Instant sterilization composition

Abstract

To provide a sterilizing composition with improved instantaneous sterilization effect. [Solution] The bactericidal composition is formulated with (A) an anionic surfactant, (B) a phenolic bactericide, and (C) components of essential oils.

Description

Technical Field

[0001] The present invention relates to a composition having a high bactericidal effect in a short period of time, that is, an instant bactericidal composition.

Background Art

[0002] [[ID=Il]] There are various bacteria in the oral cavity, and it has conventionally been known that these can cause dental caries, periodontal disease, etc. In order to suppress the occurrence of such dental caries and periodontal disease, it is known that it is effective to remove (sterilize) bacteria present in the oral cavity by brushing teeth or rinsing with an oral composition such as a dentifrice or mouthwash having a bactericidal effect.

[0003] For example, anionic surfactants such as sodium lauroyl sarcosinate are known as components that exhibit a bactericidal effect against bacteria in the oral cavity, and techniques using such anionic surfactants as components of oral compositions have been reported (for example, Patent Document 1). In addition, phenolic bactericides such as thymol, essential oils such as menthol and / or their constituent components are known to have an antibacterial effect, and techniques using such phenolic bactericides, essential oils and their constituent components as components of oral compositions have been reported (for example, Patent Documents 2 and 3).

[0004] However, although the brushing time is generally about 3 minutes and is carried out over a certain period of time, there is a problem that the bactericidal effect may not be sufficiently exhibited by conventional oral compositions because there are individual differences in the length of time the dentifrice is held in the oral cavity and the application form. In addition, since rinsing with mouthwash is generally carried out in a short time of about 20 seconds, there is a problem that the bactericidal effect may not be sufficiently exhibited in such a short time.

[0005] To solve these problems, efforts are being made to develop bactericidal compositions that can kill bacteria in a short time (i.e., have an instantaneous bactericidal effect). For example, techniques that exhibit such an instantaneous bactericidal effect have been reported using combinations of thymol with certain nicotinic acid derivatives, and combinations of isopropylmethylphenol with certain sugars or sugar alcohols (see, for example, Patent Documents 4 and 5). [Prior art documents] [Patent Documents]

[0006] [Patent Document 1] Japanese Patent Publication No. 2022-097295 [Patent Document 2] Japanese Patent Publication No. 2018-095574 [Patent Document 3] Japanese Patent Publication No. 2004-018470 [Patent Document 4] Japanese Patent Publication No. 2021-155364 [Patent Document 5] Japanese Patent Publication No. 2021-104978

[0007] However, the reality is that conventional technologies do not provide sufficient instantaneous sterilization. [Overview of the project] [Problems that the invention aims to solve]

[0008] Under these circumstances, providing a sterilizing composition with improved instantaneous sterilization effect compared to conventional technologies remains an ongoing technical challenge.

[0009] Therefore, an object of the present invention is to provide a sterilizing composition that has an improved instantaneous sterilizing effect compared to the prior art, i.e., an instantaneous sterilizing composition. Another object of the present invention is to provide a method for instantly and sufficiently sterilizing bacteria compared to the prior art. [Means for solving the problem]

[0010] As a result of diligent research, the inventors have found that the above-mentioned problems can be solved by combining (A) anionic surfactant, (B) phenolic disinfectant, and (C) essential oil components in a disinfectant composition. The present invention is based on this finding.

[0011] In other words, the present invention provides the following invention. [1] (A) Anionic surfactant, (B) Phenolic fungicides, and (C) Components of essential oils A composition for instantaneous sterilization containing the following: [2] The instantaneous sterilization composition according to [1], which contains an essential oil. [3] The instantaneous sterilization composition according to [1] or [2], wherein the (A) anionic surfactant contains at least one selected from the group consisting of sodium lauroyl sarcosinate, sodium lauryl sulfate, sodium lauroyl methyl taurate, and sodium tetradecenesulfonate. [4] The instantaneous sterilization composition according to any one of [1] to [3], wherein the (B) phenolic fungicide contains at least one selected from the group consisting of thymol, isopropylmethylphenol, and hinokitiol. [5](C) The instantaneous sterilization composition according to any one of [1] to [4], wherein the essential oil component contains at least one selected from the group consisting of menthol, terpinene, citral, menthoxypropanediol, carvacrol, terpineol, limonene, geraniol, eugenol, and camphor. [6] The instantaneous sterilization composition according to any one of [1] to [5], wherein the content of the anionic surfactant (A) is 0.001 to 5% by mass with respect to the total mass of the instantaneous sterilization composition. [7] The instantaneous sterilization composition according to any one of [1] to [6], wherein the content of (B) phenolic bactericide is 0.0005 to 10% by mass with respect to the total mass of the instantaneous sterilization composition. [8](C) The instantaneous sterilization composition according to any one of [1] to [7], wherein the content of the constituent components of the essential oil is 0.0005 to 10% by mass relative to the total mass of the instantaneous sterilization composition. [9] A composition for instantaneous sterilization according to any one of [1] to [8], used for sterilization in the oral cavity. [Effects of the Invention]

[0012] According to the present invention, it is possible to improve the instantaneous sterilization effect of a sterilizing composition compared to the conventional technology. [Modes for carrying out the invention]

[0013] In this specification, "instantaneous bactericidal effect" with respect to a bactericidal composition refers to the bactericidal effect achieved within a short period after application of the bactericidal composition, for example, a bactericidal effect achieved within 20 seconds after application of the bactericidal composition. Furthermore, in this specification, "instantaneous bactericidal composition" refers to a bactericidal composition having the instantaneous bactericidal effect described above. Therefore, the instantaneous bactericidal composition of the present invention is a bactericidal composition in which the bactericidal effect achieved within a short period after application is improved compared to the prior art.

[0014] [Instant sterilization composition] According to one aspect of the present invention, a bactericidal composition (hereinafter also simply referred to as "instant bactericidal composition" or "the instant bactericidal composition of the present invention") is provided that has an improved instantaneous bactericidal effect compared to the prior art. The instant bactericidal composition of the present invention contains component (A) an anionic surfactant, component (B) a phenolic bactericide, and component (C) a component of essential oils. By containing a combination of the three components (A) to (C), the instant bactericidal composition of the present invention exhibits an improved instantaneous bactericidal effect compared to bactericidal compositions containing one of these components alone or a combination of any two of these components. Components (A) to (C) will be described in detail below.

[0015] Ingredient (A) The instant sterilizing composition of the present invention contains, as an essential component, component (A) an anionic surfactant. By containing an anionic surfactant in the instant sterilizing composition, a sterilizing effect can be achieved in the oral cavity, on the skin surface, and in daily necessities. The anionic surfactant may be used alone or in combination of two or more kinds.

[0016] The anionic surfactant is not particularly limited as long as the effects of the present invention are achieved, and those that can be used as components of the sterilizing composition can be appropriately selected and used. Examples of such anionic surfactants include lauryl sulfate, lauroyl sarcosinate, lauroyl methyl taurine salt, alkyl glutamate, tetradecene sulfonate, etc. Here, examples of the salt include sodium salt, potassium salt, calcium salt, magnesium salt, etc.

[0017] In a preferred embodiment, the anionic surfactant contains one or more selected from the group consisting of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium lauroyl methyl taurine, and sodium tetradecene sulfonate.

[0018] The content of the anionic surfactant in the instant sterilizing composition of the present invention is not particularly limited as long as the effects of the present invention are achieved, but is preferably 0.001 to 5% by mass, more preferably 0.01 to 1% by mass, and even more preferably 0.05 to 0.3% by mass based on the total mass of the instant sterilizing composition. By setting the content of the anionic surfactant in the instant sterilizing composition to 0.001% by mass or more, sufficient sterilizing ability can be imparted to the instant sterilizing composition. On the other hand, by setting the content of the anionic surfactant in the instant sterilizing composition to 5% by mass or less, the feel of use of the instant sterilizing composition and the stability of the preparation can be made good.

[0019] Ingredient (B) The instantaneous sterilization composition of the present invention contains component (B) a phenolic disinfectant as an essential component. By containing a phenolic disinfectant in the instantaneous sterilization composition, the instantaneous sterilization effect can be improved. The phenolic disinfectant may be used alone or in combination of two or more types.

[0020] The phenolic fungicide is not particularly limited as long as it achieves the effects of the present invention, and any phenolic fungicide that can be used as a component of the fungicide composition can be appropriately selected and used. Examples of such phenolic fungicides include phenol, cresol, triclosan, thymol, isopropylmethylphenol, hinokitiol, and bisphenol.

[0021] In a preferred embodiment, the phenolic fungicide contains at least one selected from the group consisting of thymol, isopropylmethylphenol, and hinokitiol.

[0022] The content of the phenolic disinfectant in the instantaneous sterilization composition of the present invention is not particularly limited as long as the effects of the present invention are achieved, but is preferably 0.0005 to 10% by mass, more preferably 0.005 to 5% by mass, and even more preferably 0.01 to 1% by mass, based on the total mass of the instantaneous sterilization composition. By setting the content of the phenolic disinfectant in the instantaneous sterilization composition to 0.0005% by mass or more, the instantaneous sterilization effect of the instantaneous sterilization composition can be sufficiently improved. On the other hand, by setting the content of the phenolic disinfectant in the instantaneous sterilization composition to 10% by mass or less, the instantaneous sterilization composition can be formulated stably, and the feel of the instantaneous sterilization composition can be made even better.

[0023] The content of the phenolic disinfectant in the instantaneous sterilization composition of the present invention is adjusted so that, when the content of component (A) anionic surfactant is 1 part by mass, the content of the phenolic disinfectant is preferably 1 / 10000 to 1000 parts by mass, more preferably 1 / 200 to 500 parts by mass, and even more preferably 1 / 30 to 20 parts by mass. By setting the content of the phenolic disinfectant relative to the anionic surfactant in the instantaneous sterilization composition to 1 / 10000 to 1000 parts by mass, the instantaneous sterilization effect of the instantaneous sterilization composition can be further improved.

[0024] Ingredients (C) The instantaneous sterilization composition of the present invention contains component (C) essential oil components as an essential component. By containing essential oil components in the instantaneous sterilization composition, the instantaneous sterilization effect of the composition can be improved. One essential oil component may be used alone, or two or more components may be used in combination.

[0025] Essential oils are volatile oils extracted from plants, and component (C) can be selected and used from among the components that make up such essential oils. Examples of components that make up essential oils include terpenes, benzenes, alcohols, aldehydes, ketones, phenols, esters, carboxylic acids, oxides, lactones, and their derivatives. Specifically, the components that make up essential oils contain at least one selected from the group consisting of terpenoid essential oil components such as menthol, terpinene, citral, menthoxypropanediol, carvacrol, terpineol, limonene, geraniol, camphor, menthone, α-pinene, and cineole, and phenylpropanoid essential oil components such as eugenol, anethole, cinnamaldehyde, and cinnamaldehyde.

[0026] In a preferred embodiment, the essential oil comprises at least one selected from the group consisting of menthol, terpinene, citral, menthoxypropanediol, carvacrol, terpineol, limonene, geraniol, eugenol, and camphor.

[0027] The content of essential oil components in the instantaneous sterilization composition of the present invention is not particularly limited as long as the effects of the present invention are achieved, but is preferably 0.0005 to 10% by mass, more preferably 0.005 to 5% by mass, and even more preferably 0.01 to 1% by mass, relative to the total mass of the instantaneous sterilization composition. By setting the content of essential oil components in the instantaneous sterilization composition to 0.0005% by mass or more, the instantaneous sterilization effect of the instantaneous sterilization composition can be sufficiently improved. On the other hand, by setting the content of essential oil components in the instantaneous sterilization composition to 10% by mass or less, the instantaneous sterilization composition can be formulated stably, and the feel of the instantaneous sterilization composition can be made even better.

[0028] The content of essential oil components in the instantaneous sterilization composition of the present invention is adjusted so that, when the content of component (A) anionic surfactant is 1 part by mass, the content of essential oil components is preferably 1 / 10000 to 1000 parts by mass, more preferably 1 / 200 to 500 parts by mass, and even more preferably 1 / 30 to 20 parts by mass. By setting the content of essential oil components relative to the anionic surfactant in the instantaneous sterilization composition to 1 / 10000 to 1000 parts by mass, the instantaneous sterilization effect of the instantaneous sterilization composition can be further improved.

[0029] The content of essential oil components in the instantaneous sterilization composition of the present invention is adjusted so that, when the content of component (B) phenolic disinfectant described above is 1 part by mass, the content of essential oil components is preferably 1 / 20000 to 20000 parts by mass, more preferably 1 / 1000 to 1000 parts by mass, and even more preferably 1 / 100 to 100 parts by mass. By setting the content of essential oil components relative to the phenolic disinfectant in the instantaneous sterilization composition to 1 / 20000 to 20000 parts by mass, the instantaneous sterilization effect of the instantaneous sterilization composition can be further improved.

[0030] In the instantaneous sterilization composition of the present invention, the components constituting the essential oil may be contained as a single compound or as a mixture of two or more compounds. For example, the instantaneous sterilization composition of the present invention may contain an essential oil containing one or more components constituting the essential oil.

[0031] Examples of essential oils include peppermint oil, eucalyptus oil, orange oil, turpentine oil, peppermint oil, spearmint oil, camphor oil, citron oil, perilla oil, tea tree oil, lemon oil, sage oil, rosemary oil, turpentine oil, clove oil, fennel oil, and cinnamon oil. Essential oils may be used individually or in combination of two or more.

[0032] Other ingredients The instantaneous sterilization composition of the present invention may, in addition to the components (A) to (C) described above, optionally contain other components, such as abrasives, wetting agents, solvents, binders, fragrances, excipients, sweeteners, pH adjusters, preservatives, emulsifiers, solubilizers, foaming agents, lubricants, oils, surfactants, chelating agents, dyes, pigments, antioxidants, flavoring agents, and other agents. These other components are commonly used in pharmaceutical compositions, oral compositions, or food formulations and can be appropriately selected within a range that does not impair the effects of the present invention, and can be incorporated into the instantaneous sterilization composition in appropriate amounts. The other components may be used individually or in combination of two or more.

[0033] Examples of abrasives include calcium carbonate, calcium phosphate, discalcium phosphate, calcium pyrophosphate, insoluble calcium metaphosphate, hydrated silicic acid, anhydrous silicic acid, titanium dioxide, amorphous silica, crystalline silica, aluminosilicate, aluminum oxide, aluminum hydroxide, and resin. Abrasives may be used individually or in combination of two or more. The abrasive content is, for example, 3 to 60% by mass of the total mass of the instantaneous sterilization composition of the present invention.

[0034] Examples of humectants include polyhydric alcohols such as glycerin, sorbitol, polyethylene glycol, propylene glycol, ethylene glycol, 1,3-butylene glycol, polypropylene glycol, xylitol, maltitol, and lactitol. A single humectant may be used, or two or more may be used in combination. The content of the humectant is, for example, 0.1 to 50% by mass of the total mass of the instantaneous sterilization composition of the present invention.

[0035] Examples of solvents include water and organic solvents (e.g., alcohols such as ethanol, propyl alcohol, and isopropyl alcohol), with water being particularly preferred. The solvent may be used alone or in combination of two or more types. These alcohols can be blended individually or in combination of two or more types. The solvent content is, for example, 99% by mass or less based on the total mass of the instantaneous sterilization composition of the present invention.

[0036] Examples of binders include cellulose derivatives such as carrageenan, carboxymethylcellulose, sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, and hydroxypropylmethylcellulose; alkali metal alginates such as sodium alginate; gums such as xanthan gum, tragacanth gum, and gum arabic; synthetic binders such as polyvinyl alcohol and sodium polyacrylate; and inorganic binders such as silica gel, aluminum silica gel, and bee gum. A single binder may be used, or two or more may be used in combination. The binder content is, for example, 0.5 to 10% by mass of the total mass of the instantaneous sterilization composition of the present invention.

[0037] Examples of fragrances include known fragrance materials, such as blended fragrances of strawberry, apple, banana, pineapple, grape, mango, butter, milk, fruit mix, and tropical fruit flavors. One fragrance may be used alone, or two or more may be used in combination. The fragrance content is, for example, 0.0001 to 1.0% by mass of the total mass of the instantaneous sterilization composition of the present invention.

[0038] Examples of excipients include sucrose, lactose, starch, glucose, crystalline cellulose, mannitol, sorbitol, xylitol, erythritol, palatinitol, palatinose, maltitol, trehalose, lactitol, lactulose, reduced starch sugar, reduced isomaltoligosaccharide, coupling sugar, gum base, gum arabic, gelatin, cetyl methylcellulose, light anhydrous silicic acid, magnesium aluminate, calcium aluminometasilicate, sodium bicarbonate, calcium phosphate, etc. Excipients may be used individually or in combination of two or more. The excipient content is, for example, 0.01 to 30% by mass of the total mass of the instantaneous sterilization composition of the present invention.

[0039] Examples of sweeteners include palatinite, aspartame, sodium saccharin, acesulfame potassium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillalumin, thaumatin, aspartylphenylalanyl methyl ester, and ρ-methoxycinnamic aldehyde. A single sweetener may be used, or two or more may be used in combination. The sweetener content is, for example, 0.01 to 1% by mass relative to the total mass of the instantaneous sterilization composition of the present invention.

[0040] Examples of pH adjusting agents include citric acid, phosphoric acid, pantothenic acid, malic acid, pyrophosphate, lactic acid, tartaric acid, glycerophosphate, acetic acid, nitric acid, and chemically possible salts thereof such as disodium hydrogen phosphate, as well as sodium hydroxide. One pH adjusting agent may be used alone, or two or more may be used in combination. The content of the pH adjusting agent is, for example, 0.01 to 2% by mass of the total mass of the instantaneous sterilization composition of the present invention.

[0041] Examples of preservatives include para-hydroxybenzoic acid esters, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, phenoxyethanol, and alkyldiaminoethylglycine hydrochloride. A single preservative may be used, or two or more may be used in combination. The preservative content is, for example, 0.005 to 5% by mass of the total mass of the instantaneous sterilization composition of the present invention.

[0042] Examples of emulsifiers include polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, sodium stearoyl lactylate, soybean phospholipids, and alkyltrimethylammonium chloride. One emulsifier may be used alone, or two or more may be used in combination. The emulsifier content is, for example, 0.05 to 30% by mass of the total mass of the instantaneous sterilization composition of the present invention.

[0043] Examples of solubilizing agents include esters, polyethylene glycol derivatives, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, and sulfated fatty alcohols. One solubilizing agent may be used alone, or two or more may be used in combination. The content of the solubilizing agent is, for example, 0.05 to 30% by mass of the total mass of the instantaneous sterilization composition of the present invention.

[0044] Examples of foaming agents include sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium alkyl sulfosuccinate, sodium coconut oil fatty acid monoglycerin sulfonate, sodium α-olefin sulfonate, N-acyl amino acid salts such as N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, maltitol fatty acid esters, sucrose fatty acid esters, polyglycerin fatty acid esters, fatty acid diethanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, and polyoxyethylene fatty acid esters. Foaming agents may be used individually or in combination of two or more.

[0045] Examples of lubricants include magnesium stearate, sucrose fatty acid esters, talc, and hydrogenated oils.

[0046] Examples of oils other than those used as essential oils as described above include coconut oil, olive oil, sesame oil, peanut oil, parsley oil, parsley seed oil, and safflower oil. Oils may be used individually or in combination of two or more.

[0047] As the surfactant, various surfactants other than the anionic surfactants mentioned above can be used. One type of surfactant may be used alone, or two or more types may be used in combination.

[0048] Examples of chelating agents include pyrophosphate or its salts, polyphosphate or its salts, metaphosphate or its salts, phytic acid or its salts, hydroxyethanediphosphonic acid or its salts, aminotrimethylenephosphonic acid or its salts, ethylenediaminetetramethylenephosphonic acid or its salts, phosphonobutanetricarboxylic acid or its salts, EDTA or its salts, nitrilotriacetic acid (NTA) or its salts, hydroxyethyliminodiacetic acid (HIDA) or its salts, tetrasodium 3-hydroxy-2,2'-iminodisuccinate (HIDS) or its salts, diethylenetriaminepentaacetic acid (DPTA) or its salts, hydroxyethyl Examples of chelating agents include ethylenediaminetriacetic acid (HEDTA) or its salts, dihydroxyethylglycine (DHEG) or its salts, L-glutamic acid diacetic acid (GLDA) or its salts, methylglycine diacetic acid (MGDA), aspartic acid or its salts, glutamic acid or its salts, citric acid or its salts, malic acid or its salts, tartaric acid or its salts, gluconic acid or its salts, lactic acid or its salts, mandelic acid or its salts, glycolic acid or its salts or its salts, oxalic acid or its salts, maleic acid or its salts, malonic acid or its salts, succinic acid or its salts, pantothenic acid or its salts, phthalic acid or its salts, fumaric acid or its salts, etc. The chelating agent may be used alone or in combination of two or more types. The content of the chelating agent is, for example, 0 to 30% by mass of the total mass of the instantaneous sterilization composition of the present invention.

[0049] In addition to the ingredients mentioned above, the product may also contain, for example, a dye such as Blue No. 1, pigments such as titanium dioxide, antioxidants such as dibutylhydroxytoluene, tea extract, tea distillate, and flavoring agents such as sodium glutamate.

[0050] The instantaneous sterilization composition of the present invention may further contain medicinal ingredients such as humectants, antibacterial agents, anti-inflammatory agents, fluoride, vitamins, and herbal extracts. These medicinal ingredients can be appropriately selected from those that can be used in pharmaceuticals, foods, cosmetics, and oral compositions.

[0051] Examples of moisturizers include amino acids and their salts, pyrrolidone carboxylic acid, mucin, hyaluronic acid and its salts, mucopolysaccharides such as chondroitin sulfate, sodium lactate, urea, panthenol, natural extracts such as aloe extract, rosemary extract, thyme extract, and tea extract (tea distillate extract), as well as so-called extracellular matrix components such as collagen and elastin. Moisturizers may be used individually or in combination of two or more.

[0052] Examples of antibacterial agents include cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, decalinium chloride, chlorhexidine hydrochloride, sodium chlorhexidine gluconate, bisabolol chlorhexidine, lactoferrin, parabens, and butylparabens. Antibacterial agents may be used individually or in combination of two or more.

[0053] Examples of anti-inflammatory agents include lysozyme chloride, ε-aminocaproic acid, aluminum hydroxyl allantoin, glycyrrhetinic acid, glycyrrhizinates, guaiazulene sulfonic acid, and dl-α-tocopherol acetate. Anti-inflammatory agents may be used individually or in combination of two or more.

[0054] Examples of fluorides include sodium fluoride, potassium fluoride, sodium monofluorophosphate, and stannous fluoride. Fluorides may be used individually or in combination of two or more.

[0055] Examples of vitamin supplements include vitamin A compounds such as retinoic acid and beta-carotene, pantothenic acid and its salts, vitamin B compounds such as niacin and biotin, vitamin C compounds such as ascorbic acid and its salts and derivatives, vitamin E compounds such as alpha-tocopherol, and folic acid. Vitamin supplements may be used individually or in combination of two or more types.

[0056] Examples of herbal extracts include chamomile extract, valerian extract, jujube extract, hop extract, ramender extract, linden extract, quince extract, honeysuckle extract, bamboo grass extract, elm extract, clove extract, ginseng extract, salvia extract, and soapberry extract. These herbal extracts may be used individually or in combination of two or more.

[0057] The content of the above-mentioned humectants, antibacterial agents, anti-inflammatory agents, fluorides, vitamins, herbal extracts, and other medicinal ingredients in the instantaneous sterilization composition of the present invention is not particularly limited as long as the effects of the present invention are achieved, and is, for example, 0.001 to 5.0% by mass, preferably 0.01 to 1.0% by mass.

[0058] The instantaneous sterilization composition of the present invention can be in various forms depending on its application. Examples of forms of the instantaneous sterilization composition of the present invention include liquid (e.g., emulsion, solubilized), gel, paste, tablet, effervescent tablet, powder, granules, etc.

[0059] The instantaneous sterilization composition of the present invention can be used as various compositions such as oral compositions, cosmetic compositions, detergent compositions, and skin compositions. Oral compositions are compositions intended for sterilizing the oral cavity of humans or non-human animals (e.g., oral mucosa such as the buccal mucosa, tongue, gums, teeth, etc.). Examples of oral compositions include toothpaste, liquid toothpaste, mouthwash, and oral humectants.

[0060] Examples of cosmetic compositions include lotions, facial cleansers, makeup removers, emulsions, creams, eyeliners, serums, ointments, oils, and face masks.

[0061] Examples of detergent compositions include oral (especially tooth) related detergents such as denture cleaners (liquids, powders, tablets, etc.), hair related detergents such as shampoos, rinses, body washes, and conditioners, and general household detergents such as soaps, hand soaps, liquid detergents, kitchen detergents, dishwashing detergents, bathroom detergents, toilet cleaners, and pipe cleaners.

[0062] [Methods to instantly kill bacteria] According to another aspect of the present invention, a method for instantly and sufficiently sterilizing bacteria on a target (hereinafter also simply referred to as "the sterilization method of the present invention") is provided. The sterilization method of the present invention can instantly and sufficiently decompose bacteria by applying the instantaneous sterilization composition of the present invention to a target where bacteria are present, such as by coating. Examples of targets to which the instantaneous sterilization composition of the present invention is applied include the oral cavity (e.g., oral mucosa such as the buccal mucosa, tongue, gums, teeth, etc.), the surfaces of living bodies of humans and non-human animals such as hair and skin, dentures, tableware, kitchens, kitchen utensils, toilets, toilet supplies, bathrooms, bathroom supplies, pipes, furniture, walls, and other surfaces of living bodies. The amount of instantaneous sterilization composition applied to the target is not particularly limited as long as the effects of the present invention are achieved, but for example, the surface area of ​​the target is 1 cm². 2 For example, the amount per serving can be 0.01 to 2 g, preferably 0.05 to 1.5 g, and more preferably 0.1 to 1 g. [Examples]

[0063] The present invention will be described in more detail below based on examples, but the present invention is not limited to these examples. In Tables 1 and 2 below, the values ​​for each component represent mass % of the total mass of the instantaneous sterilization composition.

[0064] [Preparation of compositions for instantaneous sterilization] The components shown in Tables 1 and 2 below were mixed in the amounts shown in the same tables to prepare the instantaneous sterilization compositions for Examples 1 to 22 and Comparative Examples 1 to 7.

[0065] [Table 1]

[0066] [Table 2]

[0067] [Evaluation of instant sterilization effect] Streptococcus mutans strain JCM5705 was pre-cultured for 24 hours at 32.5°C using SCD medium (Daigo, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) to obtain a pre-culture solution. Next, the obtained pre-culture solution was prepared by reducing the bacterial count to 10 8 After diluting with physiological saline to a CFU / mL concentration, 1 / 100 volume of culture medium was added to each of the instantaneous sterilization compositions in the examples and comparative examples to allow contact between the pre-culture medium and each instantaneous sterilization composition. After 20 seconds, 1 mL of each instantaneous sterilization composition mixed with the culture medium was taken, serially diluted, and the resulting dilutions were inoculated onto MCTA medium (Becton Dickinson), and the number of viable cells was determined by the pour plate method. The pour plate method was performed by mixing and solidifying the dilution with agar medium in a petri dish and culturing under aerobic conditions at 32.5°C. After culturing, the number of colonies that had formed was visually measured and recorded as the log viable cell count. The results are shown in Tables 1 and 2.

[0068] As shown in Table 1, when using the instantaneous sterilization compositions of Examples 1 to 22, which are formulated with a combination of components (A) anionic surfactant, (B) phenolic bactericide, and (C) essential oil, the log viable cell count was 4.2 or less in all cases, even when the contact time with the pre-culture solution was extremely short at 20 seconds, indicating excellent instantaneous sterilization effect. On the other hand, the instantaneous sterilization compositions of Comparative Examples 1 to 7, which lack one or two of components (A) anionic surfactant, (B) phenolic bactericide, and (C), all had a log viable cell count of 5.3 or more when the contact time with the pre-culture solution was extremely short at 20 seconds, indicating inferior instantaneous sterilization effect.

[0069] Furthermore, the instantaneous sterilization effect of each instantaneous sterilization composition in Example 1 and Comparative Example 4 was evaluated using the same method as described above, except that the contact time between the pre-culture solution and the instantaneous sterilization composition was changed from 20 seconds to 3 minutes. The log viable cell count for each instantaneous sterilization composition in Example 1 and Comparative Example 4 was <1.0. These results indicate that each instantaneous sterilization composition in Example 1 and Comparative Example 4 exhibits excellent sterilization effects when the contact time with the pre-culture solution is relatively long, at 3 minutes. These results, along with the results shown in Table 1, suggest that a superior instantaneous sterilization effect is achieved only when the components of component (A) anionic surfactant, component (B) phenolic bactericide, and component (C) essential oil are combined.

[0070] [Example prescription] This specification shows examples of formulations of the instantaneous sterilization composition of the present invention, prepared by mixing the components described herein. The units of the amount of each component are in mass%, with the entire instantaneous sterilization composition being 100% by mass.

[0071] <Example prescription 1: Gel toothpaste> Sodium lauroyl sarcosinate 0.3 Thymol 0.05 Menthol 0.1 Camphor 0.05 Cetylpyridinium chloride 0.05 Isopropylmethylphenol 0.1 Hydroxyethylcellulose 1.0 Sodium hydroxide 0.4 Sodium fluoride 0.1 70% sorbitol solution 10 Concentrated glycerin 30 Dipotassium glycyrrhizinate 0.1 Polyoxyethylene hydrogenated castor oil 0.5 Glycerin fatty acid ester 0.5 Sodium hyaluronate 0.01 Terpinene 0.05 Terpineol 0.05 Fragrance 0.9 Purified water remainder Total 100% by mass

[0072] <Prescription Example 2: Toothpaste> Sodium lauryl sarcosinate 0.3 Sodium lauroyl methyl taurate 0.5 Thymol 0.05 Isopropylmethylphenol 0.1 Menthoxypropanediol 0.5 Camphor 0.05 Silica 10 Calcium carbonate 1.0 Sodium dihydrogen phosphate 1.0 Titanium dioxide 0.3 Sodium carboxymethylcellulose 1.5 Cetylpyridinium chloride 0.05 Sodium monofluorophosphate 0.1 Sodium saccharin 0.1 70% sorbitol solution 10 Concentrated glycerin 20 Polyoxyethylene hydrogenated castor oil 2.0 Ethanol 1.0 Limonene 0.05 Carvacrol 0.05 Fragrance 0.9 Purified water remainder Total 100% by mass

[0073] <Prescription Example 3: Liquid Toothpaste> Sodium lauroyl sarcosinate 0.3 Isopropylmethylphenol 0.1 Thymol 0.05 Camphor 0.05 Menthol 0.05 Cetylpyridinium chloride 0.05 Sodium hydroxide 0.42 Xylitol 1.0 Dipotassium glycyrrhizinate 0.1 Concentrated glycerin 30 Polyoxyethylene hydrogenated castor oil 2.0 Geraniol 0.05 Eugenol 0.05 Fragrance 0.9 Purified water remainder Total 100% by mass

[0074] <Prescription Example 4: Non-water-based toothpaste> Sodium tetradecenesulfonate 0.5 Hinokitiol 0.1 Menthol 0.5 Cetylpyridinium chloride 0.05 Anhydrous silicic acid 10 Hydrated silica 5.0 Titanium dioxide 1.0 Hydroxypropylcellulose 1.0 Hydroxypropyl methylcellulose 1.0 Polyvinylpyrrolidone 1.0 Sodium fluoride 0.1 Glycyrrhetinic acid 0.1 Sodium saccharin 0.1 Sodium lauryl sulfate 1.5 Concentrated glycerin 20 Glycerin fatty acid ester 0.5 Citral 0.05 Limonene 0.05 Fragrance 0.9 Propylene glycol remainder Total 100% by mass

Claims

1. (A) Anionic surfactant, (B) Phenolic fungicides, and (C) Components of essential oils A composition for instantaneous sterilization containing the following:

2. The instantaneous sterilization composition according to claim 1, comprising essential oils.

3. The instantaneous sterilization composition according to claim 1, wherein the (A) anionic surfactant contains at least one selected from the group consisting of sodium lauroyl sarcosinate, sodium lauryl sulfate, sodium lauroyl methyl taurate, and sodium tetradecenesulfonate.

4. The instantaneous sterilization composition according to claim 1, wherein the (B) phenolic disinfectant contains at least one selected from the group consisting of thymol, isopropylmethylphenol, and hinokitiol.

5. (C) The instantaneous sterilization composition according to claim 1, wherein the essential oil contains at least one selected from the group consisting of menthol, terpinene, citral, menthoxypropanediol, carvacrol, terpineol, limonene, geraniol, eugenol, and camphor.

6. The instantaneous sterilization composition according to claim 1, wherein the content of the anionic surfactant (A) is 0.001 to 5% by mass relative to the total mass of the instantaneous sterilization composition.

7. The instantaneous sterilization composition according to claim 1, wherein the content of the phenolic disinfectant (B) is 0.0005 to 10% by mass relative to the total mass of the instantaneous sterilization composition.

8. (C) The instantaneous sterilization composition according to claim 1, wherein the content of the essential oil components is 0.0005 to 10% by mass relative to the total mass of the instantaneous sterilization composition.

9. A composition for instantaneous sterilization according to claim 1, used for sterilization in the oral cavity.

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