Methods and compositions for targeted delivery via polymersomes

The polymersome design with a glycan head and zwitterionic groups addresses the issue of selective delivery and encapsulation, providing stable and efficient delivery to target cells.

JP2025536873AActive Publication Date: 2025-11-12ROCK BIOMEDICAL INC
View PDF 3 Cites 0 Cited by

Patent Information

Application Number
JP2025516139
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-04-05
Filing Date
2024-04-08
Publication Date
2025-11-12
Estimated Expiration
2044-04-08

AI Technical Summary

Technical Problem

Existing polymersomes lack selective delivery capabilities and efficient encapsulation of drug molecules, particularly nucleic acids, and are unstable in serum.

Method used

A polymersome design comprising a copolymer with an initiator block and a propagator block connected by a disulfide bond, featuring a glycan head for targeting and zwitterionic groups for stability, enabling selective delivery and efficient payload encapsulation.

Benefits of technology

The polymersome achieves targeted delivery to specific cells, such as dendritic cells, with enhanced stability and efficient payload release, improving therapeutic efficacy.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 2025536873000001_ABST
    Figure 2025536873000001_ABST
Patent Text Reader

Abstract

The present disclosure relates to copolymers and polymersomes for targeted delivery of biomolecules to living organisms. Exemplary copolymers include an initiator block, a propagator block, and a linker connecting the initiator block and the propagator block. The initiator block includes a glycan head configured to provide targeted delivery, and the propagator block includes a functional moiety configured to provide desired properties to the polymersome.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Self-assembling amphiphilic polymers as antiviral drugs

    JP2010516673A

  • Self-assembled particles from zwitterionic polymers and related methods

    JP2013510229A

  • Therapeutic nanoparticles and methods of use thereof

    WO2020058239A1