Oral composition

Abstract

An object of the present invention is to provide an oral composition having a good antibacterial effect, flavor expression, and smooth skin.SOLUTION: A composition for oral cavity, a dentifrice composition, a composition for external use, and a composition for oral cavity for treatment or prevention of periodontal disease, comprising a component (A): a fluorine-containing compound, a component (B): hinokitiol and / or thymol, and a component (C): a nonionic surfactant, wherein the content of the component (A) is 3000 to 20000 ppm in terms of fluoride ion concentration.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oral composition. [Background technology]

[0002] Periodontal disease is caused by an infectious disease caused by bacteria such as Porphyromonas gingivalis. Therefore, plaque control, i.e., keeping the number of pathogenic bacteria in the oral cavity at a low level, is said to be an effective means of preventing and improving oral diseases. Antibacterial activity and the inhibition of plaque formation are important means of reducing the number of pathogenic bacteria in the oral cavity. Hinokitiol is known to exhibit a broad antibacterial spectrum and high antibacterial effect (Patent Documents 1 and 2).

[0003] Patent Document 3 describes a dentifrice composition containing a nonionic bactericide such as hinokitiol, one or more selected from triacylglycerol, vegetable oil, and animal oil, and a nonionic surfactant, which prevents the nonionic bactericide from adsorbing to the container and maintains stability over time, and which is non-irritating and pleasant to use. Patent Document 4 describes a foam-type oral composition that foams well and contains a hydrophobic active ingredient such as hinokitiol, one or more selected from anionic surfactants and amphoteric surfactants, a polyoxyethylene alkyl ether, and a water-soluble polymer. Patent Document 5 describes an oral composition for hypersensitive teeth that contains ethanol, a water-soluble nonionic surfactant, hinokitiol, and a water-soluble aluminum compound. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2015-127305 A [Patent Document 2] Japanese Patent Application Laid-Open No. 2018-058795 [Patent Document 3] Japanese Patent Application Laid-Open No. 2023-083626 [Patent Document 4] Japanese Patent Application Laid-Open No. 2023-050745 [Patent Document 5] Japanese Patent Application Laid-Open No. 2003-212743 Summary of the Invention [Problem to be solved by the invention]

[0005] However, increasing the concentration of hinokitiol can lead to a stronger hiba-like flavor, which can impair the flavor of the oral composition, while incorporating a high concentration of fluoride can lead to poor surface texture of the composition.

[0006] We have found that adding a fluoride such as sodium fluoride in an amount equivalent to 3,000 to 20,000 ppm (calculated as a fluoride ion concentration) can suppress the hiba (Japanese cypress) flavor characteristic of hinokitiol and other flavors of thymol. Furthermore, we have found that adding a nonionic surfactant improves the texture of the product and further suppresses the flavors of hinokitiol and other ingredients.

[0007] An object of the present invention is to provide an oral composition that has good antibacterial effect, flavor expression, and smooth surface. [Means for solving the problem]

[0008] The present invention provides the following [1] to

[10] . [1] An oral composition comprising component (A): a fluorine-containing compound, and component (B): at least one of hinokitiol and thymol, wherein the content of component (A) is in an amount equivalent to 3,000 to 20,000 ppm when converted into a fluoride ion concentration. [2] The oral composition according to [1], wherein component (A) is one or more selected from the group consisting of sodium fluoride, sodium monofluorophosphate, and stannous fluoride. [3] The oral composition according to [1] or [2], further comprising component (C): a nonionic surfactant. [4] The oral composition according to any one of [1] to [3], wherein the content of component (A) is an amount equivalent to 4000 to 15000 ppm in terms of fluoride ion concentration. [5] The oral composition described in [3], wherein component (C) is one or more selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid esters, sucrose fatty acid esters, maltose fatty acid esters, sugar alcohol fatty acid esters, alkylolamides, polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene glycol fatty acid esters, polyethylene glycol fatty acid esters, polyoxyethylene polyoxypropylene glycol, fatty acid diethanolamides, polyoxyethylene alkyl ethers, and polyoxyethylene alkyl phenyl ethers. [6] The oral composition according to any one of [1] to [5], wherein the ratio (A) / (B) of the fluoride ion concentration corresponding to the content of component (A) to the content of component (B) is 15,000 to 950,000. [7] The oral composition according to any one of [1] to [6], which is a dentifrice composition. [8] The oral composition according to any one of [1] to [6], which is an external preparation composition. [9] The oral composition according to claim 1 or 2, which is for treating or preventing periodontal disease.

[10] A periodontal disease treatment or prevention agent comprising component (A): a fluorine-containing compound, and component (B): at least one of hinokitiol and thymol, wherein the content of component (A) is an amount equivalent to 3,000 to 20,000 ppm when converted into a fluoride ion concentration. [Effects of the Invention]

[0009] According to the present invention, an oral composition having good antibacterial effect, flavor expression, and smooth surface can be provided. DETAILED DESCRIPTION OF THE INVENTION

[0010] [1. Oral composition] The oral composition of the present invention contains the following component (A) and component (B), and more preferably further contains the following component (C).

[0011] [Component (A)] Component (A) is a fluorine-containing compound. By including component (A), the oral composition can exhibit a flavor improving effect.

[0012] Examples of fluorine-containing compounds include alkali metal fluorides, metal fluorides, monofluorophosphates, and salts thereof. Among these, one or more compounds selected from sodium fluoride, sodium monofluorophosphate, and stannous fluoride are preferred, and sodium fluoride is more preferred.

[0013] The content of component (A), when converted into fluoride ion concentration relative to the total amount of the composition, is preferably 3000 ppm or more, more preferably 4000 ppm or more. This ensures sufficient flavor improvement of the oral composition. The upper limit is preferably 20000 ppm or less, more preferably 15000 ppm or less. This prevents deterioration of the kneaded surface and flavor expression. Therefore, the content of component (A), when converted into fluoride ion concentration relative to the total amount of the composition, is preferably 3000 to 20000 ppm, more preferably 4000 to 15000 ppm.

[0014] The suitable content of component (A) varies depending on the selected fluorine-containing compound. Specifically, for example, when component (A) is sodium fluoride, it is preferably 0.6% by mass or more, more preferably 0.8% by mass or more, based on the total amount of the composition. The upper limit is preferably 4.5% by mass or less, more preferably 3.4% by mass or less. Therefore, it is preferably 0.6 to 4.5% by mass, more preferably 0.8 to 3.4% by mass.

[0015] Furthermore, for example, when component (A) is sodium monofluorophosphate, the content of sodium monofluorophosphate is preferably 2.2% by mass or more, more preferably 3.0% by mass or more, based on the total amount of the composition. The upper limit is preferably 15.2% by mass or less, more preferably 11.4% by mass or less. Therefore, it is preferably 2.2 to 15.2% by mass, more preferably 3.0 to 11.4% by mass.

[0016] Furthermore, for example, when component (A) is stannous fluoride, the content of stannous fluoride is preferably 1.2 mass% or more, more preferably 1.6 mass% or more, based on the total amount of the composition. The upper limit is preferably 8.3 mass% or less, more preferably 6.2 mass% or less. Therefore, it is preferably 1.2 to 8.3 mass%, more preferably 1.6 to 6.2 mass%.

[0017] When the content (% by mass) of each component (A) satisfies the above-mentioned numerical range, the content (ppm) of component (A) converted into fluorine ion concentration satisfies the above-mentioned numerical range, and the effects of the present invention can be more suitably exhibited.

[0018] [Component (B)] Component (B) is one or more selected from the group consisting of hinokitiol and thymol. By including component (B), an antibacterial effect can be exerted.

[0019] Hinokitiol may be, for example, hinokitiol, its derivatives, or salts thereof (such as sodium salts). Hinokitiol is represented by the chemical formula C 10 H 12Hinokitiol is an aromatic compound represented by the formula O2. Methods for producing hinokitiol include, but are not limited to, obtaining it from oil obtained by distilling the wood or roots of Taiwan cypress or Aomori cypress. Examples of hinokitiol include hinokitiol, its salts, metal complexes, and combinations of two or more selected from these. Hinokitiol may be used alone or in combination with two or more types obtained from different raw materials or different production methods, but hinokitiol is preferred from the viewpoint of achieving the desired effects of the present invention.

[0020] Hinokitiol that meets the specifications for "Hinokitiol" in the Quasi-drug Raw Materials Standards 2021 can usually be used; for example, a commercially available product (Hinokitiol, manufactured by Takasago International) that is specified as having a purity of 98% or more can be used.

[0021] Thymol may be, for example, thymol, thymol derivatives, or salts thereof (e.g., thymol chloride, thymol bromide, thymol iodide). Of these, thymol is preferred. Thymol (5-methyl-2-(1-methylethyl)phenol) is a compound represented by the chemical formula C 10 H 14 Thymol is an aromatic compound represented by the formula O. Methods for producing thymol include, but are not limited to, distillation or extraction from the above-ground parts of plants such as Japanese perilla and thyme. Thymol that meets the specifications set forth in the 18th edition of the Japanese Pharmacopoeia, "Thymol," can be used, and for example, a commercially available product manufactured by Kanto Chemical Co., Ltd. may be used. Furthermore, thymol may be used alone or in combination of two or more types made from different raw materials or produced by different methods.

[0022] The content of component (B) is preferably 0.005% by mass or more, more preferably 0.008% by mass or more, and even more preferably 0.08% by mass or more, based on the total amount of the composition. This is more preferable because it allows the oral composition to fully exert its antibacterial activity. The upper limit is preferably 0.5% by mass or less, more preferably 0.3% by mass or less, and even more preferably 0.15% by mass or less. This further prevents the deterioration of flavor expression due to the unique flavor of component (B). Therefore, the content of component (B) is preferably 0.005 to 0.5% by mass, more preferably 0.008 to 0.3% by mass, and even more preferably 0.08 to 0.15% by mass, based on the total amount of the composition.

[0023] [(A) / (B)] The ratio (A) / (B) is the ratio of the fluoride ion concentration (ppm) corresponding to the content of component (A) to the content (% by mass) of component (B) in the composition. When (A) / (B) satisfies the following numerical range, the oral composition of the present invention can more suitably exhibit its flavor improving effect.

[0024] (A) / (B) is preferably 15,000 or more, more preferably 18,000 or more, even more preferably 20,000 or more, or 40,000 or more. This is more preferable because it can sufficiently improve the flavor of the oral composition. The upper limit is preferably 950,000 or less, or 600,000 or less, more preferably 500,000 or less, and even more preferably 200,000 or less, or 150,000 or less. This allows the oral composition to more effectively exhibit flavor. Therefore, (A) / (B) is preferably 15,000 to 950,000, or 15,000 to 600,000, more preferably 18,000 to 500,000, and even more preferably 20,000 to 200,000, or 40,000 to 150,000.

[0025] [Component (C)] Component (C) is a nonionic surfactant. By including component (C), the oral composition can be further improved in terms of surface smoothness.

[0026] Preferred nonionic surfactants include sugar alcohol fatty acid esters such as polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid esters, sucrose fatty acid esters, maltose fatty acid esters, maltitol fatty acid esters, and lactol fatty acid esters; alkylolamides, polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene glycol fatty acid esters, polyethylene glycol fatty acid esters, polyoxyethylene polyoxypropylene glycol, fatty acid diethanolamides such as lauric acid mono- or diethanolamide, polyoxyethylene alkyl ethers, and polyoxyethylene alkylphenyl ethers; more preferred are polyoxyethylene hydrogenated castor oil, sucrose fatty acid esters, polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, polyglycerin fatty acid esters, and polyoxyethylene alkyl ethers; and even more preferred are sucrose fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and sorbitan fatty acid esters.

[0027] The sucrose fatty acid ester is preferably a sucrose fatty acid ester derived from a fatty acid having 8 to 20 carbon atoms, more preferably a sucrose fatty acid ester derived from a fatty acid having 10 to 18 carbon atoms. Of these, sucrose laurate is preferred. The proportion of sucrose fatty acid monoesters (compounds in which one fatty acid is ester-bonded to sucrose) in the sucrose fatty acid esters is preferably 50 mol % or more, more preferably 70 mol % or more. There is no particular upper limit, as long as it is 100 mol % or less.

[0028] The polyoxyethylene sorbitan fatty acid ester is preferably a polyoxyethylene sorbitan fatty acid ester derived from a fatty acid having 10 to 22 carbon atoms, and more preferably a polyoxyethylene sorbitan fatty acid ester derived from a fatty acid having 14 to 20 carbon atoms. Of these, polyoxyethylene sorbitan monostearate fatty acid ester (polyoxyethylene sorbitan monostearate) is preferred. The average number of moles of ethylene oxide (hereinafter also referred to as "EO") added in the polyoxyethylene sorbitan fatty acid ester is preferably 5 to 30 moles, more preferably 10 to 25 moles.

[0029] The sorbitan fatty acid ester is preferably a polyoxyethylene sorbitan fatty acid ester derived from a fatty acid having 10 to 22 carbon atoms, more preferably a polyoxyethylene sorbitan fatty acid ester derived from a fatty acid having 14 to 20 carbon atoms. Of these, sorbitan monostearate is preferred.

[0030] The polyglycerol fatty acid ester is preferably a glycerol fatty acid ester derived from a fatty acid having 8 to 20 carbon atoms, more preferably a glycerol fatty acid ester derived from a fatty acid having 10 to 18 carbon atoms. As such a fatty acid ester, polyglyceryl monolaurate is preferred. The polyglycerin is preferably a dimer to dodecamer, more preferably a trimer to dodecamer. Of these, decaglyceryl laurate is more preferred as the polyglycerol fatty acid ester.

[0031] The polyoxyethylene alkyl ether preferably has 10 to 24 carbon atoms in the alkyl group, more preferably 16 to 20 carbon atoms. The average number of moles of EO added in the polyoxyethylene alkyl ether is preferably 2 to 30 moles, more preferably 5 to 22 moles. Of these, polyoxyethylene stearyl ether is preferred.

[0032] The content of component (C) is preferably 0.5% by mass or more, more preferably 0.6% by mass or more, based on the total amount of the composition. This results in a better kneaded surface of the oral composition. The upper limit is preferably 4.0% by mass or less, more preferably 3.0% by mass or less, or 2.5% by mass or less. This allows the oral composition to exhibit better antibacterial activity. Therefore, the content of component (C) is preferably 0.5 to 4.0% by mass, more preferably 0.6 to 3.0% by mass, or 0.6 to 2.5% by mass, based on the total amount of the composition.

[0033] [Optional ingredients] The oral composition may contain optional ingredients other than the above ingredients (A) to (C) depending on the intended use, dosage form, etc., as long as the ingredients do not impair the effects of the present invention. Specifically, surfactants, abrasives, binders, humectants, and, if necessary, pH adjusters, sweeteners, preservatives, colorants, flavorings, various medicinal ingredients, oily ingredients, etc. may be added.

[0034] -Surfactants- As the surfactant, surfactants other than the above-mentioned component (C), that is, at least one selected from anionic surfactants and zwitterionic surfactants, can be used.

[0035] (anionic surfactants) Examples of anionic surfactants include alkyl sulfates, α-olefin sulfonates, N-acylsulfonates, sulfates of glycerin fatty acid esters, acylamino acids, and acyltaurines. The alkyl and acyl groups may be linear or branched, saturated or unsaturated, and typically contain 10 to 20 carbon atoms, preferably 12 to 18, and more preferably 12 to 14 carbon atoms. The salts may be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include base addition salts and amino acid salts. Specific examples include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts.

[0036] Examples of alkyl sulfates include lauryl sulfate and myristoyl sulfate. Examples of α-olefin sulfonates include α-olefin sulfonates having 12 to 18 carbon atoms, such as tetradecene sulfonate.

[0037] Examples of acyl amino acids include lauroyl sarcosine salts and lauroyl glutamate salts, and examples of acyltaurine salts include lauroyl methyl taurine salts.

[0038] Other examples of anionic surfactants include, for example, sodium hydrogenated coconut fatty acid monoglyceride monosulfate and sodium lauryl sulfoacetate.

[0039] (zwitterionic surfactants) Examples of zwitterionic surfactants include N-alkyldiaminoethylglycines such as N-lauryldiaminoethylglycine and N-myristyldiaminoethylglycine; betaine-type amphoteric surfactants such as N-alkyl N-carboxymethylammonium betaine, 2-alkyl-1-hydroxyethylimidazoline betaine sodium, alkyldimethylaminoacetic acid betaine (e.g., lauryldimethylaminoacetic acid betaine), and fatty acid amidopropyldimethylaminoacetic acid betaine (e.g., cocamidopropyl betaine); imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts (e.g., N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine), coconut oil fatty acid imidazolinium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine; and alkyl betaines such as lauryldimethylaminoacetic acid betaine.

[0040] The amount of these surfactants added is usually 0.001 to 10% by mass, preferably 0.1 to 5% by mass, and more preferably 0.5 to 3% by mass, relative to the total amount of the composition.

[0041] -Abrasives- The abrasive may be either inorganic or organic. Examples of inorganic abrasives include abrasive silica such as precipitated silica, crystalline silica, amorphous silica, silica gel, aluminosilicate, zirconosilicate, and titanium-bonded silica; zeolite; calcium phosphate compounds such as anhydrous calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate, calcium pyrophosphate, dibasic calcium phosphate dihydrate or anhydrous calcium phosphate, monobasic calcium phosphate, tribasic calcium phosphate, and tetrabasic calcium phosphate; calcium carbonate abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, calcium sulfate, bentonite, zirconium silicate, and hydroxyapatite. Examples of organic abrasives include synthetic resin abrasives. The amount of abrasive blended is preferably 7% by mass or more, more preferably 10% by mass or more, and preferably 50% by mass or less, more preferably 30% by mass or less, preferably 7% by mass to 50% by mass, and more preferably 10% by mass to 30% by mass, based on the total amount of the composition.

[0042] -Binder- Examples of binders include polysaccharide thickeners (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, gum arabic, locust bean gum, carrageenan, sodium alginate), cellulose binders (e.g., hypromellose, carboxymethylcellulose (CMC), hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethylcellulose, methylcellulose, cationized cellulose, and pharmacologically acceptable salts thereof, such as sodium salts), and synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate). Furthermore, inorganic binders such as thickening silica and aluminum silicate can also be added.

[0043] When a binder is contained, the content thereof is usually 10% by mass or less, preferably 0.1 to 10% by mass, and more preferably 1 to 8% by mass, based on the total amount of the composition.

[0044] -Wetting agent- As the humectant, sugar alcohols and polyhydric alcohols other than sugar alcohols are preferred. Examples of sugar alcohols include sugar alcohols such as sorbitol, xylitol, erythritol, maltitol, lactitol, and reduced starch saccharification products; and polyhydric alcohols such as glycerin, ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. Examples of polyethylene glycols include polyethylene glycols having an average molecular weight of 150 to 6000, and preferably polyethylene glycols having an average molecular weight of 100 to 4500, 100 to 3000, 150 to 1000, or 190 to 630. Specific examples include PEG200, PEG300, PEG400, PEG600, and PEG4000. The content of the wetting agent is usually 40% by mass or less, preferably 0.1 to 30% by mass, or 1 to 30% by mass, based on the total amount of the composition. The average molecular weight is the average molecular weight described in the Quasi-drug Raw Materials Standards 2021.

[0045] - pH adjuster - Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (e.g., sodium citrate), inorganic acids such as phosphoric acid (e.g., orthophosphoric acid), or their salts (e.g., potassium salts, sodium salts, and ammonium salts), and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic acid salts include disodium hydrogen phosphate and sodium dihydrogen phosphate. The content of the pH adjuster can usually be set to an amount that will give the oral composition a pH of 5.0 to 9.0 after addition, and preferably an amount that will give the oral composition a pH of 6.0 to 8.5.

[0046] In this specification, the pH value generally refers to the value measured 3 minutes after the start of measurement at 25° C. The pH value can be measured, for example, using a pH meter (model number Hm-30S) manufactured by Toa Dempa Kogyo Co., Ltd.

[0047] -Sweetener- Examples of sweeteners include saccharin, saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, thaumatin, and aspartylphenylalanine methyl ester. The sweeteners may be used singly or in combination of two or more of the above-listed sweeteners.

[0048] -Preservatives- Examples of preservatives include benzoates such as sodium benzoate, and parahydroxybenzoic acid esters such as methyl parahydroxybenzoate (methylparaben), ethyl parahydroxybenzoate (ethylparaben), and butyl parahydroxybenzoate (butylparaben). One type of preservative may be used alone, or two or more types may be used in combination.

[0049] -Coloring agent- Examples of colorants include natural dyes such as safflower red, gardenia yellow, gardenia blue, perilla color, red koji color, red cabbage color, carrot color, hibiscus color, cacao color, spirulina blue, and tamarind color, as well as legally designated dyes such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1, riboflavin, sodium copper chlorophine, and titanium dioxide (titanium oxide). When the oral composition contains a colorant, the content thereof is preferably 0.00001 to 3% by mass of the total amount of the composition.

[0050] Examples of fragrances include peppermint oil, spearmint oil, Japanese peppermint oil, anise oil, cassia oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange flower oil), lemongrass oil, jasmine oil, rose oil, iris oil, clove oil, thyme oil, sage oil, coriander oil, cardamom oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, lime oil, mandarin oil, yuzu oil, nutmeg oil, lavender oil, paracles oil, vanilla oil, cinnamon oil, and pime Natural essential oils such as menthol oil, cinnamon leaf oil, perilla oil, and wintergreen oil; fragrance components contained in the above natural essential oils such as menthol, menthofuran, carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate, eugenol, linalool, limonene, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spilanthol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, ethyl linalool, vanillin, and methyl jasmonate;Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenylglycidate, benzaldehyde, ethyl vanillin, furaneol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), menthyl lactate, ethylene glycol-l-menthyl carbonate, maltol, ethyl maltol, linalool oxide, vanillyl butyl ether, ethyl cyclopentenolone, 3-hydroxy-4,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, 2-methylbutyric acid Fragrance ingredients such as acetic acid, propionic acid, cis-3-hexenol, trans-2-hexenol, undecalactone, decalactone, hexyl acetate, ethyl 2-methylbutyrate, benzyl alcohol, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, methyl cinnamate, methylheptyne carbonate, ionone, ethyl beta-methylthiopropionate, cis-6-nonenol, and 7-methyl-3,5-dihydro-2H-benzodioxepin-3-one; plant extracts such as chili pepper extract, ginger extract, pepper extract, and Japanese pepper extract;and various blended flavors such as mint, fruit, and herb flavors that are made by combining several fragrance ingredients and natural essential oils.Fragrances that can also function as cooling agents include, for example, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), N-[(ethoxycarbonyl)methyl)-p-menthane-3-carboxamide, Np-benzenesulfonylmenthanecarboxamide, N-(2-(pyridin-2-yl)ethyl)-3-p-menthanecarboxamide, menthyl lactate, menthyl monosuccinate, menthyl glyceryl ether, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylsilyl Other examples include cyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazol-yl)-N-(thiophen-2-ylmethyl)acetamide, isopulegol, menthone glycerol ketal, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, 3-l-menthoxypropane-1,2-diol, 5-methyl-2-propan-2-yl-N-(2-pyridin-2-ylethyl)cyclohexane-1-carboxamide, ethyl 3-(p-menthane-3-carboxamide)acetate, and 2-isopropyl-N,2,3-trimethylbutyramide. The fragrances listed above may be used alone or in combination of two or more. A solvent may be used when compounding these fragrances, such as ethanol, propylene glycol, glycerin fatty acid esters, and triacetin. When the oral composition contains a flavor, the content thereof is usually 0.000001 to 1% by mass, and preferably 0.01 to 1% by mass, based on the total amount of the composition. When the oral composition contains a flavor that can also function as a cooling agent, the content thereof is preferably 0.00001 to 0.01% by mass, based on the total amount of the composition.

[0051] -Medicinal ingredients- As the medicinal ingredient, ingredients other than the above-mentioned ingredient (A) and ingredient (B) can be used, for example, bactericidal or antibacterial agents such as isopropylmethylphenol, lysozyme chloride, chlorhexidine, triclosan, cetylpyridinium chloride (including hydrate), benzethonium chloride, benzalkonium chloride, zinc gluconate, zinc citrate, etc.; anti-tartar agents such as zeolite, ethanehydroxydiphosphonate, polyphosphates, etc.; tranexamic acid, glycyrrhizic acid or a salt thereof (e.g., dipotassium glycyrrhizinate), glycyrrhetinic acid or a salt thereof (e.g., stearyl glycyrrhetinate), allantoin, allantoin chlorohydroxyaluminum, ε-aminocaproic acid, and azulene; enzymes such as dextranase, amylase, protease, mutanase, and lysozyme chloride; vitamins such as vitamin C (e.g., ascorbic acid), vitamin E (e.g., tocopherol acetate, tocopherol nicotinate, tocopherol), panthenol, and pyridoxine; blood circulation promoters such as vitamin E; astringents such as sodium chloride, alum, and lysozyme chloride; hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; cell activators such as sodium chloride and vitamins; water-soluble copper compounds such as copper chlorophyll and copper gluconate; amino acids such as alanine, glycine, and proline; and peptides such as callopeptides. When the oral composition contains a medicinal ingredient, the amount of the ingredient can be within a range that does not interfere with the effects of the present invention (a pharmaceutically acceptable range).

[0052] -Oil-based ingredients- Examples of oily components include hydrocarbons such as squalane, (light) liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols having 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids having 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid), vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate.

[0053] -Other optional ingredients- The oral composition of the present embodiment may contain any suitable amount of optional components other than those described above.

[0054] In this embodiment, examples of other optional components that may be included in the oral composition include inorganic compounds such as titanium mica, titanium oxide, zinc oxide, magnesium oxide, and zirconium oxide; natural polymer compounds such as agar, gelatin, starch, and glucomannan; synthetic polymer compounds or copolymers thereof such as polyvinyl acetate, acrylic resin, polyurethane, polyester, polyvinyl chloride, nylon powder, and polyethylene powder; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetanol and stearyl alcohol; disintegrants such as povidone; solvents such as ethanol; polyisobutylene, polybutadiene, urethane, silicone, and natural rubber. The content of these other optional components can be appropriately set within a range that does not interfere with the effects of the present invention.

[0055] [2. Dosage Form] The oral composition of the present invention can be administered, for example, orally (e.g., internally), sublingually, or parenterally (e.g., transdermal mucosal administration, subcutaneous administration). Of these, oral administration and transdermal mucosal administration (external application) are preferred because they are less invasive, with oral administration and oral mucosal administration being more preferred, and oral preparations and external preparations (e.g., external gingival preparations) being even more preferred.

[0056] [3. Uses and dosage forms of oral compositions] The dosage form of the oral composition can be appropriately selected depending on the application form and is not particularly limited. Examples include liquids (liquids such as solutions, emulsions, suspensions, syrups, etc.), semi-solids (gels, creams, pastes, etc.), and solids (tablets, particulates, capsules, films, kneaded materials, molten solids, waxy solids, elastic solids, soft capsules, etc.). Among these, semi-solid forms are preferred. The oral composition of the present invention can be used in solid dosage forms such as lozenges, gummies, chewing gum, and dentifrices. Its semi-solid dosage forms can be used in toothpaste and gel dentifrices. Its liquid dosage forms can be used in mouthwashes, liquid dentifrices (liquid dentifrices), and mouth fresheners (sprays, etc.). Among these, dentifrices are preferred. As dentifrices, toothpaste and gel dentifrices are preferred.

[0057] -External application composition- The oral composition of the present invention can also be used as an external preparation composition. The dosage form of the external preparation composition can be, for example, a liquid (a liquid such as a solution, emulsion, suspension, or syrup) or a semi-solid (a gel, cream, or paste), with a semi-solid being preferred.

[0058] The topical composition can be prepared as a liniment, preferably as an ointment. The production method is not particularly limited, and a conventional method can be used depending on the dosage form. The topical composition is usually applied to the oral cavity, preferably the oral mucosa, gingiva, and gums.

[0059] -Oral composition for treating or preventing periodontal disease, and agent for treating or preventing periodontal disease- The oral composition of the present invention has an excellent antibacterial effect and is therefore useful for the treatment or prevention of periodontal disease (e.g., treatment, improvement, and alleviation of symptoms of periodontal disease) and can be used as a therapeutic or preventive agent for periodontal disease. Furthermore, alveolar pyorrhea is a type of periodontal disease. Therefore, the oral composition of the present invention is useful for the treatment or prevention of alveolar pyorrhea and can be used as a therapeutic or preventive agent for periodontal disease.

[0060] [4. Manufacturing Method and Properties of Oral Compositions] The method for producing the oral composition is not particularly limited, and it can be prepared by any conventional method depending on the dosage form. For example, when used as a toothpaste, a method can be used in which the components soluble in a solvent are prepared, and then the other insoluble components are mixed, and degassing (e.g., reduced pressure, etc.) is performed as necessary. The obtained toothpaste can be placed in a container to make a product. The shape and material of the container are not particularly limited, and containers used for conventional toothpaste compositions can be used, such as containers such as laminated tubes made of plastics such as polyethylene, polypropylene, polyethylene terephthalate, and nylon.

[0061] In this embodiment, the oral composition preferably has a pH (25° C.) of 5.0 to 9.0. The pH can be adjusted by adding a pH adjuster, adjusting the component composition, and the like.

[0062] The viscosity of the oral composition of this embodiment can be adjusted appropriately depending on the dosage form, for example. When the oral composition is in paste or gel form, the viscosity at 25°C measured with a BH viscometer is preferably 15 to 150 Pa s.

[0063] In the case of an oral composition in a liquid dosage form, the viscosity at 25°C measured with a BH viscometer should be 30 mPa·s or less, and preferably 0.7 to 30 mPa·s. [Example]

[0064] The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to these examples.

[0065] [Materials used in the Examples and Comparative Examples] -Component (A) Fluorine-containing compound- Sodium fluoride (Sodium fluoride, manufactured by Stella Chemifa Co., Ltd.) Sodium Monofluorophosphate (ICL Japan Co., Ltd.)

[0066] -Component (B) at least one of hinokitiol and thymol- Hinokitiol (Hinokitiol, manufactured by Takasago Chemical Co., Ltd.) Thymol (Thymol, manufactured by Kanto Chemical Co., Ltd.)

[0067] -Component (C) Nonionic surfactant- Sucrose fatty acid ester (sucrose laurate, Ryoto (registered trademark) Sugar Ester L-1695, manufactured by Mitsubishi Chemical Corporation, monoester content 80(%)) Sorbitan monostearate (NIKKOL (registered trademark) SS-10MV, manufactured by Nippon Surfactant Industries Co., Ltd.) Polysorbate 60 (polyoxyethylene sorbitan monostearate (20E.O.), NIKKOL (registered trademark) TS-10MV, manufactured by Nippon Surfactant Industries Co., Ltd.) Polyoxyethylene hydrogenated castor oil (20E.O.) (NIKKOL® HCO-20, manufactured by Nippon Surfactant Industries Co., Ltd.) Polyoxyethylene alkyl ether (Polyoxyethylene stearyl ether (20E.O.), NIKKOL (registered trademark) BS-20, manufactured by Nippon Surfactant Industry Co., Ltd.) Glycerin fatty acid ester (decaglyceryl laurate, SY Glystar (registered trademark) ML-750, manufactured by Sakamoto Pharmaceutical Co., Ltd.)

[0068] -Other ingredients- Carboxyvinyl polymer (Carbopol®, manufactured by Lubrizol) Sodium alginate (KIMICA ALGINE, manufactured by KIMICA Co., Ltd.) Sodium hydroxide (Kanto Chemical Co., Ltd.) Glycerin (Miyoshi Oil & Fat Co., Ltd., 85% cosmetic grade glycerin L) Fragrances A to P (The composition of each fragrance is shown in Table 5.) purified water

[0069] Using the above components as raw materials, compositions having the blending compositions shown in Tables 1 to 4 below were prepared.

[0070] The obtained compositions (Examples 1 to 21 and Comparative Examples 1 to 4) were evaluated according to the following procedures. The evaluation results are shown in Tables 1 to 4 below.

[0071] <Method for evaluating antibacterial activity> Forty microliters of frozen P. gingivalis culture was added to 4 mL of Todd-Hewitt Broth (Becton and Dickinson) culture medium (THBHM) containing 5 mg / L hemin (Sigma) and 1 mg / L vitamin K (Wako Pure Chemical Industries, Ltd.) and anaerobically incubated (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen) at 37°C for two nights to prepare a bacterial suspension. 49 mL of THBHM medium was added to 1 g of the prepared composition and stirred, after which further THBHM medium was added to prepare a dilution ratio of 400 to 2400. 50 μL of the bacterial suspension was added to 3 mL of each diluted medium, and after 10 days of anaerobically incubated at 37°C, bacterial growth was assessed by appearance, odor, and microscopy. The antibacterial activity is determined by conducting the same test four times and judging the average value of the highest dilution at which no bacterial growth was observed (no bacterial growth was observed by appearance, smell, or microscope).

[0072] Evaluation criteria ◎: Maximum dilution ratio of the agent is 1600 to 2400 times ○: The maximum dilution ratio of the agent is 800 to 1600 times ×: The maximum dilution ratio of the agent is less than 800 times

[0073] <Flavor evaluation> The evaluation was carried out by a sensory test using five expert panelists. The prepared compositions were placed in tube containers and stored at 50°C for one month, after which approximately 1 g of the composition was placed on a commercially available toothbrush and brushed for three minutes or applied to the oral cavity. The deterioration of the composition's flavor (deterioration of the balance of the composition's flavor) felt during use was evaluated according to the following criteria, using a similar prototype stored at -5°C for one month as a control.

[0074] Judgment criteria 5: The flavor has not deteriorated. 4: The flavor has hardly deteriorated. 3: The flavor has deteriorated slightly, but it can still be used without any problems. 2: The flavor has clearly deteriorated and there is an unpleasant feeling, but it is still usable. 1: The flavor has deteriorated significantly and the product cannot be used.

[0075] The average score of the five people who evaluated based on the above criteria was calculated and evaluated based on the following criteria. Evaluation criteria ◎: Average score is 4.0 or above ○: Average score is 3.0 or more and less than 4.0 points △: Average score is between 2.0 and 3.0 points ×: Average score is less than 2.0 points

[0076] <Method for evaluating the kneaded surface> The composition filled in a tube container was stored in a thermostatic chamber at 50°C for one month, and then returned to room temperature. The appearance of the composition when extruded from the tube container (paste surface) was evaluated according to the following criteria, using a composition stored at -5°C for one month as the control product in the same manner as above.

[0077] Evaluation criteria ◎: Equivalent to the target product, no wrinkles on the surface of the composition, no change in gloss ○: Compared to the control product, slight wrinkles and slight deterioration in surface gloss are observed on the surface of the composition, but there is no problem in terms of quality. ×: Compared to the control product, wrinkles were observed on the surface of the composition, the surface was lacking in luster, and there was a problem with the quality

[0078] [Table 1]

[0079] [Table 2]

[0080] [Table 3]

[0081] [Table 4]

[0082] [Table 5]

[0083] [Table 6]

[0084] [Table 7]

[0085] [Table 8]

[0086] The compositions of Comparative Examples 1 and 2, in which the content of component (A) as a fluorine-containing compound ion concentration did not satisfy the range of 15,000 to 950,000 ppm, and the composition of Comparative Example 3, which did not contain component (B), showed poor results in any of the categories of antibacterial activity, flavor, and smooth skin, whereas the compositions of Examples 1 to 20, which contained component (A) and component (B) and in which the content of component (A) satisfied the above numerical range, showed good results in all evaluation categories. Furthermore, when the fragrance A used in the compositions of Examples 1 to 20 and Comparative Examples 1 to 3 was replaced with fragrances B to P, the evaluation results did not change.

[0087] Furthermore, the compositions of Examples 1 to 20 showed good results in an antibacterial activity evaluation using Porphyromonas gingivalis, a typical bacterium that causes periodontal disease, demonstrating that the oral compositions of the present invention are also useful in the treatment or prevention of periodontal diseases, including pyorrhea.

[0088] Representative formulation examples of the present invention are shown below. Formulation example 1 (unit: mass%) (A) Sodium fluoride 1 (B) Hinokitiol 0.1 Dipotassium glycyrrhizinate 0.4 Cetylpyridinium chloride hydrate 0.05 Allantoin 0.3 (C) Sorbitan monostearate 0.2 (C) Polysorbate 60 0.2 (C) Sucrose fatty acid ester 0.5 Carboxyvinyl polymer 2 Hypromellose 0.3 Povidone 1 Sodium alginate 0.3 Glycerin 25 Ethanol 3 Light liquid paraffin 0.5 Sodium hydroxide 0.5 Fragrance composition A 1 Purified water balance Total 100

[0089] Formulation example 2 (unit: mass%) (A) Sodium fluoride 1 (B) Hinokitiol 0.1 Dipotassium glycyrrhizinate 0.4 Cetylpyridinium chloride hydrate 0.05 Allantoin 0.3 (C) Sorbitan monostearate 1 (C) Polysorbate 60 1.5 (C) Sucrose fatty acid ester 2 Sodium lauryl sulfate 1.6 Hydroxyethyl cellulose 1.5 Hypromellose 1 Thickening Silica 3 70% sorbitol solution 20 Propylene Glycol 5 PEG4000 0.4 Methylparaben 0.18 Sodium citrate 0.5 Titanium dioxide 0.4 Sodium hydroxide 0.2 Fragrance composition A 1 Purified water balance Total 100

[0090] Formulation example 3 (unit: mass%) (A) Sodium fluoride 1 (B) Hinokitiol 0.1 Dipotassium glycyrrhizinate 0.4 Cetylpyridinium chloride hydrate 0.05 Allantoin 0.3 (C) Glycerin fatty acid ester 0.2 (C) Polyoxyethylene hydrogenated castor oil (20) 1 (C) Polyoxyethylene (5) Stearyl Ether 1 Sodium lauroyl methyl taurate 0.6 Xanthan gum 1.5 Sodium polyacrylate 0.5 Sodium alginate 0.3 Thickening Silica 3 Abrasive Silica 15 Glycerin 30 Propylene Glycol 5 PEG400 0.4 Sodium benzoate 0.5 Benzalkonium chloride 0.02 Titanium dioxide 0.3 Sodium saccharin 0.07 Fragrance composition A 1 Purified water balance Total 100

[0091] Formulation example 4 (unit: mass%) (A) Sodium fluoride 1 (B) Hinokitiol 0.1 Glycyrrhetinic acid 0.3 Cetylpyridinium chloride hydrate 0.05 Panthenol 0.3 Tocopheryl Acetate 2 (C) Sorbitan monostearate 0.2 (C) Polysorbate 60 0.2 (C) Sucrose fatty acid ester 0.5 Hydroxyethyl cellulose 1.5 Hypromellose 1 Thickening Silica 3 Glycerin 30 Propylene Glycol 5 PEG400 0.4 Sodium benzoate 0.5 Benzalkonium chloride 0.02 Titanium dioxide 0.3 Sodium saccharin 0.07 Fragrance composition A 1 Purified water balance Total 100

[0092] Formulation example 5 (unit: mass%) (A) Sodium fluoride 1 (B) Hinokitiol 0.1 Glycyrrhetinic acid 0.3 Cetylpyridinium chloride hydrate 0.05 Panthenol 0.3 Tocopheryl Acetate 2 (C) Sorbitan monostearate 1 (C) Polysorbate 60 1.5 (C) Sucrose fatty acid ester 2 Sodium lauryl sulfate 1.6 Xanthan gum 1.5 Sodium polyacrylate 0.5 Sodium alginate 0.3 Thickening Silica 3 Abrasive Silica 15 Glycerin 25 Ethanol 3 Light liquid paraffin 0.5 Sodium hydroxide 0.5 Fragrance composition A 1 Purified water balance Total 100

[0093] Formulation example 6 (unit: mass%) (A) Sodium fluoride 1 (B) Hinokitiol 0.1 Glycyrrhetinic acid 0.3 Cetylpyridinium chloride hydrate 0.05 Panthenol 0.3 Tocopheryl Acetate 2 (C) Glycerin fatty acid ester 0.2 (C) Polyoxyethylene hydrogenated castor oil (20) 1 (C) Polyoxyethylene (5) Stearyl Ether 1 Sodium lauroyl methyl taurate 0.6 Carboxyvinyl polymer 2 Hypromellose 0.3 Povidone 1 Sodium alginate 0.3 70% sorbitol solution 20 Propylene Glycol 5 PEG4000 0.4 Methylparaben 0.18 Sodium citrate 0.5 Titanium dioxide 0.4 Sodium hydroxide 0.2 Fragrance composition A 1 Purified water balance Total 100

[0094] Formulation example 7 (unit: mass%) (A) Sodium fluoride 1 (B) Hinokitiol 0.1 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Tocopheryl acetate 0.1 Dipotassium glycyrrhizinate 0.05 Sodium chloride 5 (C) Sorbitan monostearate 0.2 (C) Polysorbate 60 0.2 (C) Sucrose fatty acid ester 0.5 Sodium lauryl sulfate 1.6 Carboxyvinyl polymer 2 Hypromellose 0.3 Povidone 1 Sodium alginate 0.3 Thickening Silica 3 Abrasive Silica 15 70% sorbitol solution 20 Propylene Glycol 5 PEG4000 0.4 Sodium benzoate 0.5 Benzalkonium chloride 0.02 Titanium dioxide 0.3 Sodium saccharin 0.07 Fragrance composition A 1 Purified water balance Total 100

[0095] Formulation example 8 (unit: mass%) (A) Sodium fluoride 1 (B) Hinokitiol 0.1 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Tocopheryl acetate 0.1 Dipotassium glycyrrhizinate 0.05 Sodium chloride 5 (C) Sorbitan monostearate 1 (C) Polysorbate 60 1.5 (C) Sucrose fatty acid ester 2 Sodium lauroyl methyl taurate 0.6 Hydroxyethyl cellulose 1.5 Hypromellose 1 Glycerin 30 Propylene Glycol 5 PEG400 0.4 Ethanol 3 Light liquid paraffin 0.5 Sodium hydroxide 0.5 Fragrance composition A 1 Purified water balance Total 100

[0096] Formulation example 9 (unit: mass%) (A) Sodium fluoride 1 (B) Hinokitiol 0.1 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Allantoin 0.3 Dipotassium glycyrrhizinate 0.05 Sodium chloride 5 (C) Glycerin fatty acid ester 0.2 (C) Polyoxyethylene hydrogenated castor oil (20) 1 (C) Polyoxyethylene (5) Stearyl Ether 1 Xanthan gum 1.5 Sodium polyacrylate 0.5 Sodium alginate 0.3 Thickening Silica 3 Glycerin 25 Methylparaben 0.18 Sodium citrate 0.5 Titanium dioxide 0.4 Sodium hydroxide 0.2 Fragrance composition A 1 Purified water balance Total 100

[0097] Formulation example 10 (unit: mass%) (A) Sodium monofluorophosphate 3.8 (B) Hinokitiol 0.1 Dipotassium glycyrrhizinate 0.4 Cetylpyridinium chloride hydrate 0.05 Allantoin 0.3 (C) Sorbitan monostearate 0.2 (C) Polysorbate 60 0.2 (C) Sucrose fatty acid ester 0.5 Sodium lauroyl methyl taurate 0.6 Xanthan gum 1.5 Sodium polyacrylate 0.5 Sodium alginate 0.3 Thickening Silica 3 70% sorbitol solution 20 Propylene Glycol 5 PEG4000 0.4 Ethanol 3 Light liquid paraffin 0.5 Sodium hydroxide 0.5 Fragrance composition A 1 Purified water balance Total 100

[0098] Formulation example 11 (unit: mass%) (A) Sodium monofluorophosphate 3.8 (B) Hinokitiol 0.1 Dipotassium glycyrrhizinate 0.4 Cetylpyridinium chloride hydrate 0.05 Allantoin 0.3 (C) Sorbitan monostearate 1 (C) Polysorbate 60 1.5 (C) Sucrose fatty acid ester 2 Carboxyvinyl polymer 2 Hypromellose 0.3 Povidone 1 Sodium alginate 0.3 Thickening Silica 3 Abrasive Silica 15 Glycerin 30 Propylene Glycol 5 PEG400 0.4 Methylparaben 0.18 Sodium citrate 0.5 Titanium dioxide 0.4 Sodium hydroxide 0.2 Fragrance composition A 1 Purified water balance Total 100

[0099] Formulation example 12 (unit: mass%) (A) Sodium monofluorophosphate 3.8 (B) Hinokitiol 0.1 Dipotassium glycyrrhizinate 0.4 Cetylpyridinium chloride hydrate 0.05 Allantoin 0.3 (C) Glycerin fatty acid ester 0.2 (C) Polyoxyethylene hydrogenated castor oil (20) 1 (C) Polyoxyethylene (5) Stearyl Ether 1 Sodium lauryl sulfate 1.6 Hydroxyethyl cellulose 1.5 Hypromellose 1 Glycerin 25 Sodium benzoate 0.5 Benzalkonium chloride 0.02 Titanium dioxide 0.3 Sodium saccharin 0.07 Fragrance composition A 1 Purified water balance Total 100

[0100] Formulation example 13 (unit: mass%) (A) Sodium monofluorophosphate 3.8 (B) Hinokitiol 0.1 Glycyrrhetinic acid 0.3 Cetylpyridinium chloride hydrate 0.05 Panthenol 0.3 Tocopheryl Acetate 2 (C) Sorbitan monostearate 0.2 (C) Polysorbate 60 0.2 (C) Sucrose fatty acid ester 0.5 Sodium lauryl sulfate 1.6 Xanthan gum 1.5 Sodium polyacrylate 0.5 Sodium alginate 0.3 Glycerin 30 Propylene Glycol 5 PEG400 0.4 Methylparaben 0.18 Sodium citrate 0.5 Titanium dioxide 0.4 Sodium hydroxide 0.2 Fragrance composition A 1 Purified water balance Total 100

[0101] Formulation example 14 (unit: mass%) (A) Sodium monofluorophosphate 3.8 (B) Hinokitiol 0.1 Glycyrrhetinic acid 0.3 Cetylpyridinium chloride hydrate 0.05 Panthenol 0.3 Tocopheryl Acetate 2 (C) Sorbitan monostearate 1 (C) Polysorbate 60 1.5 (C) Sucrose fatty acid ester 2 Sodium lauroyl methyl taurate 0.6 Carboxyvinyl polymer 2 Hypromellose 0.3 Povidone 1 Sodium alginate 0.3 Thickening Silica 3 Glycerin 25 Sodium benzoate 0.5 Benzalkonium chloride 0.02 Titanium dioxide 0.3 Sodium saccharin 0.07 Fragrance composition A 1 Purified water balance Total 100

[0102] Formulation example 15 (unit: mass%) (A) Sodium monofluorophosphate 3.8 (B) Hinokitiol 0.1 Glycyrrhetinic acid 0.3 Cetylpyridinium chloride hydrate 0.05 Panthenol 0.3 Tocopheryl Acetate 2 (C) Glycerin fatty acid ester 0.2 (C) Polyoxyethylene hydrogenated castor oil (20) 1 (C) Polyoxyethylene (5) Stearyl Ether 1 Hydroxyethyl cellulose 1.5 Hypromellose 1 Thickening Silica 3 Abrasive Silica 15 70% sorbitol solution 20 Propylene Glycol 5 PEG4000 0.4 Ethanol 3 Light liquid paraffin 0.5 Sodium hydroxide 0.5 Fragrance composition A 1 Purified water balance Total 100

[0103] Formulation example 16 (unit: mass%) (A) Sodium monofluorophosphate 3.8 (B) Hinokitiol 0.1 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Tocopheryl acetate 0.1 Dipotassium glycyrrhizinate 0.05 Sodium chloride 5 (C) Sorbitan monostearate 0.2 (C) Polysorbate 60 0.2 (C) Sucrose fatty acid ester 0.5 Sodium lauroyl methyl taurate 0.6 Hydroxyethyl cellulose 1.5 Hypromellose 1 Thickening Silica 3 Abrasive Silica 15 Glycerin 25 Methylparaben 0.18 Sodium citrate 0.5 Titanium dioxide 0.4 Sodium hydroxide 0.2 Fragrance composition A 1 Purified water balance Total 100

[0104] Formulation example 17 (unit: mass%) (A) Sodium monofluorophosphate 3.8 (B) Hinokitiol 0.1 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Tocopheryl acetate 0.1 Dipotassium glycyrrhizinate 0.05 Sodium chloride 5 (C) Sorbitan monostearate 1 (C) Polysorbate 60 1.5 (C) Sucrose fatty acid ester 2 Xanthan gum 1.5 Sodium polyacrylate 0.5 Sodium alginate 0.3 70% sorbitol solution 20 Propylene Glycol 5 PEG4000 0.4 Sodium benzoate 0.5 Benzalkonium chloride 0.02 Titanium dioxide 0.3 Sodium saccharin 0.07 Fragrance composition A 1 Purified water balance Total 100

[0105] Formulation example 18 (unit: mass%) (A) Sodium monofluorophosphate 3.8 (B) Hinokitiol 0.1 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Tocopheryl acetate 0.1 Dipotassium glycyrrhizinate 0.05 Sodium chloride 5 (C) Glycerin fatty acid ester 0.2 (C) Polyoxyethylene hydrogenated castor oil (20) 1 (C) Polyoxyethylene (5) Stearyl Ether 1 Sodium lauryl sulfate 1.6 Carboxyvinyl polymer 2 Hypromellose 0.3 Povidone 1 Sodium alginate 0.3 Thickening Silica 3 Glycerin 30 Propylene Glycol 5 PEG400 0.4 Ethanol 3 Light liquid paraffin 0.5 Sodium hydroxide 0.5 Fragrance composition A 1 Purified water balance Total 100

Claims

1. Component (A): a fluorine-containing compound, and Component (B): at least one of hinokitiol and thymol Contains The content of component (A) is an amount equivalent to a fluorine ion concentration of 3,000 to 20,000 ppm. Oral composition.

2. 2. The oral composition according to claim 1, wherein component (A) is at least one selected from the group consisting of sodium fluoride, sodium monofluorophosphate, and stannous fluoride.

3. 3. The oral composition according to claim 1, further comprising component (C): a nonionic surfactant.

4. 3. The oral composition according to claim 1, wherein the content of component (A) is in an amount equivalent to a fluoride ion concentration of 4,000 to 15,000 ppm.

5. The oral composition of claim 3, wherein component (C) is one or more selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid esters, sucrose fatty acid esters, maltose fatty acid esters, sugar alcohol fatty acid esters, alkylolamides, polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene glycol fatty acid esters, polyethylene glycol fatty acid esters, polyoxyethylene polyoxypropylene glycol, fatty acid diethanolamides, polyoxyethylene alkyl ethers, and polyoxyethylene alkyl phenyl ethers.

6. 3. The oral composition according to claim 1, wherein the ratio (A) / (B) of the fluoride ion concentration corresponding to the content of component (A) to the content of component (B) is 15,000 to 950,000.

7. 3. The oral composition according to claim 1, which is a dentifrice composition.

8. 3. The oral composition according to claim 1, which is an external application composition.

9. 3. The oral composition according to claim 1, which is for treating or preventing periodontal disease.

10. Component (A): a fluorine-containing compound, and Component (B): at least one of hinokitiol and thymol Contains A therapeutic or preventive agent for periodontal disease, wherein the content of component (A) is an amount equivalent to 3,000 to 20,000 ppm in terms of fluoride ion concentration.