 80% RH or more when the humidity outside the second container 40 is approximately the same as the humidity in a normal room. Furthermore, the humidity inside the second container 40 can also be maintained at a higher value.

[0219] In the liquid-containing combination container 10L, when the inside of the first container 30 is in an atmosphere with a temperature of 20°C and a humidity of 95% RH, and the outside of the first container 30 is in an arbitrary atmosphere with a temperature of 20°C and a humidity of 80% RH or more and 95% RH or less, B1 (mg / day), which is the mass of water vapor permeating and moving through the first container 30 per day, may be 2.75 (mg / day) or less. This makes it possible to reduce the amount of reduction in water contained in the liquid L. B1 (mg / day) may be 0.32 (mg / day) or less.

[0220] In the liquid-containing combination container 10L, Ab1 (mg / day), which is the mass of water vapor absorbed by the second container 40 per day inside the second container 40 when the humidity inside the second container 40 is 80% RH and the temperature is 20°C, may be 20 (mg / day) or less. This makes it possible to more stably maintain the humidity inside the second container 40 at 80% RH or more. Furthermore, it is also possible to maintain the humidity inside the second container 40 at a higher value. Ab1 (mg / day) may be 10 (mg / day) or less.

[0221] In the liquid-containing combination container 10L, the first container 30 may have a container body 32 having an opening 33, and a plug 34 that closes the opening 33 and forms a permeable portion 35. This allows the plug 34 to promote the transfer of oxygen from the first container 30 to the second container 40.

[0222] In the liquid-containing combination container 10L, the plug 34 may contain silicone. This allows the permeable portion 35 to be formed by the plug 34.

[0223] The planned needle piercing portion 34g is a portion that is planned to be pierced by the needle of a syringe. The planned needle piercing portion 34g is a portion that is planned to be pierced by a needle. The planned needle piercing portion 34g is located in a portion of the stopper 34 that faces the opening 33. The planned needle piercing portion 34g may be exposed from the fixing device 36. That is, the planned needle piercing portion 34g may not be covered by the fixing device 36. As shown in FIG. 1C, the planned needle piercing portion 34g may be a portion of the stopper 34 that faces the opening 33 where the thickness is the smallest. The planned needle piercing portion 34g may be a portion located at the center of the stopper 34 that faces the opening 33. As shown in FIG. 1C, the planned needle piercing portion 34g may be visible by a convex portion 34ga or a concave portion. The planned needle piercing portion 34g may be a portion surrounded by a plurality of convex portions 34ga or concave portions. The intended needle piercing portion 34g may be a portion surrounded by linear convex portions 34ga or concave portions. The linear convex portions 34ga or concave portions may extend circumferentially. The linear convex portions 34ga or concave portions may extend circumferentially. The intended needle piercing portion 34g may be located on an extension line of the linear convex portions 34ga or concave portions. The intended needle piercing portion 34g may be located on an extension line of the linear convex portions 34ga or concave portions.

[0224] Although the embodiment has been described with reference to the specific example, the above-mentioned specific example does not limit the embodiment. The above-mentioned embodiment can be embodied in various other specific examples, and various omissions, substitutions, changes, additions, etc. can be made without departing from the spirit of the embodiment.

[0225] The first container 30 may include a label 37 (see FIG. 1A). The label 37 may indicate information about the liquid L. The label 37 may be attached to the container body 32. The label 37 may not be attached to the entire circumference so that the inside of the container body 32 can be observed. The label 37 may face the second container 40 so that the description on the label 37 can be observed. When the first container 30 is a vial, 10 mm or more, preferably 20 mm or more of the container body 32 may be exposed between the label 37 and the stopper 34 and the fixture 36. The liquid L in the first container 30 can be observed through the transparent container body 32. The amount of oxygen in the first container 30 can be measured by irradiating light through the transparent container body 32. In this case, in addition to the neck portion 32c of the container body 32, the body portion 32b may be exposed between the label 37 and the stopper 34 and the fixture 36.

[0226] In order to maintain the relative position between the oxygen reactant 20 or the water donor 27 and the permeation part 35 of the first container 30, the oxygen reactant 20 or the water donor 27 may be fixed to the first container 30 using heat sealing or a bonding material. The oxygen reactant 20 or the water donor 27 may be fixed to a part other than the permeation part 35 of the first container 30. When the plug 34 forms the permeation part 35, the oxygen reactant 20 or the water donor 27 may be fixed to a part of the plug 34. When the plug 34 forms the permeation part 35, the oxygen reactant 20 or the water donor 27 may be fixed to the fixing tool 36 or a part of the plug 34 so that a gap is secured between the second container 40 and the plug 34. According to these configurations, an appropriate relative positional relationship between the oxygen reactant 20 or the water donor 27 and the permeation part 35 of the first container 30 is maintained, and the transfer of oxygen from the inside to the outside of the first container 30 can be stably promoted.

[0227] In the example shown in FIG. 4D and FIG. 4F, the container body 32 and the fixing tool 36 have oxygen barrier properties, and the plug 34 forms the transmission part 35. In the example shown by the two-dot chain line in FIG. 4D and FIG. 4F, the oxygen reactant 20 is arranged facing the plug 34 having oxygen permeability. The oxygen reactant 20 may contact the plug 34 forming the transmission part 35. The oxygen reactant 20 may contact only a part of the plug 34 having oxygen permeability. The oxygen reactant 20 may be arranged with a gap between it and the plug 34 having oxygen permeability. The oxygen reactant 20 shown by the two-dot chain line in FIG. 4D and FIG. 4F can promote the movement of oxygen from the inside to the outside of the first container 30. In addition, the second container 40 having flexibility and oxygen barrier properties can be prevented from contacting the plug 34 forming the transmission part 35.

[0228] The form of the fixing device 36 that prevents the plug 34 from coming off the container body 32 is not limited to the form shown in FIG. 1C. FIG. 10 is a plan view showing an example of the fixing device 36 in a modified example, as viewed from the side where the container body 32 is located in the first direction D1. FIG. 11 is a cross-sectional view showing the fixing device 36 shown in FIG. 10 cut along the line XI-XI. FIG. 12 is a plan view showing an example of the fixing device 36 in a modified example, different from the examples shown in FIG. 10 and FIG. 11, as viewed from the side where the container body 32 is located in the first direction D1. FIG. 13 is a cross-sectional view showing the fixing device 36 shown in FIG. 12 cut along the line XIII-XIII.

[0229] The fixture 36 shown in Figs. 10 and 11 and the fixture 36 shown in Figs. 12 and 13 have a resin lid 361 and a metal member 362. The metal member 362 is a folded plate-like member made of aluminum. The lid 361 and the metal member 362 are overlapped in the first direction D1. The fixture 36 is attached to the head 32d of the container body 32 with the side on which the metal member 362 is located facing the stopper 34. As a result, in the liquid-containing combination container 10L, the stopper 34, the metal member 362, and the lid 361 are overlapped in this order. The fixture 36 is attached to the head 32d of the container body 32 by being crimped to the head 32d.

[0230] In the fastener 36 shown in Figs. 10 and 11, the metal member 362 has an engagement portion 363 that engages with the lid 361, and a perforation 364 that surrounds the engagement portion 363 when observed from the first direction D1. When the fastener 36 is fastened to the head 32d of the container body 32, the portion of the metal member 362 surrounded by the perforation 364 overlaps a part of the plug 34. With regard to the fastener 36 shown in Figs. 10 and 11, when the lid 361 is peeled off from the fastener 36 fastened to the head 32d of the container body 32, the portion of the metal member 362 surrounded by the perforation 364 is pulled by the lid 361 via the engagement portion 363. This causes the metal member 362 to break along the perforation 364. For this reason, when the lid 361 is peeled off from the fastener 36 that is crimped to the head 32d of the container body 32, an opening is formed in the metal member 362 along the perforation 364. By inserting a needle 64 of a syringe 60 as shown in Fig. 8 into the stopper 34 through the opening, the liquid L can be taken out from the liquid-containing first container 30L.

[0231] In the fixture 36 shown in Figs. 12 and 13, the metal member 362 has an opening 365. When the fixture 36 is crimped to the head 32d of the container body 32, the opening 365 of the metal member 362 overlaps with a part of the stopper 34. The lid 361 has a claw portion 366 that engages with the opening 365 of the metal member 362. With regard to the fixture 36 shown in Figs. 12 and 13, when the lid 361 is peeled off from the fixture 36 that is crimped to the head 32d of the container body 32, the claw portion 366 disengages from the opening 365. This exposes the opening 365. By inserting the needle 64 of a syringe 60 as shown in Fig. 8 into the stopper 34 through the opening 365, the liquid L can be taken out from the liquid-containing first container 30L. EXAMPLES

[0232] The above-described embodiment will be described in more detail below using examples, but the above-described embodiment is not limited to these examples.

[0233] <Example 1> A vial bottle with a capacity of about 9.2 mL was prepared as the first container. The first container had a configuration shown in FIG. 1C. The vial bottle constituting the first container had a glass container body. A liquid with a capacity of about 1.0 mL was contained in the first container. The liquid contained in the first container was a liquid containing water, propylene glycol, and mannitol in a mass ratio of 92.5:5.0:2.5. The opening of the container body containing the liquid was closed with a rubber stopper. The rubber stopper was made of silicone rubber. The thickness of the rubber stopper (the dimension of the rubber stopper in the direction in which the rubber stopper is inserted into the opening of the container body) was 2.7 mm. A vial winding machine ("VM-NS007" manufactured by Naigai Glass Industries Co., Ltd.) was used to fix a fixture ("AP Cap" manufactured by Ishida Press Kogyo Co., Ltd.) as shown in FIG. 12 and FIG. 13 to the head of the container body to prepare a first container containing liquid. That is, the fixing device prevented the rubber stopper from coming off the container body. After sealing using the fixing device, the space between the container body and the rubber stopper became airtight. A head space not filled with liquid remained in the first container. The second container was closed in a room with a temperature of 20°C and a humidity of 40% RH or higher and 50% RH or lower. Therefore, air was contained in the second container. It is considered that the humidity in the second container immediately after closing the second container is equal to the humidity in the room in which the second container was closed.

[0234] The liquid-filled combination container shown in Figures 1A and 1B was produced using the liquid-filled first container described above. The second container included a first film and a second film. The materials of the first film and the second film of the second container had the following layer structure. IB-PET-PXB2 / ON / IB-PET-PXB2 / CPP

[0235] "IB-PET-PXB2" is a 12 μm thick film available from Dai Nippon Printing Co., Ltd. "ON" is "Emblem ONMB-RT" 15 μm thick available from Unitika Ltd. "CPP" is an unstretched polypropylene film ("TPF-4" 30 μm thick available from Okamoto Corporation). The meanings of "IB-PET-PXB2", "ON" and "CPP" are the same in the description of the examples and comparative examples described below. The water vapor transmission rate of the material of the first film and the second film is 0.025 g / (m 2 The first and second films had a length of 18 cm in the first direction and a length of 11 cm in the second direction when flatly developed. The width of the sealed portion was 10 mm. The inner surface area of ​​the second container 40 was 250 cm 2 As shown in Figures 1A and 1B, the first container was placed inside the second container with the container body facing the curved first seal portion.

[0236] As shown in FIG. 1A and FIG. 1B, an oxygen absorbent and an oxygen detector were placed as oxygen reactants in a position facing the stopper of the first container. Diatomaceous earth was incorporated inside the oxygen absorbent as a water donor. Therefore, by placing the oxygen absorbent in a position facing the stopper of the first container, the water donor was also placed in a position facing the stopper of the first container. The oxygen absorbent was Ageless "ZH-100" available from Mitsubishi Gas Chemical Company, Inc. The oxygen absorbent was capable of absorbing 100 mL of oxygen. The oxygen detector was Ageless Eye "Eye-LS" available from Mitsubishi Gas Chemical Company, Inc.

[0237] All of the materials and members used in the first container in Example 1 were sterilized. In this manner, the liquid-containing combination container of Example 1 was manufactured.

[0238] <Humidity in the second container> The humidity maintained in the second container was measured for the liquid-containing combination container of Example 1. In other words, the humidity in the second container was measured when the amount of water vapor inside the second container reached equilibrium. The measurement method employed was the method of measuring the humidity inside the container using a head space analyzer (Lighthouse head space analyzer FMS760) as described above in this specification. In measuring the humidity, a 12-hour period was allowed from when the container to be measured was placed in the measurement environment until the laser light was irradiated and the absorbance was measured. This resulted in the temperature outside the container being considered to be equal to the temperature inside the container. The humidity was measured continuously in real time, and when the increase in humidity inside the second container stopped, it was considered that the amount of water vapor inside the second container had reached equilibrium. The humidity inside the second container in this state was then identified.

[0239] As a result of measuring the humidity inside the second container, when the amount of water vapor inside the second container reached equilibrium in the liquid-containing combination container of Example 1, the humidity inside the second container was 95.7% RH. Therefore, it was found that the humidity inside the second container was maintained at 80% RH or more in the liquid-containing combination container of Example 1.

[0240] <Water vapor transmission rate of the first container in an atmosphere at a temperature of 20°C and a humidity of 85% RH> For the liquid-containing combination container of Example 1, the water vapor transmission rate of the first container was measured in an atmosphere with a temperature of 20°C and a humidity of 85% RH. The water vapor transmission rate (mg / day) of the first container was measured by the following method. First, the first container was cut so as to separate the storage part of the first container into a first part and a second part. Next, calcium chloride was stored in the part of the first part that constituted the storage part in the first container. Next, aluminum foil was placed as a sealing member on the opening formed in the first part by cutting the container, and the first part and the sealing member were bonded together using a water-resistant adhesive. In this way, the opening formed in the first part was closed by the sealing member and the adhesive. The first part was left in an environment with a temperature of 20°C and a humidity of 85% RH for 10 days. Then, the total mass of the first part, the sealing member, the adhesive, and calcium chloride was measured at a first time t1, which was included in the 10 days and at least one day after the start of leaving the first part, and at a second time t2, which was included in the 10 days and was seven days after the first time t1. The difference between the total mass at the second time t2 and the total mass at the first time t1 was considered to be the mass of water that had permeated the first part and been absorbed by calcium chloride during the seven days from the first time t1 to the second time t2. Thus, the water vapor transmission rate (mg / day) of the first part was obtained by dividing the difference (mg) between the total mass at the second time t2 and the total mass at the first time t1 by 7 (days). Furthermore, the water vapor transmission rate (mg / day) of the second part was measured by the same method as that used to measure the water vapor transmission rate (mg / day) of the first part. The water vapor permeation rate (mg / day) through the first portion and the water vapor permeation rate (mg / day) through the second portion were added together to obtain the water vapor permeation rate (mg / day) through the first container.

[0241] As a result of measuring the water vapor transmission rate of the first container, the water vapor transmission rate of the first container was 0.91 (mg / day) in the liquid-containing combination container of Example 1. Therefore, it was found that the water vapor transmission rate of the first container in an atmosphere of a temperature of 20°C and a humidity of 85% RH in the liquid-containing combination container of Example 1 was 2.75 (mg / day) or less.

[0242] <Reduction in water content in liquid> The amount of water lost from the liquid in the liquid-containing combination container of Example 1 was measured. The amount of water lost from the liquid was measured by the following method. First, the liquid-containing combination container was left in an environment with a temperature of 20°C and a humidity of 65%RH until 14 days had passed since the second container was closed. Then, the amount of the mass of the first container that had been left for 14 days was measured to see how much it had decreased compared to before it was left. The decreased mass was considered to be the amount of water lost from the liquid in 14 days. If the mass of the first container had increased compared to before it was left for 14 days, it was evaluated that the amount of water lost from the liquid had increased. In this case, the increase in the mass of the first container was considered to be the amount of water lost from the liquid in 14 days.

[0243] <Example 2> As Example 2, a liquid-containing combination container was produced in the same manner as in Example 1, except for the points described below. In Example 2, the materials of the first film and the second film of the second container had the following layer structure. PET 12μm / AL 7μm / LDPE 40μm

[0244] "PET12μm" is polyethylene terephthalate ("E5102" having a thickness of 12μm, available from Toyobo Co., Ltd.). "AL7μm" ​​is a layer of aluminum having a thickness of 7μm, available from Toyo Aluminum K.K. "LDPE40μm" is low density polyethylene ("LL-MTNST" having a thickness of 40μm, available from Futamura Chemical Co., Ltd.). The meanings of "PET12μm", "AL7μm" ​​and "LDPE40μm" are the same in the description of the examples and comparative examples described below. The water vapor transmission rate of the material of the first film and the second film was 0.4mg / (m 2 ·day).

[0245] For the liquid-containing combination container of Example 2, the humidity inside the second container, the water vapor transmission rate of the first container, and the amount of water lost in the liquid were measured using methods similar to those used in Example 1.

[0246] As a result of measuring the humidity inside the second container, when the amount of water vapor inside the second container reached equilibrium in the liquid-containing combination container of Example 2, the humidity inside the second container was 96.2% RH. Therefore, it was found that the humidity inside the second container was maintained at 80% RH or more in the liquid-containing combination container of Example 2.

[0247] The water vapor transmission rate of the first container in the liquid-containing combination container of Example 2 is similar to that of Example 1. That is, in the liquid-containing combination container of Example 2, the water vapor transmission rate of the first container is 0.91 (mg / day). Therefore, it was found that in the liquid-containing combination container of Example 2, the water vapor transmission rate of the first container in an atmosphere at a temperature of 20°C and a humidity of 85% RH is 2.75 (mg / day) or less.

[0248] <Example 3> As Example 3, a liquid-containing combination container was produced in the same manner as in Example 1, except for the points described below. In Example 3, the materials of the first film and the second film of the second container had the following layer structure. PET 12μm / LDPE 40μm

[0249] The water vapor permeability of the material of the first film and the second film is 15 g / (m 2 ·day).

[0250] For the liquid-containing combination container of Example 3, the humidity inside the second container, the water vapor transmission rate of the first container, and the amount of water lost in the liquid were measured using the same methods as in Example 1.

[0251] As a result of measuring the humidity inside the second container, when the amount of water vapor inside the second container reached equilibrium in the liquid-containing combination container of Example 3, the humidity inside the second container was 83.5% RH. Therefore, it was found that the humidity inside the second container was maintained at 80% RH or more in the liquid-containing combination container of Example 3.

[0252] The water vapor transmission rate of the first container in the liquid-containing combination container of Example 3 is similar to that of Example 1. That is, in the liquid-containing combination container of Example 3, the water vapor transmission rate of the first container is 0.91 (mg / day). Therefore, it was found that in the liquid-containing combination container of Example 3, the water vapor transmission rate of the first container in an atmosphere at a temperature of 20°C and a humidity of 85% RH is 2.75 (mg / day) or less.

[0253] <Example 4> In Example 4, a liquid-containing combination container was manufactured in the same manner as in Example 1, except for the points described below. In Example 4, "FX100" available from Mitsubishi Gas Chemical Company, Inc. was used as the oxygen absorbent. The water donor used was one that was not incorporated inside the oxygen reactant. Specifically, a water-absorbing gel (water-absorbing beads of sodium polyacrylate) was placed in the second container as the water donor.

[0254] For the liquid-containing combination container of Example 4, the humidity inside the second container, the water vapor transmission rate of the first container, and the amount of water lost in the liquid were measured using methods similar to those used in Example 1.

[0255] As a result of measuring the humidity inside the second container, when the amount of water vapor inside the second container reached equilibrium in the liquid-containing combination container of Example 4, the humidity inside the second container was 99.3% RH. Therefore, it was found that the humidity inside the second container was maintained at 80% RH or more in the liquid-containing combination container of Example 4.

[0256] The water vapor transmission rate of the first container in the liquid-containing combination container of Example 4 is similar to that of Example 1. That is, in the liquid-containing combination container of Example 4, the water vapor transmission rate of the first container was 0.91 (mg / day). Therefore, it was found that in the liquid-containing combination container of Example 2, the water vapor transmission rate of the first container in an atmosphere at a temperature of 20°C and a humidity of 85% RH was 2.75 (mg / day) or less.

[0257] <Example 5> In Example 5, a liquid-containing combination container was produced in the same manner as in Example 1, except for the points described below. In Example 5, "FWS100" available from Iris Fine Products Co., Ltd. was used as the oxygen absorbent. A water donor was incorporated inside the oxygen absorbent.

[0258] For the liquid-containing combination container of Example 5, the humidity inside the second container, the water vapor transmission rate of the first container, and the amount of water lost in the liquid were measured using methods similar to those used in Example 1.

[0259] As a result of measuring the humidity inside the second container, when the amount of water vapor inside the second container reached equilibrium in the liquid-containing combination container of Example 5, the humidity inside the second container was 84.6% RH. Therefore, it was found that the humidity inside the second container was maintained at 80% RH or more in the liquid-containing combination container of Example 5.

[0260] The water vapor transmission rate of the first container in the liquid-containing combination container of Example 5 is similar to that of Example 1. That is, in the liquid-containing combination container of Example 5, the water vapor transmission rate of the first container was 0.91 (mg / day). Therefore, it was found that in the liquid-containing combination container of Example 5, the water vapor transmission rate of the first container in an atmosphere at a temperature of 20°C and a humidity of 85% RH was 2.75 (mg / day) or less.

[0261] <Example 6> In Example 6, a liquid-filled combination container was produced in the same manner as in Example 1, except for the points described below. In Example 6, the opening of the container body of the first container was closed with the film used as the material for the first and second films of the second container in Example 3. Then, the film was fixed to the opening of the container body using a silicone O-ring and an aluminum fastener.

[0262] For the liquid-containing combination container of Example 6, the humidity inside the second container, the water vapor transmission rate of the first container, and the amount of water lost in the liquid were measured using the same methods as in Example 1.

[0263] As a result of measuring the humidity inside the second container, when the amount of water vapor inside the second container reached equilibrium in the liquid-containing combination container of Example 6, the humidity inside the second container was 91.8% RH. Therefore, it was found that the humidity inside the second container was maintained at 80% RH or more in the liquid-containing combination container of Example 6.

[0264] As a result of measuring the water vapor transmission rate of the first container, the water vapor transmission rate of the first container was 0.72 (mg / day) in the liquid-containing combination container of Example 6. Therefore, it was found that the water vapor transmission rate of the first container in an atmosphere of a temperature of 20° C. and a humidity of 85% RH in the liquid-containing combination container of Example 6 was 2.75 (mg / day) or less.

[0265] <Comparative Example 1> As Comparative Example 1, a liquid-containing combination container was manufactured in the same manner as in Example 1, except for the points described below. In Comparative Example 1, the opening of the container body of the first container was closed with a lid manufactured by DuPont (product name "Tyvek (registered trademark) 1059B"). Then, the lid was fixed to the opening of the container body using a silicone O-ring and an aluminum fastener.

[0266] For the liquid-containing combination container of Comparative Example 1, the humidity inside the second container, the water vapor transmission rate of the first container, and the amount of water lost from the liquid were measured using methods similar to those used in Example 1.

[0267] As a result of measuring the humidity inside the second container, when the amount of water vapor inside the second container reached equilibrium in the liquid-containing combination container of Comparative Example 1, the humidity inside the second container was 93.3% RH. Therefore, it was found that the humidity inside the second container was maintained at 80% RH or more in the liquid-containing combination container of Comparative Example 1.

[0268] As a result of measuring the water vapor transmission rate of the first container, the water vapor transmission rate of the first container was 122 (mg / day) in the liquid-containing combination container of Comparative Example 1. Therefore, it was found that in the liquid-containing combination container of Example 2, the water vapor transmission rate of the first container in an atmosphere of a temperature of 20°C and a humidity of 85% RH did not become 2.75 (mg / day) or less.

[0269] <Comparative Example 2> As Comparative Example 2, a liquid-containing combination container was produced in the same manner as in Example 1, except for the points described below. In Comparative Example 2, the opening of the container body of the first container was closed with a rubber stopper. The rubber stopper was made of silicone rubber. The thickness of the rubber stopper (the dimension of the rubber stopper in the direction in which the rubber stopper is inserted into the opening of the container body) was 0.5 mm.

[0270] For the liquid-containing combination container of Comparative Example 2, the humidity inside the second container, the water vapor transmission rate of the first container, and the amount of water lost from the liquid were measured using methods similar to those used in Example 1.

[0271] As a result of measuring the humidity inside the second container, when the amount of water vapor inside the second container reached equilibrium in the liquid-containing combination container of Comparative Example 2, the humidity inside the second container was 92.9% RH. Therefore, it was found that the humidity inside the second container was maintained at 80% RH or more in the liquid-containing combination container of Comparative Example 2.

[0272] As a result of measuring the water vapor transmission rate of the first container, the water vapor transmission rate of the first container was 4.48 (mg / day) in the liquid-containing combination container of Comparative Example 2. Therefore, it was found that in the liquid-containing combination container of Comparative Example 2, the water vapor transmission rate of the first container in an atmosphere at a temperature of 20°C and a humidity of 85% RH did not become 2.75 (mg / day) or less.

[0273] <Comparative Example 3> As Comparative Example 3, a liquid-containing combination container was manufactured by the same method as in Example 1, except for the points described below. In Comparative Example 3, "Z20PK Ya" available from Mitsubishi Gas Chemical Company, Inc. was used as the oxygen absorbent. Diatomaceous earth was incorporated inside the oxygen absorbent as a water donor. The amount of diatomaceous earth incorporated in "Z20PK Ya" used in Comparative Example 3 was less than the amount of diatomaceous earth incorporated in "ZH-100" used in Example 1. For this reason, it was expected that the humidity in the second container would be less likely to increase in Comparative Example 3 than in Example 1.

[0274] For the liquid-containing combination container of Comparative Example 3, the humidity inside the second container, the water vapor transmission rate of the first container, and the amount of water lost from the liquid were measured using methods similar to those used in Example 1.

[0275] As a result of measuring the humidity inside the second container, when the amount of water vapor inside the second container reached equilibrium in the liquid-containing combination container of Comparative Example 3, the humidity inside the second container was 75.1% RH. Therefore, it was found that the humidity inside the second container of Comparative Example 3 could not be maintained at 80% RH or higher.

[0276] The water vapor transmission rate of the first container in the liquid-containing combination container of Comparative Example 3 was similar to that of Example 1. That is, in the liquid-containing combination container of Comparative Example 3, the water vapor transmission rate of the first container was 0.91 (mg / day). Therefore, it was found that in the liquid-containing combination container of Comparative Example 3, the water vapor transmission rate of the first container in an atmosphere at a temperature of 20°C and a humidity of 85% RH was 2.75 (mg / day) or less.

[0277] <Comparative Example 4> In Comparative Example 4, a liquid-containing combination container was produced in the same manner as in Example 1, except for the following points. In Comparative Example 4, "FX" available from Mitsubishi Gas Chemical Company, Inc. was used as the oxygen absorbent. In Comparative Example 4, no water donor was used.

[0278] For the liquid-containing combination container of Comparative Example 4, the humidity inside the second container, the water vapor transmission rate of the first container, and the amount of water lost from the liquid were measured using methods similar to those used in Example 1.

[0279] As a result of measuring the humidity inside the second container, the amount of water vapor inside the second container did not reach equilibrium even after 14 days had passed since the second container was closed in the liquid-containing combination container of Comparative Example 4. The humidity inside the second container after 14 days had passed was 57.1% RH.

[0280] The water vapor transmission rate of the first container in the liquid-containing combination container of Comparative Example 4 was similar to that of Example 1. That is, in the liquid-containing combination container of Comparative Example 4, the water vapor transmission rate of the first container was 0.91 (mg / day). Therefore, it was found that in the liquid-containing combination container of Comparative Example 4, the water vapor transmission rate of the first container in an atmosphere at a temperature of 20°C and a humidity of 85% RH was 2.75 (mg / day) or less.

[0281] <Water vapor permeability of the second container> For the liquid-filled combination containers of Examples 1 to 6 and Comparative Examples 1 to 4, the water vapor transmission rate of the second container was further measured in an atmosphere at a temperature of 40° C. and a humidity of 90% RH.

[0282] More specifically, the water vapor permeability of the second container was measured in accordance with JIS K7129-2: 2019. The water vapor permeability of the second container was measured using a PERMATRAN (3 / 33), a permeability measuring device manufactured by MOCON, USA, in an environment of a temperature of 40°C and a humidity of 90% RH.

[0283] <Water vapor transmission rate of the first container in an atmosphere at a temperature of 40°C and a humidity of 90% RH> The water vapor transmission rate of the first container was measured in an atmosphere at a temperature of 40° C. and a humidity of 90% RH for the liquid-filled combination containers of Examples 1 to 5, Comparative Example 1, Comparative Example 3, and Comparative Example 4. The water vapor transmission rate of the first container in an atmosphere at a temperature of 40° C. and a humidity of 90% RH was measured in the same manner as the water vapor transmission rate of the first container in an atmosphere at a temperature of 20° C. and a humidity of 85% RH, except that the measurement was performed in an environment at a temperature of 40° C. and a humidity of 90% RH.

[0284] Table 1 shows the results of measuring the humidity inside the second container, the water vapor transmission rate of the first container in an atmosphere at a temperature of 20° C. and a humidity of 85% RH, and the amount of water lost from the liquid, for the liquid-containing combination containers of Examples 1 to 6 and Comparative Examples 1 to 4. Table 2 shows the results of measuring the water vapor transmission rate of the second container and the water vapor transmission rate of the first container in an atmosphere at a temperature of 40° C. and a humidity of 90% RH, for the liquid-containing combination containers of Examples 1 to 6 and Comparative Examples 1 to 4. In Table 1, "x" in the "Measurement Results" column of "Humidity Inside the Second Container" means that the amount of water vapor inside the second container did not reach equilibrium even after 14 days had passed since the second container was closed. "◯" in the "Evaluation" column of "Humidity Inside the Second Container" means that the humidity inside the second container was evaluated to be maintained at 80% RH or higher. "x" in the "Evaluation" column of "Humidity Inside the Second Container" means that the humidity inside the second container was evaluated to be not maintained at 80% RH or higher. A "-" in the "Evaluation" column of "Humidity in the second container" means that the amount of water vapor inside the second container did not reach equilibrium, and therefore it was not possible to evaluate whether the humidity in the second container was maintained at 80% RH or higher. A "〇" in the "Evaluation" column of "Water vapor transmission rate of the first container in an atmosphere of 20°C and 85% RH" means that the water vapor transmission rate of the first container in an atmosphere of 20°C and 85% RH was evaluated to be 2.75 (mg / day) or lower. A "X" in the "Evaluation" column of "Water vapor transmission rate of the first container in an atmosphere of 20°C and 85% RH" means that the water vapor transmission rate of the first container in an atmosphere of 20°C and 85% RH was evaluated not to be 2.75 (mg / day) or lower. A negative value (a value marked with a "-") in the "Reduction in water content of the liquid" column indicates the increase in water when it is evaluated that the water contained in the liquid has increased in the measurement of the reduction in water content of the liquid. In Table 2, a "-" in the column "Water vapor transmission rate of the first container in an atmosphere at a temperature of 40°C and a humidity of 90% RH" means that the water vapor transmission rate of the first container in an atmosphere at a temperature of 40°C and a humidity of 90% RH was not measured.

[0285] [Table 1]

[0286] [Table 2]

[0287] It is also possible to combine the multiple components disclosed in the above embodiment and modified examples as necessary. Alternatively, some components may be deleted from all the components shown in the above embodiment and modified examples. [Explanation of symbols]

[0288] 10L: liquid-containing combination container, 10: combination container, 20: oxygen reactant, 21: oxygen absorber, 22: oxygen absorber body, 22a: packaging body, 23: oxygen absorbing film, 27: water donor, 28: oxygen detector, 30L: liquid-containing first container, 30: first container, 30b: outer surface, 31: container section, 31a: contact area, 32: container body, 33: opening, 34: plug, 35: permeable section, 36: fixture, 40: second container, 40a: Opening, 41a: first film, 41b: second film, 41c: first gusset film, 41d: second gusset film, 42: container body, 44: lid, 60: syringe, 62: cylinder, 63: cylinder body, 64: needle, 66: piston, 67: piston body, 68: gasket, 70: test container, 71: partition wall, 72: main wall, 72A: through hole, 73: barrier bonding material, 74: lid, L: liquid

Claims

1. A first container that contains a liquid including water in a container portion and includes a permeation portion having oxygen permeability; a second container that houses the first container and has oxygen barrier properties; an oxygen absorbent that absorbs oxygen in the second container; The water vapor transmission rate of the first container is 2.75 (mg / day) or less in an atmosphere having a temperature of 20° C. and a humidity of 85% RH; The liquid-containing combination container, wherein the humidity in the second container is maintained at 80% RH or higher.

2. 10. The liquid combination container of claim 1, further comprising a water donor that releases water into the interior of the second container.

3. 3. The liquid combination container of claim 2, wherein the water donor is located outside the first container and inside the second container.

4. 3. The liquid-containing combination container according to claim 2, wherein the water-donating agent releases water into the second container in an atmosphere having a temperature of 20° C. and a humidity of 80% RH.

5. 3. The liquid-containing combination container according to claim 2, wherein the water-donating agent increases the humidity inside the second container by 1% RH or more when the atmosphere inside the second container is left at a temperature of 20°C and a humidity of 80% RH for 6 hours.

6. The liquid combination container of claim 1 , wherein the liquid is a pharmaceutical product.

7. 2. The liquid-containing combination container according to claim 1, wherein B2 (mg / day), which is the mass of water vapor passing through the first container and moving from the inside to the outside of the first container per day when the amount of water vapor inside the second container has reached equilibrium, is 0.14 (mg / day) or less.

8. 2. The liquid-containing combination container according to claim 1, wherein the elapsed time DA (days) from an initial state in which the temperature is 20° C., the humidity inside the first container is 100% RH, and the humidity inside the second container and the humidity outside the second container are 40% RH until the amount of water vapor inside the second container reaches equilibrium is 3 (days) or less.

9. DA (day) is the elapsed time from an initial state in which the temperature is 20° C., the humidity inside the first container is 100% RH, and the humidity inside the second container and the humidity outside the second container are 40% RH until the amount of water vapor inside the second container reaches equilibrium; and A mass E (mg) of water vapor that passes through the first container and moves from the inside to the outside of the first container during an elapsed time DA (day) from the initial state; The liquid-containing combination container according to claim 1, wherein the mass per day of water vapor that passes through the first container and moves from the inside to the outside of the first container when the amount of water vapor inside the second container has reached equilibrium, B2 (mg / day), satisfies the following formula (1). [0010]

10. The water vapor permeability of the second container is 15 (g / (m) at a temperature of 40° C. and a humidity of 90% RH. ２ 2. The liquid-containing combination container according to claim 1, wherein the liquid-containing combination container has a storage time of 100 minutes or less.

11. 2. The liquid-containing combination container according to claim 1, wherein the water vapor transmission rate of the first container is 5.4 (mg / day) or less in an atmosphere having a temperature of 40° C. and a humidity of 90% RH.

12. The liquid-containing combination container according to claim 1 , wherein the first container has a container body having an opening, and a plug that closes the opening and forms the transmission portion.

13. 13. The liquid combination container of claim 12, wherein the plug comprises silicone.

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