Improvements in or relating to organic compounds

Abstract

Methods for assessing the impact of test fragrance compositions on the well-being of human subjects, as well as methods for preparing or optimizing fragrance compositions for enhancing the well-being of human subjects, fragrance compositions that enhance well-being, and consumer products containing the same, are provided.

Description

[Technical field]

[0001] FIELD OF THEINVENTION The present invention relates to methods for measuring the effect of a fragrance composition on the well-being of a human subject, to methods for preparing or optimizing fragrance compositions that enhance well-being, to fragrance compositions that enhance well-being, and to consumer products containing fragrance compositions. [Background technology]

[0002] 2. Background of the Invention Well-being (or, more precisely, "subjective well-being") is a complex concept that people generally do not easily explain. Most people would simply equate well-being with a feeling of happiness or perhaps calm. A more precise definition of well-being that is sometimes used in the academic literature refers to well-being as a person's affective and cognitive evaluation of his or her life. In this definition, the so-called "affective" component refers to a person's moods and emotions. Positive emotions occur when the experienced moods and emotions are pleasant (e.g., joy, elation, love, etc.), whereas emotions are considered negative when the experienced moods and emotions are unpleasant (e.g., guilt, anger, shame, etc.). Psychologically, a person experiences a mood of happiness when the affective balance is such that the positive emotions outweigh the negative emotions. Another important component of subjective well-being (the so-called "cognitive" component) refers to a person's assessment of his or her life satisfaction, both in broad terms (e.g., life as a whole) and in narrower terms, such as a sense of satisfaction with relationships, life planning (the control one has over one's life), a sense of purpose, and the like.

[0003] Well-being is often measured using self-report methods, typically in the form of a questionnaire. Respondents are asked a series of questions, each of which relates to a metric that is related to a different subjective state that is believed to have an effect on the affective or cognitive components of well-being. This may include subjective states that have a positive or negative effect on subjective well-being, e.g. sadness, fatigue, patience, irritability, etc. For each question of the type "Are you sad?", for example, the respondent is asked to rate the relevance of each subjective state on a rating scale between extremes, e.g., not very applicable to very applicable. By subjecting the respondent's response data to statistical analysis, it is possible to quantify well-being. Thus, many indices have been developed to measure well-being and related concepts. However, knowing which questions to ask can significantly affect the reliability of such measurement techniques.

[0004] Reliable means of measuring or assessing subjective well-being have been highly desirable since the latter half of the twentieth century due to the economic, political and sociological importance attached to well-being parameters. More recently, well-being has also assumed increasing importance as a design parameter in the development and commercialization of consumer products, such as laundry care, household care and personal care products. Manufacturers of these products have recognized that modern consumers seek emotional experiences from the products they purchase, and that they are particularly interested in brands with which they feel a personal connection and that offer them a sense of health and well-being. Fragrances are widely employed by consumer product companies to impart a pleasant and highly-liked odor to their products, which drives consumer preferences and thus influences purchasing decisions.

[0005] However, in an increasingly competitive marketplace, mere taste is often not enough to differentiate one brand from its competitors. Consequently, in marketing their products, consumer product companies frequently refer to a wide range of product benefits, which are typically communicated through various advertising campaigns, as well as on their product packaging and labeling, which together form an important part of their branding strategies. New differentiating benefits are constantly being sought, and fragrances have often been employed as a means to achieve those benefits. For example, fragrances have been employed to create real or perceived functional benefits, which may be related to cosmetic benefits, hygiene benefits, odor-relieving benefits, etc.

[0006] In addition to their functional effects, odors are known to elicit emotional responses in human subjects. The temporarily beneficial psychological effects of odors on human emotions have been widely studied in the academic literature. For example, the effect of odors on the affective (i.e. emotional) experience of human subjects has been studied by C. Chrea et al. (2009), “Mapping the semantic space for the subjective experience of emotional responses to odours”, Chemical Senses, 34 (2009) 49-62 and S. Delplanque et al. “How to map the affective semantic space of Scents”, Cognition & Emotion 26(5) (2012) 885-898. Among other things, these papers describe linguistic measurement methods in the form of questionnaires, where the measurement period is selected so as to be able to differentiate between the various moods and emotions induced by odors emanating from scented and flavored products. However, in these papers, the cognitive aspects of well-being are underestimated and are limited to memory aspects related to olfactory function.

[0007] The patent literature also describes fragrance compositions for consumer products that are specifically designed to create a pleasant mood state (see, for example, 2008 / 050086 A1) and sleep quality (see, for example, WO 2016 / 146673 A1). However, all of these prior art documents only touch upon individual emotional aspects of well-being (e.g., happiness or sleep quality) without actually addressing both the affective and cognitive aspects of well-being as a comprehensive concept. Thus, there remains a need to provide methods for measuring the effect of fragrance compositions on the subjective well-being of human subjects, as well as methods for preparing or optimizing fragrance compositions that enhance the well-being of human subjects. Summary of the Invention

[0008] Summary of the Invention In a first aspect, the present invention provides a method for assessing the impact of a test fragrance composition on the well-being of a human subject, the method comprising the steps of: a) having one or more human subject(s) assess their well-being in the absence of the test fragrance composition by scoring a number of well-being attributes; i) where the well-being attributes include "not anxious", "not sad", "not busy", "not irritated", "not stressed", "happy", "optimistic", "excited", "fulfilled", "motivated", "energetic", "curious", "not bored", "not tired", "mentally alert", "calm", "complacent", and "perseverant"; and ii) where each well-being attribute has a weight;

[0009] b) calculating a baseline well-being score in the absence of the test fragrance composition by multiplying the score of each well-being attribute by its corresponding weight and taking the products and summing these products for all well-being attributes; c) repeating steps a) and b) in the presence of the test fragrance composition to determine a well-being score with the test fragrance composition; and d) determining the effect of the test flavouring composition on well-being by subtracting the baseline well-being score from the well-being score with the test flavouring composition; The method includes:

[0010] In a second aspect, the present invention provides a method for preparing or optimizing a fragrance composition for enhancing the well-being of a human subject, the method comprising the steps of: a-d) assessing the impact of one or more fragrance composition(s) on the well-being of a human subject according to the methods described above; and e) selecting fragrance compositions with a positive impact on well-being; The method includes:

[0011] In a third aspect, the present invention provides a perfume composition prepared or optimized according to the method defined above, comprising perfume ingredients from at least three groups, each group having a different odour attribute, wherein the odour attributes of the groups are selected from the group consisting of "Citrus-Mandarin", "Citrus-Orange", "Floral-Orange Flower", "Animal-Dung", "Floral-Medicinal", "Fruity-Candied Fruit", "Spicy-Cinnamon", "Sweet-Tonka", "Citrus-Lime" and "Spicy-Clove"; preferably from the group consisting of "Citrus-Mandarin", "Citrus-Orange", "Floral-Orange Flower", "Animal-Dung", "Floral-Medicinal" and "Fruity-Candied Fruit".

[0012] In a fourth aspect, there is provided a consumer product comprising the perfume composition of the present invention and a suitable base. In a fifth aspect, the present invention provides the use of a fragrance composition according to the invention for enhancing the well-being of a human subject.

[0013] Detailed Description of the Invention In addressing the shortcomings of the prior art, the Applicant has carried out extensive research into the relationship between fragrance compositions and the well-being of human subjects employing experimental psychological measurements, consumer testing, and statistical analysis. More specifically, the applicant provides a means to reliably assess the impact of fragrance compositions on well-being using a questionnaire that breaks down the concept of well-being into key attributes that have an effect on the emotional or cognitive components of well-being. The key attributes are weighted in a manner that reflects the relative importance of each attribute to the overall concept of well-being. The method of the present invention is particularly sensitive and can detect hard-to-detect perceptions of perfume performance with respect to well-being that may otherwise be hidden under the noise of liking or perfume intensity if the perfumes are tested using standard consumer testing techniques. Thus, the method of the present invention offers the perfume composition creator a useful creative tool, allowing them to reduce the number of design iterations required to arrive at a desired perfume composition.

[0014] The well-being metric was defined by applying unsupervised clustering of experimental psychology and linguistic attributes of well-being to identify the most relevant dimensions for assessing well-being. The well-being attributes take into account different aspects of well-being, such as affective, happiness-related, social, and physical aspects. These aspects may have both affective (emotional) and cognitive (rational) components.

[0015] Typical linguistic well-being attributes include, for example, "active", "adventurous", "angry", "anxious", "ashamed", "bored", "calm", "attentional", "clear", "comfortable", "confident", "content", "daring", "depressed", "unhappy", "energetic", "enthusiastic", "excited", "afraid", "irritated", "happy", "healthy", "impulsive", "in control of one's situation", "uneasy", "curious", "irritated", "isolated", "delighted", "lonely", "loved", "mentally alert", "motivated", "nervous", "optimistic", "patient", "calm", "rested", "busy", "sad", "safe", "fulfilled", "self-aware", "self-respecting", "social in a social environment", "stressed", "supported", "surprised", "threatened", "tired", "anxious", "vulnerable", "well-being", "worthy" or "concerned".

[0016] In the course of the study, 18 linguistic attributes were found to be particularly responsive to changes in well-being perceptions associated with the appearance of fragrance compositions and associated with changes in fragrance quality. These attributes are therefore particularly relevant for investigating how fragrances may affect the well-being of human subjects. These attributes are: "not anxious," "not bored," "calm," "excited," "not tired," "not irritated," "happy," "curious," "energetic," "mentally alert," "motivated," "optimistic," "perseverant," "calm," "not busy," "not sad," "fulfilled," and "not stressed." These 18 well-being attributes are hereafter referred to as the WB-18 attributes.

[0017] Surprisingly, well-being attributes related to social aspects such as "ashamed", "isolated", "lonely", "loved", "sociable in social environments", "supported" and "worthiness" were found to be irrelevant or inapplicable in the context of fragrance compositions. Hence, the WB-18 attributes primarily consider both the affective (emotional) and cognitive (rational) aspects of an individual.

[0018] The weighting of the well-being attributes is determined as follows: a) administering to one or more human subjects a well-being score (wb) for each of the WB-18 attributes; i having participants assess their well-being in the absence of the test fragrance composition by providing b) applying a factor analysis, in particular a principal component analysis, to the well-being scores obtained in step a) in order to determine the influence of each well-being attribute on the overall well-being, resulting in M ​​well-being factors F j To bring about;

[0019] i) where F is the well-being factor j Each of the factors is a variance v expressed as a percentage of the sum of the variances of all well-being factors. j having; ii) where F is the well-being factor j Each of j Loadings l expressed as a percentage of the sum of the loadings j A finite number of well-being attributes, n j Contains; and iii) wherein none of the well-being attributes appears in more than one well-being factor; and c) Equation 1

number

[0020] Principal component analysis revealed the following: - The well-being attributes "not anxious", "not sad", "not busy", "not irritable", and "not stressed" are associated with the first well-being factor F1 with variance v1; - The well-being attributes “happy”, “optimistic”, “excited”, “fulfilled”, variance v1 “motivated”, “energetic” are related to a second well-being factor F2 with variance v2; - The well-being attributes "interesting" and "not boring" are associated with the third well-being factor F3 with variance v3; - The well-being attributes "not tired" and "mentally alert" are associated with the fourth well-being factor F4 with variance v4; - The well-being attributes “calm”, “complacent”, and “patient” are associated with the fifth well-being factor F5 with variance v5;

[0021] - The variance v1 is 48% of the sum of the variance of all well-being factors; - The variance v2 is 24% of the sum of the variance of all well-being factors; - variance v3 is 12% of the sum of the variance of all well-being factors; - variance v4 is 9% of the sum of the variance of all well-being factors; - variance v5 is 7% of the sum of the variance of all well-being factors;

[0022] In addition, the following was found: - on the first well-being factor F1, the loading of the well-being attribute "not anxious" is 22.2%, the loading of the well-being attribute "not sad" is 21.5%, the loading of the well-being attribute "not busy" is 20.5%, the loading of the well-being attribute "not irritated" is 20.1%, and the loading of the well-being attribute "not stressed" is 15.7%; - on the second well-being factor F2, the loading of the well-being attribute "happy" is 19.6%, the loading of the well-being attribute "optimistic" is 19.2%, the loading of the well-being attribute "excited" is 17.2%, the loading of the well-being attribute "satisfied" is 16.3%, the loading of the well-being attribute "motivated" is 13.9%, and the loading of the well-being attribute "energetic" is 13.8%;

[0023] - on the third well-being factor F3, the loading of the well-being attribute "curious" is 51.0% and the loading of the well-being attribute "not boring" is 49.0%; - in the fourth well-being factor F4, the loading of the well-being attribute "not tired" is 51.0% and the loading of the well-being attribute "mentally alert" is 49.0%; and - On the fifth well-being factor F5, the loading of the well-being attribute “calm” is 38.0%, the loading of the well-being attribute “comfortable” is 32.0%, and the loading of the well-being attribute “patient” is 30.0%.

[0024] Thus, in an embodiment of the invention, each well-being attribute has a weight according to the following table: [Table 1]

[0025] Preferably, the fragrance compositions that are not preferred by the panelists are excluded from the list of tested fragrance compositions to be evaluated, since these fragrance compositions are unlikely to generate a positive evaluation for well-being. The degree of liking of the remaining test fragrance compositions may still vary according to a predefined scale. For example, vocabulary such as "I like this fragrance a little", "this fragrance is nice", "I love this fragrance" etc. may be used to define the preference. Preferably, the strength of the preference may be represented by moving a slider button across a continuous range of preferences, for example 1 (I dislike it extremely) to 9 (I like it extremely). The slider may be a physical device or virtual, for example on a digital touch screen.

[0026] Similarly, the slider may be advantageously used to score the well-being attributes described herein above. In this case, the continuous scale on which the slider movement is based preferably ranges from very negative to very positive scores. Preferably, bias induced by variable perfume composition intensity is eliminated by diluting strong perfume compositions so that all test perfume compositions have roughly the same intensity or strength. Thus, in an embodiment of the present invention, even though care has been taken to equalize the intensity of the test fragrance compositions, the intensity of the test fragrance compositions is also evaluated by a human subject(s).

[0027] By carrying out well-being evaluation on multiple highly preferred fragrance compositions at the same intensity, it is surprisingly found that the variance of the impact on well-being is not correlated with the variance of fragrance preference, nor with the variance of fragrance intensity as perceived by individual human subjects.This is shown in Example 3.Therefore, the positive impact on well-being is independent of the preference of fragrance composition.This is a conclusive result, which could not be predicted by those skilled in the art.The immediate benefit of this is that it allows consumer research to reveal hidden functions that would otherwise be overlooked.

[0028] In an embodiment, the method of the present invention comprises the steps of: f) to compare the perfume ingredients present in those perfume compositions that have a positive impact on well-being; g) identifying odor attributes common to those fragrance compositions; and h) creating new perfume compositions with an increased proportion of perfume ingredients with the odor attributes identified in step g); Further includes:

[0029] Perfume compositions and individual perfume ingredients may be characterized by their odor attributes. Although perfume creation is part science and part art and there are no absolute prescribed definitions for the odor attributes of perfume compositions and perfume ingredients, a skilled perfumer will nevertheless be able to assign perfume compositions and ingredients to general odor descriptors and odor families, recognizing that there will be some room for subjectivity.

[0030] Odor families provide a description of an odour space and their number is often limited. Thus, most of the ingredients used in perfumery and that are specifically useful in the context of the present invention may be described by a small set of odour families selected from the group consisting of "aldehyde", "amber", "animal", "aromatic / herbal", "citrus", "floral", "fruity", "green", "musk", "spicy", "sweet", "watery" and "woody".

[0031] Odor descriptors provide a more precise description of the odor of a perfume composition or ingredient within a family. They are more abundant and their number and variety are often limitless. In the context of the present invention, the number of odor descriptors is as follows: "aldehydic", "almond", "amber dry", "ambergris", "anistalagon", "apple", "armoise", "balsam", "banana", "blackcurrant", "butter", "candied fruit", "caraway seed", "cedar", "cinnamon", "citronella", "clove", "cocoa", "coconut", "conifer", "cooked sugar", "copaiba", "coriander leaf", "cucumber", "eucalyptus", "dung", "freesia", "galbanum", "grapefruit", "grass", "heliotrope", "jasmine", "lavender", "leaf", "peel", "lemon", "licorice-fenugreek", "lily of the valley", "lemon ... The list is limited to a minimal number of linguistic items consisting of: "lime", "liquor", "lychee", "mandarin", "mango", "medicinal", "melon", "metallic", "milk cream", "molasses", "moss", "mushroom", "musk", "musk tonkin", "nut", "orange", "orange flower", "oris", "passion fruit", "patchouli", "peach", "pear", "peppermint", "pineapple", "raspberry", "rhubarb", "rose", "rosemary", "sandalwood", "seawater", "solar", "strawberry", "terpenic", "thyme", "tonka", "vanilla", "vetiver", "violet", and "wax".

[0032] This selection of odor families and odor descriptors allows the skilled perfumer to characterize the odors of all the perfume ingredients contained in the perfumer's palette. Nevertheless, for the skilled perfumer reading the contents of this entire specification together with their common sense, modifying some or all of this vocabulary, where subjectivity exists, will not create an undue burden and such modifications will not affect the selection of perfume ingredients useful for positively influencing the perception of well-being.

[0033] The set of odor families and descriptors may be absorbed into the dimensions of a multi-dimensional odor space. The overall odor of a perfume composition may be expressed as a weighted sum of the odor attribute contributions of the individual perfume ingredients contained in the perfume composition. Due to the high dimensionality of odors, it may be convenient to reduce this high dimensionality by applying statistical methods such as principal component analysis, multiple-scaling, or self-organized maps. Preferably, principal component analysis (PCA) is used. The Applicant has now discovered that certain odour attributes affect well-being more positively than others and that a classification of perfume ingredients is possible according to their position in the odour space and their impact on the perception of well-being.

[0034] In particular, it was found that perfume compositions with odor attributes such as "citrus-mandarin", "citrus-orange", "floral-orange flower", "fruity-candied fruit", "floral-medicinal" and "animal-dung" have a highly positive impact on well-being, while perfumes with odor attributes such as "spicy-cinnamon", "sweet-tonka", "citrus-lime" and "spicy-clove" perform poorly. These results may also be considered surprising to those skilled in the art, especially evaluators and perfumers, who would not have expected that odor attributes such as "floral-medicinal" and "animal-dung" would have a more positive evaluation on well-being than "spice-cinnamon" or "citrus-lime".

[0035] Thus, in one embodiment of the invention, the proportion of one or more perfume ingredient(s) having an odor attribute selected from the group consisting of "Citrus-Mandarin", "Citrus-Orange", "Floral-Orange Flower", "Animal-Dung", "Floral-Medicinal", "Fruity-Candied Fruit", "Spicy-Cinnamon", "Sweet-Tonka", "Citrus-Lime" and "Spicy-Clove"; more preferably the proportion of one or more perfume ingredient(s) having an odor attribute selected from the group consisting of "Citrus-Mandarin", "Citrus-Orange", "Floral-Orange Flower", "Animal-Dung", "Floral-Medicinal" and "Fruity-Candied Fruit" is increased in step h).

[0036] Thus, the present invention teaches the skilled perfumer how to formulate perfume compositions in such a way that they are likely to quickly arrive at a perfume composition that will induce or be associated with increased well-being. The effects are sufficiently pronounced that they can be reliably and reproducibly measured. Perfume compositions made according to the teachings disclosed herein can be hedonically pleasant, suitable for a wide range of consumer products, and of sufficient comfort / acceptance that they would be appropriate even if they did not possess the added functionality.

[0037] The method of the present invention comprises the steps of: - promoting a reduction in negativity, i.e., the level of worry, sadness, restlessness, irritability, and / or stress that the subject reports feeling; and / or - promoting an increase in positivity, i.e., the degree to which the subject reports feeling happiness, optimism, excitement, satisfaction, motivation, and / or energy; and / or - promoting an increase in interest, i.e., more interest and / or less boredom that the subject reports feeling; and / or

[0038] - promoting a reduction in fatigue, i.e., less fatigue that the subject reports feeling, and / or a greater degree of mental alertness; and / or - promoting an increase in serenity, i.e., the degree of calm, composure, and / or patience that the subject reports feeling; It has been found that this method allows for the preparation or optimization of fragrance compositions that enhance the well-being of a human subject.

[0039] The present invention also provides a fragrance composition comprising well-being enhancing fragrance ingredients selected by the methods described herein. In particular, the present invention provides the skilled perfumer with the following: i) to compare fragrance ingredients contained in fragrance compositions that have been found to have a positive impact on well-being in human subjects; ii) to identify common odor attributes of these fragrance ingredients; and iii) presenting new fragrance compositions containing increased amounts of ingredients having the odor attributes identified in step b); This makes it possible.

[0040] The present invention provides a fragrance composition for enhancing well-being, comprising fragrance ingredients from at least three groups, each group having a different odor attribute, wherein the odor attributes of the groups are selected from the group consisting of "Citrus-Mandarin", "Citrus-Orange", "Floral-Orange Flower", "Animal-Dung", "Floral-Medicinal", "Fruity-Candied Fruit", "Spicy-Cinnamon", "Sweet-Tonka", "Citrus-Lime", and "Spicy-Clove"; more preferably, from the group consisting of "Citrus-Mandarin", "Citrus-Orange", "Floral-Orange Flower", "Animal-Dung", "Floral-Medicinal", and "Fruity-Candied Fruit".

[0041] In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having a "citrus-orange" odor attribute in a concentration of 0.1 to 25% by weight, more specifically 0.2 to 15% by weight, and even more specifically 0.25 to 10% by weight. In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having a "citrus-lime" odor attribute in a concentration of from 0.05 to 5% by weight, more specifically from 0.1 to 3% by weight, and even more specifically from 0.12 to 1.5% by weight. In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having a "Citrus-Mandarin" odor attribute in a concentration of 0.05 to 5% by weight, more specifically 0.1 to 3% by weight, and even more specifically 0.12 to 1.5% by weight.

[0042] In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having the odor attribute of "sweet tonka" in a concentration of from 0.05 to 1% by weight, more specifically from 0.07 to 0.9% by weight, and even more specifically from 0.1 to 0.75% by weight. In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having a "fruity-candied fruit" odor attribute in a concentration of 0.01 to 1 wt.-%, more particularly 0.02 to 0.9 wt.-%, and even more particularly 0.03 to 0.65 wt.-%. In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having a "floral-orange flower" odor attribute in a concentration of 0.01 to 1 wt.-%, more specifically 0.025 to 0.75 wt.-%, and even more specifically 0.03 to 0.5 wt.-%.

[0043] In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having the odor attribute of "Floral-Orange Medicinal" in a concentration of 0.01 to 1.0% by weight, more specifically 0.02 to 1.0% by weight, and even more specifically 0.035 to 0.5% by weight. In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having a "spicy-clove" odor attribute in a concentration of 0.005 to 0.7% by weight, more specifically 0.01 to 0.5% by weight, and even more specifically 0.02 to 0.25% by weight. In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having an "animal-feces" odor attribute in a concentration of 0.005-0.07% by weight, more specifically 0.07-0.05% by weight, and even more specifically 0.01-0.030% by weight.

[0044] In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having the odor attribute of "spicy cinnamon" in a concentration of 0.0001 to 0.05% by weight, more specifically 0.001 to 0.025% by weight, and even more specifically 0.005 to 0.01% by weight. Throughout this application, weight percentages, % by weight, are based on the total weight of perfume ingredients present in the perfume composition, unless otherwise indicated. Preferably, each of the above groups, if present at all, is present in the concentrations indicated above.

[0045] In an embodiment of the present invention, the fragrance composition comprises an orange oil, such as orange brazil crude oil, grapefruit oil, orange oil, orange bitter oil, orange brood oil, etc. S and ORANGE RECONSTITUTIONS; comprising one or more fragrance ingredients having "citrus-orange" odor attributes selected from the group consisting of ORANGE OIL COLORLESS, ORANGE OIL CONCENTRATED, ORANGE ESSENCE, ORANGE TERPENE, BIGARADE PHASE OIL, TANJELO OIL, natural orange carbonyl and aldehyde, and mixtures thereof.

[0046] In an embodiment of the invention, the fragrance composition is selected from the group consisting of CYMENE PARA (4-methyl-1-isopropylbenzene), CEDRAT OIL, CITRATHAL R (1,1-diethoxy-3,7-dimethylocta-2,6-diene), DELTA-3-CARENE (3,7,7-trimethylbicyclo[4.1.0]hept-3-ene), DIPENTENE (1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene), ELEMI OIL, ELEMI RESINOID, LEMON GREEN PHASE OIL, KIME DIENES, LIME OIL DISTILLED, LIME OIL EXPRESSED, LIME OXIDE, LIME TERPENE RECONSTITUTION, OCIMENE ((E)-3,7-dimethylocta-1,3,6-triene), TERPINENE The composition comprises one or more fragrance ingredients having "citrus-lime" odor attributes selected from the group consisting of ALPHA (1-methyl-4-propan-2-ylcyclohexa-1,3-diene), TERPINENE GAMMA (1-methyl-4-propan-2-ylcyclohexa-1,4-diene), TERPINEOL (2-(4-methyl-3-cyclohexen-1-yl)-2-propanol) and TERPINOLENE (1-methyl-4-propan-2-ylidenecyclohexene), and mixtures thereof.

[0047] In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having "citrus-mandarin" odor attributes selected from the group consisting of CLEMENTINE OIL, DIMETHYL ANTHRANILATE (METHYL 2-METHYLAMINOBENZOATE), MANDARIN OIL, MANDARIN OIL COLORLESS, MANDARIN GREEN OIL, MANDARIN YELLOW OIL, MANDARIN PHASE OIL, TAMARINE OIL, TAMARINE RECONSTITUTIONS, TANGERINE OIL, TANGERINE RECONSTITUTION, TANGERINOL ((E)-6,10-dimethylundec-5,9-dien-2-yl acetate), and mixtures thereof.

[0048] In an embodiment of the present invention, the fragrance composition comprises BICYCLO NONALACTONE (3,4,4a,5,6,7,8,8a-octahydrochromen-2-one), COUMARIN (chromen-2-one), and TOLYL ALDEHYDE PARA (4-methylbenzaldehyde), COUMARIN RECONSTITUTION, FLOUVE OIL, FLOUVE RECONSTITUTION, HAY OIL, HAY ABSOLUTE, KOUMALACTONE (3,6-dimethyl-3a,4,5,6,7,7a-hexahydro-3H-benzofuran-2-one), MARSHALLOW ABSOLUTE, MATE ABSOLUTE, MATE RECONSTITUTION, METHYL OCTALACTONE (5-BUTYL-4-METHYLOXOLAN-2-ONE), TONKAROSE ((E)-DECA-9-EN-1-YL 3-(2-HYDROXYPHENYL)ACRYLATE), SESAME ROASTED ABSOLUTE, TOBACCO LEAF ABSOLUTE, TONKA ABSOLUTE, TONKA ABSOLUTE COLORLESS, TONKA BEAN OIL, ACETANISOLE (1-(4-METHOXYPHENYL)ETHANONE), ACETOPHENONE EXTRA (1-PHENYLETHANE), ANISIC ALDEHYDE (4-METHOXYBENZALDEHYDE), ANISYL ALCOHOL ((4-METHOXYPHENYL)METHANOL), AUBEPINE PARA CRESOL (4-METHOXYBENZALDEHYDE), DIMETHYL HYDROQUINONE CRYSTALS (1,4-DIMETHOXYBENZENE), HELIOTROPINE The composition comprises one or more fragrance ingredients having a "sweet tonka" odor attribute selected from the group consisting of CRYSTALS (benzo[d][1,3]dioxole-5-carbaldehyde), HYDRATROPIC ALDEHYDE (2-phenylpropanal), METHYL ACEOPHENONE (1-(p-tolyl)ethanone), MIMOSA ABSOLUTE, VERATRYL ALDEHYDE (3,4-dimethoxybenzaldehyde), and mixtures thereof.

[0049] In an embodiment of the invention, the fragrance composition comprises CRISTALON (ethyl 2,6,6-trimethylcyclohexa-1,3-diene-1-carboxylate), GIVESCONE (ethyl 2-ethyl-6,6-dimethylcyclohex-2-ene-1-carboxylate), DAMASCENONE ((E)-1-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)but-2-en-1-one), DAMASCONE ALPHA ((E)-1-(2,6,6-trimethyl-1-cyclohex-2-enyl)but-2-en-1-one), DAMASCONE BETA ((E)-1-(2,6,6-trimethyl-1-cyclohexenyl)but-2-en-1-one), DAMASCONE ETHER ... The fragrance composition comprises one or more fragrance ingredients having "fruity-candied fruit" odor attributes selected from the group consisting of DELTA (1-(2,6,6-trimethyl-1-cyclohex-3-enyl)but-2-en-1-one, more specifically (E)-1-(2,6,6-trimethyl-1-cyclohex-3-enyl)but-2-en-1-one), and POMAROSE ((2E,5Z)-5,6,7-trimethylocta-2,5-dien-4-one), and mixtures thereof.

[0050] In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having "floral-orange flower" odor attributes selected from the group consisting of ORANGE FLOWER RECONSTITUTIONS, METHYL ANTHRANILATE (methyl 2-aminobenzoate), ORANGER CRYSTALS (1-naphthalen-2-ylethanone), JASMIN SAMBAC OIL, and mixtures thereof.

[0051] In an embodiment of the present invention, the fragrance composition comprises one or more fragrance ingredients having "floral-medicinal" odor attributes selected from the group consisting of YARA YARA (2-methoxynaphthalene), CRESYL METHYL ETHER PARA (1-methoxy-4-methylbenzene), ETHYL BENZOATE, ETHYL SALICYLATE, METHYL BENZOATE, METHYL SALICYLATE, TEBERUSE FLOWER RECONSTITUTIONS, and mixtures thereof.

[0052] In an embodiment of the present invention, the fragrance composition comprises one or more fragrance ingredients having "spicy-clove" odor attributes selected from the group consisting of EUGENYL ACETATE ((2-methoxy-4-prop-2-enylphenyl) acetate), ACETYL ISOEUGENOL (2-methoxy-4-prop-1-en-2-ylphenol acetate), crude, colorless and rectified CLOVE LEAF OIL, DIHYDRO EUGENOL (2-methoxy-4-propylphenol), EUGENOL (2-methoxy-4-prop-2-enylphenol), and ISO EUGENOL (2-methoxy-4-prop-1-en-2-ylphenol), and mixtures thereof.

[0053] In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having "animal-feces" odor attributes selected from the group consisting of INDOLE and INDOLENE (8,8-bis(1H-indol-3-yl)-2,6-dimethyloctan-2-ol), INDOFLOR (4,4a,5,9b-tetrahydroindeno[1,2-d][1,3]dioxine), and mixtures thereof.

[0054] In an embodiment of the invention, the fragrance composition comprises one or more fragrance ingredients having a "spicy cinnamon" odor attribute selected from the group consisting of CINNAMIC ALDEHYDE (3-phenylprop-2-enal), CINNAMALVA ((E)-3-phenylprop-2-enenitrile), CINNAMON BARK OIL; METHYL CINNAMIC ALDEHYDE ((Z)-2-methyl-3-phenylacrylaldehyde), and mixtures thereof.

[0055] In an embodiment of the invention, the fragrance composition comprises CITRONELLOL (3,7-dimethyloct-6-en-1-ol), DECALACTONE GAMMA (5-hexyloxolan-2-one), GARDENOL (1-phenylethyl acetate), HEXENOL-3-CIS ((Z)-hex-3-en-1-ol), IONONE BETA (4-(2,6,6-trimethylcyclohexen-1-yl)but-3-en-2-one), LINALOOL (3,7-dimethylocta-1,6-dien-3-ol), LINALYL ACETATE (3,7-dimethylocta-1,6-dien-3-ol acetate) and PEACH at least 5, more particularly at least 6, perfume ingredients selected from the group consisting of CITRONELLOL (5-heptyloxolan-2-one), ETHYLENE BRASSYLATE (1,4-dioxacycloheptadecane-5,17-dione), BENZYL ACETATE, HEDIONE (methyl 3-oxo-2-pentylcyclopentane acetate), LINALLOL (3,7-dimethylocta-1,6-dien-3-ol), ISO E SUPER (1-(2,3,8,8-tetramethyl-1,3,4,5,6,7-hexahydronaphthalen-2-yl)ethanone), PHENYL ETHYL ALCOHOL, ETHYL and VANILLIN, and INDOLE in combination with at least five, more specifically at least six, perfume ingredients selected from the group consisting of VANILLIN, INDOLE, INDOLE-based perfume, and VANILLIN-based perfume.

[0056] In an embodiment of the invention, the fragrance composition comprises DAMASCENONE in combination with at least five, more specifically at least six, fragrance ingredients selected from the group consisting of CITRONELLOL (3,7-dimethyloct-6-en-1-ol), GARDENOL (1-phenylethyl acetate), HEXENYL-3-CIS ACETATE ((Z)-hex-3-en-1-ol), IONONE BETA ((4-(2,6,6-trimethylcyclohexen-1-yl)but-3-en-2-one), LINALOOL (3,7-dimethylocta-1,6-dien-3-ol), LINALYL ACETATE (3,7-dimethylocta-1,6-dien-3-ol acetate), and PEACH PURE (5-heptyloxolan-2-one).

[0057] In the context of the present invention, the term "perfume ingredient" refers to an ingredient whose function is to provide a noticeable and discernible odor to a perfume composition. Perfume ingredients include highly functional ingredients that are intended to provide a strong olfactory impression, as well as less functional ingredients that are intended to provide a weaker olfactory impression. Certain perfume ingredients referred to herein refer to reconstitutions, which are mixtures of perfume ingredients intended to mimic a particular odor, such as that of "blood orange" or "green apple".

[0058] Where common names are used herein to describe useful perfume ingredients, the skilled perfumer will understand that these are names commonly used in the art of perfumery.However, the skilled perfumer will also understand that these ingredients can also be known by other common synonyms, by CAS registry numbers, and by more formal nomenclature, such as IUPAC nomenclature.Furthermore, the skilled perfumer will be familiar with these other common synonyms, as well as more formal nomenclature, or at least familiar with standard references, such as the Good Scents Company website, which contains a comprehensive list of common names, registry numbers, and more formal nomenclature for perfume ingredients that are included in the perfumer's palette.

[0059] The fragrance composition of the present invention could consist entirely of the fragrance ingredients referred to herein above. However, in addition to the fragrance ingredients referred to herein above, the fragrance composition of the present invention may contain other fragrance ingredients. Exhaustive lists of other suitable fragrance ingredients may be found in fragrance literature, such as "Perfume & Flavor Chemicals", S. Arctander (Allured Publishing, 1994), as well as later editions of this literature, the fragrance ingredients contained therein being incorporated herein by reference.

[0060] The perfume composition of the present invention may further contain substantially odorless ingredients. In the context of the present invention, "substantially odorless" means that the ingredient does not have an odor or that its odor is weak and often barely perceptible. These substantially odorless ingredients include excipients conventionally used in perfume compositions together with perfume ingredients, such as carrier materials, and other auxiliaries commonly used in the art, such as solvents, such as dipropylene glycol (DPG), isopropyl myristate (IPM), benzyl benzoate (BB), propylene glycol (PG) and triethyl citrate (TEC); mineral oils and vegetable oils; and antioxidants. Therefore, these substantially odorless ingredients are not considered perfume ingredients in the context of the present invention. In particular, solvents are not taken into account when calculating the weight percentage.

[0061] The perfume compositions of the present invention may be presented in oil-free form or they may be encapsulated.Several encapsulation media are known in the art for encapsulating perfume compositions.Specific encapsulation media include microcapsules formed with melamine-formaldehyde resins, aminoplast resins such as polyureas, polyamides, and copolymers of acrylic acid, methacrylic acid, and their esters.Alternatively, the encapsulation media may be formed with natural or modified natural polymers such as polysaccharides or proteins.

[0062] The fragrance compositions of the present invention may be used to impart a desired odor impression to any type of consumer product, such as, for example, hydroalcoholic fragrances, deodorants, antiperspirants, skin care products, hair care products, laundry care products, home care products, or air fresheners. More specifically, the perfume compositions of the present invention may be employed in laundry care applications, personal care products for treating the hair and / or skin of human subjects, oral care products, and air care products. Consumer products may contain blended mixtures of various functional ingredients such as surfactants, emulsifiers, polymers, fillers, and solvents. These blended mixtures are often referred to as a "base."

[0063] Specific consumer products include, but are not limited to, consumer products intended for application to the body (i.e., skin or hair), to hard surfaces (e.g., kitchen and bathroom counters, ceramic surfaces), to fabrics, and air care benefits (e.g., air fresheners). Such products may take a variety of forms, including, but are not limited to, powders, bars, sticks, tablets, creams, mousses, gels, liquids, sprays, and sheets. The percentage of the fragrance composition contained in such products may range from 0.05% (e.g., as in a low-scent skin cream) to 100% by weight (e.g., as in an air freshener), based on the total weight of the consumer product. Means of incorporating fragrance compositions into consumer products are known. Current techniques may be used to directly incorporate the fragrance composition into the product, or the fragrance composition may be absorbed onto a carrier and then mixed into the product.

[0064] Thus, the present invention also provides a consumer product comprising a fragrance composition of the present invention. In an embodiment of the present invention, the consumer product is a laundry care product.Laundry care products include powder and liquid detergents and fabric softeners, dye removers and pre-wash treatments, conditioners and softeners (including standard and concentrated conditioners, softeners and dryer sheets), laundry aids (including dye removers, ironing aids, bleaches and color care products, and other auxiliary fabric care products), laundry detergents (including washing machine liquid detergents, other washing machine detergents-including powders, capsules and tablets-, and hand washing detergents-including powders, flakes and cakes / bars-), sheet sprays, clothing sprays, laundry fragrances, dryer sachets, perfumed sachets, dryer sheets, laundry soaps, laundry detergents, detergents for delicate fabrics, ironing sprays, starches, perfumed sheets, pillow mists, drawer liner sheets, cedar closet sprays, linen waters, and refills, and combinations thereof.

[0065] In an embodiment of the present invention, the consumer product is a personal care product.Personal care products include soap, shower gel, body cream, body lotion, body mist, fragrance, cosmetics, floating bath oil, aftershave, cream, lotion, deodorant (including stick deodorant), pre-electric shave lotion, aftershave lotion, antiperspirant, shampoo, conditioner, rinse, skin care product, eye make-up, body shampoo, skin protection preparation, lipstick, lip gloss, after bath splash, pre-sun and sun product (including sunscreen).Virtually any chemical product that contacts hair or skin and can contain one or more of the fragrance compositions of the present invention in effective amounts, concentrations or proportions can be considered as a personal care product according to the present invention.

[0066] In an embodiment of the invention, the consumer product is an oral care product. Oral care products include dentifrices, dental creams, gels or tooth powders, dental mouthwashes (including plaque removal liquids), pre- or post-brushing rinse formulations, chewing gums, lozenges, and candies.

[0067] In an embodiment of the present invention, the consumer product is an air care product, including candles and air freshener devices such as liquid electrical air freshener devices, aerosol sprays, pump action sprays, scented candles, membrane permeation devices, liquid wick devices, oil-based gel fragrances, and water-based gels.

[0068] In an embodiment of the present invention, the consumer product is a home care product.Home care products can be used specifically for cleaning, rinsing, care or treatment of industrial, household or shared hard surfaces and textile surfaces; they are aimed at providing benefits such as water repellency, soil release, stain resistance, anti-fog, surface repair, wrinkle prevention, shine, smoothness, etc. to treated surfaces, and / or improving the residuality, impact and / or effectiveness of the active materials contained in the home care product.Thus, the home care compositions according to the present invention include surface cleaning compositions (e.g., glass, floor, counter, bathroom, toilet, sink, appliance and furniture cleaning compositions), disinfectants (e.g., spray and solid air disinfectants, including gels, and spray, solid, liquid and paste surface disinfectants), waxes and other surface protection and / or polishing compositions, and carpet shampoos.

[0069] The method of the present invention may be facilitated by computer means. The computer means may include suitable hardware and software components commonly known and used in the art.

[0070] The computer means may comprise a database of perfume ingredients or perfume compositions in computer readable form. For each perfume ingredient or perfume composition, the database may contain at least one defining parameter, property or function of that ingredient or composition. In particular, for each perfume ingredient or composition, a well-being score may be assigned, defined according to the method described above.

[0071] The computer means may include data processing means constructed and operable to enable a formulator to select perfume ingredients from the database and to calculate a well-being score for a perfume composition containing the selected perfume ingredients. Hereinafter, the present invention will be described in more detail with reference to examples. However, it will be understood that these examples are for illustrative purposes only and are not to be construed as limiting the scope of the present invention.

[0072] Example 1: Development of a well-being measurement standard (WB-18) A. Identifying Well-Being Attributes In a preliminary study, a broad selection of linguistic well-being attributes was examined and those that showed sensitivity to odor effects were retained. The most relevant of these attributes were those that showed significant differences between the control, malodorous and / or fragrance conditions, and importantly, between the pleasant fragrances. This led to a subset of 18 attributes that showed the highest sensitivity to fragrances, following a principal components analysis. The WB-18 attributes so identified are listed in Table 1 below. Each item was rated by a panelist moving a virtual slider on a touch screen. 138 panelists across four different studies completed the ratings.

[0073] Panelists first completed two baseline measurements of the WB-18 attributes in the absence of and prior to exposure to the test fragrance composition, with a second baseline measurement completed immediately after the first. Factor analysis (see above) was applied to the averaged baseline data to determine the five well-being factors and associated variances, as well as the loadings for each well-being attribute within the five well-being factors (see Table 1). Factor loadings were based on principal axis factor analysis with oblimin rotation due to possible correlations between some of the well-being attributes. [Table 2] Table 1: Well-being attributes, factors and factor loadings obtained from principal component analysis

[0074] Based on the above analysis, weights for each well-being attribute were determined as shown in Table 2: [Table 3] Table 2: Weighting of well-being attributes

[0075] B. Methodology Protocol for Well-Being Research 690 subjects (283 males and 407 females) between the ages of 21 and 53 were recruited for this study. The subjects had normal or corrected vision, were native English speakers, and were recruited from the general public in the UK. All subjects stated that, to the best of their knowledge, they had no deficiencies in their sense of smell, olfactory hypersensitivity, or neurological disorders. The test fragrance composition was applied onto a Sorbarod made of extruded polyester fiber rods, such as Porex. Each participant received four different samples with the test fragrance composition and was instructed to smell and score online, one sample per day, at approximately the same time of their choosing. Each day, participants first scored the WB-18 attributes in the absence of the test fragrance compositions.

[0076] Participants were then instructed to take three sniffs from the Sorbarod on which the test fragrance composition had been applied, and additionally three more sniffs after completing 50% of the test. Well-being attributes were randomly assigned for each participant for each assessment.

[0077] After completing the scoring of all WB-18 attributes for the four samples, on the fourth day participants were asked to provide a series of ratings of the test fragrance compositions they had smelled over the four days. The order of the samples was again randomized, with instructions to smell each sample individually and complete a rating for each sample before smelling the next. For each test fragrance composition, participants provided a liking rating on a scale of 1 (I dislike it extremely) to 9 (I like it extremely). [Table 4]

[0078] In addition, participants provided an intensity rating on a scale of 1 (extremely weak) to 9 (extremely strong). [Table 5]

[0079] C. Measuring the effect of test fragrance compositions on well-being Eighteen test fragrance compositions with estimated equal liking scores were selected by a panel of two experts. The strength (intensity) of these 18 test fragrance compositions was estimated by a panel of 15 experienced panelists, and a dilution factor was defined according to the strength difference between all the test fragrance compositions and the test fragrance composition with the lowest intensity in the set. The dilution factor was used to equalize the odor intensity of the test fragrance compositions. Thus, the 18 test fragrance compositions prepared were applied to Sorbarod and subjected to the study participants for well-being assessment according to the method described in Section B.

[0080] Participants were asked to provide a first individual well-being score for each well-being attribute in the absence (w / o) of the test fragrance composition (=base) well-being score x i , as well as (w) a second individual well-being score y in the presence of each test fragrance composition. i were provided to assess the WB-18 attributes. The corresponding well-being score was calculated by multiplying the individual scores of each well-being attribute by the weightings as determined in Section A (see Table 2) and summing the individual scores.

[0081] Finally, the well-being enhancement score is calculated by multiplying the base well-being score (i.e. the first individual well-being score x i The sum of the weights multiplied by the weights) was used as the well-being score for the test fragrance composition (i.e., the second individual well-being score y i The mean results across all participants are shown in Table 3. [Table 6] Table 3: Averaged well-being scores before and after smelling the test fragrance compositions, and well-being enhancement in percentage

[0082] Example 2: Identifying odor attributes related to positive impact on well-being For the 18 test fragrance compositions evaluated in Section C of the Examples, the odor attributes of the contained fragrance ingredients were determined. In order to provide maximum differentiation of the 18 fragrance compositions in a two-dimensional image of the odor space, a Principal Component Analysis (PCA) was performed. Each test fragrance composition was tagged by its well-being enhancement rating (last column of Table 3). Overall, ten odor attributes were found to correlate with enhanced well-being, and six of them were associated with strong well-being enhancement: [Table 7]

[0083] [Table 8-1]

[0084] [Table 8-2]

[0085] [Table 8-3]

[0086] [Table 8-4] Table 4: Compositions based on odor description of test fragrance compositions 1 to 17

[0087] [Table 9-1]

[0088] [Table 9-2]

[0089] [Table 9-3]

[0090] [Table 9-4] Table 5: Composition based on odor description of test fragrance compositions 10 to 18

[0091] [Table 10-1]

[0092] [Table 10-2]

[0093] [Table 10-3]

[0094] [Table 10-4]

[0095] [Table 10-5] Table 6: Ingredients used in test fragrance compositions 1-18

[0096] Example 3: Lack of correlation between well-being perceptions and preferences / intensity To ensure that the impact on well-being was not coupled with liking and / or intensity of the tested fragrance compositions, a principal components analysis was performed on the panelists' personal ratings of liking and intensity (Example 1, Section B) and the well-being scores (Example 1, Section C). The corresponding correlation coefficients are reported in Table 7: [Table 11] Table 7: Correlation matrix relating fragrance preference, fragrance intensity, and well-being scores

[0097] As is evident from Table 7, well-being scores do not correlate with variation in fragrance preferences among panelists, nor with variation in fragrance intensity perception among panelists.

Claims

1. A method for assessing the effect of a test fragrance composition on the well-being of a human subject by carrying out the following steps: 1) calculating a baseline well-being score in the absence of the test fragrance composition by having one or more human subjects (singular or plural) score a number of well-being attributes in the absence of the test fragrance composition, multiplying the scores for each well-being attribute by a corresponding weight to produce a product, and summing these products for all well-being attributes; i. where the well-being attributes include "not anxious," "not sad," "not busy," "not on edge," "not stressed," "happy," "optimistic," "excited," "contented," "motivated," "energetic," "curious," "not bored," "not tired," "mentally alert," "calm," "complacent," and "perseverant"; and ii. where each well-being attribute has a weight; 2) repeating step 1) in the presence of the test fragrance composition to determine a well-being score with the test fragrance composition; and 3) Determine the effect of the test fragrance composition on well-being by subtracting the baseline well-being score from the well-being score with the test fragrance composition.

2. The method of claim 1 , wherein the weights of the well-being attributes are: 【Table 1】 。

3. 1. A method for preparing or optimizing a fragrance composition for enhancing well-being in a human subject, the method comprising the steps of: 1-3) Determining the effect of one or more fragrance composition(s) on the well-being of a human subject according to the method of claim 1 or 2; and 4) Selecting fragrance compositions with a positive impact on well-being; The method comprising:

4. Steps below: 5) To compare the perfume ingredients present in those perfume compositions that have a positive impact on well-being; 6) Identifying odor attributes common to those fragrance compositions; and 7) creating new perfume compositions with an increased proportion of perfume ingredients with the odorants identified in step 6); The method of claim 3 further comprising:

5. 5. The method according to claim 4, wherein in step 7) the proportion of one or more perfume ingredients having odor attributes selected from the group consisting of "Citrus-Mandarin", "Citrus-Orange", "Floral-Orange Flower", "Animal-Dung", "Floral-Medicinal", "Fruity-Candied Fruit", "Spicy-Cinnamon", "Sweet-Tonka", "Citrus-Lime" and "Spicy-Clove" is increased.

6. A fragrance composition for enhancing well-being in a human subject prepared or optimized by the method of any one of claims 3 to 5, comprising fragrance ingredients from at least three groups, each group having a different odor attribute, wherein the odor attributes of the groups are selected from the group consisting of "Citrus-Mandarin", "Citrus-Orange", "Floral-Orange Flower", "Animal-Dung", "Floral-Medicinal", "Fruity-Candied Fruit", "Spicy-Cinnamon", "Sweet-Tonka", "Citrus-Lime" and "Spicy-Clove", The fragrance composition comprises: one or more perfume ingredients having a "citrus-orange" odor attribute at a concentration of 0.1 to 25% by weight; and / or one or more perfume ingredients having a "citrus-lime" odor attribute at a concentration of 0.05 to 5% by weight; and / or one or more perfume ingredients having a "citrus-mandarin" odor attribute at a concentration of 0.05 to 5% by weight; and / or one or more perfume ingredients having the odor attribute "sweet tonka" at a concentration of 0.05 to 1% by weight; and / or one or more perfume ingredients having a "fruity - candied fruit" odor attribute at a concentration of 0.01 to 1% by weight; and / or one or more perfume ingredients having a "floral-orange flower" odor attribute at a concentration of 0.01 to 1% by weight; and / or one or more fragrance ingredients having the odor attribute "floral-orange medicinal" at a concentration of 0.01 to 1.0% by weight; and / or one or more perfume ingredients having the odor attribute “spicy-clove” at a concentration of 0.005 to 0.7% by weight; and / or one or more perfume ingredients having an "animal-feces" odor attribute at a concentration of 0.005 to 0.07% by weight; and / or one or more perfume ingredients having the odor attribute "spicy cinnamon" in a concentration of 0.0001 to 0.05% by weight, The fragrance composition comprising:

7. one or more perfume ingredients having a "citrus-orange" odor attribute selected from the group consisting of ORANGE OILS and ORANGE RECONSTITUTIONS, ORANGE OIL COLORLESS, ORANGE OIL CONCENTRATED, ORANGE ESSENCE, ORANGE TERPENE, BIGARADE PHASE OIL, TANJELO OIL, natural orange carbonyl and aldehyde, and mixtures thereof; and / or - CYMENE PARA (4-methyl-1-isopropylbenzene), CEDRAT OIL, CITRATHAL R (1,1-diethoxy-3,7-dimethylocta-2,6-diene), DELTA-3-CARENE (3,7,7-trimethylbicyclo[4.1.0]hept-3-ene), DIPENTENE (1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene), ELEMI OIL, 50% ELEMI RESINOID IN BENZYL BENZOATE, LEMON GREEN PHASE OIL, LIME DIENES, LIME OIL DISTILLED, LIME OIL EXPRESSED, LIME OXIDE, LIME TERPENE RECONSTITUTION, OCIMENE ((E)-3,7-dimethylocta-1,3,6-triene), TERPINENE and / or one or more perfume ingredients having a "citrus-lime" odor attribute selected from the group consisting of ALPHA (1-methyl-4-propan-2-ylcyclohexa-1,3-diene), TERPINENE GAMMA (1-methyl-4-propan-2-ylcyclohexa-1,4-diene), TERPINEOL (2-(4-methyl-3-cyclohexen-1-yl)-2-propanol) and TERPINOLENE (1-methyl-4-propan-2-ylidenecyclohexene), and mixtures thereof; and / or one or more perfume ingredients having a "citrus-mandarin" odor attribute selected from the group consisting of CLEMENTINE OIL, DIMETHYL ANTHRANILATE (methyl 2-methylaminobenzoate), MANDARIN OIL, MANDARIN OIL COLORLESS, MANDARIN GREEN OIL, MANDARIN YELLOW OIL, MANDARIN PHASE OIL, TAMARINE OIL, TAMARINE RECONSTITUTIONS, TANGERINE OIL, TANGERINE RECONSTITUTION, TANGERINOL ((E)-6,10-dimethylundeca-5,9-dien-2-yl acetate), and mixtures thereof; and / or - BICYCLO NONALACTONE (3,4,4a,5,6,7,8,8a-OCTAHYDROCHROMEN-2-ONE), COUMARIN (CHROMEN-2-ONE), TOLYL ALDEHYDE PARA (4-METHYLBENZALDEHYDE), COUMARIN RECONSTITUTION, FLOUVE OIL, FLOUVE RECONSTITUTION, HAY OIL, HAY ABSOLUTE, KOUMALACTONE (3,6-DIMETHYL-3a,4,5,6,7,7a-HEXAHYDRO-3H-BENZOFURAN-2-ONE), MARSHALLOW ABSOLUTE, MATE ABSOLUTE, MATE RECONSTITUTION, METHYL OCTALACTONE (5-BUTYL-4-METHYLOXOLANE-2-ONE), TONKAROSE ((E)-DECA-9-EN-1-YL 3-(2-HYDROXYPHENYL)ACRYLATE), SESAME ROASTED ABSOLUTE, TOBACCO LEAF ABSOLUTE, TONKA ABSOLUTE, TONKA ABSOLUTE COLORLESS, TONKA BEAN OIL, ACETANISOLE (1-(4-METHOXYPHENYL)ETHANONE), ACETOPHENONE EXTRA (1-PHENYLETHANE), ANISIC ALDEHYDE (4-METHOXYBENZALDEHYDE), ANISYL ALCOHOL ((4-METHOXYPHENYL)METHANOL), AUBEPINE PARA CRESOLS (4-METHOXYBENZALDEHYDE), DIMETHYL HYDROQUINONE CRYSTALS (1,4-DIMETHYL BENZENE), HELIOTROPINE CRYSTALS (BENZO[d][1,3]DIOXOLE-5-CARBALDEHYDE), HYDRATROPIC ALDEHYDE (2-PHENYLPROPANAL), METHYL ACEOPHENONE (1-(p-TOLYL)ETHANONE), MIMOSA ABSOLUTE, VERATRYL One or more perfume ingredients having a "sweet-tonka" odor attribute selected from the group consisting of: ALDEHYDE (3,4-dimethoxybenzaldehyde), and mixtures thereof; and / or - CRISTALON (ethyl 2,6,6-trimethylcyclohexa-1,3-diene-1-carboxylate), GIVESCONE (ethyl 2-ethyl-6,6-dimethylcyclohex-2-ene-1-carboxylate), DAMASCENONE ((E)-1-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)but-2-en-1-one), DAMASCONE ALPHA ((E)-1-(2,6,6-trimethyl-1-cyclohex-2-enyl)but-2-en-1-one), DAMASCONE BETA ((E)-1-(2,6,6-trimethyl-1-cyclohexenyl)but-2-en-1-one), DAMASCONE and / or one or more fragrance ingredients having "fruity-candied fruit" odor attributes selected from the group consisting of DELTA (1-(2,6,6-trimethyl-1-cyclohex-3-enyl)but-2-en-1-one, and POMAROSE ((2E,5Z)-5,6,7-trimethylocta-2,5-dien-4-one), and mixtures thereof; and / or one or more perfume ingredients having "floral-orange flower" odor attributes selected from the group consisting of ORANGE FLOWER RECONSTITUTIONS, METHYL ANTHRANILATE (methyl 2-aminobenzoate), ORANGER CRYSTALS (1-naphthalen-2-ylethanone), JASMIN SAMBAC OIL, and mixtures thereof; and / or one or more perfume ingredients having a "floral-medicinal" odor attribute selected from the group consisting of YARA YARA (2-methoxynaphthalene), CRESYL METHYL ETHER PARA (1-methoxy-4-methylbenzene), ETHYL BENZOATE, ETHYL SALICYLATE, METHYL BENZOATE, METHYL SALICYLATE, TEBERUSE FLOWER RECONSTITUTIONS, and mixtures thereof; and / or one or more perfume ingredients having a "spicy-clove" odor attribute selected from the group consisting of EUGENYL ACETATE ((2-methoxy-4-prop-2-enylphenyl) acetate), ACETYL ISOEUGENOL (2-methoxy-4-prop-1-en-2-ylphenol acetate), crude, colorless and rectified CLOVE LEAF OIL, DIHYDRO EUGENOL (2-methoxy-4-propylphenol), EUGENOL (2-methoxy-4-prop-2-enylphenol), and ISO EUGENOL (2-methoxy-4-prop-1-en-2-ylphenol), and mixtures thereof; and / or one or more perfume ingredients having an "animal-feces" odor attribute selected from the group consisting of INDOLE and INDOLENE (8,8-bis(1H-indol-3-yl)-2,6-dimethyloctan-2-ol), INDOFLOR (4,4a,5,9b-tetrahydroindeno[1,2-d][1,3]dioxine), and mixtures thereof; and / or one or more perfume ingredients having a "spicy cinnamon" odor attribute selected from the group consisting of CINNAMIC ALDEHYDE (3-phenylprop-2-enal), CINNAMALVA ((E)-3-phenylprop-2-enenitrile), CINNAMON BARK OIL; METHYL CINNAMIC ALDEHYDE ((Z)-2-methyl-3-phenylacrylaldehyde), and mixtures thereof; The fragrance composition of claim 6, comprising:

8. at least five perfume ingredients selected from the group consisting of CITRONELLOL (3,7-dimethyloct-6-en-1-ol), DECALACTONE GAMMA (5-hexyloxolan-2-one), GARDENOL (1-phenylethyl acetate), HEXENOL-3-CIS ((Z)-hex-3-en-1-ol), IONONE BETA (4-(2,6,6-trimethylcyclohexen-1-yl)but-3-en-2-one), LINALOOL (3,7-dimethyloct-1,6-dien-3-ol), LINALYL ACETATE (3,7-dimethyloct-1,6-dien-3-ol acetate) and PEACH PURE (5-heptyloxolan-2-one); or At least five perfume ingredients selected from the group consisting of CITRONELLOL (5-heptyloxolan-2-one), ETHYLENE BRASSYLATE (1,4-dioxacycloheptadecane-5,17-dione), BENZYL ACETATE, HEDIONE (methyl 3-oxo-2-pentylcyclopentane acetate), LINALLOL (3,7-dimethylocta-1,6-dien-3-ol), ISO E SUPER (1-(2,3,8,8-tetramethyl-1,3,4,5,6,7-hexahydronaphthalen-2-yl)ethanone), PHENYL ETHYL ALCOHOL, ETHYL VANILLIN, and VANILLIN.

8. The fragrance composition according to claim 6 or 7, comprising INDOLE in combination with

9. 9. The fragrance composition of any one of claims 6 to 8 comprising DAMASCENONE in combination with at least five fragrance ingredients selected from the group consisting of CITRONELLOL (3,7-dimethyloct-6-en-1-ol), GARDENOL (1-phenylethyl acetate), HEXENYL-3-CIS ACETATE ((Z)-hex-3-en-1-ol), IONONE BETA ((4-(2,6,6-trimethylcyclohexen-1-yl)but-3-en-2-one), LINALOOL (3,7-dimethylocta-1,6-dien-3-ol), LINALYL ACETATE (3,7-dimethylocta-1,6-dien-3-ol acetate), and PEACH PURE (5-heptyloxolan-2-one).

10. A consumer product comprising a fragrance composition according to any one of claims 6 to 9 and a suitable base.

11. Use of a fragrance composition according to any one of claims 6 to 9 for enhancing the well-being of a human subject.

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