Oral composition
The oral composition of kudzu flower, spore-forming lactic acid bacteria, licorice, and black ginger, optionally with oolong tea and cinnamon, addresses the inefficiency of existing dietary therapies by promoting UCP1 gene expression for enhanced fat metabolism and anti-obesity.
Patent Information
- Application Number
- JP2023208929
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2023-12-12
- Publication Date
- 2025-06-24
- Estimated Expiration
- 2043-12-12
AI Technical Summary
Existing dietary therapies for obesity, such as dietary restriction and exercise, are difficult to implement efficiently, and existing fat metabolism improvers like rose hips do not provide sufficient anti-obesity effects.
An oral composition containing kudzu flower, spore-forming lactic acid bacteria, licorice, and black ginger, optionally with oolong tea, green tea extract, and cinnamon, to promote UCP1 gene expression and enhance fat metabolism.
The composition effectively enhances UCP1 gene expression, improving fat burning and providing an excellent anti-obesity effect.
Smart Images

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Abstract
Description
Technical Field
[0001] The present invention relates to an oral composition characterized by containing kudzu flower, spore-forming lactic acid bacteria, licorice, and black ginger.
Background Art
[0002] Due to changes in lifestyle and eating habits, the number of patients with lifestyle-related diseases such as obesity (metabolic syndrome), diabetes, and dyslipidemia, as well as those at risk of developing these diseases, is increasing. Therefore, in order to prevent and improve lifestyle-related diseases, dietary therapies such as dietary restriction and fasting, exercise therapies to promote energy consumption through exercise, and diets combining these have been carried out. In dieting, overeating is prevented by dietary therapy, intake of foods rich in carbohydrates and lipids is avoided, and metabolism is increased by exercise therapy. However, it is difficult to achieve dieting by efficiently implementing both dietary therapy and exercise therapy.
[0003] For the purpose of improving obesity, for example, a fat metabolism improver using rose hips has been developed (Patent Document 1). In addition, rose hips are known to have an effect of activating brown adipocytes and enhancing the expression of uncoupling protein 1 (UCP1), and are being studied as a component for improving obesity. However, the effect on improving obesity is not sufficient, and further study is required.
Prior Art Documents
Patent Documents
[0004]
Patent Document 1
Patent Document 2
Summary of the Invention
Problems to be Solved by the Invention
[0005] Therefore, the present inventors made various studies with the aim of developing a new composition having an excellent dieting effect.
Means for Solving the Problems
[0006] As a result, the present inventors succeeded in developing an oral composition having an excellent dieting effect by blending the flower of kudzu vine, spore-forming lactic acid bacteria, licorice, and black ginger, and thus completed the present invention.
[0007] That is, the present invention is as follows. <1> An oral composition characterized by containing the flower of kudzu vine, spore-forming lactic acid bacteria, licorice, and black ginger. <2> An oral composition characterized by containing the flower of kudzu vine, spore-forming lactic acid bacteria, licorice, black ginger, and at least one selected from oolong tea and green tea extract. <3> An oral composition characterized by containing the flower of kudzu vine, spore-forming lactic acid bacteria, licorice, black ginger, oolong tea, and green tea extract. <4> The oral composition according to <3>, further characterized by containing cinnamon. <5> The oral composition according to any one of <1> to <4>, which is for anti-obesity.
Effects of the Invention
[0008] According to the present invention, by containing the flower of kudzu vine, spore-forming lactic acid bacteria, licorice, and black ginger, a composition excellent in anti-obesity effect (dieting effect) can be provided.
Modes for Carrying Out the Invention
[0009] Hereinafter, the oral composition of the present invention will be described in detail. It should be noted that the present invention is not limited to the following embodiments, and can be changed within the scope that those skilled in the art can conceive, such as other embodiments, additions, modifications, deletions, etc., and as long as the functions and effects of the present invention are achieved in any aspect, it is included in the scope of the present invention.
[0010] <Kudzu flower> The oral composition of the present invention is characterized by containing kudzu flower. Kudzu is a vine-like perennial herbaceous plant of the genus Pueraria in the legume family. As the kudzu flower in the composition of the present invention, those collected at any stage from the bud to the fully opened flower may be used, or those collected at each stage may be mixed and used. There is no particular limitation on the type of kudzu, but examples include Pueraria thomsonii, Pueraria lobata, Pueraria thunbergiana, etc. From the viewpoint of showing an excellent diet effect, Pueraria thomsonii is preferred.
[0011] In the composition of the present invention, processed products of kudzu flower can be used. Examples of the processed product of kudzu flower include extracts and pulverized products.
[0012] When using an extract, examples of the extraction solvent include ethanol, water, polar organic solvents other than ethanol (such as methanol, propanol, butanol, isopropanol, acetone, diethyl ether, etc.), non-polar solvents (hexane, cyclohexane, propane, etc.), or mixed solvents thereof. Among them, ethanol, water, and aqueous ethanol are preferred, and water is particularly preferred. The temperature of the extraction solvent can be appropriately set at room temperature to below the boiling point according to the solvent used. The extract can also be concentrated and / or dried into a powder as needed. As a method for concentrating the extract, for example, appropriate concentration means such as vacuum concentration, reverse osmosis membrane (RO membrane) concentration, and freeze concentration can be adopted. As a method for drying and pulverizing the extract into a powder, commonly used drying methods can be used, for example, drying and pulverizing into a powder using drying methods such as spray drying, freeze drying, and vacuum drying. When drying and pulverizing into a powder, it can also be dried together with an excipient such as dextrin.
[0013] When using a pulverized product, for example, a dried pulverized powder obtained by drying and pulverizing kudzu flower can be mentioned.
[0014] In the present invention, from the viewpoint of enjoying the diet effect, an extract is preferable, and a water extract is particularly preferable.
[0015] The content of the flower of kudzu vine in the oral composition of the present invention is not particularly limited. For example, in the solid content, 1% by mass or more is preferable, more preferably 3% by mass or more, and particularly preferably 5% by mass or more from the viewpoint of excellent stability and the ability to be orally ingested easily and for a long period of time. Also, 60% by mass or less is preferable, 50% by mass or less is more preferable, and 40% by mass or less is particularly preferable. Note that the solid content in this specification is the amount obtained by removing moisture from the composition.
[0016] <Sporogenous lactic acid bacteria> The oral composition of the present invention is characterized by containing sporogenous lactic acid bacteria. Sporogenous lactic acid bacteria are lactic acid bacteria that form spores and are characterized by being resistant to drying, heat, and acid. Examples of sporogenous lactic acid bacteria include bacteria belonging to the genus Bacillus. In the present invention, from the viewpoint of exhibiting an excellent diet effect, Bacillus coagulans (also referred to as Weizmannia coagulans) is particularly preferable. In the present invention, commercially available products of sporogenous lactic acid bacteria that are usually available as food raw materials can be used.
[0017] The content of sporogenous lactic acid bacteria in the oral composition of the present invention is not particularly limited. For example, in the solid content, 0.1% by mass or more is preferable, more preferably 0.5% by mass or more, and particularly preferably 1% by mass or more from the viewpoint of excellent stability and the ability to be orally ingested easily and for a long period of time. Also, 50% by mass or less is preferable, 40% by mass or less is more preferable, and 30% by mass or less is particularly preferable.
[0018] <Licorice> The oral composition of the present invention is characterized by containing licorice (Glycyrrhiza glabra). Licorice is a plant of the genus Glycyrrhiza in the legume family. As licorice in the composition of the present invention, roots and / or stolons can be used.
[0019] In the composition of the present invention, licorice can be used in the form of processed products. Examples of processed licorice products include extracts and pulverized products.
[0020] When using an extract, examples of the extraction solvent include ethanol, water, polar organic solvents other than ethanol (such as methanol, propanol, butanol, isopropanol, acetone, diethyl ether, etc.), non-polar solvents (hexane, cyclohexane, propane, etc.), or a mixed solvent thereof. The temperature of the extraction solvent can be appropriately set according to the solvent used, within the range from room temperature to below the boiling point. The extract can also be concentrated and / or dried into a powder as needed. As a method for concentrating the extract, for example, appropriate concentration means such as vacuum concentration, reverse osmosis membrane (RO membrane) concentration, and freeze concentration can be adopted. As a method for drying the extract into a powder, commonly used drying methods can be used. For example, it can be dried into a powder using drying methods such as spray drying, freeze drying, and vacuum drying. When drying into a powder, it can also be dried together with an excipient such as dextrin.
[0021] When using a pulverized product, for example, it includes a dry pulverized powder obtained by drying and pulverizing the roots and / or stolons of licorice.
[0022] In the present invention, from the perspective of enjoying the diet effect, the pulverized product of licorice is preferred, and the pulverized powder is particularly preferred.
[0023] The content of licorice in the oral composition of the present invention is not particularly limited. For example, in the solid content, it is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, and particularly preferably 0.005% by mass or more from the viewpoints of excellent stability, easy and long-term oral intake. Also, it is preferably 30% by mass or less, more preferably 20% by mass or less, and particularly preferably 15% by mass or less.
[0024] <Black Ginger> The oral composition of the present invention is characterized by containing black ginger. Black ginger (Kaempferia parviflora) is a plant of the genus Boesenbergia in the Zingiberaceae family, known to grow wild in Southeast Asia and other regions. As the black ginger in the composition of the present invention, roots and stems (rhizomes) can be used.
[0025] In the composition of the present invention, processed products of black ginger can be used. Examples of processed products of black ginger include extracts and pulverized products.
[0026] When using an extract, examples of the extraction solvent include ethanol, water, polar organic solvents other than ethanol (such as methanol, propanol, butanol, isopropanol, acetone, diethyl ether, etc.), non-polar solvents (hexane, cyclohexane, propane, etc.), or mixed solvents thereof. Among these, ethanol, water, and hydrous ethanol are preferred, and hydrous ethanol is particularly preferred. The temperature of the extraction solvent can be appropriately set at room temperature to below the boiling point according to the solvent used. The extract can also be concentrated and / or dried into a powder as needed. As a method for concentrating the extract, for example, appropriate concentration means such as vacuum concentration, reverse osmosis membrane (RO membrane) concentration, and freeze concentration can be adopted. As a method for drying the extract into a powder, commonly used drying methods can be used. For example, it can be dried into a powder using drying methods such as spray drying, freeze drying, and vacuum drying. When drying into a powder, it can also be dried together with an excipient such as dextrin.
[0027] When using a pulverized product, for example, a dried pulverized powder obtained by drying and pulverizing the rhizome of black ginger can be mentioned.
[0028] In the present invention, from the viewpoint of enjoying the diet effect, an extract is preferred, and a hydrous ethanol extract is particularly preferred.
[0029] The content of black ginger in the oral composition of the present invention is not particularly limited. For example, in the solid content, it is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, and particularly preferably 0.005% by mass or more from the viewpoint of excellent stability and enabling easy and long-term oral intake. Also, it is preferably 30% by mass or less, more preferably 20% by mass or less, and particularly preferably 15% by mass or less.
[0030] <Oolong tea> The oral composition of the present invention preferably contains oolong tea in addition to kudzu flower, spore-forming lactic acid bacteria, licorice, and black ginger.
[0031] In the composition of the present invention, processed products of oolong tea can be used. Examples of oolong tea processed products include extracts and pulverized products. Oolong tea, also called blue tea, is a tea made by stopping the fermentation of the leaves of Camellia sinensis halfway and semi-fermenting them.
[0032] In the composition of the present invention, processed products of oolong tea can be used. Examples of oolong tea processed products include extracts and pulverized products.
[0033] When using an extract, examples of the extraction solvent include ethanol, water, polar organic solvents other than ethanol (such as methanol, propanol, butanol, isopropanol, acetone, diethyl ether, etc.), non-polar solvents (hexane, cyclohexane, propane, etc.), or a mixed solvent thereof. Among them, alcohols such as ethanol, water, and hydrous alcohol are preferred, and hydrous alcohol is particularly preferred. The temperature of the extraction solvent can be appropriately set from room temperature to below the boiling point according to the solvent used. The extract can also be concentrated and / or dried into a powder as needed. As a method for concentrating the extract, for example, appropriate concentration means such as vacuum concentration, reverse osmosis membrane (RO membrane) concentration, and freeze concentration can be adopted. As a method for drying and powdering the extract, commonly used drying methods can be used, and for example, it can be dried and powdered using drying methods such as spray drying, freeze drying, and vacuum drying. When drying and powdering, it can also be dried together with an excipient such as dextrin.
[0034] When using a pulverized product, for example, a dried pulverized powder obtained by drying and pulverizing oolong tea leaves can be mentioned.
[0035] In the present invention, from the viewpoint of enjoying the diet effect, an extract is preferred, and a hydrous alcohol extract is particularly preferred.
[0036] The content of oolong tea in the oral composition of the present invention is not particularly limited. For example, in the solid content, 0.0001% by mass or more is preferred, more preferably 0.001% by mass or more, and particularly preferably 0.005% by mass or more from the viewpoints of excellent stability, easy and long-term oral intake. Also, 30% by mass or less is preferred, 20% by mass or less is more preferred, and 15% by mass or less is particularly preferred.
[0037] <Chimpi> The oral composition of the present invention preferably contains Chimpi in addition to the flowers of kudzu vine, spore-forming lactic acid bacteria, licorice, and black ginger. Chimpi (dried tangerine peel) is the dried peel of tangerine. Examples of the type of tangerine include Unshu tangerine and mandarin orange.
[0038] In the composition of the present invention, chinpi can be used in the processed product. Examples of the chinpi processed product include an extract and a pulverized product.
[0039] When using an extract, examples of the extraction solvent include ethanol, water, polar organic solvents other than ethanol (e.g., methanol, propanol, butanol, isopropanol, acetone, diethyl ether, etc.), nonpolar solvents (hexane, cyclohexane, propane, etc.), or a mixed solvent thereof. The temperature of the extraction solvent can be appropriately set from room temperature to below the boiling point according to the solvent used. The extract can also be concentrated and / or dried into a powder as necessary. As a method for concentrating the extract, for example, appropriate concentration means such as vacuum concentration, reverse osmosis membrane (RO membrane) concentration, and freeze concentration can be employed. As a method for drying the extract into a powder, a commonly used drying method can be used, and for example, it can be dried into a powder using a drying method such as spray drying, freeze drying, or vacuum drying. When drying into a powder, it can also be dried together with an excipient such as dextrin.
[0040] When using a pulverized product, for example, a dry pulverized powder obtained by drying and pulverizing chinpi can be mentioned.
[0041] In the present invention, from the viewpoint of enjoying the diet effect, the pulverized product is preferable for chinpi, and the pulverized powder is particularly preferable.
[0042] The content of chinpi in the oral composition of the present invention is not particularly limited. For example, in the solid content, it is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, and particularly preferably 0.005% by mass or more from the viewpoints of excellent stability, easy and long-term oral intake. Also, it is preferably 30% by mass or less, more preferably 20% by mass or less, and particularly preferably 15% by mass or less.
[0043] <Cinnamon> The oral composition of the present invention preferably contains cinnamon in addition to kudzu flowers, spore-forming lactic acid bacteria, licorice, black ginger, oolong tea, and chinpi. Cinnamon is a spice obtained from the inner bark of trees of the genus Cinnamomum, and is also called cinnamon, nikkei, and cassia bark.
[0044] In the composition of the present invention, processed cinnamon products can be used. Examples of cinnamon processed products include extracts and pulverized products.
[0045] When using an extract, examples of the extraction solvent include ethanol, water, polar organic solvents other than ethanol (such as methanol, propanol, butanol, isopropanol, acetone, diethyl ether, etc.), non-polar solvents (hexane, cyclohexane, propane, etc.), or mixed solvents thereof. The temperature of the extraction solvent can be appropriately set from room temperature to below the boiling point according to the solvent used. The extract can also be concentrated and / or dried into a powder as needed. As a method for concentrating the extract, for example, appropriate concentration means such as vacuum concentration, reverse osmosis membrane (RO membrane) concentration, and freeze concentration can be employed. As a method for drying the extract into a powder, commonly used drying methods can be used. For example, it can be dried into a powder using drying methods such as spray drying, freeze drying, and vacuum drying. When drying into a powder, it can also be dried together with an excipient such as dextrin.
[0046] When using a pulverized product, for example, a dry pulverized powder obtained by drying and pulverizing cinnamon can be mentioned.
[0047] In the present invention, from the viewpoint of enjoying the diet effect, the pulverized product of cinnamon is preferred, and the pulverized powder is particularly preferred.
[0048] The content of cinnamon in the oral composition of the present invention is not particularly limited. For example, in the solid content, it is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, and particularly preferably 0.005% by mass or more from the viewpoint of excellent stability and enabling easy and long-term oral intake. Also, it is preferably 30% by mass or less, more preferably 20% by mass or less, and particularly preferably 15% by mass or less.
[0049] <Other components> In the oral composition of the present invention, other components can be blended as necessary in addition to the above components. Examples of other components include excipients, lubricants, dietary fibers such as water-soluble dietary fiber and insoluble dietary fiber, proteins, various vitamins and minerals, microorganisms such as algae and yeast. Furthermore, as necessary, sweeteners, acidulants, nutritional supplements, stabilizers, binders, brighteners, thickeners, colorants, diluents, emulsifiers, food additives, seasonings, etc. that are usually used in the food field can be mentioned. The content of these other components can be appropriately selected according to the form of the composition of the present invention.
[0050] <Composition for diet> The oral composition of the present invention can be used in various forms for the purpose of obtaining a diet effect by containing kudzu flower, spore-forming lactic acid bacteria, licorice, and black ginger.
[0051] The oral composition of the present invention can be used as so-called health foods such as general foods, for example, pharmaceuticals (including quasi-drugs), foods for specified health uses, foods with nutritional functions, functional foods with a recognized function display from a prescribed agency, etc.
[0052] That is, since the oral composition of the present invention has an activity of promoting UCP1 gene expression and is effective in anti-obesity, it can be used as a composition for anti-obesity. Such a composition for anti-obesity contains the main components of the present invention (flower of kudzu vine, spore-forming lactic acid bacteria, licorice, black ginger), and is not particularly limited as long as it can be distinguished from other products as a product in terms of exerting an anti-obesity function. For example, those that display the anti-obesity function on any of the main body, packaging, instruction manual, and promotional materials (advertising media) of the product according to the present invention are included in the scope of the present invention. Specifically, for example, those displaying "metabolism promotion", "for those concerned about body fat", "for those with a tendency to obesity", "for those concerned about body weight (BMI)", "reducing body weight and abdominal fat (visceral fat and subcutaneous fat)", "reducing waist circumference", "supporting diet", "for those concerned about their figure", etc. can be exemplified.
[0053] In addition, the oral composition of the present invention may be one in which the main components of the present invention are indicated as active ingredients, but is not limited to those in which the main components of the present invention are indicated as active ingredients. For example, it may be one in which no active ingredient is indicated. Also, even general foods that are manufactured and sold with suggestions of functions and uses are included in the scope of the present invention. For example, foods sold with testimonials on a homepage or the like that mention functions and uses as personal impressions of the consumers who have ingested them can be cited.
[0054] The oral composition of the present invention is not particularly limited as long as it is in a form suitable for oral use, and may be in a fluid form such as liquid, syrup, paste, gel, jelly, cream, emulsion, spray, mousse, lotion, etc. Solid forms include powder, granule, pellet, tablet, chewable, capsule, soft capsule, etc., and powder, granule, pellet, tablet, chewable are preferred, and powder, granule, pellet, tablet, chewable are particularly preferred from the viewpoint of ease of ingestion.
[0055] The daily dosage of the oral composition of the present invention is not particularly limited and can be appropriately set according to the usage mode, the content of use by the user, etc. For example, the daily dosage of the oral composition of the present invention, based on the weight of the user, in terms of solid content, is preferably 0.01 to 1000 mg / kg, more preferably 0.1 to 500 mg / kg, and from the viewpoint of exerting the effect of the oral composition of the present invention, even more preferably 0.5 to 100 mg / kg.
[0056] Similarly, the single dosage of the oral composition of the present invention is not particularly limited. For example, the single dosage of the oral composition of the present invention, based on the weight of the user, in terms of solid content, is preferably 0.001 to 2000 mg / kg, more preferably 0.01 to 1000 mg / kg, and from the viewpoint of exerting the effect of the oral composition of the present invention, even more preferably 0.1 to 100 mg / kg.
[0057] Also, the daily dosage of the oral composition of the present invention is not particularly limited. For example, in terms of solid content, it is preferably 0.001 to 20 g, more preferably 0.01 to 10 g, and from the viewpoint of exerting the effect of the oral composition of the present invention, particularly preferably 0.1 to 5 g.
[0058] The single dosage of the oral composition of the present invention is not particularly limited. For example, in terms of solid content, it is preferably 0.0001 to 20 g, more preferably 0.001 to 10 g, and from the viewpoint of exerting the effect of the oral composition of the present invention, particularly preferably 0.01 to 5 g.
[0059] The packaging form of the oral composition of the present invention is not particularly limited and can be appropriately selected according to the dosage form, etc. For example, blister packs such as PTP; strip packaging; heat sealing; aluminum pouches; film packaging using plastics, synthetic resins, etc.; glass containers such as vials; plastic containers such as ampoules, etc.
Examples
[0060] Hereinafter, the present invention will be described in more detail based on examples, but the present invention is not limited thereto.
[0061] <Test 1 Evaluation of UCP1 gene expression level> Using brown adipocytes derived from rat interscapular brown adipose tissue, the UCP1 gene expression level was evaluated. Brown adipocytes derived from interscapular brown adipose tissue are frequently used when examining the function of brown adipocytes related to fat burning. If the UCP1 gene expression level is high, the fat burning effect is high and body fat decreases, so it is considered that an anti-obesity effect can be obtained.
[0062] [Test substance] · Kudzu flower: The dried powder of the water extract of kudzu flower was used. · Spore-forming lactic acid bacteria: Weizmannia coagulans was used. · Licorice: The ground powder of licorice root and stolons was used. · Black ginger: The dried powder of the hydrous ethanol extract of the rhizome of black ginger was used. · Oolong tea: The dried powder of the hydrous alcohol extract of oolong tea was used. · Chinpi: The ground powder of tangerine peel was used. · Cinnamon: The ground powder of cinnamon was used. · Rose hip: The ground powder of rose hip was used.
[0063] Using a growth medium for growth, a differentiation induction medium for differentiation induction, and an adipocyte maintenance medium for differentiation maintenance, the following procedure was carried out. (1) The differentiation maintenance medium containing the test substance was prepared as follows. The test substance was dissolved and diluted in the differentiation maintenance medium and filter sterilized. The test substances were mixed so as to have the ratios shown in the following table and prepared to be 1 μg / mL. (2) Rat brown adipose progenitor cells (manufactured by Cosmo Bio) were seeded in a collagen-coated 96-well plate at 1.0×10 4 cells / well using the growth medium, and cultured in a 37°C, 5 (vol / vol)% CO2 incubator until the cell density reached about 90%. (3) After removing the medium, 100 μL / well of the differentiation induction medium was added, and the cells were cultured in an incubator at 37 °C and 5 (vol / vol)% CO2 for 72 hours to induce differentiation into brown adipocytes. (4) After removing the medium, 100 μL / well of the differentiation maintenance medium was added, and the cells were cultured in an incubator at 37 °C and 5 (vol / vol)% CO2 for 72 hours. (5) After removing the medium, 100 μL / well of the differentiation maintenance medium was added, and the cells were cultured in an incubator at 37 °C and 5 (vol / vol)% CO2 for an additional 24 hours. (6) After removing the medium from each well, 100 μL / well of the differentiation maintenance medium containing the test substance was added, and the cells were cultured in an incubator at 37 °C and 5 (vol / vol)% CO2 for 6 hours. (7) RNA was recovered using the CellAmp Direct RNA Prep Kit for RT-PCR (Real Time) (manufactured by TaKaRa). (8) Using the obtained RNA, real-time PCR was performed using the One Step TB Green (registered trademark) PrimeScript RT-PCR Kit II (Perfect Real Time) (manufactured by TaKaRa). The gene expression level of UCP1 was measured using the primers for UCP1 (manufactured by QIAGEN, product name: Rn_Ucp1_1_SG QuantiTect Primer Assay (QT00183967)). Also, as an endogenous control, the gene expression level of GAPDH was measured using the primers for GAPDH (manufactured by QIAGEN, product name: Rn_Gapd_1_SG QuantiTect Primer Assay (QT00199633)). The relative value was calculated with the value of the control without the test substance added set to 100 for the gene expression level of UCP1. The results are shown in Table 1.
[0064]
Table 1
[0065] As can be seen from Table 1, in Examples 1 to 5 in which the main components of the present invention (flower of kudzu vine, spore-forming lactic acid bacteria, licorice, black ginger) were formulated, higher UCP1 gene expression was observed compared to the case where each component was used alone (Comparative Examples 1 to 4). Also, higher UCP1 gene expression was observed compared to the case where rose hip, which is known to have an anti-obesity effect and a UCP1 gene expression promoting effect, was combined and formulated (Comparative Examples 6 to 8). In particular, when oolong tea and green tea were formulated in addition to the flower of kudzu vine, spore-forming lactic acid bacteria, licorice, and black ginger (Examples 2 to 4), and when cinnamon was further formulated (Example 5), UCP1 gene expression was improved in all treatment groups compared to the treatment group without addition. From the above, it is clear that the oral composition of the present invention containing the flower of kudzu vine, spore-forming lactic acid bacteria, licorice, and black ginger has an excellent UCP1 gene expression promoting action, and thus it is considered that the fat burning action is improved and an excellent anti-obesity effect is exhibited due to the reduction of body fat.
[0066] <Production Example> According to the composition described in Table 2 below, after mixing each raw material, tableting was performed using a rotary tableting machine to produce tablets (300 mg per tablet). Since the oral composition obtained in the following Production Example contains the flower of kudzu vine, spore-forming lactic acid bacteria, licorice, and black ginger, an excellent dieting effect can be enjoyed by ingesting 3 to 5 tablets once a day.
[0067]
Table 2
Industrial Applicability
[0068] Since the oral composition of the present invention contains the flower of kudzu vine, spore-forming lactic acid bacteria, licorice, and black ginger, it can provide an oral composition excellent in dieting effect, and thus has high industrial applicability.
Claims
1. An oral composition characterized by containing kudzu flower, spore-forming lactic acid bacteria, licorice, and black ginger.
2. An oral composition characterized by containing kudzu flower, spore-forming lactic acid bacteria, licorice, black ginger, and at least one selected from oolong tea and green tea.
3. An oral composition characterized by containing kudzu flower, spore-forming lactic acid bacteria, licorice, black ginger, oolong tea, and green tea.
4. The oral composition according to claim 3, further characterized by containing cinnamon.
Citation Information
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