Oral composition

Abstract

To provide an oral composition having excellent fluoride ion retentivity and low mucosal irritancy.SOLUTION: An oral composition comprises: component (A) sodium fluoride; component (B) a water-soluble calcium salt; component (C) at least one selected from the group consisting of pyrophosphoric acid and alkali metal salts thereof; and component (D) at least one anionic surfactant selected from the group consisting of N-acyl taurine salts, N-acyl amino acid salts, and α-olefin sulfonate salts.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an oral composition.

Background Art

[0002] Fluorides such as sodium fluoride are widely used as medicinal components in oral compositions such as dentifrices because of their caries-preventive effect. In order to make fluoride act effectively, it is effective to retain fluoride ions on the oral mucosa and tooth surfaces for a long time, and it is desirable to leave a large amount of fluoride ions in the oral cavity even after rinsing the oral cavity with water or gargling after use. Patent Document 1 discloses an oral composition having high fluoride ion retention in the oral cavity, which contains a complex formed in an aqueous solution containing polyphosphate, calcium salt and fluoride salt.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] Anionic surfactants have higher detergency and foaming power than nonionic surfactants and amphoteric surfactants, and are widely used in oral compositions. Patent Document 1 also discloses an oral composition containing the above complex and sodium lauryl sulfate as an anionic surfactant. However, according to the study by the present inventor, the oral composition containing the above complex and sodium lauryl sulfate has room for improvement in mucosal irritation during use. Furthermore, when the oral composition is a chewing dentifrice, there is room for improvement in the texture after low-temperature storage.

[0005] An object of the present invention is to provide an oral composition having excellent fluoride ion retention and low mucosal irritation.

Means for Solving the Problems

[0006] As a result of intensive studies, the present inventors have found that by combining sodium fluoride, a water-soluble calcium salt, pyrophosphoric acid or its alkali metal salt, and a specific anionic surfactant, it is possible to enhance fluoride ion retention while suppressing mucosal irritation, and further suppress the deterioration of texture during low-temperature storage. The present invention is based on the above findings and has the following aspects.

[0007] <1> (A) component: sodium fluoride and, (B) component: a water-soluble calcium salt and, (C) component: at least one selected from the group consisting of pyrophosphoric acid and its alkali metal salts, and (D) component: at least one anionic surfactant selected from the group consisting of N-acyltaurine salts, N-acylamino acid salts, and α-olefin sulfonates, An oral composition containing <2> The oral composition according to <1>, wherein the (B) component is at least one selected from the group consisting of calcium chloride, calcium glycerophosphate, calcium gluconate, calcium lactate, and calcium pantothenate. <3> The oral composition according to <1> or <2>, wherein the (C) component is at least one selected from the group consisting of pyrophosphoric acid, sodium pyrophosphate, and potassium pyrophosphate. <4> The oral composition according to any one of <1> to <3>, wherein the (D) component is at least one selected from the group consisting of N-acylmethyltaurine salts and N-acylsarcosine salts. <5> The oral composition according to any one of <1> to <4>, wherein the component (D) is at least one selected from the group consisting of sodium N-lauroylmethyltaurine and sodium N-lauroylsarcosine. <6> Let B be the molar amount (mmol) of the component (B) per 1 g of the oral composition. mmоl Let D be the mass ratio (% by mass) of the component (D) to the total mass of the oral composition. wt% When mmоl B wt% / D <7> The oral composition according to any one of <1> to <6>, which is a dentifrice.

Advantages of the Invention

[0008] According to the present invention, an oral composition excellent in fluoride ion retention and low mucosal irritation can be provided.

Modes for Carrying Out the Invention

[0009] In this specification, the "oral composition" means a composition mainly intended for use in the oral cavity. "Water-soluble" means that the solubility in water at 20°C is 1 g / 100 g or more. "~" indicating a numerical range means that the numerical values described before and after it are included as the lower limit value and the upper limit value.

[0010] 〔Oral Composition〕 The oral composition of the present invention contains a component (A), a component (B), a component (C), and a component (D).

[0011] <(Component A)> (A) component is sodium fluoride (NaF). By containing the component (A) in the oral composition, it is excellent in fluoride ion retention and low mucosal irritation. (A) component can use commercially available products.

[0012] <Component (B)> Component (B) is a water-soluble calcium salt. When the liquid oral composition contains Component (B), it is excellent in fluoride ion retention and low mucosal irritation.

[0013] Examples of Component (B) include calcium chloride, calcium nitrate, calcium acetate, calcium citrate, calcium glycerophosphate, calcium gluconate, calcium benzoate, calcium formate, calcium fumarate, calcium lactate, calcium butyrate, calcium isobutyrate, calcium malate, calcium maleate, calcium propionate, calcium valerate, calcium pantothenate, and the like. As Component (B), at least one selected from the group consisting of calcium chloride, calcium glycerophosphate, calcium gluconate, calcium lactate, and calcium pantothenate is preferable. Component (B) may be used alone or in combination of two or more. Commercially available products can be used as Component (B).

[0014] <Component (C)> Component (C) is at least one selected from the group consisting of pyrophosphoric acid and its alkali metal salts. When the oral composition contains Component (C), it is excellent in fluoride ion retention and texture after storage at low temperature.

[0015] Examples of the alkali metal salts include sodium salts and potassium salts. As Component (C), from the viewpoint of fluoride ion retention, at least one selected from the group consisting of pyrophosphoric acid, sodium pyrophosphate, and potassium pyrophosphate is preferable, and at least one selected from the group consisting of potassium pyrophosphate and sodium pyrophosphate is particularly preferable. Component (C) may be used alone or in combination of two or more. Commercially available products can be used as Component (C).

[0016] <Component (D)> The component (D) is at least one anionic surfactant selected from the group consisting of N-acyltaurine salts, N-acylamino acid salts, and α-olefin sulfonates. By containing the component (D) in the oral composition, it is excellent in fluorine ion retention, low irritation to mucous membranes, and texture after low-temperature storage.

[0017] The number of carbon atoms of the acyl group in the N-acyltaurine salt is preferably 10 to 20. As the salt, alkali metal salts such as sodium salt and potassium salt are preferable, and sodium salt is more preferable. Examples of the N-acyltaurine salt include N-acylmethyltaurine salts such as sodium N-cocoyl methyltaurine, potassium N-cocoyl methyltaurine, sodium N-lauroyl methyltaurine, sodium N-stearoyl methyltaurine, sodium N-myristoyl methyltaurine, sodium N-oleoyl methyltaurine, and sodium N-palmitoyl methyltaurine, and sodium N-cocoyl taurine. Among these, N-acylmethyltaurine salts are preferable, and sodium N-acylmethyltaurine is more preferable.

[0018] The number of carbon atoms of the acyl group in the N-acylamino acid salt is preferably 8 to 18, more preferably 10 to 16. As the salt, alkali metal salts such as sodium salt and potassium salt are preferable, and sodium salt is more preferable. Examples of the N-acylamino acid salt include N-acyl acidic amino acid salts such as N-acylglutamate and N-acylaspartate; N-acyl neutral amino acid salts such as N-acylsarcosine salt, N-acylmethylalanine salt, N-acylglycine salt, and N-acylalanine salt; and acyl basic amino acid salts such as N-acylarginine ethyl ester salt. Among these, N-acyl neutral amino acid salts are preferable, and N-acylsarcosine salt is more preferable. As the N-acyl sarcosine salt, those having an acyl group with the above number of carbon atoms are preferred, and examples thereof include N-cocoyl sarcosine salt, N-lauroyl sarcosine salt, N-palmitoyl sarcosine salt and the like. Among these, sodium N-lauroyl sarcosine is preferred.

[0019] The number of carbon atoms of the α-olefin sulfonate is preferably 8 to 18, more preferably 14 to 16. As the salt, alkali metal salts such as sodium salt and potassium salt are preferred, and sodium salt is more preferred. As the α-olefin sulfonate, an α-olefin sulfonate having 14 carbon atoms, particularly a sodium salt (common name: sodium tetradecene sulfonate) is preferred.

[0020] As the component (D), at least one selected from the group consisting of N-acyl taurine salts and N-acyl amino acid salts is preferred from the viewpoint of more excellent low mucosal irritation, and at least one selected from the group consisting of N-acyl methyl taurine salts and N-acyl sarcosine salts is more preferred. At least one selected from the group consisting of sodium N-lauroyl methyl taurine and sodium N-lauroyl sarcosine is even more preferred. The component (D) may be used alone or in combination of two or more. Commercially available products can be used as the component (D).

[0021] <Content of each component> The content of the component (A) is preferably 0.09 to 1.3% by mass, more preferably 0.10 to 1.1% by mass based on the total mass of the oral composition. When the content of the component (A) is at least the above lower limit value, the fluorine ion retention property and low mucosal irritation are more excellent. When the content of the component (A) is at most the above upper limit value, the texture after low-temperature storage is more excellent.

[0022] The content of component (B) is preferably 0.02 to 5.0% by mass, more preferably 0.03 to 3.0% by mass, based on the total mass of the oral composition. When the content of component (B) is at least the above lower limit value, the fluorine ion retention property and low mucosal irritation property are more excellent. When the content of component (B) is at most the above upper limit value, the fluorine ion retention property and texture after low-temperature storage are more excellent.

[0023] The content of component (C) is preferably 0.02 to 3.0% by mass, more preferably 0.03 to 1.3% by mass, based on the total mass of the oral composition. When the content of component (C) is at least the above lower limit value, the fluorine ion retention property and texture after low-temperature storage are more excellent. When the content of component (C) is at most the above upper limit value, the low mucosal irritation property is more excellent.

[0024] The content of component (D) is preferably 0.001 to 10% by mass, more preferably 0.1 to 5% by mass, based on the total mass of the oral composition. When the content of component (D) is at least the above lower limit value, the fluorine ion retention property and texture after low-temperature storage are more excellent. When the content of component (D) is at most the above upper limit value, the fluorine ion retention property and low mucosal irritation property are more excellent. (D) component content is the B described later mmоl / D wt% It is preferably an amount such that the ratio represented by is within the preferred range described later.

[0025] The molar amount (mmol) of component (B) per 1 g of the oral composition is B mmоl , and when the mass ratio (% by mass) of component (D) to the total mass of the oral composition is D wt% , the ratio represented by B mmоl / D wt% is preferably 0.01 to 2.7, more preferably 0.03 to 2.3. When B mmоl / D wt% is at least the above lower limit value, the fluorine ion retention property and low mucosal irritation property are more excellent. When B mmоl / D wt% is at most the above upper limit value, the fluorine ion retention property and texture after low-temperature storage are more excellent.

[0026] The molar ratio of component (B) to component (A) (hereinafter also referred to as "(B) / (A)") is preferably from 0.005 to 10.0, more preferably from 0.01 to 5.0. When (B) / (A) is at least the above lower limit value, the fluorine ion retention property and the low mucosal irritation property are more excellent. When (B) / (A) is at most the above upper limit value, the fluorine ion retention property and the texture after low-temperature storage are more excellent.

[0027] The molar ratio of component (C) to component (A) (hereinafter also referred to as "(C) / (A)") is preferably from 0.005 to 2.1, more preferably from 0.01 to 2.1. When (C) / (A) is within the above range, the fluorine ion retention property is more excellent.

[0028] <Other components> The oral composition of the present invention may further contain other components other than the component (A), the component (B), the component (C) and the component (D), as long as the effects of the present invention are not impaired. The other components can be appropriately selected from known components in consideration of the dosage form, usage method, etc. of the oral composition. Examples of the other components include water, abrasive, binder, thickener, surfactant other than component (D), colorant, sweetener, preservative, fragrance, active ingredient, pH adjuster.

[0029] Examples of the abrasive include silica-based abrasives such as anhydrous silicic acid, precipitated silica, silica gel, aluminosilicate, zirconosilicate, dicalcium phosphate dihydrate and anhydrate, monocalcium phosphate, tricalcium phosphate, tetracalcium phosphate, calcium carbonate, calcium hydroxide, aluminum hydroxide, insoluble sodium metaphosphate, magnesium phosphate tribasic, magnesium carbonate. In particular, from the viewpoint of the expression of the effects of the present invention, silica-based abrasives are preferred. The content of the abrasive is preferably from 0 to 60% by mass, more preferably from 0 to 30% by mass, and may be 25% by mass or less, based on the total mass of the oral composition. The content of the abrasive being 0% by mass means that no abrasive is contained.

[0030] Examples of the binder include organic binders selected from water-soluble polymer substances such as cellulose derivatives such as sodium carboxymethyl cellulose, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, gums such as xanthan gum, tragacanth gum, karaya gum, gum arabic, and polyacrylates such as sodium polyacrylate, thickening silica, inorganic binders such as thickening aluminum silicate, Veegum, and laponite. The content of the binder is preferably 0.05 to 13.0% by mass based on the total mass of the oral composition. When the binder contains an organic binder, the blending amount of the organic binder is more preferably 0.1 to 3% by mass, and even more preferably 0.5 to 2.5% by mass based on the total mass of the oral composition. When the binder contains an inorganic binder, the content of the inorganic binder is more preferably 0 to 10.0% by mass, and even more preferably 0 to 8.0% by mass based on the total mass of the oral composition from the viewpoint of the adsorption property of fluoride ions to the tooth surface.

[0031] Examples of the thickener include sugar alcohols such as sorbitol, xylitol, erythritol, and maltitol, and polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol having an average molecular weight of 160 to 400 (average molecular weight described in the 2006 Specification of Quasi-Drug Ingredients). The content of the thickener is preferably 20 to 70% by mass, and more preferably 25 to 65% by mass based on the total mass of the oral composition.

[0032] Examples of the surfactant other than the component (D) include nonionic surfactants, anionic surfactants other than the component (D), and amphoteric surfactants. Examples of nonionic surfactants include glycerin fatty acid esters such as decaglycerin laurate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate (average number of moles of ethylene oxide added (hereinafter abbreviated as "E.O.") 20), alkyl glycosides having 12 to 16 carbon atoms in the alkyl group, sorbitan fatty acid esters such as sorbitan tristearate, sucrose fatty acid esters such as sucrose laurate, and polyoxyethylene alkyl ethers such as polyoxyethylene stearyl ether (E.O. 6). Examples of anionic surfactants other than component (D) include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, and sodium dodecylbenzenesulfonate and sodium lauryl sulfoacetate. Examples of amphoteric surfactants include coconut oil fatty acid amidopropyl betaine, lauryldimethylaminoacetic acid betaine, and N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine. The content of surfactants other than component (D) is, for example, 0 to 8.0% by mass based on the total mass of the oral composition. From the viewpoint of low irritation to mucous membranes, it is preferable that the oral composition does not contain an anionic surfactant other than component (D).

[0033] Examples of colorants include Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3, mica titanium, and titanium oxide. Examples of sweeteners include sodium saccharin, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, and perillartine. Examples of preservatives include paraoxybenzoic acid esters such as methyl paraben, ethyl paraben, and butyl paraben, and benzoic acid or its salts such as sodium benzoate.

[0034] Examples of the fragrance include natural fragrances such as peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, perilla oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, oregano oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweet tea oil, pomelo oil, iris concrete, absolute peppermint, absolute rose, orange flower, etc., and fragrances obtained by processing these natural fragrances (such as pre-cut, after-cut, fractional distillation, liquid-liquid extraction, essence formation, powder fragrance formation, etc.), menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramethane-3-carboxamide, pinene, octyl aldehyde, citral, pregeone, carvyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexanepropionate, methyl anthranilate, ethyl methylphenylglycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate and other single-component fragrances, strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor and other compound flavors. Known fragrance materials for oral compositions can be combined and used. The content of the fragrance is not particularly limited, but the content of the above fragrance materials is preferably 0.000001 to 1% by mass based on the total mass of the oral composition. The content of the flavoring fragrance using the above fragrance materials is preferably 0.05 to 2% by mass based on the total mass of the oral composition.

[0035] Examples of the active ingredients include bactericides such as isopropylmethylphenol and cetylpyridinium chloride; water-soluble phosphate compounds such as potassium salts and sodium salts of orthophosphoric acid (excluding component (C)); enzymes such as dextranase, mutanase, amylase, and protease; tranexamic acid, epsilon-aminocaproic acid, triclosan, lysozyme chloride, aluminum chlorohydroxyalanine, hinokitiol, ascorbic acid, tocopherol acetate, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene; water-soluble copper compounds such as copper chlorophyllin sodium, chlorophyll, and copper gluconate; aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid or its derivatives, glutyl lithic acid or its salts, glycyrrhetinic acid or its derivatives, and anti-calculus agents. The above active ingredients can be incorporated in an effective amount as long as the effects of the present invention are not impaired.

[0036] Examples of the pH adjuster include citric acid, tartaric acid, malic acid, and salts such as potassium salts and sodium salts thereof, and sodium hydroxide.

[0037] <Form, dosage form> The oral composition can be prepared in various forms such as liquid, paste, and solid. The dosage form of the oral composition is not particularly limited. The dosage form of the oral composition is typically an oral preparation that is discharged from the oral cavity after use. Examples of the oral preparation include dentifrices (liquid dentifrices, liquid dentifrices, paste dentifrices, lubricating dentifrices, powder dentifrices, etc.), mouthwashes, gargles, coating agents, mouth sprays, patches, sheet agents, sustained-release oral agents, chewing agents, orally dissolving agents, orally disintegrating agents, tongue care agents, oral refreshers, and denture care agents. Among the above, the oral composition of the present invention is suitable as a dentifrice, and particularly suitable as a paste dentifrice.

[0038] The oral composition of the present invention can be prepared by a known method. For example, it can be prepared by mixing component (A), component (B), component (C), and component (D), and other components as necessary, in a usual manner.

[0039] In an oral composition, it is preferable that fluoride ions, calcium ions, and phosphate ions form a complex. When the complex is formed, the retention of fluoride ions in the oral cavity is improved, and thereby, the adsorption of fluoride ions to the tooth surface is further improved.

[0040] The formation of the above complex can be confirmed by observing the crystallite size by X-ray crystal structure analysis and the exothermic peak when the crystal water near the phosphate group desorbs at around 450 °C by calorimetry (TG-DTA measurement). That is, when the complex is formed, the crystallite size determined from the diffraction peak attributed to CaF 2 becomes less than 10 nm due to complexation with the phosphate group. Further, the occurrence of the peak of the crystal water indicates that CaF 2 observed by X-ray crystal structure analysis is not a crystal composed only of calcium and fluoride ions, but forms a complex in which phosphate groups interact. Specifically, the formation of the complex is confirmed by the crystallite size being less than 10 nm by the following method (1) and the presence of an exothermic peak at 450 °C being recognized by the following method (2). (1) Crystallite size The sample was measured with an X-ray structure diffractometer (light source Cu:Kα, 40 kV, 20 mA, divergence slit 1 / 2 deg, scattering slit 1 / 2 deg, receiving slit 0.15 mm, scan speed 4.000 ° / min, 2θ = 2.000 to 80.000 °), and the crystallite size was calculated by the following formula (Scherrer's formula) to evaluate the presence or absence of complex formation. L = Kλ / (βcosθ) L: crystallite size, K: coefficient 0.9, β: half-value width, λ: 1.54056 Å, θ: diffraction angle (2) TG-DTA measurement (exothermic peak) Temperature increase rate: 5 °C / min, measurement range: 25 °C to 600 °C

[0041] The method for forming the above complex is not particularly limited. However, when preparing the oral composition, for example, it is preferable to adopt either the step of blending component (B) after blending components (A) and (C), or the step of blending component (A) after blending components (B) and (C). When components (A) and (B) are blended simultaneously, a part of calcium fluoride may be generated, and the formation efficiency of the complex may be inferior.

[0042] Since the oral composition described above contains component (A), component (B), component (C), and component (D), it is excellent in fluorine ion retention and low irritation to the mucosa.

Examples

[0043] Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited by the following description. In the following examples, “%” indicates “% by mass” unless otherwise specified.

[0044] <Raw materials used> Sodium fluoride: manufactured by Stella Chemifa Co., Ltd. Hereinafter, it is also referred to as “NaF”. Calcium chloride: manufactured by Tomita Pharmaceutical Co., Ltd. Hereinafter, it is also referred to as “calcium chloride”. Calcium gluconate: manufactured by Fuso Chemical Industry Co., Ltd. Hereinafter, it is also referred to as “calcium gluconate”. Calcium lactate hydrate: manufactured by Taihei Chemical Industry Co., Ltd., trade name “calcium lactate”. Hereinafter, it is also referred to as “calcium lactate”. Calcium glycerophosphate: manufactured by Iwaki Pharmaceutical Co., Ltd. Hereinafter, it is also referred to as “calcium glycerophosphate”. Calcium pantothenate: manufactured by BASF. Hereinafter, it is also referred to as “calcium pantothenate”. Potassium pyrophosphate: manufactured by Taihei Chemical Industry Co., Ltd. Hereinafter, it is also referred to as “potassium pyrophosphate”. Sodium pyrophosphate: manufactured by Taihei Chemical Industry Co., Ltd., trade name “sodium pyrophosphate (anhydrous)”. Hereinafter, it is also referred to as “sodium pyrophosphate”. Sodium tripolyphosphate: manufactured by Taihei Chemical Industry Co., Ltd. Hereinafter, it is also referred to as “sodium tripolyphosphate”. Sodium lauroyl sarcosinate: Manufactured by Nikko Chemicals Co., Ltd., trade name "NIKKOL Sarcosinate LN". Hereinafter also referred to as "sodium lauroyl sarcosinate". Sodium lauroyl methyl taurate: Manufactured by Nikko Chemicals Co., Ltd., trade name "NIKKOL LMT-P". Hereinafter also referred to as "sodium lauroyl methyl taurate". Sodium tetradecene sulfonate: Manufactured by Lion Specialty Chemicals Co., Ltd., trade name "Lipolan LB-440 (liquid)". Sodium lauroyl glutamate: Manufactured by Asahi Kasei Chemicals Corporation. Sodium cocoyl glutamate: Manufactured by Asahi Kasei Fine Chemicals Corporation. Sodium palmitoyl sarcosinate: Manufactured by Nikko Chemicals Co., Ltd. Sodium cocoyl methyl taurate: Manufactured by NOF Corporation.

[0045] <Examples 1 to 30, Comparative Examples 1 to 6> Toothpaste compositions (gel toothpastes) having the compositions shown in Tables 1 to 4 were prepared by a conventional method. The blanks in the tables indicate that the components are not formulated. "Remainder" of purified water indicates the amount that makes the total amount of the toothpaste composition 100%. The obtained toothpaste compositions were evaluated as follows. The results are also shown in Tables 1 to 4.

[0046] (Evaluation of fluoride ion retention on enamel) A solution obtained by diluting the toothpaste composition 4-fold with purified water was allowed to act on a 6×6 mm square section prepared from bovine tooth enamel for 3 minutes, and immediately washed 3 times with purified water. After drying this section, 120 μL of artificial saliva was treated on the upper surface of the section for 3 minutes, and the concentration (ppm) of the extracted fluoride ions was measured with an ion meter (Orion 1115000 4-Star, manufactured by Thermo Fisher Scientific K.K.), and the average value of N = 3 was determined and evaluated according to the following criteria. [Evaluation criteria] ◎: 0.3 ppm or more. 〇: 0.2 ppm or more and less than 0.3 ppm. △: 0.1 ppm or more and less than 0.2 ppm. ×: Less than 0.1 ppm.

[0047] (Evaluation of low mucosal irritation) The dentifrice composition was used in the normal way, and the irritation of the buccal mucosa after use in the oral cavity was evaluated. Specifically, 10 subjects used the dentifrice composition in the following method, and after 10 minutes, the irritation in the oral cavity was evaluated according to the following 5-level scoring criteria. The average score of 10 subjects was calculated and judged as ◎, ○, △, × according to the following evaluation criteria. [Method of using dentifrice] 1 g of the dentifrice composition was placed on a toothbrush, brushed for 2 minutes, spat out, and then the mouth was rinsed with 50 mL of water. [Scoring criteria] 5 points: No irritation at all. 4 points: Almost no irritation. 3 points: Slightly irritated. 2 points: Feeling irritated. 1 point: Feeling strongly irritated. [Evaluation criteria] ◎: Average score of 4.5 points or more. ○: Average score of 4.0 points or more and less than 4.5 points. △: Average score of 3.0 points or more and less than 4.0 points. ×: Average score of 1.0 points or more and less than 3.0 points.

[0048] (Evaluation of texture) Three tube containers (laminated tubes with a diameter of 26 mm made of linear low-density polyethylene for the innermost layer, manufactured by Dai Nippon Printing Co., Ltd.) were filled with 50 g of the dentifrice composition each and stored at -5°C for 1 month. Under the condition of -5°C, 15 cm × 3 of the dentifrice composition was taken out from the tube container onto the evaluation paper, and after slightly squeezing the dentifrice composition by folding the evaluation paper, the texture of the dentifrice composition when the paper was opened to its original state was evaluated according to the following scoring criteria. The three tubes were evaluated in the same way, and the average score was judged as ◎, ○, △, × according to the following evaluation criteria. [Scoring criteria] 5 points: No wrinkles or grains and there is gloss on the surface. 4 points: Some wrinkles and no gloss. 3 points: There are several wrinkles and grains. 2 points: Wrinkles and grains are uniformly observed. 1 point: Many wrinkles and grains are uniformly observed, and the composition lacks uniformity. [Evaluation Criteria] ◎: Average score of 4.6 or more. ○: Average score of 4.3 or more and less than 4.6. △: Average score of 4.1 or more and less than 4.3. ×: Average score less than 4.1.

[0049]

Table 1

[0050]

Table 2

[0051]

Table 3

[0052]

Table 4

[0053] As shown in the above results, the dentifrice compositions of Examples 1 to 30 were excellent in fluoride ion retention, low mucosal irritation, and texture during low-temperature storage. On the other hand, Comparative Example 1 without the (A) component was inferior in fluoride ion retention and low mucosal irritation. Comparative Example 2 without the (B) component was inferior in fluoride ion retention and low mucosal irritation. Comparative Example 3 without the (C) component was inferior in fluoride ion retention. Comparative Example 4 without the (D) component was inferior in fluoride ion retention and texture during low-temperature storage. Comparative Example 5 containing sodium tripolyphosphate instead of the (C) component was inferior in fluoride ion retention and low mucosal irritation. Comparative Example 6, which contained sodium lauryl sulfate instead of component (D), was inferior in terms of less mucosal irritation and texture retention during low-temperature storage.

[0054] Next, formulation examples are shown. Oral compositions with the following compositions were prepared by conventional methods and evaluated by the same method as above. In all formulation examples, they were excellent in terms of fluoride ion retention and less mucosal irritation. Regarding the dentifrice abrasives, they were also excellent in texture retention during low-temperature storage.

[0055] <Formulation Example 1 Dentifrice Abrasive> Sodium fluoride 0.32% Calcium lactate hydrate 0.2% Sodium pyrophosphate 0.1% Silicic anhydride 10% Sorbitol solution (70%) 40% Propylene glycol 3% Xanthan gum 0.5% Sodium polyacrylate 0.5% Sodium tetradecene sulfonate 0.3% Saccharin sodium 0.2% Fragrance 1% Purified water remainder

[0056] <Formulation Example 2 Dentifrice Abrasive> Sodium fluoride 0.32% Calcium lactate hydrate 0.2% Sodium pyrophosphate 0.1% Silicic anhydride 10% Sorbitol solution (70%) 40% Propylene glycol 3% Xanthan gum 0.5% Sodium polyacrylate 0.5% Sodium lauroyl glutamate 0.3% Saccharin sodium 0.2% Fragrance 1% Purified water remainder

[0057] <Formulation Example 3 Dentifrice Abrasive> Sodium fluoride 0.32% Calcium lactate hydrate 0.2% Sodium pyrophosphate 0.1% Silicic anhydride 10% Sorbitol solution (70%) 40% Propylene glycol 3% Xanthan gum 0.5% Sodium polyacrylate 0.5% Sodium cocooyl glutamate 0.3% Sodium saccharin 0.2% Fragrance 1% Purified water remainder

[0058] <Formulation Example 4 Toothpaste Abrasive> Sodium fluoride 0.32% Calcium lactate hydrate 0.2% Sodium pyrophosphate 0.1% Silicic anhydride 10% Sorbitol solution (70%) 40% Propylene glycol 3% Xanthan gum 0.5% Sodium palmitoyl sarcosinate 0.2% Sodium saccharin 0.2% Fragrance 1% Purified water remainder

[0059] <Formulation Example 5 Toothpaste Abrasive> Sodium fluoride 0.32% Calcium lactate hydrate 0.2% Sodium pyrophosphate 0.1% Silicic anhydride 10% Sorbitol solution (70%) 40% Propylene glycol 3% Xanthan gum 0.5% Sodium cocooyl methyl taurate 0.2% Sodium saccharin 0.2% Fragrance 1% Purified water remainder

[0060] <Formulation Example 6 Mouthwash> Sodium fluoride 0.1% Calcium chloride 0.03% Sodium pyrophosphate 0.1% Glycerin 2% Propylene glycol 3% Sodium lauroyl sarcosinate 0.1% Fragrance 0.3% Purified water remainder

Claims

1. Component (A): Sodium fluoride and, Component (B): A water-soluble calcium salt, and Component (C): At least one selected from the group consisting of pyrophosphoric acid and its alkali metal salts, and Component (D): At least one anionic surfactant selected from the group consisting of N-acyltaurine salts, N-acylamino acid salts, and α-olefin sulfonates, A dental composition containing the same.

2. The dental composition according to claim 1, wherein the component (B) is at least one selected from the group consisting of calcium chloride, calcium glycerophosphate, calcium gluconate, calcium lactate, and calcium pantothenate.

3. The dental composition according to claim 1, wherein the component (C) is at least one selected from the group consisting of pyrophosphoric acid, sodium pyrophosphate, and potassium pyrophosphate.

4. The dental composition according to claim 1, wherein the component (D) is at least one selected from the group consisting of N-acylmethyltaurine salts and N-acylsarcosine salts.

5. The dental composition according to claim 1, wherein the component (D) is at least one selected from the group consisting of sodium N-lauroylmethyltaurine and sodium N-lauroylsarcosine.

6. The molar amount (mmol) of the component (B) per 1 g of the oral composition is B ｍｍоｌ , the mass ratio (% by mass) of the component (D) to the total mass of the oral composition is D ｗｔ％ When it is set as B ｍｍоｌ / D ｗｔ％ The oral composition according to claim 1, wherein the ratio represented by is 0.01 to 2.

7.

7. The dental composition according to any one of claims 1 to 6, which is a dentifrice.

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