Cryoablation needle with adjustable vacuum wall position

Abstract

The present invention discloses a cryoablation needle with an adjustable vacuum wall position, comprising a vacuum wall, a JT slot and a vacuum wall adjustment device, wherein the vacuum wall comprises a needle bar and an inner tube, a distal end of the needle bar has a needle tip, the inner tube is drilled into the needle bar, a sandwich is formed between the inner tube and the needle bar, the distal end of the inner tube has a first predetermined distance between it and the distal end of the needle bar, the JT slot is drilled into the inner tube, and the distal end of the vacuum wall is switched between at least two adjustment positions with respect to the JT slot, the two adjustment positions include a first adjustment position and a second adjustment position, among the regions distributed along the axial direction of the vacuum wall, the region where the sandwich is located is a vacuum insulation region, and the region where the first predetermined distance is located is a target region, and when the needle tip is in the first adjustment position, the distal end of the JT slot is located in the vacuum insulation region. The present invention significantly accelerates the cooling rate by switching the distal end of the vacuum wall between at least two adjustable positions.

Description

[Technical field]

[0001] The present invention relates to the technical field of cryoablation, and in particular to a cryoablation needle with an adjustable vacuum wall position. [Background technology]

[0002] Cryoablation is a treatment that destroys diseased tissue by low temperature and is considered to be a highly effective and minimally invasive treatment for malignant tumors. Cryoablation technology is not only easy to operate, has few complications, and has a high analgesic effect, but also allows for the safe ablation of lesions close to large blood vessels and vital organs because the boundaries of the ice ball formed for ablation are clear and easy to observe. In addition, cryoablation can take the form of multi-needle freezing, which allows for ablation of a larger area and is suitable for large lesions or lesions with irregular shapes.

[0003] During cell freezing, ice crystals are first formed outside the cells, which causes an increase in the concentration of extracellular solutes, resulting in a hypertonic environment, and intracellular water enters the outside of the cells, causing intracellular dehydration. The cells that have lost moisture become wrinkled, the cell membrane is deformed, and cause "solution damage" in a highly toxic environment. At the same time, the ice crystals formed inside the cells directly damage the cell organelles and cell membranes, causing further necrosis, which is generally called "intracellular ice damage", and intracellular ice damage directly damages the cell structure, so the destructive force on the cells is more powerful. In general, the slower the cooling rate of the cells, the higher the probability of "solution damage" occurring, and the faster the cooling rate, the easier it is to induce "intracellular ice damage". Therefore, in tumor cryoablation surgery, a faster cooling rate is generally required, which can kill the tumor more thoroughly and save a lot of treatment time.

[0004] The development of cryoablation technology has gone through three stages. The first stage is the liquid nitrogen transport freezing technology, which uses low driving pressure to deliver liquid nitrogen at -196°C to the tip of the cryoablation needle to achieve the purpose of cryoablation. The cold source in this technology relies entirely on liquid nitrogen, but the liquid nitrogen is stored in the main engine or liquid nitrogen tank, which is transported a long distance from the needle tip. During the process of transporting liquid nitrogen, the temperature of the needle tip does not reach -196°C until the entire transport pipeline reaches -196°C, so the cooling speed of liquid nitrogen freezing is the slowest of existing technologies. The second stage is the direct squeeze-freezing technology, which utilizes the principle of the Joule Thomson effect (JT), transporting room temperature ultra-high pressure gas to the JT slot (a capillary that generates the JT effect) in the cryoablation needle to perform the direct squeeze process and reduce the temperature. The cooling speed is relatively the fastest among existing technologies, but the structure of the needle, such as the JT slot and fin tube, still consumes some of the cold air, which makes the cooling time longer. In addition, the ultra-high pressure gas used is not widely used and is expensive, making it difficult to popularize this technology. The third stage is the squeeze-freezing technology with pre-cooling, which is based on the principle that general industrial gas at room temperature is pre-cooled by the related main machine, then transported to the JT slot in the cryoablation needle to perform the squeeze process and reduce the ablation temperature to a lower temperature than the pre-cooling temperature. This technology solves the problem that the gas source is expensive and rare. By combining with squeeze-freezing technology, the cooling speed is much faster than liquid nitrogen freezing technology, but compared with direct squeeze-freezing technology, the cooling speed is still slow. Summary of the Invention [Problem to be solved by the invention]

[0005] In order to address the above-mentioned problems of the prior art and solve the problem of the slow cooling rate of the prior art, the present invention proposes a cryoablation needle with an adjustable vacuum wall position.

[0006] In order to solve the above technical problems, the present invention is realized by the following technical solutions.

[0007] The present invention provides a cryoablation needle with adjustable vacuum wall position, comprising a vacuum wall, a JT slot and a vacuum wall adjustment device, wherein: the vacuum wall includes a needle bar and an inner tube; the distal end of the needle bar has a needle tip; the inner tube is inserted into the needle bar, and a sandwich is formed between the inner tube and the needle bar, and the sandwich is capable of forming a vacuum; a distal end of the inner tube has a first predetermined distance from a distal end of the needle bar along an axial direction of the vacuum wall, the distal end of the inner tube being an end of the inner tube close to the needle tip; The JT slot is drilled in the inner tube, the needle tip is switchable between at least two adjustment positions with respect to the JT slot, the at least two adjustment positions including a first adjustment position and a second adjustment position; Among the regions distributed along the axial direction of the vacuum wall, the region in which the sandwich is located is a vacuum insulation region, and the region in which the first predetermined distance is located is a target region; when the needle tip is in a first adjustment position, a distal end of the JT slot is located within the target area, and the distal end of the JT slot is an end of the JT slot proximal to the needle tip; When the needle tip is in a second adjustment position, a distal end of the JT slot is located within the vacuum insulation region; the vacuum wall adjustment device is used to adjust the position of the needle tip, thereby switching the needle tip between the at least two adjustment positions; When the distal end of the JT slot is in the first adjustment position, the distal end of the JT slot has a second predetermined distance along the axial direction of the vacuum wall between the distal end of the JT slot and the needle tip, and the second predetermined distance at least ensures that an ice ball formed by freezing covers the needle tip, i.e., the refrigerant fluid returns from the inside of the target area and the inside of the vacuum insulation area after being discharged from the JT slot, where the refrigerant fluid exchanges heat with a material outside the entire target area while returning from the inside of the target area; When the distal end of the JT slot is in the second adjustment position, the distal end of the JT slot has a third predetermined distance along the axial direction of the vacuum wall between the distal end of the vacuum insulation region, the third predetermined distance at least ensures that the refrigerant returns directly from within the vacuum insulation region after being discharged from the JT slot, and there is only a relatively static refrigerant in the target region and no heat exchange with materials outside the target region, i.e., the refrigerant does not release any cold air in the target region during freezing. The distal end of the vacuum insulation region is the end of the vacuum insulation region near the needle tip.

[0008] Preferably, the vacuum wall adjustment device includes a first slider and a first slider guide, The first slider guide portion is provided along an axial direction of the vacuum wall, the first slider is connected to the vacuum wall, and a position of the first slider guide portion relative to the first slider or the JT slot is constant; wherein, when a position of the first slider guide portion relative to the first slider is constant, the first slider guide portion and the JT slot are relatively slidable, and when a position of the first slider guide portion relative to the JT slot is constant, the first slider and the first slider guide portion are relatively slidable, The first slider and the vacuum wall are controllable to move synchronously along the axial direction, thereby switching the adjustment position of the needle tip.

[0009] Preferably, the needle further comprises a first seal assembly, the first seal assembly being in sealing connection with a proximal end of the inner tube, the proximal end of the inner tube being an end of the inner tube remote from the needle tip; A dynamic seal is provided between the first seal assembly and the first slider.

[0010] Preferably, the first seal assembly includes a seal ring, a seal groove and a seal pressing member, wherein: a distal end of the seal groove fixedly sealed to a proximal end of the inner tube, the distal end of the seal groove being an end of the seal groove proximal to the needle tip; The seal ring is provided between the seal pressing member and a first slider, and the seal pressing member is provided between the seal ring and a seal groove, The seal ring and the seal pressing member are slidably connected to the seal groove, The first slider, the seal ring and the seal pressing member are controllable so as to move synchronously along the axial direction.

[0011] Preferably, the spring and snap member further comprises: one end of the spring moves synchronously with the distal end of the JT slot and is also connected to the snap member, the snap member being capable of moving into and out of a snap position; The other end of the spring is fixed relative to the JT slot. When the snap member is in the snap position, the spring is held in a deformed state by the restriction of the snap member and the distal end of the vacuum wall is in the second adjustment position; The deformation state is a compression state or an extension state, When the snap member is released from the snap position, the spring can generate a restoring force to return from the deformed state to its natural state, and the restoring force can drive the distal end of the vacuum wall to advance from the second adjustment position to the first adjustment position.

[0012] Preferably, the device further includes a first lever, the first lever including a front lever and a rear lever, the front lever is fixedly connected to the vacuum wall; a distal end of the rear lever is inserted into a proximal end of the front lever, and the two are slidable relative to each other; The front lever and / or the rear lever are provided with a limit ring, which is used to limit the farthest distance the vacuum wall can move distally.

[0013] Preferably, the snap member comprises a gripper and a C-ring, wherein: The gripping portion is provided on the C-shaped ring, The C-ring is covered by the outer wall of the rear lever.

[0014] Preferably, the vacuum wall includes a front vacuum wall and a rear vacuum wall, the front vacuum wall and the rear vacuum wall are sequentially distributed from the distal end to the proximal end of the vacuum wall, the front vacuum wall and the rear vacuum wall are relatively movable, and the needle tip is located at the front vacuum wall; The vacuum wall adjustment device adjusts the relative position of the front vacuum wall and the rear vacuum wall to switch the needle tip between the at least two adjustment positions.

[0015] Preferably, the vacuum wall adjustment device includes a second slider and a second slider guide, The second slider guide portion is provided along an axial direction of the vacuum wall, the second slider is connected to the front vacuum wall, and a position of the second slider guide portion relative to the front vacuum wall or the rear vacuum wall is constant; Here, when the position of the second slider guide portion relative to the rear vacuum wall is constant, the second slider and the second slider guide portion are capable of sliding relative to each other, and when the position of the second slider guide portion relative to the front vacuum wall is constant, the rear vacuum wall and the second slider guide portion are capable of sliding relative to each other.

[0016] The second slider and the front vacuum wall are controllable to move synchronously along the axial direction, thereby switching the adjustment position of the needle tip.

[0017] Preferably, the vacuum chamber further includes a second seal assembly disposed between the front and rear vacuum walls and used to form a dynamic seal between the front and rear vacuum walls.

[0018] Preferably, the device further includes a toggle and a second lever, the second lever including a lever adjustment slot; The toggle is connected to the slider, the toggle is disposed within the lever adjustment slot, and the toggle protrudes from an outer wall of the second lever; the toggle is slidably connected to the lever adjustment slot; The toggle and the second slider are controllable to move synchronously along the axis.

[0019] Preferably, the vacuum wall further comprises an outer tube and a gasket, wherein: a distal end of the outer tube is sealingly connected to a proximal end of the needle rod, a proximal end of the outer tube is sealingly connected to a proximal end of the inner tube, the distal end of the outer tube being an end of the outer tube close to the needle tip, and the proximal end of the outer tube being an end of the outer tube away from the needle tip; the gasket is disposed between an outer wall of the inner tube and an inner wall of the needle bar to form a sealed connection; From the distal end to the proximal end of the inner tube, the inner tube includes, in order, an inner tube front section and an inner tube rear section; The front portion of the inner tube is formed in the needle bar, and the rear portion of the inner tube is formed in the outer tube, When the vacuum wall includes a front vacuum wall and a rear vacuum wall, the front vacuum wall includes the needle bar and the front section of the inner tube, and the rear vacuum wall includes the outer tube and the rear section of the inner tube.

[0020] Preferably, an outer diameter of the outer tube is larger than an outer diameter of the needle bar, and an inner diameter of the outer tube is larger than an inner diameter of the needle bar, The outer diameter of the rear section of the inner tube is larger than the outer diameter of the front section of the inner tube, and the inner diameter of the rear section of the inner tube is larger than the inner diameter of the front section of the inner tube.

[0021] Preferably, the device further comprises a temperature measurement line; a distal end of the temperature measuring line is a temperature measuring point, the distal end of the temperature measuring line being an end of the temperature measuring line proximal to the needle tip; The temperature measurement point is provided at the distal end of the JT slot and is used to measure the temperature at the distal end of the JT slot.

[0022] Compared with the prior art, the present invention has the following advantages:

[0023] (1) In the cryoablation needle with adjustable vacuum wall position provided by the present invention, the distal end position of the vacuum wall is adjustable, including at least two adjustable positions; by activating the freezing after the JT slot is retracted into the vacuum insulation area, all the transport pipelines on the main machine side and the cryoablation needle side can be pre-purged (cooled); and since this pre-purge process does not consume any cold air in the target area, all the cold air is used to cool the transport pipelines, so that the cooling process of the transport pipelines is the fastest; furthermore, since no cold air is released in the target area during pre-purge, no frost or ice will occur in the target area, and the formal treatment can be directly carried out.

[0024] (2) In the cryoablation needle with adjustable vacuum wall position provided by the present invention, the position of the distal end of the vacuum wall is adjustable, including at least two adjustable positions, and the cryoablation needle after pre-purging is not only cooled at the target area of ​​the vacuum wall, but also after the JT slot is retracted inside the target area, all the heat load is only on the target area and the tumor tissue outside it, so that the cooling rate of this freezing process is greatly accelerated.

[0025] (3) In the cryoablation needle with adjustable vacuum wall position provided by the present invention, after the tool test process is completed, the pre-purge mode can be kept on and the inside of the vacuum insulation area (the distal end of the JT slot) can be kept at the lowest temperature, and no cold air is released into the target area, so that operations such as puncturing, scanning, positioning, etc. can be performed. After being punctured into the specified position, the cryoablation needle can be adjusted to the freezing mode, at which point the inside of the target area is directly and instantly cooled from normal temperature to the lowest temperature, which enables extreme and rapid cooling during the formal treatment.

[0026] (4) The cryoablation needle with adjustable vacuum wall position provided by the present invention has a wide range of applications and can be applied to all existing cryoablation techniques, such as liquid nitrogen transport freezing technology, direct squeeze freezing technology, and squeeze freezing technology via pre-cooling, and is applicable not only to percutaneous puncture cryoablation instruments but also to cryoablation instruments for transnatural orifice procedures.

[0027] Of course, any given product embodying the present invention need not necessarily achieve all of the above advantages simultaneously. [Brief description of the drawings]

[0028] In order to more clearly describe the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces drawings used in the description of the embodiments or the prior art. It should be understood that the drawings in the following description are only some embodiments of the present invention, and those skilled in the art can derive other drawings based on these drawings without any creative efforts.

[0029] [Figure 1] 1 is a diagram showing the adjustment principle of the vacuum wall of a rigid cryoablation needle with adjustable vacuum wall position according to one embodiment of the present invention; FIG. [Diagram 2] 1A and 1B are diagrams illustrating the principle of adjusting the vacuum wall of a flexible cryoablation needle with adjustable vacuum wall position according to one embodiment of the present invention. [Diagram 3]FIG. 1 illustrates a pre-purge mode of a rigid cryoablation needle vacuum wall full conditioning scheme in accordance with a preferred embodiment of the present invention. [Figure 4] FIG. 1 illustrates the freeze mode of the vacuum wall full modulation scheme of a rigid cryoablation needle in accordance with a preferred embodiment of the present invention. [Diagram 5] FIG. 2 is a schematic diagram illustrating a vacuum wall of a flexible cryoablation needle according to a preferred embodiment of the present invention. [Figure 6] 1 illustrates a pre-purge mode of a full vacuum wall conditioning scheme for a flexible cryoablation needle in accordance with a preferred embodiment of the present invention. FIG. [Figure 7] FIG. 1 illustrates the freeze mode of the vacuum wall full modulation scheme of a flexible cryoablation needle in accordance with a preferred embodiment of the present invention. [Figure 8] 1 is a schematic diagram of a slider according to a preferred embodiment of the present invention. [Figure 9] 1 is a schematic diagram of a snap member according to a preferred embodiment of the present invention; [Figure 10] FIG. 1 illustrates a pre-purge mode of the rigid cryoablation needle front vacuum wall adjustment scheme in accordance with a preferred embodiment of the present invention. [Figure 11] FIG. 1 illustrates the freezing mode of the front vacuum wall adjustment scheme of a rigid cryoablation needle in accordance with a preferred embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0030] The technical solutions in the embodiments of the present invention will be described below in a clear and complete manner in conjunction with the drawings in the embodiments of the present invention, but it is clear that the described embodiments are only a part of the embodiments of the present invention, and are not all of them. Based on the embodiments of the present invention, all other embodiments that can be obtained by those skilled in the art without any creative efforts shall fall within the protection scope of the present invention.

[0031] In describing the present specification, it should be understood that the terms "upper", "lower", "top", "bottom", "lower", "top" and the like refer to an orientation or positional relationship based on that shown in the accompanying drawings and are intended only to facilitate and simplify the description of the present invention, and do not indicate or imply that the referenced device or element has a particular orientation or must be constructed and operated in a particular orientation, and therefore are not to be construed as limitations of the present invention.

[0032] In the description of the present specification, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying a relative importance or a number of technical features depicted. Thus, features qualified as "first" and "second" may explicitly or implicitly include one or more such features.

[0033] In the present description, "plurality" means, for example, two, three, four, etc., unless otherwise limited.

[0034] The technical solutions of the present invention are described in detail below by taking specific examples. These specific examples below can be combined with each other, and some examples do not repeat the same or similar concepts or processes.

[0035] 1 and 2 are diagrams illustrating the principle of adjusting the vacuum wall of a cryoablation needle with an adjustable vacuum wall position according to one embodiment of the present invention.

[0036] 1 and 2, the cryoablation needle with adjustable vacuum wall position according to this embodiment includes a vacuum wall, a JT slot 1 and a vacuum wall adjustment device, the vacuum wall includes a needle bar 21 and an inner tube 22, and the distal end of the needle bar 21 has a needle tip 211. The inner tube 22 is drilled into the needle bar 21, and a sandwich is formed between the inner tube 22 and the needle bar 21, the sandwich can form a vacuum, which can be either a permanent vacuum sandwich or a real-time vacuum sandwich, and the vacuum sandwich plays the role of insulating and preventing frostbite of normal tissue.

[0037] There is a first predetermined distance between the distal end of the inner tube 22 and the distal end of the needle bar (this first predetermined distance can be understood as a spacing distance along the axial direction of the vacuum wall), and the distal end of the inner tube 22 is the end of the inner tube 22 close to the needle tip 211. The JT slot 1 is drilled in the inner tube 22.

[0038] Among the regions distributed along the axial direction of the vacuum wall, the region in which the vacuum sandwich is located is the vacuum insulation region 26 since the vacuum sandwich can perform the role of insulation, and the region in which the first predetermined distance is located is the target region 25.

[0039] The distal end of the vacuum wall has at least two adjustment positions, a first adjustment position and a second adjustment position, and further, the distal end of the vacuum wall is switchable between the at least two adjustment positions relative to the JT slot (e.g., by moving along the axial direction of the vacuum wall), the at least two adjustment positions including a first adjustment position and a second adjustment position, and when the distal end of the vacuum wall is in the first adjustment position, the distal end of the JT slot 1 may be understood to be located within the target region 25 and in the freezing mode, as shown in the dashed portion of FIG. 1, and the distal end of the JT slot 1 is the end closer to the needle tip 211 of the JT slot 1, and when the distal end of the vacuum wall is in the second adjustment position, the distal end of the JT slot 1 may be understood to be located within the vacuum insulation region 26 and in the pre-purge mode, as shown in the solid line portion of FIG. 1.

[0040] The vacuum wall adjusting device is used to adjust the distal end of the vacuum wall to switch between the at least two adjustment positions, and specifically, can adjust the distal end of the vacuum wall to switch between at least two adjustment positions according to an external operation. Furthermore, any device that can realize this switching adjustment function may be used without departing from the description of the present solution.

[0041] When the distal end of the vacuum wall is in the first adjustment position, the distal end of the JT slot 1 has a second predetermined distance between it and the needle tip 211, which at least ensures that the ice ball formed by freezing covers the needle tip, i.e., that the refrigerant fluid returns from inside the target area 25 and inside the vacuum insulation area 26 after being expelled from the JT slot 1, where the refrigerant fluid exchanges heat with materials outside the entire target area while returning from inside the target area 25.

[0042] When the distal end of the vacuum wall is in the second adjustment position, the distal end of JT slot 1 has a third predetermined distance with the distal end of the vacuum insulation region, which at least ensures that the refrigerant fluid returns directly from within the vacuum insulation region after being expelled from JT slot 1, and there is only a relatively static refrigerant in the target region and no heat exchange with materials outside the target region, i.e., the refrigerant does not release any amount of cold in the target region during freezing. The distal end of vacuum insulation region 26 is the end of the vacuum insulation region near needle tip 211.

[0043] Here, when the distal end of the vacuum wall is in the second adjustment position, the refrigerant fluid is discharged from the JT slot 1 at a certain discharge distance, and in order to prevent the refrigerant fluid from reaching the target area after being discharged from the JT slot, a third predetermined distance is provided between the distal end of the JT slot and the distal end of the vacuum insulation area, and this third predetermined distance is made equal to or greater than the discharge distance of the refrigerant fluid, thereby ensuring that the refrigerant fluid returns directly from within the vacuum insulation area without reaching the target area after being discharged from the JT slot 1, and further ensuring that only a relatively static refrigerant exists in the target area.

[0044] The first, second and third predetermined distances here can be understood as interval distances along the axial direction of the vacuum wall. Furthermore, all axial directions described below can be understood as the axial direction of the vacuum wall.

[0045] In one embodiment, the vacuum wall is a hard material vacuum wall applicable to a percutaneous puncture cryoablation instrument, with the needle tip 211 being in the form of a tip, as shown in FIG.

[0046] In one embodiment, the vacuum wall is a flexible material vacuum wall applicable to transorificial ablation instruments, and the needle tip 211 is in the form of a circular arc, as shown in Fig. 2. Preferably, the needle bar 21 and the inner tube 22 can be soft non-metallic material or freely bendable metallic material, such as PTFE or PTFE braided tube or stainless steel bellows.

[0047] In one embodiment, the use process of the above-mentioned cryoablation needle with adjustable vacuum wall position is as follows: Before the treatment, take out the cryoablation needle in the pre-purge mode, interconnect with the main machine, insert the needle bar 21 (at least the target area 25) of the cryoablation needle into the saline solution, and start the tool test function. In the tool test, the rewarming stage is first performed, and if the temperature of the needle tip rises to a predetermined temperature within a certain time, the rewarming function is proven to be normal. Immediately after that, the program automatically performs the freezing stage, and if the temperature of the needle tip drops to a predetermined temperature within a certain time, the freezing function is proven to be normal. At this time, the time for keeping the needle tip at the lowest temperature can be appropriately extended to fully pre-purge, and then the tool test is automatically stopped. In the freezing stage, it can be observed whether there is frost on the vacuum insulation area 26, and if there is no frost, the insulation function is proven to be normal, and if there is no leakage at the needle tip immersed in saline solution during the entire stage, it is proven that the airtightness is normal. At the end of the tool test, both the main machine and the transport pipe of the cryoablation needle complete pre-purge (cooling). Immediately after that, the freezing function may be turned on first (or the separately set pre-purge function may be turned on), and the freezing at this stage may be performed at a low operating pressure or may be ventilated intermittently, thus saving gas usage while maintaining the temperature of the distal end of the JT slot at the lowest temperature. Next, with the freezing function turned on, the image-guided percutaneous puncture may be performed, and the needle tip may reach the desired tumor location. In this case, the movement of the distal end of the vacuum wall to the proximal end may be adjusted, stopped at the first adjustment position, and switched to the freezing mode. Since the entire transport duct is in a low temperature state, the cooling heat load of the cryoablation needle is only on the target region 25 and the tumor tissue outside it, and therefore, even if the freezing mode is switched on, the temperature of the distal end of the JT slot may be maintained at the lowest temperature, but the outer wall of the target region 25 may instantly drop from normal temperature to below -100°C.In this way, the treatment time for ablating a tumor of the same size is shortened, or a larger ablation range (ice ball) is formed within the same time, and the tumor tissue is cooled more rapidly, so the probability of intracellular ice damage to tumor cells is greatly increased, and subsequently the cryo-damage of tumor cells is more thorough and the ablation effect is better.

[0048] In one preferred embodiment, referring to Figures 3 and 4, adjustment of the distal end position of the vacuum wall is accomplished by full vacuum wall adjustment (JT slot 1 is fixed).

[0049] In one embodiment, the vacuum wall adjustment device may include a mandrel 3 and a slider 8, where the mandrel 3 is in the axial direction of the vacuum wall, the slider 8 is connected to the vacuum wall and located at the proximal end of the inner tube, and the slider 8 is used to drive the mandrel 3 to move axially, thereby moving the vacuum wall axially to switch the distal end of the vacuum wall between at least two adjustment positions, and as can be seen, the slider 8 and the vacuum wall are controllable to move synchronously along the axial direction.

[0050] Here, FIG. 3 is a diagram showing the pre-purge mode in which the distal end of the vacuum wall is in the second adjustment position, and FIG. 4 is a diagram showing the freeze mode in which the distal end of the vacuum wall is in the first adjustment position.

[0051] In the above embodiment, the mandrel 3 is the first slider guide, the slider 8 is provided on the outer wall of the mandrel 3, and the mandrel 3 guides the slider 8 to move along the axial direction. In another embodiment, a vacuum wall may be provided on the outer wall of the mandrel 3, and the slider 8 may be provided on the outer wall of the vacuum wall, so that the movement of the slider 8 further drives the vacuum wall to move along the mandrel 3. In another embodiment, the slider 8 may be guided by a guide tube provided in the axial direction of the vacuum wall, the guide tube being provided in the axial direction, and the slider 8 being provided on the inner wall of the guide tube and sliding along the guide tube, so that the slider 8 is guided to slide along the axial direction. In another embodiment, the first slider guide portion may be connected to the adjustable member (vacuum wall) and the slider may be connected to the first slider guide portion, the first slider guide portion being arranged in the axial direction and movable along the axial direction, and the slider 8 drives the first slider guide portion to move in the axial direction and further to move the vacuum wall in the axial direction.

[0052] In one embodiment, the slider 8 includes a central fixing hole 83 and two intake and return pipe fixing holes 85, see FIG. 8, the three holes can be linear, triangular, or different arrangement shapes according to actual needs. The mandrel 3, the intake pipe 6 and the return pipe 7 are respectively inserted into the central fixing hole 83 and the two intake and return pipe fixing holes 85 and sealed connected. The intake pipe 6 and the return pipe 7 are connected to the JT slot, the intake air to the JT slot enters from the intake pipe 6, and the return air from the JT slot is discharged from the return pipe 7.

[0053] In one embodiment, based on the embodiment of the total vacuum wall adjustment described above, a seal assembly is further included to prevent gas from leaking inside the vacuum wall during adjustment of the distal end position of the vacuum wall, see Figures 2 and 3. The seal assembly is sealingly connected to the proximal end of the inner tube 22, which is the end of the inner tube away from the needle tip 211, and a dynamic seal is provided between the seal assembly and the slider 8.

[0054] Further, the seal assembly includes a seal ring 51, a seal groove 52, and a seal pressing member 53. Here, the distal end of the seal groove 52 is fixedly sealed to the proximal end of the inner tube 22, the distal end of the seal groove 52 is the end of the seal groove close to the needle tip 211, the seal ring 51 is placed in the seal groove 52, and the seal pressing member 53 is screwed into the seal groove 52 along the axial direction, so that the seal ring 51 is fixed between the seal groove 52 and the seal pressing member 53, and the mandrel 3 is inserted into the seal ring 51 and the seal pressing member 53, so that the seal ring 51 is radially pressed between the mandrel 3 and the seal groove 52 to cause deformation and form a dynamic seal. Optionally, the seal ring 51 may be a rubber seal ring such as a nitrile O-ring, or a Variseal ring made of a low-temperature resistant fluoropolymer and a metal spring.

[0055] 5, in a preferred embodiment, the vacuum wall of the flexible cryoablation needle may further include a vacuum three-way tube 28, a vacuum connection tube 291, a vacuum hose 292 and a return air connection tube 293. Here, the proximal end of the inner tube 22 is hermetically connected to the distal end of the return air connection tube 293, the proximal end of the outer tube 23 is hermetically connected to the three-way tube connection part 281, the proximal end of the vacuum three-way tube 28 is hermetically connected to the return air connection tube 293, the distal end of the vacuum connection tube 291 is inserted into the three-way tube bypass 282, and the vacuum hose 292 is inserted into the vacuum connection tube 291, and the proximal end of the vacuum hose 292 is evacuated to maintain the gap between the inner tube 22 and the outer tube 23 in a vacuum state, which can prevent frostbite on the wall of a normal natural orifice.

[0056] In one embodiment, referring to Figures 6 and 7, the device further includes a shunt tube 294 for sealing gaps between the intake pipe 6, the return pipe 7 and the mandrel 3, and the intake pipe 6, the return pipe 7 and the mandrel 3 are inserted into and sealed at the proximal end of the shunt tube 294.

[0057] In one embodiment, based on the embodiment of the vacuum wall total adjustment described above, as shown in Figures 3, 4, 6, 7, the adjustment of the distal end position of the vacuum wall can be achieved by manual back and forth adjustment or pre-spring 120. The spring 120 is used to hold the distal end position of the vacuum wall, and when the spring 120 is in a compressed or extended state, the distal end of the vacuum wall is in the second adjustment position (pre-purge mode), see Figures 3, 6 for an example where the spring is in an extended state. When the spring is in its natural state, as shown in Figures 4, 7, the distal end of the vacuum wall is in the first adjustment position (freezing mode). Further, it includes a snap member 10, and when the distal end of the vacuum wall is in the second adjustment position, as shown in Figures 3, 4, 6, 7, the snap member is used to hold the spring 120 in an extended state, and when it is necessary to switch to the first adjustment position, it is only necessary to pull out the snap member 10.

[0058] In another embodiment, the spring may be configured to be in a compressed state when the distal end of the vacuum wall is in the second adjustment position, and to be in a natural state when the distal end of the vacuum wall is in the first adjustment position.

[0059] In one embodiment, for ease of gripping and adjustment, see Figs. 3 and 4, the lever 9 further includes a front lever 92 and a rear lever 93. The front lever includes a front adjustment segment 921 and a front limiting ring 922, and the rear lever 93 includes a rear adjustment segment 931, a rear limiting ring 932 and a slider fixing hole 933. The front lever 92 is fixedly connected to the vacuum wall, and the slider 8 is fixedly connected to the rear lever 93 via the slider fixing hole 933. The rear adjustment segment 931 is inserted into the front adjustment segment 921. The front limiting ring 922 and the rear limiting ring 932 restrict each other to limit adjustment of the distal position of the vacuum wall, and when the vacuum wall is moved to the second adjustment position, the front limiting ring 922 and the rear limiting ring 932 restrict each other to limit further distal movement of the vacuum wall (i.e., limiting the farthest the vacuum wall can move distally).

[0060] In another embodiment, the front lever 92 and the rear lever 93 may not include the front limiting ring 922 and the rear limiting ring 932 and may be limited by the proximal end of the front lever 92 and the distal end of the rear lever 93, see Figures 6 and 7.

[0061] 3 and 6, in a preferred embodiment, the snap member 10 is fixed as follows, specifically, the distal end of the spring 120 is fixedly connected to the distal end of the front adjustment segment 921, the proximal end of the spring 120 is fixedly connected to the rear limiting ring 932 (i.e., fixed relative to the slider 8), and the snap member 10 is connected to the distal end of the spring 120. When adopting a form in which the rear adjustment segment 931 is inserted into the front adjustment segment 921, the rear adjustment segment 931 is relatively thin, and in the pre-purge mode, a part of the rear adjustment segment 931 (between the proximal end of the front limiting ring 922 and the proximal end of the rear adjustment segment 931) is exposed, and the snap member 10 can fit snugly into this exposed part of the rear adjustment segment 931, thereby fixing the relative positions of the slider 8 and the vacuum wall, and at this time, the spring 120 is in a raised state, i.e., the current pre-purge mode is maintained. When it is necessary to switch the pre-purge mode to the freezing mode, refer to Figures 4 and 7, grip the rear lever 93 and pull out the snap member 10, and under the tension of the spring 120, the slider 8 drives the front lever 92, i.e., drives the vacuum wall to move toward the proximal end until the proximal end of the vacuum wall is pressed against the rear lever 93 (the distal end of the slider fixing hole 933), at which time the vacuum wall stops at the first adjustment position and is switched to the freezing mode.

[0062] In one embodiment, when the cryoablation catheter is flexible and includes a shunt tube 294, referring to Figures 6 and 7, the rear adjustment segment 931 of the lever is further provided with a shunt tube fixing hole 934 for passing the shunt tube 294 and restricting it radially.

[0063] In one embodiment, when the cryoablation catheter is flexible and includes a vacuum hose 292, referring to Figures 6 and 7, the rear adjustment segment 931 of the lever is further provided with a hose guide tube 935 for passing and guiding the vacuum hose 292.

[0064] In a preferred embodiment, in order to facilitate fixing of the snap member and adjustment of the snap member for insertion and removal, referring to Fig. 9, the snap member 10 includes a gripping portion 101 and a C-shaped ring 103. Here, the gripping portion 101 is provided on the C-shaped ring 103 to facilitate gripping adjustment, and the C-shaped ring 103 is covered by the outer wall of the lever 9 to prevent the snap member from coming off in the radial direction.

[0065] In a preferred embodiment, referring to Figs. 3 and 4, the fin tube 4 is further included to improve the heat dissipation function, and the fin tube 4 is provided on the outer wall of the mandrel 3.

[0066] In a preferred embodiment, based on the above embodiment of the vacuum wall overall adjustment, for example, the fin tube 4 may be pushed into the proximal end of the inner tube to expand the internal volume of the proximal end of the inner tube, or more parts may be accommodated, and the internal volume of the proximal end of the inner tube needs to be expanded, so the internal volume of the proximal end of the vacuum wall also needs to be expanded. Referring to Figures 3 and 4, the vacuum wall further includes an outer tube 23 and a gasket 24. Here, the gasket 24 is provided between the outer wall of the distal end of the inner tube 22 and the inner wall of the needle bar 21, so as to be sealed and connected, the distal end of the outer tube 23 is sealed and connected to the proximal end of the needle bar 21, and the proximal end of the outer tube 23 is sealed and connected to the proximal end of the inner tube 22. The outer diameter of outer tube 23 is larger than the outer diameter of needle bar 21, the inner diameter of outer tube 23 is larger than the inner diameter of the needle bar, the distal end of outer tube 23 is the end close to needle tip 211 of outer tube 23, and the proximal end of outer tube 23 is the end away from needle tip 211 of outer tube 23. Furthermore, from the distal end to the proximal end of inner tube 22, inner tube 22 includes inner tube front section 221 and inner tube rear section 222, in that order, the outer diameter of inner tube rear section 222 is larger than the outer diameter of inner tube front section 221, and the inner diameter of inner tube rear section 222 is larger than the inner diameter of inner tube front section 221. Inner tube front section 221 is located inside needle bar 21, and inner tube rear section 222 is located inside outer tube 23.

[0067] In a preferred embodiment, referring to Figures 10 and 11, the adjustment of the distal end position of the vacuum wall may be realized by dividing the vacuum wall into two parts, a front vacuum wall and a rear vacuum wall, adjusting only the front vacuum wall, and fixing the rear vacuum wall. Specifically, from the distal end to the proximal end of the vacuum wall, the vacuum wall includes a front vacuum wall and a rear vacuum wall in order, the front vacuum wall and the rear vacuum wall are relatively slidable, and the vacuum wall adjustment device includes a slider 8, which is connected to the front vacuum wall. The slider 8 is used to move the front vacuum wall along the axial direction to drive the distal end of the front vacuum wall to switch between at least two adjustment positions.

[0068] In one embodiment, the mandrel 3 is used as the second slider guide, a vacuum wall may be provided on the outer wall of the mandrel 3 and the slider 8 may be provided on the outer wall of the vacuum wall, so that the movement of the slider 8 further drives the vacuum wall to move along the mandrel 3. In another embodiment, the slider 8 may be provided on the outer wall of the mandrel 3, which guides the axial movement of the slider 8. In another embodiment, the slider 8 may be guided by a guide tube provided in the axial direction of the vacuum wall, which is provided in the axial direction and the slider 8 is provided on the inner wall of the guide tube and slides along the guide tube, so that the slider 8 is guided to slide along the axial direction. In another embodiment, the second slider guide portion may be connected to the adjustable member (front vacuum wall) and the slider may be connected to the second slider guide portion, the second slider guide portion being arranged in the axial direction and movable along the axial direction, and the slider 8 drives the second slider guide portion to move in the axial direction and further to move the front vacuum wall in the axial direction.

[0069] In a preferred embodiment, based on the embodiment in which the vacuum wall is divided into two parts described above, the proximal end of the needle bar 21 is provided with an outer tube 23, the outer diameter of the outer tube 23 is larger than the outer diameter of the needle bar 21, and the inner diameter of the outer tube 23 is larger than the inner diameter of the needle bar 21. From the distal end to the proximal end of the inner tube 22, the inner tube 22 includes an inner tube front section 221 and an inner tube rear section 222, in that order, the outer diameter of the inner tube rear section 222 is larger than the outer diameter of the inner tube front section 221, and the inner diameter of the inner tube rear section 222 is larger than the inner diameter of the inner tube front section 221. The inner tube front section 221 is located inside the needle bar 21, and the inner tube rear section 222 is located inside the outer tube 23. In this case, the front vacuum wall and the rear vacuum wall are divided so that the front vacuum wall includes the needle bar 21 and the inner tube front section 221, and the rear vacuum wall includes the outer tube 23 and the inner tube rear section 222. In order to enhance the sealing effect, the front vacuum wall further includes a gasket 24, which is provided between the outer wall of the distal end of the inner tube front section 221 and the needle bar 21, and between the outer wall of the proximal end of the inner tube front section 221 and the needle bar 21.

[0070] In a preferred embodiment, based on the embodiment in which the vacuum wall is divided into two parts as described above, see Figs. 10 and 11, a dynamic seal is formed between the front vacuum wall and the rear vacuum wall by a seal assembly to prevent gas leakage between them. The seal assembly includes a seal ring 51 and a seal groove 52. Here, the seal groove 52 is located between the front vacuum wall and the rear vacuum wall, and the seal ring 51 is located between the outer wall at the distal end of the front vacuum wall and the seal groove 52, and the seal ring 51 can move axially along the seal groove to follow the front vacuum wall, thereby realizing a dynamic seal. In this embodiment, the seal ring 51 is located on the outer surface of the front vacuum wall, and this area is at room temperature, so that a normal rubber seal ring can be used without worrying about poor sealing at low temperatures.

[0071] In a preferred embodiment, based on the embodiment in which the vacuum wall is divided into two parts as described above, in order to facilitate the adjustment of the slider 8, a toggle 86 and a lever 9 are further provided, and a lever adjustment slot 94 is provided inside the lever 9, as shown in Figs. 10 and 11. The slider 8 is fixed to the outer surface of the front vacuum wall, and the toggle 86 is connected to the slider 8, and the toggle 86 protrudes from the lever adjustment slot 94 to the outer wall of the lever 9 to facilitate the adjustment. By sliding the toggle 86 in the lever adjustment slot 94, the slider 8 can be driven to move axially. In order to facilitate the fixing of the adjustment position of the distal end of the vacuum wall, the length of the lever adjustment slot 94 can be set according to the distal end position of the vacuum wall, and when the toggle 86 is located at the farthest end of the lever adjustment slot 94, the distal end of the vacuum wall is just at the second adjustment position, and when the toggle 86 is located at the nearest end of the lever adjustment slot 94, the distal end of the vacuum wall is just at the first adjustment position.

[0072] In a preferred embodiment, in order to better detect the freezing effect of the cryoablation needle, see Figs. 3, 4, 6, 7, 10, 11, further includes a temperature measurement line 14, the distal end of which is a temperature measurement point 141, and the distal end of the temperature measurement line 14 is the end close to the needle tip 211 of the temperature measurement line 14. The temperature measurement point 141 is provided at the distal end of the JT slot 1 and is used to measure the temperature at the distal end of the JT slot 1. When the distal end of the JT slot 1 is located in the target area, the temperature measurement point 141 is used to monitor the temperature of the tumor center during cryo-rewarming, and when the distal end of the JT slot 1 is located in the vacuum insulation area, the temperature measurement point 141 is used during pre-purge to indicate whether pre-purge is performed properly or not. The temperature measurement line 14 is led from the inside to the outside of the mandrel 3 along the outside of the JT slot 1, and the inside of the mandrel 3 is sealed by filling with adhesive. Preferably, the heating line is further included, and the heating line is positioned and arranged in a manner consistent with the temperature measurement line and is used to realize the heating function. Preferably, the temperature measurement line and / or the heating line employs a T-type enameled thermocouple wire.

[0073] In one embodiment, in order to encase components such as the intake pipe, return pipe, etc., and to make the cryoablation needle look neater and easier to operate, an outer sleeve 13 is further provided on the outer wall of the lever 9, see Figs. 3, 4, 6, 7, 10 and 11.

[0074] In a preferred embodiment, the pre-purge mode, i.e., the distal end of JT slot 1 is located inside vacuum insulation region 26, can be set as the product's factory default state, and the operator can complete the product pre-purge directly through the tool test process. After the tool test / pre-purge is completed, adjust to the freeze mode, where the distal end of JT slot 1 is located inside target region 25, and when freezing begins, the target region 25 will be rapidly cooled to the lowest temperature because the ablation needle has performed pre-purge.

[0075] In the description herein, terms such as "one embodiment," "one example," "particular implementation," "example," and the like, mean that the particular feature, structure, material, or characteristic described in connection with that example or example is included in at least one example or example of the present invention. In the present specification, exemplary expressions of the above terms do not necessarily refer to the same example or example. Moreover, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more examples or examples.

[0076] Finally, it should be explained that the above-mentioned embodiments are merely for illustrating the technical solutions of the present invention, and are not intended to limit the same. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art can understand that the technical solutions described in the above embodiments may be modified, or part or all of the technical features may be equivalently replaced, and such modifications or replacements do not cause the essence of the corresponding technical solutions to depart from the scope of the technical solutions of the embodiments of the present invention. [Explanation of symbols]

[0077] 1 - JT slot; 21-Needle bar; 211-needle tip; 22-inner tube; 221-Inner tube front stage; 222-inner tube rear stage; 23-external tube; 24 - gasket; 25-target area; 26-Vacuum insulation area; 28-vacuum three-way tube; 281-Three-way pipe connections; 282-Three-way pipe bypass; 291-Vacuum connecting tube; 292 - vacuum hose; 293-return air connection pipe; 294-Shunt tube; 3 - mandrel; 4-fin tube; 51 - sealing ring; 52 - sealing groove; 53-seal pressing member; 6-intake pipe; 7-return trachea; 8-slider; 83-central fixing hole; 85-Fixing holes for intake and return air pipes; 86 - toggle; 9 - lever; 92 - front lever; 921 - front adjustment segment; 922 - front limiting ring; 93 - rear lever; 931 - rear adjustment segment; 932 - rear limiting ring; 933 - slider fixing hole; 934-Shunt tube fixing hole; 935 - hose guide tube; 94 - Lever adjustment slot; 10-Snap parts; 101-grip; 103-C type ring; 120-spring; 13-external sleeve; 14-Temperature measuring line; 141 - Temperature measurement point.

Claims

1. a vacuum wall, a JT slot, and a vacuum wall adjustment device; the vacuum wall includes a needle bar and an inner tube; the distal end of the needle bar has a needle tip; the inner tube is inserted into the needle bar, and a sandwich is formed between the inner tube and the needle bar, and the sandwich is capable of forming a vacuum; a distal end of the inner tube has a first predetermined distance from a distal end of the needle bar along an axial direction of the vacuum wall, the distal end of the inner tube being an end of the inner tube close to the needle tip; The JT slot is drilled in the inner tube, the needle tip is switchable between at least two adjustment positions with respect to the JT slot, the at least two adjustment positions including a first adjustment position and a second adjustment position; Among the regions distributed along the axial direction of the vacuum wall, the region in which the sandwich is located is a vacuum insulation region, and the region in which the first predetermined distance is located is a target region; when the needle tip is in a first adjusted position, a distal end of the J-T slot is located within the target area, and the distal end of the J-T slot is an end of the J-T slot proximal to the needle tip; when the needle tip is in a second adjustment position, a distal end of the JT slot is located within the vacuum insulation region; the vacuum wall adjustment device is used to adjust the position of the needle tip, thereby switching the needle tip between the at least two adjustment positions; The vacuum wall adjustment device includes a first slider and a first slider guide portion; The first slider and the vacuum wall can be controlled to move synchronously along a guide direction by the first slider guide portion, thereby switching the adjustment position of the needle tip, and the first slider guide portion is used to guide the first slider and the vacuum wall to move along an axial direction of the vacuum wall; When the needle tip is in the first adjustment position, the distal end of the JT slot has a second predetermined distance along the axis of the vacuum wall from the needle tip, the second predetermined distance being at least sufficient to ensure that an ice ball formed upon freezing covers the needle tip; A cryoablation needle with an adjustable vacuum wall position, characterized in that when the distal end of the vacuum wall is in the second adjustment position, the distal end of the J-T slot has a third predetermined distance along the axial direction of the vacuum wall between it and the distal end of the vacuum insulation region, the third predetermined distance at least ensuring that refrigerant returns directly from within the vacuum insulation region after being discharged from the J-T slot, and the distal end of the vacuum insulation region is an end of the vacuum insulation region that is close to the needle tip.

2. the first slider guide portion is provided along an axial direction of the vacuum wall, the first slider is connected to the vacuum wall, and a position of the first slider guide relative to the slider or the JT slot is constant; 2. The cryoablation needle with adjustable vacuum wall position according to claim 1, wherein, when a position of the first slider guide portion relative to the slider is constant, the first slider guide portion and the J-T slot are relatively slidable, and when a position of the first slider guide portion relative to the J-T slot is constant, the first slider and the first slider guide portion are relatively slidable.

3. a first seal assembly, the first seal assembly being in sealing connection with a proximal end of the inner tube, the proximal end of the inner tube being an end of the inner tube remote from the needle tip; 3. The adjustable vacuum wall position cryoablation needle of claim 2, wherein a dynamic seal is provided between said first seal assembly and said first slider.

4. The first seal assembly includes a seal ring, a seal groove, and a seal pressing member, a distal end of the seal groove fixedly sealed to a proximal end of the inner tube, the distal end of the seal groove being an end of the seal groove proximal to the needle tip; The seal ring is provided between the seal pressing member and a first slider, and the seal pressing member is provided between the seal ring and a seal groove, The seal ring and the seal pressing member are slidably connected to the seal groove, 4. The cryoablation needle with adjustable vacuum wall position according to claim 3, wherein the first slider, the seal ring and the seal pressing member are controllable to move synchronously along an axial direction.

5. further comprising a spring and a snap member; one end of the spring moves synchronously with the distal end of the JT slot and is also connected to the snap member, the snap member being capable of moving into and out of a snap position; The other end of the spring is fixed relative to the JT slot; When the snap member is in the snap position, the spring is held in a deformed state by the restriction of the snap member and the distal end of the vacuum wall is in the second adjustment position; The deformation state is a compression state or an extension state, 3. The cryoablation needle with adjustable vacuum wall position as claimed in claim 2, wherein when the snap member is released from the snap position, the spring is capable of generating a restoring force to return from the deformed state to a natural state, and the restoring force is capable of driving the distal end of the vacuum wall to advance from the second adjustment position to the first adjustment position.

6. Further comprising a first lever, said first lever comprising a front lever and a rear lever; the front lever is fixedly connected to the vacuum wall; a distal end of the rear lever is inserted into a proximal end of the front lever, and the two are slidable relative to each other; 6. The cryoablation needle with adjustable vacuum wall position according to claim 5, characterized in that the front lever and / or the rear lever are provided with a limiting ring, which is used to limit the farthest distance the vacuum wall can move towards its distal end.

7. The snap member includes a gripping portion and a C-ring. The gripping portion is provided on the C-shaped ring, The cryoablation needle with adjustable vacuum wall position according to claim 6, wherein the C-shaped ring is covered by the outer wall of the rear lever.

8. the vacuum wall further comprises an outer tube and a gasket; a distal end of the outer tube is sealingly connected to a proximal end of the needle rod, a proximal end of the outer tube is sealingly connected to a proximal end of the inner tube, the distal end of the outer tube being an end of the outer tube close to the needle tip, and the proximal end of the outer tube being an end of the outer tube away from the needle tip; the gasket is disposed between an outer wall of the inner tube and an inner wall of the needle bar to form a sealed connection; From the distal end to the proximal end of the inner tube, the inner tube includes, in order, an inner tube front section and an inner tube rear section; The front portion of the inner tube is formed in the needle bar, and the rear portion of the inner tube is formed in the outer tube, The cryoablation needle with an adjustable vacuum wall position according to any one of claims 1 to 7, characterized in that when the vacuum wall includes a front vacuum wall and a rear vacuum wall, the front vacuum wall includes the needle bar and the front section of the inner tube, and the rear vacuum wall includes the outer tube and the rear section of the inner tube.

9. The outer diameter of the outer tube is larger than the outer diameter of the needle bar, and the inner diameter of the outer tube is larger than the inner diameter of the needle bar, 9. The cryoablation needle with adjustable vacuum wall position as described in claim 8, characterized in that an outer diameter of the rear section of the inner tube is larger than an outer diameter of the front section of the inner tube, and an inner diameter of the rear section of the inner tube is larger than an inner diameter of the front section of the inner tube.

10. Further comprising a temperature measurement line; a distal end of the temperature measuring line is a temperature measuring point, the distal end of the temperature measuring line being an end of the temperature measuring line proximal to the needle tip; The cryoablation needle with adjustable vacuum wall position described in any one of claims 1 to 7, characterized in that the temperature measurement point is provided at a distal end of the JT slot and is used to measure the temperature of the distal end of the JT slot.

11. a vacuum wall, a JT slot, and a vacuum wall adjustment device; the vacuum wall includes a needle bar and an inner tube; the distal end of the needle bar has a needle tip; the inner tube is inserted into the needle bar, and a sandwich is formed between the inner tube and the needle bar, and the sandwich is capable of forming a vacuum; a distal end of the inner tube has a first predetermined distance from a distal end of the needle bar along an axial direction of the vacuum wall, the distal end of the inner tube being an end of the inner tube close to the needle tip; The JT slot is drilled in the inner tube, the needle tip is switchable between at least two adjustment positions with respect to the JT slot, the at least two adjustment positions including a first adjustment position and a second adjustment position; Among the regions distributed along the axial direction of the vacuum wall, the region in which the sandwich is located is a vacuum insulation region, and the region in which the first predetermined distance is located is a target region; when the needle tip is in a first adjusted position, a distal end of the J-T slot is located within the target area, and the distal end of the J-T slot is an end of the J-T slot proximal to the needle tip; when the needle tip is in a second adjustment position, a distal end of the JT slot is located within the vacuum insulation region; The vacuum wall includes a front vacuum wall and a rear vacuum wall, the front vacuum wall and the rear vacuum wall are sequentially distributed from the distal end to the proximal end of the vacuum wall, the front vacuum wall and the rear vacuum wall are relatively movable, and the needle tip is located at the front vacuum wall; the vacuum wall adjustment device adjusts a relative position between the front vacuum wall and the rear vacuum wall to switch the needle tip between the at least two adjustment positions; the vacuum wall adjustment device includes a second slider and a second slider guide; The second slider and the front vacuum wall are controllable to move along a guide direction by the second slider guide, thereby switching the adjustment position of the needle tip, and the second slider guide is used to guide the second slider and the front vacuum wall to move along an axial direction of the vacuum wall; When the needle tip is in the first adjustment position, the distal end of the JT slot has a second predetermined distance along the axis of the vacuum wall from the needle tip, the second predetermined distance being at least sufficient to ensure that an ice ball formed upon freezing covers the needle tip; A cryoablation needle with an adjustable vacuum wall position, characterized in that when the distal end of the vacuum wall is in the second adjustment position, the distal end of the J-T slot has a third predetermined distance along the axial direction of the vacuum wall between it and the distal end of the vacuum insulation region, the third predetermined distance at least ensuring that refrigerant returns directly from within the vacuum insulation region after being discharged from the J-T slot, and the distal end of the vacuum insulation region is an end of the vacuum insulation region that is close to the needle tip.

12. the second slider guide portion is provided along an axial direction of the vacuum wall, the second slider is connected to the front vacuum wall, and a position of the second slider guide portion relative to the front vacuum wall or the rear vacuum wall is constant; 12. The cryoablation needle with adjustable vacuum wall position according to claim 11, wherein, when the position of the second slider guide portion relative to the rear vacuum wall is constant, the second slider and the second slider guide portion are slidable relative to each other, and when the position of the second slider guide portion relative to the front vacuum wall is constant, the rear vacuum wall and the second slider guide portion are slidable relative to each other.

13. 13. The cryoablation needle with adjustable vacuum wall position as claimed in claim 12, further comprising a second seal assembly disposed between the front and rear vacuum walls and used to form a dynamic seal between the front and rear vacuum walls.

14. a toggle and a second lever, the second lever including a lever adjustment slot; The toggle is connected to the second slider, the toggle is disposed within the lever adjustment slot, and the toggle protrudes from an outer wall of the second lever; the toggle is slidably connected to the lever adjustment slot; 13. The cryoablation needle with adjustable vacuum wall position as claimed in claim 12, wherein the toggle and the second slider are controllable to move synchronously along the axial direction.

15. the vacuum wall further comprises an outer tube and a gasket; a distal end of the outer tube is sealingly connected to a proximal end of the needle rod, a proximal end of the outer tube is sealingly connected to a proximal end of the inner tube, the distal end of the outer tube being an end of the outer tube close to the needle tip, and the proximal end of the outer tube being an end of the outer tube away from the needle tip; the gasket is disposed between an outer wall of the inner tube and an inner wall of the needle bar to form a sealed connection; From the distal end to the proximal end of the inner tube, the inner tube includes, in order, an inner tube front section and an inner tube rear section; The front portion of the inner tube is formed in the needle bar, and the rear portion of the inner tube is formed in the outer tube, The cryoablation needle with an adjustable vacuum wall position described in any one of claims 11 to 14, characterized in that when the vacuum wall includes a front vacuum wall and a rear vacuum wall, the front vacuum wall includes the needle bar and the front section of the inner tube, and the rear vacuum wall includes the outer tube and the rear section of the inner tube.

16. The outer diameter of the outer tube is larger than the outer diameter of the needle bar, and the inner diameter of the outer tube is larger than the inner diameter of the needle bar, 16. The cryoablation needle with adjustable vacuum wall position as described in claim 15, characterized in that an outer diameter of the rear section of the inner tube is larger than an outer diameter of the front section of the inner tube, and an inner diameter of the rear section of the inner tube is larger than an inner diameter of the front section of the inner tube.

17. Further comprising a temperature measurement line; a distal end of the temperature measuring line is a temperature measuring point, the distal end of the temperature measuring line being an end of the temperature measuring line proximal to the needle tip; The cryoablation needle with adjustable vacuum wall position described in any one of claims 11 to 14, characterized in that the temperature measurement point is provided at a distal end of the JT slot and is used to measure the temperature of the distal end of the JT slot.

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