Sunscreen compositions for protecting the skin microflora

Abstract

The present invention relates to a sunscreen or daily care composition for use in a method for protecting the skin microflora from damage caused by UV light radiation, comprising a first UV filter which is hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate); and a second UV filter which is selected from the group consisting of (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyltriazone), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine), and mixtures thereof.

Description

[Technical Field]

[0001] The present invention relates to sunscreen or daily care compositions comprising specific UV filters for use in a method for protecting the skin microbiota from damage caused by UV light irradiation, as well as to these sunscreen or daily care compositions for use in a method for increasing the survival of the skin microbiota under UV light irradiation, and to combinations of UV filters for use in a method for protecting the skin microbiota from UV radiation. [Background technology]

[0002] UV radiation causes harmful effects on human skin. In addition to the acute effect of sunburn, UV radiation is also known to increase the risk of skin cancer. Furthermore, long-term exposure to UV-A and UV-B light can cause phototoxic and photoallergic reactions in the skin and can accelerate skin aging.

[0003] To protect human skin from UV radiation, various sun-protective UV filters (also called UV absorbers) exist, including UV-A filters (also called UVA filters), UV-B filters (also called UVB filters), and broadband filters. These filters are added to sunscreen or daily care compositions. UV filters are organic or inorganic particulate or non-particulate compounds, all of which have high absorption efficiency in the UV light range. Generally, UV light relevant to skin health can be divided into UV-A radiation (320-400 nm) and UV-B radiation (290-320 nm). UV filters are divided into UV-A filters and UV-B filters depending on the location of their absorption maxima. When a UV filter absorbs both UV-A and UV-B light, it is called a broadband absorber.

[0004] Since 2006, the EU Commission has recommended that all sunscreens must have a UV-A protection factor (SPF) of at least one-third of the declared sun protection factor (SPF), which primarily refers to UV-B protection. The same needs to apply to daily care compositions with UV protection in order to effectively protect consumers from long-term UV damage caused by UV-A radiation.

[0005] Human skin contains millions of bacteria, fungi, and viruses that constitute the skin microbiome. These organisms play an essential role in defense against, for example, the invasion of pathogens. If the barrier provided by these organisms is destroyed, humans become vulnerable to the invasion of pathogens. For example, it is known that compounds contained in cosmetics tend to destroy the barrier.

[0006] Furthermore, the skin microbiota is also directly damaged by UV radiation, which can affect the health of the skin microbiota and significantly reduce the number of microorganisms that provide beneficial defense of human skin against pathogens.

[0007] Therefore, there is a need to find sunscreen compositions that can effectively protect the microorganisms of the skin microflora from damage caused by UV light irradiation, and at the same time, these sunscreen compositions must be compatible with the skin microflora.

[0008] It was an object of the present invention to provide a sunscreen or daily care composition that protects the skin microbiota from damage caused by UV light irradiation.A further object of the present invention was to provide a sunscreen or daily care composition that does not have a negative effect on the microbiota.A further object of the present invention was to provide a sunscreen or daily care composition that contains a UV filter that is well compatible with the skin microbiota.A further object of the present invention was to provide a sunscreen or daily care composition that increases the survival of the skin microbiota under UV light irradiation. Summary of the Invention [Means for solving the problem]

[0009] It has surprisingly been found that at least one of these objectives can be achieved by a sunscreen or daily care composition comprising: a first UV filter which is hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate); and a second UV filter selected from the group consisting of (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyltriazone), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine), and mixtures thereof.

[0010] Surprisingly, it has been found that sunscreen or daily care compositions comprising this particular combination of UV filters are highly suitable for protecting the skin microflora from UV radiation, whereas sunscreen or daily care compositions comprising different UV filters do not provide the same level of protection against damage to the skin microflora from UV radiation.

[0011] According to a first aspect, the present invention provides a composition for use in a method for protecting the skin microflora from damage caused by UV light irradiation, comprising: a first UV filter which is hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate); and a second UV filter selected from the group consisting of (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyltriazone), 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine), and mixtures thereof; The present invention relates to a sunscreen or daily care composition comprising:

[0012] According to a second aspect, the present invention provides a method for increasing the survival of the skin microbiota under UV light irradiation, comprising: a first UV filter which is hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate); and a second UV filter selected from the group consisting of (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyltriazone), 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine), and mixtures thereof; The present invention relates to a sunscreen or daily care composition comprising:

[0013] According to a third aspect, the present invention relates to a UV filter combination of hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate) with 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine) and / or (Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyltriazone) for use in a method for protecting the skin microflora against UV radiation.

[0014] Preferred embodiments of the above aspects are described in further detail below, and it should be understood that each preferred embodiment is suitable both alone and in combination with other preferred embodiments.

[0015] Statements made herein with respect to the features of the first aspect of the invention also apply to the other aspects of the invention, and vice versa. Thus, features such as the components of sunscreen or daily care compositions used, or specifications of the properties of these compositions discussed with respect to one aspect of the invention, apply equally to the other aspects of the invention. [Brief explanation of the drawings]

[0016] [Figure 1] 1 shows the results of a survival test on S. epidermidis and different cosmetic formulations under different conditions. [Figure 2] 1 shows the results of a survival test on S. hominis and various cosmetic formulations under various conditions. [Figure 3] 1 shows the results of a survival test on C. acnes and various cosmetic formulations under various conditions. DETAILED DESCRIPTION OF THE INVENTION

[0017] definition As used in this specification and the appended claims, the singular forms "a" and "an" also include the respective plural forms, unless the context clearly dictates otherwise. In the context of the present invention, the terms "about" and "approximately" refer to a margin of accuracy that a person skilled in the art would recognize, provided that the technical effect of the feature in question is still ensured. This term typically refers to a deviation of ±20%, preferably ±15%, more preferably ±10%, and even more preferably ±5% from the indicated numerical value. The term "comprising" should be understood to be open-ended. The term "consisting of" for the purposes of the present invention is considered to be a preferred embodiment of the term "comprising of". Hereinafter, if a group is defined as comprising at least a certain number of embodiments, this also means that the group preferably consists only of these embodiments. Furthermore, the terms "first," "second," "third," "(a)," "(b)," "(c)," "(d)," and similar terms used in the specification and claims are used to distinguish between similar elements and do not necessarily describe sequential or chronological order. It should be understood that terms so used are interchangeable under appropriate circumstances, and that the embodiments of the invention described herein may be performed in orders other than those described or illustrated herein. In the case of terms such as "first," "second," "third," or "(a)," "(b)," "(c)," "(d)," "i," "ii," and the like, referring to steps of a method, use, or assay, unless otherwise indicated in this application, as described herein above or below, there is no time gap or inconsistency between the steps, i.e., the steps may be performed simultaneously, or there may be time gaps of seconds, minutes, hours, days, weeks, months, or years between such steps. It should be understood that the invention is not limited to the specific methods, procedures, reagents, and the like described herein, as these may vary.It should also be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention, which will be limited only by the appended claims. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art.

[0018] As used herein, the term "does not comprise" or "free of," in the context of the composition of the present invention not comprising a specific compound or group of compounds that may be combined under a generic term, means that the composition does not comprise said compound or group of compounds in an amount greater than 0.8% by weight, based on the total weight of the composition. Furthermore, it is preferred that the composition according to the present invention does not comprise said compound or group of compounds in an amount greater than 0.5% by weight, and it is preferred that the composition is completely free of said compound or group of compounds.

[0019] When referring to weight percentages of compositions and the ingredients contained therein, it should be understood that, according to the present invention, the total amount of ingredients does not exceed 100% (±1% rounded).

[0020] The term "cosmetic composition" refers to any topical product intended to be applied to the human body to cleanse, beautify, promote attractiveness, change the appearance, or protect the skin, without affecting the structure or function of the body. Possible cosmetic compositions within the meaning of the present invention include leave-on and rinse-off products, such as face and body care, including daily care compositions with or without UV protection and sunscreen or sunscreen compositions, hair care products, such as shampoos, conditioners, shower gels, makeup compositions, and similar compositions.

[0021] The term "sunscreen composition" or "sunscreen" refers to any topical product that can absorb a specific portion of UV radiation and further reflect and scatter it. Therefore, it should be understood that the term "sunscreen composition" not only includes sunscreen compositions, but also any cosmetic composition that provides UV protection. The term "topical product" refers to a product that is applied to the skin, and may refer to, for example, a spray, lotion, cream, oil, foam, powder, or gel. According to the present invention, the sunscreen composition may contain one or more active agents, such as organic and inorganic UV filters, and other ingredients or additives, such as emulsifiers, emollients, viscosity modifiers, stabilizers, preservatives, or fragrances.

[0022] The term "daily care composition" refers to any topical product intended for daily use, with or without UV protection. When UV protection is included, the daily care composition can absorb a certain portion of UV radiation and further reflect and scatter it, and is used as a daily care product for the human body, for example, face or body. The daily care composition may contain one or more active agents, such as organic and / or inorganic UV filters, and other ingredients or additives, such as emulsifiers, emollients, viscosity adjusters, stabilizers, preservatives, or fragrances. Suitable daily care compositions are those according to the present invention, for example, leave-on face and body care products.

[0023] Suitable leave-on products for the face and body are, for example, sunscreen compositions, cosmetic preparations, and skin care preparations.

[0024] Suitable cosmetic preparations are, for example, lipsticks, nail varnishes, eye shadows, mascaras, dry and moist make-up foundations, rouge, powders.

[0025] Suitable skin care formulations are, for example, moisturizing formulations, refining formulations, and lifting formulations.The leave-on compositions mentioned here can be in the form of creams, ointments, pastes, foams, gels, lotions, powders, sprays, sticks, or aerosols.The daily care compositions with UV protection protect human skin from damage caused by UV rays.

[0026] As used herein, the term "UV filter" or "ultraviolet filter" refers to an organic or inorganic compound that can absorb, reflect, and scatter UV radiation generated by sunlight. UV filters can be classified into UV-A, UV-B, or broadband filters based on their UV absorbance profile. Preferably, the term "UV filter" includes or consists of any UV filter as defined in Annex VI of Regulation (EC) No. 1223 / 2009 of the European Parliament and of the Commission (ed. 11.11.2022).

[0027] The solubility of the water-soluble UV filter in water is at least 2% by weight, preferably at least 3% by weight, more preferably at least 5% by weight.

[0028] The solubility of the oil-soluble filter in a particular emollient is at least 2% by weight, preferably at least 3% by weight, and more preferably at least 5% by weight.

[0029] The prefixes Cn to Cm indicate in each case the possible number of carbon atoms in the group.

[0030] The term "C12-C15 alkyl benzoate" refers to an ester of benzoic acid with a fatty alcohol comprising a C12-C15 alkyl chain. A C12-C15 alkyl chain is defined as an alkyl chain having a chain length of C12, C13, C14, or C15.

[0031] As used herein, the term "Cn-Cm carboxylic acid" refers in each case to a straight-chain or branched carboxylic acid having n to m carbon atoms, for example 6 to 24 carbon atoms.

[0032] The term "Cn-Cm alcohol" as used herein refers to a linear or branched alcohol having in each case n to m carbon atoms, for example, 3 to 24 carbon atoms or 6 to 24 carbon atoms or 1 to 22 carbon atoms.

[0033] The term "C2-C12 dicarboxylic acid" as used herein refers in each case to a dicarboxylic acid having 2 to 12 carbon atoms, such as butanedioic acid (succinic acid), pentanedioic acid (glutaric acid), hexanedioic acid (adipic acid) or decanedioic acid (sebacic acid).

[0034] As used herein, the term "dialkyl ether" refers to a straight-chain or branched dialkyl ether, in each instance, having a total of 12 to 36 carbon atoms and containing at least one ether moiety.

[0035] As used herein, the term "C6-C22 alcohol carbonate" refers to a linear or branched alcohol carbonate, in each case having 6 to 22 carbon atoms and containing at least one functional group consisting of a carbonyl group flanked by two alkoxy groups.

[0036] The term "alkyl" as used herein, in each case, illustratively refers to a straight-chain or branched alkyl group having 1 to 18 carbon atoms. Examples of alkyl groups are methyl, ethyl, n-propyl, isopropyl, n-butyl, 2-butyl, isobutyl, tert-butyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, n-hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl, and 1-ethyl-2-methylpropyl.

[0037] The term "alkoxy" as used herein refers in each case to a straight-chain or branched alkyl group bonded via an oxygen atom and typically having 1 to 20 carbon atoms. Examples of alkoxy groups are methoxy, ethoxy, n-propoxy, isopropoxy, n-butyloxy, 2-butyloxy, isobutyloxy, tert-butyloxy, etc.

[0038] The term "carboxyalkyl" as used herein includes carboxymethyl, carboxyethyl, carboxypropyl, carboxyisopropyl, carboxybutyl, carboxyisobutyl, carboxyamyl, carboxyhexyl, carboxyheptyl, carboxyoctyl, carboxyisooctyl, carboxynonyl, carboxydecyl, carboxyundecyl, carboxydodecyl, carboxytetradecyl, carboxyhexadecyl and carboxyoctadecyl, with carboxymethyl being preferred.

[0039] The term "cycloalkyl" as used herein refers to a monocyclic alicyclic group, typically having 3 to 10 or 5 to 8 carbon atoms, in each case, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, and cyclodecyl, or cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl.

[0040] As used herein, the term "substituted" means that a hydrogen atom bonded to a designated atom is replaced with a specified substituent, provided that the substitution results in a stable or chemically feasible compound. Unless otherwise indicated, a substituted atom can have one or more substituents, and each substituent is independently selected.

[0041] The term "emollient" relates to certain cosmetic oils used to protect, moisturize and smooth the skin. The word emollient comes from the Latin "mollire" (to soften). Generally, emollients prevent the evaporation of water from the skin by forming an occlusive coating. Alternatively or additionally, emollients improve the distribution of the product on the skin. Emollients can be divided into different groups depending on their polarity index.

[0042] The term "sensitive skin" refers to skin whose natural barrier function has been weakened and disrupted by certain triggers, which can be, for example, cold weather, extremely hot water, and potentially dangerous ingredients contained in sunscreen or daily care compositions.

[0043] The term "sun protection factor (SPF)" used herein refers to how well a sunscreen composition protects skin, primarily from UV-B radiation. Specifically, this index indicates how long protected skin can be exposed to sunlight without sunburn, compared to untreated skin. For example, if a sunscreen composition with SPF 15 is evenly applied to the skin of a person who normally burns after 10 minutes in the sun, the sunscreen will allow the person skilled in the art to stay in the sun 15 times longer. In other words, SPF 15 means that, assuming a uniform application of the sunscreen at a dose thickness of 2 milligrams per square centimeter (mg / cm2), 1 / 15 of the UV radiation that would cause a burn will reach the skin.

[0044] The definition of "broadband" protection (also called broad spectrum or broad-spectrum protection) can be, for example, based on the "critical wavelength" or UVA-PF. Broad-band coverage requires that UV-B and UV-A protection be provided. According to US requirements, a critical wavelength of at least 370 nm is required to achieve broad-spectrum protection. Furthermore, the European Commission recommends that all sunscreen or cosmetic compositions should have a UV-A protection factor of at least one-third of the labeled sun protection factor (SPF); for example, if a sunscreen composition has an SPF of 30, the UVA protection factor must be at least 10.

[0045] The term "critical wavelength" is defined as the wavelength at which the area under the UV protection curve (protection rate (%) vs. wavelength) is 90% of the total area under the curve in the UV region (290-400 nm). For example, a critical wavelength of 370 nm indicates that protection by a sunscreen composition is not limited to UV-B wavelengths, i.e., wavelengths from 290 to 320 nm, but extends up to 370 nm, so that 90% of the total area under the protection curve in the UV region is reached at a minimum of 370 nm.

[0046] The term "administering" refers to applying a sunscreen or daily care composition to human skin.

[0047] Specific Embodiments of the Invention A first aspect of the present invention relates to a method for protecting the skin microflora from damage caused by UV light irradiation, comprising: a first UV filter which is hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate); and a second UV filter selected from the group consisting of (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyltriazone), 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine), and mixtures thereof; The present invention relates to a sunscreen or daily care composition comprising:

[0048] Surprisingly, it has been found that sunscreen or daily care compositions comprising diethylaminohydroxybenzoylhexylbenzoate (DHHB) in combination with bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT) and / or ethylhexyl triazone (EHT) effectively protect the skin microflora from damage caused by UV light irradiation. Interestingly, this particular combination of UV filters in a sunscreen or daily care composition is better suited to protecting the skin microflora from damage caused by UV light irradiation than alternative UV filter combinations.

[0049] As mentioned above, the skin microbiota is composed of a large number of organisms and is important for protecting mammals (e.g., humans) from pathogens. UV radiation is known to adversely affect the skin microbiota. Furthermore, several compounds are known to adversely affect the skin microbiota. It should be understood that "protecting the skin microbiota from damage caused by UV light radiation" means that the composition of the present invention contains a combination of specific UV filters that, when exposed to UV radiation, maintains a larger microbial population than the exact same composition without the specific UV filter combination. It should be understood that "increasing the compatibility of a sunscreen or daily composition with the skin microbiota" according to the present invention means that a composition of the present invention containing one of the specific UV filters has a larger microbial population than the exact same composition without the specific UV filter. Suitable representatives of the microorganisms of the skin microflora are, for example, Cutibacterium acnes, Staphylococcus epidermidis, Staphylococcus hominis, Micrococcus luteus, and Corynebacterium jeikeium.

[0050] According to a preferred embodiment, the present invention provides a method for the prevention and treatment of Cutibacterium acnes, Cutibacterium granulosum, Cutibacterium avidum, Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus hominis, Staphylococcus xylosus, Staphylococcus warneri, Staphylococcus haemolyticus, Staphylococcus saccharo ... saccharolyticus, Staphylococcus conii, Staphylococcus auricularis, Micrococcus luteus, Corynebacterium minutissimum, Corynebacterium jeikeium, Corynebacterium tuberculostearicum, Corynebacterium fastidiosum, Corynebacterium simulans, Corynebacterium amycolatum amycolatum, Corynebacterium xerosis, Streptococcus mitis, Streptococcus sanguinisThe present invention relates to a sunscreen or daily care composition for use in a method for protecting a population of bacteria selected from the group consisting of Streptococcus sanguinis, Streptococcus oralis, Brevibacterium spp., Pseudomonas spp., and mixtures thereof from damage caused by UV light irradiation.

[0051] According to a particularly preferred embodiment, the present invention relates to a sunscreen or daily care composition for use in a method for protecting the bacterial populations of Staphylococcus hominis, Staphylococcus epidermidis, Cutibacterium acnes and mixtures thereof in the skin microbiome from damage caused by UV light irradiation.

[0052] According to another preferred embodiment, the present invention relates to a sunscreen or daily care composition for use in a method for protecting a population of fungi selected from the group consisting of Malassezia furfur, Malassezia restricta, Malassezia globosa, Candida spp., and mixtures thereof in the skin microbiome from damage caused by UV light irradiation.

[0053] According to another preferred embodiment, the sunscreen or daily care composition preferably comprises 4-4'-[[6-[[4-[[(1,1-dimethylethyl)amino]carbonyl]phenyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-benzoic acid-bis(2-ethylhexyl)ester (INCI Diethylhexylbutamidotriazone or DBT), phenyl-3H-benzimidazole-5-sulfonic acid (INCI Phenylbenzimidazolesulfonic acid or PBSA), dimethicone diethylbenzylmalonate (INCI Polysilicone-15), 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]phenol (INCI and mixtures thereof. Of these preferred additional UVB and broadband filters, phenyl-3H-benzimidazole-5-sulfonic acid (INCI Phenylbenzimidazole Sulfonic Acid or PBSA) is particularly preferred.

[0054] In another preferred embodiment of the present invention, the sunscreen or daily care composition comprises 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol] (INCI methylenebis-benzotriazolyltetramethylbutylphenol), 2,4,6-tris(biphenyl-4-yl)-1,3,5-triazine (INCI tris-biphenyltriazine), 5,6,5',6'-tetraphenyl-3-3'-(1,4-phenylene)bis(1,2,4-triazine) (INCI phenylenebis-diphenyltriazine), 1,1'-(1,4-piperazinediyl)bis[1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methanone (INCI Preferably, the sunscreen or daily care composition further comprises at least one organic micronized UV filter selected from the group consisting of (3R,4S,5S,6R)-2-(decyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (INCI decyl glucoside), preferably 2,2'-methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-(2H-benzotriazol-2-yl)phenol] (INCI methylenebis-benzotriazolyltetramethylbutylphenol) and / or 2,4,6-tris(biphenyl-4-yl)-1,3,5-triazine (INCI tris-biphenyltriazine). If the sunscreen or daily care composition comprises such an organic micronized UV filter, it is preferred that the at least one organic micronized UV filter is not dispersed in (3R,4S,5S,6R)-2-(decyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (INCI decyl glucoside).

[0055] In a preferred embodiment, the organic micronized UV filter is dispersed in a polyglycerol monoalkyl ester. Preferably, the polyglycerol monoalkyl ester is selected from the group consisting of decaglyceryl caprate, decaglyceryl monolaurate, decaglyceryl myristate, decaglyceryl oleate, decaglyceryl stearate, decaglyceryl isostearate, hexaglyceryl caprate, hexaglyceryl laurate, hexaglyceryl myristate, hexaglyceryl oleate, hexaglyceryl stearate, hexaglyceryl isostearate, pentaglyceryl caprate, pentaglyceryl laurate, pentaglyceryl myristate, pentaglyceryl oleate, pentaglyceryl stearate, pentaglyceryl isostearate, and mixtures thereof; more preferably, the at least one polyglycerol monoalkyl ester is decaglyceryl monolaurate (INCI Polyglyceryl-10 Laurate).

[0056] According to another preferred embodiment, the sunscreen or daily care composition preferably contains a phenyl dibenzimidazole tetrasulfonic acid (INCI terephthalylidene dicamphorsulfonic acid), disodium phenyl dibenzimidazole tetrasulfonate, 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione (INCI butylmethoxydibenzoylmethane), and mixtures thereof, in particular 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione (INCI butylmethoxydibenzoylmethane). butyl methoxydibenzoylmethane).

[0057] Particularly preferred is an embodiment in which the sunscreen or daily care composition does not contain zinc oxide (ZnO). Zinc oxide has been found to be harmful to the skin microflora. In another preferred embodiment, the sunscreen or daily care composition does not contain a zinc derivative compound. According to the present invention, a zinc derivative compound means any compound containing a zinc atom.

[0058] In a preferred embodiment, the sunscreen or daily care composition does not contain zinc salts. In a particularly preferred embodiment, the sunscreen or daily care composition does not contain zinc salts of pyrrolidone carboxylic acid.

[0059] In a preferred embodiment, the sunscreen or daily care composition is paraben-free.

[0060] In a preferred embodiment, the sunscreen or daily care composition does not contain PVP (polyvinylpyrrolidone) polymers and VP (vinylpyrrolidone) derivatives such as vinylpyrrolidone / hexadecene copolymer, VP / eicosene copolymer, triacontanyl PVP.

[0061] In a preferred embodiment, the sunscreen or daily care composition does not contain acrylic acid-based polymers such as, for example, but not limited to, compounds including INCI Carbomer, C10 / 30 Alkyl Acrylate Crosspolymer.

[0062] According to a preferred embodiment of the present invention, the sunscreen or daily care composition comprises hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate) in an amount of 0.1 to 10.0% by weight, preferably 0.5 to 8.0% by weight, in particular 1.0 to 5.0% by weight, based on the total weight of the sunscreen or daily care composition.

[0063] According to another preferred embodiment, the sunscreen or daily care composition comprises 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine) in an amount of 0.1 to 7.0% by weight, preferably 0.5 to 4.0% by weight, most preferably 1.0 to 3.0% by weight, based on the total weight of the sunscreen or daily care composition.

[0064] According to another preferred embodiment, the sunscreen or daily care composition comprises (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyltriazone) in an amount of 0.1 to 5.0% by weight, preferably 0.5 to 4.0% by weight, most preferably 0.8 to 3.0% by weight, based on the total weight of the sunscreen or daily care composition.

[0065] In a preferred embodiment, the sunscreen or daily care composition further comprises a dermatologically acceptable emulsifier, thickener, and / or emollient.

[0066] Preferred emulsifiers include: - Glucose derivatives such as cetearyl glucoside, arachidyl glucoside, lauryl glucoside, polyglyceryl-3 methylglucose distearate, methylglucose sesquistearate; - sucrose derivatives such as sucrose polystearate, sucrose palmitate; -sorbitol derivatives; -glycerides of fatty acids such as glyceryl stearate, glyceryl oleate; - Glutamic acid derivatives such as sodium stearoyl glutamate; - sulfosuccinic acid derivatives such as disodium cetearyl sulfosuccinate; -phosphate derivatives such as potassium cetyl phosphate; - Fatty acid esters of polyglyceryl such as polyglyceryl-3 diisostearate and polyglyceryl-2 dipolyhydroxystearate.

[0067] Preferred emollients include: - esters of linear or branched fatty alcohols with linear or branched fatty acids, such as propylheptyl caprylate, coco-caprylate, isopropyl myristate, ethylhexyl palmitate, etc.; - Esters of linear or branched fatty alcohols and aromatic carboxylic acids, such as C12-C15 alkyl benzoates, ethylhexyl benzoate, and phenethyl benzoate; -dicarboxylic acid esters with linear or branched alcohols, such as dibutyl adipate, dicaprylyl carbonate, diisopropyl sebacate, etc.; - esters of linear or branched fatty alcohols with hydroxycarboxylic acids; -esters of polyhydric alcohols, such as butylene glycol dicaprylate / dicaprate, with linear or branched fatty acids; -Mono-, di- and triglycerides based on C6-C18 fatty acids, such as caprylic / capric triglycerides and cocoglycerides; Guerbet alcohols such as octyldodecinol; - Hydrocarbons such as hydrogenated polyisobutene, mineral oil, squalene, isohexadecane, etc.; - ethers such as dicaprylyl ether; -Silicone derivatives such as dimethylpolysiloxane (organo-modified polysiloxane) Examples include:

[0068] Preferred thickeners include: -fatty alcohols such as cetyl alcohol, cetearyl alcohol, behenyl alcohol, stearyl alcohol; -Fatty acids such as stearic acid; -fatty acid esters such as myristyl stearate; -C18~38 alkyl hydroxystearoyl - Waxes such as beeswax, carnauba wax, microcrystalline wax, ceresin, ozokerite, Oryza Sativa (Oriza Sativa) and rice bran wax; - polysaccharides or derivatives such as xanthan gum, guar gum, agar gum, alginates, gellan gum, carrageenan, tara gum; -silicate derivatives such as magnesium silicate; -Cellulose derivatives such as hydroxypropyl cellulose Examples include:

[0069] In one embodiment, the sunscreen or daily care composition further comprises feel enhancers, adjuvants, preservatives and / or fragrances.

[0070] Preferred feel enhancers include: -silica; -mica; Starch derivatives such as starch octenylsuccinate Al, tapioca starch, Oryza Sativa starch, Zea mays (corn) starch; -Dimethicone derivatives; -boron nitride; -Perlite Examples include:

[0071] Preferred moisturizers include: -1,2 pentanediol; -1,2 hexanediol; -1,2 octanediol; -1,2-decanediol; 2-methyl-1,3-propanediol Examples include:

[0072] Preferred adjuvants include: -Tocopherol derivatives; -Retinol derivatives; -Ascorbic acid derivatives; -Bisabolol; -Allantoin; -Panthenol; -Chelating agents (EDTA, EDDS, EGTA, phytic acid, piroctone olamine); -Ethylhexylglycerin; -hydroxyacetophenone; -Caprylhydroxamic acid; - Propellants such as propane, butane, isobutene, dimethyl ether; - styrene / PVP or styrene-acrylamide copolymers; -Insect repellents such as butylacetylaminopropionate Examples include:

[0073] Preferred preservatives include: -benzyl alcohol; -Zingerone Examples include:

[0074] Preferred fragrances are limonene, citral, linalool, alpha-isomethyl ionone, geraniol, citronellol, 2-isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert.-pentylcyclohexyl acetate, 3-methyl-5-phenyl-1-pentanol, 7-acetyl-1,1,3,4,4,6-hexamethyltetralin, adipic acid diester, alpha-amyl cinnamaldehyde, alpha-methyl ionone, amyl C butylphenyl methylpropional cinnamal, amyl salicylate, amyl cinnamyl alcohol, anise alcohol, benzoin, benzyl alcohol, benzyl benzoate, benzyl cinnamate, benzyl salicylate, bergamot oil, bitter orange oil, butylphenyl methyl propioal (butylphenylmethylpropioal), cardamom oil, cedrol, cinnamal, cinnamyl alcohol, citronellyl methylcrotonate, lemon oil, coumarin, diethyl succinate, ethyl linalool, eugenol, evernia furfurracea extract, evernia prunustri extract, farensol, guajac wood oil, hexyl cinnamal, hexylcalicylate, hydroxycitronellal, lavender oil, lemon oil, linalyl acetate, mandarin oil, menthyl PCA, methylheptenone, nutmeg oil, rosemary oil, sweet orange oil, terpineol, tonka bean oil, triethyl citrate, vanillin, and combinations thereof.

[0075] In relation to the above preferred embodiments, it should be understood that when the sunscreen or daily care composition comprises two or more additives (e.g., emulsifiers, emollients, thickeners, feel enhancers, adjuvants, preservatives, fragrances), combinations of additives as defined above are also part of the present invention.

[0076] In connection with the above preferred and particularly preferred embodiments, it should be understood that the sunscreen or daily care composition may further comprise water.

[0077] It should be understood that when water is present in a sunscreen or daily care composition, it is preferably present in an amount greater than 5% by weight, based on the total weight of the composition. It should further be understood that when water is present in a sunscreen or daily care composition, the sunscreen or daily care composition may be an oil-in-water emulsion (O / W emulsion), a water-in-oil emulsion (W / O emulsion), a gel-cream, or an oil-in-gel.

[0078] In one embodiment of the present invention, the sunscreen or daily care composition can be provided in various forms, for example, in the form of a gel, cream, oil, lotion, or sprayable product.

[0079] The sunscreen and daily care compositions as outlined above are particularly suitable for sensitive skin.

[0080] The sunscreen or daily care composition may include typical sunscreen or daily care composition ingredients (e.g., emulsifiers, thickeners, emollients, feel enhancers, adjuvants, preservatives, and / or fragrances). Preferably, the sunscreen or daily care composition includes glycerol. Preferably, the sunscreen or daily care composition includes glycerol in an amount of 1 to 10% by weight, more preferably 2 to 8% by weight or 4 to 10% by weight, especially 5 to 8% by weight, based on the total weight of the sunscreen or daily care composition.

[0081] In a preferred embodiment, the sunscreen or daily care has an SPF value of 6 to 50+ (according to EC recommendations), the SPF being determined in silico (for example with a sunscreen simulator, https: / / sunscreensimulator.basf.com / ) or in vivo or in vitro.

[0082] According to a preferred embodiment of the present invention, the sunscreen or daily care composition does not contain 2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate (INCI Octocrylene), (RS)-2-ethylhexyl (2E)-3-(4-methoxyphenyl)prop-2-enoate (INCI Ethylhexyl Methoxycinnamate), 3-methylbutyl (2E)-3-(4-methoxyphenyl)prop-2-enoate (INCI Isoamyl p-methoxycinnamate) and / or homosalate, which UV filters have been identified as having adverse effects on human health and / or the environment and are therefore preferably excluded from the composition.

[0083] According to another embodiment, the sunscreen or daily care composition is used in a method for protecting the skin microflora from UV-A and / or UV-B radiation, preferably UV-A and UV-B radiation. The combination of UV filters present in the sunscreen or daily care composition for use according to the invention allows for sufficient protection of the skin microflora from UV-A and / or UV-B radiation.

[0084] It should be understood that the above-described embodiments of the sunscreen or daily care composition are also applicable to the second and third aspects of the invention, in particular with regard to the at least one additional UVB filter, at least one micronized UV filter, at least one additional UVA filter, further ingredients (e.g. emulsifiers, thickeners, emollients, feel enhancers, adjuvants, preservatives and / or fragrances) and their amount / weight ratios in the sunscreen or daily care composition.

[0085] A second aspect of the present invention relates to a method for increasing the survival of skin microbiota under UV light irradiation, comprising: a first UV filter which is hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate); and a second UV filter selected from the group consisting of (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyltriazone), 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine), and mixtures thereof; The present invention relates to a sunscreen or daily care composition comprising:

[0086] The term "increasing the survival of the skin microbiota under UV light irradiation" as used herein means that UV light irradiation on a sample of the sunscreen or daily care composition of the present invention reduces the reduction of microbial colonies of the skin microbiota more than a composition that does not contain the exact same combination of UV filters as the sunscreen or daily care composition of the present invention. When comparing two compositions, i.e., a first composition containing the combination of UV filters according to the present invention with a second composition containing the same components but not the specific combination of UV filters, the difference in the reduction of microbial colonies of the skin microbiota is at least 10%, preferably at least 20%, more preferably at least 50%, and most preferably at least 90% in colony count. The second composition may not contain any UV filters or may contain a different combination of UV filters.

[0087] The survival of microorganisms of the skin microflora is first controlled by controlling the survival of the microorganisms in the dark without any UV irradiation, and then by UV light irradiation, preferably 10 J / cm. 2 of UVA radiation and 40 mJ / cm 2 The colony count is determined as CFU / ml (CFU = colony forming units). Further details regarding the method for determining microbial survival according to the present invention are outlined in the Examples.

[0088] A third aspect of the invention relates to a UV filter combination of hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate) with 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine) and / or (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyltriazone) for use in a method for protecting the skin microflora from UV radiation.

[0089] Also, a first UV filter, a first UV filter which is hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate); and a second UV filter, a second UV filter selected from the group consisting of (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyltriazone), 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine), and mixtures thereof; A method for protecting the skin microflora from damage caused by UV light irradiation is described by applying to the skin a sunscreen or daily care composition comprising:

[0090] It also protects the skin microbiota from damage caused by UV light exposure. a first UV filter, a first UV filter which is hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate); and a second UV filter, a second UV filter selected from the group consisting of (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyltriazone), 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine), and mixtures thereof; The use of a sunscreen or daily care composition comprising the compound is also described.

[0091] The method and use also refers to the same sunscreen or daily care composition as used in the embodiments of the present invention. [Example]

[0092] The present invention is further illustrated by the following examples.

[0093] SPF rating SPF values ​​were calculated using the BASF Sunscreen Simulator (https: / / sunscreensimulator.basf.com / ).

[0094] Determining the effectiveness of sunscreen compositions to protect bacteria of the skin microbiota from UV radiation Bacteria: The bacterial strains used for the skin microbiota were Staphylococcus hominis (S. hominis), Staphylococcus epidermidis (S. epidermidis), and Cutibacterium acnes (C. acnes). Staphylococcus epidermidis strains ATCC 12228 and Staphylococcus hominis ATCC 27844 were obtained from the Pasteur Institute, France. These strains were grown aerobically in tryptic soy agar and tryptic soy broth (Biomerieux, France). Cutibacterium acnes ATCC 11828 was obtained from the Pasteur Institute, France, and was grown anaerobically on Schaedler agar supplemented with 5% sheep's blood or Schaedler broth (Biomerieux, France) supplemented with 0.5 g / L vitamin K3.

[0095] Study Design: Tryptic soy broth was inoculated with a colony of S. epidermidis or S. hominis and incubated at 37°C with continuous agitation at 150 rpm for 24 hours.

[0096] Then, 10 4 UFC / ml of S. epidermidis and 10 3 Suspension of UFC / ml of S. hominis was performed using PBS MgCl2 (1 g / L) CaCl2 (1.33 g / L).

[0097] For C. acnes, colonies were inoculated in Schaedler broth supplemented with vitamin K3 (0.5 g / L) at 37°C for 72 h without stirring. 4 Suspension of UFC / ml of C. acnes was performed using PBS MgCa.

[0098] 100 μL of these bacterial suspensions were spread onto Petri dishes containing tryptic soy agar for Staphylococci species or Schaedler agar for C. acnes. 100 μL of the formulation to be tested was then spread onto the Petri dishes already containing the bacteria. The Petri dishes were placed in the dark or in an irradiation chamber for the UV irradiation condition. The UV irradiation condition Petri dishes were exposed to 10 J / cm 2 of UV light. 2 UVA (320-400nm) and 40mJ / cm 2 Irradiation consisting of UVB (290-320 nm) was applied to the Petri dishes, which were then placed in an incubation chamber at 37°C for 24 hours in the case of S. hominis, 48 ​​hours in the case of S. epidermidis, and 96 hours in the case of C. acnes under aerobic conditions.

[0099] evaluation: Colonies were then counted and CFU / ml determined for each condition tested. Measurements were repeated four times per sample. Statistical analysis was performed using the Mann-Whitney rank sum test, with p<0.05 determined as statistically significant.

[0100] Composition: Formulations 1 to XY were prepared as follows: The ingredients of Part A and Part B were prepared separately, combined, and heated to 80°C with stirring. Part A was then added to Part B with stirring, and the combined mixture was then homogenized using an ultra turrax-type homogenizer. The homogenized mixture was allowed to cool to about 30°C, and then the pH value was adjusted to about 6.

[0101] The general composition of the formulations tested is shown in Table 1.

[0102] [Table 1]

[0103] In the control formulation without UV filters ("composition without UV filters"), the amount of the formulation belonging to the "UV filter combination" is replaced by water.

[0104] For UV filters, the following abbreviations are used: - 2-[4-(diethylamino)-2-hydroxybenzoyl]hexyl benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate) is "DHHB". - (Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyl Triazone) is "EHT". - 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine) is "BEMT". - 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione (INCI Butyl Methoxydibenzoylmethane) is "BMDBM". -2-Ethylhexyl 2-hydroxybenzoate (INCI Ethylhexyl Salicylate) is "EHS".

[0105] For S. epidermidis, the following UV filter combinations 2a-1 to 2a-4 shown in Table 2a were tested:

[0106] [Table 2]

[0107] Table 3a and Figure 1 show the results without any irradiation step (dark conditions) or with UV irradiation (UVA 10 J / cm 2 and UVB 40mJ / cm 2 ) and after UV irradiation. The composition without any UV filter protection resulted in a 100% reduction in S. epidermidis colonies under UV irradiation compared to the colony count without UV irradiation (in the dark), i.e., all colonies were destroyed by the harmful effects of irradiation. Both inventive formulations 2a-1 and 2a-3, containing DHHB and EHT or DHHB and BEMT, respectively, allowed statistically significantly higher survival of S. epidermidis under irradiated conditions than the two comparative formulations 2a-2 and 2a-4. This effect was particularly pronounced in the case of the combination of EHT and DHHB as UV filters (formulation 2a-1).

[0108] [Table 3]

[0109] For S. hominis, the following UV filter combinations 2b-1 to 2b-2 shown in Table 2b were tested:

[0110] [Table 4]

[0111] Table 3b and Figure 2 show the results without any irradiation step (dark conditions) or with UV irradiation (UVA 10 J / cm 2 and UVB 40mJ / cm 2Figure 1 shows the results of S. hominis from four measurements (N1 to N4) per formulation (formulations 2b-1 and 2b-2) measured either after UV irradiation or after UV irradiation. In the case of formulation 2b-1 of the present invention, the number of colonies was almost the same after UV irradiation as without UV irradiation, demonstrating how effective the inventive UV filter composition of DHHB and EHT is in protecting the skin microflora from the harmful effects of UV irradiation. In contrast, a significant decrease in S. hominis colony survival was observed in the UV irradiation assay with the comparative formulations BMDBM and EHT.

[0112] [Table 5]

[0113] For C. acnes, the following UV filter combinations 2c-1 to 2c-3 shown in Table 2c were tested:

[0114] [Table 6]

[0115] Table 3c and Figure 3 show the results without any irradiation step (dark conditions) or with UV irradiation (UVA 10 J / cm 2 and UVB 40mJ / cm 2 Figure 1 shows the results for C. acnes from four measurements (N1 to N4) per formulation (formulations 2b-1 and 2b-2) measured either after UV irradiation or after UV irradiation. Once again, the combination of EHT and DHHB proved highly effective in protecting microflora bacteria (here C. acnes) from UV irradiation. In contrast, comparative formulation 2c-2, which contains EHT and BMDBM as UV filters, resulted in more than 90% elimination of colony counts (10 in the dark). 3 from over 10 under UV irradiation 2It was shown that the survival of C. acnes colonies under UV irradiation was low even in the case of comparative formulation 2c-3 containing EHS and DHHB. Interestingly, this UV filter combination also lacked compatibility with the microorganisms prior to UV irradiation, as evidenced by the results in the dark, which already showed a significant reduction in C. acnes survival compared to the control formulation composition without UV filters.

[0116] [Table 7]

[0117] The results of Examples 2a-2c demonstrate that the combination of UV filters DHHB and EHT or DHHB and BEMT of the present invention was highly effective in protecting the skin microbiota from the damaging effects of UV radiation. All differences in Examples 2a-2c were statistically significant. The effect on the skin microbiota was demonstrated here with three different types of bacteria (S. epidermidis, S. hominis, and C. acnes). Sunscreen or daily care compositions containing this UV filter combination showed a higher level of protection against UV radiation for the skin microbiota than comparative sunscreen compositions containing other tested UV filter combinations. Furthermore, the sunscreen compositions of the present invention were compatible with the microorganisms of the skin microbiota.

[0118] In summary, the compositions of the invention are highly suitable for protecting the skin microflora from the harmful effects of UV radiation.

Claims

1. For use in a method for protecting the skin microflora from damage caused by UV light irradiation, a first UV filter, a first UV filter which is hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate); and a second UV filter, a second UV filter selected from the group consisting of (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyl Triazone), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine), and mixtures thereof; 1. A sunscreen or daily care composition comprising:

2. The sunscreen or daily care composition is effective in inhibiting the activity of Cutibacterium acnes, Cutibacterium granulosum, Cutibacterium avidum, Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus hominis, and the like in the skin microflora. hominis, Staphylococcus xylosus, Staphylococcus warneri, Staphylococcus haemolyticus, Staphylococcus saccharolyticus, Staphylococcus conii, Staphylococcus auricularis, Micrococcus luteus Corynebacterium luteus, Corynebacterium minutissimum, Corynebacterium jeikeium, Corynebacterium tuberculostearicum, Corynebacterium fastidiosum, Corynebacterium simulans, Corynebacterium amycolatum amycolatum, Corynebacterium xerosis, Streptococcus mitis, Streptococcus sanguinissanguinis, Streptococcus oralis, Brevibacterium spp., Pseudomonas spp. and mixtures thereof, preferably Staphylococcus hominis, Staphylococcus epidermidis, Cutibacterium acnes 10. The sunscreen or daily care composition of claim 1, wherein the sunscreen or daily care composition is for use in a method for protecting a population of bacteria selected from the group consisting of Malassezia furfur, Malassezia restricta, Malassezia globosa, Candida spp., and mixtures thereof from damage caused by UV light radiation, in the skin microflora.

3. The sunscreen or daily care composition preferably comprises 4-4'-[[6-[[4-[[(1,1-dimethylethyl)amino]carbonyl]phenyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-benzoic acid-bis(2-ethylhexyl)ester (INCI Diethylhexylbutamidotriazone or DBT), phenyl-3H-benzimidazole-5-sulfonic acid (INCI Phenylbenzimidazole Sulfonic Acid), dimethicone diethylbenzylmalonate (INCI Polysilicone-15), 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]phenol (INCI 3. A sunscreen or daily care composition according to claim 1 or 2, further comprising at least one additional UVB filter or broadband filter selected from the group consisting of phenyl-3H-benzimidazole-5-sulfonic acid (INCI phenylbenzimidazole sulfonic acid or PBSA), drometrizole trisiloxane, and mixtures thereof, in particular phenyl-3H-benzimidazole-5-sulfonic acid (INCI phenylbenzimidazole sulfonic acid or PBSA).

4. The sunscreen or daily care composition may comprise 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol] (INCI methylenebis-benzotriazolyltetramethylbutylphenol), 2,4,6-tris(biphenyl-4-yl)-1,3,5-triazine (INCI tris-biphenyltriazine), 5,6,5',6'-tetraphenyl-3-3'-(1,4-phenylene)bis(1,2,4-triazine) (INCI phenylenebis-diphenyltriazine), 1,1'-(1,4-piperazinediyl)bis[1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methanone (INCI 4. A sunscreen or daily care composition according to any one of claims 1 to 3, further comprising at least one organic micronised UV filter selected from the group consisting of 2,2'-methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-(2H-benzotriazol-2-yl)phenol] (INCI Methylenebis-benzotriazolyltetramethylbutylphenol) and / or 2,4,6-tris(biphenyl-4-yl)-1,3,5-triazine (INCI Tris-biphenyltriazine).

5. 5. The sunscreen or daily care composition of claim 4, wherein the at least one organic micronized UV filter is not dispersed in (3R,4S,5S,6R)-2-(decyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (INCI Decyl Glucoside) and / or the at least one organic micronized UV filter is dispersed in a polyglycerol monoalkyl ester.

6. The sunscreen or daily care composition preferably comprises [(3Z)-3-[[4-[(Z)-[7,7-dimethyl-2-oxo-1-(sulfomethyl)-3-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl]methanesulfonic acid (INCI terephthalylidene dicamphorsulfonic acid), disodium phenyldibenzimidazole tetrasulfonate, 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione (INCI butylmethoxydibenzoylmethane), and mixtures thereof, in particular 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione (INCI butylmethoxydibenzoylmethane).

6. The sunscreen or daily care composition according to any one of claims 1 to 5, further comprising at least one additional UVA filter selected from the group consisting of: butyl methoxydibenzoylmethane.

7. 7. The sunscreen or daily care composition according to any one of claims 1 to 6, wherein the sunscreen or daily care composition does not contain zinc oxide (ZnO).

8. The sunscreen or daily care composition comprises hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate) in an amount of 0.1 to 10.0 wt. %, preferably 0.5 to 8.0 wt. %, in particular 1.0 to 5.0 wt. %, based on the total weight of the sunscreen or daily care composition, and / or the sunscreen or daily care composition comprises 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI 8. A sunscreen or daily care composition according to any one of claims 1 to 7, comprising bis-ethylhexyloxyphenol methoxyphenyl triazine) in an amount of 0.1 to 7.0 wt. %, preferably 0.5 to 4.0 wt. %, in particular 1.0 to 3.0 wt. %, based on the total weight of the sunscreen or daily care composition.

9. 9. A sunscreen or daily care composition according to any one of claims 1 to 8, wherein the sunscreen or daily care composition comprises (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyl Triazone) in an amount of 0.1 to 5.0 wt. %, preferably 0.5 to 4.0 wt. %, based on the total weight of the sunscreen or daily care composition.

10. 10. The sunscreen or daily care composition according to any one of claims 1 to 9, wherein said sunscreen or daily care composition further comprises a dermatologically acceptable emulsifier, thickener and / or emollient.

11. 11. A sunscreen or daily care composition according to any one of claims 1 to 10, wherein the sunscreen or daily care composition does not contain 2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate (INCI Octocrylene), (RS)-2-ethylhexyl (2E)-3-(4-methoxyphenyl)prop-2-enoate (INCI Ethylhexyl Methoxycinnamate), 3-methylbutyl (2E)-3-(4-methoxyphenyl)prop-2-enoate (INCI Isoamyl p-methoxycinnamate), and / or homosalate.

12. 12. The sunscreen or daily care composition according to any one of claims 1 to 11, wherein the sunscreen or daily care composition is for protecting the skin microflora from UV-A radiation and / or UV-B radiation.

13. For use in a method for increasing the survival of skin microflora under UV light irradiation, a first UV filter, a first UV filter which is hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylaminohydroxybenzoylhexylbenzoate); and a second UV filter, a second UV filter selected from the group consisting of (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyl Triazone), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine), and mixtures thereof; 1. A sunscreen or daily care composition comprising:

14. 1. A combination of UV filters of hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Hexyl Diethylaminohydroxybenzoylbenzoate) with 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine) and / or (tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyltriazone) for use in a method for protecting the skin microflora from UV radiation.

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