Black hair regeneration essence and its manufacturing method

Abstract

The present invention provides a black hair regeneration essence containing a black hair regeneration composition containing, relative to the total amount of the black hair regeneration essence, 0.010% to 10.00% by mass of water lily extract, 0.010% to 5.00% by mass of sesame seed extract, 0.010% to 5.00% by mass of Polygonum polycentr extract, 0.0010% to 5.00% by mass of hydrolyzed flax seed extract, 0.00010% to 0.500% by mass of Neoporhiza crofuraliflora root extract, 0.0100% to 1.00% by mass of acetyl tyrosine, and 0.0010% to 1.00% by mass of European larch extract. The black hair regeneration composition in the black hair regeneration essence of the present invention combines active ingredients with different mechanisms of action for turning gray hair into black hair, increasing melanin production in the hair papilla, activating antioxidant defense to suppress damage caused by ROS to melanocytes, and stimulating the deposition of melanin in the hair, thereby regenerating black hair and slowly turning gray hair back into black hair.

Description

[Technical Field]

[0001] The present invention relates to the technical field of daily cosmetics, and in particular to a black hair regrowth essence and a method for producing the black hair regrowth essence. [Background technology]

[0002] Currently, most of the common black hair products on the market are cream-type hair dyes containing hair dyeing ingredients, and are generally broadly classified into chemical hair dyes and natural hair dyes depending on their formulation.

[0003] Chemical hair dyes are divided into permanent, semi-permanent, and temporary dyes based on their duration of effect. Permanent hair dyes contain dye intermediates and coupling or modifiers. These intermediates penetrate the inner medulla of the hair and undergo oxidation, coupling, and condensation reactions to form stable dye molecules. These molecules are then trapped within the hair fiber, making them resistant to washout and providing a long-lasting color, typically lasting 1-3 months. Semi-permanent hair dyes achieve a dark color by penetrating the cuticle or cortex and part of the medulla with relatively small molecular weight dye molecules, typically lasting 6-12 shampoo cycles. Temporary hair dyes are primarily used for temporary hair coloring and generally consist of water-soluble acid dyes, basic dyes, or pigments. They can also be composed of insoluble mixtures of acid dyes, ammonia, or metal salts. They adhere substantially to the surface of the hair, providing a temporary effect and posing a risk of inadvertent staining of clothing. These black hair products essentially use chemical hair dye ingredients to dye hair to achieve a black hair effect, but these products have many drawbacks, such as the dye effect not lasting long and requiring frequent repeated dyeing. However, repeated dyeing can cause scalp allergies and damage the hair, making it more susceptible to hair loss and dryness.

[0004] Natural hair dyes are plant-based hair dyes made from ingredients extracted from natural pigments. They generally do not damage hair or destroy accumulated pigments, but they only produce average black hair effects that last for a short time.

[0005] Scientists have discovered that the black color of human hair comes from melanocyte stem cells present between the hair root and the skin, and that hair remains black thanks to the pigment cells produced by these stem cells. When these stem cells decrease or become depleted, hair turns white, which is the underlying cause of black hair turning gray. However, conventional hair blackening products only turn gray hair black by dyeing it, and do not fundamentally solve the problem of gray hair.

[0006] Therefore, the present invention provides a black hair regeneration essence that does not contain any hair dye ingredients, but increases melanin production, activates antioxidant defenses, and suppresses damage to melanocytes, thereby reducing the number of gray hairs and slowly turning gray hair back into black hair. Summary of the Invention [Problem to be solved by the invention]

[0007] The first object of the present invention is to provide a black hair regrowth essence that solves the technical problems that conventional black hair products have; they contain dyeing ingredients, the black hair effect does not last long, and they are unable to fundamentally improve the occurrence of gray hair.

[0008] A second object of the present invention is to provide a method for producing a black hair regrowth essence. [Means for solving the problem]

[0009] The object of the present invention is achieved by the following technical means. The black hair regrowth essence of the present invention comprises a black hair regrowth composition containing, relative to the total amount of the black hair regrowth essence, 0.010% to 10.00% by mass of watercress extract, 0.010% to 5.00% by mass of sesame seed extract, 0.010% to 5.00% by mass of Polygonum polyosmodium extract, 0.0010% to 5.00% by mass of hydrolyzed linseed extract, 0.00010% to 0.500% by mass of Neoporhiza chrysanthemum rhizome root extract, 0.0100% to 1.00% by mass of acetyl tyrosine, and 0.0010% to 1.00% by mass of European larch extract.

[0010] Furthermore, the black hair regeneration composition contains 0.010% to 1.0% by mass of river jasmine extract, 0.010% to 0.5% by mass of sesame seed extract, 0.010% to 1.0% by mass of Polygonum polyosmodium extract, 0.0010% to 0.20% by mass of hydrolyzed linseed extract, 0.00010% to 0.20% by mass of Neoporhiza chrysanthemum rhododendron root extract, 0.0100% to 0.45% by mass of acetyl tyrosine, and 0.0010% to 0.15% by mass of European larch extract.

[0011] Furthermore, the black hair regeneration composition contains 0.3% by weight of watercress extract, 0.05% by weight of sesame seed extract, 0.414% by weight of Polygonum multiflorum extract, 0.0055% by weight of hydrolyzed flax seed extract, 0.0005% by weight of Neoporhiza chrysanthemum root extract, 0.17% by weight of acetyl tyrosine, and 0.06% by weight of European larch extract.

[0012] The black hair regrowth composition of the present invention combines active ingredients with different mechanisms of action that have been shown to be effective in transforming gray hair into black hair in vitro. This composition promotes the proliferation of pigment stem cells, increases melanin production in the hair papilla, activates antioxidant defenses to reduce ROS damage to melanocytes, and stimulates hair melanin deposition, thereby regrowing black hair and slowly turning gray hair back to black. In the present invention, the water hyacinth extract improves antioxidant properties and activates antioxidant defenses to reduce ROS damage to melanocytes. Black sesame, a traditional Chinese nutritional food with significant health benefits, exerts a powerful effect on tyrosinase activation and melanin production promotion. Black sesame extract positively affects cell proliferation, melanin content, and tyrosinase activity, promoting the expression of melanin synthesis-related genes (Tyrosinase / MITF / TRP-1 / TRP-2) mRNA and protein, thereby promoting melanin production and treating gray hair. Polygonum multiflorum extract is used to treat liver and kidney disorders, and has the effect of nourishing yin, maintaining a healthy balance in the body. Acetyl tyrosine is a prerequisite for the melanin synthesis pathway and increases melanin synthesis in melanocytes of the hair papilla.

[0013] In the present invention, the black hair regrowth essence further contains 0.5% by mass to 10% by mass of an auxiliary agent based on the total amount of the black hair regrowth essence.

[0014] In some embodiments of the present invention, the adjuvant comprises one or more of a conditioning agent and a preservative.

[0015] Furthermore, the conditioning agent is one or more of glycerin, pentylene glycol, PEG-40 hydrogenated castor oil, menthol, and dipotassium glycyrrhizinate.

[0016] In some embodiments of the present invention, the auxiliary further comprises a thickener, a pH stabilizer, and a chelating stabilizer.

[0017] Furthermore, the thickening agent is xanthan gum, the pH stabilizer is anhydrous citric acid and sodium citrate, and the chelating stabilizer is disodium EDTA.

[0018] In some embodiments of the present invention, the black hair regrowth essence comprises 0.3% by weight of river jasmine extract, 0.05% by weight of sesame seed extract, 0.414% by weight of Polygonum multiflorum extract, 0.0055% by weight of hydrolyzed linseed extract, 0.0005% by weight of Neoporhiza chrysanthemum rhododendron root extract, 0.17% by weight of acetyl tyrosine, 0.06% by weight of European larch extract, 3% by weight of pentylene glycol, 3% by weight of glycerin, 0.05% by weight of disodium EDTA, 0.2% by weight of xanthan gum, 0.2% by weight of sodium citrate, 0.12% by weight of citric acid, 0.2% by weight of dipotassium glycyrrhizinate, 0.2% by weight of menthol, and 1.0% by weight of PEG-40 hydrogenated castor oil.

[0019] The method for producing the black hair regeneration essence of the present invention is as follows: (1) mixing pentylene glycol, glycerin, disodium EDTA, xanthan gum, and dipotassium glycyrrhizinate in predetermined amounts and dissolving them to form a transparent solution A, and then mixing menthol, PEG-40 hydrogenated castor oil, and Tween-20, stirring, and dissolving them to form a solution B; (2) Adding watercress extract, sesame seed extract, Polygonum multiflorum extract, hydrolyzed flax seed extract, Neoporhiza crofloriflora root extract, acetyl tyrosine, and European larch extract to Preparation A in this order, dissolving, adding sodium citrate / citric acid to adjust the pH to 4.5-5.0, adding Preparation B, stirring, and cooling to obtain a black hair regeneration essence. [Effects of the Invention]

[0020] Compared with the prior art, the present invention has the following beneficial effects: (1) The black hair regeneration composition in the black hair regeneration essence of the present invention combines active ingredients with different mechanisms of action for turning gray hair into black hair, increasing melanin production in the hair papilla, activating antioxidant defense to suppress damage caused by ROS to melanocytes, and stimulating melanin deposition in the hair, thereby regenerating black hair and slowly turning gray hair back into black hair. (2) The black hair regeneration essence of the present invention does not contain any hair dye ingredients and can fundamentally improve gray hair without causing scalp allergies or damaging hair quality. [Brief explanation of the drawings]

[0021] [Figure 1] FIG. 1 shows the effect of the hydrolyzed flax seed extract of the present invention on tyrosinase. [Figure 2] FIG. 1 shows the effect of the hydrolyzed flax seed extract according to the present invention on the expression of TPR-1, MITF, Pmel17 and c-Kit. [Figure 3] FIG. 1 shows the effect of the hydrolyzed flax seed extract according to the present invention on the expression of PAR-2 ​​in keratinocytes. [Figure 4]FIG. 1 shows the effect of the Neoporhiza crofloriflora root extract according to the present invention on the expression of key antioxidant genes in melanocytes. [Figure 5] FIG. 1 is a graph showing the effect of the Neoporhiza croflora root extract according to the present invention on ROS in dermal papilla cells. [Figure 6] FIG. 1 is a graph showing the effect of the Neoporhiza croflora root extract according to the present invention on tyrosinase activity. [Figure 7] FIG. 1 is a graph showing the effect of the Neoporhiza croflora root extract according to the present invention on the amount of melanin produced. [Figure 8] FIG. 1 is a graph showing the effect of the European larch extract according to the present invention on the amount of melanin produced in hair follicles. [Figure 9] FIG. 1 is a graph showing the effect of a black hair regeneration essence according to an embodiment of the present invention on the amount of melanin produced in shed white hair follicles. [Figure 10] 1 is an image of shed gray hair follicles treated with a black hair regrowth essence according to an embodiment of the present invention. [Figure 11] FIG. 1 shows the change in the percentage of gray hair after human test volunteers used the black hair regrowth essence of Example 1. [Figure 12] FIG. 1 shows the effects of human test volunteers after using the black hair regrowth essence of Example 1. [Figure 13] FIG. 1 shows the effects of human test volunteers after using the black hair regrowth essence of Example 1. [Figure 14] FIG. 1 shows the effects of human test volunteers after using the black hair regrowth essence of Example 1. [Figure 15] FIG. 1 shows the effects of human test volunteers after using the black hair regrowth essence of Example 1. [Figure 16] FIG. 1 shows the effects of human test volunteers after using the black hair regrowth essence of Example 1. [Figure 17] FIG. 1 shows a quantitative analysis of gray hair density after human test volunteers used the black hair regrowth essence of Example 1. [Figure 18] FIG. 1 shows the effect of gray hair density after human test volunteers used the black hair regrowth essence of Example 1. DETAILED DESCRIPTION OF THE INVENTION

[0022] DETAILED DESCRIPTION OF THE INVENTION The present invention will now be described in detail with reference to specific embodiments, in order to enable those skilled in the art to better understand and practice the technical solutions of the present invention. Example 1

[0023] Black hair regeneration essence contains the following ingredients:

[0024] [Table 1]

[0025] The method for producing the black hair regeneration essence is as follows: (1) Mix pentylene glycol and concentrated glycerin and stir until uniform to obtain Preparation A. Mix menthol, PEG-40 hydrogenated castor oil, and Tween-20, heat to 40-50°C, stir to dissolve, and cool to obtain Preparation B. (2) Add water, disodium EDTA, dipotassium glycyrrhizinate, and xanthan gum to a suitable container and stir to dissolve. Heat to 60-75°C, add Preparation A, and stir until completely dissolved. (3) Add the following ingredients in the order listed: spinach extract, sesame seed extract, Polygonum multiflorum extract, hydrolyzed flax seed extract, Neoporhiza croflora root extract, acetyl tyrosine, and European larch extract. Stir until completely dissolved and transparent. (4) Add citric acid and sodium citrate, stir to dissolve, and adjust the pH to 4.0-5.0. (5) Add Preparation B and preservative, stir to dissolve, and cool to below 30°C. Example 2

[0026] Black hair regeneration essence contains the following ingredients:

[0027] [Table 2]

[0028] The method for producing the black hair regeneration essence is as follows: (1) Mix pentylene glycol and concentrated glycerin and stir until uniform to obtain Preparation A. Mix menthol, PEG-40 hydrogenated castor oil, and Tween-20, heat to 40-50°C, stir to dissolve, and cool to obtain Preparation B. (2) Add water, disodium EDTA, dipotassium glycyrrhizinate, and xanthan gum to a suitable container and stir to dissolve. Heat to 60-75°C, add Preparation A, and stir until completely dissolved. (3) Add the following ingredients in the order listed: spinach extract, sesame seed extract, Polygonum multiflorum extract, hydrolyzed flax seed extract, Neoporhiza croflora root extract, acetyl tyrosine, and European larch extract. Stir until completely dissolved and transparent. (4) Add citric acid and sodium citrate, stir to dissolve, and adjust the pH to 4.0-5.0. (5) Add Preparation B and preservative, stir to dissolve, and cool to below 30°C. Example 3

[0029] Black hair regeneration essence contains the following ingredients:

[0030] [Table 3]

[0031] The method for producing the black hair regeneration essence is as follows: (1) Mix pentylene glycol and concentrated glycerin and stir until uniform to obtain Preparation A. Mix menthol, PEG-40 hydrogenated castor oil, and Tween-20, heat to 40-50°C, stir to dissolve, and cool to obtain Preparation B. (2) Add water, disodium EDTA, dipotassium glycyrrhizinate, and xanthan gum to a suitable container and stir to dissolve. Heat to 60-75°C, add Preparation A, and stir until completely dissolved. (3) Add the following ingredients in the order listed: spinach extract, sesame seed extract, Polygonum multiflorum extract, hydrolyzed flax seed extract, Neoporhiza croflora root extract, acetyl tyrosine, and European larch extract. Stir until completely dissolved and transparent. (4) Add citric acid and sodium citrate, stir to dissolve, and adjust the pH to 4.0-5.0. (5) Add Preparation B and preservative, stir to dissolve, and cool to below 30°C. Example 4

[0032] Black hair regeneration essence contains the following ingredients:

[0033] [Table 4]

[0034] The method for producing the black hair regeneration essence is as follows: (1) Mix pentylene glycol and concentrated glycerin and stir until uniform to obtain Preparation A. Mix menthol, PEG-40 hydrogenated castor oil, and Tween-20, heat to 40-50°C, stir to dissolve, and cool to obtain Preparation B. (2) Add water, disodium EDTA, dipotassium glycyrrhizinate, and xanthan gum to a suitable container and stir to dissolve. Heat to 60-75°C, add Preparation A, and stir until completely dissolved. (3) Add the following ingredients in the order listed: spinach extract, sesame seed extract, Polygonum multiflorum extract, hydrolyzed flax seed extract, Neoporhiza croflora root extract, acetyl tyrosine, and European larch extract. Stir until completely dissolved and transparent. (4) Add citric acid and sodium citrate, stir to dissolve, and adjust the pH to 4.0-5.0. (5) Add Preparation B and preservative, stir to dissolve, and cool to below 30°C. (Performance test)

[0035] The hydrolyzed flaxseed extract of the present invention helps maintain and restore the original color of hair by: 1) significantly increasing the level of tyrosinase, the rate-limiting enzyme that initiates melanin production in melanocytes, as shown in Figure 1; 2) increasing the expression of all protein markers, including TPR-1, MITF, Pmel17, and c-Kit, as shown in Figure 2. TPR-1 is a key protein involved in melanin synthesis in human melanocytes, MITF contributes to melanin synthesis in human melanocytes, Pmel17 favors melanin storage in human melanocytes, and c-Kit controls the melanin process in human melanocytes; and 3) significantly increasing the expression of PAR-2 ​​in keratinocytes, promoting the transport of melanin from melanocytes to keratinocytes, as shown in Figure 3.

[0036] The Neoporhiza chloriflora root extract of the present invention contains an iridoid glycoside called picroside II and polyphenols, which possess anti-apoptotic, anti-inflammatory, and antioxidant properties, making it highly effective in restoring gray hair to black. 1) As shown in Figure 4, it increased the expression of key antioxidant genes in melanocytes, preventing oxidative stress, improving antioxidant properties, and inhibiting hair graying. 2) Hair follicle dermal papilla cells play an important role in regulating active melanocyte regeneration, and reactive oxygen species (ROS) in the cells can affect their activity. As shown in Figure 5, Neoporhiza chloriflora root extract reduced ROS production in hair papilla cells, inhibiting environmental oxidative stress and improving hair coloration. 3) As shown in Figure 6, it promoted tyrosinase activity and increased pigmentation. 4) As shown in Figure 7, it promoted melanin production and reversed hair pigment loss.

[0037] The test method for the effect of Neoporhiza chrofraliflora root extract on the expression of antioxidant genes in melanocytes was as follows: melanocytes were cultured with 1.0% Neoporhiza chrofraliflora root extract for 48 hours, and oxidative stress was detected after 24 hours; that is, the cells were divided into two parts, one part was treated with 250 μm H2O2 for 2 hours, and the other part was not treated, and the mRNA expression of NRF2, HMOX1, and SLC7A11 genes was detected using RT-qPCR on the mixed culture triploids.

[0038] The effect of Neoporhiza chloriflora root extract on melanocyte ROS content was tested as follows. Hair follicle dermal papilla cells play an important role in regulating active melanocyte regeneration. The accumulation of ROS in cells affects their activity, and reducing ROS production can improve hair color. Human dermal papilla cells (HFDPCs) were cultured with a black hair regeneration composition for 24 hours, then exposed to oxidative stress (250 μm H2O2) within 30 minutes. Finally, intracellular ROS was measured using a fluorescent probe (2,7-HFDPC-DA). The results showed that treatment with different concentrations of Neoporhiza chloriflora root extract effectively reduced ROS production.

[0039] The test method for the effect of Neoporhiza chrofraliflora root extract on tyrosinase activity was as follows: melanocytes were cultured with Neoporhiza chrofraliflora root extract for 72 hours (n=3), and oxidative stress was detected after 72 hours by treating with 5M H2O2 for 30 minutes, incubating with L-DOPA substrate, and then evaluating the enzyme activity by optical density (OD) at 540 nm.

[0040] The test method for the effect of Neoporhiza chrofraliflora root extract on melanin production was as follows: melanocytes and keratinocytes were co-cultured with Neoporhiza chrofraliflora root extract or L-tyrosine for 10 days, and oxidative stress was measured on days 0, 3, and 7. That is, they were treated with 250 μm H2O2 for 2 hours, and the melanin content of the cells was evaluated by optical density (OD) at 405 nm (n=3).

[0041] In the present invention, European larch extract stimulates the production of melanin in gray hair, and as shown in Figure 8, the results of in vitro tests showed a significant increase of 66% in melanin production in hair follicles within 3 days.

[0042] The in vitro test method for European larch extract involves treating hair follicles in the early stages of hair growth with different concentrations of European larch extract for 72 hours, and evaluating melanin production using the Fontana Masson staining method and image analysis.

[0043] 1. In vitro experiment to measure melanin production in gray hair As shown in Figures 9 and 10, early stage white hair follicles from two donors were treated with or without black hair regeneration essence containing 1% of the black hair regeneration composition of Example 1 for 72 hours, and were evaluated using Fontana Masson staining (black in Figure 2) and image analysis to quantify the melanin content in the hair follicles. Results: 1% of the black hair regeneration composition significantly increased melanin production in hair follicles by 15% within 3 days.

[0044] 2. Experiment to reduce the percentage of gray hair The first group of volunteers used a placebo, and the second group of volunteers used a black hair regeneration essence containing 1% of the black hair regeneration composition of Example 1 once a day for four months, and the proportion of gray hair was evaluated. Results: As shown in Figure 11, after 4 months, the black hair regrowth composition significantly reduced the rate of gray hair by 17%, 2.1 times that of the placebo group. Figures 12 to 16 show the effects of human test volunteers: Figure 12 is a 24-year-old woman, Figure 13 is a 46-year-old man, Figure 14 is a 35-year-old man, and Figure 15 is a 44-year-old woman.

[0045] 3. Quantitative analysis of gray hair density Volunteers in Group 1 received a placebo, while volunteers in Group 2 used a hair conditioner containing 1% of the black hair regrowth composition once daily for four months, and the percentage of gray hair was assessed. Results: As shown in Figures 17 and 18, after 4 months, the black hair regrowth composition significantly reduced the number of gray hairs per square centimeter, with an average reduction of 6.8 hairs, 3.4 times that of the placebo group.

[0046] Although the above examples have described in detail various implementation processes of the present invention, the embodiments of the present invention are not limited thereto, and those skilled in the art can achieve the objectives of the present invention based on the contents disclosed in the present invention. All improvements and modifications made based on the concept of the present invention fall within the protection scope of the present invention, and the specific protection scope is set forth in the claims.

Claims

1. A black hair regeneration essence characterized by comprising a black hair regeneration composition containing, relative to the total amount of the black hair regeneration essence, 0.010% by mass to 1.0% by mass of canola extract, 0.010% by mass to 0.5% by mass of sesame seed extract, 0.414% by mass of Polygonum polyosmodium extract, 0.0010% by mass to 0.20% by mass of hydrolyzed linseed extract, 0.00010% by mass to 0.20% by mass of Neoporhiza chrysanthemum var. chrysanthemum extract, 0.0100% by mass to 0.45% by mass of acetyl tyrosine, and 0.0010% by mass to 0.15% by mass of European larch extract.

2. The black hair regrowth essence according to claim 1, further comprising 0.5% to 10% by mass of an auxiliary agent based on the total amount of the black hair regrowth essence.

3. 3. The black hair regrowth essence according to claim 2, wherein the auxiliary agent comprises one or more of a conditioning agent and a preservative.

4. 4. The black hair regrowth essence according to claim 3, wherein the conditioning agent is one or more of glycerin, pentylene glycol, PEG-40 hydrogenated castor oil, menthol, and dipotassium glycyrrhizinate.

5. The black hair regeneration essence according to claim 4, wherein the auxiliary further comprises a thickener, a pH stabilizer, and a chelating stabilizer.

6. 6. The black hair regrowth essence according to claim 5, wherein the thickener is xanthan gum, the pH stabilizer is anhydrous citric acid and sodium citrate, and the chelating stabilizer is disodium EDTA.

7. 7. The black hair regrowth essence according to claim 6, comprising 0.3% by weight of Rhizome extract, 0.05% by weight of sesame seed extract, 0.414% by weight of Polygonum multiflorum extract, 0.0055% by weight of hydrolyzed linseed extract, 0.0005% by weight of Neoporhiza croflora root extract, 0.17% by weight of acetyl tyrosine, 0.06% by weight of European larch extract, 3% by weight of pentylene glycol, 3% by weight of glycerin, 0.05% by weight of disodium EDTA, 0.2% by weight of xanthan gum, 0.2% by weight of sodium citrate, 0.12% by weight of citric acid, 0.2% by weight of dipotassium glycyrrhizinate, 0.2% by weight of menthol, and 1.0% by weight of PEG-40 hydrogenated castor oil.

8. A method for producing the black hair regeneration essence according to any one of claims 1 to 7, (1) mixing pentylene glycol, glycerin, disodium EDTA, xanthan gum, and dipotassium glycyrrhizinate in predetermined amounts and dissolving them into a transparent solution to obtain Preparation A, and then mixing menthol, PEG-40 hydrogenated castor oil, and Tween-20, stirring, and dissolving the mixture to obtain Preparation B; (2) A method for producing a black hair regrowth essence, comprising the steps of: (1) adding to Preparation A, in this order, watercress extract, sesame seed extract, Polygonum multiflorum extract, hydrolyzed flax seed extract, Neoporhiza croflora root extract, acetyl tyrosine, and European larch extract; after dissolving, adding sodium citrate / citric acid to adjust the pH to 4.5 to 5.0; adding Preparation B; stirring and cooling; and obtaining a black hair regrowth essence.

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