Dose sensation evaluation method, dose sensation evaluation device, and program

Abstract

To provide a dose sensation evaluation method for a pharmaceutical preparation that can be quantitatively evaluated.SOLUTION: A dose sensation evaluation method of a pharmaceutical preparation includes attaching a part of an electromyograph to a human body and acquiring measurement data measured when dosing a pharmaceutical preparation using the attached electromyograph, and generating dose sensation evaluation information when dosing the pharmaceutical preparation on the basis of the measurement data. In the dose sensation evaluation method, the electromyograph may be attached to either the suprahyoid muscles or the infrahyoid muscles of the human body.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to a new evaluation method for pharmaceutical preparations. More specifically, it relates to a novel measurement method, measurement device, and program for evaluating the feeling of taking a pharmaceutical preparation based on the amount of muscle activity when taking the pharmaceutical preparation.

Background Art

[0002] In recent years, when evaluating the feeling of taking a pharmaceutical preparation, in addition to the subjective evaluation by the subject (Non-Patent Documents 1 to 4), methods for objectively evaluating the swallowing ability and the feeling of taking the preparation using equipment and the like are known (Non-Patent Documents 5 to 7).

Prior Art Documents

Non-Patent Documents

[0003]

Non-Patent Document 1

Non-Patent Document 2

Non-Patent Document 3

Non-Patent Document 4

Non-Patent Document 5

Non-Patent Document 6

Non-Patent Document 7

Summary of the Invention

Problems to be Solved by the Invention

[0004] The currently widely used subjective evaluation by the subject is difficult to maintain objectivity and reproducibility. Therefore, an objective method using equipment or the like is desired, but no established method is yet known.

[0005]

Means for Solving the Problems

[0006] According to an embodiment of the present invention, a part of an electromyograph is attached to the human body, measurement data measured when taking a pharmaceutical preparation is acquired using the attached electromyograph, and ingestion feeling evaluation information when taking the pharmaceutical preparation is generated based on the measurement data, and an ingestion feeling evaluation method for a pharmaceutical preparation is provided.

[0007]

[0008] ​​In the above method for evaluating the taste of administration, after obtaining the measurement data, the first data included in the measurement data is processed by taking the root mean square to generate second data. From the second data, points exceeding the value obtained by adding twice the standard deviation to the average value of the baseline when the pharmaceutical preparation corresponding to the second data is not being taken are adopted to generate third data. Based on the third data, the taste of administration evaluation information may be generated.

[0009] In the above method for evaluating the taste of administration, based on the maximum value of the potential in the third data, the taste of administration evaluation information may be generated.

[0010] In the above method for evaluating the taste of administration, based on the area value generated from the third data, the taste of administration evaluation information may be generated.

[0011] In the above method for evaluating the taste of administration, when the taste of administration evaluation information satisfies a predetermined condition, it may be determined that the taste of administration is good.

[0012] In the above method for evaluating the taste of administration, the result of determining the taste of administration when the subject takes the pharmaceutical preparation may be notified.

[0013] In the above method for evaluating the taste of administration, the pharmaceutical preparation may be any one of a capsule, a tablet, a granule, and a powder.

[0014] According to an embodiment of the present invention, a program for causing a computer to execute the above method for evaluating the taste of administration is provided.

[0015] According to an embodiment of the present invention, a taste of administration evaluation device for a pharmaceutical preparation including a control unit is provided, which acquires measurement data measured when taking a pharmaceutical preparation using an electromyograph worn on a human body, and generates taste of administration evaluation information when taking the pharmaceutical preparation based on the measurement data.

[0016] In the above-mentioned taste evaluation device, when measuring the measurement data, the electromyograph may be attached to either the suprahyoid muscle group or the infrahyoid muscle group of the human body.

[0017] In the above-mentioned taste evaluation device, after acquiring the measurement data, the control unit performs root mean square processing on the first data included in the measurement data to generate second data, and from the second data, a value obtained by adding twice the standard deviation to the average value of the baseline when the pharmaceutical preparation corresponding to the second data is not being taken is used as a threshold. Points exceeding this threshold are adopted to generate third data, and based on the third data, the taste evaluation information may be generated.

[0018] In the above-mentioned taste evaluation device, the control unit may generate the taste evaluation information based on the maximum value of the potential in the third data.

[0019] In the above-mentioned taste evaluation device, the control unit may generate the taste evaluation information based on the area value generated from the third data.

[0020] In the above-mentioned taste evaluation device, when the taste evaluation information satisfies a predetermined condition, the control unit may determine that the taste is good.

[0021] In the above-mentioned taste evaluation device, the control unit may notify the result of determining the taste when the subject takes the pharmaceutical preparation.

[0022] In the above-mentioned taste evaluation device, the pharmaceutical preparation may be any one of a capsule, a tablet, a granule, and a powder.

Advantages of the Invention

[0023] According to the present invention, it is possible to provide a method for evaluating the taste of a pharmaceutical preparation that can be quantitatively evaluated.

Brief Description of the Drawings

[0024]

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Embodiments for Carrying Out the Invention

[0025] The following embodiments are examples of embodiments of the present invention, and the present invention is not limited to these embodiments. In the drawings referred to in this embodiment, the same parts or parts having the same functions are denoted by the same reference numerals or similar reference numerals, and the repeated description thereof may be omitted.

[0026] A feeling-of-taking evaluation system according to an embodiment of the present invention will be described in detail with reference to the drawings.

[0027] (1-1. Hardware Configuration of Feeling-of-Taking Evaluation System) FIG. 1 shows the hardware configuration of the feeling-of-taking evaluation system 1. As shown in FIG. 1, the feeling-of-taking evaluation system 1 includes a feeling-of-taking evaluation device 10 and an electromyograph 30. The feeling-of-taking evaluation device 10 can also function as a database and an application server for feeling-of-taking evaluation. The electromyograph 30 is a device that is worn on the human body and measures the potential changes that occur when taking a pharmaceutical preparation. In this embodiment, for the sake of convenience of explanation, the case of using one electromyograph 30 is shown, but a plurality of electromyographs 30 may be used as appropriate.

[0028] According to the feeling-of-taking evaluation system 1, the electromyograph 30 transmits measurement data (data indicating potential fluctuations) measured when taking a pharmaceutical preparation to the feeling-of-taking evaluation device 10 via the network NW. The feeling-of-taking evaluation device 10 analyzes the measurement data. Then, the feeling-of-taking evaluation device 10 generates feeling-of-taking evaluation information from the analysis result and makes a determination of the feeling of taking based on the feeling-of-taking evaluation information (result). Hereinafter, the configuration of the feeling-of-taking evaluation system for realizing such processing will be described.

[0029] The feeling-of-taking evaluation device 10 has a control unit 11, a storage unit 12, a communication unit 13, a display unit 14, and an operation unit 15. The feeling-of-taking evaluation device 10 may be used as a server. In this case, it may be either an on-premises or a cloud server.

[0030] The control unit 11 is a computer, which uses a CPU (Central Processing Unit), an ASIC (Application Specific Integrated Circuit), an FPGA (Field Programable Gate Array), or other arithmetic processing circuits to control the processing based on the instructions defined in the software (program) for the wearing feeling evaluation control described later. In addition, a user interface for executing the wearing feeling evaluation control program may be provided on the display unit 14 according to the instructions from the control unit 11.

[0031] In the storage unit 12, in addition to a semiconductor memory such as an SSD (Solid State Drive), a magnetic recording medium (magnetic tape, magnetic disk, etc.), an optical recording medium, a magneto-optical recording medium, and a storage-capable element as a storage medium are used. The storage unit 12 has a function as a database for storing the wearing feeling evaluation control information used in the wearing feeling evaluation control program. The storage unit 12 may be provided in a device different from the wearing feeling evaluation device 10 as appropriate and function as a database.

[0032] The communication unit 13 has a transceiver and performs transmission and reception of measurement data with the electromyograph 30 via the network NW. The communication between the communication unit 13 and the electromyograph 30 is performed by wire or wirelessly.

[0033] The operation unit 15 includes a controller, buttons, or switches. When operations such as moving up, down, left, or right, pressing, or rotating are performed on the operation unit 15, information based on the operations is transmitted to the control unit 11. If it is a display device (touch panel) having a touch sensor, the display unit 14 and the operation unit 15 may be arranged in the same place.

[0034] Although not shown, the wearing feeling evaluation device 10 may have an audio output unit (buzzer) and an illumination unit (light).

[0035] The electromyograph 30 includes a control unit 31, a memory unit 32, a communication unit 33, an operation unit 34, and a measurement unit 35. The electromyograph 30 is used by being attached to either the suprahyoid muscle group or the infrahyoid muscle group of the human body.

[0036] The control unit 31 is a computer and includes a CPU, an ASIC, an FPGA, or other arithmetic processing circuits. The control unit 31 causes a program related to the evaluation of the feeling of taking medicine stored in the memory unit 32 such as a memory to be executed based on the operation of the operation unit 34, and instructs the execution of processing related to the program for controlling the evaluation of the feeling of taking medicine stored in the memory unit 12 of the device 10 for evaluating the feeling of taking medicine.

[0037] The communication unit 33 has a function of transmitting and receiving data to and from the device 10 for evaluating the feeling of taking medicine. For example, a LAN transceiver (e.g., a Wi-Fi transceiver) is used for the communication unit 33. Note that the transceiver is not limited to a LAN transceiver, and a transceiver for mobile terminal communication (e.g., LTE communication) may be provided, or a transceiver for short-range wireless communication may be provided. The electromyograph 30 is connected to the device 10 for evaluating the feeling of taking medicine via the network NW.

[0038] The operation unit 34 includes a controller, buttons, or switches. When operations such as moving up, down, left, or right, pressing, or rotating are performed on the operation unit 34, information based on the operation is transmitted to the control unit 31.

[0039] The measurement unit 35 includes electrodes for attaching to the human body. The electrodes have any form (shape) such as needle electrodes, wire electrodes, or surface electrodes.

[0040] (1-2. Software Configuration of the System for Evaluating the Feeling of Taking Medicine) FIG. 2 is a diagram showing the software configuration of the system 1 for evaluating the feeling of taking medicine. The control unit 11 of the device 10 for evaluating the feeling of taking medicine includes an acquisition unit 11a, a generation unit 11b, a determination unit 11c, and a notification unit 11d.

[0041] The acquisition unit 11a has a function of acquiring measurement data from the electromyograph 30. Note that the acquisition unit 11a may acquire measurement data stored in advance in the feeling-of-wearing database (DB) 12a of the storage unit 12.

[0042] The generation unit 11b has a function of generating various types of information based on the measurement data acquired by the acquisition unit 11a. In this example, the generation unit 11b generates feeling-of-wearing evaluation information.

[0043] The determination unit 11c has a function of determining whether the acquired information satisfies a predetermined condition. In this example, the determination unit 11c determines whether the generated feeling-of-wearing evaluation information exceeds a threshold value.

[0044] The notification unit 11d has a function of notifying the outside of the determination result of the feeling of wearing. In this example, the determination result may be displayed on the display unit 14 of the feeling-of-wearing evaluation device 10, transmitted to an external device, or output as sound or light.

[0045] The electromyograph 30 includes a measurement unit 310 and a transmission unit 320. The measurement unit 310 has a function of measuring the fluctuation of the potential at the attached site. The transmission unit 320 has a function of transmitting the measured potential (measurement data) to the feeling-of-wearing evaluation device 10.

[0046] (1-3. Feeling-of-wearing evaluation method) Next, a feeling-of-wearing evaluation method realized in the feeling-of-wearing evaluation system according to the first embodiment of the present invention will be described. FIGS. 3 to 5 are flowcharts showing the feeling-of-wearing evaluation method of the feeling-of-wearing evaluation system 1 in the present embodiment.

[0047] First, the electromyograph 30 is attached to the human body (step S101). The electromyograph 30 is used by being attached to either the suprahyoid muscle group or the infrahyoid muscle group of the human body.

[0048] When evaluating the feeling of taking a medicine using the electromyograph 30, start recording in accordance with the signal. Next, after starting the recording, give a signal to take the medicine 5 seconds later, and let the person (subject) take the tablet. Continue the measurement for another 5 seconds after taking the medicine. This series of data is taken as measurement data (step S103). The frequency band adopted in the measurement is 50 to 450 Hz. The measurement data measured by the electromyograph 30 is transmitted to the feeling-of-taking-medicine evaluation device 10 by wire or wirelessly (step S105).

[0049] Next, the control unit 11 of the feeling-of-taking-medicine evaluation device 10 acquires the transmitted measurement data (step S107). The acquired measurement data is stored (stored) in the feeling-of-taking-medicine evaluation DB 12a.

[0050] Next, the feeling-of-taking-medicine evaluation device 10 generates feeling-of-taking-medicine evaluation information based on the measurement data (step S109). The method for generating the feeling-of-taking-medicine evaluation information will be specifically described below.

[0051] (Generation of feeling-of-taking-medicine evaluation information) FIG. 4 is a flowchart for generating the feeling-of-taking-medicine evaluation information. First, the feeling-of-taking-medicine evaluation device 10 acquires the measurement data (step S1091). At this time, the measurement data includes RAW data (first data) composed of potential values at each time as shown in FIG. 6. The RAW data includes positive potential values and negative potential values.

[0052] Next, the feeling-of-taking-medicine evaluation device 10 performs root mean square (RMS) processing on the RAW data (generates second data) (step S1092). As a result, as shown in FIG. 7, the second data shows positive potential values.

[0053] Next, for the data (second data) processed by the root mean square operation, as shown in FIG. 8, the dosing feeling evaluation apparatus 10 sets a baseline (in this case, 0 to 3000 sec), and a value obtained by adding twice the standard deviation (Standard Deviation, S.D.) to the average value of the baseline (also referred to as the "base value") from the second data (average value + 2S.D.) is used as the muscle activity evaluation point (corresponding to the muscle activity evaluation period of 3000 to 9000 sec), and the numerical value is used as the third data (step S1093). As a result, as shown in FIG. 9, the numerical values other than during dosing become "0".

[0054] Next, using the third data, a maximum value and a total area value are generated. Values (ratios) obtained by dividing these maximum value and total area value by the data (maximum value, total area value) when drinking water are calculated (step S1094). These are used as the dosing feeling evaluation information.

[0055] Returning to FIG. 3 for explanation. Next, the dosing feeling evaluation apparatus 10 determines the dosing feeling using the dosing feeling evaluation information (step S111). FIG. 5 is a flowchart of the determination process. First, the dosing feeling evaluation apparatus 10 determines the dosing feeling based on whether the dosing feeling evaluation information satisfies a predetermined condition (step S1111). The predetermined condition is that the maximum value ratio (or total area ratio) among the dosing feeling evaluation information is less than a preset threshold value. When the maximum value ratio (or total area ratio) among the dosing feeling evaluation information satisfies the predetermined condition (step S1112; Yes), it is determined that the dosing feeling is good (step S1113). When the maximum value ratio (or total area ratio) among the dosing feeling evaluation information does not satisfy the predetermined condition (step S1112; No), it is determined that the dosing feeling is not good (step S1114).

[0056] The determination result of the taste of taking the medicine may be notified to the outside. In this example, the determination result may be displayed on the display unit 14 of the taste-of-taking evaluation device 10, may be transmitted to an external device, or sound or light may be output. The above is the taste-of-taking evaluation method. In the case of the above-described taste-of-taking evaluation method, quantitative data such as a potential value is used. Therefore, the taste of taking a pharmaceutical preparation can be evaluated quantitatively rather than sensorially.

[0057] <Modification example> The present disclosure is not limited to the above-described embodiments, and includes various other modification examples. For example, the above-described embodiments have been described in detail for easy understanding of the present disclosure, and are not necessarily limited to those having all the configurations described. Also, a part of the configuration of one embodiment may be replaced with the configuration of another embodiment, and it is also possible to add the configuration of another embodiment to the configuration of one embodiment. Further, it is possible to add, delete, or replace a part of the configuration of each embodiment with another configuration.

[0058] In one embodiment of the present invention, an example in which the taste-of-taking evaluation device 10 and the electromyograph 30 are provided separately has been shown, but the present invention is not limited to this. The taste-of-taking evaluation device 10 and the electromyograph 30 may be provided integrally.

[0059] In one embodiment of the present invention, an example in which a capsule is used as a pharmaceutical preparation has been shown, but the present invention is not limited to this. For example, as a pharmaceutical preparation, in addition to a capsule, the same effect can be obtained by using any one of tablets, granules, and powders.

Example

[0060] Next, the present invention will be described in more detail based on examples. The following description is for easy understanding of the present invention and is not limited thereto. That is, modifications, embodiments, and other examples based on the technical idea of the present invention are all included in the present invention.

[0061] (1. Evaluation of the taste of taking a pharmaceutical preparation based on the impression (questionnaire) before taking the medicine) First, the evaluation results of the ease of taking a pharmaceutical preparation based on the impression before taking were conducted. In this evaluation, regarding the "ease of taking" of the capsule preparation judged by looking at and touching the capsule before taking, a 10-point evaluation was conducted by questionnaire. The evaluation conditions are as follows. Subjects: Healthy Japanese adults Age: 20 - 39 years old BMI (male): 19 - 24.9 BMI (female): 18.5 - 24.9 Male : Female (1:1) Number of subjects: 40 Preparation used: Placebo preparation (lactose) capsules No. 0 - 5 HPMC Test content: Evaluate the impression of "being easy to take" judged by looking at and touching on a 10-point scale (specifically, evaluate with 0 points for a very difficult-to-take and resistant case, and 10 points for an easy-to-take and non-resistant case).

[0062] Figure 10 is a graph showing the evaluation of the ease of taking a pharmaceutical preparation based on the impression before taking (questionnaire). As shown in Figure 10, in the evaluation of the ease of taking a pharmaceutical preparation by impression, as the capsule became smaller, the impression of ease of taking showed a tendency to be better (the value increased).

[0063] (2. Evaluation of the ease of taking a pharmaceutical preparation based on the impression (questionnaire) after taking) Next, the evaluation results of the ease of taking a pharmaceutical preparation based on the impression (questionnaire) after taking were conducted. In this evaluation, regarding the "ease of taking" of the tablet actually felt after taking the capsule preparation, a 10-point evaluation was conducted by questionnaire. The evaluation conditions are as follows. Subjects: Healthy Japanese adults Age: 20 - 39 years old BMI (male): 19 - 24.9 BMI (female): 18.5 - 24.9 Male : Female (1:1) Number of subjects: 40 Preparation used: Placebo preparation (lactose) capsules No. 0 - 5 HPMC Dosage method: Take 1 capsule with 20 mL of water (total of 6 times). · The dosing interval is approximately 5 minutes apart. · Posture during dosing: Sit on a chair, with the jaw horizontal. Test content: Actually take the medicine and evaluate the impression (feeling) of "was it easy to drink?" on a 10 - point scale (specifically, if it was very difficult to take and there was resistance, it was rated 0 points, and if it was easy to take and there was no resistance at all (the same as just water), it was rated 10 points).

[0064] Figure 11 is a graph showing the evaluation of the taste of pharmaceutical preparations based on the impression (questionnaire) after taking. As shown in Figure 11, also in the evaluation of the taste of pharmaceutical preparations based on the impression after taking, as the capsule size decreased, the taste became better (the numerical value increased).

[0065] (3. Correlation of the evaluation of the taste of pharmaceutical preparations based on the impression before and after taking) A correlation evaluation was conducted on the evaluation results of the taste of pharmaceutical preparations based on the impression before and after taking. Figure 12 shows the correlation evaluation results between the impression before taking and the impression (feeling) after taking. As shown in Figure 12, a high correlation was recognized between the taste evaluation results based on the impression before taking and the taste evaluation results based on the impression (feeling) of actually taking. That is, it was confirmed that there is a high correlation between the judgment based on visual (tactile) information and the actual taste.

[0066] (4. Evaluation of the taste of pharmaceutical preparations based on electromyogram measurement) Next, the evaluation results of the taste of pharmaceutical preparations based on electromyogram measurement were obtained. In this evaluation, a human electromyogram meter (manufactured by Trunk Solution) was worn for evaluation. The evaluation conditions are as follows. Subjects: Healthy Japanese adults Age: 20 - 39 years old BMI (male): 19 - 24.9 BMI (female): 18.5 - 24.9 Male : Female (1:1) Number of subjects: 40 Formulations used: Placebo formulations (lactose) capsules No. 0 - 5 of HPMC Dosage method: Take 1 capsule with 20 mL of water (6 times in total). · The dosing interval is about 5 minutes apart. · Posture during dosing: Sit on a chair with the jaw horizontal. Test content: Using an electromyogram, the muscle activity amount of the muscles related to swallowing was measured. The electromyogram was attached to the suprahyoid muscle group and the infrahyoid muscle group (see Figure 13). Analysis method: Taking the result when only 20 mL of water was taken as 1.00, for the electromyogram measurement values when taking the capsule, the ratios to water (maximum value ratio, total area ratio) were calculated. The condition of 20 mL of water was measured 3 times, and the average value of the 3 times was adopted. Between each formulation, a t-test (two-sided, paired) was performed, and a significance test was conducted at a significance level of 0.05.

[0067] Figure 14 shows the evaluation results of the swallowing feeling of pharmaceutical preparations based on the electromyogram measurement in the suprahyoid muscle group. Figure 15 shows the evaluation results of the swallowing feeling of pharmaceutical preparations based on the electromyogram measurement in the infrahyoid muscle group. As shown in Figure 14, in the evaluation results of the swallowing feeling with the electromyogram attached to the suprahyoid muscle group, an increase in the numerical value correlated with the capsule size was observed. Also, as shown in Figure 15, in the evaluation results of the swallowing feeling with the electromyogram attached to the infrahyoid muscle group, although variations in the numerical value fluctuations were seen when the capsule size was small, an increase in the numerical value corresponding to the capsule size was generally observed.

[0068] (5. Correlation between the impression after administration and the evaluation of the swallowing feeling of pharmaceutical preparations by electromyogram measurement) A correlation evaluation was performed on the impression after administration (questionnaire) and the evaluation results of the swallowing feeling of pharmaceutical preparations by electromyogram measurement. Note that the subjects in the evaluation by questionnaire and the evaluation by electromyogram measurement are the same. Figure 16 shows the correlation evaluation results between the impression after administration (questionnaire) and the evaluation of the swallowing feeling of pharmaceutical preparations by electromyogram measurement. The electromyogram measurement results used the total area ratio when the electromyogram was attached to the suprahyoid muscle group. As shown in Figure 16, a high correlation was observed between the questionnaire results of the swallowing feeling and the electromyogram evaluation value (suprahyoid muscle group, total area ratio). That is, it was confirmed that the electromyogram measurement is correlated with the actual difficulty of taking (swallowing feeling) and is useful as a quantitative evaluation method for the swallowing feeling of pharmaceutical preparations.

Description of Signs

[0069] 1 ··· Taste evaluation system, 10 ··· Taste evaluation device, 11 ··· Control unit, 11a ··· Acquisition unit, 11b ··· Generation unit, 11c ··· Judgment unit, 12 ··· Storage unit, 12a ··· Taste data database (DB), 13 ··· Communication unit, 14 ··· Display unit, 15 ··· Operation unit, 30 ··· Electromyograph, 31 ··· Control unit, 32 ··· Storage unit, 33 ··· Communication unit, 34 ··· Operation unit, 35 ··· Measurement unit

Claims

1. Attach a part of an electromyograph to the human body, obtain measurement data measured when taking a pharmaceutical preparation using the attached electromyograph, Generate information for evaluating the feeling of taking a pharmaceutical preparation based on the measurement data, A method for evaluating the feeling of taking a pharmaceutical preparation.

2. When measuring the measurement data, Attach the electromyograph to either the suprahyoid muscle group or the infrahyoid muscle group of the human body, The method for evaluating the feeling of taking a pharmaceutical preparation according to Claim 1.

3. After obtaining the measurement data, Perform root mean square processing on the first data included in the measurement data to generate second data, From the second data, adopt points that exceed the value obtained by adding twice the standard deviation to the average value of the baseline when the pharmaceutical preparation corresponding to the second data is not being taken to generate third data, Generate information for evaluating the feeling of taking a pharmaceutical preparation based on the third data, The method for evaluating the feeling of taking a pharmaceutical preparation according to Claim 1.

4. Generate information for evaluating the feeling of taking a pharmaceutical preparation based on the maximum value of the potential in the third data, The method for evaluating the feeling of taking a pharmaceutical preparation according to Claim 3.

5. Generate information for evaluating the feeling of taking a pharmaceutical preparation based on the area value generated from the third data, The method for evaluating the feeling of taking a pharmaceutical preparation according to Claim 3.

6. When the information for evaluating the feeling of taking a pharmaceutical preparation satisfies a predetermined condition, determine that it has a good feeling of taking, The method for evaluating the feeling of taking a pharmaceutical preparation according to Claim 1.

7. Notify the result of determining the feeling of taking, The method for evaluating the feeling of taking a pharmaceutical preparation according to Claim 6.

8. The pharmaceutical preparation is any one of a capsule, a tablet, a granule, and a powder, The method for evaluating the feeling of taking a pharmaceutical preparation according to Claim 1.

9. A program for executing the method for evaluating the feeling of taking according to any one of Claims 1 to 8.

10. Obtain measurement data measured when taking a pharmaceutical preparation using an electromyograph attached to the human body, An apparatus for evaluating the feeling of taking a pharmaceutical preparation, including a control unit that generates information for evaluating the feeling of taking a pharmaceutical preparation based on the measurement data An apparatus for evaluating the feeling of taking a pharmaceutical preparation.

11. When measuring the measurement data, Attach the electromyograph to either the suprahyoid muscle group or the infrahyoid muscle group of the human body, The apparatus for evaluating the feeling of taking a pharmaceutical preparation according to Claim 10.

12. The control unit, After obtaining the measurement data, Perform root mean square processing on the first data included in the measurement data to generate second data. From the second data, adopt points exceeding the value obtained by adding twice the standard deviation to the average value of the baseline when the pharmaceutical preparation corresponding to the second data is not taken, and generate third data. Generate information for evaluating the feeling of taking a pharmaceutical preparation when taking the pharmaceutical preparation based on the third data. The apparatus for evaluating the feeling of taking a pharmaceutical preparation according to claim 10.

13. The control unit Generates information for evaluating the feeling of taking a pharmaceutical preparation when taking the pharmaceutical preparation based on the maximum value of the potential in the third data. The apparatus for evaluating the feeling of taking a pharmaceutical preparation according to claim 12.

14. The control unit Generates information for evaluating the feeling of taking a pharmaceutical preparation when taking the pharmaceutical preparation based on the area value generated from the third data. The apparatus for evaluating the feeling of taking a pharmaceutical preparation according to claim 12.

15. The control unit Determines that it has a good feeling of taking when the information for evaluating the feeling of taking satisfies a predetermined condition. The apparatus for evaluating the feeling of taking a pharmaceutical preparation according to claim 10.

16. The control unit Notifies the result of determining the feeling of taking. The apparatus for evaluating the feeling of taking a pharmaceutical preparation according to claim 15.

17. The pharmaceutical preparation is any one of a capsule, a tablet, a granule, and a powder. The apparatus for evaluating the feeling of taking a pharmaceutical preparation according to any one of claims 10 to 16.

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