Oral composition

Abstract

To provide a dextranase-containing oral composition that allows a user to feel great effect in a mouth, has a good taste, and is effective in preventing or inhibiting dental caries.SOLUTION: An oral composition contains (A) dextranase, (B) a water-soluble tin salt, and (C) at least one selected from a cationized cellulose (C1) and an α-olefin sulfonate (C2). The oral composition may further contain (D) a cold sensing agent.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a dextranase-containing oral composition which provides a high feeling of efficacy in the oral cavity and is effective for preventing or inhibiting dental caries. [Background technology]

[0002] Dextranase has the effect of chemically removing plaque by breaking down the water-insoluble glucan that forms plaque, and also has the effect of inhibiting plaque formation, so it has been incorporated into oral compositions as an ingredient for preventing or inhibiting dental caries (Patent Documents 1 to 4; JP 2011-132139 A, JP 2002-187829 A, JP 2001-163747 A, JP 2015-20970 A).

[0003] However, the above-mentioned action and effect of dextranase is difficult to recognize by visual inspection, and it is difficult to feel the effect of use, so that the user's motivation to use may not be maintained. In order to maximize the action and effect of dextranase, it is important to maintain the user's motivation to use and encourage continued use. For this purpose, it is considered effective to make the user feel that it is working in the oral cavity every time it is used, for example, by feeling a refreshing plaque removal, thereby increasing the user's motivation. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2011-132139 A [Patent Document 2] JP 2002-187829 A [Patent Document 3] JP 2001-163747 A [Patent Document 4] JP 2015-20970 A Summary of the Invention [Problem to be solved by the invention]

[0005] The present invention has been made in consideration of the above circumstances, and aims to provide an oral composition containing dextranase that provides a high sense of efficacy in the oral cavity and is effective for preventing or inhibiting dental caries. [Means for solving the problem]

[0006] As a result of intensive research by the present inventors to achieve the above object, they found that when a water-soluble tin salt and a cationized cellulose and / or an α-olefin sulfonate are combined in an oral composition containing dextranase, a unique and long-lasting remarkable refreshing feeling is imparted to the oral cavity, and thus not only the actual effect of removing plaque and inhibiting plaque formation can be imparted to the oral cavity with each use, but also a high level of effectiveness due to the refreshing feeling can be imparted and a good taste can be ensured. That is, in the present invention, it was found that an oral composition containing (A) dextranase, (B) a water-soluble tin salt, and (C) one or more selected from cationic cellulose (C1) and α-olefin sulfonate (C2) imparts a high level of effectiveness in the oral cavity even with a single use, has a good taste when used, and is effective for preventing or inhibiting dental caries, and thus the present invention was completed.

[0007] More specifically, in the present invention, by using the component (A) in combination with the component (B) in the oral cavity composition, a unique and long-lasting remarkable fresh feeling in the oral cavity (a distinctive sensation that the oral cavity is cleaned and continues to remain even after time has passed since use, which is sometimes abbreviated as "refreshing feeling in the oral cavity") can be imparted, and a high sense of effectiveness can be imparted. The fresh feeling in the oral cavity is a unique sensation that is specifically obtained by using the component (A) in combination with the component (B), and is different from the refreshing feeling obtained by, for example, a general oral flavor such as menthol or ethanol. Furthermore, when the component (A) is used in combination with the component (B), the bad aftertaste derived from the component (B) stands out as an unpleasant taste, and even if a general oral flavor is added, the aftertaste becomes unpleasant. However, by further adding the component (C), the unpleasant taste is suppressed without causing an unpleasant aftertaste as described above, and a good taste is ensured, and a high sense of effectiveness can be imparted by the refreshing feeling in the oral cavity. As shown in the comparative examples below, when the oral composition contains the (A) component but not the (B) and (C) components, the effect (refreshing feeling in the oral cavity, the refreshing feeling in the oral cavity immediately after use and 10 minutes after use) is low (Comparative Example 1), and when the oral composition contains the (A) and (B) components but not the (C) component, the lack of unpleasant taste after use is poor (Comparative Example 2). In contrast, the oral composition of the present invention containing the (A), (B) and (C) components shown in the examples had a high effect (refreshing feeling in the oral cavity) and a good lack of unpleasant taste after use. Patent Documents 1 and 2 show an improvement in the retention of dextranase in the oral cavity by a cationic polymer, Patent Document 3 shows an improvement in the inhibitory effect of dextranase on plaque reattachment by a cationic polymer, and Patent Document 4 shows oral biofilm removal by a combination of α-olefin sulfonic acid, dextranase, and sugar alcohol. In contrast, the present invention combines components (A), (B), and (C) to impart a unique, long-lasting, and remarkable feeling of freshness in the oral cavity, improving the perceived effect of component (A) and also improving the unpleasant taste.

[0008] Accordingly, the present invention provides the following oral compositions. [1] (A) dextranase, (B) Water-soluble tin salts and (C) one or more selected from cationic cellulose (C1) and α-olefin sulfonate (C2) An oral composition comprising: [2] (B) The oral composition according to [1], wherein the water-soluble tin salt is one or more selected from tin chloride and tin fluoride. [3] The oral composition according to [1] or [2], wherein the cationic cellulose (C1) is one or more selected from hydroxyethyl cellulose dimethyl diallyl ammonium chloride and O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethyl cellulose chloride. [4] The composition for oral cavity according to any one of [1] to [3], wherein the α-olefin sulfonate (C2) is sodium α-olefin sulfonate having 14 to 16 carbon atoms. [5] The oral composition according to any one of [1] to [4], wherein when the component (C) contains cationic cellulose (C1), the mass ratio of (B) (the amount of tin ions in component (B)) / (C1) is 0.3 to 30, and when the component (C) contains α-olefin sulfonate (C2), the mass ratio of (B) (the amount of tin ions in component (B)) / (C2) is 0.02 to 5. [6] The oral composition according to any one of [1] to [5], wherein, when the component (C) contains cationic cellulose (C1), the content thereof is 0.02 to 0.2 mass%, and when the component (C) contains α-olefin sulfonate (C2), the content thereof is 0.1 to 3 mass%. [7] The oral composition according to any one of [1] to [6], wherein the content of component (A) is 0.0077 to 1.54 mass %, and the content of component (B) is 0.02 to 1 mass % in terms of tin ions. [8] The oral composition according to any one of [1] to [7] further contains (D) one or more selected from N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate, and menthyl succinate. [9] The oral composition according to [8], wherein the content of component (D) is 0.00001 to 0.1 mass %.

[10] The oral composition according to any one of [1] to [9], which is a dentifrice, a mouthwash, or a mouth spray. Effect of the Invention

[0009] According to the present invention, it is possible to provide an oral composition that not only provides the actual effects of plaque removal and plaque formation inhibition by component (A), but also gives a high feeling of effectiveness that makes the user feel that component (A) is working, and also has a good taste. The oral composition of the present invention effectively exhibits the effects of plaque removal and plaque formation inhibition by component (A), and is effective for preventing or inhibiting dental caries. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The present invention will now be described in further detail. The oral composition of the present invention contains (A) dextranase, (B) a water-soluble tin salt, and (C) one or more members selected from cationic cellulose (C1) and α-olefin sulfonate (C2).

[0011] (A) Dextranase has the effect of chemically removing plaque by breaking down the water-insoluble glucan that forms plaque, and exerts the effects of removing plaque and inhibiting plaque formation. Dextranase having a concentration of 10,000 to 14,000 units / g is usually used, and when a dextranase having a concentration of 13,000 units / g is used, the amount of dextranase to be blended is preferably 0.0077 to 1.54% (mass%, the same applies below) of the entire composition, and more preferably 0.015 to 0.38%. The greater the amount of dextranase blended, the greater the effect of removing plaque and the effect of inhibiting plaque formation, but if the amount is too high, it may affect palatability, and a blending amount of 1.54% or less ensures a satisfactory taste. Furthermore, the content of the dextranase bulk substance in the composition is preferably 1 to 200 units / g, more preferably 2 to 20 units / g. Here, one unit of dextranase is the amount of dextranase that produces free reducing sugars equivalent to 1 μmol of glucose per minute when reacted with dextran as a substrate.

[0012] (B) Water-soluble tin salt, when used in combination with component (A), provides a unique, long-lasting and remarkable feeling of freshness in the oral cavity, and this freshness has the effect of imparting a sense of efficacy. (B) Examples of water-soluble tin salts include tin chloride, tin fluoride, tin acetate, tin gluconate, tin oxalate, tin sulfate, tin lactate, tin tartrate, tin citrate, tin malate, tin phosphate, tin pyrophosphate, and tin metaphosphate. Of these, tin chloride and tin fluoride are preferred. As the tin chloride, tin(II) chloride (stannous chloride) can be used, and it may be a hydrate such as tin(II) chloride dihydrate. As the tin fluoride, tin(II) fluoride (stannous fluoride) or tin(IV) fluoride (stannic fluoride) can be used. In particular, tin(II) fluoride (stannous fluoride) is preferred because it can also impart a caries prevention effect. These may be used alone or in combination of two or more.

[0013] The amount of the water-soluble tin salt (B) is preferably 0.02 to 1% of the total composition in terms of tin ions, more preferably 0.1 to 0.65%. If the tin ion content is 0.02% or more, a sufficiently refreshing feeling in the oral cavity is obtained, and if it is 1% or less, the unpleasant taste improving effect of the (C) component is fully exerted and the appearance stability is ensured.

[0014] The component (C) is at least one selected from the group consisting of (C) cationic cellulose (C1) and α-olefin sulfonate (C2), and the cationic cellulose (C1) and α-olefin sulfonate (C2) can also be used. The component (C) has the effect of improving the unpleasant taste caused by the combined use of the components (A) and (B).

[0015] Examples of the cationic cellulose (C1) include cellulose derivatives having dimethyldiallylammonium, 2-hydroxy-3-(trimethylammonio)propyl, etc., added as cationic groups. Examples include hydroxyethylcellulose dimethyldiallylammonium chloride, O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride, etc., and in particular, hydroxyethylcellulose dimethyldiallylammonium chloride is preferred from the viewpoint of improving unpleasant taste. The nitrogen content is preferably 0.1 to 3%, more preferably 0.5 to 2.5%. These may be used alone or in combination of two or more.

[0016] Specifically, hydroxyethyl cellulose dimethyl diallyl ammonium chloride is obtained by graft polymerization of dimethyl diallyl ammonium salt to hydroxyethyl cellulose, and a 2% aqueous solution having a viscosity of 10 to 3,000 mPa·s (BH type Brookfield viscometer, rotor No. 2, 20 rpm, 21°C) can be used. For example, AkzoNobel's Cellcoat L-200 (2% aqueous solution viscosity: 35 to 350 mPa·s, BH type Brookfield viscometer, rotor No. 2, 20 rpm, 21°C, measurement time 1 minute) and Cellcoat H-100 (2% aqueous solution viscosity: 500 to 2,750 mPa·s, BH type Brookfield viscometer, rotor No. 2, 20 rpm, 21°C, measurement time 1 minute) can be mentioned. In addition, Nouryon Japan's CELQUAT L-200 can also be used. In addition, the viscosity of O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethyl cellulose chloride can be measured in a 1% or 2% aqueous solution, and one with a viscosity of 500 to 2,600 mPa s for a 1% aqueous solution (BH Brookfield viscometer, rotor No. 2, 20 rpm, 25°C) or one with a viscosity of 5 to 800 mPa s for a 2% aqueous solution (BL viscometer, rotor No. 2, 30 rpm, 25°C) can be used. Examples include Leoguard KGP (viscosity of 2% aqueous solution: 5 to 50 mPa·s), Leoguard G (viscosity of 2% aqueous solution: 100 to 600 mPa·s), Leoguard GP (viscosity of 2% aqueous solution: 100 to 600 mPa·s), Leoguard LP (viscosity of 2% aqueous solution: 300 to 800 mPa·s), all manufactured by Lion Corporation, as well as Leoguard MGP (viscosity of 1% aqueous solution: 500 to 1,200 mPa·s) and Leoguard MLP (viscosity of 1% aqueous solution: 1,000 to 2,600 mPa·s).

[0017] When cationic cellulose (C1) is blended as component (C), its blending amount is preferably 0.02 to 0.2% of the total composition, more preferably 0.05 to 0.1%. When the blending amount is 0.02% or more, the unpleasant taste improving effect is sufficiently obtained and the unpleasant taste is suppressed. When the blending amount is 0.2% or less, the refreshing feeling in the oral cavity is sufficiently maintained, and the unpleasant taste (bitterness) of the composition itself is prevented from appearing, and the unpleasant taste improving effect is sufficiently maintained.

[0018] As the α-olefin sulfonate (C2), an alkali metal salt such as a sodium salt or potassium salt of an α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, and preferably an α-olefin sulfonate having 14 carbon atoms, particularly a sodium salt (generic name: sodium tetradecene sulfonate). These are commercially available products that can be used in oral preparations, and for example, the product name "K Lipolan PJ-400CJ" manufactured by Lion Specialty Chemicals Co., Ltd. can be used. When α-olefin sulfonate (C2) is blended as component (C), the blending amount is preferably 0.1 to 3% of the total composition, more preferably 0.4 to 2.5%, and even more preferably 0.4 to 2%. When the blending amount is 0.1% or more, the unpleasant taste improvement effect is sufficiently obtained and the unpleasant taste is suppressed. When the blending amount is 3% or less, the refreshing feeling in the oral cavity is sufficiently maintained, and the unpleasant taste (bitterness) of the composition itself is prevented from appearing, and the unpleasant taste improvement effect is sufficiently maintained.

[0019] In the present invention, the ratio of the blend amount of component (B) (as tin ions) to the blend amount of component (C) (components (C1) and / or (C2)) is preferably in the following range. When cationic cellulose (C1) is blended as component (C), the mass ratio of (B) / (C1) is preferably 0.3 to 30, more preferably 1.5 to 10. When the mass ratio of (B) / (C1) is within the above range, the oral cavity has a more excellent fresh feeling and the unpleasant taste improving effect is also more excellent. When the mass ratio of (B) / (C1) is less than 0.3, the stickiness of component (C1) adversely affects the oral cavity's fresh feeling, and the oral cavity may become less fresh, while when it exceeds 30, the unpleasant taste improving effect may not be obtained sufficiently. In addition, when α-olefin sulfonate (C2) is blended as component (C), the mass ratio of (B) / (C2) is preferably 0.02 to 5, more preferably 0.05 to 1.5. When the mass ratio of (B) / (C2) is within the above range, the fresh feeling in the oral cavity is more excellent and the effect of improving unpleasant taste is also more excellent. When the mass ratio of (B) / (C2) is less than 0.02, the degreasing feeling of component (C2) may adversely affect the fresh feeling in the oral cavity, and the fresh feeling in the oral cavity may be reduced.

[0020] The oral cavity composition of the present invention may further contain a cooling agent (D). The incorporation of component (D) enhances the refreshing feeling in the oral cavity, further improving the feeling of effectiveness. Examples of the (D) component include N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate, and menthyl succinate. Among these, N-(4-cyanomethylphenyl)-p-menthanecarboxamide and N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide) are preferred. These may be used alone or in combination of two or more.

[0021] Specifically, the following commercially available products can be used. N-Ethyl-p-menthane-3-carboxamide; Symrise, WS-3 Ethyl 3-(p-menthane-carboxamide) acetate; Toyotama Fragrance Co., Ltd., WS-5 N-(4-cyanomethylphenyl)-p-menthanecarboxamide: EVERCOOL 180, manufactured by Givaudan Japan Co., Ltd. N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide); EVERCOOL 190, manufactured by Givaudan Japan Co., Ltd. 2-Isopropyl-N,2,3-trimethylbutyramide; Givaudan Japan Co., Ltd., WS-23 Menthone glycerol acetal; Symrise, MGA Menthoxypropane-1,2-diol; Takasago International Corporation, CA10 Menthyl lactate; manufactured by Symrise Menthyl succinate (monomenthyl succinate); manufactured by Vimanfis

[0022] When component (D) is included, the amount added is preferably 0.00001 to 0.1%, more preferably 0.00003 to 0.07%, and particularly preferably 0.00005 to 0.05% of the total composition.

[0023] The oral cavity composition of the present invention can be prepared in the form of a paste, gel, liquid, etc., and used as a dentifrice such as toothpaste, gel dentifrice, liquid dentifrice, lubricant dentifrice, etc., a mouthwash, a spray, etc., for use. Among them, it is suitable as a dentifrice, a mouthwash, or a spray, particularly as a dentifrice. The preparation method can be a conventional method according to the form and dosage form. In this case, other optional components may be added as necessary in addition to the above-mentioned components depending on the purpose, dosage form, etc. of the oral composition. Examples of optional components include surfactants, abrasives, thickeners, humectants, solvents, sweeteners, flavorings, preservatives, colorants, active ingredients, etc. Specific examples of optional components are shown below. These optional components may be blended alone or in combination of two or more, and the blended amount of each optional component may be a normal amount within a range that does not impair the effects of the present invention.

[0024] Optional Surfactant: The surfactant may be an anionic surfactant other than the α-olefin sulfonate (C2), a nonionic surfactant, or an amphoteric surfactant, and specific examples thereof are shown in the following (i) to (iii). (i) Anionic surfactants Examples of the salt include alkyl sulfates such as lauryl sulfate, acyl sarcosine salts, acyl methyl taurine salts, and acyl glutamate salts. As the above salts, alkali metal salts such as sodium salts and potassium salts are preferred. (ii) Nonionic surfactants Examples of the fatty acid esters include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers, polyglycerin fatty acid esters, sorbitan fatty acid esters, and fatty acid monoglycerides. (iii) Amphoteric surfactants Examples of the fatty acid amidopropyl betaine include coconut oil fatty acid amidopropyl betaine and N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salts. The amount of the optional surfactant to be added is preferably 0.001 to 10%, particularly preferably 0.1 to 5%, of the total composition.

[0025] Abrasives: Examples of the abrasive include silica-based abrasives such as silicic anhydride, zeolite, calcium carbonate, aluminum hydroxide, and aluminum oxide. The amount of the abrasive blended is usually 2 to 50%, particularly 10 to 40%, of the entire composition.

[0026] Optional thickeners: The thickener may be an organic thickener other than the cationic cellulose (C1) or an inorganic thickener. Specific examples of the thickener include organic thickeners such as xanthan gum, sodium alginate, hydroxyethyl cellulose, carrageenan, sodium carboxymethyl cellulose, polyvinylpyrrolidone, sodium polyacrylate, and carboxyvinyl polymer, and inorganic thickeners such as thickening silica. The amount of any thickener blended is preferably 0.1 to 10%, particularly preferably 0.1 to 8%, of the total composition.

[0027] Wetting Agent: Examples of the alcohol include sugar alcohols such as sorbitol, xylitol, and erythritol, and polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol (PEG). The amount of the wetting agent is usually 2 to 50% of the entire composition.

[0028] solvent: Examples of the alcohol include purified water and lower alcohols having 1 to 3 carbon atoms, such as ethanol. When ethanol is added, it may be present in an amount of 25% or less of the entire composition, or it may not be added at all. Sweeteners: Examples include saccharin, sodium saccharin, and sucralose.

[0029] Fragrance: Examples of such oils include menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, and eucalyptus oil. These may be used alone or in combination of two or more. The blending amount of the fragrance is usually 0.01 to 2% of the entire composition.

[0030] Preservatives: Examples include paraoxybenzoic acid esters and sodium benzoate. Colorants: These include Blue No. 1, Blue No. 2, Green No. 3, Yellow No. 4, Yellow No. 5, Red No. 106, Red No. 227, Caramel, Titanium Oxide, and Titanium Mica.

[0031] Optional Active Ingredients: Examples of suitable antibacterial agents include fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, sodium pyrrolidone carboxylate, tranexamic acid, epsilon-aminocaproic acid, allantoin, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, isopropylmethylphenol, copper gluconate, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, pyrophosphate, polyphosphate, metaphosphate, zeolite, aluminum lactate, potassium nitrate, calcium glycerophosphate, and Phellodendron Bark extract. EXAMPLES

[0032] The present invention will be specifically described below with reference to examples, comparative examples, and formulation examples, but the present invention is not limited to the following examples. In the following examples, % indicates % by mass unless otherwise specified.

[0033] [Examples and Comparative Examples] Dentifrice compositions (toothpastes) having the compositions shown in Tables 1 to 4 were prepared by conventional methods and evaluated by the following methods. The results are also shown in the tables. In addition, all of the dentifrice compositions of the examples containing (A) dextranase had the plaque removing effect and plaque formation inhibiting effect derived from the component (A).

[0034] (1) Evaluation method for perceived effectiveness (refreshing feeling in the mouth) A sensory evaluation was conducted using 10 expert panelists as subjects. The dentifrice composition packed in a laminated tube was squeezed out 1 cm onto a toothbrush, and the subjects brushed their teeth for 3 minutes in the usual way, rinsed their mouth with water, and evaluated the freshness of the mouth immediately after use and 10 minutes after use according to the following criteria. Here, the fresh feeling in the oral cavity refers to a distinctive sensation in which the feeling that the oral cavity has been cleaned is sustained even after the passage of time from immediately after use, and is felt prominently. Judgment criteria 5 points: Very strong feeling of freshness immediately after use and even after 10 minutes 4 points: A strong feeling of freshness immediately after use and even after 10 minutes have passed 3 points: Feels refreshing immediately after use and even after 10 minutes 2 points: A slight refreshing feeling immediately after use and even after 10 minutes 1 point: No refreshing feeling immediately after use or after 10 minutes The average of the results of the 10 judges was calculated and rated according to the following criteria. Those that secured the ratings of ◯, ◎, and ☆ were judged to be dentifrice compositions that provided an excellent feeling of freshness in the oral cavity and had a high sense of the effect of (A) inhibiting plaque formation by dextranase. Evaluation criteria ☆: Average score 4.5 points or more ◎: Average score 4.0 or more and less than 4.5 points ○: Average score 3.0 points or more and less than 4.0 points △: Average score 2.0 to less than 3.0 ×: Average score 1.0 or more and less than 2.0 points

[0035] (2) Method for evaluating the unpleasant taste after use A sensory evaluation was conducted using 10 expert panelists as subjects. The toothpaste composition filled in a laminated tube was squeezed out 1 cm onto a toothbrush, and the subjects brushed their teeth for 3 minutes in the same way as they normally would. After 10 minutes of use, the unpleasant taste (or lack of unpleasant taste) remaining in the mouth was judged according to the following criteria. Judgment criteria 4 points: Not unpleasant at all 3 points: Slightly unpleasant 2 points: I feel annoyed 1 point: Very strong feeling of dislike The average of the results of the 10 judges was calculated and rated according to the following criteria. Those that secured the ratings of ⊚ and ◯ were judged to be dentifrice compositions that did not leave an unpleasant aftertaste after use and had a good taste. Evaluation criteria ◎: Average score of 4 points or more ○: Average score 3.0 or more and less than 4 points △: Average score 2.0 to less than 3.0 ×: Average score 1.0 or more and less than 2.0 points

[0036] Details of the raw materials used are shown below. (A) Dextranase (13,000 units / g); manufactured by Daiichi Sankyo Propharma Co., Ltd. (B) Tin chloride: Fujifilm Wako Pure Chemical Industries, Ltd., tin(II) chloride dihydrate (B) Tin fluoride; Fujifilm Wako Pure Chemical Industries, Ltd., Tin(II) fluoride (C) Cationic cellulose; Nouryon Japan Co., Ltd., CELQUAT L-200 (C) Sodium tetradecene sulfonate; Lion Specialty Chemicals K-Lipolan PJ-400CJ, manufactured by K. (D) N-(4-cyanomethylphenyl)-p-menthanecarboxamide; Givaudan Japan Co., Ltd., Evercool 180 (D) N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide); Givaudan Japan Co., Ltd., Evercool 190 The detailed composition of fragrance A is described below.

[0037] [Table 1] Note: (B) / (C1) is the mass ratio of (the amount of component (B) as tin ion) / (the amount of component (C1)), and (B) / (C2) is the mass ratio of (the amount of component (B) as tin ion) / (the amount of component (C2)) (the same applies below).

[0038] [Table 2]

[0039] [Table 3]

[0040] [Table 4]

[0041] Composition of fragrance A: Peppermint oil 50 Peppermint refined oil (20% pre-distillate cut) 5 Peppermint refined oil (15% front and rear part cut) 5 Spearmint oil 1 Spearmint refined oil (20% pre-distillate cut) 1 Japanese peppermint oil 1 Japanese peppermint refined oil (30% front distillate cut) 1 Menthol 10 Carbone 1 1,8-Cineole 1 Anethole 5 Cinnamic aldehyde 1 Eugenol 1 Methyl Salicylate 1 Flavor 1 (Table 5) 1 Flavor 2 (Table 6) 1 Flavor 3 (Table 7) 1 Flavor 4 (Table 8) 1 Flavor 5 (Table 9) 1 Flavor 6 (Table 10) 1 Flavor 7 (Table 11) 1 Solvent (Table 12) Remaining Total 100%

[0042] [Table 5]

[0043] [Table 6]

[0044] [Table 7]

[0045] [Table 8]

[0046] [Table 9]

[0047] [Table 10]

[0048] [Table 11]

[0049] [Table 12]

[0050] An example of a prescription is shown below.

[0051] [Prescription Example 1] Dentifrice (A) Dextranase (13,000 units / g) 0.15 (B) Tin fluoride (stannous fluoride) 0.4 (C) Sodium tetradecene sulfonate 1 (C) Cationic cellulose 0.05 Sodium monofluorophosphate 0.38 Tranexamic acid 0.05 Tocopherol acetate 0.1 Isopropyl methylphenol 0.05 Aluminum Lactate 2 Potassium nitrate 5 Sodium citrate 0.5 Sodium hexametaphosphate 1 Abrasive Silica 18 Sodium methyl lauroyl taurate 0.6 Polyoxyethylene (20) hydrogenated castor oil 1 Sodium lauroyl glutamate 0.1 70% Sorbitol Solution 30 Propylene glycol 3 Xanthan gum 0.3 Sodium carboxymethylcellulose 1.0 Polyethylene glycol 4000 0.5 Copper gluconate 0.1 Viscosifying Silica 1 Titanium dioxide 0.4 Sodium saccharin 0.08 Sodium hydroxide (adjust pH to 5.7) Fragrance A 1.3 Purified water Balance Total 100%

[0052] [Prescription Example 2] Dentifrice (A) Dextranase (13,000 units / g) 0.15 (B) Tin fluoride (stannous fluoride) 0.4 (C) Sodium tetradecene sulfonate 1 (C) Cationic cellulose 0.05 Sodium fluoride 0.11 Epsilon Aminocaproic Acid 0.05 Tocopherol acetate 0.1 Isopropyl methylphenol 0.05 Aluminum Lactate 2 Potassium nitrate 5 Sodium citrate 0.5 Sodium hexametaphosphate 1 Abrasive Silica 15 Sodium lauryl sulfate 0.6 Sodium Lauroyl Sarcosinate 0.2 Coconut oil fatty acid amidopropyl betaine solution (30%) 0.9 85% glycerin solution 28 Propylene glycol 3 Carrageenan 0.3 Xanthan gum 0.3 Sodium carboxymethylcellulose 0.7 Sodium pyrrolidone carboxylate 3.0 Viscosifying Silica 2 Titanium dioxide 0.3 Sodium saccharin 0.1 Sodium hydroxide (adjust pH to 6.1) Fragrance A 1.3 Purified water Balance Total 100%

[0053] [Prescription Example 3] Mouthwash (A) Dextranase (13,000 units / g) 0.15 (B) Tin fluoride (stannous fluoride) 0.1 (C) Sodium tetradecene sulfonate 0.4 (C) Cationic cellulose 0.05 Tranexamic acid 0.05 Tocopherol acetate 0.1 Isopropyl methylphenol 0.05 70% sorbitol solution 5 85% glycerin solution 1 Xylitol 1 Sodium Lauroyl Sarcosinate 0.1 Propylene glycol alginate 0.1 Polyoxyethylene (60) hydrogenated castor oil 0.3 Polyoxyethylene (15) Cetyl Ether 0.1 Propylene glycol 3 Ethanol 10 Citric acid 0.05 Sodium citrate 0.3 Sodium hydroxide (adjust pH to 6.0) Fragrance A 0.1 Purified water Balance Total 100%

[0054] [Formulation Example 4] Mouth spray (A) Dextranase (13,000 units / g) 0.15 (B) Tin fluoride (stannous fluoride) 0.1 (C) Sodium tetradecene sulfonate 0.4 (C) Cationic cellulose 0.05 Tranexamic acid 0.05 Tocopherol acetate 0.1 Isopropyl methylphenol 0.05 Sodium hexametaphosphate 0.01 85% glycerin solution 30 70% sorbitol solution 4 Polyethylene glycol 400 2 Xylitol 1 Cetylpyridinium chloride 0.05 Ethanol 25 Polyoxyethylene (60) hydrogenated castor oil 2 Copper gluconate 0.01 Citric acid 0.05 Sodium citrate 0.3 Sodium hydroxide (adjust pH to 6.0) Fragrance A 0.5 Purified water Balance Total 100%

Claims

1. (A) dextranase, (B) Water-soluble tin salt and (C) One or more selected from cationized cellulose (C1) and α-olefin sulfonate (C2) An oral composition comprising:

2. 2. The oral composition according to claim 1, wherein the water-soluble tin salt (B) is at least one selected from the group consisting of tin chloride and tin fluoride.

3. 3. The oral composition according to claim 1 or 2, wherein the cationic cellulose (C1) is one or more selected from the group consisting of hydroxyethyl cellulose dimethyl diallyl ammonium chloride and O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethyl cellulose chloride.

4. The oral composition according to any one of claims 1 to 3, wherein the α-olefin sulfonate (C2) is sodium α-olefin sulfonate having 14 to 16 carbon atoms.

5. 5. The oral composition according to claim 1, wherein when the oral composition contains cationized cellulose (C1) as component (C), the mass ratio of (B) (the amount of tin ions in component (B)) / (C1) is 0.3 to 30, and when the oral composition contains α-olefin sulfonate (C2), the mass ratio of (B) (the amount of tin ions in component (B)) / (C2) is 0.02 to 5.

6. The oral composition according to any one of claims 1 to 5, wherein, when the oral composition contains a cationic cellulose (C1) as component (C), the content thereof is 0.02 to 0.2 mass%, and when the oral composition contains an α-olefin sulfonate (C2), the content thereof is 0.1 to 3 mass%.

7. 7. The oral composition according to claim 1, wherein the content of component (A) is 0.0077 to 1.54 mass%, and the content of component (B) is 0.02 to 1 mass% in terms of tin ions.

8. The oral composition according to any one of claims 1 to 7, further comprising (D) one or more selected from the group consisting of N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate and menthyl succinate.

9. The oral composition according to claim 8, wherein the content of component (D) is 0.00001 to 0.1 mass %.

10. The oral composition according to any one of claims 1 to 9, which is a dentifrice, a mouthwash or a mouth spray.

Images