Oral components

Abstract

To provide an oral composition that exhibits excellent dispersibility in the mouth even after its storage, also has a good taste, and contains water-soluble aluminum salt or potassium salt.SOLUTION: An oral composition contains (A) at least one selected from water-soluble aluminum salt and potassium salt, (B) tin-containing compound, and (C) granules. The oral composition may also contain (D) a cold sensing agent.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oral composition containing a water-soluble aluminum salt and / or a water-soluble potassium salt, which has excellent dispersibility in the mouth even after storage and a good taste. [Background technology]

[0002] Conventionally, water-soluble aluminum salts and water-soluble potassium salts have been used in oral compositions as active ingredients for preventing or suppressing dentin hypersensitivity, and in particular, aluminum lactate as a water-soluble aluminum salt and potassium nitrate as a water-soluble potassium salt have been commonly used as ingredients for preventing or suppressing dentin hypersensitivity (Patent Documents 1 to 3: JP 2010-222325 A, JP 5-155745 A, JP 11-510161 A). Furthermore, it has been proposed that tin-containing compounds have a basic function of preventing or inhibiting dental caries, and that drugs containing tin ions are effective as antibacterial agents (Patent Document 4: JP 2008-143910 A). By adding a tin-containing compound to an oral composition containing a water-soluble aluminum salt or potassium salt, these effects can be simultaneously imparted, and improved effects can be expected. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2010-222325 [Patent Document 2] Japanese Patent Application Publication No. 5-155745 [Patent Document 3] Special Publication No. 11-510161 [Patent Document 4] Japanese Patent Application Laid-Open No. 2008-143910 Summary of the Invention [Problem to be solved by the invention]

[0004] However, when a tin-containing compound is added to an oral composition containing a water-soluble aluminum salt or potassium salt, the formulation hardens over time, resulting in problems such as poor dispersibility in the mouth. Furthermore, the aluminum salts and potassium salts themselves can have an unpleasant taste such as a metallic taste, and adding a tin-containing compound with a metallic taste could lead to a deterioration in the taste and other aspects of the experience when used.

[0005] The present invention has been made in consideration of the above circumstances, and aims to provide an oral composition containing a water-soluble aluminum salt and / or a water-soluble potassium salt, which has excellent dispersibility in the mouth even after storage and a good taste. [Means for solving the problem]

[0006]

[0006] As a result of extensive research to achieve the above object, the present inventors have found that when an oral composition containing a water-soluble aluminum salt and / or a water-soluble potassium salt is combined with a tin-containing compound and granules, particularly silica granules, the formulation remains stable without hardening over time, and the granules physically aid in the dispersion of the formulation in the mouth during use, resulting in excellent dispersibility of the formulation even after storage and use in the mouth, an improved astringent taste, and a pleasant taste. Specifically, the present invention has been made based on the discovery that an oral composition containing (A) one or more water-soluble aluminum salts and potassium salts, (B) a tin-containing compound, and (C) granules exhibits the effects of components (A) and (B), such as preventing or suppressing tooth hypersensitivity and caries, and also exhibits excellent dispersibility in the mouth even after storage and provides a pleasant taste when used.

[0007] More specifically, when an oral composition containing component (A) having a preventive or suppressive effect on tooth hypersensitivity is combined with component (B) having a preventive or suppressive effect on dental caries, the formulation hardens over time, and the formulation becomes poorly dispersible when used in the mouth. In particular, in the case of dentifrice compositions such as toothpaste, the paste hardens after storage, leaving lumps of paste upon brushing that do not disperse evenly in the mouth, causing a sticky feeling, and the components (A) and (B) have a very strong metallic or other unpleasant taste that is perceived as a strong, unpleasant, acrid taste, resulting in a poor taste. However, when component (C) is further added in combination, in a combined system of components (A) and (B), component (C) prevents the formulation from hardening over time, physically aids in the dispersion of the formulation in the mouth when used, and even in the case of toothpaste, physically aids in the dispersion of the paste when brushing, thereby improving dispersibility in the mouth, particularly after storage, and masking and improving the harsh taste, thereby achieving the unexpected effect. Furthermore, although granules can exhibit a harsh taste (astringency) when used in large quantities, in the present invention, the above-mentioned exceptional effect can be imparted by adding component (C) in a preferably specific amount. Furthermore, in the present invention, when granules having a particular particle size and disintegration strength are blended as component (C), the above-mentioned effects can be made even more excellent.

[0008] Therefore, the present invention provides the following oral compositions. [1] (A) one or more water-soluble aluminum salts and potassium salts; (B) Tin-containing compounds and (C) Granules An oral composition comprising: [2] The oral composition according to [1], wherein the water-soluble aluminum salt is aluminum lactate and the water-soluble potassium salt is potassium nitrate. [3] (B) The oral composition according to [1] or [2], wherein the tin-containing compound is one or more selected from tin chloride, tin fluoride, tin acetate, tin gluconate, tin oxalate, tin sulfate, tin lactate, tin tartrate, tin citrate, tin malate, sodium stannate, and tin phosphate. [4] (C) The oral composition according to any one of [1] to [3], wherein the granules have an average disintegration strength of 10 to 100 g per granule. [5] (C) An oral composition according to any one of [1] to [4], wherein the granules contain granules having a particle size of 53 to 850 μm, and the content of the granules having a particle size of 53 to 850 μm relative to the total composition is 0.1 to 15 mass%. [6] (C) The oral composition according to any one of [1] to [5], wherein the granules have an average particle size (D50: by mass) of 60 to 500 μm. [7] (C) The oral composition according to any one of [1] to [6], wherein the granules are silica granules. [8] The oral composition according to any one of [1] to [7], wherein the content of the water-soluble aluminum salt is 0.01 to 1 mass% in terms of aluminum ions, and the content of the water-soluble potassium salt is 0.05 to 4 mass% in terms of potassium ions. [9] (B) The oral composition according to any one of [1] to [8], wherein the content of the tin-containing compound is 0.02 to 1 mass % in terms of tin ions.

[10] An oral composition according to any one of [1] to [9], wherein (B) / (C), which represents the ratio of the content of component (B) as tin ions to the content of component (C), is 0.03 to 3 in mass ratio.

[11] The oral composition according to any one of [1] to

[10] , further comprising 0.00001 to 0.01 mass % of a cooling agent (D).

[12] The oral composition according to

[11] , wherein (D) the cooling agent is one or more selected from N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate, and menthyl succinate.

[13] The oral composition according to any one of [1] to

[12] , which is a toothpaste or a gel-type toothpaste. [Effects of the Invention]

[0009] According to the present invention, an oral composition containing component (A) and component (B) can be provided, which has excellent dispersibility in the mouth even after storage, a pleasant taste with reduced harshness, etc. This oral composition has the effects of preventing or suppressing tooth hypersensitivity and dental caries due to components (A) and (B), and is effective for preventing or suppressing periodontal diseases. DETAILED DESCRIPTION OF THE INVENTION

[0010] The present invention will be described in further detail below. The oral composition of the present invention contains (A) a water-soluble aluminum salt and / or a water-soluble potassium salt, (B) a tin-containing compound, and (C) granules.

[0011] Component (A) is a water-soluble aluminum salt and / or a water-soluble potassium salt. The aluminum salt has a dentinal tubule sealing effect, and the potassium salt has a dentinal tubule denervation effect, and these are particularly effective as components for preventing or suppressing hypersensitivity. Examples of water-soluble aluminum salts include aluminum lactate, aluminum tartrate, aluminum citrate, aluminum gluconate, aluminum glycolate, aluminum malonate, aluminum glutarate, aluminum malate, aluminum chloride, aluminum sulfate, aluminum potassium sulfate, and allantoin dihydroxyaluminum, with aluminum lactate being particularly preferred. Examples of water-soluble potassium salts include potassium nitrate, potassium chloride, monopotassium phosphate, dipotassium phosphate, tripotassium phosphate, potassium pyrophosphate, potassium tripolyphosphate, potassium hydroxide, potassium carbonate, potassium hydrogencarbonate, potassium aluminum sulfate, potassium sulfate, potassium lactate, potassium oxalate, potassium sorbate, monopotassium citrate, potassium hydrogen tartrate, potassium sodium tartrate, potassium gluconate, potassium glutamate, potassium succinate, potassium malate, dipotassium glycyrrhizinate, acesulfame potassium, and potassium fluoride, with potassium nitrate being particularly preferred. These may be used alone or in combination of two or more, and commercially available products may also be used.

[0012] The amount of component (A) to be blended is preferably adjusted depending on the substance to be used, and the amounts of the water-soluble aluminum salt and water-soluble potassium salt to be blended are preferably within the following ranges, respectively. When a water-soluble aluminum salt is used as component (A), its amount is preferably 0.01 to 1% (mass %, hereinafter the same) of the total composition in terms of aluminum ions, more preferably 0.05 to 0.5%. The greater the amount, the greater the effect of preventing or suppressing hypersensitivity. However, if the amount is 1% or less, dispersibility in the mouth and astringency are sufficiently improved. When a water-soluble potassium salt is used as component (A), its amount is preferably 0.05 to 4%, more preferably 0.5 to 3%, of the total composition in terms of potassium ions. The greater the amount, the greater the effect of preventing or suppressing hypersensitivity. However, if the amount is 4% or less, dispersibility in the mouth and the harsh taste are sufficiently improved. Furthermore, the blending amount of component (A), as the total blending amount of aluminum ions and potassium ions, is preferably 0.01 to 5% of the entire composition, more preferably 0.05 to 4%. Within this range, the effect of preventing or suppressing tooth hypersensitivity is exerted, and dispersibility in the mouth and astringency are sufficiently improved.

[0013] (B) The tin-containing compound has a caries prevention or suppression effect and is effective as a caries prevention or suppression component. Examples of tin-containing compounds include tin chloride, tin fluoride, tin acetate, tin gluconate, tin oxalate, tin sulfate, tin lactate, tin tartrate, tin citrate, tin malate, sodium stannate, tin phosphate, etc. Tin chloride and tin fluoride are particularly preferred. As the tin chloride, tin(II) chloride (stannous chloride) can be used, and a hydrate such as tin(II) chloride dihydrate can also be used. As the tin fluoride, tin(II) fluoride (stannous fluoride) or tin(IV) fluoride (stannic fluoride) can be used. In particular, tin(II) fluoride (stannous fluoride) is preferred because it can provide a caries prevention effect. These may be used alone or in combination of two or more, and commercially available products may also be used.

[0014] The amount of the tin-containing compound (B) is preferably 0.02 to 1% of the total composition in terms of tin ions, more preferably 0.1 to 0.6%. The greater the amount of tin ions, the greater the caries prevention or inhibition effect. However, if the amount is 1% or less, dispersibility in the mouth and astringency are sufficiently improved.

[0015] (C) Granules are a combination of components (A) and (B), which prevent the formulation from hardening over time, improve dispersibility in the mouth, especially after storage, and also mask and improve the harsh taste. (C) Granules preferably have the following physical properties. Granules using water-insoluble powders for dentifrices having these properties, such as silica granules, zeolite granules, calcium carbonate granules, aluminum hydroxide granules, calcium bicarbonate granules, etc., can be used, with silica granules being particularly preferred.

[0016] (C) The granules are preferably disintegrating granules, and the average disintegration strength thereof is *1 is preferably 10 to 100 g / piece, more preferably 15 to 50 g / piece. When it is 10 g / piece or more, particularly excellent dispersibility in the mouth can be imparted, and when it is 100 g / piece or less, it is preferable in terms of improving the harsh taste. *1:Average collapse strength The average value of the automatic breaking strength measurement (the load at which a granule collapses when compressed at a rate of 10 mm / min) for each of 30 granules was measured using a rheometer (Sun Rheometer CR-200D manufactured by Sun Scientific Co., Ltd.) (same below).

[0017] Furthermore, when the (C) granules were sieved using test sieves (850 μm, 500 μm, 355 μm, 300 μm, 250 μm, 180 μm, 125 μm, 90 μm, 63 μm, 53 μm, 45 μm) specified in JIS Z8801-1, (c1) Particles that do not pass through 850 μm (850 μm on) (c2) The sum of particles that pass through 850 μm and do not pass through 250 μm (850 μm pass~250 μm on) (c3) The sum of particles that pass through 250 μm and do not pass through 53 μm (250 μm pass~53 μm on) (c4) Particles that pass through 53 μm but not 45 μm (53 μm pass 45 μm on) As the powder, it is preferable that the powder contains granules having a particle size of 53 to 850 μm, that is, (c2) and (c3). Furthermore, the total amount of granules having a particle size of 53 to 850 μm contained in the granules, i.e., (c2) + (c3), is preferably 0.1 to 15%, more preferably 0.4 to 10%, of the total composition, which is even more preferable in terms of dispersibility in the mouth and improvement of a harsh taste. Furthermore, {(c2)+(c3)} / {(c1)+(c2)+(c3)+(c4)}, which indicates the ratio between the total amount of (c2)+(c3) and the total amount of (c1)+(c2)+(c3)+(c4), is preferably 0.7 or more, more preferably 0.8 or more, and particularly preferably 0.9 or more, by mass, and may be 1. (C) Granules that satisfy the above conditions are suitable for dispersibility in the mouth and for improving astringency. In particular, particles with a particle size of 53 μm or more have excellent dispersibility in the mouth, and particles with a particle size of 850 μm or less are suitable for improving astringency.

[0018] The (C) granules preferably have the following average particle size (D50: mass basis). Average particle size *2 is preferably 60 to 500 μm, more preferably 60 to 350 μm, and particularly preferably 80 to 200 μm. When the particle size is 60 μm or more, particularly excellent dispersibility in the mouth can be imparted, and when the particle size is 500 μm or less, it is preferable in terms of improving a harsh taste. *2: Average particle diameter (C) The average particle size of the granules is the value of the 50% cumulative particle size calculated from the mass-based particle size distribution, which is calculated by sieving the granules through JIS sieves (850 μm, 500 μm, 355 μm, 300 μm, 250 μm, 180 μm, 125 μm, 90 μm, 63 μm, 53 μm, 45 μm) and measuring the mass of the granules remaining on each sieve, with the opening of each sieve being the representative diameter (the same applies below). Among the above physical properties, (C) granules are particularly preferable if they are disintegrative silica granules having the above specific particle size, in terms of dispersibility in the mouth and improvement of harsh taste.

[0019] (C) Granules may be commercially available. Specific examples of silica granules having the above physical properties include "SORBOSIL BFG10" and "SORBOSIL BFG50" manufactured by PQ Corporation, "NIPGEL BY-001" manufactured by Tosoh Silica Corporation, and "Zeodent 9175" manufactured by HUBER.

[0020] The amount of (C) granules is preferably 0.1 to 15% of the total composition, more preferably 0.4 to 10%. When the amount is 0.1% or more, dispersibility in the mouth and astringency are sufficiently improved, and when it is 15% or less, the astringency (stringency) of the granules themselves is suppressed and the astringency is sufficiently improved. As mentioned above, it is particularly preferable to blend the (C) granules so that the total amount of granules with a particle size of 53 to 850 μm contained in the (C) granules, i.e., the total amount of (c2) + (c3), is within the above-mentioned specific range relative to the total amount of the composition, in terms of dispersibility in the mouth and improvement of the harsh taste.

[0021] In the present invention, the ratio (B) / (C), which represents the ratio of the content of component (B) as tin ions to the content of component (C), is preferably 0.03 to 3 by mass, more preferably 0.04 to 1. Within this range, dispersibility in the mouth is better and the astringent taste is further improved. If the mass ratio (B) / (C) is less than 0.03, the astringent taste (stringency) of component (C) may be too strong, impairing the feel in use. If it exceeds 3, dispersibility in the mouth and the astringent taste may not be improved satisfactorily. Furthermore, the ratio of the content of component (B) as tin ions to the total content of (c2) and (c3) contained in component (C), (B) / {(c2)+(c3)}, is preferably a mass ratio of 0.03 to 3, more preferably 0.04 to 1. When the mass ratio of (B) / {(c2)+(c3)} is within the above range, dispersibility in the mouth is further improved, and the harsh taste is further alleviated.

[0022] The oral composition of the present invention preferably further contains a cooling agent (D), which can further improve the harsh taste. Examples of (D) cooling agents include N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate, and menthyl succinate. Of these, N-(4-cyanomethylphenyl)-p-menthanecarboxamide and N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide) are preferred. These may be used alone or in combination of two or more.

[0023] Specifically, the cooling agent (D) may be any of the commercially available products listed below. N-Ethyl-p-menthane-3-carboxamide; Symrise, WS-3 Ethyl 3-(p-menthane-carboxamido) acetate; Toyotama Fragrance Co., Ltd., WS-5 N-(4-cyanomethylphenyl)-p-menthanecarboxamide: EVERCOOL 180, manufactured by Givaudan Japan Co., Ltd. N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide; EVERCOOL 190, manufactured by Givaudan Japan Co., Ltd. 2-Isopropyl-N,2,3-trimethylbutyramide; Givaudan Japan Co., Ltd., WS-23 Menthone glycerol acetal; Symrise, MGA Menthoxypropane-1,2-diol; Takasago International Corporation, CA10 Menthyl lactate; manufactured by Symrise Menthyl succinate (monomenthyl succinate); manufactured by Vimanfis

[0024] When component (D) is blended, the blend amount is preferably 0.00001 to 0.01%, and more preferably 0.00003 to 0.002%, of the total composition.

[0025] The oral composition of the present invention can be used by preparing it into a dentifrice such as toothpaste, gel toothpaste, etc., particularly in the form of a paste or gel. Conventional methods can be used as the preparation method depending on the form and dosage form. In this case, other appropriate optional components in addition to the above-mentioned components can be blended as needed depending on the purpose, dosage form, etc. Examples of optional components include surfactants, abrasives, thickeners, humectants, solvents, sweeteners, flavorings, preservatives, colorants, active ingredients, etc. Specific examples of optional components are shown below. These optional components can be blended singly or in combination of two or more, and the blend amount of each optional component can be a normal amount within a range that does not impair the effects of the present invention.

[0026] Examples of surfactants include anionic surfactants, nonionic surfactants, and amphoteric surfactants, and specific examples thereof are shown in (i) to (iii) below. (i) Anionic surfactants Examples of the salts include alkyl sulfates such as lauryl sulfate, acyl sarcosine salts, acyl methyl taurine salts, acyl glutamates, and α-olefin sulfonates (tetradecene sulfonates), and alkali metal salts such as sodium salts and potassium salts are preferred. (ii) Nonionic surfactants Examples of the oils include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, sorbitan fatty acid ester, and fatty acid monoglyceride. (iii) amphoteric surfactants Examples thereof include fatty acid amidopropyl betaines such as coconut oil fatty acid amidopropyl betaine, and N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salts. The amount of surfactant to be added is preferably 0.001 to 10%, and more preferably 0.1 to 5%, of the total composition.

[0027] Abrasives other than (C) granules may be used. Examples of abrasives include silica-based abrasives such as anhydrous silicic acid, precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica; calcium phosphate-based abrasives such as dibasic calcium phosphate dihydrate or anhydrous calcium phosphate, monobasic calcium phosphate, tribasic calcium phosphate, and calcium pyrophosphate; calcium carbonate-based abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, and hydroxyapatite; and one or more of these may be blended. Silica-based abrasives generally have an average particle size (D50, volume basis) of less than 30 μm as measured by laser diffraction, and even if they contain particles with a particle size of 53 μm or more, the amount contained is very small. The amount of the abrasive blended is usually 2 to 50%, particularly 10 to 40%, of the entire composition.

[0028] Examples of thickeners include organic thickeners such as xanthan gum, sodium alginate, hydroxyethyl cellulose, carrageenan, sodium carboxymethyl cellulose, polyvinylpyrrolidone, sodium polyacrylate, cationized cellulose, and carboxyvinyl polymer, and inorganic thickeners such as thickening silica. The amount of thickener blended is usually 0.1 to 10%, and particularly 0.1 to 8%, of the total composition. Inorganic thickeners generally have an average particle size (D50, volume basis) of less than 30 μm as measured by laser diffraction using a Microtrac particle size analyzer or the like, and even if they contain particles with a particle size of 53 μm or more, the amount contained is very small.

[0029] Examples of the humectant include sugar alcohols such as sorbitol, xylitol, and erythritol, and polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol (PEG). The amount of the humectant blended is usually 2 to 50% of the total composition.

[0030] Examples of the solvent include purified water and lower alcohols having 1 to 3 carbon atoms, such as ethanol. When ethanol is added, it may be present in an amount of 25% or less of the total composition, or it may not be added at all.

[0031] Sweetening agents include saccharin, saccharin sodium, and sucralose.

[0032] Examples of fragrances include menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon bark oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, and eucalyptus oil, which can be used alone or in combination of two or more. The amount of fragrance blended is usually 0.01 to 2% of the total composition.

[0033] Examples of preservatives include parahydroxybenzoic acid esters and sodium benzoate. Examples of colorants include Blue No. 1, Blue No. 2, Green No. 3, Yellow No. 4, Yellow No. 5, Red No. 106, Red No. 227, caramel, titanium oxide, and titanium mica.

[0034] Optional active ingredients include fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, enzymes such as dextranase, allantoin, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, isopropylmethylphenol, copper gluconate, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, zeolite, calcium glycerophosphate, and Phellodendron Bark extract. [Example]

[0035] The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, % indicates % by mass unless otherwise specified.

[0036] [Examples and Comparative Examples] Oral compositions (toothpastes) having the compositions shown in Tables 1 and 2 were prepared by conventional methods and evaluated by the following methods. The results are also shown in the tables. All of the oral compositions of the Examples had the effect of preventing or suppressing tooth hypersensitivity and the effect of preventing or suppressing caries.

[0037] (1) Dispersibility in the mouth over time (dispersibility in the mouth immediately after use, dispersibility in the mouth after storage) Ten expert panelists squeezed out approximately 1 g of toothpaste onto a toothbrush, placed it 1 cm deep, and brushed their teeth in the same way as usual, and evaluated the dispersibility of the paste in the mouth while brushing using the following evaluation criteria. For the evaluation, toothpaste immediately after production and toothpaste stored at 40°C for one month were used, and the dispersibility in the mouth of the product immediately after production and the product after storage was evaluated based on the state of the paste in the mouth 10 seconds after the start of brushing. Evaluation criteria 4 points: Very good dispersibility in the mouth (no lumps of dough remain) 3 points: Good dispersibility in the mouth (there are some areas that are slightly unevenly kneaded, but this is not noticeable) 2 points: Poor dispersibility in the mouth (lumps of dough remain in the mouth) 1 point: Very poor dispersibility in the mouth (large lumps of paste remain) The results of evaluation by 10 expert panelists were averaged and judged according to the following criteria. Judgment criteria ◎: Average score 3.5 points or more ○: Average score 3.0 points or more and less than 3.5 points △: Average score 2.0 points or more and less than 3.0 points ×: Average score less than 2.0 points

[0038] (2) Bitter taste A sensory evaluation was performed by a panel of 10 expert subjects. The toothpaste packed in a laminated tube was squeezed out 1 cm onto the toothbrush, and the subject brushed their teeth in the usual way. After rinsing with water, the bitter taste remaining in the mouth after 5 minutes was evaluated using the following evaluation criteria. Evaluation criteria: 4 points: No bitter taste at all 3 points: Slightly bitter taste 2 points: A bitter taste 1 point: Very strong bitter taste The results of evaluation by 10 expert panelists were averaged and judged according to the following criteria. Judgment criteria ☆: Average score 4.0 points ◎: Average score 3.5 points or more and less than 4.0 points ○: Average score 3.0 points or more and less than 3.5 points △: Average score 2.0 points or more and less than 3.0 points ×: Average score 1.0 or more and less than 2.0 points

[0039] Details of the raw materials used are shown below. (A) Aluminum lactate; Fujifilm Wako Pure Chemical Industries, Ltd., Aluminum lactate (A) Potassium nitrate; manufactured by Otsuka Chemical Co., Ltd., potassium nitrate (B) Tin chloride: Tin(II) chloride dihydrate, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. (B) Tin fluoride: Tin(II) fluoride, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. (C) Silica Granules A; SORBOSIL BFG10 manufactured by PQ Corporation (Particle size distribution (using test sieves specified in JIS Z8801-1): {(c2)+(c3)} / {(c1)+(c2)+(c3)+(c4)}=0.99, 850μm on is none, 45μm pass is slight (less than 0.1%), average collapse strength *1 :44g / piece, average particle size *2 :105μm) (C) Silica Granules B; SORBOSIL BFG50 manufactured by PQ Corporation (Particle size distribution (using test sieves specified in JIS Z8801-1): {(c2) + (c3)} / {(c1) + (c2) + (c3) + (c4)} = 0.99, 850 μm on is none, 45 μm pass is trace (less than 0.1%), average disintegration strength *1 :32g / piece, average particle size *2 :270μm) *1: Details of the measurement method for average disintegration strength, *2: average particle size, etc. are the same as those described above. Note that (c1), (c2), (c3), and (c4) are the same as those described above. (D) N-(4-cyanomethylphenyl)-p-menthanecarboxamide; Givaudan Japan Co., Ltd., Evercool 180 (D) N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide); Givaudan Japan Co., Ltd., Evercool 190 Silica (abrasive); EVONIC, ZEODENT103 (Particle size: Passes through a test sieve with an opening of 45 μm as specified in JIS Z8801-1, Average particle size (measured with a Microtrac particle size analyzer manufactured by Nikkiso Co., Ltd., D50, volume basis): 10μm) The details of the composition of fragrance A are as described below.

[0040] [Table 1]

[0041] [Table 2]

[0042] Composition of fragrance A; Peppermint oil 50 Peppermint refined oil (20% pre-distillate) 5 Peppermint refined oil (15% front and rear cut) 5 1 spearmint oil Spearmint refined oil (20% pre-distillate) 1 Japanese peppermint oil 1 Japanese mint refined oil (30% front distillate removed) 1 Menthol 10 Carvone 1 1,8-cineole 1 Anethole 5 Cinnamic aldehyde 1 Eugenol 1 Methyl Salicylate 1 Flavor 1 (Table 3) 1 Flavor 2 (Table 4) 1 Flavor 3 (Table 5) 1 Flavor 4 (Table 6) 1 Flavor 5 (Table 7) 1 Flavor 6 (Table 8) 1 Flavor 7 (Table 9) 1 Solvent (Table 10) Remaining Total 100%

[0043] [Table 3]

[0044] [Table 4]

[0045] [Table 5]

[0046] [Table 6]

[0047] [Table 7]

[0048] [Table 8]

[0049] Table 9

[0050] Table 10

Claims

1. (A) one or more water-soluble aluminum salts and potassium salts; (B) Tin-containing compounds and (C) Granules with a particle size of 53 to 850 μm wherein (B) / (C), which represents the ratio of the content of component (B) as tin ions to the content of component (C), is 0.03 to 3 in mass ratio.

2. 2. The oral composition according to claim 1, wherein the water-soluble aluminum salt is aluminum lactate and the water-soluble potassium salt is potassium nitrate.

3. 3. The oral composition according to claim 1 or 2, wherein (B) the tin-containing compound is one or more selected from tin chloride, tin fluoride, tin acetate, tin gluconate, tin oxalate, tin sulfate, tin lactate, tin tartrate, tin citrate, tin malate, sodium stannate, and tin phosphate.

4. 3. The oral composition according to claim 1, wherein the tin-containing compound (B) is one or two compounds selected from the group consisting of tin chloride and tin fluoride.

5. The oral composition according to any one of claims 1 to 4, wherein the granules (C) have an average disintegration strength of 10 to 100 g / granule.

6. An oral composition according to any one of claims 1 to 5, wherein the content of (C) granules having a particle size of 53 to 850 µm is 0.1 to 15 mass % of the total composition.

7. The oral composition according to any one of claims 1 to 6, wherein the granules (C) have an average particle size (D50: by mass) of 60 to 500 µm.

8. The oral composition according to any one of claims 1 to 7, wherein the granules (C) are silica granules.

9. An oral composition according to any one of claims 1 to 8, wherein the content of the water-soluble aluminum salt is 0.01 to 1 mass% in terms of aluminum ions, and the content of the water-soluble potassium salt is 0.05 to 4 mass% in terms of potassium ions.

10. The oral composition according to any one of claims 1 to 9, wherein the content of the tin-containing compound (B) is 0.02 to 1 mass % in terms of tin ions.

11. An oral composition according to any one of claims 1 to 9, wherein the content of (B) the tin-containing compound is 0.30 to 0.41 mass% in terms of tin ions.

12. An oral composition according to any one of claims 1 to 11, wherein (B) / (C), which represents the ratio of the content of component (B) as tin ions to the content of component (C), is 0.03 to 1 in mass ratio.

13. The oral composition according to any one of claims 1 to 12, further comprising 0.00001 to 0.01 mass% of a cooling agent (D).

14. The oral composition according to claim 13, wherein the cooling agent (D) is one or more selected from the group consisting of N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate, and menthyl succinate.

15. The oral composition according to any one of claims 1 to 14, which is a toothpaste or a gel toothpaste.

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