Iron and / or calcium absorption enhancers

Abstract

The object of the present invention is to provide a new iron and / or calcium absorption enhancer. [Solution] An iron and / or calcium absorption promoter containing, as an active ingredient, one or more sea buckthorn components selected from the group consisting of sea buckthorn juice, dried sea buckthorn juice, dried sea buckthorn fruit, sea buckthorn fruit extract, and dried sea buckthorn fruit extract.

Description

[Technical field]

[0001] The present invention relates to an agent for enhancing absorption of iron and / or calcium. [Background technology]

[0002] Minerals are a general term for anything other than the four main elements that make up living organisms (oxygen, carbon, hydrogen, and nitrogen). Of these, 16 types of minerals are known as essential minerals that are indispensable for regulating and maintaining bodily functions. Mineral deficiencies can cause a variety of physical disorders, but because minerals cannot be synthesized in the body, they must be ingested to make up for any deficiencies. However, with today's diet, there is a tendency for minerals such as iron and calcium to easily become deficient.

[0003] Iron, an essential mineral, is a component of hemoglobin and various enzymes. It is known that iron deficiency can cause anemia, impaired motor function, and impaired cognitive function. Approximately 1 to 2 mg of iron is lost in the body every day through metabolism, and this loss must be compensated for by absorbing iron from food. However, iron is one of the nutrients that is easily deficient, and the actual intake of iron is often less than the recommended intake. Iron deficiency tends to be particularly prevalent among menstruating women and growing children.

[0004] In addition, calcium, an essential mineral, is found mostly in bones and teeth bound to phosphate, with only a small amount present in blood, muscles, nerves, etc. It is known that a calcium deficiency can cause osteoporosis, neuralgia, etc.

[0005] Therefore, with the aim of preventing iron and calcium deficiency and enhancing absorption, food and supplements that promote absorption have been developed (for example, Patent Documents 1, 2, 3, etc.). [Prior art documents] [Patent documents]

[0006] [Patent Document 1] JP 2012-162485 A [Patent Document 2] JP 2009-067688 A [Patent Document 3] Patent No. 6872699 Summary of the Invention [Problem to be solved by the invention]

[0007] An object of the present invention is to provide a new iron and / or calcium absorption enhancer. [Means for solving the problem]

[0008] The present inventors have conducted extensive research to solve the above problems, and as a result have found that the following invention meets the above object, thereby completing the present invention. <1> An iron and / or calcium absorption enhancer comprising as an active ingredient one or more sea buckthorn components selected from the group consisting of sea buckthorn juice, dried sea buckthorn juice, dried sea buckthorn fruit, sea buckthorn fruit extract, and dried sea buckthorn fruit extract. <2> The composition is an oral composition. <1> 2. An iron and / or calcium absorption enhancer according to claim 1. <3> The daily intake amount of the sea buckthorn component per adult human is 100 mg or more and 50,000 mg or less in terms of solid content. <1> or <2> 2. An iron and / or calcium absorption enhancer according to claim 1. Effect of the Invention

[0009] According to the present invention, a new iron and / or calcium absorption enhancer is provided. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The following is a detailed description of the embodiments of the present invention, but the following description of the constituent elements is one example (representative example) of the embodiment of the present invention, and the present invention is not limited to the following content as long as the gist of the present invention is not changed. Note that in this specification, when the expression "~" is used, it is used as an expression including the numerical value or physical property value before and after it.

[0011] The present invention relates to an absorption enhancer for iron and / or calcium (hereinafter, sometimes referred to as "the absorption enhancer of the present invention") containing, as an active ingredient, one or more sea buckthorn components selected from the group consisting of sea buckthorn juice, dried sea buckthorn juice, dried sea buckthorn fruit, sea buckthorn fruit extract, and dried sea buckthorn fruit extract.

[0012] (Sea Buckthorn) Sea buckthorn (Hippophae rhamnoides L., English name: Sea buckthorn) is a plant of the Elaeaceae family native to Europe and Asia, and is a thorny deciduous shrub or tree that grows to about 2 to 5 m. The sea buckthorn components contained in the iron and / or calcium absorption promoter of the present invention, namely, sea buckthorn fruit juice, dried sea buckthorn fruit juice, dried sea buckthorn fruit extract, and dried sea buckthorn fruit extract, are obtained from sea buckthorn fruit. The sea buckthorn fruit may be used in the form of pulp obtained by removing the skin and seeds from the sea buckthorn fruit, or in the form of fruit containing the skin and pulp obtained by removing the seeds from the sea buckthorn fruit, or in the form of fruit containing the skin, pulp, and seeds without removing the skin and seeds from the sea buckthorn fruit.

[0013] (Sea Buckthorn Juice) Sea buckthorn fruit juice is a liquid or semi-liquid obtained by squeezing or crushing sea buckthorn fruit. Examples of sea buckthorn fruit juice include straight juice obtained by squeezing sea buckthorn fruit, concentrated juice obtained by concentrating straight juice, diluted juice obtained by diluting straight juice, puree obtained by crushing with a mixer, grinder, crusher, crusher, etc., and paste obtained by concentrating puree, and may be a mixture of these. Sea buckthorn fruit juice may be used after squeezing or crushing sea buckthorn fruit, and then centrifuging, filtering, or straining as appropriate. Straining can be performed by passing through a mesh (for example, 40 to 60 mesh). Straining can remove at least a part of the skin, seeds, and fibrous flesh of the fruit.

[0014] For example, liquid or semi-liquid sea buckthorn juice obtained by squeezing or crushing sea buckthorn fruits, liquid or semi-liquid sea buckthorn juice obtained by squeezing or crushing sea buckthorn fruits and then straining them, or a mixture of these can be used.

[0015] (Dried sea buckthorn juice) The dried sea buckthorn juice is obtained by drying the sea buckthorn juice. The drying can be carried out by a known drying method such as sun drying, heat drying, reduced pressure drying, lyophilization (freeze drying), spray drying, etc. Also, the dried powder may be obtained by powdering the fruit during drying using spray drying, etc.

[0016] (Dried Sea Buckthorn Fruit) The dried sea buckthorn fruit is obtained by drying the sea buckthorn fruit. The drying can be carried out by a known drying method such as sun drying, heat drying, reduced pressure drying, lyophilization (freeze drying), spray drying, etc. Furthermore, the fruit may be appropriately pulverized or crushed during drying to obtain a pulverized or crushed product.

[0017] (Sea Buckthorn Fruit Extract) Seabuckthorn fruit extract is a solution in which the components in seabuckthorn fruit are extracted in a solvent. The seabuckthorn fruit extract may be obtained by directly immersing the seabuckthorn fruit in a solvent, or by immersing the seabuckthorn fruit in a solvent after crushing or drying the fruit appropriately.

[0018] (Dried sea buckthorn fruit extract) The dried product of sea buckthorn fruit extract is obtained by drying the sea buckthorn fruit extract. Drying can be performed by a known drying method such as sun drying, heat drying, reduced pressure drying, lyophilization (freeze drying), spray drying, etc. Also, the dried powder may be obtained by powdering the extract during drying using spray drying, etc.

[0019] In particular, the sea buckthorn component of the absorption enhancer of the present invention preferably contains one or more selected from the group consisting of sea buckthorn juice, dried sea buckthorn juice, and dried sea buckthorn fruit, and more preferably contains sea buckthorn juice and / or dried sea buckthorn juice.

[0020] (Promotes absorption of iron and / or calcium) The absorption enhancer of the present invention can enhance the absorption of iron and / or calcium. The absorption enhancer of the present invention can enhance the absorption of iron such as non-heme iron by the sea buckthorn component. Furthermore, by ingesting the absorption enhancer of the present invention during meals, the sea buckthorn component enhances the absorption of iron and calcium contained in the meal. This can increase the absorption of iron and calcium into the body.

[0021] (Oral Composition) The absorption enhancer of the present invention can be used as a food composition or a pharmaceutical composition, and is preferably in the form of an oral composition.

[0022] The content of the sea buckthorn component in the absorption enhancer of the present invention is designed according to the intake method, etc., so that the amount of the sea buckthorn component converted into solid content is the target intake amount per adult human per day. For example, the absorption enhancer of the present invention preferably contains 100 mg or more of the sea buckthorn component converted into solid content as the daily intake amount per adult human, more preferably contains 500 mg or more, and even more preferably contains 1000 mg or more. There is no particular limit to the upper limit of the content of the sea buckthorn component in the absorption enhancer of the present invention, but the amount of the sea buckthorn component converted into solid content as the daily intake amount per adult human is preferably 50,000 mg or less, more preferably 30,000 mg or less, and even more preferably 10,000 mg or less. The amount of the sea buckthorn fruit juice converted into solid content is the mass of the sea buckthorn fruit juice excluding water. Usually, the water content of the sea buckthorn fruit juice is about 80 to 90% by mass, so that the amount converted into solid content is about 10 to 20% by mass of the sea buckthorn fruit juice. The amount of the seabuckthorn fruit extract calculated as solid content is the mass of the seabuckthorn fruit extract excluding the solvent. For the dried seabuckthorn fruit juice, the dried seabuckthorn fruit, and the dried seabuckthorn fruit extract, the masses can be used as they are as the amount calculated as solid content.

[0023] The absorption enhancer of the present invention may be taken once a day or divided into several times a day (e.g., 2 to 4 times) so that the sea buckthorn component is taken in the above-mentioned amount. The absorption enhancer of the present invention may be taken continuously, and may be taken continuously for several days to several weeks or several months. The daily intake amount means the total amount taken or administered in one day, and when taken in several divided doses a day, it is the total amount of these.

[0024] (Food composition) The absorption enhancer of the present invention is preferably a food composition containing sea buckthorn components for promoting the absorption of iron and / or calcium. By forming it into a food composition, it is easy to take it on a daily basis over a long period of time, and it is possible to enhance the absorption of iron and / or calcium, which tends to be lacking in daily life. This food composition includes not only general foods, but also foods and / or beverages taken for the purpose of maintaining and improving health, such as special purpose foods, foods for specified health uses, foods with functional claims, foods with nutrient functions, nutritional supplements, health supplements, and supplements. Among these, foods with health functions, such as foods for specified health uses, foods with functional claims, and foods with nutrient functions, are preferred embodiments.

[0025] The shape of the food composition is not particularly limited, and may be any of solid, liquid, semisolid, gel, sol, etc. Foods and beverages are not particularly limited, and examples of foods include sausages, hams, seafood products, jellies, candies, chewing gums, and other foods. Beverages include various fruit juice drinks, teas, soft drinks, alcoholic beverages, and nutritional drinks. In addition to the sea buckthorn component, additives such as colorants, preservatives, thickening stabilizers, antioxidants, bleaching agents, antibacterial and antifungal agents, acidulants, seasonings, emulsifiers, strengthening agents, flavors, and sweeteners may be blended into the food composition.

[0026] When sea buckthorn juice is used, beverages (liquid beverages, purees, etc.) are one of the preferred embodiments. By making it into a beverage, the sea buckthorn juice can be used as it is, and its content can be easily adjusted. When making it into a beverage, the content of sea buckthorn juice in the beverage (mass of sea buckthorn juice / mass of beverage x 100 (%)) can be 30% by mass or more, 50% by mass or more, 60% by mass or more, 70% by mass or more, 80% by mass or more, 90% by mass or more, etc. In addition, there is no particular limit to the upper limit of the content of sea buckthorn juice in the beverage, and the sea buckthorn juice itself may be used as the beverage, or the upper limit may be appropriately set to 99.99% by mass or less, 99.98% by mass or less, etc.

[0027] Pharmaceutical Composition The absorption enhancer of the present invention can be a pharmaceutical composition for enhancing the absorption of iron and / or calcium, containing a sea buckthorn component. This pharmaceutical composition includes both medicines and quasi-drugs. When used as a pharmaceutical composition, the absorption enhancer of the present invention basically contains a sea buckthorn component and a pharma- ceutical acceptable carrier.

[0028] The dosage form of the pharmaceutical composition is not particularly limited, and may be a solid preparation or a liquid preparation.Specific examples include powders, granules, tablets, capsules, lozenges, suspensions, emulsions, syrups, elixirs, etc. Pharmaceutically acceptable carriers include, for example, binders, stabilizers, excipients, diluents, pH buffers, thickeners, colorants, dispersants, emulsifiers, suspending agents, preservatives, disintegrants, solubilizers, dissolution aids, etc.

[0029] The subject of use of the absorption enhancer of the present invention is not limited to humans, and may be an animal other than humans such as dogs and cats. Therefore, the absorption enhancer of the present invention may be used as an animal food composition such as pet food or an animal pharmaceutical composition. EXAMPLES

[0030] The present invention will be described in more detail below with reference to examples. However, the present invention is not limited to the following examples unless the gist of the present invention is changed.

[0031] A randomized, placebo-controlled crossover study was conducted to evaluate the effect of sea buckthorn drink intake on enhancing iron and calcium absorption.

[0032] 1. Test Food [Test food: Sea buckthorn drink (a drink containing sea buckthorn juice)] Ingredients (% by weight): Sea buckthorn puree (sea buckthorn fruit is put into a blender, passed through a mesh to remove the skin residue and seeds, and then subjected to high-temperature flash sterilization, solid content approximately 10%) 99.95%, Stevia (Asteraceae) 0.05% ·Form: Beverage Packaging: Packaged together for the entire consumption period Storage method: Store in a cool, dark place away from direct sunlight.

[0033] [Control food: placebo drink (drink not containing sea buckthorn juice)] Ingredients (by weight): Water 92.14%, Granulated sugar 5%, Casamas Yellow color 0.5%, Kiriyas Red color 0.02%, 85% phosphoric acid 0.75%, Creaming powder 1.2%, FE base (No. 36833) 0.04%, Vitamin C 0.3%, Stevia (Asteraceae) 0.05% ·Form: Beverage Packaging: Packaged together for the entire consumption period Storage method: Store in a cool, dark place away from direct sunlight.

[0034] 2. Dosage and Method of Intake The test food was administered at a dose of 30 mL per day. 10 mL of the test food was diluted with water and ingested three times a day (breakfast, lunch, and dinner).

[0035] 3. Test Method Randomized, double-blind, placebo-controlled, crossover study 1) SCR testing will be performed on 60 people. The SCR testing will involve informed consent, acquisition of consent, a subject background questionnaire, physical measurements, blood pressure, pulse, and clinical tests (blood tests, urine tests). 2) After fasting for at least 5 hours, the subjects will arrive at the hospital at 11:00, and their weight, blood pressure, pulse, and clinical tests (blood and urine tests) will be taken. After arrival, on the first day, lunch will be served at 13:00 and dinner at 19:00 (total calorie content of meals provided: 1130 kcal). Two 500 mL plastic bottles of drinking water (1000 mL) will be provided and subjects will be required to consume as needed. Anything above this will be allowed to be consumed ad libitum, but the amount provided will be recorded. Subjects will be allowed to go to bed around 22:00. On the second day, subjects will be woken up by 7:00 and made to urinate. Subjects will also be required to have a bowel movement by breakfast time. Blood pressure and pulse will be measured, and subjects will be given breakfast and test food (sea buckthorn juice or placebo drink) at 9:00, followed by lunch and test food (sea buckthorn juice or placebo drink) at 13:00, and dinner and test food (sea buckthorn juice or placebo drink) at 19:00 (total calorie content of meals provided: 1647 kcal). On the second day, urine was collected for two hours from 9:00 a.m., starting with breakfast, until 5:00 p.m. (The urine bottle was changed every two hours.) After 5:00 p.m., urine was collected until the first urine was collected the following morning upon waking. Weight, blood pressure, pulse rate, and clinical tests (blood and urine tests) were again performed when the subjects were discharged on the third day, completing Phase I of the study. 3) Have a washout period of at least one week. 4) After washout, subjects will be given a test food (sea buckthorn juice or a placebo drink) different from that in Period I in Period II, and the same procedure as in Period I will be repeated for 2 nights and 3 days. 5) During the study period, you will be required to keep a lifestyle diary.

[0036] Table 1 shows the overall test schedule, and Table 2 shows the time schedule for the overnight test.

[0037] [Table 1]

[0038] [Table 2]

[0039] 4.Results [Subject background] A screening test was conducted on 45 subjects, and 35 subjects who met the inclusion criteria and did not violate the exclusion criteria were selected, and 1 subject was selected as a preliminary subject. Selection Criteria (1) Those who are not suffering from any illness (2) Men and women aged 20 to 59 (3) BMI is 30 kg / m 2 Persons under (4) Subjects who can voluntarily consent to participate in the study in writing (5) People who can drink sea buckthorn juice on a regular basis ·Exclusion criteria (1) Those who are currently diagnosed with iron deficiency anemia and are receiving medical treatment (2) Persons currently receiving medication for any illness (3) Individuals who consume foods or health foods containing the test food (4) Anyone with a serious disease of glucose metabolism, lipid metabolism, liver function, kidney function, heart, circulatory system, respiratory system, endocrine system, immune system, nervous system, or mental illness, or a history of such a disease. (5) Subjects who have had abnormalities in clinical test values ​​and are deemed to be unable to participate in the study (6) Those who are currently undergoing treatment for a disease or have a history of a serious disease that required medical treatment (7) Subjects who are at risk of developing allergies related to the study (8) Subjects who are deemed unsuitable as subjects based on the results of a lifestyle questionnaire (9) Subjects who are participating in other clinical studies at the start of this study (10) Anyone who the investigator (or the person responsible for conducting the study) judges to be inappropriate to participate in the study

[0040] During the I and II visits, three patients dropped out, two for personal reasons and one for non-compliance with the guidelines. Therefore, the subjects for analysis were the 32 patients who participated in the study. Of the 32 patients, 19 were male and 13 were female. Table 3 shows the subject background.

[0041] [Table 3]

[0042] [evaluation] Evaluation items: Urinary mineral (iron, calcium) excretion (creatinine corrected amount) Evaluation method: At each intake period, a paired t-test was performed to compare between groups.

[0043] [Urinary mineral (iron, calcium) excretion results] It is known that the amount of minerals excreted in urine correlates with the amount of minerals absorbed, and an increase in the amount indicates an increase in the amount of minerals absorbed. The results of measuring the amount of minerals (Fe, Ca) in urine are shown in Table 4.

[0044] [Table 4]

[0045] The results showed that the amount of iron and calcium excreted in urine when seabuckthorn juice was consumed increased significantly compared to when a placebo was consumed, indicating that consumption of seabuckthorn juice increases the absorption of iron and calcium.

Claims

1. An absorption enhancer for iron and / or calcium, comprising, as an active ingredient, sea buckthorn puree, which is prepared by putting sea buckthorn fruits into a mixer and then passing them through a mesh to remove the skin residue and seeds, An oral composition, An agent for enhancing absorption of iron and / or calcium for individuals who are not suffering from any disease.

2. An absorption enhancer for iron and / or calcium, comprising, as an active ingredient, sea buckthorn puree, which is prepared by putting sea buckthorn fruits into a mixer and then passing them through a mesh to remove the skin residue and seeds, An oral composition, Iron and / or calcium absorption enhancers for non-diseased individuals, except (i) those containing alum, hawthorn and jujube, (ii) those containing haemoglobin iron, sophora japonica and hawthorn, or (iii) those containing blackcurrant.

3. 3. The iron and / or calcium absorption enhancer according to claim 1, wherein the amount of said sea buckthorn puree consumed per day by an adult human is 100 mg or more and 50,000 mg or less in terms of solid content.

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