Herbal prescriptions to treat hives, eczema, and hypersensitivity / allergies

Abstract

Provided is a Chinese herbal composition for treating urticaria, eczema, and hypersensitivity / allergy, which is Chinese herbal formula I, Chinese herbal formula II, or a mixed prescription thereof, and the ingredients of Chinese herbal formula I are Scutellaria Root, Coptis Rhizome, Forsythia Suspensa, Perilla Leaf, Magnolia Magnolia, White Atractylodes Root, Angelica Root, Radix Paeoniae Radix, Scutellaria Baicalensis, Scutellaria Baicalensis, White Grass, Green Alder, Anemone Rhizome, and Acanthus Officinalis Root. The ingredients in Chinese herbal prescription II are extracts of licorice, mint, Cnidium Root, Salvia Officinalis, Purple Shepherd's Ding Dong, and Daqing Leaf, and the ingredients in Chinese herbal prescription II are licorice, mint, Cnidium Root, Rhus Root, Kojyu, Dandelion, Rhubarb, Qianli Guang, ginger, Goldenrod, Zoysia Root, Euonymus Root, Euonymus Root, White Head Wing, Peony Pea, Magnolia, Cornus Officinalis, Cuckoo Root, Chinese Coptis, White Fresh Skin, Jing Ge, and Chrysanthemum Root.

Description

[Technical field]

[0001] Medicine: Dermatology / Allergy, Chinese Medicine / Chinese Herbal Medicine, Microbiology. [Background technology]

[0002] The root cause of urticaria, eczema, and hypersensitive (allergic) constitution disease has not been concluded in the medical community worldwide.In Western medicine, the main treatment for this disease is to intervene in the process of allergy development, and antihistamines, immunomodulators (such as omalizumab) and hormonal drugs (such as dexamethasone, hydrocortisone) are widely used, among which antihistamines are the most widely used.This treatment method has a significant therapeutic effect in controlling the skin symptoms of acute urticaria and acute eczema, but for patients with hypersensitive (allergic) constitution and chronic urticaria and chronic eczema, it can only control symptoms but cannot be cured, and the cured acute urticaria and acute eczema patients cannot eradicate the root cause of hypersensitivity development, and there is a risk of acute urticaria and acute eczema being transformed into chronic urticaria, chronic eczema, and hypersensitive constitution. In traditional Chinese medicine, the treatment of urticaria and eczema has the advantage of treating the disease itself and treating the pathogen at the same time. Healed acute urticaria (acute eczema) is basically unlikely to turn into chronic urticaria (chronic eczema). In particular, the treatment effect of traditional Chinese medicine in treating chronic urticaria, chronic eczema and hypersensitive (allergic) constitution is remarkable, and the drug resistance period that can control symptoms is long, and it has the potential to cure chronic urticaria, chronic eczema and hypersensitive (allergic) constitution. However, unfortunately, the prevalence and frequency of use of traditional Chinese medicine in the treatment of urticaria, eczema and hypersensitive is much lower than that of antihistamines. And traditional Chinese medicine understands urticaria, eczema and hypersensitive as "wheals", "cold" and "exema", and the recognition of the cause is unclear. If this is used as the theoretical basis for treatment, it is difficult to achieve the goal of healing. Summary of the Invention [Problem to be solved by the invention]

[0003] From 2010 to September 2015, during the continuous treatment of the patient's family-contagious chronic spontaneous severe urticaria (hypersensitive constitution), he successively took oral medications such as Skin Disease Blood Decoction Pill - Tongren Tang, Yubyobu Capsules, Junxing Antipruritic Capsules, Baizhan Xiata Repellent Sheets, Baizhen Granules, Loratadine Tablets, Desloratadine Dispersible Tablets, Couderatadine Tablets, Cetirizine, Levocetirizine Hydrochloride, Cimetidine Tablets, Chlorpheniramine, Ketotifen, Prednisone Tablets, Complex Vitamin B Tablets, etc. for the skin rash. Topical medications such as samethasone ointment, paeonol ointment, and ruganshi decoction were applied externally, and the above oral medications were all used in combination with other treatment methods, among which the combination of Dermatitis Blood Decoction Pills + Kuderatadine tablets (or desloratadine dispersible tablets) + levocetirizine dihydrochloride tablets, and the combination of Baizhan Xiata Repean + Kuderatadine tablets (or desloratadine dispersible tablets) + levocetirizine hydrochloride tablets were most effective. During the course of treatment, the patient's severe chronic spontaneous urticaria (hypersensitive constitution) symptoms were alleviated to a certain extent, but not cured, and the effect of controlling the symptoms was increasingly worse.

[0004] During the past 5 years of continuous treatment process of chronic spontaneous urticaria (hypersensitive constitution), the author found that Chinese herbal medicines: Tongrentang Skin Disease Blood Decoction Pill and Baizhan Xiata Repian play a decisive role in treating comorbid diseases such as skin itching, bloodshot and itchy eyes, scrotum itching, stomatitis, ear canal itching, chronic digestive system and chronic nervous system diseases. Therefore, he started to try Chinese herbal prescriptions for treatment from September 2015, and started to use the Chinese herbal granule prescription after November 2015. Up until November 2018, the types of herbal medicines (granules) used included: Gyokubeisu, Jikoppi, Boukon, Anemone Rhizome, Dobukuryou, (wheat) fried white atractylodes, Scutellaria Root, White alder, Scutellaria Root, Sophora Root, Boufu, Scutellaria Root, Lotus Leaf, White Fresh Skin, Goldenrod, Lithospermum, Mulberry Leaf, (wheat) fried coix seed, Sajiomozu, Doukou, Chrysanthemum Root, Dioscorea Root, Shazensou, There are more than 40 kinds of herbal medicines, such as (salt) psyllium saplings, Salvia miltiorrhiza, Scutellaria baicalensis, Peony root, Cinnamon bark, Pearl ginseng, Gardenia frutescens, Red peony root, Cicada retreat, Polygala serrata, Roasted gypsum, Roasted chicken buds, Chinese rhizome, (fresh) Gemstones, Gurnard, Motif, Atractylodes arvensis, Rhizome, Angelica acutiloba, Licorice, Roasted burdock, etc. Each herbal medicine prescription is composed of 12 to 19 kinds of types. The herbal medicine prescription can control the chronic spontaneous urticaria symptoms of the patient again, and gradually further improve the patient's hypersensitive constitution. From April to May 2016, the patient took the Chinese herbal medicine urticaria pills and at the same time received one injection of injectable thymopentin each month to adjust the body's immune system. Compared with taking the Chinese herbal medicine granules, the therapeutic effect was not significant and the patient experienced severe discomfort in the digestive tract after taking the urticaria pills. After two months of use, the patient discontinued the treatment.

[0005] After December 2018, new varieties of Chinese herbal medicines (granules) were tried, and the original commonly used varieties were found to be less effective or less effective in controlling persistent complications such as anti-itching, anti-irritation, bloodshot and itchy eyes, scrotal itching, stomatitis, itching in the ear canal, chronic digestive system and chronic nervous system diseases. Up until March 2022, the types of herbal medicines (granules) that were newly used included: roasted budworm kernel, dried ginger, jiang huang, chenpi, roasted kyosan, (nectar) ephedra, buping, cnidium rhizome, scutellaria, purple crocus, soukakushi, white angelica, hominyōto, dokkatsu, forsythia, white pepper, (ginger) magnolia, magnolia flower, kōjū, chōren, kochōren, celery pollen, roasted jellyfish, dandelion, (roasted) shizurishi, taisei, (roasted) white mustard, bellflower, (vinegar) schisandra zirconia, ume plum, bupleurum chinense, silver hawthorn, (made) polyhedron, canna, iuca There are more than 50 kinds of herbal medicine granules, including licorice, (salted) Eucommia Root, Kyokatsu Root, Atractylodes Ferment, Gypsophila Root, Green Loosestrife, Mint, Perilla Leaf, Cotton Horsetail Root, Archeros Root, Chinese Cabbage, Magnolia Root, Poria Coix, Chinese Cabbage, Stone Herb, Snakestrife, Clove Fragrance, Cornus Officinalis, ginger, Cuckoo Root, (ripe) Rhubarb, Qianli Guang, and Baek Tou Weng. At the same time, the previous types of herbal medicine granules: licorice, (salted) Anemone Rhizome, Peony Root, (wheat) Roasted Atractylodes Root, Scutellaria Root, Sophora Root, Jingxiang, Saxifraga Root, Cinnamon Bark, Mulberry Leaf, Salvia Officinalis, Red Peony Root, White Pearl, Scutellaria Root, Golden Rooster, (roasted) Burdock Fruit, Chrysanthemum Root, and Ground Pepper, etc. were still used.

[0006] With reference to the prescriptions, typical prescriptions, and herbal medicine types used or recommended by many Chinese medical experts in China, a total of nearly 100 kinds of herbal medicines have been screened, and through repeated testing by the person himself, prescriptions have been drawn up from 3 to 4 types (equivalent to about 90g to 110g of finely ground herbal materials for decoction), to 18 to 21 types (equivalent to about 180g to 210g of finely ground herbal materials for decoction), to finally 26 types (equivalent to about 260g of finely ground herbal materials for decoction), and thus more than 30 types of medicinal plants with significant therapeutic effects have been obtained, of which 18 to 20 types (equivalent to about 180g to 200g of finely ground herbal materials for decoction) have been taken to form the herbal medicine prescriptions, which have the best therapeutic effect and relatively minimal side effects. As of March 2022, the patient's family-contagious severe chronic spontaneous urticaria (hypersensitive constitution) had already been completely cured.

[0007] The author has found through more than 10 years of continuous treatment of familial contagious, cold-type, and chronic spontaneous urticaria from the treatment methods and results that the fundamental cause of hypersensitive (allergic) constitution, urticaria, and eczema is that microorganisms such as bacteria, fungi, and viruses invade the body, adapt, survive, and reproduce in large numbers inside the host's body, competing with the host for nutrients, destroying the host's tissues, organs, and nerve units, and at the same time, the toxic substances metabolized and excreted into the host's body fluids further damage the host's tissues, organs, and nerve units, thus continuously causing hypersensitive reactions in the host's body, severe itching, and various complications.

[0008] When the infected parasitic microorganism is one or two kinds and reproduces in large quantities within a short time, the host will be described as sudden acute urticaria (or acute eczema). When the infected parasitic microorganism is multiple kinds and invades the host body in different periods, adapts, survives, and gradually reproduces in large quantities, the host body will be described as hypersensitive (allergic) constitution, chronic urticaria, and chronic eczema, so the fundamental means of treating hypersensitive, urticaria, and eczema is antimicrobial, which inhibits the growth and reproduction, kills the pathogen, and purifies the host's body fluids. Although it is difficult to know the category of the type of parasitic pathogenic microorganism, many broad-spectrum antibacterial drugs in Chinese medicine have various inhibitory, resisting, and even killing roles against many types of microorganisms, so the disease can be treated accordingly using the form of Chinese medicine antibacterial prescription. In traditional Chinese medicine, the treatment method of clearing heat and detoxifying and using it in the treatment of hypersensitive constitution, chronic urticaria and chronic eczema has a remarkable therapeutic effect, because it realizes antibacterial effect and anti-inflammatory effect. However, in traditional Chinese medicine, hypersensitive constitution is understood as "cold", "wheal" and "exema", and the microorganisms that induce hypersensitive constitution are huge in number and have strong mutation ability, so the recognition of anti-drug properties in the treatment process is not clear, there is no accurate treatment concept in the essence of guidance, and it is difficult to maintain effective treatment methods in practice, so it is difficult to cure hypersensitive constitution, chronic urticaria and chronic eczema. [Means for solving the problem]

[0009] Factors that induce hives, eczema, and hypersensitivity (allergy) due to tumors, serious liver and kidney diseases, and thyroid diseases are eliminated. By analyzing the cause and symptoms, it is diagnosed as hives (without classifying them into types), hypersensitivity, and eczema.

[0010] For those with long-term digestive and nervous system diseases with symptoms such as diarrhea, chronic pharyngitis, stomatitis ulcers, chronic (ulcerative) intestinal gastritis, anal itching, genital itching, poor quality of sleep, neurasthenia, mental excitement, fatigue, etc., the following Chinese herbal prescription can be used: 10g of licorice, 6g of mint, 10g of Dandelion, 10g of roasted white atractylodes, 10g of daisy fruit, 10g of Scutellaria baicalensis, 6g of Coptis Rhizome, 10g of Forsythia Root, 10g of perilla leaf, 10g of Asclepias Root, 10g of White Root, 12g of Pearl Millet, 10g of Cotton Horse Radix, 12g of Anemone Rhizome, 10g of White Fresh Skin, 10g of Angelica Root, 10g of Dandelion, 10g of Clove Fragrance, 10g of Cornus Officinalis, and 15g of Purple Earth Clover. Taking this formula can control itching and systemic hypersensitivity reactions, relieve diarrhea, and relieve mental agitation caused by systemic hypersensitivity or itching, while also helping to ensure high-quality sleep at night, and the formula essentially does not produce tolerance when used continuously for a year.

[0011] For people with long-term respiratory and nervous system diseases such as allergic rhinitis, allergic bronchitis / asthma, poor quality of sleep, nervous exhaustion, mental excitement, and fatigue, select medicines with antibacterial, antiallergic, sedative, and immune system regulation effects. For example, licorice 10g, mint 12g, red sage 10g, gentian 6g, ginger 15g, scutellaria baicalensis 10g, Coptis Rhizome 6g, forsythia 10g, perilla leaf 10g, ginger and magnolia. The prescription is made up of 12g of Heavenly Flower 15g, 15g of Thousand Li Guang, 12g of Scutellaria Root, 10g of Goldfinch, 15g of Bighorn Leaf, 6g of Matured Rhubarb, 3g of Coptis Rhizome, 10g of Ginger, and 10g of Cuckoo Root. Taking this prescription can control itching and hypersensitivity reactions, suppress allergic rhinitis, allergic bronchitis / asthma, relieve mental excitement caused by general hypersensitivity or itching, and at the same time help you get a high-quality night's sleep.

[0012] For those with respiratory, digestive and nervous system disorders such as chronic conjunctivitis, chronic pharyngitis, stomatitis / ulcers, chronic (ulcerative) gastrointestinal inflammation, anal itching, genital itching, allergic rhinitis, allergic bronchitis / asthma, poor quality of sleep, neurasthenia, mental excitement and fatigue, take 3-9g of Scutellaria Root, 1.5-8g of Coptis Rhizome, 6-15g of Forsythia Root, 3-10g of Magnolia Root, 10-30g of Purple Groundnut, 3-15g of Roasted Atractylodes Root, 3-10g of Angelica Root, 5-12g (15-30g) of Pearl Bark, 6-12g of Anemone Rhizome, 9-15g of Heavenly Pollen, 10g of Licorice Root, 6-30g of Roasted Bitter Melon Fruit, 3-10g of White Grassroot, 5-10g of Perilla Root, 5-10g of Scutellaria Baicalensis, 5-12g of Scutellaria Baicalensis, 5-12g of Scutellaria Baicalensis, 5-12g of Scutellaria Baicalensis, 5-12g of Scutellaria Baicalensis, 5-15g of Scutellaria Baicalensis, 5-10 ... 3~9g, Aoba 6~15g (20~40g), Aoba 10~15g, Wataba Kanshu 5~15g, Danshen 5~15g, Mentha 3~6g, Senrikou 15~ 30g, Baekduo 15~30g, Koju 3~9g, Gamakoei 10~30g (60g), Kingfisher 10~20g, Shoten 5~10g, Botanpi 6~ You can choose from the following types of herbal medicines: Magnolia Root 3-10g, Rhubarb 3-12g, Ginger 3-10g, Atractylodes Fruit 3-6g, White Fresh Peel 6-15g, Cornus Officinalis Root 5-10g, Chrysanthemum Root 10-15g, Cnidium Root 3-10g, Gentian 3-6g, Scutellaria Root 3-10g, Chinese Coptis Rhizome 6-12g, and Cuckoo Root 6-10g. Effect of the Invention

[0013] In the case of acute urticaria, sudden severe hypersensitivity, such as anaphylactic shock, laryngeal edema, hypertension, hypotension, fainting, etc., the hypersensitivity symptoms should first be controlled, and then the allergens should be eradicated using Chinese herbal prescriptions: second-generation antihistamines should be combined with Chinese herbal prescriptions, or systematically and stepwise combined with glucocorticoids + second-generation antihistamines + Chinese herbal prescriptions, or systematically and stepwise combined with adrenaline + second-generation antihistamines + Chinese herbal prescriptions. [Brief description of the drawings]

[0014] [Figure 1] Patient 1: Familial (hereditary) chronic spontaneous urticaria, male, 39 years old. [Diagram 2] Patient 3: Chronic spontaneous urticaria, male, 47 years old. [Diagram 3]Patient 4: Familial contagious (hereditary) chronic spontaneous urticaria, female, aged 60 years. [Figure 4] Patient 5: Acquired chronic spontaneous eczema, female, 35 years old. [Diagram 5] Patient 6: Familial contagious (hereditary) chronic spontaneous eczema. Photograph of a 12-year-old boy. [Figure 6] Patient 7: Acquired chronic spontaneous urticaria (severe dermatographia), hand eczema, male, 40 years old. [Figure 7] Patient 11: Female, 60 years old, with chronic spontaneous urticaria. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0015] Best Mode for Carrying Out the Invention Ingredients of Chinese herbal prescription I: Scientific extracts of 20 kinds of Chinese herbal medicines including Scutellaria Root, Coptis Rhizome, Forsythia Suspensa, Perilla Leaf, Magnolia Magnolia, White Atractylodes Root, Angelica Root, White Peony Root, Bianthus Fruit, Scutellaria Baicalensis Root, White Lovage Rhizome, Anemone Rhizome, Heavenly Pollen, Licorice, Mint, Mentha Root, Salvia Scutellaria, Red Sage, Purple Ding Ding, and Bighorn Leaf. The content of each ingredient is: Scutellaria Root 9g~10g, Coptis Rhizome 6~8g, Forsythia Root 10~12g, Perilla Leaf 10g, Ginger Magnolia Root 10~12g, Roasted Atractylodes Macrocarpa 10g, Angelica Root 10~12g, Radix Paeonia L. Root 10~12g, Roasted Berry Seed 10~15g, Scutellaria Root 9~12g, White Root 10g, Green Lovage Rhizome 10~12g, Anemone Rhizome 10~12g, Heavenly Pollen 10~12g, Licorice Root 9~10g, Mint Root 6~12g, Cottonseed Root 10~12g, Salvia Salicaria Root 8~10g, Purple Ding Ding Cing Root 10~15g, and Big Blue Leaf 10~15g. The scientific extracts of these 20 ingredients are used to make Chinese herbal prescription I, which is then made into oral medications such as oral pills, powders or capsules; at the same time, the extracts of these 20 ingredients are used to make topical medications such as external medicinal solutions, plasters or medicated patches, which are then used in conjunction with the oral medication to be applied to areas of severe itching on the skin, for external use, etc.

[0016] When this prescription is taken orally and applied topically, it can rapidly control various urticaria, various eczema, hypersensitivity / allergy symptoms and many severe skin itching of unknown causes, and when administered continuously, it can thoroughly cure the above symptoms. When taking this prescription orally in the early stage, if urticaria, eczema, hypersensitivity and aggravation of skin itching occur, antihistamines can be taken orally at the same time, so as to achieve the purpose of treating the disease itself and treating the pathogen at the same time.

[0017] EMBODIMENTS OF THE PRESENTINVENTION Chinese herbal formula II: 21 kinds of Chinese herbal active ingredients, namely, licorice, mint, rhubarb, goju, dandelion, Qianli Guang, Baektoush, magnolia, scutellaria, cnidium, silverleaf, scutellaria, ginger, peony root, white fresh skin, chrysanthemum, scutellaria, Chinese laurel, cuckoo vine, and Chinese quince, are scientifically extracted. The content of the above 21 ingredients is: licorice 9-10g, mint 6-12g, Qianli Guang 15-20g, Baektoush 15-20g, goju 9-10g, dandelion 10-15g, silverleaf 10-15g, scutellaria 9-10g, peony root 9-10g, scutellaria, Chinese quince ... scutellaria, The effective ingredients are scientifically extracted to form Chinese herbal prescription II, which is made into oral pills or capsules. At the same time, the scientific extracts of each ingredient are used to form Chinese herbal prescription II to make an ointment or ointment, which is used in conjunction with the oral medication to apply to areas of severe itching on the skin.

[0018] When this prescription is taken orally and applied topically, it can quickly control various urticaria, various eczema, hypersensitivity / allergy symptoms and many severe skin itching of unknown causes, and when administered continuously, it can completely cure these diseases. When taking this prescription orally in the early stage, if urticaria, eczema, hypersensitivity and aggravation of skin itching occur, antihistamines can be taken orally at the same time, so as to achieve the purpose of treating the disease itself and treating the pathogen at the same time.

[0019] Industrial utility The invention treats various acute and chronic urticaria, acute and chronic eczema, hypersensitivity / allergy, allergic conjunctivitis, chronic pharyngitis, allergic rhinitis / sinusitis, allergic bronchitis / asthma, oral suppurative infection, sticky / thick tongue coating, severe bad breath, chronic (ulcerative) intestinal gastritis, colitis, proctitis, concurrent joint and muscle pain, fatigue, concurrent ear canal itching, genital itching, scrotal itching, anal pain and itching, bloodshot eyes and itching, etc., comorbidities such as poor quality of sleep, biological clock / endocrine disorder, cranial nerve weakness, comorbidities such as mental lethargy / excitement and alternation, and microbial infections such as influenza virus, scabies mites, Helicobacter pylori, Mycoplasma pneumoniae, diarrheal bacillus, various psoriasis fungi, etc. EXAMPLES

[0020] Working Example Patient 1: Familial (hereditary) chronic spontaneous urticaria, male, 39 years old.

[0021] The patient's grandfather had severe urticaria and suffered from severe itching all over his body. When the urticaria on his thighs attacked him, he would burn them to relieve the itching. The patient had suffered from severe scrotal itching and skin itching since childhood. From the age of 7 to 10, large areas of roseola appeared on both arms and under the shoulders and armpits every year. The itching was severe. After that, the rash did not recur on the arms and armpits. Erythema appeared at various times and in various places all over the body, with attacks being particularly frequent and severe in the central back, lower back, inner upper thighs and scrotum. As the patient grew older, the erythema and severe itching became more and more severe. The patient's body began to develop chronic enteritis such as ulcerative proctitis and colitis, and he had suffered from diarrhea for many years and repeated colds for many years, which were difficult to cure. At the same time, he was accompanied by a series of problems such as serious sleep problems, endocrine disorder, brain and nerve weakness, mental excitement and mental decline and their alternation, chronic conjunctivitis, chronic pharyngitis, ear canal itching, and allergic rhinitis.

[0022] From 2010 to September 2015, the patient successively took oral medications such as Tongrentang Skin Disease Blood Poison Pills, Yubyofu Capsules, Wenxing Anti-Itching Capsules, Baizhan Xiata Retardant Tablets, Baizhen Granules, loratadine tablets, desloratadine dispersible tablets, cuderoratadine tablets, cetirizine, levocetirizine hydrochloride, cimetidine tablets, chlorpheniramine, ketotifen, prednisone tablets, and complex vitamin B tablets. At the same time, the patient used topical medications such as fluocinonide ointment, triamcinolone acetate acetonide cream, dexamethasone ointment, paeonol ointment, and Luoganshi wash for the skin rash. All of the above oral medications were used in combination treatment, such as cuderoratadine tablets + levocetirizine tablets + wenxing anti-itch capsules at the same time, and cuderoratadine tablets + Skin Disease Blood Poison Pills at the same time. In the 5-6 years of treatment with this method, the control effect is relatively good in the early stage, and the severe chronic spontaneous urticaria (hypersensitive constitution) symptoms are alleviated to a certain extent, but the skin itching and other comorbid symptoms cannot be completely controlled throughout, and the chronic urticaria cannot be cured, and the effect of controlling symptoms is getting worse and worse.In this treatment process, it is found that the Chinese herbal medicines Tongren Tang Xuedu Wan and Baizhan Xiata Repian play a decisive role in controlling urticaria symptoms and improving hypersensitive constitution.

[0023] From November 2015 to May 2022, the patient's severe chronic spontaneous urticaria was treated with a Chinese herbal medicine granule prescription. By referring to the prescriptions used or recommended by many Chinese medicine experts in China, typical prescriptions, and Chinese herbal medicine types, a total of nearly 100 kinds of Chinese herbal medicines were screened and repeatedly tested, from 3 to 4 types of prescriptions (equivalent to approximately 90g to 110g of finely ground medicinal materials for decoction), to 18 to 21 types of prescriptions (equivalent to approximately 180g to 210g of finely ground medicinal materials for decoction), and finally to 26 types of prescriptions (equivalent to approximately 260g of finely ground medicinal materials for decoction), and thereby more than 30 types of medicinal plants with significant therapeutic effects were obtained, and Chinese herbal medicine prescription I and Chinese herbal medicine prescription II with the best therapeutic effect and relatively minimal side effects were composed. Using Chinese herbal prescription I and Chinese herbal prescription II (or some of the ingredients of the two prescriptions are crossed and exchanged), from January 2021, after more than a year of continuous treatment, the patient's whole body skin erythema and roseola have all disappeared, and in February 2022, before the patient was cured, except for the sudden outbreak of severe roseola and itching in both arms (a rebound symptom before recovery that had not appeared again for more than 20 years), the whole body no longer had itching. With the disappearance of the skin symptoms, the patient's chronic enteritis: ulcerative proctitis, colitis, hemorrhoids, sleep quality problems, endocrine disruption problems, constant mental atrophy, mental excitement and alternation, whole body muscle, joint habitual pain, semi-healthy repeated colds, chronic pharyngitis, chronic conjunctivitis, allergic rhinitis, ear canal itching, and other series of hypersensitive constitution-related diseases have all disappeared or disappeared, and the hypersensitive constitution problem has almost been resolved.

[0024] A typical skin rash healing process is shown in Patient 1 of the accompanying drawings.

[0025] Patient 2: Familial (hereditary) chronic spontaneous urticaria, female, 54 years old.

[0026] The sister of the father of Patient 1, the patient had been suffering from severe itching since childhood and had been receiving treatment for more than 50 years. The urticaria symptoms had been present for many years. When itching occurred, dark red scratches appeared at the scratched area, and the itching was severe and difficult to relieve. After itching, the skin returned to normal, and the symptoms worsened in autumn and winter. It was diagnosed as familial contagious severe spontaneous cold-type urticaria.

[0027] In February 2014, the patient took the Chinese herbal medicine Tongren Tang, and occasionally took levocetirizine hydrochloride tablets and desloratadine dispersible tablets at the same time to control the hypersensitivity symptoms. The treatment course was more than half a year, and the treatment effect was significant. The skin itching symptoms were greatly improved, but not eradicated. In February 2021, after the recurrence of urticaria, patient 1 took two commonly used Chinese herbal prescriptions, namely prescription I and prescription II (granule preparation prescription), of which prescription I removed Scutellaria Baicalensis, Forsythia Suspensa, and Mianma Guanzhu, and prescription II removed Qianli Guang, Baitou Weng, Magnolia Yew, Euonymus Root, Cinnamon, Cornus Officinalis, and Gentian, and added Scutellaria Baicalensis, Forsythia Suspensa, Cinnamon Bark, Sophora Root, and Roasted Burdock. The two prescriptions were each five sets, one set was taken daily, fully dissolved in 300ml of cooled boiled water, and half was taken in the morning and evening. When each prescription was taken orally, all of them could control the urticaria symptoms. After taking 10 sets of the medicine, the recurrent urticaria symptoms completely disappeared. Five days after the drug was stopped, the patient was re-examined, and the urticaria symptoms did not reappear. Ten days after the drug was stopped, the weather in the patient's location suddenly became cold and there was heavy snowfall, and the patient was re-visited, and there was no itching sensation when sleeping at night. Twenty days after the drug was stopped, the patient was re-examined, and the urticaria symptoms did not reappear. It was provisionally determined that the patient's urticaria was basically cured.

[0028] Patient 3: Chronic spontaneous urticaria, male, 47 years old.

[0029] From July and August 2021, the patient suffered from attacks of severe urticaria without any obvious trigger, erythema all over the body, roseola on the palms, and some erythema covering a large area. The patient was suffering from severe itching, chronic gastrointestinal diseases, stomach distension and intermittent attacks of severe pain, abdominal pain accompanied by diarrhea, scrotal itching, anal itching and pain, and symptoms of internal and external hemorrhoids. Pus sacs were observed around the oral cavity. At night, the patient had severe skin itching, poor sleep quality, and loss of appetite. Since October 2021, the patient has been receiving treatment at Bengbu City Third People's Hospital. He was diagnosed with "acute urticaria" during outpatient consultation. He was administered 80-120 mg of injectable methylprednisolone sodium succinate (40 mg / bottle) intravenous drip infusion for anti-inflammatory effects, took desloratadine and ebastine tablets for anti-hypersensitivity effects, and took mosapride citrate tablets and rabeprazole sodium tablets to protect the stomach. As the disease could not be controlled throughout the course of the hospitalization, the patient was hospitalized for treatment on October 10, 2021. During the hospitalization, the patient was administered 40 mg of injectable methylprednisolone sodium succinate (40 mg / bottle) once a day for anti-inflammatory effects, 3 g of vitamin C (1 g / bottle) once a day, calcium gluconate (10 ml: 1 g), and 200 mg of cimetidine injection (2 ml: 0.2 g / bottle) once a day by intravenous drip infusion. At the same time, the patient was administered cudolatadine tablets, ebastine tablets, and ketotifen fumarate tablets for anti-hypersensitivity effects, and mosapride citrate tablets and rabeprazole sodium tablets for stomach protection. Paeonol ointment and triamcinolone acetonide econazole cream were applied to the skin rash in succession. By October 28, when he was discharged from the hospital, the severe itching all over his body had eased, and the generalized erythema on his trunk and limbs had significantly decreased compared to when he was admitted, but the itching all over his body was still obvious, his nighttime sleep quality and appetite were still poor, and he still needed to receive daily intravenous drip infusions of methylprednisolone sodium succinate for injection, vitamin C, etc. for anti-inflammatory effects, and at the same time, he needed to take cudolatadine tablets and ebastine tablets for anti-hypersensitivity effects, and mosapride citrate tablets or rabeprazole sodium tablets to protect his stomach, which could alleviate the intermittent attacks of severe pain in his stomach and anus.

[0030] From January 19, 2022, the patient was given 40 mg of injectable methylprednisolone sodium succinate (40 mg / bottle) once a day for anti-inflammatory effects, 3 g of vitamin C (1 g / bottle) once a day by intravenous drip, and took antihistamines and stomachic drugs orally, and then started taking a set of Chinese herbal medicines orally every day. For antihistamines, the patient successively used cudeloratadine tablets, ebastine tablets, olopatadine hydrochloride tablets, and ranitidine hydrochloride capsules; for stomachic drugs, the patient successively used mosapride citrate tablets, rabeprazole sodium tablets, and omeprazole magnesium enteric-coated tablets; for Chinese herbal medicine prescriptions, the patient successively used Chinese herbal medicine prescription I, Chinese herbal medicine prescription II, and a mixed prescription of prescription I and prescription II. On January 29, 2022, the intravenous injection was stopped, and the hormones prednisone tablets and dexamethasone tablets were added successively for anti-inflammatory effects. On February 15th, the patient stopped taking hormones, took Chinese herbal prescription for comprehensive antibacterial effect, olopatadine hydrochloride tablets for antihistamine, and omeprazole magnesium enteric-coated tablets for stomach protection. On February 26th, the patient stopped taking stomach medicine, reduced the dosage of olopatadine hydrochloride tablets (from 1 tablet / day in the morning and evening to 1 tablet / day in the evening), and only took Chinese herbal prescription I as usual. On March 1st, the skin on the whole body was restored to a healthy state without any scars, the feeling of stomach distension disappeared, the pain had completely disappeared, and healing was restored. The patient still continued to take Chinese herbal prescription I, and took 1 tablet / day of olopatadine hydrochloride tablets, an antihistamine, for supplementation, which was used to control the occasional mild itching of the whole body and the concomitant anal itching, and at the same time enhanced the treatment results. After adding Chinese herbal prescription I (or prescription II, or its adjusted prescription) to the treatment of the patient's chronic spontaneous urticaria with Western medicine, the patient's daily symptoms of stomach distension, stomach and anal pain, anal itching, whole-body erythema, roseola on the palms of the hands, and whole-body itching were all significantly alleviated, and the quality of sleep at night improved gradually. Although the symptoms sometimes recurred during a period, overall the condition was significantly cured, and the symptom control effect was much better than that of using Western medicine alone.

[0031] A typical healing process of a skin rash is shown in patient 3 of the accompanying drawings.

[0032] Patient 4: Familial (hereditary) chronic spontaneous urticaria, female, 60 years old.

[0033] The patient stated that his mother had suffered from chronic spontaneous urticaria: arm hypersensitivity, cutaneous angioedema and severe itching. The patient had skin hypersensitivity disease since childhood, and the patient's whole body, including the back, lower back, abdomen, neck, and limbs, had generalized cutaneous angioedema, erythema, roseola, and severe itching. The size of the edema varied, the parts were connected like a surface, the color of the skin was light red, the color of the erythema and roseola was deep red, and most of the rashes protruded into the skin. Complications included chronic conjunctivitis, itching in the ear canal, anal itching, genital itching, the eyeballs and inner eyelids were always blood-red, and he had itchy eyes for many years. The patient had been taking antihistamines levocetirizine hydrochloride and chlorpheniramine maleate for a long time, but the treatment was ineffective, and after the recurrence, the symptoms did not improve at all. The patient had also tried the Chinese herbal medicine Golden Cicada Antipruritic Capsules and Chinese herbal decoction (other prescriptions), but none of these treatments effectively controlled the severe itching throughout the body.

[0034] From April 8, 2022, he took a mixed prescription of Chinese herbal medicine prescriptions I and II: 10g of Qinghai, 6g of Scutellaria, 10g of Scutellaria, 10g of Forsythia, 10g of Perilla, 6g of Coptis Rhizome, 10g of Salvia officinalis, 9g of Licorice, 9g of White Root, 15g of Purple Flower, 6g of Mint, 10g of Dandelion, 12g of Angelica, 12g of Magnolia, 5g of Bighorn, 10g of Koju, 5g of Salvia miltiorrhiza, and 9g of Ginger, for a total of 7 pairs and 18 kinds. After taking the medicine, the skin angioedema was significantly reduced and alleviated, the itching was also alleviated synchronously, the erythema and roseola were significantly reduced, and the quality of sleep improved. The patient was asked to continue taking the Chinese herbal medicine granule prescription, and then the patient was given a mixed prescription of the Chinese herbal medicine prescription I and prescription II, which was the analyzed prescription, and the number of kinds was 19 to 21. From the time of administration until the end of July 2022, the chronic urticaria symptoms and their complications, such as severe skin angioedema, severe skin itching, genital itching, red and swollen eyes, which frequently attacked the whole body, were greatly alleviated, and by August, the patient's whole body rash and itching symptoms had become sufficiently mild. From August 30 to September, due to climate change and cold weather, the patient's chronic spontaneous urticaria worsened again, but the time when the worsened skin angioedema and its itching appeared was very short, and generally it took more than 20 minutes from the attack to disappearance, and the symptoms rarely became serious, and there was no severe skin angioedema and severe itching. After 10 months, the patient's whole body did not show any angioedema again, the duration of the occasional itching did not last long, and the series of symptoms such as ear canal itching, chronic conjunctivitis, genital itching, and anal itching, which are complications of chronic urticaria, gradually became milder and gradually disappeared. The patient continued to take Chinese herbal granules Prescription I, Prescription II, and the mixed prescription of Prescription I and Prescription II, which further eradicated the pathogens of hypersensitivity and strengthened the previous treatment effect.

[0035] A typical healing process of a skin rash is shown in patient 4 of the accompanying drawings.

[0036] Patient 5: Acquired chronic spontaneous eczema, female, 35 years old

[0037] On August 27, 2021, the patient visited the Department of Traditional Chinese Medicine at Bengbu City Traditional Chinese Medicine Hospital for severe eczema on both thighs. Every year at the beginning of summer, the patient's chronic eczema on both thighs would spontaneously attack, with filled papules, reddish rash around the papules, and irregular red rash. The itching was severe, especially at night, and the quality of sleep was particularly poor. After the autumn came, the eczema disappeared naturally. This disease appeared after 9 years of pregnancy and childbirth. When the previous patient's chronic eczema had an attack, she also took Chinese herbal decoctions orally to treat it, and the itching control effect was significant, but the prescription used brought serious burden to the digestive system and caused serious diarrhea, and the effect of the prescription on controlling itching gradually decreased. The prescription was determined through analysis by the Chinese medicine department: 8g of fried bran atractylodes rhizome, 10g of Phellodendron amplexicaule, 10g of jiang zhuang bao jiang, 8g of jiang porphyra, 10g of coix seed, 15g of fried gypsum, 15g of fried malt, 8g of fried bran atractylodes rhizome, 10g of Dioscorea gracilis, 10g of scutellaria baicalensis, 8g of radix serrata, and 8g of gypsum sieboldii, a total of 7 sets of 12 kinds of Chinese herbal medicines, and the patient was to take one set every day, half in the morning and half in the evening, decoction with water. After the patient took the prescription, the eczema on both thighs was still very itchy and could not sleep at night, so he stopped taking the medicine after taking three sets of medicines.

[0038] From August 31, the patient took orally and applied an adjusted prescription (granules) from the Chinese herbal prescription I used by Patient 1, which had been removed from the formula, Red Sage, Chinese Herb, and Angelica Root, and added the ingredients contained in the Chinese herbal prescription II, Cnidium Officinalis 6g, Silver Ginseng 10g, and Dandelion 10g, and took half a dose each morning and evening with 300ml of cooled boiled water. After taking the Chinese herbal prescription I (adjusted prescription), the intense itching of the eczema on both thighs was quickly alleviated, but applying the liquid from the Chinese herbal prescription I (adjusted prescription) to the rashes on both thighs caused an increase in the itching of the rashes within a short period of time. (Analysis: The herbal liquid was applied to the rash, stimulating the pathogens in the rash and increasing the activity of pathogens that were not suppressed and killed, resulting in an increase in the itching of the rash within a short period of time. After taking the four sets of medicines, the patient's eczema symptoms on both thighs were significantly alleviated, the severe itching was relieved, and the rash on both thighs and the skin scratched during the itching were crusted. After that, when the patient took Chinese herbal prescription I, diarrhea occurred. Since the diarrhea was not serious, the patient was advised to continue taking the medicine. Taking this Chinese herbal prescription can increase the detoxification of the patient's body, and a certain amount of diarrhea is beneficial to the rapid healing of the patient's eczema, so the patient's medication status was not changed and he continued to take the medicine for more than two months. In the summer of 2022, the eczema rash on both thighs and other parts of the body was no longer present, and the severe chronic spontaneous eczema that had lasted for more than nine years was cured.

[0039] A typical healing process of a skin rash is shown in patient 5 of the accompanying drawings.

[0040] Patient 6: Familial (hereditary) chronic spontaneous eczema, male, 12 years old.

[0041] The patient's father suffered from severe hand eczema, with cracks and peeling, roseola, and severe itching, and then the hand eczema symptoms subsided and generalized itching appeared, especially on the back, inner upper thigh muscles, and scrotum area. The patient had suffered from chronic spontaneous idiopathic eczema since birth, with severe hand eczema peeling, cracks and bleeding, roseola, severe itching in summer, and urticarial papules appeared on the forehead, which persisted for the entire summer and did not go away for half a year. From October 5, 2022, a mixed and adjusted prescription of prescription I and prescription II (herbal medicine granule prescription): Coptis Rhizome 6.3g, Scutellaria Root 10g, Forsythia Root 10g, Perilla Leaf 10g, Heavenly Pollen 10g, 10g, Licorice Root 9g, Honey 100g, Gold Mint 10g, Mint 12g, Pearl Pepper 10g, Dandelion 10g, Fried Fu Atractylodes Root 3g, Salvia Anemone 10g, Purple Flower Diplodiae 10g, Cnidium Root 6g, Scutellaria Root 10g, Chrysanthemum Root 10g, and Liquorice Root 10g, a total of 7 pairs and 19 kinds were tried. One pair per day, half of which was taken orally in the morning and evening with 100ml of cooled boiled water. When taking the medicine orally, a small amount of herbal medicine liquid was applied to the hand eczema. On October 9th, after taking and applying three sets of Chinese herbal granules, the urticarial papules on the forehead, which had lasted for half a year, began to disappear noticeably, the severe hand eczema stopped peeling, the roseola gradually disappeared, and the hand eczema and urticarial papules on the forehead improved rapidly at a speed that could be judged by the human eye. On October 14th, after taking and applying seven sets of Chinese herbal granules, the peeling and roseola symptoms of the hand eczema all disappeared, and the hand skin was completely restored to a healthy state. In order to strengthen the treatment effect and thoroughly eradicate the pathogen, the patient continued to take the Chinese herbal granules.

[0042] A typical healing process of a skin rash is shown in patient 6 of the accompanying drawings.

[0043] Patient 7: Acquired chronic spontaneous urticaria (severe dermatographia), hand eczema, male, 40 years old.

[0044] On May 16, 2020, the patient reported that he had been suffering from urticaria for more than a year without any trigger, and that during attacks, the inner thigh muscles were itchy severely. When taking a bath, he was unable to rub the skin on the inner thigh with his hands, otherwise, erythema immediately appeared at the friction site and the itching was severe. After bathing, the itching worsened, accompanied by erythema, and after scratching, the epidermis had ulcers and blood-red color appeared. The patient was given prescription granules that were cross-adjusted with the ingredients of Chinese herbal prescription I and Chinese herbal prescription II. There were a total of five sets of Chinese herbal prescription I (ingredients adjusted), and one set was taken daily, fully dissolved in about 300 ml of cooled boiled water, and half was taken in the morning and evening, or three times in the morning, afternoon, and evening. At the same time, the prescription aqueous solution was applied to the areas with severe skin itching. After taking the first set, the itching in the inner thigh muscles seemed to worsen, but the nerves of the whole body were relaxed and calmed, the mind was tired, and the quality of sleep that night was very high. After the second set, the itching symptoms in the inner thigh muscles improved significantly, and the habitual itching disappeared after bathing. After the fifth set, the symptoms disappeared, and the itching in the inner thigh muscles disappeared again after bathing. Next, the patient took Chinese herbal prescription II (component adjustment), for a total of three sets, one set per day, dissolved thoroughly in about 300 ml of cooled boiled water, and taken half in the morning and evening, or three times in the morning, afternoon, and evening. After starting to take Chinese herbal prescription I, and then after taking Chinese herbal prescription II, the patient became sleepy all day, indicating that the nerve sedative effect of the drug was very strong and the nervous system of the body was completely relaxed. When taking a bath, the itching did not occur again even when the skin was rubbed with hands.

[0045] On September 11, 2020, the patient was interviewed again and found that because he had to wear plastic protective gloves at work, the ten fingers of both hands were filled with rice-sized acne for a long time, and the itching was severe. When the acne was pierced, liquid came out, the ten fingers were swollen and painful, and some parts were cracked, and the skin was dry and peeled off. According to the symptoms, it was determined that it was hand eczema. The pathogenesis of eczema and urticaria is similar, and the root cause of both is infection by microbial pathogens in the body. Therefore, the patient took Chinese herbal medicine prescription I (granules), a total of 10 sets, one set per day, fully dissolved in about 300 ml of cooled boiled water, half in the morning and evening, and if the skin itching is severe, it can be applied at the same time. After taking three sets, the swelling of the ten fingers was relieved, the skin cracks were reduced, and the itching was relieved. After taking the 4th and 5th sets, mild diarrhea appeared, swelling and pain in the ten fingers of both hands disappeared, itching disappeared, skin cracks gradually healed, dry skin was relieved, but skin still peeled off. From the 7th to 8th sets, mild stomach discomfort appeared, gastric acid reflux and bitter taste, bitter taste in the mouth, dry skin on hands, and other symptoms disappeared except for skin peeling.

[0046] A typical healing process of a skin rash is shown in patient 7 of the accompanying drawings.

[0047] Patient 8: Acute urticaria, male, 37 years old.

[0048] In August 2020, the patient sprayed pesticides on the rice paddy the day before and returned home. After that, pimples of various sizes started to appear on the right lower back, and the pimples were connected to cover the entire area. There was bright red hypersensitive skin around the pimples, and the itching was severe and very unbearable. (The patient stated that he had a hypersensitive constitution and that he often had an itchy back when sleeping at night.)

[0049] A total of 12 kinds of ingredients from Chinese herbal formula I and Chinese herbal formula II: 10g of celestial pollen, 12g of angelica, 10g of dandelion, 10g of Scutellaria root, 10g of Pearl Root, 10g of Scutellaria root, 10g of Scutellaria root, 6g of Cinnamon bark, 10g of Forsythia, 10g of Salvia officinalis, 9g of Licorice root, 10g of Fried Bianco seed, and 10g of Atractylodes macrocarpa were selected, and four sets of prescriptions (Chinese herbal granules) were selected, which were taken orally and applied to the rash at the same time. Two sets of the medicine were taken twice a day, one set every day, and dissolved thoroughly in 200ml of cooled boiled water, and half of the medicine was taken orally in the morning and evening, and applied to the rash at least three to four times a day. After taking one set of the medicine orally, a small amount was left and applied to the rash at the same time, and the intense itching symptoms disappeared, and the bright red skin around the rash and edema that had become sensitive and acne-prone changed to mild itching, and the prescription was then taken orally and applied, and the symptoms gradually improved. After taking the four sets of medicine, the edema of the skin disappeared, the itching disappeared completely, and the sensitive bright red skin was transformed into red mung bean-sized papules. The patient did not take the medicine because he disliked that it was too bitter, and the sensitivity symptoms gradually disappeared naturally thereafter.

[0050] Patient 9: Acquired chronic spontaneous urticaria, male, 19 years old.

[0051] The patient had been suffering from severe itching on his back, inner upper thighs, scrotum and anus for many years, which would attack for no apparent reason and spread to other areas with no fixed location. The itching would become particularly severe before or during weather changes, and the itching was severe at night. The patient had been undergoing treatment for many years. None of his parents or other direct relatives had any hypersensitive diseases.

[0052] From April 12, 2020, I started taking Chinese herbal prescription 3 (Chinese herbal medicine granules) (containing some of the ingredients of Chinese herbal medicine prescription I): Gang Hou Magnolia 12g, Angelica Root 12g, White Atractylodes Root 10g, Scutellaria Root 10g, Pearl Germ Root 10g, Scutellaria ...6g, Coptis Rhizome 6g, Cinnamon Bark 6g, Forsythia Root 10g, Anemone Rhizome 10g, Licorice Root 9g, and Roasted Bianthus Fruit 10g, a total of 15 sets of 12 kinds of medicines, and one set was dissolved thoroughly in 200ml of cooled boiled water every day, and half was taken in the morning and evening.

[0053] After that, he took Chinese herbal prescription 4 (Chinese herbal medicine granules) (taking some of the ingredients of Chinese herbal medicine prescriptions I and II): Dandelion 10g, Atractylodes Root 10g, Scutellaria Root 10g, Pearl Radix Root 10g, Scutellaria Root 10g, Scutellaria Root 10g, Cinnamon Bark 6g, Forsythia Root 10g, Anemone Rhizome 10g, Licorice Root 9g, Heavenly Pollen 10g, Rhubarb 6g, and Angelica Root 6g, a total of 20 sets of 12 kinds of medicines, and the method of taking it was the same as prescription 3. After taking it, he had diarrhea (the prescription contains 6g of Rhubarb, which is used for detoxification).

[0054] Previously, the patient had taken Skin Disease Blood Decoy Pill - Tongrentang orally to treat chronic urticaria symptoms. Comparing Prescription 3, Prescription 4 and Skin Disease Blood Decoy Pill - Tongrentang, the medicinal effects of the three drugs were similar, and the itching symptoms were alleviated after taking the medicine.

[0055] In February 2021, the patient took Chinese herbal prescription I and Chinese herbal prescription II granules.

[0056] The patient stated that the efficacy of Chinese herbal prescription I and Chinese herbal prescription II was better than those of prescription 3, prescription 4, and skin disease blood poison pills, and the anti-itching effect was better, but it was not as good as ebastine in suppressing itching. After taking ebastine, the hypersensitivity symptoms were quickly controlled and the itching completely disappeared, but the urticaria soon recurred spontaneously, and the symptoms were the same as before and did not improve at all. The patient continued to take ebastine for more than 6 months of treatment, and during the treatment period, when hypersensitivity and itching symptoms appeared, he took ebastine, and when the symptoms disappeared, he stopped taking the medicine. After a course of treatment for more than 6 months, the frequency of chronic spontaneous urticaria attacks did not decrease, and the wheals and itching did not improve.

[0057] Patient 10: Chronic spontaneous urticaria complicated by digestive system disease, male, 31 years old.

[0058] On January 14, 2021, the patient reported that he was an emergency physician and had suffered from urticaria for many years. The attacks occurred spontaneously without any obvious trigger, but when the urticaria recurred, wheals and bumps appeared on his arms and shoulders, and bright red wheals appeared on his back and inner upper thighs. The hypersensitive wheals and rashes on other parts of the body were widespread and the attacks had no fixed location, and the itching was severe and unbearable, and the attacks had been repeated for many years. For many years, he had diarrhea symptoms, accompanied by a slight pain in the gastrointestinal tract, and the discomfort was very pronounced, especially at dawn every day, which was particularly painful (this is also a common coexisting gastrointestinal disease in patients with chronic urticaria). Before treating the disease with a Chinese herbal prescription, he had used multiple types of topical ointments, but none of them were able to stop the itch. The patient was recommended to try three Chinese herbal prescriptions to control the symptoms of chronic urticaria.

[0059] The patient was given one sachet of the Chinese herbal medicine Urticaria pills, one in the morning and one in the evening. After taking the medicine, the patient experienced acid reflux, abdominal pain, and diarrhea. He also experienced severe itching of the skin at night that could not be controlled, so he stopped taking the medicine after taking it for two days.

[0060] Chinese herbal formula I (component-adjusted granules): Removed Atractylodes arbutus, Menmakanshu, Scutellaria baicalensis, Forsythia spp., added cinnamon, 5 sets in total, 1 set per day, fully dissolved in about 300ml of cooled boiled water, and half taken in the morning and evening.After taking half of this formula, it was applied to the area with severe skin itching at the same time, quickly relaxing the nervous system of the whole body, making the skin comfortable and relaxed, relaxing the nerve endings of the skin and sharpening the senses, completely controlling the itching of the whole body, and at night when sleeping, the itching of the severe itching area disappeared, making the patient feel relaxed, and the quality of sleep was also greatly improved.Further taking this formula, diarrhea was alleviated, and the discomfort of the gastrointestinal tract at dawn disappeared.

[0061] Chinese herbal prescription II (prescription granules cross-reacted with the components of prescription I): Removed Clove, Cornus officinalis, Medicago sativa, Ginger, Rheum officinale, and Thousand Li Guang, and added Scutellaria baicalensis, Forsythia frutescens, and Roasted Atractylodes macrocarpa, a total of 5 sets, 1 set per day, fully dissolved in about 300ml of cooled boiled water, and half taken in the morning and evening. This prescription cannot completely stop itching, and the source of infection in the body is guided to the skin. When taking the first 3 sets, the skin itching of the arms, shoulders, and inner upper thighs increased, and at the same time, relatively severe angioedema appeared, and several parts of the arms and shoulders showed large edema connected in an integrated manner. At the same time, the medicinal liquid of Chinese herbal prescription II was applied, and the itching was relieved. After taking the medicine, the symptoms of skin hypersensitivity increased, but the patient consciously played an active therapeutic role, and the nervous system of the whole body was relaxed, and the nervous excitement disappeared.

[0062] Patient 11: Chronic spontaneous urticaria, female, 60 years old.

[0063] The patient suffered from chronic spontaneous urticaria for many years, with scattered erythema all over the body, and angioedema of various densities and sizes in the upper limbs, head, neck, and knee joints, showing skin color, severe itching, especially at night, and poor quality of sleep. After more than two years of treatment, the patient was treated with oral administration of antihistamine chlorpheniramine maleate tablets and hormone dexamethasone tablets, and after oral administration of hormone, the itching effect was good, but after stopping the medication, the itching recurred and the face, eyes, hands and feet sometimes swelled, and the long-term treatment did not cure it. Tried to treat with prescription decoction of Chinese medicine, but the itching effect was poor.

[0064] In March 2022, Patient 1 was interviewed at the recommendation of a friend. Because the patient was deaf and mute, his friend reported that the patient's itching symptoms were not very serious, and the patient's skin rash symptoms at the time were not severe either. Therefore, he prescribed Chinese herbal medicine (Chinese herbal medicine granules): 9g of licorice, 12g of peppermint, 10g of fried wheat atractylodes, 10g of goju, 10g of dandelion, 10g of eel syrup, 10g of silver ginseng, 15g of ginseng, and 15g of cinnamon. It was recommended to use 12g of twigs, 10g of roasted burdock, 10g of Peony root, 10g of white fresh bark, 10g of mulberry leaves, 10g of chrysanthemum, 10g of magnolia, 10g of Scutellaria root, 6g of ephedra, 10g of thorns, and 6g of sophora root, a total of 5 sets of 19 kinds of medicines, one set per day with 300ml of cooled boiled water, taken orally and applied to the area with severe skin itching, half in the morning and evening, or one set in the morning, afternoon, and evening, divided into three times. After the patient took the prescription, the skin rash suddenly worsened, with erythema, roseola, and angioedema, and the itching increased and spread to the whole body. The prescribed herbal liquid was applied to slightly relieve the itching, but the itching was still severe, and after taking the fourth and fifth sets, the patient felt chills. (Analysis: The patient had been suffering from chronic urticaria for many years and the condition was very serious. Although the prescription could not completely control the patient's symptoms, it had a certain therapeutic effect, but instead guided the pathogens in the patient's body to the skin on the body surface, resulting in an increase in the rash symptoms and increased itching. The rash was accompanied by cutaneous angioedema, and the patient experienced chills.) After the prescription was used up, it was discontinued.

[0065] After that, the patient uses the granules of Chinese herbal medicine prescription I, takes it orally and applies it to the skin of the severe itching area, and when the whole body itching attacks, takes antihistamine and hormone dexamethasone tablets at the same time.After taking Chinese herbal medicine prescription I, the skin rash symptoms are still severe, but the severe itching is relieved, and the night sleep is improved, and after taking the medicine, the body feels warm.After taking 7 sets of this prescription, the whole body erythema, roseola and the coexisting skin angioedema all disappear, the whole body itching is no longer significant, and the quality of night sleep is greatly improved. After that, the patient continued to take Chinese herbal prescription I, Chinese herbal prescription II and the mixed prescription of the two prescriptions, and the patient's skin rash attacks were repeated during the period, and the itching persisted. During the skin rash attacks, a large area of ​​erythema spread, and sometimes a small area of ​​round or oval rose rash appeared on the skin, and sometimes papules were scattered, and the symptoms became more severe and more severe. When the severe and severe skin rash and erythema appeared, the patient took a hormone, dexamethasone tablet, for anti-inflammatory effect, and the skin symptoms also disappeared quickly, but the next day the skin symptoms recurred. Previously, when the patient did not take Chinese herbal prescription I and Chinese herbal prescription II, but only took hormones and antihistamines, the skin rash and erythema of the patient's skin were controlled, but the patient had systemic edema symptoms such as red and swollen eyes, swollen face, and swollen limbs. After taking Chinese herbal prescription I and Chinese herbal prescription II, and using dexamethasone tablets and antihistamines as auxiliary drugs to control the severe and intense skin symptoms and itching, the patient's symptoms of generalized edema and eye swelling almost never reappeared, and the severity of the generalized itching was greatly alleviated, and the quality of sleep at night was also greatly improved. The patient's skin symptoms such as rash and erythema tended to gradually increase after treatment with Chinese herbal prescription I and II (this situation is an expression of the discharge of damp-heat toxins from the body, which is consistent with the discipline characteristics of treating chronic urticaria with Chinese herbal medicine). By July and August, the patient's rash and erythema reached their most severe state, and the skin symptoms were severe to severe throughout, but the patient's severe generalized itching gradually decreased throughout. From September 20th, the patient's skin rash and erythema were significantly alleviated, and by the end of September, the patient's skin symptoms recurred and were of moderate or below severity. After October 10th, the patient's skin symptoms, such as rash and erythema, had already become mild, and there was also a qualitative change in the degree of itching.The patient continued to take Chinese herbal prescription I, Chinese herbal prescription II and the combined prescription of the two prescriptions to completely cure her chronic spontaneous urticaria.

[0066] A typical healing process of a skin rash is shown in patient 11 of the accompanying drawings.

[0067] Patient 12: Allergic rhinitis complicated by allergic conjunctivitis, male, 12 years old.

[0068] The patient would get up early every day, sneeze, and often have itchy eyes, which manifested as chronic conjunctivitis. It was determined that the rhinitis and conjunctivitis were of a sensitive nature. On August 8, 2022, the patient began to take 18 kinds of Chinese herbal medicine granules, which were prepared by mixing Chinese herbal medicine prescription I and Chinese herbal medicine prescription II. After taking 8 sets of the prescription, the patient felt that the number of morning sneezes had decreased slightly, nasal congestion phenomenon began to appear, chronic conjunctivitis symptoms in the eyes still existed, and the eyes became uncomfortable. After taking the medicine, the frequency of urination increased, there was no diarrhea, and there was no stomach discomfort. After taking 15 sets, the number of morning sneezes seemed to have decreased significantly, and after nasal congestion, there was a slight runny nose by chance. After taking 35 sets of the medicine, according to intuitive sense, the symptoms of nasal congestion were no longer serious when sleeping at night, and the situation changed significantly. After that, 10 sets of 19 kinds of Chinese herbal medicine granule prescriptions, which were prepared by mixing Chinese herbal medicine prescription I and Chinese herbal medicine prescription II, were used. After taking 45 sets of medicine, 20 kinds of Chinese herbal medicine granule prescriptions, which were prepared by mixing Chinese herbal medicine prescription I and Chinese herbal medicine prescription II, were used. After taking 50 sets of Chinese herbal medicine granule prescriptions, the number of days without sneezing in the morning increased from 2 to 3 days to 4 to 5 days in a row, allergic rhinitis was significantly improved, nasal congestion and runny nose symptoms were significantly reduced, and the itching sensation of chronic conjunctivitis of the eyes became milder. In order to strengthen the previous treatment effect and cure the rhinitis and conjunctivitis caused by hypersensitive constitution, the patient continued to take the 20 kinds of Chinese herbal medicine granule prescription, which was prepared by mixing Chinese herbal medicine prescription I and Chinese herbal medicine prescription II.

Claims

1. The ingredients of Chinese herbal formula I are scientific extracts of 20 kinds of Chinese herbal medicines, namely, Scutellaria Root, Coptis Rhizome, Forsythia Root, Perilla Root, Magnolia Root, White Atractylodes Root, Angelica Root, Radix Radix, Radix Peppermint, Scutellaria Baicalensis, Scutellaria Baicalensis, White Atractylodes Root, Atractylodes Rhizome, Scutellaria Baicalensis, Licorice Root, Mint Root, Coptis Rhizome, Salvia Root, Purple Sage, and Large Green Leaf. The contents of the 20 kinds of Chinese herbal medicines are as follows: Scutellaria Root 9g-10g, Coptis Rhizome 6-8g, Forsythia Root 10-12g, Perilla Root 10g, Ginger Magnolia Root 10-12g, Roasted Atractylodes Root 10g, Angelica Root 10-12g, Radix Peppermint Root 10-12g, Roasted Scutellaria Baicalensis Root 10-15g, Scutellaria Baicalensis Root 9-12g, and Radix Peppermint Root 10-15g. The scientific extracts of these 20 kinds of Chinese herbal ingredients are used to make Chinese herbal prescription I, which is made into oral medication such as oral pills, powder or capsules, and at the same time, the extracts of these 20 kinds of ingredients are used to make topical medication such as external medicine, ointment or medicinal patch, which are used in conjunction with the oral medication to be applied to areas of severe itching on the skin, and are used for external use, etc.

2. The ingredients of Chinese herbal formula II are scientific extracts of 21 kinds of Chinese herbal medicines, namely, licorice, mint, Cnidium, Rhizome, Dandelion, Rhubarb, Qianliguang, ginger, Chinese ginger, Chinese ferns, Chinese ferns, Euonymus sieboldii, Peony root, Magnolia, Chinese husk, Cuckoo Root, Chinese Coptis, White Fresh Skin, Jingjiang, and chrysanthemum. The contents of the 21 kinds of Chinese herbal medicines are 9-10g of licorice, 6-12g of mint, 6-10g of Cnidium, Rhizome, 5-6g of Chinese ferns, 15-20g of Qianliguang, 15-20g of Euonymus sieboldii, 9-10g of Chinese ferns, 10-15g of Chinese ferns, 10-15g of Chinese ferns, 9-15g of Chinese ferns, 10 ... The scientific extracts of these 21 ingredients make up Chinese herbal formula II, which is made into oral medications such as oral pills, powders or capsules, and at the same time, the extracts of these 21 ingredients are made into topical medications such as external medicinal solutions, ointments or medicinal patches, which are used in conjunction with the oral medications to be applied to areas of severe itching on the skin, and are used for external use, etc.

3. Some of the ingredients in Chinese herbal prescription I and Chinese herbal prescription II, a total of 39 ingredients, are randomly selected to form 16 to 21 Chinese herbal prescriptions, and the content of each ingredient is determined by the corresponding ingredient content in claim 1 and claim 2. The effective ingredients of each ingredient are scientifically extracted, and the effective ingredients are used to form the Chinese herbal prescription and further make oral or external medications.

4. According to the above claims 1, 2 and 3, the above Chinese herbal prescription or some of its active ingredients are extracted to prepare a prescription, and oral pills, powders, granules, tablets, capsules, etc. are made, or the active ingredients of the prescription are extracted to prepare an injection, or the above Chinese herbal prescription or some of its active ingredients are extracted to prepare an external medicine such as an ointment, medicinal liquid, medicinal patch, or a medicinal bath product, all of which are within the scope of protection of the patent. The invention is for treating various acute and chronic urticaria, acute and chronic eczema, hypersensitive / allergic constitution, and allergy-fighting. Allergic conjunctivitis, chronic pharyngitis, allergic rhinitis / sinusitis, allergic bronchitis / asthma, oral suppurative infection, sticky / thick tongue coating, severe bad breath, chronic (ulcerative) intestinal gastritis, colitis, proctitis, concurrent joint and muscle pain, fatigue, concurrent ear canal itching, genital itching, scrotal itching, anal pain and itching, bloodshot eyes and itching, etc., as well as complications such as poor quality sleep, biological clock / endocrine disorder, cranial nerve weakness, mental lethargy / excitement and alternating appearance, influenza virus, scabies mites, Helicobacter pylori, Helicobacter pylori, Mycoplasma pneumoniae, diarrheal bacillus, various psoriasis fungi, etc. are also treated.

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