Anti-hair loss ingredients

Abstract

The compositions for promoting hair growth and / or reducing or preventing hair loss each comprise sandalpentanol, caffeine, one or more saturated and unsaturated C10-C18 fatty acids, and a solvent.

Description

[Technical field]

[0001] The present invention relates to a cosmetic composition, in particular a hair tonic for reducing or treating hair loss. The composition contains an active ingredient combination of sandalpentanol, caffeine and one or more saturated or unsaturated C10-C18 fatty acids or salts thereof. The subject of the present invention also includes a cosmetic method for promoting natural hair growth and reducing hair loss. [Background technology]

[0002] Human hair growth occurs in a known manner, following a natural growth rhythm that includes a growth phase (anagen), a transitional phase (catagen) and a resting phase (telogen). The normal natural hair cycle begins when the root of the hair is expelled or eliminated at the beginning of the anagen phase. As a result, between 80 and 100 hairs are shed from the scalp every day. This number is approximate, and although this amount may be shed in a shorter period of time, or more or less hairs may be shed, this does not indicate any concern regarding natural hair growth. However, if the amount of hair shed each day exceeds this approximate normal amount, irreversible or reversible hair loss is occurring.

[0003] Androgenetic (male pattern) alopecia is the most common type of hair loss and is typically genetically determined. It is caused by an increased sensitivity of certain areas of the scalp to dihydrotestosterone (DHT) and is passed down from generation to generation. DHT is converted from the male hormone testosterone by the enzyme 5-alpha-reductase. There are receptors on the hair follicle cells that bind to DHT. After binding to the receptor, DHT enters the cell and interacts with the cell nucleus, altering the DNA in the nucleus from producing hair protein (keratin). Eventually the hair follicle stops growing. The hair growth cycle is affected in that the percentage of hairs in the growth phase (anagen) and the duration of the growth phase are reduced, resulting in shorter hairs. More hairs are in the resting state (telogen) and these hairs are much more susceptible to loss from the everyday trauma of combing and washing. Hair shafts in male pattern baldness progressively shrink over time, becoming shorter in diameter and length. In men with male pattern baldness, it is possible (but not necessarily) that all hairs in the affected area will eventually become incorporated into the process, and over time, the area may become covered with fine (vellus-like) hairs. These fine hairs become lighter in color because pigment (color) production ceases as they shrink. The lighter, smaller hairs are what make the area appear thin first.

[0004] The condition usually begins in men in their 20s and 30s and follows a typical pattern: first, the hairline recedes, then the hair on the top of the head starts to thin, and eventually the two areas of baldness join together to form the classic U-shape that surrounds the back and sides of the head.

[0005] Besides genetic predisposition, hair loss can also occur after febrile and debilitating illnesses. Hair loss can occur as a result of an unbalanced diet due to dietary iron deficiency caused by an albumin-free diet during fasting treatments, and as a result of the administration of cancer drugs. Hair loss also occurs in women after childbirth. Hormones called gestagens are formed in large amounts during pregnancy and synchronize the hair growth cycle on the head. The result is a very high ratio of anagen hair to telogen hair. After childbirth, this ratio changes inversely, meaning that many anagen hairs are transformed into telogen hair. After a few months, the transition to the anagen phase occurs, during which the hairs fall out simultaneously, which can result in areas of the scalp where the scalp hair is clearly exposed. Once the new anagen hairs have reached their original length, they will return to their original state. Hair loss after extreme psychological stress is another form of reversible hair loss. How this type of hair loss occurs is not known. Stress can impair many of the human metabolic functions and appears to affect the functioning of the hair apparatus, which is continually working at peak performance.

[0006] There is therefore a need for care products adapted to reduce or prevent hair loss, promote hair growth, strengthen hair and / or accelerate hair growth. In particular, there is a need for such products that can be administered topically.

[0007] EP0116439A2 discloses a hair tonic composition containing at least one specific C10-C20 fatty acid or its salt as an active ingredient, which is said to prevent the occurrence of dandruff and scalp itching in hair and accelerate hair growth.

[0008] US2002 / 0034485A1 discloses a hair tonic for preventing or at least reducing hair loss, comprising at least one saturated and unsaturated C10-C18 fatty acid or a salt thereof, biotin and / or caffeine.

[0009] US2019 / 0216696A1 discloses the use of certain derivatives of sandalpentanol for promoting hair growth and / or inhibiting or delaying hair loss in the human scalp.

[0010] WO2020 / 069522A1 discloses a cosmetic formulation comprising an effective amount of sandalpentanol or an analogue thereof and minoxidil or rosemary oil or emu oil or a combination thereof for the treatment and regrowth of hair loss in mammals. Summary of the Invention

[0011] According to the present invention, it has now surprisingly been found that a composition containing a combination of active ingredients, namely sandalpentanol, caffeine and a C10-C18 fatty acid, is effective in promoting hair growth and / or reducing or preventing hair loss. The combination of active ingredients in the composition according to the present invention has been found to be more effective than these active ingredients used individually.

[0012] According to one embodiment, the subject of the present invention is a composition for promoting natural hair growth and / or reducing hair loss, in particular in mammals, such as humans, comprising sandalpentanol, caffeine, one or more saturated and unsaturated C10-C18 fatty acids, and a solvent.

[0013] The composition may further comprise one or more components that provide a beneficial effect (referred to herein as "supportive components"), one or more oil components, one or more mineral components, and one or more cosmetically acceptable additives.

[0014] According to an embodiment, the composition is a hair tonic comprising a water-alcohol based solvent system.

[0015] According to another embodiment, the composition is a dry shampoo, in particular a dry shampoo applied in the form of an aerosol.

[0016] According to an embodiment, the composition is a ready-to-use scalp and hair treatment product selected from a hair tonic, a hair lotion, a hair conditioner, a hair cream, a hair shampoo, a dry shampoo, a hair rinse, a hair liquid, a hair oil, a hair pomade, a hair foam, and a hair spray.

[0017] According to another aspect, the subject of the invention is a hair tonic comprising specific amounts of sandalpentanol, caffeine and C10 to C18 fatty acids, in combination with specific and / or optional ingredients.

[0018] According to yet another aspect, the subject of the invention is a hair tonic consisting essentially of sandalpentanol, caffeine and C10 to C18 fatty acids in specific amounts, in combination with specific and / or optional ingredients.

[0019] According to yet another aspect, the subject of the present invention is a method for reducing or treating hair loss, comprising applying to the scalp a composition or a hair tonic according to the subject invention.

[0020] According to a further aspect, the subject of the present invention is the use of a composition or a hair tonic according to the subject invention for promoting natural hair growth in a mammal and / or for reducing hair loss in a mammal.

[0021] According to yet a further aspect, a subject of the present invention is a composition or a hair tonic according to the subject invention for use in the treatment of alopecia in a mammal.

[0022] The composition of the present invention is suitable for promoting hair growth and / or inhibiting or slowing hair loss.The composition is further suitable for topical administration to human scalp.The composition of the present invention is suitable for both cosmetic and therapeutic use in promoting hair growth and / or treating hair loss on human scalp.

[0023] When the active ingredient combination according to the present disclosure is applied to the scalp, the activity of the enzyme 5-α-reductase can be reduced or inhibited. This reduces the amount of 5-α-dihydrotestosterone formed, which is responsible for human hair loss. It also increases the blood supply in the application area with blood flow, which in turn provides nutrients to the hair organ. It can increase the keratinization, tear resistance, strength, and therefore resistance of hair to environmental influences and treatments. It can strengthen the anchorage of the hair root to the scalp. It can reduce the number of hairs that fall out and stabilize hair loss at a low level.

[0024] definition In the following, the terms "sandalpentanol" and "Sandalore" are used interchangeably. Sandalpentanol is a synthetic odorant with a sandalwood-like fragrance and is therefore used in perfumes, emollients and skin cleansers as a less expensive ingredient to mimic the scent of sandalwood. Sandalpentanol, along with its structurally similar analogues such as the compound named Brahmanol, is an alcohol with a completely different chemical structure from the ingredients of natural sandalwood oil. Sandalwood oil is extracted by steam distillation from mature sandalwood trees and is a well-known and valuable perfume ingredient. The IUPAC name for sandalpentanol is 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol.

[0025] As used in this specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise.

[0026] The terms "may," "can," and "may," in the context of this application, mean "is permitted to" or "is able to" and are synonymous with the term "can." The terms "can," "possible," and "may," as used herein, do not imply possibility or probability.

[0027] The term "and / or" means, in the context of this application, one or the other or both. For example, an aqueous solution of A and / or B means an aqueous solution of A alone, an aqueous solution of B alone, and an aqueous solution of A and B in combination.

[0028] The term "about" should be understood to mean ±10 percent of a stated number, number or range of values. According to an embodiment, the term "about" should be understood to mean ±2 percent of a stated number, number or range of values.

[0029] In this specification, the term "optionally" means that the corresponding step or feature may or may not be present. The term encompasses both possibilities.

[0030] The terms "parts by weight" (PBW) and "parts by volume" (PBV) are used in their ordinary sense. When used in a complex context, such as the amount of a PBW component in a mixture with a PBV component, the terms PBW and PBV herein refer to the amount of the PBV component in milliliters by volume, whereas the PBW component is the amount in grams.

[0031] The term "composition" as used herein refers to a mixture or blend that includes at least two components. A typical composition includes at least one functional component (e.g., an active ingredient such as sandalpentanol) and at least one solvent component (e.g., water or alcohol). The composition can be in any suitable physical form, including, for example, liquids of various consistencies, gels, foams, creams, and the like. The term "composition" can refer to a ready-to-use product, unless the context dictates otherwise.

[0032] "Ready-to-use scalp and hair treatment product" refers to the composition being in a form that is actually applied to the human scalp and hair.

[0033] The term "substantially free" of a certain component refers to an amount of the respective component in an entity, e.g., a composition, that is less than 1.0% by weight, based on the total weight of the entity. In particular, the term "substantially free" refers to an amount of the respective component in an entity that is less than 0.5% by weight, e.g., less than 0.1% by weight, e.g., less than 0.01% by weight, etc.

[0034] The term "free of" a certain component refers to an amount below the detection limit, assuming that the detectability is on a ppm (parts per million) basis (by weight). In particular, the term "free of" a certain component refers to an amount of the corresponding component in the entity that is less than 50 ppm by weight, for example less than 10 ppm by weight, e.g., less than 5 ppm by weight.

[0035] The term "consisting essentially of" refers to the absence in an entity, e.g., in a composition, of any additional components not specifically recited in an amount greater than 1.0% by weight, based on the total weight of the entity. In particular, the term "consisting essentially of" refers to the absence in an entity of any additional components not specifically recited in an amount greater than 0.5% by weight, e.g., greater than 0.1% by weight, e.g., greater than 0.01% by weight. Needless to say, any additional components not specifically recited are compatible with and do not interfere with the function of the components specifically recited.

[0036] The term "consisting of" refers to the absence of additional components not specifically recited in an entity, e.g., in a composition, below the detection limit, assuming that the detectability is on a ppm (parts per million) basis (by weight). In particular, the term "consisting of" refers to the absence of additional components not specifically recited in an entity, in an amount greater than 50 ppm by weight, e.g., greater than 10 ppm by weight, e.g., greater than 10 ppm by weight. Needless to say, any additional components not specifically recited are compatible with and do not interfere with the function of the components specifically recited. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0037] The inventors of the present invention have surprisingly found that compositions containing a combination of active ingredients of sandalpentanol, caffeine and a C10-C18 fatty acid are synergistically effective in promoting hair growth and / or reducing or preventing hair loss.

[0038] According to an embodiment, the subject of the present disclosure is a composition for promoting natural hair growth in a mammal and / or reducing hair loss in a mammal. The composition comprises sandalpentanol, caffeine, one or more saturated and unsaturated C10-C18 fatty acids, and a solvent.

[0039] 1. Active ingredient combination The active ingredients of the compositions according to the present disclosure include: Sandalpentanol, also known as Sandalore, Caffeine and one or more saturated and / or unsaturated C10-C18 fatty acids Includes combinations of.

[0040] Sandalpentanol is the first active ingredient of the active ingredient combination used according to the present disclosure. Sandalpentanol is a synthetic fragrant odorant used as an ingredient to mimic the scent of sandalwood. Sandalpentanol is an alcohol with a chemical structure that is completely different from the components of natural sandalwood oil. Sandalwood oil is usually extracted by steam distillation of wood from mature sandalwood trees. The IUPAC name of sandalpentanol is 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol. Sandalpentanol has been shown to have a stimulating effect on the olfactory receptor OR2AT4 expressed in the epithelium of human hair follicles. Simulation of OR2AT4 by sandalpentanol results in a prolonged period of ex vivo hair growth by reducing apoptosis and increasing the production of the growth factor IGF-1. Sandalpentanol is therefore believed to act as an agonist to promote hair growth in mammals.

[0041] Analogs or derivatives of sandalpentanol, each of which is believed to have a similar effect on mammalian hair growth, may be used in the present disclosure in place of or in addition to sandalpentanol. Sandalpentanol analogs that are compatible as active ingredients include: (4Z)-3-Methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol (Sandalpentenol) 1-Methyl-2-((1,2.2-trimethylbicyclo(3.1.0)hex-3-yl)methyl)-cyclopropane-methanol (Sandalcyclopropane) (E)-3,3-Dimethyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol (santol pentenol) 2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)butanol (Sandalcyclopentane) (E)-2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol (sandalrome) (E)-2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol (Sandalbutenol) Examples include:

[0042] According to an embodiment, the composition according to the present disclosure comprises, in addition to the active ingredient sandalpentanol, one or more of the sandalpentanol analogues mentioned above. When one or more sandalpentanol analogues are present, the sandalpentanol plus one or more sandalpentanol analogues are present in the total amounts as described below for sandalpentanol alone.

[0043] According to other embodiments, compositions according to the present disclosure contain sandalpentanol as the active ingredient and are substantially free or free of the aforementioned sandalpentanol analogues.

[0044] According to further, less preferred embodiments, the compositions according to the present disclosure comprise, instead of the active ingredient sandalpentanol, one or more of the aforementioned sandalpentanol analogues.

[0045] Caffeine is the second active ingredient of the active ingredient combination used according to the present disclosure. Caffeine is a plant alkaloid also known as theine, methyltheobromine and guaranine. Its IUPAC name is 1,3,7-trimethylxanthine. Caffeine is a well-known stimulant present, for example, in coffee, black tea, but also in cocoa solids and products containing cocoa solids (especially dark chocolate) or cola nuts. Caffeine has a vasodilatory effect, thereby increasing the blood and nutrient supply to the hair root. Research has also shown that caffeine enhances the elongation of the hair shaft (enhancing the hair root), prolongs the duration of anagen (increasing the hair growth phase) and stimulates the proliferation of hair matrix keratinocytes (increasing keratin production).

[0046] The third active ingredient of the active ingredient combination used in accordance with the present disclosure is a C10-C18 fatty acid. Research suggests that fatty acids have hair growth promoting effects, and that at least some fatty acids may have an inhibitory effect on the enzyme testosterone-5-α-reductase. This enzyme catalyzes the conversion of testosterone to 5-α-dihydrotestosterone (5α-DHT, or simply DHT). Research has shown that DHT is the primary cause of hair loss in both males and females.

[0047] The fatty acids used in the active ingredient combination are one or more linear and / or branched, saturated and / or unsaturated C10-C18 fatty acids. Typically, the one or more C10-C18 fatty acids will be linear fatty acids. According to an embodiment, the C10-C18 fatty acids can be selected from capric acid (C10:0), lauric acid (C12:0), myristic acid (C14:0), isomyristic acid (C14:0), palmitic acid (C16:0), palmitoleic acid (C16:1), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), linolenic acid (C18:3), parinaric acid (C18:4), petroselinic acid (C18:1) or combinations thereof.

[0048] According to embodiments, the C10-C18 fatty acid can include lauric acid (C12:0), myristic acid (C14:0), or a combination thereof. According to certain embodiments, the C10-C18 fatty acid can be selected from lauric acid (C12:0), myristic acid (C14:0), or a combination thereof. For example, the fatty acid component of the active ingredient combination can be lauric acid (C12:0).

[0049] According to an embodiment, the fatty acid component of the active ingredient combination can include one or more unsaturated fatty acids. It is believed that at least some unsaturated fatty acids may have a higher inhibitory effect on testosterone-5-α-reductase than saturated fatty acids. According to an embodiment, the C10-C18 fatty acid can include palmitoleic acid (C16:1), oleic acid (C18:1), linoleic acid (C18:2), linolenic acid (C18:3), parinaric acid (C18:4), petroselinic acid (C18:1), or a combination thereof. For example, the fatty acid component of the active ingredient combination can include linoleic acid (C18:2).

[0050] According to certain embodiments, the fatty acid component of the active ingredient combination can be selected from palmitoleic acid (C16:1), oleic acid (C18:1), linoleic acid (C18:2), linolenic acid (C18:3), parinaric acid (C18:4), petroselinic acid (C18:1), or combinations thereof. For example, the fatty acid component of the active ingredient combination can be selected from palmitoleic acid (C16:1) and / or linoleic acid (C18:2).

[0051] When the fatty acid component of the active ingredient combination contains one or more unsaturated fatty acids, each corresponding composition preferably contains an antioxidant to reduce autoxidation of double bonds.

[0052] According to embodiments, compositions according to the present disclosure can be substantially free or free of unsaturated C10-C18 fatty acids. According to certain embodiments, compositions according to the present disclosure can be substantially free or free of unsaturated fatty acids themselves.

[0053] The C10-C18 fatty acid may be present in the form of a free acid or in the form of a cosmetically acceptable salt, such as an alkali metal salt, an alkaline earth metal salt, an ammonium salt, or a combination thereof. According to certain embodiments, the C10-C18 fatty acid may be present in the form of a free acid.

[0054] 2. Amount of active ingredient The active ingredients per se and combinations thereof in the compositions according to the present disclosure are present in an amount effective to provide the hair loss reducing and / or hair growth promoting benefits according to the present invention.

[0055] The amount of sandalpentanol in the composition according to the present disclosure is not critical. Typically, sandalpentanol will be present in an amount of 0.010 to 10.0 weight percent relative to the weight of the composition. If the amount is less than 0.010 weight percent, the effect pursued by the present disclosure may be difficult to achieve. Using an amount of more than 10.0 weight percent does not further enhance the effect and contributes to the high cost of the material resources used in the composition according to the present disclosure. According to an embodiment, sandalpentanol can be present in an amount of 0.050 to 5.0 weight percent relative to the weight of the composition. According to a more specific embodiment, sandalpentanol can be present in an amount of 0.10 to 2.0 weight percent relative to the weight of the composition. According to an even more specific embodiment, sandalpentanol can be present in an amount of 0.50 to 1.5 weight percent relative to the weight of the composition.

[0056] When an analogue of sandanol pentanol is present, either at least partially replacing or in addition to sandalpentanol, the total amount of sandalpentanol plus one or more of the sandalpentanol analogues (as described above) is within the ranges described above for when sandalpentanol is proprietary.

[0057] The amount of caffeine in the composition according to the present disclosure is not critical. Typically, caffeine will be present in an amount of 0.010 to 10.0 percent by weight based on the weight of the composition. If the amount is less than 0.010 percent by weight, the effect pursued by the present disclosure may be difficult to achieve. Using an amount greater than 10.0 percent by weight does not further enhance the effect and contributes to the high cost of the material resources used in the composition according to the present disclosure. According to an embodiment, caffeine can be present in an amount of 0.050 to 5.0 percent by weight based on the weight of the composition. According to a more specific embodiment, caffeine can be present in an amount of 0.10 to 2.0 percent by weight based on the weight of the composition. According to an even more specific embodiment, caffeine can be present in an amount of 0.50 to 1.5 percent by weight based on the weight of the composition.

[0058] Similarly, the amount of C10-C18 fatty acid in the composition according to the present disclosure is not critical. Typically, the C10-C18 fatty acid will be present in an amount of 0.010 to 10.0 percent by weight based on the weight of the composition. If the amount is less than 0.010 percent by weight, the effect pursued by the present disclosure may be difficult to achieve. Using an amount greater than 10.0 percent by weight does not further enhance the effect, and contributes to higher costs of the material resources used in the composition according to the present disclosure. Furthermore, a higher amount of C10-C18 fatty acid requires a higher amount of surfactant, which may result in a greasy appearance or feel on the hair. According to an embodiment, the C10-C18 fatty acid may be present in an amount of 0.050 to 5.0 percent by weight based on the weight of the composition. According to a more specific embodiment, the C10-C18 fatty acid may be present in an amount of 0.10 to 2.0 percent by weight based on the weight of the composition. According to an even more particular embodiment, the C10-C18 fatty acid may be present in an amount of 0.50 to 1.5 weight percent, based on the weight of the composition.

[0059] The combination of active ingredients in the composition according to the present disclosure is also not critical. The amount of the active ingredient combination is selected to obtain the effect sought. Typically, sandalpentanol will be present in an amount of 0.010 to 10.0 weight percent, caffeine will be present in an amount of 0.010 to 10.0 weight percent, and one or more C10-C18 fatty acids will be present in an amount of 0.010 to 2.0 weight percent, each based on the weight of the composition. Conveniently, sandalpentanol will be present in an amount of 0.10 to 5.0 weight percent, caffeine will be present in an amount of 0.10 to 5.0 weight percent, and one or more C10-C18 fatty acids will be present in an amount of 0.050 to 3.0 weight percent, each based on the weight of the composition.

[0060] According to an embodiment, sandalpentanol will be present in an amount of 0.50 to 2.0 weight percent, caffeine will be present in an amount of 0.50 to 2.0 weight percent, and one or more C10-C18 fatty acids will be present in an amount of 0.10 to 2.0 weight percent, each relative to the weight of the composition. According to a more particular embodiment, sandalpentanol will be present in an amount of 0.80 to 1.50 weight percent, caffeine will be present in an amount of 0.80 to 1.50 weight percent, and one or more C10-C18 fatty acids will be present in an amount of 0.10 to 1.0 weight percent, each relative to the weight of the composition.

[0061] 3 Optional Benefit Addition Component The compositions according to the present disclosure may optionally contain additional ingredients that enhance, supplement or expand the benefits obtained from the active ingredient combination. Such additional optional ingredients are hereafter referred to as supplementary ingredients, oil ingredients and mineral ingredients. Supplementary ingredients encompass a wide range of substances that have diverse effects on physiological or metabolic processes. Oil ingredients encompass natural essential oils and modified oils. Modified oils include, inter alia, hydrogenated oils and oil constituents. Mineral ingredients encompass soluble forms of minerals.

[0062] According to an embodiment, the composition according to the present disclosure may further comprise an auxiliary component. Examples of such an auxiliary component include, inter alia, vasodilators, blood circulation stimulants, antioxidants, vitamins, and provitamins. When present, the amount of the auxiliary component or combinations thereof may range from 0.0010 to 5.0 weight percent, in particular from 0.010 to 3.0 weight percent, based on the weight of the composition.

[0063] Supplementary ingredients can include, for example, one or more of tocopherol, tocotrienol, tocopherol esters, nicotinic acid, nicotinamide, nicotinic acid esters, vasodilatory plant extracts, camphor, royal jelly, biotin, vitamin B3, vitamin B12, vitamin C, vitamin D2, vitamin D3, vitamin E, vitamin K1, vitamin K2, panthenol (provitamin B5), omega-3 fatty acids, omega-6 fatty acids, folate, cannabidiol, saw palmetto, minoxidil, or combinations thereof.

[0064] According to an embodiment, the auxiliary components include vasodilators selected from tocopherol (α-, β-, γ- or δ-tocopherol), especially α-tocopherol, tocopherol esters (examples include tocopherol acetate, tocopheryl succinate, tocopheryl nicotinate, tocopheryl poly(oxyethylene) succinate), nicotinic acid, nicotinamide, nicotinic acid esters, camphor; antioxidants, such as vitamin C or polyphenols; testosterone-5-α-reductase inhibitors, such as ω-6 fatty acid arachidonic acid; substances that benefit hair health, such as nicotinamide (niacinamide); or combinations thereof. According to an embodiment, the auxiliary components include tocopherol or tocopheryl acetate (vitamin E acetate) and / or niacinamide. Suitable vasodilatory plant extracts include nettle extract (Urtica Diocia) by burning or distillation, chestnut extract (Aesculus Hippocastanum) by roasting, arnica extract (Arnica Montana) or hemp extract.

[0065] The oil component can include, for example, peppermint oil, rosemary essential oil, lavender essential oil, tea tree oil, ylang ylang, thyme oil, cedarwood oil, clary sage essential oil, bergamot oil, jojoba oil, sunflower oil, hydrogenated olive ethylhexyl, or combinations thereof. Such oil components can, among other things, promote hair growth, contribute to scalp health, or strengthen hair. When present, the oil component will be present in the composition of the present disclosure in an amount of 0.0010 to 1.0 weight percent, and particularly 0.010 to 0.50 weight percent, based on the weight of the composition.

[0066] According to an embodiment, the oil component includes peppermint oil and / or hydrogenated olive ethylhexyl oil.

[0067] Mineral components include metal ions that provide beneficial effects on hair growth and / or scalp health. Mineral components can include, for example, iron, zinc, or combinations thereof. When present, mineral components will be present in the compositions of the present disclosure at 0.0050 to 0.50 molar, for example, 0.010 to 0.25 molar.

[0068] Compositions according to the present disclosure may include adjunct ingredients, oil ingredients, or mineral ingredients, alone or in any combination.

[0069] 4 Solvent or carrier system and pH range The solvent system used in the composition of the present disclosure is water-based, alcohol-based or water-alcohol-based. Typically, the solvent comprises water and one or more monohydric and / or polyhydric C1-C4 alcohols. According to an embodiment, the solvent comprises water and an alcohol selected from ethanol, n-propanol, isopropanol, glycerol, ethylene glycol, propylene glycol or a combination thereof.

[0070] The solvent can further comprise one or more solubilization enhancers.The solubilization enhancers are obviously intended to solubilize compounds that are not soluble or only partially soluble in the solvent at the concentration used in the composition.The solubilization enhancers generally include surfactants.Surfactants include anionic, cationic, amphoteric and nonionic surfactants.

[0071] The anionic surfactant can be selected from the group consisting of the salts (e.g., alkaline salts, such as sodium salts, ammonium salts, amine salts, amino alcohol salts and magnesium salts) of the following compounds: alkyl sulfates, alkyl ether sulfates, alkyl amido ether sulfates, alkylaryl polyether sulfates, monoglyceride sulfates; alkyl sulfonates, alkyl phosphates, alkyl amido sulfonates, alkyl aryl sulfonates, α-olefin sulfonates, paraffin sulfonates; alkyl sulfosuccinates, alkyl ether sulfosuccinates, alkyl amido sulfosuccinates; alkyl sulfosuccinamates; alkyl sulfoacetates; alkyl ether phosphates; acylsarcosinates; acylisethionates; N-acyltaurates; and mixtures thereof. The alkyl or acyl radicals of all these various compounds contain, for example, 8 to 24 carbon atoms, and the aryl radicals are, for example, selected from phenyl and benzyl groups. Weak anionic surfactants, such as alkyl-D-galactosiduronic acid and its salts, and polyoxyalkylenated (C6-C 24 ) Alkyl ether carboxylic acid, polyoxyalkylenated (C6-C 24 ) Alkyl aryl ether carboxylic acids, polyoxyalkylenated (C6-C 24) Alkyl amido ether carboxylic acids and their salts, such as those containing from 2 to 50 ethylene oxide groups, as well as mixtures thereof, can also be used. Anionic derivatives of polysaccharides can also be used, such as carboxyalkyl ethers of alkyl polyglucosides.

[0072] Suitable anionic surfactants may include at least one anionic functional group at their head selected from sulfate, sulfonate, phosphate and carboxylate. To avoid duplication with the active ingredient combinations of the present disclosure, anionic surfactants for use in compositions according to the present disclosure exclude fatty acids or salts thereof.

[0073] Suitable alkyl sulfates include ammonium lauryl sulfate, sodium lauryl sulfate (sodium dodecyl sulfate, SLS or SDS), and alkyl ether sulfates such as sodium laureth sulfate (sodium lauryl ether sulfate or SLES) and sodium myreth sulfate.

[0074] Further suitable anionic surfactants can include docusate (dioctyl sodium sulfosuccinate), alkyl aryl ether phosphates, alkyl ether phosphates, sodium lauroyl sarcosinate, ammonium laureth sulfate, disodium lauryl sulfosuccinate, and sodium lauryl sulfoacetate.

[0075] Preferred anionic surfactants can be selected from the group consisting of sodium lauryl ether sulfate, sodium laureth ether sulfate, sodium dodecyl sulfate, ammonium laurethethersulfat, ammonium dodecyl sulfate, alkylbenzenesulfonates, and combinations thereof.

[0076] The surfactant can be a non-ionic surfactant. The non-ionic surfactant can be selected from the group consisting of lanolin alcohol and polyoxyethylene ethers of fatty alcohols, and mixtures thereof. The non-ionic surfactant can preferably be ceteareth-n, where n is from 2 to 100, or from 10 to 30. Suitable non-ionic surfactants are well-known compounds (for example, see "Handbook of Surfactants", MR Porter, Blackie & Son, Glasgow and London, 1991, pages 116-178).

[0077] Preferred surfactants include nonionic surfactants, particularly polyoxyethylated fatty alcohols or oils.Particularly preferred nonionic surfactants include polyoxyethylated castor oil and hydrogenated polyoxylated castor oil.Specific examples of nonionic surfactants that can be used in the composition of the present disclosure are PEG-35 castor oil, PEG-40 hydrogenated castor oil, and combinations thereof.

[0078] The compositions of the present disclosure may have a pH in the range of 3.0 to 8.0. According to embodiments, the pH may be in the range of 4.0 to 6.5, such as in the range of 4.5 to 6.0.

[0079] 5. Optional Cosmetically Acceptable Additives The compositions according to the present disclosure may optionally contain cosmetically acceptable additives, which may contribute to the achievement or enhancement of the desired properties or effects. According to embodiments, the cosmetically acceptable additives may be selected from fragrances, opacifiers, preservatives, pH adjusters, chelating agents, hair or skin care materials, physiologically compatible silicone derivative compounds, light protecting agents, anti-flaking agents, hair luster-imparting agents, combability improving agents, degreasing agents, moisturizers, conditioning agents, viscosity modifiers, and cooling agents. The cosmetically acceptable additives may be used in any combination as desired or required.

[0080] Suitable cosmetically acceptable additives not specifically listed below can be found in the International Cosmetics Ingredient Dictionary and Handbook (8th ed., The Cosmetics, Toiletry, and Fragrance Association). Volume 2, Chapters 3 (Chemical Classes) and 4 (Functions) are particularly useful in identifying specific additives to achieve specific or multiple purposes. Some of these additives are discussed below, although the disclosure is, of course, non-exhaustive.

[0081] The range of suitable amounts of fragrance, opacifier, preservative, pH adjuster, chelating agent, hair care material or skin care material, physiologically compatible silicone derivative compound, sunscreen, anti-stripping agent, hair gloss agent, combability improver, degreaser, moisturizing material, conditioning agent, viscosity adjuster, and cooling agent are shown for each additive discussed below. These cosmetically acceptable additives can be present in a total amount of up to 20.0 weight percent, particularly up to 15.0 weight percent, based on the weight of the composition. Typically, the total amount of these cosmetically acceptable additives can be in the range of 0.010 to 10.0 weight percent, conveniently 0.010 to 7.0 weight percent, based on the weight of the composition. For example, the total amount of these cosmetically acceptable additives can be in the range of 0.010 to 5.0 weight percent, conveniently 0.010 to 3.0 weight percent, based on the weight of the composition.

[0082] 5.1 Flavors or Fragrances The composition according to the present disclosure can include a fragrance or flavor. For example, the composition can include 0.0010 to 1.50 weight percent, particularly 0.010-0.50 weight percent, of the fragrance based on the weight of the composition. The fragrance can provide a richer user experience by making the composition smell pleasant and / or by evoking emotions, such as a relaxing or uplifting smell.

[0083] Alternatively, compositions according to the present disclosure can be substantially free of fragrances and / or fragrances. Some consumers prefer fragrance-free compositions.

[0084] The fragrance may be an animal fragrance or a botanical fragrance. The animal fragrance may be selected from the group consisting of musk oil, civet, castoreum, ambergris, and mixtures thereof.

[0085] The botanical fragrance may be selected from the group consisting of nutmeg extract, cardamom extract, ginger extract, cinnamon extract, patchouli oil, geranium oil, orange oil, mandarin oil, orange flower extract, cedarwood, vetiver, lavandin, ylang extract, tuberose extract, sandalwood oil, bergamot oil, rosemary oil, spearmint oil, peppermint oil, lemon oil, lavender oil, citronella oil, chamomille oil, clove oil, sage oil, neroli oil, labdanum oil, eucalyptus oil, verbena oil, mimosa extract, daffodil extract, carrot seed extract, jasmine extract, olibanum extract, rose extract, and mixtures thereof.

[0086] The fragrances are acetophenone, adoxal, aldehyde C-12, aldehyde C-14, aldehyde C-18, allyl caprylate, ambroxan, amyl acetate, dimethylindan derivatives, alpha-amyl cinnamic aldehyde, anethole, anisaldehyde, benzaldehyde, benzyl acetate, benzyl alcohol and ester derivatives, benzyl propionate, benzyl salicylate, borneol, butyl acetate, camphor, carbitol, cinnamaldehyde, cinnamyl acetate, cinnamyl alcohol, cis-3-hexanol and ester derivatives, cis-3-hexenyl methyl carbonate, citral, citronellol and ester derivatives, cumin aldehyde, cyclamen aldehyde, cyclogalbanate. galbanate), damascone, decalactone, decanol, estragole, dihydromyrcenol, dimethylbenzylcarbinol, 6,8-Dimethyl-2-nonanol, dimethylbenzylcarbinylbutyrate, ethyl acetate, ethyl isobutyrate, ethyl butyrate, ethyl propionate, ethyl caprylate, ethyl cinnamate, ethyl hexanoate, ethyl valerate, ethyl vanillin, eugenol, Exaltolide*, fenchone, fruity esters such as ethyl 2-methylbutyrate, galaxolide, geraniol and ester derivatives, helional, 2-heptonone, hexenol, alpha-hexylcinnamic aldehyde, hydroxycitrolnellal, indole, isoamyl acetate, isoeugenol acetate, ionone, isoeugenol, isoamyl isovalerate, iso E Super super), limonene, linalool, lilial, linalyl acetate, lyral, majantol, mayol, melonal, menthol, p-methylacetophenone, methyl anthranilate, methyl cedrylone cedrylone, methyl dihydrojasmonate, methyl eugenol, methyl ionone, methyl-α-naphthyl ketone, methylphenylcarbinyl acetate, mugetanol, γ-nonalactone, octanal, phenylethyl acetate, phenylacetaldehyde dimethyl acetate, phenoxyethyl isobutyrate, phenylethyl alcohol, pinene, sandalore, santalol, stemone, thymol, terpene, triplal, triethyl citrate, 3,3,5-trimethylcyclohexanol, γ-undecalactone, undecenal, vanillin, veloutone, verdox, and mixtures thereof.

[0087] 5.2 Opacifying or turbidity-inducing agents The composition according to the present disclosure may include an opacifying agent. The opacifying agent may also be referred to by the term "clouding agent". For example, the composition may include 0.10 to 5.0 weight percent, particularly 0.50 to 2.0 weight percent, of the opacifying agent based on the weight of the composition. Suitable opacifying agents include mineral pigments, such as titanium dioxide, alumina, calcium carbonate, and the like. Other suitable opacifying agents include fatty alcohols and fatty acid esters, such as cetearyl alcohol, cetyl alcohol, ethylene glycol distearate, glyceryl stearate, glyceryl oleate, stearyl stearate, and the like.

[0088] 5.3 Preservatives The composition according to the present disclosure can include a preservative or a mixture of preservatives. The composition can include a preservative in an amount of up to 1.0 weight percent, for example, 0.0010 to 1.0 weight percent, particularly 0.010 to 0.50 weight percent, based on the weight of the composition. Cosmetically acceptable preservatives include organic acids, such as parahydroxybenzoic acid; organic acid salts, such as sodium benzoate; compounds, such as benzyl alcohol, phenoxyethanol, 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione; and mixtures thereof.

[0089] 5.4 pH adjuster Compositions according to the present disclosure can include a pH adjusting agent and / or buffering agent in an amount sufficient to effectively modify the pH of the composition. For example, the present compositions can include up to 1.0 weight percent of a pH adjusting agent, such as from 0.000010 to 1.0 weight percent, particularly 0.0010 to 0.50 weight percent, based on the weight of the composition. Suitable pH adjusting and / or buffering agents for use in the present invention include, but are not limited to, ammonia, alkanolamines such as monoethanolamine, diethanolamine, triethanolamine, monopropanolamine, dipropanolamine, tripropanolamine, tripropanolamine, 2-amino-2-methyl-1-propanol and 2-amino-2-hydroxymethyl-1,3-propanediol and guanidinium salts, alkali metal and ammonium hydroxides and carbonates such as sodium hydroxide, sodium silicate, sodium metasilicate and ammonium carbonate, and acids such as organic and inorganic acids such as ascorbic acid, citric acid, acetic acid or tartaric acid, phosphoric acid, hydrochloric acid, and the like, and mixtures thereof.

[0090] Preferred alkaline pH adjusters include ammonia, ethanolamine and alkali metal hydroxides, especially sodium hydroxide. Preferred acidic pH adjusters include hydrochloric acid, ascorbic acid or citric acid.

[0091] 5.5 Chelating Agents The compositions according to the present disclosure may further comprise one or more chelating agents (also known as "chelating agents", "sequestering agents" or "sequestrants") in an amount sufficient to reduce the amount of metals that may interact with the formulation components. Chelating agents are well known in the art, and non-exhaustive lists can be found in AE Martell & RM Smith, Critical Stability Constants, Vol. 1, Plenum Press, New York & London (1974) and AE Martell & RD Hancock, Metal Complexes in Aqueous Solution, Plenum Press, New York & London (1996). Typically, the compositions may comprise one or more chelating agents in a total amount of 0.0010 to 1.0 weight percent, particularly 0.010 to 0.50 weight percent, based on the weight of the composition.

[0092] The one or more chelating agents can be selected from the group consisting of carboxylic acids (e.g., amino carboxylic acids), phosphonic acids (e.g., amino phosphonic acids), polyphosphoric acids (e.g., linear polyphosphoric acids), salts thereof, and mixtures thereof.

[0093] "Salts thereof" and "salts thereof," in the context of a chelating agent, mean all salts containing the same functional structure as the chelating agent, and refer to and include alkali metal salts, alkaline earth salts, ammonium salts, substituted ammonium salts, and mixtures thereof; or sodium salts, potassium salts, calcium salts, magnesium salts, ammonium salts, and mixtures thereof; or monoethanolammonium salts, diethanolammonium salts, triethanolammonium salts, and mixtures thereof.

[0094] The chelating agent(s) may be one or more aminocarboxylic acid chelating agents that contain one or more carboxylic acid moieties (-COOH) and one or more nitrogen atoms. The one or more aminocarboxylic acid chelators can be selected from the group consisting of diethylenetriaminepentaacetic acid (DTPA), ethylenediaminedisuccinic acid (EDDS), ethylenediamine-N,N'-diglutaric acid (EDDG), 2-hydroxypropylenediamine-N,N'-disuccinic acid (HPDDS), glycinamide-N,N'-disuccinic acid (GADS), ethylenediamine-N,N'-diglutaric acid (EDDG), 2-hydroxypropylenediamine-N,N'-disuccinic acid (HPDDS), ethylenediaminetetraacetic acid (EDTA), ethylenedicysteic acid (EDC), ethylenediamine-N,N'-bis(ortho-hydroxyphenylacetic acid) (EDDHA), diaminoalkyldi(sulfosuccinic acid) (DDS), N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid (HBED), salts thereof, and mixtures thereof. Conveniently, when used in compositions according to the present disclosure, the chelating agent may be EDTA.

[0095] 5.6 Viscosity or Rheology Modifiers The composition according to the present disclosure may include a viscosity modifier. Viscosity modifiers are also known in the art as "thickening agents". When present, such viscosity modifiers will typically be used in the composition in an amount of 0.010 to 3.0 weight percent, particularly 0.50 to 1.0 weight percent, based on the weight of the composition. Suitable cosmetically acceptable viscosity modifiers include non-ionic polymers, such as polysaccharides, such as cellulose, cellulose gum or xanthan gum, and non-ionic viscosity modifiers based on polyether-1, such as the commercially available viscosity modifier Pure Thix 1442.

[0096] 5.7 Further cosmetically acceptable additives The composition may further comprise a care material, such as a plant or vegetable extract providing hair care or providing skin care, a cationic polymer or a cationic surfactant, etc. Typical amounts of the care material in the composition according to the present disclosure will range from 0.010 to 5.0 weight percent, particularly 0.050-2.0 weight percent, based on the weight of the composition.

[0097] Additional cosmetically acceptable additives which may be present in compositions according to the present disclosure include: Physiologically compatible silicone derivative compounds, such as volatile or non-volatile silicones or high molecular weight siloxane polymers, such as Quaternium-80, typically in an amount of from 0.05 to 20 percent by weight, in particular from 0.10 to 5.0 percent by weight, based on the weight of the composition. Sunscreens, such as octyl methoxycinnamate Anti-stripping agents, typically used in amounts of about 0.01 to 2 percent by weight Hair gloss enhancers, such as phenyl trimethicone Combing agents, such as cationic surfactants, e.g. behentrimonium chloride, or cationic polymers, e.g. polyquaternium-10 Degreaser ·Conditioning agent Moisturizing agents, such as sodium lactate, sodium PCA, glycine, fructose, urea, niacinamide, inositol, etc. Coolants, such as menthol, eucalptol, geraniol, linalool, isopulegol, cubedol, p-mentane-3,8-diol, hydroxycitronellal, and their esters and derivatives; ketones, such as menthone and carvone; carboxamides, or evaporative coolants. Examples include:

[0098] Cosmetically acceptable additives can be used in any combination in compositions according to the present disclosure as desired or required.

[0099] 6 Substances that may be excluded Compositions according to the present disclosure can be substantially free or free of certain substances or classes of chemical compounds.

[0100] According to embodiments, the composition according to the present disclosure can be substantially free of biotin. According to embodiments, the composition according to the present disclosure can be free of biotin. According to certain embodiments, the concentration of biotin can be less than 5 ppm by weight.

[0101] According to embodiments, the composition according to the present disclosure can be substantially free of quaternary ammonium compounds. According to embodiments, the composition according to the present disclosure can be free of quaternary ammonium compounds. According to certain embodiments, the concentration of quaternary ammonium compounds can be less than 5 ppm by weight.

[0102] According to embodiments, the composition according to the present disclosure can be substantially free of silicone. According to embodiments, the composition according to the present disclosure can be free of silicone. According to some embodiments, the concentration of silicone can be less than 5 ppm by weight.

[0103] According to embodiments, the composition according to the present disclosure can be substantially free of quaternary ammonium compounds and silicone.According to embodiments, the composition according to the present disclosure can be substantially free of quaternary ammonium compounds and silicone.According to certain embodiments, the concentration of quaternary ammonium compounds and silicone can be less than 5 ppm by weight.

[0104] According to an embodiment, the polymeric compound that is exclusively present in the composition according to the present disclosure is a film-forming polymer. In other words, according to an embodiment, the composition according to the present disclosure can be substantially free of non-film-forming polymer. According to an embodiment, the composition according to the present disclosure can be free of non-film-forming polymer. According to some embodiments, the concentration of non-film-forming polymer can be less than 5 ppm by weight.

[0105] According to embodiments, compositions according to the present disclosure can be substantially free or free of non-film forming polymers selected from acrylates / steareth-20 methacrylate copolymers, carbomers, polyacrylamides, hydroxyethyl cellulose, xanthan gum, and polymers of similar chemistry.

[0106] According to embodiments, compositions according to the present disclosure can be substantially free or free of unsaturated fatty acids.

[0107] 7 Specific Compositional Embodiments Described below are embodiments of compositions according to the present disclosure that are formulated as liquid formulations or aerosols.

[0108] 7.1 Liquid Formulation Embodiments According to an embodiment, the composition according to the present disclosure can be formulated as a liquid formulation. The liquid formulation can have a conventional base for cosmetic compositions, such as an aqueous base, an alcoholic base or an aqueous-alcoholic base. The composition in the form of a liquid formulation can, for example, contain 70.0 to 99.5 weight percent of a water-alcoholic solvent (in addition to the active ingredient combination). In particular, the composition in the form of a liquid formulation can contain, for example, 90.0 to 99.0 weight percent, for example 92.0 to 98.0 weight percent, of a water-alcoholic solvent based on the weight of the composition.

[0109] The composition in the form of a liquid formulation can, for example, comprise water in an amount of at least 10 weight percent relative to the weight of the composition, and alcohol in an amount of at least 20 weight percent relative to the weight of the composition. The solvent can, for example, comprise a lower monohydric alcohol, such as ethanol, n-propanol and isopropanol, that is suitable for cosmetic purposes, or a polyhydric alcohol, such as glycerol, ethylene glycol, propylene glycol, or a combination thereof. The composition in the form of a liquid formulation can further comprise a solubilization enhancer, such as a non-ionic surfactant. The pH of the composition in the form of a liquid formulation can be within the range of 3 to 7, in particular within the range of 4 to 6.5, for example within the range of 4.5 to 6.

[0110] According to an embodiment, the composition in the form of a liquid formulation may be a hair tonic.

[0111] 7.2 Aerosol Formulation Embodiments According to an embodiment, the composition according to the present disclosure can be formulated as an aerosol formulation. The composition in the form of an aerosol formulation can comprise, for example, 70.0 to 99.5 weight percent, particularly 90.0 to 99.0 weight percent, for example 92.0 to 98.0 weight percent of a blend comprising starch particles and an alcohol-based solvent, based on the weight of the composition (in addition to the active ingredient combination).

[0112] The starch can be derived from any plant, such as potato, rice, maize or tapioca. According to an embodiment, the starch may be rice starch, tapioca starch or a combination thereof. The starch particles may be hydrophobically modified starch particles, non-hydrophobically modified starch particles or a combination thereof.

[0113] The alcohol-based solvent may include, for example, lower monohydric alcohols suitable for cosmetic purposes, such as ethanol, n-propanol, and isopropanol, or polyhydric alcohols, such as glycerol, ethylene glycol, propylene glycol, or combinations thereof. According to certain embodiments, the alcohol may be selected from ethanol and isopropanol.

[0114] The blend may further include a propellant such as propane, isobutane, n-butane, cyclopropane, or the like, or a combination thereof. Propane may include halogenated hydrocarbons, but is less preferred due to environmental concerns. The propellant is preferably one that is miscible with the alcohol-based solvent.

[0115] The blend of the composition in the form of an aerosol formulation can further include inorganic particles. Such inorganic particles act as dispersing agents to suspend any dispersed solid or liquid within the composition. The inclusion of inorganic particles in the aerosol composition can separate starch particles during settling when not in use, thereby preventing the formation of particle agglomerates that are difficult to break mechanically (by shaking). Suitable inorganic particles for the aerosol blend include silica, clay and mixtures thereof. For example, hydrophilic fumed silica particles with a total surface area of ​​more than 100 m2 / g are suitable inorganic particles for use in the aerosol blend.

[0116] According to an embodiment, the blend may comprise, by weight of the blend, 5.0 to 12.0 percent starch particles, 30.0 to 50.0 percent alcohol-based solvent, 40.0 to 60.0 percent propellant, and optionally 0.50 to 1.0 percent inorganic particles. According to a more specific embodiment, the blend may comprise, by weight of the blend, 7.0 to 10.0 percent starch particles, 33.0 to 38.0 percent alcohol-based solvent, 52.0 to 60.0 percent propellant, and optionally 0.60 to 0.90 percent inorganic particles.

[0117] According to an embodiment, the composition in the form of an aerosol formulation may be a dry shampoo.

[0118] 7.3 Scalp and hair treatment products According to an embodiment, the composition according to the present disclosure can be formulated as a ready-to-use scalp and hair treatment product. For example, the composition according to the present disclosure can be a ready-to-use scalp and hair treatment product selected from a hair tonic, a hair lotion, a hair conditioner, a hair cream, a hair shampoo, a dry shampoo, a hair rinse, a hair liquid, a hair oil, a hair pomade, a hair foam, and a hair spray.

[0119] According to a preferred embodiment, the composition according to the present disclosure is left on scalp after application for a sufficient time to cause the hair growth promoting or hair loss reducing effect of the active ingredient combination according to the present disclosure.For example, the composition can be left on scalp for at least 5 minutes, for example at least 15 minutes.The composition can be left on scalp for at least 30 minutes, for example at least 60 minutes.

[0120] According to a preferred embodiment, the ready-to-use scalp and hair treatment product is a leave-on product, which is a product that is applied to the hair and / or scalp and is not actively removed thereafter.

[0121] 8. Hair Tonic According to certain embodiments, the composition according to the present disclosure comprises: 0.90 to 1.20 weight percent of sandalpentanol; 0.90 to 1.20 percent by weight of caffeine; 0.10 to 0.25 weight percent of a C10 to C18 fatty acid or an alkali metal salt thereof, wherein the fatty acid is selected from lauric acid (C12:0), myristic acid (C14:0), or a combination thereof; 0.010 to 0.60 weight percent of a solubilization enhancer; 0.010 to 0.50 weight percent fragrance; 20.0 to 80.0 weight percent alcohol; 100% by weight water It is a hair tonic containing.

[0122] According to an embodiment, the C10-C18 fatty acid or its alkali metal salt can be lauric acid (C12:0) or sodium laurate. For example, the C10-C18 fatty acid can be lauric acid (C12:0) in the form of a free acid.

[0123] According to an embodiment, the solubilization enhancer of the hair tonic may be selected from PEGylated Castor Oil, hydrogenated PEG-ylated Castor Oil, or combinations thereof.

[0124] According to an embodiment, the alcohol of the hair tonic can be ethanol, or propanol, or a blend of ethanol and propanol. According to another embodiment, the alcohol of the hair tonic can be a blend of 70-50 parts by weight of ethanol and / or propanol and 30-50 parts by weight of ethylene glycol and / or propylene glycol.

[0125] According to an embodiment, the hair tonic may further comprise auxiliary ingredients. Examples of such auxiliary ingredients include, inter alia, vasodilators, blood circulation stimulants, antioxidants, vitamins, provitamins. The amount of auxiliary ingredients or combinations thereof, if present, will range from 0.0010 to 5.0 weight percent, in particular from 0.010 to 3.0 weight percent, based on the weight of the hair tonic.

[0126] Supplementary ingredients can include, for example, one or more of tocopherol, tocotrienol, tocopherol esters, nicotinic acid, nicotinamide, nicotinic acid esters, vasodilatory plant extracts, camphor, royal jelly, biotin, vitamin B3, vitamin B12, vitamin C, vitamin D2, vitamin D3, vitamin E, vitamin K1, vitamin K2, panthenol (provitamin B5), omega-3 fatty acids, omega-6 fatty acids, folate, cannabidiol, saw palmetto, minoxidil, or combinations thereof.

[0127] According to an embodiment, the auxiliary components include vasodilators selected from tocopherol (α-, β-, γ- or δ-tocopherol), especially α-tocopherol, tocopherol esters (examples include tocopherol acetate, tocopheryl succinate, tocopheryl nicotinate, tocopheryl poly(oxyethylene) succinate), nicotinic acid, nicotinamide, nicotinic acid esters, camphor; antioxidants, such as vitamin C or polyphenols; testosterone-5-α-reductase inhibitors, such as ω-6 fatty acid arachidonic acid; substances that benefit hair health, such as nicotinamide (niacinamide); or combinations thereof. According to an embodiment, the auxiliary components include tocopherol or tocopheryl acetate (vitamin E acetate) and / or niacinamide. Suitable vasodilatory plant extracts include burnt or distilled nettle extract (Urtica Diocia), roasted chestnut extract (Aesculus Hippocastanum) or arnica extract (Arnica Montana).

[0128] According to certain embodiments, the hair tonic may include supplemental ingredients selected from tocopherol, tocopherol esters, nicotinic acid, nicotinamide, vasodilatory plant extracts, camphor, royal jelly, vitamin B3, vitamin B12, vitamin C, vitamin D2, vitamin D3, vitamin E, cannabidiol, minoxidil, or combinations thereof.

[0129] According to an embodiment, the hair tonic may further comprise an oil component. The oil component may comprise, for example, peppermint oil, rosemary essential oil, lavender essential oil, tea tree oil, ylang ylang, thyme oil, cedarwood oil, clary sage essential oil, bergamot oil, jojoba oil, sunflower oil, hydrogenated olive ethylhexyl, or combinations thereof. If present, the oil component will be present in the hair tonic in an amount of 0.010 to 0.50 weight percent, particularly 0.025 to 0.25 weight percent, based on the weight of the hair tonic.

[0130] According to an embodiment, the oil component of the hair tonic can be further selected from peppermint oil, rosemary essential oil, thyme oil, cedarwood oil, bergamot oil, jojoba oil, hydrogenated ethylhexyl olive oil or combinations thereof.For example, the oil component of the hair tonic, when present, can include peppermint oil and / or hydrogenated ethylhexyl olive oil.

[0131] According to an embodiment, the hair tonic may further comprise a mineral component. If present, a preferred mineral component of the hair tonic is zinc, for example, in a concentration of 0.0050 to 0.50 molar.

[0132] According to an embodiment, the hair tonic may further comprise one or more cosmetically acceptable additives selected from fragrances, opacifiers, preservatives, pH adjusting agents, chelating agents, hair or skin care materials, physiologically compatible silicone derivative compounds, sunscreens, anti-stripping agents, hair gloss agents, combing agents, degreasing agents, moisturizing substances, conditioning agents, viscosity adjusting agents, cooling agents, or combinations thereof. The total amount of these cosmetically acceptable additives may be in the range of 0.010 to 5.0 weight percent, conveniently in the range of 0.010 to 3.0 weight percent, based on the weight of the hair tonic.

[0133] Examples of these cosmetically acceptable additives and their respective amount ranges are given above in chapter 5. According to an embodiment, the hair tonic may contain a moisturizing agent and / or a cooling agent. According to an embodiment, the moisturizing agent may be selected from niacinamide, sodium PCA, glycine. According to an embodiment, the cooling agent may be selected from menthol, menthyl lactate, isopulegol.

[0134] According to embodiments, the hair tonic can be substantially free of quaternary ammonium compounds, silicones, or combinations thereof. According to certain embodiments, the hair tonic can be substantially free of quaternary ammonium compounds, silicones, or combinations thereof.

[0135] According to embodiments, the hair tonic can be substantially free of biotin, unsaturated fatty acids, non-film forming polymers, or combinations thereof. In certain embodiments, the hair tonic can be substantially free of biotin, unsaturated fatty acids, non-film forming polymers, or combinations thereof.

[0136] For example, the hair tonic can be substantially free or free of quaternary ammonium compounds, silicones, biotin, unsaturated fatty acids, non-film forming polymers, or combinations thereof.

[0137] According to a particular embodiment, the hair tonic comprises: 0.90 to 1.20 weight percent of sandalpentanol; 0.90 to 1.20 percent by weight of caffeine; 0.10 to 0.25 weight percent lauric acid (C12:0); 0.010 to 0.50 weight percent fragrance; 0.10 to 0.50 weight percent PEG-40 hydrogenated castor oil; 0.010 to 0.10 weight percent PEG-35 castor oil; Optionally, 0.050 to 3.5 weight percent of nicotinic acid, nicotinamide, camphor, panthenol, or combinations thereof; Optionally, 0.00010 to 0.010 weight percent of a cosmetically acceptable antioxidant; and Optionally, up to 1.0 weight percent, e.g., 0.010 to 1.0 weight percent, of a pH adjuster, a preservative and / or a chelating agent; Optionally, 0.010 to 1.0 weight percent of a coolant; 40.0 to 65.0 weight percent of ethanol, or propanol, or a blend of ethanol and propanol, or a blend of 70 to 50 parts by weight of ethanol and / or propanol and 30 to 50 parts by weight of ethylene glycol and / or propylene glycol; 100% by weight water It essentially consists of:

[0138] According to a particular embodiment, the hair tonic comprises: 0.90 to 1.20 weight percent of sandalpentanol; 0.90 to 1.20 percent by weight of caffeine; 0.10 to 0.25 weight percent lauric acid (C12:0); 0.010 to 0.50 weight percent fragrance; 0.10 to 0.50 weight percent PEG-40 hydrogenated castor oil; 0.010 to 0.10 weight percent PEG-35 castor oil; Optionally, 0.050 to 3.5 weight percent of nicotinic acid, nicotinamide, camphor, panthenol, or combinations thereof; Optionally, 0.00010 to 0.010 weight percent of a cosmetically acceptable antioxidant; and Optionally, up to 1.0 weight percent, e.g., 0.010 to 1.0 weight percent, of a pH adjuster, a preservative and / or a chelating agent; Optionally, 0.010 to 1.0 weight percent of a coolant; 40.0 to 65.0 weight percent of ethanol, or propanol, or a blend of ethanol and propanol, or a blend of 70 to 50 parts by weight of ethanol and / or propanol and 30 to 50 parts by weight of ethylene glycol and / or propylene glycol; 100% by weight water It consists of:

[0139] According to a particular embodiment, the hair tonic comprises: 0.950 to 1.050 weight percent of sandalpentanol; 0.950 to 1.050 percent by weight of caffeine; 0.180 to 0.220 weight percent lauric acid (C12:0); 2.30 to 2.70 weight percent of nicotinic acid or nicotinamide; 0.10 to 0.40 weight percent fragrance; 0.10 to 0.250 weight percent PEG-40 hydrogenated castor oil; 0.030 to 0.060 weight percent PEG-35 castor oil; 0.00010 to 0.010 weight percent of an antioxidant selected from tocopherols, tocotrienols, and tocopheryl acetate; Optionally, up to 0.10 weight percent, e.g., 0.010 to 0.10 weight percent, of a pH adjuster, a preservative and / or a chelating agent; 50.0 to 55.0 weight percent of ethanol; 100% by weight water It essentially consists of:

[0140] According to a particular embodiment, the hair tonic comprises: 0.950 to 1.050 weight percent of sandalpentanol; 0.950 to 1.050 percent by weight of caffeine; 0.180 to 0.220 weight percent lauric acid (C12:0); 2.30 to 2.70 weight percent of nicotinic acid or nicotinamide; 0.10 to 0.40 weight percent fragrance; 0.10 to 0.250 weight percent PEG-40 hydrogenated castor oil; 0.030 to 0.060 weight percent PEG-35 castor oil; 0.00010 to 0.010 weight percent of an antioxidant selected from tocopherols, tocotrienols, and tocopheryl acetate; Optionally, up to 0.10 weight percent, e.g., 0.010 to 0.10 weight percent, of a pH adjuster, a preservative and / or a chelating agent; 50.0 to 55.0 weight percent of ethanol; 100% by weight water It consists of:

[0141] 9. Methods and Uses The composition or hair tonic according to the present disclosure can be used according to the method in which the composition or hair tonic is applied to the scalp. Conveniently, the composition or hair tonic can be applied to the scalp and then or at the same time allowed to soak in.

[0142] The composition or hair tonic according to the present disclosure is applied in an amount sufficient to obtain the desired effect. In particular, the composition or hair tonic can deliver an effective amount of the active ingredient combination by application to the scalp. For example, the composition or hair tonic can deliver a total of at least 0.25 g of sandalpentanol, caffeine, and C10-C18 fatty acids per day by application to the scalp. According to an embodiment, the composition or hair tonic can deliver a total of at least 0.50 g of sandalpentanol, caffeine, and C10-C18 fatty acids per day by application to the scalp. For example, the composition or hair tonic can deliver a total of at least 0.80 g of sandalpentanol, caffeine, and C10-C18 fatty acids per day by application to the scalp two or three times per day.

[0143] The composition or hair tonic according to the present disclosure is left on the scalp for a sufficient time to obtain the desired effect.In particular, the composition or hair tonic can be a leave-on product that is not rinsed or washed off, or at least not immediately, after application to the hair and / or scalp.

[0144] A further subject of the present disclosure is the use of the composition or hair tonic to promote the natural hair growth of a mammal and / or reduce hair loss in a mammal.According to an embodiment, the composition or hair tonic can be used to treat alopecia in a mammal, particularly in a human. EXAMPLES

[0145] The following examples are intended to more particularly illustrate the invention as claimed in the accompanying documents, and the details of these examples should not be construed as further limiting the scope of the claims appended hereto.

[0146] Example 1 Example 1 demonstrates the reduction in hair loss achieved by a composition according to the present invention using a Hair Pull Test. Table 1. Preparations TIFF0007629096000001.tif102170 Hair tensile test This test is based on the concept that telogen hairs will fall out if the hair is pulled "gently", and therefore allows a rough assessment of the rate of hair loss and a measurement of the resistance of the hair to pulling. This method allows a measurement of the percentage of hairs that are only loosely attached to the scalp, and the success of each of the active ingredient combinations or compositions in reducing hair loss. The ability to promote hair growth and / or inhibit or slow hair loss, respectively, will result in an increase in the number of hairs that cannot be pulled out in this test. The principle of the hair pull test consists of gently pulling approximately 60 hairs on three delineated scalp areas to score hair loss. Three areas of the scalp (front, vertex and back) are selected for hair that has not been washed for 2 days and has not been brushed or combed within 2 hours prior to testing. Approximately 60 strands of hair per area are pinched between the thumb and index finger and gently pulled. The hairs that come out as a result of the pulling are collected and counted. Hair pull tests will be performed by technicians at the research center at the following experimental times: At D1 / T0, before application of the product, After 8 weeks of continuous use of the product (D56), After 16 weeks of continuous product use (D112). Explanation of results All subjects enrolled in this study will be considered for hair pull test data as long as they have undergone the final examination at the specified time point. For each product, the following data was calculated: Means and standard deviations at D1 / T0, D56 and D112 time points, Fluctuation rate (%) of D56 against D1 / T0 and D112 against D1 / T0, Distribution of differences by Shapiro-Wilk test at 1% risk (D56-D1 / T0 and D112-D1 / T0). Significance is calculated according to the p-value of the paired two-tailed Student's "t" test if normality of distribution is observed, or the Wilcoxon test if this is not the case. A change was considered statistically significant if p<0.05. Table 2 shows Formulation 1 (Invented product: Sandalore 1%, Caffeine 1%, Lauric acid 0.2%) Formulation 2 (Comparison: 1% caffeine, 0.2% lauric acid, no Sandalore) Formulation 3 (comparison product: Sandalore 1% only) The results of the efficacy of each hair treatment using Table 2 Hair pulling test results The TIFF0007629096000002.tif82170 data show a statistically significant reduction in hair loss of up to 20.1% and 27.7% at 56 days (8 weeks) or 112 days (16 weeks) for the composition according to the invention (formulation 1). The composition without Sandalore (formulation 2) and the composition containing only 1% Sandalore (formulation 3) show significantly less efficacy. For formulation 2, the hair loss reduction rates of 17.2% after 56 days (8 weeks) and 21.6% after 112 days (8 weeks) of use, respectively, demonstrate a lower efficacy compared to formulation 1. For formulation 3, the reduction in alopecia (-17.1%) is still lower after 84 days (12 weeks) of application, when compared to the composition according to the invention.

[0147] Example 2 Example 2 demonstrates the hair growth achieved by a composition according to the invention, as determined by the prolongation of the anagen phase in an ex vivo skin treatment.

[0148] Human full-thickness scalp skin punches (6 mm diameter) with hair attached were obtained from the occipital region of a 34-year-old female donor. Human punches were sectioned and cultured at 37°C and 5% CO2 in William's Complete Media (WCM) modified from William's E minimal medium (Gibco, Life Technologies) supplemented with 10 ng / ml hydrocortisone (Sigma Aldrich), 10 μg / ml insulin (Sigma Aldrich), and 1% penicillin / streptomycin (Gibco) as previously described (Edelkamp et al., Molecular Dermatology 2020; Langan et al., Exp Dermatol 2015). Cultures were left undisturbed for 24 hours (day 0) before topical treatments were performed twice (days 1 and 3). Medium was changed on day 3. Punched pieces were embedded in OCT compound (Optimal Cutting Temperature Compound) and cryosectioned (7 μm sections) at 5 days of ex vivo culture (day 5). Experimental groups for local treatments are outlined in Table 3. Table 3 Experimental groups TIFF0007629096000003.tif42170

[0149] Hair cycle staging and hair cycle scoring can be performed at the end of the culture and determined according to several established macroscopic and microscopic paremeters (Langan et al., Exp Dermatol 2015; Oh et al., JID 2016).

[0150] Hair cycle staging was assessed microscopically using Masson-Fontana histochemistry and Ki-67 / TUNEL immunostaining as previously described (Kloepper et al., Exp Dermatol 2010; Langan et al., Exp Dermatol 2015). The percentage of follicles in each phase of the hair cycle was calculated for each experimental group and is shown below. Table 4. Microscopic hair cycle staging TIFF0007629096000004.tif59170Table 5 Hair cycle score (fewer hairs means more hairs in anagen / growth phase) TIFF0007629096000005.tif59170

[0151] The data in Tables 4 and 5 demonstrate that topical application of Sandalore to ex vivo cultured scalp prolongs anagen. Co-treatment with caffeine and lauric acid further enhances this effect.

Claims

1. A composition comprising sandalpentanol, caffeine, one or more saturated and / or unsaturated C10-C18 fatty acids, and a solvent, wherein sandalpentanol is present in an amount of from 0.50 to 2.0 weight percent, caffeine is present in an amount of from 0.50 to 2.0 weight percent, and one or more C10-C18 fatty acids are present in an amount of from 0.10 to 2.0 weight percent, each based on the weight of the composition.

2. 2. The composition of claim 1, wherein the C10-C18 fatty acids are selected from capric acid (C10:0), lauric acid (C12:0), myristic acid (C14:0), isomyristic acid (C14:0), palmitic acid (C16:0), palmitoleic acid (C16:1), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), linolenic acid (C18:3), parinaric acid (C18:4), petroselinic acid (C18:1), or combinations thereof.

3. 3. The composition of claim 1 or 2, wherein the C10-C18 fatty acids include lauric acid (C12:0), myristic acid (C14:0), or a combination thereof.

4. 4. The composition of any one of claims 1 to 3, wherein the C10-C18 fatty acids comprise palmitoleic acid (C16:1), oleic acid (C18:1), linoleic acid (C18:2), linolenic acid (C18:3), parinaric acid (C18:4), petroselinic acid (C18:1), or combinations thereof.

5. 4. The composition of any one of claims 1 to 3, wherein the composition is substantially free of unsaturated C10 to C18 fatty acids.

6. 6. The composition of any one of claims 1 to 5, wherein the C10 to C18 fatty acid is present in the form of a free acid, an alkali metal salt, an alkaline earth metal salt, an ammonium salt, or a combination thereof.

7. A composition described in any one of claims 1 to 6, wherein the fatty acid is present in the form of a free acid.

8. 8. The composition of any one of claims 1 to 7, wherein sandalpentanol is present in an amount from 0.80 to 1.50 weight percent, caffeine is present in an amount from 0.80 to 1.50 weight percent, and one or more C10-C18 fatty acids are present in an amount from 0.10 to 1.0 weight percent, each based on the weight of the composition.

9. A composition according to any one of claims 1 to 8, further comprising an auxiliary component selected from vasodilators, blood circulation stimulants, antioxidants, vitamins, provitamins and combinations thereof.

10. 10. The composition of claim 9, wherein the adjunct component is present in an amount of from 0.0010 to 5.0 weight percent based on the weight of the composition.

11. A composition described in claim 9 or 10, wherein the auxiliary component is present in an amount of from 0.010 to 3.0 weight percent based on the weight of the composition.

12. 12. The composition of any one of claims 9 to 11, wherein the supplemental ingredients include one or more of tocopherol, tocotrienol, tocopherol esters, nicotinic acid, nicotinamide, nicotinic acid esters, vasodilatory plant extracts, camphor, royal jelly, biotin, vitamin B3, vitamin B12, vitamin C, vitamin D2, vitamin D3, vitamin E, vitamin K1, vitamin K2, panthenol, omega-3 fatty acids, omega-6 fatty acids, folate, cannabidiol, saw palmetto, minoxidil, or combinations thereof.

13. 13. The composition of any one of claims 1 to 12, further comprising an oil component selected from peppermint oil, rosemary essential oil, lavender essential oil, tea tree oil, ylang ylang, thyme oil, cedarwood oil, clary sage essential oil, bergamot oil, jojoba oil, sunflower oil, hydrogenated ethylhexyl olive oil, or combinations thereof.

14. 14. The composition of claim 13, wherein the oil component is present in an amount of from 0.0010 to 1.0 weight percent, based on the weight of the composition.

15. A composition described in claim 13 or 14, wherein the oil component is present in an amount of from 0.010 to 0.50 weight percent based on the weight of the composition.

16. 16. The composition of any one of claims 1 to 15, further comprising a mineral component selected from iron, zinc, or a combination thereof.

17. 17. The composition of claim 16, wherein the mineral component is present in a concentration of 0.0050 to 0.50 molar.

18. The composition of any one of claims 1 to 17, wherein the solvent is water-based, alcohol-based or water-alcohol-based.

19. 19. The composition of any one of claims 1 to 18, wherein the solvent comprises water and an alcohol selected from ethanol, propanol, glycerol, ethylene glycol, propylene glycol, or combinations thereof.

20. 20. The composition of any one of claims 1 to 19, further comprising a solubilization enhancer.

21. 21. The composition of claim 20, wherein the solubilization enhancer comprises one or more surfactants.

22. 22. The composition of any one of claims 1 to 21, having a pH in the range of from 3.0 to 8.

0.

23. The composition of any one of claims 1 to 22, having a pH within the range of 4.0 to 6.

5.

24. The composition of any one of claims 1 to 23, having a pH within the range of 4.5 to 6.

0.

25. 25. The composition of any one of claims 1 to 24, further comprising one or more cosmetically acceptable additives selected from fragrances, opacifying agents, preservatives, pH adjusting agents, chelating agents, hair care or skin care materials, physiologically compatible silicone derivative compounds, light screening agents, anti-flaking agents, hair gloss agents, combability enhancers, degreasing agents, moisturizing materials, conditioning agents, viscosity modifiers, cooling agents, or combinations thereof.

26. 26. The composition of any one of claims 1 to 25, wherein the composition is substantially free of biotin.

27. 27. The composition of any one of claims 1 to 26, wherein the composition is substantially free of quaternary ammonium compounds.

28. 28. The composition of any one of claims 1 to 27, wherein the composition is substantially free of silicone.

29. 29. The composition of any one of claims 1 to 28, wherein the composition is substantially free of non-film-forming polymers.

30. 30. The composition of claim 29, wherein the composition is substantially free of acrylates / steareth-20 methacrylate copolymer, carbomer, polyacrylamide, hydroxyethyl cellulose, and xanthan gum.

31. 31. The composition of any one of claims 1 to 30, comprising from 70.0 to 99.5 weight percent of the water-alcohol based solvent, based on the weight of the composition.

32. The composition of claim 1, comprising from 90.0 to 99.0 weight percent of a water-alcohol-based solvent based on the weight of the composition.

33. The composition of any one of claims 1 to 32, comprising from 92.0 to 98.0 weight percent of a water-alcohol based solvent based on the weight of the composition.

34. 34. The composition of any one of claims 31 to 33, comprising water in an amount of at least 10 weight percent, based on the weight of the composition, and alcohol in an amount of at least 20 weight percent, based on the weight of the composition.

35. 35. The composition of any one of claims 31 to 34, wherein the solvent comprises an alcohol selected from ethanol, n-propanol, isopropanol, glycerol, ethylene glycol, propylene glycol, or combinations thereof.

36. 36. The composition according to any one of claims 31 to 35, wherein the composition is a hair tonic.

37. 31. The composition of any one of claims 1 to 30, comprising from 70.0 to 99.5 weight percent of a blend comprising starch particles and an alcohol-based solvent, based on the weight of the composition.

38. The composition of any one of claims 1 to 30, comprising a blend comprising starch particles and an alcohol-based solvent in an amount of 90.0 to 99.0 weight percent based on the weight of the composition.

39. A composition described in any one of claims 1 to 30, comprising a blend comprising starch particles and an alcohol-based solvent in an amount of 92.0 to 98.0 weight percent based on the weight of the composition.

40. 40. The composition of any one of claims 37 to 39, wherein the blend further comprises a propellant.

41. 41. The composition of any one of claims 37 to 40, wherein the blend further comprises inorganic particles.

42. 42. The composition of any one of claims 37 to 41, wherein the blend comprises from 5.0 to 12.0 weight percent starch particles, from 30.0 to 50.0 weight percent alcohol-based solvent, and from 40.0 to 60.0 weight percent propellant, based on the weight of the blend.

43. The composition of claim 42, wherein the blend further comprises 0.50 to 1.0 weight percent inorganic particles based on the weight of the blend.

44. 44. The composition of any one of claims 37 to 43, wherein the blend comprises 7.0 to 10.0 weight percent starch particles, 33.0 to 38.0 weight percent alcohol-based solvent, and 52.0 to 60.0 weight percent propellant, based on the weight of the blend.

45. The composition of claim 44, wherein the blend further comprises 0.60 to 0.90 weight percent inorganic particles based on the weight of the blend.

46. 44. The composition of any one of claims 37 to 43, wherein the composition is a dry shampoo.

47. 31. The composition of any one of claims 1 to 30, wherein the composition is a ready-to-use scalp and hair treatment product selected from a hair tonic, a hair lotion, a hair conditioner, a hair cream, a hair shampoo, a dry shampoo, a hair rinse, a hair liquid, a hair oil, a hair pomade, a hair foam, and a hair spray.

48. 48. The composition of claim 47, wherein the product is a leave-on product.

49. 0.90 to 1.20 weight percent of sandalpentanol; 0.90 to 1.20 weight percent caffeine; 0.10 to 0.25 percent by weight of a C10 to C18 fatty acid or an alkali metal salt thereof, wherein the fatty acid is selected from lauric acid (C12:0), myristic acid (C14:0), or a combination thereof; 0.010 to 0.60 weight percent of a solubilization enhancer; 0.010 to 0.50 weight percent of a fragrance; 20.0 to 80.0 weight percent alcohol; The remaining water A hair tonic containing

50. 50. A hair tonic according to claim 49, in which the C10 to C18 fatty acid or an alkali metal salt thereof is lauric acid (C12:0) or sodium laurate.

51. 51. A hair tonic according to claim 49 or 50, wherein the solubilisation enhancer is selected from PEGylated castor oil, PEGylated hydrogenated castor oil or combinations thereof.

52. 52. A hair tonic according to any one of claims 49 to 51, wherein the alcohol is ethanol or propanol or a blend of ethanol and propanol.

53. A hair tonic according to any one of claims 49 to 51 in which the alcohol is a blend of 70 to 50 parts by weight of ethanol and / or propanol and 30 to 50 parts by weight of ethylene glycol and / or propylene glycol.

54. 54. The hair tonic of any one of claims 49 to 53, further comprising 0.050 to 3.50 weight percent of adjunct ingredients comprising one or more of the following, or combinations thereof: tocopherol, tocotrienol, tocopherol esters, nicotinic acid, nicotinamide, nicotinic acid esters, vasodilatory plant extracts, camphor, royal jelly, biotin, vitamin B3, vitamin B12, vitamin C, vitamin D2, vitamin D3, vitamin E, vitamin K1, vitamin K2, panthenol, omega-3 fatty acids, omega-6 fatty acids, folate, cannabidiol, saw palmetto, minoxidil.

55. 55. The hair tonic of claim 54, wherein the auxiliary ingredients are selected from tocopherol, tocopherol esters, nicotinic acid, nicotinamide, vasodilatory plant extracts, camphor, royal jelly, vitamin B3, vitamin B12, vitamin C, vitamin D2, vitamin D3, vitamin E, cannabidiol, minoxidil, or combinations thereof.

56. 56. The hair tonic of any one of claims 49 to 55, further comprising 0.025 to 0.25 weight percent of an oil component selected from peppermint oil, rosemary essential oil, lavender essential oil, tea tree oil, ylang ylang, thyme oil, cedarwood oil, clary sage essential oil, bergamot oil, jojoba oil, sunflower oil, hydrogenated ethylhexyl olive oil, or combinations thereof.

57. 57. The hair tonic of claim 56, wherein the oil component is selected from peppermint oil, rosemary essential oil, thyme oil, cedarwood oil, bergamot oil, jojoba oil, hydrogenated ethylhexyl olive oil, or combinations thereof.

58. 58. A hair tonic according to any one of claims 49 to 57 further comprising zinc in a molar concentration of from 0.0050 to 0.

50.

59. 59. The hair tonic of any one of claims 49 to 58, further comprising 0.010 to 5.0 weight percent of one or more cosmetically acceptable additives selected from fragrances, opacifying agents, preservatives, pH adjusting agents, chelating agents, hair care or skin care materials, physiologically compatible silicone derivative compounds, light blocking agents, anti-flaking agents, hair gloss imparting agents, combability enhancers, degreasing agents, moisturizing substances, conditioning agents, viscosity modifiers, cooling agents, or combinations thereof.

60. 60. A hair tonic according to claim 59, comprising a moisturising substance and / or a cooling agent.

61. 61. The hair tonic of any one of claims 49 to 60, wherein the hair tonic is substantially free of quaternary ammonium compounds, silicones, or combinations thereof.

62. 0.90 to 1.20 weight percent of sandalpentanol; 0.90 to 1.20 weight percent caffeine; 0.10 to 0.25 weight percent lauric acid (C12:0); 0.010 to 0.50 weight percent of a fragrance; 0.10 to 0.50 weight percent PEG-40 hydrogenated castor oil; 0.010 to 0.10 weight percent PEG-35 castor oil; 40.0 to 65.0 weight percent of ethanol or propanol, or a blend of ethanol and propanol, or a blend of 70 to 50 parts by weight of ethanol and / or propanol and 30 to 50 parts by weight of ethylene glycol and / or propylene glycol; The remaining water A hair tonic consisting essentially of:

63. 0.050 to 3.5 weight percent of nicotinic acid, nicotinamide, camphor, panthenol, or a combination thereof; 0.00010 to 0.010 weight percent of a cosmetically acceptable antioxidant; up to 1.0 weight percent of a pH adjuster, a preservative and / or a chelating agent; and Coolant 0.010 to 1.0 weight percent 63. The hair tonic of claim 62, further comprising one or more of:

64. 0.950 to 1.050 weight percent of sandalpentanol; 0.950 to 1.050 weight percent caffeine; 0.180 to 0.220 weight percent lauric acid (C12:0); 2.30 to 2.70 weight percent nicotinic acid or nicotinic acid amide; 0.10 to 0.40 weight percent fragrance; 0.10 to 0.250 weight percent PEG-40 hydrogenated castor oil; 0.030 to 0.060 weight percent PEG-35 castor oil; 0.00010 to 0.010 weight percent of an antioxidant selected from tocopherols, tocotrienols, and tocopheryl acetate; 50.0 to 55.0 weight percent ethanol; The remaining water A hair tonic consisting essentially of:

65. A hair tonic as described in claim 64, further comprising up to 0.10 weight percent of a pH adjuster, a preservative and / or a chelating agent.

66. 66. A composition as claimed in any one of claims 1 to 48 or a hair tonic as claimed in any one of claims 49 to 65 for use in the treatment of alopecia in a mammal.

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