Turntable mechanism, cleaning device, and sample analyzer
The turntable mechanism with concentrically arranged setting and through-hole groups addresses the challenge of reducing the volume of immunoassay analyzers by optimizing vessel distribution and switching operations, achieving efficient cleaning and space utilization.
Patent Information
- Application Number
- JP2025009983
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-02-03
- Filing Date
- 2025-01-23
- Publication Date
- 2025-08-15
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Existing immunoassay analyzers face challenges in reducing the volume and space occupied by the cleaning device while maintaining efficient cleaning operations, as increasing the length of the magnetic attraction member to ensure sufficient cleaning time leads to a larger device size.
A turntable mechanism with concentrically arranged setting portion groups and through-hole groups, allowing for efficient distribution of reaction vessels and reduced volume, combined with a drive assembly and switching stations to facilitate synchronized waste liquid extraction and liquid injection operations.
The design reduces the volume of the cleaning device by optimizing vessel distribution and switching mechanisms, ensuring sufficient cleaning time without increasing the magnetic attraction member length, thus enhancing space efficiency and throughput.
Smart Images

Figure 2025120139000001_ABST
Abstract
Description
[Technical Field]
[0001] The present application relates to the technical field of medical equipment, and in particular to turntable mechanisms, cleaning devices and sample analyzers. [Background technology]
[0002] Taking immunoassay analyzers as an example of sample analyzers, immunoassay analyzers are highly sensitive and specific analytical instruments that have been rapidly developed around the world in recent years and are used in clinical laboratories to test and measure various immune indicators in samples such as blood, urine, and other body fluids.
[0003] In an immunoassay device, the reaction vessel after incubation is typically placed on the turntable of a cleaning device, and the reaction vessel rotates along with the turntable, passing alternately through a waste liquid extraction station and a liquid injection station. The waste liquid extraction mechanism in the cleaning device extracts the waste liquid from the reaction vessel located at the waste liquid extraction station, and the liquid injection mechanism in the cleaning device injects cleaning liquid into the reaction vessel located at the liquid injection station. After multiple waste liquid extractions and liquid injections, the specimen and impurities in the reaction vessel can be separated and cleaned.
[0004] The cleaning device further includes a magnetic attraction member extending along the circumferential direction of the turntable. When the reaction vessel enters the waste liquid extraction station, the magnetic attraction member interacts with the magnetic beads in the reaction vessel, allowing the specimen to be adsorbed to the inner wall of the reaction vessel via the magnetic beads. This allows the waste liquid extraction mechanism to extract the waste liquid, while the specimen remains in the reaction vessel, facilitating subsequent testing and measurement.
[0005] In order to increase the cleaning speed of the cleaning device, the residence time while the turntable rotates intermittently is shortened. However, in order to ensure the cleaning effect, it is necessary to ensure that the time it takes for the reaction vessel to pass through the magnetic attraction member does not change. Therefore, the length of the magnetic attraction member installed around the turntable must be increased. As a result, the number of reaction vessels that can be accommodated on the turntable also increases, leading to an increase in the volume of the cleaning device and the space it occupies. Summary of the Invention [Problem to be solved by the invention]
[0006] In light of this, it is necessary to provide a turntable mechanism, a cleaning device, and a sample analyzer that can reduce the volume in order to address the above-mentioned problems. [Means for solving the problem]
[0007] A turntable mechanism includes a turntable on which a plurality of setting portion groups for setting reaction vessels are formed around the turntable, all of the setting portion groups are arranged at intervals from the inside to the outside along the radial direction of the turntable, at least one round of through-hole groups is opened between two adjacent rounds of the setting portion groups, and all of the setting portions in the setting portion groups on each round and all of the through-holes in the through-hole groups on each round are arranged at intervals along the circumferential direction of the turntable, The set portion group on each periphery and the through-hole group on each periphery are both provided concentrically with the turntable.
[0008] In some embodiments, when the set portion group on one of two adjacent circumferences is an inner circumference set portion group and the set portion group on the other circumference is an outer circumference set portion group, the outer circumference set portion group is provided so as to surround the outer periphery of the inner circumference set portion group, all of the set portions in the set portion group on the inner periphery and all of the set portions in the set portion group on the outer periphery correspond one-to-one in the radial direction of the turntable and are arranged collinearly; Each of the through holes in the through hole group on each circumference located between the set portion group on the inner circumference and the set portion group on the outer circumference corresponds to at least one of the set portions in the set portion group on the inner circumference and the radial direction of the turntable within its own length along the circumferential direction of the turntable.
[0009] In some embodiments, each of the through holes in the through hole group on each circumference located between the set portion group on the inner circumference and the set portion group on the outer circumference corresponds to at least two of the set portions in the set portion group on the inner circumference and the radial direction of the turntable within a length range along the circumferential direction of the turntable.
[0010] In some embodiments, each of the through holes in the through hole group on each circumference located between the set portion group on the inner circumference and the set portion group on the outer circumference corresponds one-to-one with each of the set portions in the set portion group on the inner circumference in the radial direction of the turntable and is arranged collinearly.
[0011] In some embodiments, the turntable mechanism further includes a turntable drive assembly, the turntable drive assembly including a turntable motor, a turntable main driving wheel, a turntable driven wheel, and a turntable timing belt, the turntable motor is transmission-connected to the turntable main driving wheel, the turntable timing belt is wrapped around the outside of the turntable main driving wheel and the turntable driven wheel, and the turntable driven wheel is fixedly connected to the turntable.
[0012] A cleaning device comprising: The turntable mechanism according to any one of the above claims; a waste fluid extraction mechanism including N (N≧2) waste fluid extraction assemblies, each including a waste fluid extraction needle; a liquid injection mechanism including (N-1) liquid injection assemblies; the cleaning device has N waste liquid extraction stations, N cleaning stations, and (N-1) liquid injection stations, all of the waste liquid extraction stations and all of the cleaning stations correspond one-to-one to all of the waste liquid extraction assemblies, and all of the liquid injection stations correspond one-to-one to all of the liquid injection assemblies; the set portions on each periphery correspond to at least one set of the waste liquid extraction assemblies and at least one set of the liquid injection assemblies, the set portions on different peripheries correspond to different waste liquid extraction assemblies and different liquid injection assemblies, the through-hole groups on each periphery correspond to at least one of the cleaning stations, and the through-hole groups on different peripheries correspond to different cleaning stations; The waste liquid removal stations and the liquid injection stations are alternately provided along the rotation direction of the turntable.
[0013] In some embodiments, the cleaning apparatus further includes N first switching stations and N second switching stations, all of the first switching stations and all of the second switching stations are located on the top side of the turntable, all of the first switching stations and all of the second switching stations correspond one-to-one to all of the waste fluid extraction assemblies, the first switching stations and the waste fluid extraction stations corresponding to the same waste fluid extraction assemblies, and the second switching stations and the cleaning stations corresponding to the same waste fluid extraction assemblies are aligned in the axial direction of the turntable, and the waste fluid extraction assemblies are moved in a controlled manner, and the waste fluid extraction needles thereof are switched between the corresponding first switching stations and the second switching stations; the cleaning device further includes a lifting mechanism that is power-transmittedly connected to the waste liquid removal mechanism and drives the waste liquid removal mechanism to lift and lower the turntable along an axial direction; During the process of the waste fluid extraction mechanism rising, the waste fluid extraction needle of the waste fluid extraction assembly moves from the corresponding waste fluid extraction station to the corresponding first switching station, or moves from the corresponding washing station to the corresponding second switching station; As the waste fluid extraction mechanism descends, the waste fluid extraction needle in the waste fluid extraction assembly moves from the corresponding first switching station to the corresponding waste fluid extraction station, or moves from the corresponding second switching station to the corresponding washing station.
[0014] In some embodiments, the waste fluid extraction mechanism further includes a waste fluid extraction drive assembly that is transmission-connected to all of the waste fluid extraction assemblies and synchronously drives all of the waste fluid extraction assemblies to rotate or translate, thereby switching the waste fluid extraction needles of the waste fluid extraction assemblies between the corresponding first switching station and the second switching station.
[0015] In some embodiments, the set of portions is two-circumferential, including an inner set of portions and an outer set of portions; the cleaning device includes an inner peripheral switching station provided on a rotation path of the inner peripheral set unit group, the inner peripheral switching station being located downstream of all of the waste liquid removal stations and all of the liquid injection stations corresponding to the inner peripheral set unit group; and an outer peripheral switching station provided on a rotation path of the outer peripheral set unit group, the outer peripheral switching station being located upstream of all of the waste liquid removal stations and all of the liquid injection stations corresponding to the outer peripheral set unit group, When the reaction vessel located in the inner peripheral set section group has completed all waste liquid extraction and liquid injection operations corresponding to the inner peripheral set section group in the inner peripheral set section group and is moved to the inner peripheral switching station, it is transferred from the inner peripheral switching station to the set section of the outer peripheral set section group located in the outer peripheral switching station, and the waste liquid extraction and liquid injection operations corresponding to the outer peripheral set section group are continued in the outer peripheral set section group.
[0016] In some embodiments, the inner peripheral switching station and the outer peripheral switching station are located along the same radial direction of the turntable.
[0017] In some embodiments, the cleaning device includes a container loading station and a sub-loading station, both of which are provided on a rotation path of the set unit group on the inner periphery, the container loading station being located upstream of all of the waste liquid removal stations and all of the liquid injection stations corresponding to the set unit group on the inner periphery, and the sub-loading station being located downstream of all of the waste liquid removal stations and all of the liquid injection stations corresponding to the set unit group on the inner periphery, The container loading station is used to receive reaction containers transferred from a reaction apparatus, and when all waste liquid extraction and liquid injection operations corresponding to the outer peripheral set section group are completed in the outer peripheral set section group and the reaction container moves to the outer peripheral switching station, the reaction container is transferred from the outer peripheral switching station through the inner peripheral switching station to the sub-export station, and is then exported from the sub-export station to the reaction apparatus.
[0018] In some embodiments, the sub-output station overlaps with the container input station.
[0019] In some embodiments, the cleaning device further includes a transfer station provided on a rotation path of the inner peripheral set unit group and positioned between the inner peripheral switching station and the sub-discharge station; When all waste liquid extraction and all liquid injection operations corresponding to the outer peripheral set unit group are completed in the outer peripheral set unit group and the reaction vessel is moved to the outer peripheral switching station, the reaction vessel is transferred from the outer peripheral switching station to the inner peripheral switching station, and then moves to the sub-transport station via the transfer station, When the reaction vessel is located at the transfer station, the cleaning device is only used to transport the reaction vessel.
[0020] A sample analysis device comprising a washing device according to any one of the preceding claims. [Effects of the Invention]
[0021] In the above-described turntable mechanism, cleaning device, and sample analyzer, the turntable has multiple sets of loading sections for loading reaction vessels. During actual operation, the reaction vessels accommodated in one set of loading sections can be distributed among multiple sets of loading sections, reducing the number of reaction vessels accommodated in each set of loading sections. This reduces the number of reaction vessels in each set of loading sections, even when the turntable speed is increased. This ensures that the reaction vessels pass the magnetically attracted member for a sufficient time without increasing the length of the magnetically attracted member. In other words, even when the turntable speed is increased, the required time for the reaction vessels to pass the magnetically attracted member can be ensured without increasing the length of the magnetically attracted member or the circumference of the turntable. This design reduces the volume and occupies less space in the cleaning device. [Brief explanation of the drawings]
[0022] [Figure 1] 1 is a schematic diagram of a cleaning device according to an embodiment of the present invention; [Figure 2]FIG. 2 is a schematic configuration diagram of one aspect of the cleaning device shown in FIG. [Figure 3] 2 is a schematic diagram showing the configuration of the waste liquid removal mechanism, the lifting mechanism, and the turntable mechanism in cooperation with each other in the cleaning apparatus shown in FIG. 1. FIG. [Figure 4] 2 is a top view of the cleaning apparatus shown in FIG. 1 with a waste liquid removal mechanism and an elevation mechanism removed. [Figure 5] FIG. 5 is a top view of the cleaning device shown in FIG. 4 with the turntable removed. [Figure 6] 2 is a cross-sectional view showing the needle seat, waste liquid extraction bearing, waste liquid extraction bearing base, first waste liquid extraction needle, second waste liquid extraction needle, waste liquid extraction seat, and waste liquid extraction driven wheel in the cleaning device shown in FIG. DETAILED DESCRIPTION OF THE INVENTION
[0023] In order to make the above-mentioned objects, features and advantages of the present application more clearly understandable, specific embodiments of the present application will be described in detail below with reference to the drawings. In order to facilitate a full understanding of the present application, many specific details are set forth in the following description. However, the present application can be implemented in many ways different from those described herein, and those skilled in the art can make similar improvements without departing from the content of the present application, so the present application is not limited to the specific examples disclosed below.
[0024] In the description of this application, orientations or positional relationships indicated by terms such as "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are based on the drawings and are used only for ease of explanation or simplicity of explanation, and it should be understood that they do not represent or imply that the devices or elements shown necessarily have a specific orientation or a specific oriented structure and operation, and therefore should not be construed as limiting this application.
[0025] Additionally, the terms "first" and "second" are for descriptive purposes only and should not be understood to indicate or imply a relative importance or to implicitly indicate the number of technical features indicated. Thus, a feature qualified as "first" or "second" may explicitly or implicitly include one or more of such features. In the description of this application, unless explicitly and specifically limited, "plurality" means at least two, e.g., two or three.
[0026] In this application, unless otherwise clearly specified or limited, the terms "attach," "couple," "connect," "fixed," etc. should be understood in a broad sense, and may refer to, for example, a fixed connection, a detachable connection, or integration, a mechanical connection, an electrical connection, a direct connection, an indirect connection via an intermediate medium, internal communication between two elements, or an interactive relationship between two elements. Unless otherwise clearly limited, a person skilled in the art can understand the specific meaning of the above terms in this application depending on the specific situation.
[0027] In this application, unless otherwise clearly specified or limited, a first feature being "above" or "below" a second feature may mean that the first feature and the second feature are in direct contact, or that the first feature and the second feature are in indirect contact via an intermediate medium. Furthermore, a first feature being "above," "above," or "above" a second feature may mean that the first feature is directly above or diagonally above the second feature, or may simply mean that the first feature has a greater horizontal height than the second feature. A first feature being "below," "below," or "below" a second feature may mean that the first feature is directly below or diagonally below the second feature, or may simply mean that the first feature has a smaller horizontal height than the second feature.
[0028] It should be noted that when an element is described as being "fixed" or "mounted" to another element, it may be directly connected to the other element or there may be intervening elements. When an element is described as being "connected" to another element, it may be directly connected to the other element or there may be intervening elements. The terms "vertical," "horizontal," "top," "bottom," "left," "right," and similar terms used herein are for descriptive purposes only and do not imply the only embodiment.
[0029] The present application provides a sample analyzer for testing and measuring samples to provide a basis for clinical treatment decisions. The sample analyzer may be an immunoanalyzer, a blood coagulation analyzer, a blood cell analyzer, a urine analyzer, or the like, and the specific type is not limited thereto. For convenience of explanation, the following examples will be described using an immunoanalyzer as an example of the sample analyzer.
[0030] Referring to FIG. 1, the sample analysis apparatus includes a storage device, a transfer device, an injection device, a homogeneous mixing device, a reaction device, a washing device 1, and a measurement device. The storage device is used to store samples and reagents required for sample testing, and the transfer device is used to transfer reaction vessels 2 between the injection device, reaction device, washing device 1, and measurement device. The injection device is used to inject samples and reagents into reaction vessels 2, the homogeneous mixing device is used to homogeneously mix the samples and reagents, and the reaction device is used to place and transport reaction vessels 2. After homogeneous mixing, the sample and reagents can be incubated, allowing the sample to fully bind and react with the reagents and ensuring the accuracy of the sample testing. The washing device 1 is used to wash and remove impurities from reaction vessel 2 after incubation so that the sample remains in reaction vessel 2. The measurement device is used to test and measure the sample and obtain test measurement parameters of the sample that meet the testing measurement requirements.
[0031] For ease of understanding, the names of the sample and reagents at each stage will be explained in detail below. After the sample and reagents in the reaction vessel 2 are mixed, they are called a reaction solution, and the reaction device can perform an incubation operation on the reaction solution in the reaction vessel 2 so that the sample and reagents react sufficiently. After the reaction, the substances in the reaction vessel 2 are a specimen and impurities. That is, the reaction solution after the reaction exists in the form of a specimen and impurities. The impurities may be side reaction products generated by a side reaction, or other substances that affect the test measurement of the measurement device.
[0032] During actual operation of the sample analyzer, the specimen after the reaction is present in the reaction vessel 2 attached to the magnetic beads.
[0033] The storage device, transfer device, injection device, uniform mixing device and measuring device are all conventional in the art, and therefore their description will not be repeated here.
[0034] 1 again, and with reference to FIGS. 2, 3, and 4, the cleaning device 1 includes a turntable mechanism 10, a waste liquid removal mechanism 20, a liquid injection mechanism 30, a uniform mixing mechanism, a lifting mechanism 40, a cleaning mechanism 60, and a magnetic adsorption mechanism 50. The turntable mechanism 10 is used to place and transport the reaction vessel 2, the liquid injection mechanism 30 is used to inject a cleaning liquid into the reaction vessel 2, the uniform mixing mechanism is used to uniformly mix the cleaning liquid and the magnetic beads, and the waste liquid removal mechanism 20 is used to remove the waste liquid from the reaction vessel 2, which may be impurities or a mixed solution of impurities and a cleaning liquid. The lifting mechanism 40 is used to raise and lower the waste liquid extraction mechanism 20, the cleaning mechanism 60 is used to clean the waste liquid extraction needle of the waste liquid extraction mechanism 20 after the waste liquid has been extracted, and the magnetic adsorption mechanism 50 is used to attach magnetic beads to the wall surface of the reaction vessel 2, thereby allowing the specimen to follow the magnetic beads and be adsorbed to the wall surface of the reaction vessel 2 while the waste liquid is being extracted, thereby preventing the specimen from being extracted by the waste liquid extraction mechanism 20.
[0035] The turntable mechanism 10 includes a turntable 11 and a turntable drive assembly. The turntable 11 is provided with multiple circumferential setting section groups for setting reaction vessels 2, and all of the setting section groups are arranged radially from the inside to the outside of the turntable 11 at intervals. At least one circumferential through-hole group 113 is formed between two adjacent circumferential setting section groups. All of the setting sections 111a in each circumferential setting section group and all of the through-holes 113a in each circumferential through-hole group 113 are arranged at intervals along the circumferential direction of the turntable 11. The circumferential setting section groups and the circumferential through-hole groups 113 are all arranged concentrically with the turntable 11. The turntable drive assembly is power-transmittingly connected to the turntable 11 and is used to drive the turntable 11 to rotate around its own central axis (the rotation direction is indicated by arrow H in FIG. 2 ).
[0036] The setting part 111a is used for placing and transporting the reaction vessel 2, and the through-hole 113a is used for passing a waste liquid removal needle of the waste liquid removal mechanism 20. The setting part 111a has a through-hole structure.
[0037] The setting unit group may be two, three or more rounds, and in the example of Figure 2, the setting unit group is two rounds. The more rounds the setting unit group is provided, the more reaction vessels 2 the turntable 11 can carry, but the effect on the radial dimension of the turntable 11 is small, so the turntable 11 can carry many reaction vessels 2 while maintaining a small radial dimension, which is advantageous in reducing the space occupied by the sample analyzer and can improve the test throughput of the sample analyzer.
[0038] Of the two adjacent set portion groups, if one set portion group on one periphery is defined as the inner set portion group 111 and the other set portion group on the other periphery is defined as the outer set portion group 112, the outer set portion group 112 is arranged to surround the outer periphery of the inner set portion group 111. All of the set portions 111a of the inner set portion group 111 and all of the set portions 111a of the outer set portion group 112 are arranged collinearly in a one-to-one correspondence in the radial direction of the turntable 11. By shortening the distance between the two set portions 111a of the two adjacent set portion groups arranged collinearly, it is easy to quickly transfer the reaction vessel 2 along the radial direction of the turntable 11 between the two set portions 111a of the two adjacent set portion groups arranged collinearly, thereby improving transfer efficiency.
[0039] Between two adjacent sets of set portion groups, one, two or more sets of through holes 113 may be provided. Taking Fig. 2 as an example, one set of through holes 113 is provided between two adjacent sets of set portion groups.
[0040] For ease of explanation, the following embodiments will be described using an example in which the set portion groups in Figure 2 are two laps, including an inner lap set portion group 111 and an outer lap set portion group 112, and one lap of through hole group 113 is provided between the inner lap set portion group 111 and the outer lap set portion group 112.
[0041] For each of two adjacent set portion groups, each through hole 113a of the through hole group 113 located between the set portion group 111 on the inner circumference and the set portion group 112 on the outer circumference corresponds to at least one set portion 111a of the set portion group 111 on the inner circumference in the radial direction of the turntable 11 within its own length along the circumferential direction of the turntable 11.
[0042] For example, in some embodiments, for every two adjacent sets of set portions, each through hole 113a of each set of through holes 113 located between the inner set portion group 111 and the outer set portion group 112 corresponds, within its length along the circumferential direction of the turntable 11, to at least two sets 111a of the inner set portion group 111 in the radial direction of the turntable 11. Such a design allows the length of the through holes 113a to be increased, which facilitates reducing the weight of the turntable 11 and is advantageous for the turntable drive assembly to drive the turntable 11 and increase its speed.
[0043] For example, in some embodiments, for every two adjacent sets of set portions, each through hole 113a of each set of through holes 113 located between the set portion group 111 on the inner periphery and the set portion group 112 on the outer periphery corresponds one-to-one with each set portion 111a of the set portion group 111 on the inner periphery in the radial direction of the turntable 11, and is arranged collinearly. This design makes it possible to reduce the cutout area of the turntable 11, making it easy to maintain good mechanical strength of the turntable 11, and enabling the turntable 11 to stably and reliably mount many reaction vessels 2.
[0044] The turntable drive assembly includes a mounting seat 118, a turntable motor 114, a turntable driving wheel 115, a turntable driven wheel 116, and a turntable timing belt 117. The mounting seat 118 has a central hole 118a. The turntable motor 114, the turntable driving wheel 115, and the turntable timing belt 117 are all located at the bottom of the mounting seat 118. The turntable motor 114 is attached to the mounting seat 118 and is power-transmittingly connected to the turntable driving wheel 115. The turntable 11 is located at the top of the mounting seat 118. The turntable timing belt 117 is wound around the outside of the turntable driving wheel 115 and the turntable driven wheel 116. The turntable driven wheel 116 passes through the central hole 118a of the mounting seat 118 and is fixedly connected to the turntable 11.
[0045] During actual operation, the power of the turntable motor 114 is transmitted to the turntable 11 via the turntable driving wheel 115, the turntable timing belt 117, and the turntable driven wheel 116, thereby realizing the rotation of the turntable 11. A turntable driving assembly having such a structure has a simple structure, stable power transmission, and is advantageous in improving the rotation stability of the turntable 11.
[0046] Of course, the structure of the turntable drive assembly is not limited to the above-described one, and other structures are also possible. For example, in some embodiments, the turntable drive assembly may further include a turntable bearing pedestal and a turntable bearing, both of which are located on the bottom side of the mounting seat 118, with the turntable bearing fitted around the turntable driven wheel 116, and the turntable bearing pedestal being fitted around the turntable bearing and fixedly connected to the mounting seat 118. The turntable bearing pedestal and the turntable bearing contribute to improving the rotational stability of the turntable driven wheel 116 and ensuring the rotational reliability of the turntable 11. Also, for example, in some other embodiments, the turntable drive assembly may include only the turntable motor 114 that directly drives the turntable 11 to rotate.
[0047] The cleaning apparatus 1 has N waste liquid withdrawal stations, N cleaning stations, N first switching stations, N second switching stations, (N-1) liquid injection stations, and (N-1) uniform mixing stations, where N≧2 and N is a natural number. Specifically, N may be 2, 3, 4, etc., and in the example of FIG. 2, N is 4. For convenience of explanation, the following example will be described using an example where N is 4. In this example, there are four waste liquid withdrawal stations, cleaning stations, first switching stations, and second switching stations, and three liquid injection stations and three uniform mixing stations.
[0048] All the first switching stations and all the second switching stations are located on the top side of the turntable 11 .
[0049] The waste liquid extraction mechanism 20 includes a waste liquid extraction drive assembly 22 and N sets of waste liquid extraction assemblies 21, and the waste liquid extraction assemblies 21 include waste liquid extraction needles. The liquid injection mechanism 30 includes (N-1) sets of liquid injection assemblies 31, the uniform mixing mechanism includes (N-1) sets of uniform mixing assemblies, and the cleaning mechanism 60 includes N sets of cleaning assemblies 61. All of the waste liquid extraction stations, all of the cleaning stations, all of the first switching stations, and all of the second switching stations correspond one-to-one to all of the waste liquid extraction assemblies 21, and the first switching stations and waste liquid extraction stations corresponding to the same waste liquid extraction assembly 21, and the second switching stations and cleaning stations corresponding to the same waste liquid extraction assembly 21 are aligned in the axial direction of the turntable 11. Every liquid injection station has a one-to-one correspondence with every liquid injection assembly 31, every uniform mixing station has a one-to-one correspondence with every uniform mixing assembly, and every cleaning station has a one-to-one correspondence with every cleaning assembly 61.
[0050] For example, the cleaning assembly 61 may be a cleaning nozzle, a spray head, or other configurations. For convenience of explanation, the following embodiment will be described taking the cleaning assembly 61 as a cleaning nozzle.
[0051] The waste liquid extraction needle of each waste liquid extraction assembly 21 extracts waste liquid from a reaction vessel 2 located at a corresponding waste liquid extraction station and is moved to a corresponding washing station for cleaning. The waste liquid extraction needle of each waste liquid extraction assembly 21 can also switch its position between the corresponding first and second switching stations. Each liquid injection assembly 31 is used to inject cleaning liquid into a reaction vessel 2 located at a corresponding liquid injection station, and each uniform mixing assembly is used to uniformly mix the magnetic beads and cleaning liquid in a reaction vessel 2 located at a corresponding uniform mixing station. Each cleaning assembly 61 is used to clean the waste liquid extraction needle that has been moved to a corresponding washing station.
[0052] Each set of parts on each periphery corresponds to at least one waste liquid removal assembly 21 and at least one liquid injection assembly 31, and different set of parts on different peripheries correspond to different waste liquid removal assemblies 21 and different liquid injection assemblies 31. Each set of through holes 113 on each periphery corresponds to at least one cleaning station, and different sets of through holes 113 on different peripheries correspond to different cleaning stations. The waste liquid removal stations, liquid injection stations, and uniform mixing stations are alternately provided along the rotation direction of the turntable 11.
[0053] During actual operation, the turntable 11 is rotated by the turntable drive assembly, allowing each set section group on the circumference to alternately pass the reaction vessel 2 through the waste liquid extraction station, liquid injection station, and uniform mixing station corresponding to that set section group on the circumference, and also allowing the through-hole groups 113 to pass through positions aligned with the corresponding cleaning stations.
[0054] For ease of explanation, the following examples will be described using an example in which, in Figure 2, there are two sets of setting unit groups, including an inner set unit group 111 and an outer set unit group 112, with one set of through holes 113 between the inner set unit group 111 and the outer set unit group 112, four waste liquid extraction stations, four cleaning stations, four first switching stations, and four second switching stations, three liquid injection stations, three uniform mixing stations, four waste liquid extraction assemblies 21, four cleaning assemblies 61, and three liquid injection assemblies 31, and three uniform mixing assemblies, and after the waste liquid extraction, liquid injection, and uniform mixing operations are completed in the inner set unit group 111, the reaction vessel 2 is transferred to the outer set unit group 112, and the waste liquid extraction, liquid injection, and uniform mixing operations are performed again.
[0055] The first set of waste liquid extraction assemblies 21 corresponding to the inner peripheral set portion group 111 are referred to as first waste liquid extraction assemblies 21a, the second set of waste liquid extraction assemblies 21 corresponding to the inner peripheral set portion group 111 are referred to as second waste liquid extraction assemblies 21b, the first set of liquid injection assemblies 31 corresponding to the inner peripheral set portion group 111 are referred to as first liquid injection assemblies 31a, the second set of liquid injection assemblies 31 corresponding to the inner peripheral set portion group 111 are referred to as second liquid injection assemblies 31b, the first set of uniform mixing assemblies corresponding to the inner peripheral set portion group 111 are referred to as first uniform mixing assemblies, The second set of uniform mixing assemblies corresponding to the set portion group 111 on the outer periphery is defined as the second uniform mixing assembly, the first set of waste liquid extraction assemblies 21 corresponding to the set portion group 112 on the outer periphery is defined as the third waste liquid extraction assembly 21c, the second set of waste liquid extraction assemblies 21 corresponding to the set portion group 112 on the outer periphery is defined as the fourth waste liquid extraction assembly 21d, the first set of liquid injection assemblies 31 corresponding to the set portion group 112 on the outer periphery is defined as the third liquid injection assembly 31c, and the first set of uniform mixing assemblies corresponding to the set portion group 112 on the outer periphery is defined as the third uniform mixing assembly.
[0056] Furthermore, the waste liquid extraction station corresponding to the first set of waste liquid extraction assemblies 21 is defined as the first waste liquid extraction station 71, the first switching station corresponding to the first waste liquid extraction station 71 is located above the first waste liquid extraction station 71, and the cleaning station corresponding to the first set of waste liquid extraction assemblies 21 is defined as the first cleaning station. The waste liquid extraction station corresponding to the second set of waste liquid extraction assemblies 21 is defined as the second waste liquid extraction station 72, and the first switching station corresponding to the second waste liquid extraction station 72 is located above the second waste liquid extraction station 72, and the cleaning station corresponding to the second set of waste liquid extraction assemblies 21 is defined as the second cleaning station. The waste liquid extraction station corresponding to the third set of waste liquid extraction assemblies 21 is defined as the third waste liquid extraction station 73, the first switching station corresponding to the third waste liquid extraction station 73 is located above the third waste liquid extraction station 73, and the cleaning station corresponding to the third set of waste liquid extraction assemblies 21 is defined as the third cleaning station. The waste liquid extraction station corresponding to the fourth set of waste liquid extraction assemblies 21 is defined as the fourth waste liquid extraction station 74, and the first switching station corresponding to the fourth waste liquid extraction station 74 is located above the fourth waste liquid extraction station 74, and the cleaning station corresponding to the fourth set of waste liquid extraction assemblies 21 is defined as the fourth cleaning station.
[0057] Furthermore, the liquid injection station corresponding to first liquid injection assembly 31a is defined as first liquid injection station 75, the liquid injection station corresponding to second liquid injection assembly 31b is defined as second liquid injection station 76, and the liquid injection station corresponding to third liquid injection assembly 31c is defined as third liquid injection station 77. The uniform mixing station corresponding to the first uniform mixing assembly is defined as first uniform mixing station 78, the uniform mixing station corresponding to the second uniform mixing assembly is defined as second uniform mixing station 79, and the uniform mixing station corresponding to the third uniform mixing assembly is defined as third uniform mixing station 81.
[0058] Taking Figure 2 as an example, when the turntable 11 rotates, all of the set sections 111a in the set section group 111 on the inner periphery can pass the reaction vessel 2 sequentially through the first waste liquid removal station 71, the first liquid injection station 75, the first uniform mixing station 78, the second waste liquid removal station 72, the second liquid injection station 76, and the second uniform mixing station 79, while the set sections 111a in the set section group 112 on the outer periphery can pass the reaction vessel 2 sequentially through the third waste liquid removal station 73, the third liquid injection station 77, the third uniform mixing station 81, and the fourth waste liquid removal station 74. All of the through holes 113a in the through hole group 113 can sequentially pass through a position aligned with the second switching station and the first cleaning station corresponding to the first waste liquid extraction assembly, a position aligned with the second switching station and the second cleaning station corresponding to the second waste liquid extraction assembly, a position aligned with the second switching station and the third cleaning station corresponding to the third waste liquid extraction assembly, and a position aligned with the second switching station and the fourth cleaning station corresponding to the fourth waste liquid extraction assembly.
[0059] The first waste liquid removal assembly 21a, the first liquid injection assembly 31a, the first uniform mixing assembly, the second waste liquid removal assembly 21b, the second liquid injection assembly 31b, and the second uniform mixing assembly are arranged in sequence along the rotation direction of the turntable 11, and all are aligned with the set part group 111 on the inner periphery. The third waste liquid removal assembly 21c, the third liquid injection assembly 31c, the third uniform mixing assembly, and the fourth waste liquid removal assembly 21d are arranged in sequence along the rotation direction of the turntable 11, and all are aligned with the set part group 112 on the outer periphery.
[0060] During actual operation, the reaction vessel 2 set in the inner peripheral setting section group 111 passes through the first waste liquid draining station 71, the first liquid injection station 75, the first uniform mixing station 78, the second waste liquid draining station 72, the second liquid injection station 76, and the second uniform mixing station 79, and within the same time period, the first waste liquid draining station 71, the first liquid injection station 75, the first uniform mixing station 78, the second waste liquid draining station 72, the second liquid injection station 76, and the second uniform mixing station 79 all contain a reaction vessel 2. The first waste liquid draining assembly 21a is used to drain the waste liquid from the reaction vessel 2 at the first waste liquid draining station 71, the first liquid injection assembly 31a is used to inject a washing liquid into the reaction vessel 2 at the first liquid injection station 75, and the first uniform mixing assembly is used to uniformly mix the washing liquid and magnetic beads at the first uniform mixing station 78. The second waste liquid extraction assembly 21b is used to extract waste liquid from the reaction vessel 2 at the second waste liquid extraction station 72, the second liquid injection assembly 31b is used to inject a washing liquid into the reaction vessel 2 at the second liquid injection station 76, and the second uniform mixing assembly is used to uniformly mix the washing liquid and magnetic beads in the reaction vessel 2 at the second uniform mixing station 79. After the reaction vessel 2 has completed two waste liquid extractions, two liquid injections, and two uniform mixings at the inner peripheral set unit group 111, it moves to the outer peripheral set unit group 112 and sequentially passes through the third waste liquid extraction station 73, the third liquid injection station 77, the third uniform mixing station 81, and the fourth waste liquid extraction station 74. Within the same time period, the third waste liquid extraction station 73, the third liquid injection station 77, the third uniform mixing station 81, and the fourth liquid injection station all contain reaction vessels 2.The third waste liquid extraction assembly 21c is used to extract waste liquid from the reaction vessel 2 at the third waste liquid extraction station 73, the third liquid injection assembly 31c is used to inject cleaning liquid into the reaction vessel 2 at the third liquid injection station 77, the third uniform mixing assembly is used to uniformly mix the cleaning liquid and magnetic beads in the reaction vessel 2 at the third uniform mixing station 81, and the fourth waste liquid extraction assembly 21d is used to extract waste liquid from the reaction vessel 2 at the fourth waste liquid extraction station 74. After the reaction vessel 2 has undergone two waste liquid extractions, one injection of cleaning liquid, and one uniform mixing in the outer peripheral set group 112, the complete flow of waste liquid extraction, liquid injection, and uniform mixing is completed. The reaction vessel is transported from the outer peripheral set part group 112 and reaches the measuring device for inspection and measurement, or is transferred back to the reaction device, where reagents are added again to cause a reaction, and then transferred to the inner peripheral set part group 111, where waste liquid removal, liquid injection, and uniform mixing operations corresponding to the inner peripheral set part group 111 and the outer peripheral set part group 112 are completed before being transported.
[0061] In such an embodiment, by providing N sets of waste liquid extraction assemblies 21, (N-1) sets of liquid injection assemblies 31, (N-1) sets of uniform mixing assemblies, N waste liquid extraction stations, N washing stations, N first switching stations, N second switching stations, (N-1) liquid injection stations, (N-1) uniform mixing stations and multiple round set unit groups, waste liquid extraction from N reaction vessels 2, injection of washing liquid into (N-1) reaction vessels 2, and uniform mixing of (N-1) reaction vessels 2 can be performed synchronized, which is advantageous for improving the efficiency of the sample analysis device.
[0062] The waste extraction assembly 21 is moved by the waste extraction drive assembly 22 to switch its waste extraction needle between the corresponding first and second switching stations.
[0063] The lifting mechanism 40 is power-transmittedly connected to the waste liquid extraction mechanism 20 and is used to drive the waste liquid extraction mechanism 20 up and down along the axial direction of the turntable 11. When the lifting mechanism 40 drives the waste liquid extraction mechanism 20 up, the waste liquid extraction needles of the waste liquid extraction assembly 21 move from the corresponding waste liquid extraction station to the corresponding first switching station, or move from the corresponding cleaning station to the corresponding second switching station through the aligned through-holes 113a. When the waste liquid extraction mechanism 20 descends, the waste liquid extraction needles of the waste liquid extraction assembly 21 move from the corresponding first switching station to the corresponding waste liquid extraction station, or move from the corresponding second switching station to the corresponding cleaning station through the aligned through-holes 113a.
[0064] The number of waste liquid extraction assemblies 21 is the same as the number of waste liquid extraction drive assemblies 22, and they correspond one-to-one, and different waste liquid extraction drive assemblies 22 may be used to drive the movement of different waste liquid extraction assemblies 21. Preferably, the waste liquid extraction drive assemblies 22 are transmission-connected to all of the waste liquid extraction assemblies 21 and synchronously drive all of the waste liquid extraction assemblies 21 to rotate or translate, thereby switching the waste liquid extraction needles of the waste liquid extraction assemblies 21 between the corresponding first and second switching stations. By designing N sets of waste liquid extraction assemblies 21 to share the same waste liquid extraction drive assembly 22, the number of waste liquid extraction drive assemblies 22 can be reduced, which facilitates simplifying the structure of the cleaning apparatus 1 and reducing the weight of the cleaning apparatus 1.
[0065] Specifically, the waste liquid extraction drive assembly 22 synchronously drives all of the waste liquid extraction assemblies 21 to translate or rotate, thereby switching the waste liquid extraction needles of the waste liquid extraction assemblies 21 between the corresponding first and second switching stations. For example, the waste liquid extraction drive assembly 22 drives the waste liquid extraction assemblies 21 to translate along the radial direction of the turntable 11, thereby switching the waste liquid extraction needles between the first and second switching stations. Also, for example, the waste liquid extraction assembly 21 includes a needle seat 211 and a waste liquid extraction needle attached to the needle seat 211, and the waste liquid extraction drive assembly 22 can rotate the needle seats 211 of all of the waste liquid extraction assemblies 21, thereby rotating the waste liquid extraction needles of all of the waste liquid extraction assemblies 21, thereby switching the waste liquid extraction needles of all of the waste liquid extraction assemblies 21 between the first and second switching stations.
[0066] For ease of explanation, the following embodiment will be described using an example in which the waste liquid extraction drive assembly 22 synchronously drives and rotates all of the waste liquid extraction assemblies 21, thereby switching the waste liquid extraction needles of the waste liquid extraction assemblies 21 between the corresponding first and second switching stations.
[0067] 1 and 2, in this embodiment, as an example, the waste liquid extraction drive assembly 22 includes a waste liquid extraction seat 221, a waste liquid extraction motor 222, a waste liquid extraction main wheel 223, a waste liquid extraction timing belt 224, and N waste liquid extraction driven wheels 225. The waste liquid extraction motor 222 and all of the waste liquid extraction driven wheels 225 are both mounted on the waste liquid extraction seat 221, the waste liquid extraction driven wheels 225 are rotatable relative to the waste liquid extraction seat 221, the waste liquid extraction motor 222 is transmission-connected to the waste liquid extraction main wheel 223, and the waste liquid extraction timing belt 224 is wound around the outside of the waste liquid extraction main wheel 223 and all of the waste liquid extraction driven wheels 225. All of the waste liquid extraction driven wheels 225 correspond one-to-one to the needle seats 211 of all of the waste liquid extraction assemblies 21, and each waste liquid extraction driven wheel 225 is fixedly connected to the corresponding needle seat 211.
[0068] When the waste liquid extraction drive assembly 22 is activated, the power of the waste liquid extraction motor 222 is transmitted to the needle seat 211 of each waste liquid extraction assembly 21 via the waste liquid extraction main wheel 223, the waste liquid extraction timing belt 224 and each waste liquid extraction driven wheel 225, thereby allowing each needle seat 211 to rotate the waste liquid extraction needle attached to it and switch between the first switching station and the second switching station.
[0069] The waste liquid removal drive assembly 22 configured in this manner has stable power transmission and high operational accuracy.
[0070] In some embodiments, the waste liquid extraction drive assembly 22 further includes at least N tension wheels 226, all of which are provided on the waste liquid extraction seats 221, all of which are located outside the waste liquid extraction timing belt 224, and all of which are in contact with the outer surface of the waste liquid extraction timing belt 224. In the winding direction of the waste liquid extraction timing belt 224, at least one tension wheel 226 is in contact with each segment of the waste liquid extraction timing belt 224 which is located between two adjacent waste liquid extraction driven wheels 225, and each segment which is located between adjacent waste liquid extraction main wheels 223 and waste liquid extraction driven wheels 225.
[0071] The tension wheel 226 can apply tension to the waste liquid removal timing belt 224 of each segment, which is advantageous in that the waste liquid removal timing belt 224 allows the waste liquid removal driven wheel 225 to operate stably and reliably.
[0072] Referring also to Figure 6, the waste liquid extraction drive assembly 22 further includes a waste liquid extraction bearing 227 and a waste liquid extraction bearing base 228, the needle seat 211 includes a seat body 211a and a shaft portion 211b, the waste liquid extraction needle is attached to the seat body 211a, the shaft portion 211b is fixedly connected between the seat body 211a and the waste liquid extraction driven wheel 225, the waste liquid extraction bearing 227 is rotatably inserted onto the shaft portion 211b, and the waste liquid extraction bearing base 228 is attached to the waste liquid extraction seat 221 and inserted onto the waste liquid extraction bearing 227.
[0073] The provision of the waste liquid extraction bearing 227 and the waste liquid extraction bearing stand 228 is advantageous in improving the rotational stability of the shaft portion 211b, which in turn improves the rotational stability of the waste liquid extraction needle. Therefore, the waste liquid extraction needle can accurately switch stations.
[0074] The same waste liquid extraction assembly 21 may include one or two waste liquid extraction needles, preferably two, and if the two waste liquid extraction needles are defined as a first waste liquid extraction needle 212 and a second waste liquid extraction needle 213, respectively, the first waste liquid extraction needle 212 and the second waste liquid extraction needle 213 are both attached to the seat body 211a.
[0075] The waste liquid extraction drive assembly 22 causes the needle seat 211 to synchronously revolve the first waste liquid extraction needle 212 and the second waste liquid extraction needle 213, thereby alternately switching the first waste liquid extraction needle 212 and the second waste liquid extraction needle 213 between the first switching station and the second switching station.
[0076] When the waste liquid extraction assembly 21 is provided with a first waste liquid extraction needle 212 and a second waste liquid extraction needle 213, the second waste liquid extraction needle 213 can be cleaned while the first waste liquid extraction needle 212 is extracting waste liquid, and then, when the next reaction vessel 2 is moved to the waste liquid extraction station, by switching between the first waste liquid extraction needle 212 and the second waste liquid extraction needle 213, the second waste liquid extraction needle 213 can be used to extract waste liquid from the reaction vessel 2 located at the waste liquid extraction station, and the first waste liquid extraction needle 212 can be moved to the cleaning station to be cleaned. In other words, by alternately using the first waste liquid extraction needle 212 and the second waste liquid extraction needle 213, the waste liquid extraction operation and the cleaning operation can be performed simultaneously, and the cleaned waste liquid extraction needle can be reused for the next waste liquid extraction, which significantly reduces the waiting time for cleaning the waste liquid extraction needle and is advantageous for increasing the testing and measurement speed of the sample analysis device.
[0077] 3 again, the lifting mechanism 40 includes a lifting motor 41, a lifting main wheel 42, a lifting rack 43, and a lifting rod 44. The lifting motor 41 is power-transmittingly connected to the lifting main wheel 42, the lifting main wheel 42 meshes with the lifting rack 43, and the lifting rod 44 is fixedly connected to the lifting rack 43. The lifting rod 44 is inserted into a central hole 118a of the mounting seat 118 and connected to the waste liquid removal mechanism 20. The lifting motor 41 drives the lifting main wheel 42 to raise and lower the lifting rack 43, the lifting rod 44, and the waste liquid removal mechanism 20.
[0078] Referring again to FIG. 4 and to FIG. 5, the magnetic attraction mechanism 50 includes a plurality of magnetic attraction members, the number of which is the same as the number of waste liquid drainage stations, in a one-to-one correspondence, and each magnetic attraction member extends to a corresponding waste liquid drainage station along the rotation direction of the turntable 11. Each magnetic attraction member is used to collect magnetic beads in the reaction vessel 2 and attract them to the inner wall of the reaction vessel 2 on the path where the reaction vessel 2 placed in the setting unit 111a enters the waste liquid drainage station corresponding to the magnetic attraction member. As a result, when the reaction vessel 2 enters the waste liquid drainage station corresponding to the magnetic attraction member and waste liquid is drained, the sample can follow the magnetic beads and remain in the reaction vessel 2, facilitating subsequent testing and measurement.
[0079] The cleaning device 1 includes a container loading station 82 and an outer peripheral switching station 83, where the container loading station 82 refers to the initial station where the reaction container 2 after incubation is transferred to the turntable 11, and the outer peripheral switching station 83 refers to the station where the reaction container 2 is transferred between the inner peripheral set unit group 111 and the outer peripheral set unit group 112, and is also the container unloading station where the reaction container 2 after cleaning is unloaded from the turntable 11.
[0080] The container carrying station 82 is located on the rotation path of the inner peripheral setting unit group 111, and the outer peripheral switching station 83 is located on the rotation path of the outer peripheral setting unit group 112.
[0081] There are four magnetic attraction members, and if the four magnetic attraction members are defined as a first magnetic attraction member 51, a second magnetic attraction member 52, a third magnetic attraction member 53, and a fourth magnetic attraction member 54, in the rotation direction of the turntable 11, the first magnetic attraction member 51 extends from a station located between the container carry-in station 82 and the first waste liquid draining station 71 to the first waste liquid draining station 71, and the second magnetic attraction member 52 extends from a station located between the first uniform mixing station 78 and the second waste liquid draining station 71 to the first uniform mixing station 78. The first magnetic attraction member 53 extends from a station located between the outer peripheral switching station 83 and the third waste liquid extraction station 73 to the third waste liquid extraction station 73, and the fourth magnetic attraction member 54 extends from a station located between the third uniform mixing station 81 and the fourth waste liquid extraction station 74 to the fourth waste liquid extraction station 74. It should be noted that there is no need for a magnetic attraction member at each liquid injection station and each uniform mixing station. Only in this way can the liquid injection assembly 31 disperse the gathered magnetic beads when it injects the washing liquid into the reaction vessel 2 located at the corresponding liquid injection station, ensuring that the uniform mixing assembly can uniformly mix the washing liquid and the magnetic beads.
[0082] To lengthen the attraction time of the magnetic attraction members, the first magnetic attraction member 51 should be as close as possible to the container carry-in station 82, the second magnetic attraction member 52 should be as close as possible to the first uniform mixing station 78, the third magnetic attraction member 53 should be as close as possible to the outer peripheral switching station 83, and the fourth magnetic attraction member 54 should be as close as possible to the third uniform mixing station 81. When the turntable 11 rotates once, the reaction container 2 located at the container carry-in station 82 can be rotated into the attraction area of the first magnetic attraction member 51, the reaction container 2 located at the first uniform mixing station 78 can be rotated into the attraction area of the second magnetic attraction member 52, the reaction container 2 located at the outer peripheral switching station 83 can be rotated into the attraction area of the third magnetic attraction member 53, and the reaction container 2 located at the third uniform mixing station 81 can be rotated into the attraction area of the fourth magnetic attraction member 54.
[0083] 1 and 2, and referring to FIG. 4, in some embodiments of the present application, the set unit group has two circumferences, including an inner set unit group 111 and an outer set unit group 112. The cleaning apparatus 1 includes an inner peripheral switching station 84 and an outer peripheral switching station 83, the inner peripheral switching station 84 is provided on the rotation path of the inner peripheral set unit group 111 and is located downstream of all of the waste liquid removal stations and all of the liquid injection stations corresponding to the inner peripheral set unit group 111, and the outer peripheral switching station 83 is provided on the rotation path of the outer peripheral set unit group 112 and is located upstream of all of the waste liquid removal stations and all of the liquid injection stations corresponding to the outer peripheral set unit group 112.
[0084] When the reaction vessel 2 located in the inner peripheral set section group 111 has completed all waste liquid extraction and liquid injection operations corresponding to the inner peripheral set section group 111 in the inner peripheral set section group 111 and moved to the inner peripheral switching station 84, it is transferred from the inner peripheral switching station 84 to the set section 111a of the outer peripheral set section group 112 located in the outer peripheral switching station 83, and the waste liquid extraction and liquid injection operations corresponding to the outer peripheral set section group 112 are continued in the outer peripheral set section group 112.
[0085] When all waste liquid extraction and liquid injection operations corresponding to the outer peripheral set part group 112 have been completed in the outer peripheral set part group 112, the reaction vessel 2 is moved to the outer peripheral switching station 83, and then transferred from the outer peripheral switching station 83 to a measuring device or a switching station 84 on the inner peripheral of the reaction vessel 2.
[0086] Taking an example of an inspection or measurement item using the one-step method, a reaction vessel 2 that has reacted in a reaction apparatus is transferred by a transfer device to the inner peripheral set unit group 111, and passes alternately through the waste liquid removal station, liquid injection station, and uniform mixing station corresponding to the inner peripheral set unit group 111. After all of the waste liquid removal operations, liquid injection operations, and uniform mixing operations corresponding to the inner peripheral set unit group 111 have been completed, the set unit 111a of the inner peripheral set unit group 111 on which the reaction vessel 2 is placed moves to the inner peripheral switching station 84. Next, the transfer device transfers the reaction vessel 2 located at the inner peripheral switching station 84 to the set unit 111a located at the outer peripheral switching station 83 of the outer peripheral set unit group 112. Thereafter, the reaction vessel 2 is transported by the outer peripheral setting unit group 112, and alternately passes through the waste liquid removal station, liquid injection station, and uniform mixing station corresponding to the outer peripheral setting unit group 112, and performs all of the waste liquid removal operation, liquid injection operation, and uniform mixing operation corresponding to the outer peripheral setting unit group 112. Next, the setting unit 111a of the outer peripheral setting unit group 112 places the reaction vessel 2 on it and returns it to the outer peripheral switching station 83, and the transfer device transfers the reaction vessel 2 to the measurement device for inspection and measurement.
[0087] Taking a two-step inspection / measurement item as an example, the difference between a two-step inspection / measurement item and a one-step inspection / measurement item is that when a reaction vessel 2 placed in the outer peripheral set unit group 112 undergoes all of the waste liquid removal, liquid injection, and uniform mixing operations corresponding to the outer peripheral set unit group 112 returns to the outer peripheral switching station 83, the transfer device transfers the reaction vessel 2 in that set unit 111a to the set unit 111a of the inner peripheral set unit group 111 located at the inner peripheral switching station 84. Next, the reaction vessel 2 moves from the inner peripheral set unit group 111 to a work area where the transfer device transfers the reaction vessel 2 between the reaction device and the cleaning device 1. The transfer device then transfers the reaction vessel 2 back to the reaction device, allowing the reaction vessel 2 to later undergo secondary reagent addition and secondary reaction. After the secondary reaction is completed, the reaction vessel 2 returns to the cleaning device 1 for secondary cleaning, and after cleaning is completed, it is transferred to the measurement device to complete the inspection and measurement. The operation for secondary cleaning of the reaction vessel 2 is exactly the same as that for the inspection and measurement items of the one-step method, and therefore a description thereof will be omitted here.
[0088] The operation of adding the secondary reagent to the reaction vessel 2 and the secondary reaction may both be performed on the reaction apparatus, or the reaction vessel 2 may be relayed only in the reaction apparatus, and the reaction vessel 2 may be moved to an injection device to perform the secondary reagent addition operation, and then the reaction vessel 2 may be returned to the reaction apparatus to perform the secondary reaction.
[0089] After the waste liquid removal, liquid injection, and uniform mixing operations are completed in the inner peripheral set unit group 111, the reaction vessel 2 is transferred to the outer peripheral set unit group 112 via the inner peripheral switching station 84 and the outer peripheral switching station 83, where the waste liquid removal, liquid injection, and uniform mixing operations are performed again. That is, after the reaction vessel 2 has completed cleaning corresponding to the inner peripheral set unit group 111 in the inner peripheral set unit group 111, it is transferred to the outer peripheral set unit group 112 via the inner peripheral switching station 84 and the outer peripheral switching station 83, where the remaining cleaning can be continued. The same reaction vessel 2 can be repeatedly cleaned in the inner peripheral set unit group 111 and the outer peripheral set unit 111a. Furthermore, the reaction vessels 2 located in the inner peripheral set unit group 111 and the outer peripheral set unit group 112 can be cleaned simultaneously. This satisfies the cleaning quality and cleaning speed while allowing the turntable 11 to be sufficiently small, the structure to be compact, and the space occupied by the cleaning device 1 to be reduced.
[0090] Furthermore, in some embodiments of the present application, the inner peripheral switching station 84 and the outer peripheral switching station 83 are located along the same radial direction of the turntable 11 .
[0091] In such a design, the transfer device can transfer the reaction vessel 2 along the radial direction of the turntable 11 between the setting unit 111a located at the switching station 84 on the inner periphery and the setting unit 111a located at the switching station 83 on the outer periphery. This minimizes the path along which the reaction vessel 2 in the cleaning device 1 is transferred between the group of setting units 111 on the inner periphery and the group of setting units 112 on the outer periphery, increasing the transfer efficiency and thereby improving the testing and measurement efficiency of the sample analyzer.
[0092] Typically, the measurement device and the outer peripheral switching station 83 are aligned in the same radial direction of the turntable 11. The transfer device includes a container carrying-out / gripping mechanism that transfers the reaction container 2 located at the outer peripheral switching station 83 to the measurement device for inspection and measurement. If the inner peripheral switching station 84 and the outer peripheral switching station 83 are arranged along the same radial direction of the turntable 11, the container carrying-out / gripping mechanism can also grip the reaction container 2 and transfer it between the outer peripheral switching station 83 and the inner peripheral switching station 84. In other words, the same container carrying-out / gripping mechanism is shared for transferring the reaction container 2 between the inner peripheral setting unit group 111 and the outer peripheral setting unit group 112 and for removing the reaction container 2, thereby simplifying the configuration of the sample analysis device 1.
[0093] In some embodiments of the present application, the cleaning apparatus 1 has a sub-extraction station 85, and the container loading station 82 and the sub-extraction station 85 are both arranged on the rotation path of the inner peripheral set unit group 111, and the container loading station 82 is located upstream of all the waste liquid removal stations and all the liquid injection stations corresponding to the inner peripheral set unit group 111, and the sub-extraction station 85 is located downstream of all the waste liquid removal stations and all the liquid injection stations corresponding to the inner peripheral set unit group 111.
[0094] The container loading station 82 is used to receive the reaction container 2 transferred from the reaction apparatus, and when all waste liquid extraction and liquid injection operations corresponding to the outer peripheral set section group 112 have been completed in the outer peripheral set section group 112 and the reaction container 2 is moved to the outer peripheral switching station 83, the reaction container 2 is transferred from the outer peripheral switching station 83 through the inner peripheral switching station 84 to the sub-export station 85, and then transferred from the sub-export station 85 to the reaction apparatus.
[0095] The vessel loading station 82 is located in the working area where the transfer device transfers the reaction vessels 2 between the reactor and the cleaning device 1 .
[0096] The sub-extraction station 85 may overlap with the container loading station 82, or the sub-extraction station 85 may be provided at a distance from the container loading station 82, and specifically can be provided as needed. In the two-step method inspection and measurement item, the reaction container 2 on the reaction apparatus is transferred by the transfer device to the set unit 111a of the inner peripheral set unit group 111 located at the container loading station 82, and after the cleaning corresponding to the inner peripheral set unit group 111 is completed in the inner peripheral set unit group 111, it is transferred to the outer peripheral set unit group 112 via the inner peripheral switching station 84 and the outer peripheral switching station 83, where the remaining cleaning is continued.
[0097] Next, after cleaning corresponding to the outer peripheral set unit group 112 is completed, the reaction vessel 2 is switched from the set unit 111a located at the outer peripheral switching station 83 to the set unit 111a of the inner peripheral set unit group 111 located at the inner peripheral switching station 84, and then the turntable 11 rotates to transport the reaction vessel 2 to the sub-exit station 85, and then the transfer device transports the reaction vessel 2 in the set unit 111a located at the sub-exit station 85 back to the reaction apparatus.
[0098] By designing both the container loading station 82 and the sub-export station 85 to be located on the rotation path of the inner peripheral set section group 111, the reaction container 2 can be transferred between the reaction device and the cleaning device 1 on the same circumference, making it easier to operate the transfer device and advantageous for improving the compactness of the layout of the sample analysis device.
[0099] Additionally, in some embodiments of the present application, the sub-exit station 85 overlaps with the container input station 82 .
[0100] In this design, the path along which the transfer device transfers the reaction vessel 2 from the reaction device to the cleaning device 1 is completely identical to the path along which it transfers the reaction vessel 2 from the cleaning device 1 to the reaction device, which makes the movement path of the transfer device simpler and simplifies the structure of the transfer device, which is advantageous in reducing the space occupied by the sample analysis device.
[0101] In some embodiments of the present application, the cleaning apparatus 1 further includes a transfer station 86 that is provided on the rotation path of the inner peripheral set unit group 111 and is located between the inner peripheral switching station 84 and the sub-transport station 85. When the outer peripheral set unit group 112 has completed all waste liquid removal and liquid injection operations corresponding to the outer peripheral set unit group 112 and moved to the outer peripheral switching station 83, the reaction vessel 2 is transferred from the outer peripheral switching station 83 to the inner peripheral switching station 84, and then moves to the sub-transport station 85 via the transfer station 86. When the reaction vessel 2 is located at the transfer station 86, the cleaning apparatus 1 is used only to transport the reaction vessel 2.
[0102] The transfer station 86 is used to transfer the reaction vessel 2 located at the inner peripheral switching station 84 to the sub-exit station 85, thereby facilitating the reaction vessel 2 being transferred from the sub-exit station 85 to the reaction apparatus.
[0103] Because the reaction vessel 2 located at the transfer station 86 has already undergone four waste liquid extraction operations, there is no need to provide a magnetic attraction member at the transfer station 86. By providing the transfer station 86, the reaction vessel 2 can be transferred using an empty station between the inner peripheral switching station 84 and the sub-transport station 85, thereby maximizing station usage.
[0104] The overall operation of the cleaning device 1 will now be described in detail.
[0105] After incubation, the reaction vessel 2 is transferred by a transfer device to the inner peripheral set section group 111 and rotated to the set section 111a of the vessel loading station 82, and then the turntable 11 rotates to pass the reaction vessel 2 sequentially through the first waste liquid extraction station 71, the first liquid injection station 75, the first uniform mixing station 78, the second waste liquid extraction station 72, the second liquid injection station 76 and the second uniform mixing station 79.
[0106] As the reaction vessel 2 moves to the first waste liquid draining station 71, the magnetic beads in the reaction vessel 2 are collected by the first magnetic attraction member 51. When the reaction vessel 2 moves to the first waste liquid draining station 71, the first waste liquid draining assembly 21a descends, and the first waste liquid draining needle 212 of the first waste liquid draining assembly 21a enters the reaction vessel 2 and drains the post-reaction waste liquid from the reaction vessel 2. At the same time, the second waste liquid draining needle 213 of the first waste liquid draining assembly 21a enters the first washing station through the aligned through-hole 113a and is washed. Because the first magnetic attraction member 51 can collect the magnetic beads and adsorb them to the inner wall of the reaction vessel 2, the magnetic beads and the specimen remain in the reaction vessel 2 even after the operation of the first waste liquid draining needle 212 is completed. The first waste liquid extraction assembly 21a then rises, the first waste liquid extraction needle 212 in the first waste liquid extraction assembly 21a retracts to the first switching station, and the second waste liquid extraction needle 213 in the first waste liquid extraction assembly 21a retracts to the second switching station.
[0107] After the waste liquid has been removed from the reaction vessel 2 at the first waste liquid removal station 71, the reaction vessel 2 is carried by the turntable 11 into the first liquid injection station 75, where the liquid is injected. As the reaction vessel 2 enters the first liquid injection station 75, the first waste liquid removal assembly 21a rotates, causing the first waste liquid removal needle 212 to move to the second switching station and the second waste liquid removal needle 213 to move to the first switching station. When the next reaction vessel 2 enters the first waste liquid removal station 71, the second waste liquid removal needle 213 descends and enters the next reaction vessel 2 to remove the waste liquid, and the first waste liquid removal needle 212 passes through the aligned through-holes 113a into the first cleaning station to be cleaned. This completes one waste liquid extraction cycle for the first waste liquid extraction assembly 21a, and thereafter, the first waste liquid extraction assembly 21a circulates the extraction of waste liquid from the reaction vessels 2 that have entered the first waste liquid extraction station 71 according to this cycle mode.
[0108] After the reaction vessel 2 enters the first liquid injection station 75, the first liquid injection assembly 31a injects a washing solution into the reaction vessel 2 to break up the magnetic beads, allowing the washing solution to fully contact the magnetic beads and separate and wash away the specimen and impurities. Next, the turntable 11 rotates, and the reaction vessel 2 passes through the first uniform mixing station 78, the second waste liquid removal station 72, the second liquid injection station 76, and the second uniform mixing station 79 in sequence. The first uniform mixing assembly uniformly mixes the cleaning liquid and magnetic beads in the reaction vessel 2 located at the first uniform mixing station 78, the second waste liquid extraction assembly 21b extracts the waste liquid after cleaning in the reaction vessel 2 located at the second waste liquid extraction station 72, the second liquid injection assembly 31b injects the cleaning liquid into the reaction vessel 2 located at the second liquid injection station 76, and the second uniform mixing assembly uniformly mixes the cleaning liquid and magnetic beads in the reaction vessel 2 located at the second uniform mixing station 79.
[0109] Then, the setting section 111a in the inner peripheral setting section group 111 on which the reaction vessel 2 is placed moves to the inner peripheral switching station 84, and the transfer device transfers the reaction vessel 2 to the setting section 111a located in the outer peripheral switching station 83 of the outer peripheral setting section group 112, and the reaction vessel 2, accompanied by the turntable 11, passes sequentially through the third waste liquid removal station 73, the third liquid injection station 77, the third uniform mixing station 81 and the fourth waste liquid removal station 74.
[0110] In addition, the operating methods of the second waste liquid extraction assembly 21b, the third waste liquid extraction assembly 21c, and the fourth waste liquid extraction assembly 21d are the same as the operating method of the first waste liquid extraction assembly 21a, the operating methods of the second liquid injection assembly 31b and the third liquid injection assembly 31c are the same as the operating method of the first liquid injection assembly 31a, and the operating methods of the second uniform mixing assembly and the third uniform mixing assembly are the same as the operating method of the first uniform mixing assembly. Therefore, here, the specific operating processes when the reaction vessel 2 is located at the second waste liquid extraction station 72, the second liquid injection station 76, the second uniform mixing station 79, the third liquid extraction station 73, the third liquid injection station 77, the third uniform mixing station 81, and the fourth liquid extraction station 74 will not be described in detail.
[0111] In the one-step method inspection and measurement item, the reaction vessel 2 from which the waste liquid has been extracted at the fourth waste liquid extraction station 74 is moved to the outer peripheral switching station 83, and then transferred from the outer peripheral switching station 83 to the measuring device for inspection and measurement.
[0112] In the case of an inspection or measurement item using the two-step method, the waste liquid is extracted at the fourth waste liquid extraction station 74, and after moving to the outer peripheral switching station 83, it is again transferred to the setting unit 111a located at the inner peripheral switching station 84 of the inner peripheral setting unit group 111. The reaction vessel 2 is then carried by the turntable 11 through the transfer station 86 to the sub-export station 85, i.e., the vessel loading station 82, and the transfer device transfers the reaction vessel 2 located at the sub-export station 85 back to the reaction apparatus. After the addition of the secondary reagent and the secondary reaction are completed, the reaction vessel 2 returns to the setting section 111a located at the vessel loading station 82, and repeatedly passes through the first waste liquid removal station 71, the first liquid injection station 75, the first uniform mixing station 78, the second waste liquid removal station 72, the second liquid injection station 76, the second uniform mixing station 79, the third waste liquid removal station 73, the third liquid injection station 77, the third uniform mixing station 81 and the fourth waste liquid removal station 74, before being transported out from the outer peripheral switching station 83.
[0113] By repeatedly extracting waste liquid and injecting liquid into the same reaction vessel 2, it is possible to separate and wash away the specimen and impurities, making it easier to inspect and measure the specimen thereafter.
[0114] During the entire cleaning process, different waste liquid extraction assemblies 21 extract waste liquid from the reaction vessels 2 located at their corresponding waste liquid extraction stations, different liquid injection assemblies 31 inject cleaning liquid into the reaction vessels 2 located at their corresponding liquid injection stations, and different uniform mixing assemblies uniformly mix the cleaning liquid and magnetic beads in the reaction vessels 2 located at their corresponding uniform mixing stations, all within the same time period. This allows the cleaning device 1 to simultaneously clean multiple reaction vessels 2 separately, resulting in high cleaning efficiency. The turntable 11 remains stationary while the waste liquid extraction assemblies 21 extract waste liquid and the liquid injection assemblies 31 inject cleaning liquid.
[0115] In the prior art, the turntable 11 is provided with only one set of mounting parts, and in order to increase the cleaning speed of the cleaning device 1, the residence time while the turntable 11 rotates intermittently is shortened. However, in order to ensure the cleaning effect, it is necessary to ensure that the time it takes for the reaction vessel 2 to pass through the magnetic attraction member is not changed, and the length of the magnetic attraction member installed in the circumferential direction of the turntable 11 must be increased. This inevitably increases the circumferential length of the turntable 11, and therefore the number of reaction vessels 2 that can be accommodated on the turntable 11 also increases, leading to an increase in the volume of the cleaning device 1 and an increase in the space occupied.
[0116] In contrast, in the present application, the turntable 11 is provided with multiple sets of setting sections for setting the reaction vessels 2. Therefore, during actual operation, the reaction vessels 2 accommodated in one set of setting sections can be distributed among multiple sets of setting sections, thereby reducing the number of reaction vessels 2 accommodated in each set of setting sections. This reduces the number of reaction vessels 2 accommodated in each set of setting sections, even when the speed of the turntable 11 is increased. Therefore, the time required for the reaction vessels 2 to pass through the magnetically attracted member can be ensured without increasing the length of the magnetically attracted member. In other words, even when the speed of the turntable 11 is increased, the time required for the reaction vessels 2 to pass through the magnetically attracted member can be ensured without increasing the length of the magnetically attracted member or the circumferential length of the turntable 11. This design reduces the volume and occupies less space in the cleaning device 1.
[0117] The technical features of the above-described embodiments can be combined in any manner. For the sake of brevity, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should all be considered to be within the scope described in this specification.
[0118] The above examples merely represent some embodiments of the present application, and although the description is specific and detailed, it should not be understood as limiting the scope of the patent application. It should be noted that those skilled in the art can make some modifications and improvements without departing from the concept of the present application, and all of these fall within the scope of protection of the present application. Therefore, the scope of protection of the present application should be determined based on the attached claims. [Explanation of symbols]
[0119] 1...cleaning device, 2...reaction vessel, 10...turntable mechanism, 20...waste liquid extraction mechanism, 30...liquid injection mechanism, 40...lifting mechanism, 50...magnetic attraction mechanism, 60...cleaning mechanism, 11...turntable, 111...set part group on inner periphery, 111a...set part, 112...set part group on outer periphery, 113...through hole group, 113a...through hole, 114...turntable motor, 115...turntable main driving wheel, 116...turntable driven wheel, 117...turntable timing belt, 118...mounting seat, 118a...center Hole, 21...waste liquid extraction assembly, 21a...first waste liquid extraction assembly, 21b...second waste liquid extraction assembly, 21c...third waste liquid extraction assembly, 21d...fourth waste liquid extraction assembly, 211...needle seat, 211a...seat body, 211b...shaft portion, 212...first waste liquid extraction needle, 213...second waste liquid extraction needle, 22...waste liquid extraction drive assembly, 221...waste liquid extraction seat, 222...waste liquid extraction motor, 223...waste liquid extraction main drive wheel, 224...waste liquid extraction timing belt, 225...waste Liquid extraction driven wheel, 226...tension wheel, 227...waste liquid extraction bearing, 228...waste liquid extraction bearing base, 31...liquid injection assembly, 31a...first liquid injection assembly, 31b...second liquid injection assembly, 31c...third liquid injection assembly, 41...lifting motor, 42...lifting main wheel, 43...lifting rack, 44...lifting rod, 51...first magnetic attraction member, 52...second magnetic attraction member, 53...third magnetic attraction member, 54...fourth magnetic attraction member, 61...cleaning assembly, 71...first waste liquid extraction station, 72 ...second waste liquid extraction station, 73...third waste liquid extraction station, 74...fourth waste liquid extraction station, 75...first liquid injection station, 76...second liquid injection station, 77...third liquid injection station, 78...first uniform mixing station, 79...second uniform mixing station, 81...third uniform mixing station, 82...container loading station, 83...outer peripheral switching station, 84...inner peripheral switching station, 85...sub-exit station, 86...transition station.
Claims
1. The apparatus includes a turntable (11) on which a plurality of setting portion groups for setting reaction vessels (2) are formed around the turntable (11), and all of the setting portion groups are arranged at intervals from the inside to the outside along the radial direction of the turntable (11), and at least one round of through-hole groups (113) is opened between two adjacent rounds of the setting portion groups, and all of the setting portions (111a) in the setting portion groups on each round and all of the through-holes (113a) in the through-hole groups (113) on each round are arranged at intervals along the circumferential direction of the turntable (11), A turntable mechanism characterized in that the set portion group on each periphery and the through-hole group (113) on each periphery are both provided concentrically with the turntable (11).
2. When the set portion group on one of the two adjacent circumferences is referred to as an inner set portion group (111) and the set portion group on the other circumference is referred to as an outer set portion group (112), the outer set portion group (112) is provided so as to surround the outer periphery of the inner set portion group (111), all the set portions (111 a) of the set portion group (111) on the inner periphery and all the set portions (111 a) of the set portion group (112) on the outer periphery correspond one-to-one in the radial direction of the turntable (11) and are arranged collinearly; 2. The turntable mechanism of claim 1, wherein each of the through holes (113a) of the through hole groups (113) on each periphery located between the inner peripheral set portion group (111) and the outer peripheral set portion group (112) corresponds to at least one of the set portions (111a) of the inner peripheral set portion group (111) in the radial direction of the turntable (11) within its own length along the circumferential direction of the turntable (11).
3. 3. The turntable mechanism of claim 2, wherein each of the through holes (113a) of the through hole groups (113) on each periphery located between the inner peripheral set portion group (111) and the outer peripheral set portion group (112) corresponds to at least two of the set portions (111a) of the inner peripheral set portion group (111) in the radial direction of the turntable (11) within a range of its length along the circumferential direction of the turntable (11).
4. 3. The turntable mechanism according to claim 2, wherein each of the through holes (113a) of the through hole groups (113) on each periphery located between the inner peripheral set portion group (111) and the outer peripheral set portion group (112) corresponds one-to-one with each of the set portions (111a) of the inner peripheral set portion group (111) in the radial direction of the turntable (11) and is arranged collinearly.
5. The turntable mechanism according to any one of claims 1 to 4, further comprising a turntable drive assembly, the turntable drive assembly including a turntable motor (114), a turntable main driving wheel (115), a turntable driven wheel (116), and a turntable timing belt (117), the turntable motor (114) being drivably connected to the turntable main driving wheel (115), the turntable timing belt (117) being wound around the outside of the turntable main driving wheel (115) and the turntable driven wheel (116), and the turntable driven wheel (116) being fixedly connected to the turntable (11).
6. A cleaning device comprising: The turntable mechanism of claim 1; a waste liquid extraction mechanism (20) including N (N≧2) sets of waste liquid extraction assemblies (21), each of which includes a waste liquid extraction needle; a liquid injection mechanism (30) including (N-1) liquid injection assemblies (31); the cleaning device has N waste liquid extraction stations, N cleaning stations, and (N-1) liquid injection stations, all of the waste liquid extraction stations and all of the cleaning stations correspond one-to-one to all of the waste liquid extraction assemblies (21), and all of the liquid injection stations correspond one-to-one to all of the liquid injection assemblies (31); the set groups on each periphery correspond to at least one set of the waste liquid extraction assemblies (21) and at least one set of the liquid injection assemblies (31), the set groups on different peripheries correspond to different waste liquid extraction assemblies (21) and different liquid injection assemblies (31), the through-hole groups (113) on each periphery correspond to at least one of the cleaning stations, and the through-hole groups (113) on different peripheries correspond to different cleaning stations; The cleaning device is characterized in that the waste liquid removal stations and the liquid injection stations are provided alternately along the rotation direction of the turntable (11).
7. the cleaning device further includes N first switching stations and N second switching stations, all of the first switching stations and all of the second switching stations are located on the top side of the turntable (11), all of the first switching stations and all of the second switching stations correspond one-to-one to all of the waste liquid extraction assemblies (21), the first switching stations and the waste liquid extraction stations corresponding to the same waste liquid extraction assembly (21), and the second switching stations and the cleaning stations corresponding to the same waste liquid extraction assembly (21) are aligned in the axial direction of the turntable (11), the waste liquid extraction assemblies (21) are moved under control, and the waste liquid extraction needles thereof are switched between the corresponding first switching stations and the second switching stations; The cleaning device further includes a lifting mechanism (40) that is connected to the waste liquid removal mechanism (20) and drives the waste liquid removal mechanism (20) to lift and lower the turntable (11) in the axial direction, During the process of the waste liquid extraction mechanism (20) rising, the waste liquid extraction needle of the waste liquid extraction assembly (21) moves from the corresponding waste liquid extraction station to the corresponding first switching station, or moves from the corresponding washing station to the corresponding second switching station; 7. The cleaning device of claim 6, wherein, during the process of the waste liquid extraction mechanism (20) descending, the waste liquid extraction needle of the waste liquid extraction assembly (21) moves from the corresponding first switching station to the corresponding waste liquid extraction station, or moves from the corresponding second switching station to the corresponding cleaning station.
8. 8. The cleaning device of claim 7, wherein the waste liquid extraction mechanism (20) further includes a waste liquid extraction drive assembly (22), which is transmission-connected to all of the waste liquid extraction assemblies (21) and synchronously drives all of the waste liquid extraction assemblies (21) to rotate or translate, thereby switching the waste liquid extraction needles of the waste liquid extraction assemblies (21) between the corresponding first switching station and the second switching station.
9. The set portion group has two circumferences, including an inner circumference set portion group (111) and an outer circumference set portion group (112), The cleaning device includes an inner peripheral switching station (84) provided on a rotation path of the inner peripheral set unit group (111) and located downstream of all of the waste liquid removal stations and all of the liquid injection stations corresponding to the inner peripheral set unit group (111), and an outer peripheral switching station (83) provided on a rotation path of the outer peripheral set unit group (112) and located upstream of all of the waste liquid removal stations and all of the liquid injection stations corresponding to the outer peripheral set unit group (112), The cleaning device according to claim 6, characterized in that, when the reaction vessel (2) located in the inner peripheral set unit group (111) has completed all waste liquid extraction and all liquid injection operations corresponding to the inner peripheral set unit group (111) in the inner peripheral set unit group (111) and moved to the inner peripheral switching station (84), it is transferred from the inner peripheral switching station (84) to the set unit (111a) of the outer peripheral set unit group (112) located in the outer peripheral switching station (83), and the waste liquid extraction and liquid injection operations corresponding to the outer peripheral set unit group (112) are continued in the outer peripheral set unit group (112).
10. 10. The cleaning device according to claim 9, wherein the inner peripheral changeover station (84) and the outer peripheral changeover station (83) are provided along the same radial direction of the turntable (11).
11. The cleaning device has a container carry-in station (82) and a sub-carry-out station (85), both of which are provided on a rotation path of the inner peripheral set unit group (111), the container carry-in station (82) being located upstream of all of the waste liquid removal stations and all of the liquid injection stations corresponding to the inner peripheral set unit group (111), and the sub-carry-out station (85) being located downstream of all of the waste liquid removal stations and all of the liquid injection stations corresponding to the inner peripheral set unit group (111), The cleaning device described in claim 9 or 10, characterized in that the container loading station (82) is used to receive reaction containers (2) transferred from a reaction apparatus, and when all waste liquid removal and all liquid injection operations corresponding to the outer peripheral set section group (112) are completed in the outer peripheral set section group (112) and the reaction containers (2) move to the outer peripheral switching station (83), the reaction containers (2) are transferred from the outer peripheral switching station (83) through the inner peripheral switching station (84) to the sub-export station (85), and are transferred from the sub-export station (85) to the reaction apparatus.
12. 12. The cleaning apparatus according to claim 11, wherein the sub-exit station (85) overlaps with the container input station (82).
13. The cleaning device further includes a transfer station (86) provided on a rotation path of the set unit group (111) on the inner periphery and positioned between the switching station (84) on the inner periphery and the sub-discharge station (85), When the outer peripheral set unit group (112) has completed all waste liquid extraction and all liquid injection operations corresponding to the outer peripheral set unit group (112) and moved to the outer peripheral switching station (83), the reaction vessel (2) is transferred from the outer peripheral switching station (83) to the inner peripheral switching station (84), and then moved to the sub-discharge station (85) via the transfer station (86); 12. The cleaning device according to claim 11, wherein when the reaction vessel (2) is located at the transfer station (86), the cleaning device is only used to transport the reaction vessel (2).
14. A sample analyzer comprising the cleaning device according to claim 6.
Citation Information
Patent Citations
Reaction container structure body for automatic analyzing device
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