Liquid oral compositions

Abstract

To provide a liquid composition for oral cavity, which has a good use feeling, can exhibit a moderate retention feeling, and can suppress generation of a precipitate at a high temperature.SOLUTION: A liquid composition for oral cavity, comprising (A) glycyrrhizic acid or a salt thereof and (B) vitamin E, wherein the content of the component (A) is 0.05 to 0.20 mass%, the content of the component (B) is 0.01 to 1 mass%, and the content of water is 45 to 90 mass%.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a liquid oral composition. [Background technology]

[0002] Vitamin E, such as tocopherol, has an anti-inflammatory effect and also promotes peripheral circulation in gingival tissues (promotes blood circulation), and is therefore a component commonly used in liquid oral compositions as a seed for preventing periodontal disease (Patent Documents 1 to 3). Vitamin E also enhances the retention of the formulation in the gums. However, vitamin E has a problem in that when it is used in a liquid oral composition, it may produce precipitates when stored at high temperatures. Furthermore, liquid oral compositions containing vitamin E have room for improvement in terms of the feel when held in the mouth. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2008-007413 [Patent Document 2] Japanese Patent Application Laid-Open No. 2015-110664 [Patent Document 3] Japanese Patent Application Laid-Open No. 2013-129620 Summary of the Invention [Problem to be solved by the invention]

[0004] The present invention has been made in consideration of the above circumstances, and aims to provide a liquid oral composition that contains vitamin E as an active ingredient, has a good feel when used, provides a moderate retention feeling, and can suppress the formation of precipitates at high temperatures. [Means for solving the problem]

[0005] As a result of extensive research to achieve the above-mentioned objective, the inventor discovered that by incorporating a specific amount of glycyrrhizinic acid or a salt thereof in the presence of vitamin E, it is possible to provide a liquid oral composition that has a good feel when used, exhibits a moderate retention sensation, and produces no precipitates after storage at high temperatures, and thus completed the present invention.

[0006] That is, the present invention includes the following inventions. [1] (A) glycyrrhizinic acid or a salt thereof and (B) vitamin E, 0.05 to 0.20 mass% of component (A), 0.01 to 1% by mass of component (B), and Moisture content: 45 to 90% by mass A liquid oral composition containing [2] A liquid oral composition described in [1] further containing (C) at least one surfactant selected from a nonionic surfactant and an anionic surfactant. [3] A liquid oral composition according to [2], containing 0.2 to 2 mass% of component (C). [4] A liquid oral composition described in any one of [1] to [3], wherein the mass ratio of (A) / (B) is 1 or more. [Effects of the Invention]

[0007] According to the present invention, there is provided a liquid oral composition that contains vitamin E, has a good feel when used, provides a moderate retention feeling, and can suppress the formation of precipitates at high temperatures. BEST MODE FOR CARRYING OUT THE INVENTION

[0008] The present invention will be described in further detail below. The liquid oral composition of the present invention (hereinafter also referred to as the composition of the present invention) contains (A) glycyrrhizinic acid or a salt thereof and (B) vitamin E. The liquid oral composition of the present invention may further contain (C) at least one surfactant selected from a nonionic surfactant and an anionic surfactant. In addition to the above components, other known additives may be optionally incorporated as long as they do not impair the effects of the present invention. For example, humectants, sweeteners, pH adjusters, preservatives, suspending agents, flavorings, active ingredients, solvents, etc. may be incorporated singly or in combination of two or more, and the composition may be prepared by mixing these components with water. Liquid oral compositions generally do not incorporate non-solubilizable solid components such as abrasives, and preferably do not contain abrasives.

[0009] [Component (A): Glycyrrhizic acid or its salt] Component (A) is glycyrrhizinic acid or a salt thereof, and examples of the salt include dipotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, and monoammonium glycyrrhizinate. Glycyrrhizinic acid or a salt thereof has an anti-inflammatory effect, and dipotassium glycyrrhizinate has a selective antibacterial effect against bacteria that cause periodontal disease. In terms of further suppressing the formation of precipitates at high temperatures, glycyrrhizinic acid, dipotassium glycyrrhizinate, and monoammonium glycyrrhizinate are preferred, with dipotassium glycyrrhizinate being more preferred. Component (A) may be one selected from glycyrrhizinic acid and its salts, or a combination of two or more.

[0010] The lower limit of the amount of component (A) to be blended is 0.05% or more (% by mass, the same applies hereinafter) of the entire composition. When the amount of component (A) to be blended is 0.05% or more, the feeling of being heavy in the mouth can be suppressed, the feel in use can be improved, and the occurrence of precipitates at high temperatures can be suppressed. The lower limit of the amount of component (A) to be blended is preferably 0.06% or more of the entire composition, and more preferably 0.07% or more. When the amount to be blended is equal to or greater than the above lower limit, the feeling of being heavy in the mouth can be further suppressed, the feel in use can be further improved, and the occurrence of precipitates at high temperatures can be further suppressed. The upper limit of the amount of component (A) is 0.20% or less of the total composition. When the amount of component (A) is 0.20% or less, the staying power of the formulation can be enhanced. The upper limit of the amount of component (A) is preferably 0.19% or less of the total composition, and more preferably 0.17% or less. When the amount is less than the above upper limit, the staying power of the formulation can be further enhanced. Therefore, the amount of component (A) is 0.05 to 0.20% of the total composition, preferably 0.06 to 0.19%, and more preferably 0.07 to 0.17%.

[0011] [Component (B): Vitamin E] (B) Examples of vitamin E (hereinafter also referred to as VE) include d-α-tocopherol, dl-α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, and derivatives thereof (e.g., esters or salts with organic acids such as acetic acid, nicotinic acid, succinic acid, and linolenic acid). Examples of the derivatives include d-α-tocopherol acetate, dl-α-tocopherol acetate (tocopherol acetate), d-α-tocopherol nicotinate, dl-α-tocopherol nicotinate, d-α-tocopherol succinate, dl-α-tocopherol succinate, d-α-tocopherol linolenate, dl-α-tocopherol linolenate, and calcium tocopherol succinate. As VEs, dl-α-tocopherol, dl-α-tocopherol acetate (tocopherol acetate), and dl-α-tocopherol nicotinate are particularly preferred because they are highly physiologically active and colorless to pale yellow, so they have little effect on the color tone or appearance of the formulation. VEs can be formulated either alone or in combination of two or more.

[0012] The lower limit of the amount of component (B) in the total composition is 0.01% or more. When the amount of component (B) in the total composition is 0.01% or more, a decrease in the staying feeling of the formulation can be suppressed. The lower limit of the amount of component (B) in the total composition is preferably 0.025% or more, more preferably 0.04% or more. When the amount in the total composition is equal to or greater than the above lower limit, a decrease in the staying feeling of the formulation can be further suppressed. The upper limit of the amount of component (B) in the total composition is 1% or less. When the amount of component (B) in the total composition is 1% or less, stability can be improved, such as suppressing the formation of precipitates at high temperatures. The upper limit of the amount of component (B) in the total composition is preferably 0.75% or less, more preferably 0.6% or less. When the amount in the total composition is equal to or less than the above upper limit, stability can be further improved, such as suppressing the formation of precipitates at high temperatures. Therefore, the amount of component (B) blended is 0.01 to 1% of the total composition, preferably 0.025 to 0.75%, and more preferably 0.04 to 0.6%.

[0013] [(A) / (B)] In the present invention, the mass ratio (A) / (B), which represents the ratio of the blending amounts of component (A) and component (B), is preferably 0.13 or more, more preferably 0.5 or more, and even more preferably 1 or more. When the mass ratio (A) / (B) is at least the above-mentioned lower limit, a sticky feeling in the mouth is unlikely to occur, and deterioration of the feel during use can be further suppressed. The upper limit of the mass ratio is preferably 10 or less, more preferably 9 or less, even more preferably 8 or less, and even more preferably 5 or less. When the mass ratio (A) / (B) is at most the above-mentioned upper limit, deterioration of the retention feel of the preparation can be further suppressed. Therefore, the mass ratio of (A) / (B) is preferably 0.13 to 10, more preferably 0.13 to 9, even more preferably 0.5 to 8, and even more preferably 1 to 5.

[0014] Furthermore, the liquid oral composition of the present invention may contain (C) at least one surfactant selected from a nonionic surfactant and an anionic surfactant. Examples of nonionic surfactants include sugar alcohol fatty acid esters such as sucrose fatty acid esters, maltose fatty acid esters, maltitol fatty acid esters, and lactol fatty acid esters, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, alkylolamides, polyoxyethylene sorbitan fatty acid esters, polyglycerin fatty acid esters, hexaglyceryl monocetylate, fatty acid diethanolamides, sorbitan fatty acid esters, polyoxyethylene higher alcohol ethers, polyoxyethylene alkyl ethers, and polyoxyethylene polyoxypropylene glycol. When an anionic surfactant is contained, it may be used alone or in combination of two or more.

[0015] Suitable nonionic surfactants include one or more selected from polyoxyethylene hydrogenated castor oils having an average number of added moles of ethylene oxide of 60 to 100, polyoxyethylene alkyl ethers having an alkyl group with 16 (cetyl) to 18 (stearyl) carbon atoms and an average number of added moles of ethylene oxide of 20 to 40, and decaglycerin monofatty acid esters having a fatty acid with 12 (lauric acid) to 18 (stearic acid) carbon atoms, particularly 12 to 14 (myristic acid) carbon atoms. Among these, polyoxyethylene hydrogenated castor oils are preferred in terms of further suppressing the formation of precipitates at high temperatures, and those having an average number of added moles of ethylene oxide of 60 to 100 are particularly preferred. When a nonionic surfactant is included, it may be used alone or in combination of two or more. As the polyoxyethylene hydrogenated castor oil, commercially available products such as NIKKOL HCO series manufactured by Nikko Chemicals Co., Ltd., EMALEX HC series manufactured by Nippon Emulsion Co., Ltd., and UNIOX HC series manufactured by NOF Corporation can be used. As the polyoxyethylene alkyl ether, commercially available products such as EMALEX 100 series and EMALEX 600 series manufactured by Nippon Emulsion Co., Ltd. can be used. As the decaglycerin mono-fatty acid ester, commercially available products such as NIKKOL Decaglyn series manufactured by Nikko Chemicals Co., Ltd. and Ryoto (registered trademark) Polyglycerol D series manufactured by Mitsubishi Chemical Foods Corporation can be used.

[0016] The amount of nonionic surfactant blended is preferably 0.1% or more, more preferably 0.15% or more, and even more preferably 0.2% or more. The upper limit is preferably 5.0% or less, more preferably 4.0% or less, and even more preferably 3.0% or less. When the blended amount is within the above numerical range, the generation of precipitates at high temperatures can be further suppressed. Therefore, when a nonionic surfactant is blended, the blended amount is preferably 0.1 to 5.0% of the total composition, more preferably 0.15 to 4.0%, and even more preferably 0.2 to 3.0%. For example, when using polyoxyethylene hydrogenated castor oil with an average number of ethylene oxide added of 60, it is preferable to blend it at 0.1 to 1.5%. When using polyoxyethylene hydrogenated castor oil with an average number of ethylene oxide added of 100, it is preferable to blend it at 0.3 to 4.0%. When using polyoxyethylene alkyl ether with an alkyl group carbon chain length of 16 to 18 and an average number of ethylene oxide added of 20 to 50, it is preferable to blend it at 0.2 to 2.0%. When using polyoxyethylene sorbitan fatty acid ester, it is preferable to blend it at 0.2 to 2.0%.

[0017] Examples of anionic surfactants include N-acylamino acid salts, N-acyltaurine salts, α-olefin sulfonates, N-acylsulfonates, alkyl sulfates, and sulfates of glycerin fatty acid esters. Among these, N-acylamino acid salts, N-acyltaurine salts, α-olefin sulfonates, and alkyl sulfates are preferred in terms of versatility, and sodium lauroyl sarcosinate, sodium lauroyl methyl taurate, sodium α-olefin sulfonate having an alkyl chain length of 10 to 16 carbon atoms, and sodium lauryl sulfate are more preferred in terms of foaming ability and hard water resistance. When an anionic surfactant is included, it may be used alone or in combination of two or more.

[0018] The amount of anionic surfactant may be 0%, but if anionic surfactant is used, the lower limit is preferably 0.001% or more, more preferably 0.01% or more, and even more preferably 0.05% or more. The upper limit is preferably 10% or less, more preferably 5% or less, and even more preferably 2% or less. Within the above numerical range, the occurrence of precipitates at high temperatures can be further suppressed. Therefore, if an anionic surfactant is used, the amount is preferably 0.001 to 10%, more preferably 0.01 to 5%, and even more preferably 0.05 to 2%.

[0019] When component (C) is contained, the lower limit of the amount of component (C) blended is preferably 0.2% or more, more preferably 0.25% or more, and even more preferably 0.3% or more, of the total composition. The upper limit of the amount of component (C) blended is preferably 2% or less, more preferably 1% or less, and even more preferably 0.6% or less, of the total composition. Within the above numerical ranges, the formation of precipitates at high temperatures can be further suppressed. Therefore, when component (C) is contained, the amount of component (C) blended is preferably 0.2 to 2%, more preferably 0.25 to 1%, and even more preferably 0.3 to 0.6%, of the total composition.

[0020] The lower limit of the ratio of the anionic surfactant to the nonionic surfactant in component (C) (anionic surfactant / nonionic surfactant) is preferably 0.05 or more, more preferably 0.08 or more, and even more preferably 0.1 or more. The upper limit of (anionic surfactant / nonionic surfactant) is preferably 0.5 or less, more preferably 0.4 or less, even more preferably 0.3 or less, and even more preferably 0.2 or less. Within the above numerical range, the formation of precipitates at high temperatures can be further suppressed. Therefore, the ratio of the anionic surfactant to the nonionic surfactant in component (C) (anionic surfactant / nonionic surfactant) is preferably 0.05 to 0.5, more preferably 0.08 to 0.4, and even more preferably 0.1 to 0.3.

[0021] Examples of humectants include sugar alcohols such as sorbitol solution, maltitol, and lactite, and polyhydric alcohols such as glycerin, ethylene glycol, polyethylene glycol, and propylene glycol. When using these humectants, the amount of humectant can be appropriately determined within a range that does not impair the effects of the present invention.

[0022] Examples of sweeteners that can be blended include xylitol, maltitol, saccharin, saccharin sodium, stevioside, aspartame, p-methoxycinnamic aldehyde, etc. When a sweetener is used, the amount to be blended can be determined appropriately within a range that does not impair the effects of the present invention.

[0023] Examples of pH adjusters include citric acid, malic acid, lactic acid, tartaric acid, succinic acid, acetic acid, phosphoric acid, pyrophosphoric acid, glycerophosphoric acid, various salts thereof such as potassium salts, sodium salts and ammonium salts, sodium hydroxide, hydrochloric acid, etc. These can be blended alone or in combination of two or more so that the pH of the composition falls within the range of 5 to 9. When a pH adjuster is used, the blending amount can be determined appropriately within a range that does not impair the effects of the present invention.

[0024] Examples of preservatives include sodium benzoate, parahydroxybenzoic acid esters such as methylparaben, ethylparaben, and butylparaben, ethylenediaminetetraacetate, and benzalkonium chloride. These preservatives can be used singly or in combination of two or more. When a preservative is used, the amount of preservative added can be determined appropriately within a range that does not impair the effects of the present invention.

[0025] Examples of suspending agents include emulsions containing, in the oil phase, one or more oily components selected from olive oil, camellia oil, castor oil, and triglyceride fatty acid having 6 to 12 carbon atoms.

[0026] Examples of fragrances include peppermint oil, spearmint oil, mint oil, anise oil, eucalyptus oil, cassia oil, clove oil, thyme oil, sage oil, cardamom oil, coriander oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, orange oil, lemon oil, lime oil, grapefruit oil, mandarin oil, yuzu oil, wintergreen oil, mastic oil, lavender oil, and neroli oil (orange flower oil). Natural essential oils such as lemongrass oil, jasmine oil, rose oil, iris oil, vanilla oil, and paracles oil, and the above natural essential oils such as l-menthol, l-carvone, anethole, 1,8-cineole, methyl salicylate, cinnamic aldehyde, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spilanthol, and α-terpineol. Fragrance components contained in the oil, as well as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, p-methoxycinnamic aldehyde, cis-3-hexenol, trans-2-hexenal, methyl anthranilate, ethyl methylphenylglycidate, benzaldehyde, menthofuran, undecalactone, decalactone, hexyl acetate, ethyl 2-methylbutyrate, benzyl alcohol, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, methyl cinnamate, methylheptyne carbonate, ionone, ethyl-β-methylthiopropionate, cis-6-nonenol, calone, methyl jasmonate, maltol, ethyl maltol, vanillin, ethyl vanillin, furaneol, ethyl cyclopentenolone, 3-hydroxy-4,5-Dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetic acid, propionic acid, gamma / delta decalactone, gamma / delta decalactone, menthyl lactate, N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, N-[(ethoxycarbonyl)methyl]-p-menthane-3-carboxamide, Np-benzeneacetonitrile menthanecarboxamide, N-(2-(pyridin-2-yl)ethyl)-3-p-menthanecarboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide, 3-l-menthoxypropane- One or more of the following may be added to the composition within the scope of the present invention: fragrance components such as 1,2-diol, menthyl glyceryl ether, menthyl succinate, linalool oxide, vanillyl butyl ether, isopulegol, N-ethyl-p-menthane-3-carboxamide, and ethylene glycol-l-menthyl carbonate; plant extracts such as chili pepper extract, ginger extract, pepper extract, and Japanese pepper extract; blended flavors such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, and yogurt, which are made by combining several fragrance components and natural essential oils; and fragrance solvents such as ethyl alcohol, propylene glycol, triacetin, and glycerin fatty acid esters, within the scope of the present invention. When fragrances are used, the amount of addition can be determined appropriately within the scope of the present invention.

[0027] Examples of active ingredients that can be added include disinfectants such as isopropylmethylphenol and isopropylmethylcellulose, anti-inflammatory agents such as tranexamic acid and allantoin, enzymes such as dextranase and mutanase, fluorides such as sodium fluoride and sodium monofluorophosphate, vitamin Cs such as aluminum chlorohydroxyallantoin, azulene, lysozyme chloride and ascorbic acid, dihydrocholesterol, glycyrrhetinates, dihydrocholesterol, chlorophyll, copper chlorophyllin sodium, plant extracts such as thyme, Scutellaria Root, clove and witch hazel, copper gluconate, callopeptide, sodium polyphosphate, water-soluble inorganic phosphate compounds, polyvinylpyrrolidone, anti-tartar agents, anti-plaque agents, potassium nitrate, aluminum lactate, etc. The amount of these active ingredients added can be an effective amount within a range that does not interfere with the effects of the present invention.

[0028] Water is usually used as the solvent, and a lower monohydric alcohol such as ethanol may be added. If added, the amount is preferably 10% or less of the total composition, more preferably 8% or less, and even more preferably 5% or less.

[0029] The liquid oral composition of the present invention can be used in liquid products such as liquid toothpaste for regular tooth brushing, liquid toothpaste for interdental areas that is applied to interdental brushes or dental floss, topical products that are applied to the neck or gums of the teeth by applying them to sheets such as fingers or nonwoven fabrics, topical products that are administered directly to areas such as interdental areas or periodontal pockets using a container equipped with a fine nozzle, and concentrated mouthwashes and gargles that are diluted with water or other liquids before use.

[0030] The container for containing the liquid oral composition of the present invention is not particularly limited, and it can be filled into a container normally used for oral compositions.Specific examples of such containers include laminate containers made of a polyethylene layer, an ethylene methacrylic acid copolymer layer, a polyethylene terephthalate layer, an aluminum layer, a glass vapor deposition layer, a polyvinyl alcohol layer, an ethylene vinyl alcohol copolymer layer, an acrylonitrile copolymer layer, paper, a recycled plastic layer, etc., or polyethylene containers, polyethylene terephthalate containers, polypropylene containers, etc., and various containers normally used for oral compositions, such as tubular containers, mechanical or differential pressure dispenser containers, and film packaging containers such as pillow packaging, can also be used. [Example]

[0031] The present invention will be specifically explained below with reference to examples, comparative examples, and formulation examples, but the present invention is not limited to the following examples. In the following examples, % indicates % by mass unless otherwise specified. In the tables below, the unit of content is % by mass. Polyoxyethylene is abbreviated as POE. The numbers in parentheses for polyoxyethylene hydrogenated castor oil and polyoxyethylene cetyl ether are the average number of moles of ethylene oxide added.

[0032] [Examples 1 to 18, Comparative Examples 1 to 6] Liquid oral compositions (mouthwashes) having the compositions shown in Tables 1 to 3 were prepared by a conventional method and evaluated by the following methods. The results are shown in Tables 1 to 3.

[0033] Details of the raw materials used are as follows: [Component (A)] Dipotassium glycyrrhizinate: Dipotassium glycyrrhizinate, manufactured by Maruzen Pharmaceutical Co., Ltd. Monoammonium glycyrrhizinate: Monoammonium glycyrrhizinate, manufactured by Maruzen Pharmaceutical Co., Ltd. [(B) Component] Tocopherol acetate: Tocopherol acetate, manufactured by DSM Co., Ltd. [Component (C)] () indicates the average number of moles of ethylene oxide (EO) added Sodium lauryl sulfate: Texapon (registered trademark) OC-P, manufactured by BASF Sodium lauroyl methyl taurate: Nikko Chemicals Co., Ltd., LMT-P POE hydrogenated castor oil (60): HCO-60, manufactured by Nippon Surfactant Industries Co., Ltd. POE hydrogenated castor oil (100): EMALEX HC-100, manufactured by Nippon Emulsion Co., Ltd. POE cetyl ether (15): Aoki Oil & Fat Industries Co., Ltd., Brownon CH-315L Polyoxyethylene sorbitan monostearate: Rheodor TW-S120V, manufactured by Kao Corporation [Fragrance] Fragrance composition A as described in Table 4 below. [water] Purified water.

[0034] (1) Retention of the formulation An expert panelist placed 10 ml of the liquid oral composition having the composition shown in Tables 1 to 3 in the mouth, rinsed for 30 seconds, and spat out the composition. The feeling of the composition remaining in the mouth immediately afterwards was evaluated according to the following evaluation criteria. Criteria for determining the feeling of stagnation; ◎: I felt it very much 〇: I felt it △: I didn't feel much ×: Didn't feel

[0035] (2) Evaluation method for usability An expert panelist took 10 ml of the liquid oral composition having the composition shown in Tables 1 to 3 into their mouths, rinsed for 30 seconds, and then spat it out. Immediately afterwards, the unpleasant feeling remaining in the mouth was evaluated according to the following evaluation criteria. ◎: Didn't feel it 〇: I didn't feel much △: I felt it ×: I felt it very much

[0036] (3) Evaluation method for the presence or absence of precipitates after storage at high temperatures 50 ml of liquid oral composition having the composition shown in Tables 1 to 3 was filled into a hard glass container (SV-50A, manufactured by Nichiden Rika Glass Co., Ltd.) and stored in a 70°C thermostatic chamber for one week. After that, the presence or absence of precipitates was visually evaluated according to the following evaluation criteria. ◎: No precipitate was observed in the composition ○: Precipitation was observed in the composition, but it was at a level that was not problematic. △: Some precipitates were observed in the composition ×: A considerable amount of precipitate was observed in the composition.

[0037] [Table 1]

[0038] [Table 2]

[0039] [Table 3]

[0040] As shown in the above results, the liquid oral compositions of Examples 1 to 18 were rated "○" or "◎" in terms of the retention of the preparation, the feel when used, and the presence or absence of precipitates after high-temperature storage.

[0041] (Prescription example) Below are examples of formulations of liquid oral compositions to which the present invention is applied. In each example, "%" indicating the content is "% by mass." In the following formulation examples 1 to 8, the retention and feel of the preparation were good, and the occurrence of precipitates at high temperatures was suppressed.

[0042] [Prescription Example 1] Mouthwash (A) Dipotassium glycyrrhizinate 0.1% (B) Tocopherol acetate 0.04% (C) Sodium lauryl sulfate 0.09% (C) POE hydrogenated castor oil (60) 0.3% Propylene glycol 2.5% Glycerin (85% aqueous solution) 2.5% Ethanol 4% Xylitol 3% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Refined water residue Total 100%

[0043] [Prescription Example 2] Mouthwash (A) Dipotassium glycyrrhizinate 0.08% (B) Tocopherol acetate 0.08% (C) Sodium lauryl sulfate 0.09% (C) POE hydrogenated castor oil (60) 0.3% Propylene glycol 2.5% Glycerin (85% aqueous solution) 2.5% Sodium saccharin 0.005% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Refined water residue Total 100%

[0044] [Prescription Example 3] Mouthwash (A) Dipotassium glycyrrhizinate 0.1% (B) Tocopherol acetate 0.04% (C) Sodium lauryl sulfate 0.09% (C) POE hydrogenated castor oil (60) 0.3% Isopropylmethylphenol 0.1% Tranexamic acid 0.1% Propylene glycol 2.5% Glycerin (85% aqueous solution) 2.5% Ethanol 4% Xylitol 3% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Refined water residue Total 100%

[0045] [Prescription Example 4] Mouthwash (A) Dipotassium glycyrrhizinate 0.06% (B) Tocopherol acetate 0.04% (C) Sodium lauryl sulfate 0.09% (C) POE hydrogenated castor oil (100) 0.3% Isopropylmethylphenol 0.1% Tranexamic acid 0.1% Propylene glycol 2.5% Glycerin (85% aqueous solution) 2.5% Ethanol 4% Xylitol 3% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Refined water residue Total 100%

[0046] [Prescription Example 5] Mouthwash (A) Dipotassium glycyrrhizinate 0.06% (B) Tocopherol acetate 0.04% (C) Sodium lauryl sulfate 0.09% (C) POE hydrogenated castor oil (100) 0.3% Isopropylmethylphenol 0.1% Tranexamic acid 0.1% Propylene glycol 2.5% Glycerin (85% aqueous solution) 4.0% Ethanol 4% Sorbitol (70%) 3% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Refined water residue Total 100%

[0047] [Prescription Example 6] Mouthwash (A) Dipotassium glycyrrhizinate 0.07% (B) Tocopherol acetate 0.04% (C) Sodium lauryl sulfate 0.09% (C) POE hydrogenated castor oil (60) 0.3% Propylene glycol 2.5% Glycerin (85% aqueous solution) 2.5% Sorbitol (70% aqueous solution) 5% Ethanol 4% Xylitol 3% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition B 0.4% Refined water residue Total 100%

[0048] [Prescription Example 7] Mouthwash (A) Dipotassium glycyrrhizinate 0.1% (B) Tocopherol acetate 0.04% (C) Sodium lauroyl methyl taurate 0.11% (C) POE hydrogenated castor oil (60) 0.3% Tranexamic acid 0.1% Propylene glycol 5.0% Glycerin (85% aqueous solution) 2.5% Ethanol 4% Xylitol 3% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Refined water residue Total 100%

[0049] [Prescription Example 8] Mouthwash (A) Dipotassium glycyrrhizinate 0.1% (B) Tocopherol acetate 0.04% (C) Sodium lauroyl methyl taurate 0.11% (C) POE hydrogenated castor oil (60) 0.3% Isopropylmethylphenol 0.07% Propylene glycol 5.0% Glycerin (85% aqueous solution) 2.5% Sodium saccharin 0.005% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Refined water residue Total 100%

[0050] Furthermore, mouthwashes were prepared with the same composition as in Examples 1 to 18 and Formulation Examples 1 to 8 above, except that fragrance composition A or fragrance composition B was replaced with fragrance compositions B to P or A or C to P listed in Tables 4 to 6 below, respectively.All of these had a good feel when used, suppressed the formation of precipitates at high temperatures, and reduced unpleasant taste. The compositions of flavors 1 to 7 and solvents described in Tables 4 to 6 are shown in Tables 7 to 14. In the table, "cut a% of the front end" means that the first a% is removed when the essential oil is distilled, and "cut b% of the front and back ends" means that the first b% and the last b% are removed when the essential oil is distilled.

[0051] [Table 4]

[0052] [Table 5]

[0053] [Table 6]

[0054] Table 7

[0055] Table 8

[0056] Table 9

[0057] Table 10

[0058] Table 11

[0059] Table 12

[0060] Table 13

[0061] Table 14

Claims

1. (A) glycyrrhizinic acid or a salt thereof; and (B) vitamin E, 0.05 to 0.20 mass% of component (A), 0.01 to 1 mass% of component (B), and Moisture content: 45 to 90% by mass A liquid oral composition containing

2. A liquid oral composition as described in claim 1, further containing (C) at least one surfactant selected from a nonionic surfactant and an anionic surfactant.

3. A liquid oral composition as described in claim 2, containing 0.2 to 2% by weight of component (C).

4. A liquid oral composition described in any one of claims 1 to 3, wherein the mass ratio of (A) / (B) is 1 or more.

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