Skin protection composition comprising an antimicrobial agent and a (bio)-alkanediol

Abstract

The present invention relates to cosmetic or pharmaceutical compositions, preferably dermatological compositions, comprising or consisting of a specific antimicrobial component and an effective amount of 1,2-nonanediol and / or 2,3-nonanediol, or a specific alkanediol or a mixture of two or more different specific alkanediols, and the use of said compositions as personal care cosmetics, pharmaceuticals, or animal care. Furthermore, the present invention relates to the use of 1,2-nonanediol and / or 2,3-nonanediol, or a specific alkanediol or a mixture of two or more different specific alkanediols, for reducing or inhibiting antimicrobial activity on the skin or scalp, for balancing or reducing excess sebum production on the skin or scalp, for suppressing dandruff on the skin, scalp, or nails, and / or as an antimicrobial active ingredient replacer. Finally, the present invention relates to specific formulations, such as personal hygiene products, deodorants, antiperspirants, anti-acne products, or anti-dandruff products, comprising specific 1,2-alkanediols or 2,3-alkanediols or mixtures of specific 1,2-alkanediols and specific 2,3-alkanediols, as well as methods for reducing excess sebum production on the skin or scalp and / or for inhibiting dandruff on the skin, scalp, or nails.

Description

[Technical Field]

[0001] The present invention relates to cosmetic or pharmaceutical compositions, preferably dermatological compositions, comprising or consisting of a synergistic combination of a specific antimicrobial component and an effective amount of 1,2-nonanediol and / or 2,3-nonanediol, or a specific alkanediol or a mixture of two or more different specific alkanediols, and the use of said compositions as personal care cosmetics, pharmaceuticals, or animal care. Furthermore, the present invention relates to the use of 1,2-nonanediol and / or 2,3-nonanediol, or a specific alkanediol or a mixture of two or more different specific alkanediols, to reduce or inhibit antimicrobial activity on the skin or scalp, to balance or reduce excess sebum production on the skin or scalp, to suppress dandruff on the skin, scalp, or nails, and / or as an antimicrobial active ingredient replacer. Finally, the present invention relates to specific formulations, such as personal hygiene products, deodorants, antiperspirants, anti-acne products, or anti-dandruff products, comprising specific 1,2-alkanediols or 2,3-alkanediols or mixtures of specific 1,2-alkanediols and specific 2,3-alkanediols, as well as methods for reducing excess sebum production on the skin or scalp and / or for inhibiting dandruff on the skin, scalp, or nails. [Background technology]

[0002] Skin is the largest organ of the human body.Skin is colonized by a variety of microorganisms, most of which are harmless or even beneficial to their hosts.Colonization is driven by the ecology of the skin surface, but the skin surface is highly variable depending on local location, host intrinsic factors and environmental extrinsic factors.For example, the armpit is in a rather humid and nutrient-rich habitat, which provides favorable conditions for the growth of many microorganisms.Other habitats include sebum-rich habitats, such as the face, and rather dry and nutrient-poor habitats, such as most other body areas.

[0003] Many common skin pathogens, such as Staphylococcus aureus and Streptococcus pyogenes, are inhibited by an acidic pH, which favors the growth of coagulase-negative Staphylococci and Corynebacteria. However, occlusion of the skin results in an increase in pH, which favors the growth of Staphylococcus aureus and Streptococcus pyogenes.

[0004] Areas with a high density of sebaceous glands, such as the face, chest and back, promote the growth of lipophilic microorganisms such as Corynebacterium spp., Propionibacterium spp. and Malassezia spp.

[0005] Sebaceous glands are microscopic exocrine glands found throughout all areas of the skin. They secrete a natural oil called sebum, which, together with sweat, constitutes the sebaceous film that covers the skin. Human sebum is a complex mixture of triglycerides, fatty acids, wax esters, sterol esters, cholesterol, cholesterol esters, and squalene. Sebum is involved in epidermal development and barrier maintenance, antioxidant transport, contributing to mechanical protection, body odor, and pheromone production. Sebum is directly involved in hormone signaling, epidermal differentiation, and protection from ultraviolet (UV) radiation. Sebum works together to reduce skin water loss and modulate the composition and growth of the skin's natural microbiota.

[0006] There are two types of sebaceous glands: those connected to hair follicles in pilosebaceous units and those that exist independently. When these glands are associated with hair follicles, one or more glands may surround each follicle, and the glands themselves are surrounded by arrector pili muscles. Sebaceous glands are also found in hairless areas (glabrous skin), such as the eyelids (called meibomian glands), nose, labia minora, and the inner mucosa of the cheeks (Fordyce spots).

[0007] Unwanted overactivity of sebaceous glands (seborrhea) can also occur on other parts of the body, particularly the face. In the face, excessive sebum production can give the skin a shiny, aesthetically undesirable appearance (oily skin) and promote the formation of other tiny blemishes, such as comedones. In some cases, even more serious disorders can occur in the presence of excess sebum, such as acne, a skin disease characterized by an inflammatory process in hair follicles and associated sebaceous glands. Propionibacterium acnes (P. acnes, recently reclassified / renamed Cutibacterium acnes) is considered the infectious agent in acne.

[0008] Excessive production of sebum by the sebaceous glands of the scalp causes greasy hair and is considered a significant aesthetic problem. Seborrhea is responsible for the development of dandruff, a scalp disorder characterized by patchy, copious, loosely adherent scales that are usually accompanied by itching. This increased scalp scaling can evolve into seborrheic dermatitis, a severe form of dandruff accompanied by inflammation and erythema. The causes of dandruff and seborrheic dermatitis appear to depend on three factors: sebaceous gland secretions, metabolism of the microflora, and individual susceptibility supplemented by environmental conditions and personal lifestyle.

[0009] P. acnes is an aerotolerant anaerobe that lives deep within follicles and pores, using sebum, cellular debris, and metabolic by-products from surrounding skin tissue as their primary source of energy and nutrients. Increased sebum production due to overactive sebaceous glands or blocked follicles can favor P. acnes proliferation, causing the pustules (pimples) characteristic of acne inflammation.

[0010] In the case of acne, which usually occurs during puberty, the anaerobic microorganism P. acnes is crucially involved in the development of the condition, breaking down sebum into glycerin and fatty acids, which in turn stimulates the sebaceous glands to produce more sebum, and these breakdown products attack or destroy the walls of the follicles. Acne periodically causes inflammation of the skin (pimples, pustules, nodules, cysts), which, even after healing, are often accompanied by scarring, resulting in permanent damage to the appearance of those afflicted with unclean skin.

[0011] Finally, the female external genitalia contain numerous sebaceous glands, and these sebaceous secretions interact with bacterial microflora, regulating the pH of the genital area. Fresh sebum does not contain significant amounts of free fatty acids, but these are released as a result of the action of bacterial lipases, which induce acidification of the genital environment. Therefore, regulating sebum can be an important condition for preventing alterations in the genital microflora, irritation, itching, etc.

[0012] Other skin disorders and infections can be caused by bacteria and fungi: Chronic trauma, which affects diabetics, the elderly, and immobile individuals, is an example where commensal skin organisms can penetrate through gaps in the skin barrier and become pathogenic. While bacteria do not cause the initial traumatic event, they are thought to contribute to the lack of healing and persistent inflammation associated with chronic trauma. Burn wounds commonly become infected with S. pyogenes, Enterococcus spp., or Pseudomonas aeruginosa.

[0013] A more common skin commensal is Staphylococcus epidermidis, which is also the most frequent cause of hospital-acquired infections of indwelling medical devices, such as catheters or heart valves.

[0014] Therefore, there is a need for products that are able to control the skin microbial population, and in particular inhibit the growth of skin pathogens.

[0015] Therefore, further regulation of sebum production is a central issue for the prevention of dandruff and seborrheic dermatitis and therefore for controlling the colonization of the skin by certain microbial species that are lipid-dependent and feed on human serum.

[0016] As a result, the cosmetics industry is keenly interested in obtaining compounds or compositions suitable for inhibiting sebum production, especially when this activity is combined with anti-inflammatory properties.

[0017] WO 2008 / 046791 discloses the use of 1,2-decanediol to reduce sebum production on the skin and cosmetic or dermatological preparations for topical application containing 1,2-decanediol. In addition to 1,2-decanediol, the preparations optionally contain cleansing substances and antimicrobial agents.

[0018] On the other hand, 1,2-decanediol is an established antimicrobial agent used as a deodorant, antiperspirant, antidandruff, antiacne and other hygiene applications for oral or personal care.

[0019] However, the preparation, and in particular 1,2-decanediol, has the drawback of having a characteristic unpleasant odor.

[0020] When searching for agents with antimicrobial or sebum-reducing action, it must be taken into account that substances to be used in the cosmetics or pharmaceutical sector must be toxicologically acceptable, well tolerated by the skin, stable in particular in customary cosmetic and / or pharmaceutical formulations, substantially and preferably odorless, and cheap to prepare, i.e., using standard methods and / or starting from standard precursors.

[0021] However, there is no clear dependency between the chemical structure of a substance, on the one hand, and its biological activity against specific microorganisms or sebum production, on the other hand, which makes the search for suitable substances even more difficult. Furthermore, there is no predictable relationship between the antimicrobial activity, toxicological acceptability, tolerance, and stability of a substance.

[0022] Thus, there continues to be a further need to provide additional substances or combinations that have an inhibitory effect on the growth of microorganisms on mammalian skin or mucous membranes and / or that have an inhibitory effect on sebum production in the sebaceous glands of the skin or scalp.

[0023] It is therefore an object of the present invention to provide cosmetic or pharmaceutical compositions, in particular dermatological compositions, which have antimicrobial properties similar to or even better than those of cosmetic or pharmaceutical compositions according to the prior art.

[0024] It is a further object of the present invention to provide a cosmetic or pharmaceutical composition that simultaneously reduces or minimizes excess sebum production on the skin or scalp and / or reduces dandruff on the skin, scalp or nails.

[0025] It is a further object of the present invention to provide a cosmetic or pharmaceutical composition that is free of unpleasant odors.

[0026] Another object of the present invention is to provide a substance that enhances the action of an antimicrobial component in a cosmetic or pharmaceutical composition, such that the total content of antimicrobial components in the ready-to-use formulation can be reduced by achieving higher performance of the antimicrobial component at the same amount, or vice versa, by achieving the same performance with a lower amount of the antimicrobial component, and / or that reduces, minimizes, or inhibits excess sebum production on the skin or scalp and / or reduces dandruff on the skin, scalp, or nails upon application of the cosmetic or pharmaceutical composition.

[0027] It is a further object of the present invention to provide substances that can reduce the amount of antimicrobial components applied in cosmetic or pharmaceutical compositions, i.e., substances that are suitable as antimicrobial replacers.

[0028] A further object of the present invention is to provide a substance that does not have an unpleasant characteristic odor.

[0029] It has surprisingly been found that adding an effective amount of 1,2-nonanediol or 2,3-nonanediol or a mixture comprising 1,2-nonanediol and 2,3-nonanediol, or a specific alkanediol or a mixture of two or more different specific alkanediols, as defined herein, to a topical composition comprising an antimicrobial component significantly enhances the antimicrobial action of the antimicrobial component, i.e., results in a synergistic increase in the antimicrobial activity of the antimicrobial component against multiple microorganisms from the mammal's natural microbial population on the skin or scalp or mucous membranes.

[0030] In parallel, it has been found that the use in a topical composition of an effective amount of 1,2-nonanediol or 2,3-nonanediol or a mixture comprising 1,2-nonanediol and 2,3-nonanediol, or a specific alkanediol or a mixture of two or more different specific alkanediols, as defined herein, advantageously has a reducing effect, i.e., on sebum excess production and / or on dandruff.

[0031] Surprisingly, it has further been found that the total amount of antimicrobial components in a topical composition can be significantly reduced by the addition of an effective amount of 1,2-nonanediol or 2,3-nonanediol, or a mixture comprising 1,2-nonanediol and 2,3-nonanediol, or a specific alkanediol or a mixture of two or more of different specific alkanediols, as defined herein. Summary of the Invention

[0032] In order to achieve the above object, the present invention provides, in a first aspect, a cosmetic or pharmaceutical composition comprising or consisting of: (a1) 1,2-nonanediol, (b1) at least one antimicrobial component, and (c1) optionally at least one cosmetic or pharmaceutical active substance and / or additive; or (a2) 2,3-nonanediol, (b2) at least one antimicrobial component, and (c2) optionally at least one cosmetic or pharmaceutical active substance and / or additive; or (a3) a mixture containing 1,2-nonanediol and 2,3-nonanediol; (b3) at least one antimicrobial component, and (c3) optionally at least one cosmetic or pharmaceutical active substance and / or additive.

[0033] In a second aspect, the present invention provides a cosmetic or pharmaceutical composition comprising or consisting of: (a) at least one linear alkanediol having a carbon chain of 5 to 14 carbon atoms or a mixture comprising at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms and one or more second linear alkanediols different from the first linear alkanediol having a carbon chain of 5 to 14 carbon atoms; (b) at least one antimicrobial component, and (c) optionally at least one cosmetic or pharmaceutical active substance and / or additive.

[0034] In a further aspect, the present invention provides the cosmetic or non-therapeutic use of a composition according to the invention for personal care, in skin protection, skin care, scalp protection, scalp care, hair care, nail care or in the prevention and / or treatment of skin conditions, intolerant or sensitive skin, skin irritation, skin redness, pruritus (itching), loss of skin volume, loss of skin elasticity, dry skin, peeling, stickiness; or for animal care.

[0035] In a still further aspect, the present invention provides the use of a composition according to the invention as a medicament.

[0036] In a still further aspect, the present invention relates to the use of 1,2-nonanediol or 2,3-nonanediol or a mixture comprising 1,2-nonanediol and 2,3-nonanediol or a mixture comprising at least one linear alkanediol or at least one first linear alkanediol and one or more second linear alkanediols, as defined herein as a cosmetic or pharmaceutical product, in a cosmetic or pharmaceutical composition, to inhibit microbial activity, particularly on the skin or scalp, in particular Staphylococcus, Corynebacterium, Anaerococcus, Finegoldia, Moraxella, Porphyromonas, Fusobacterium, Aspergillus, and / or for balancing sebum production or reducing excess sebum production on the skin or scalp, and / or for inhibiting dandruff on the skin, scalp or nails, and / or as a replacer of an antimicrobial component.

[0037] Finally, the present invention provides a personal hygiene product, a deodorant, an antiperspirant, an anti-acne product, or an anti-dandruff product comprising a linear 1,2-alkanediol selected from the group consisting of 1,2-heptanediol, 1,2-nonanediol, 1,2-undecanediol, and 1,2-tridecanediol, or a linear 2,3-alkanediol selected from the group consisting of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, and 2,3-tridecanediol, or a mixture of a linear 1,2-alkanediol and a linear 2,3-alkanediol selected from the group consisting of: a mixture comprising 1,2-pentanediol and 2,3-pentanediol; a mixture comprising 1,2-hexanediol and 2,3-hexanediol; a mixture comprising 1,2-heptanediol and 2,3-heptanediol; a mixture comprising 1,2-octanediol and 2,3-octanediol; a mixture comprising 1,2-nonanediol and 2,3-nonanediol; a mixture comprising 1,2-undecanediol and 2,3-undecanediol, and A mixture comprising 1,2-tridecanediol and 2,3-tridecanediol. [Brief explanation of the drawings]

[0038] [Figure 1] FIG. 1 shows the characteristic odors of different 1,2-alkanediols.

[0039] [Figure 2] FIG. 1 shows the inhibitory influence of different 1,2-alkanediols and 2,3-alkanediols on sebum production in the sebaceous glands.

[0040] [Figure 3]FIG. 1 shows the inhibitory influence of 1,2-nonanediol at different concentrations on sebum production in the sebaceous glands. DETAILED DESCRIPTION OF THE INVENTION

[0041] The invention is set forth in the appended claims, but the invention itself, as well as preferred modifications thereof, other objects and advantages thereof, will also be apparent from the following detailed description taken in conjunction with the accompanying examples and drawings.

[0042] In a first aspect, the present invention relates to a cosmetic or pharmaceutical composition comprising or consisting of: (a1) 1,2-nonanediol, (b1) at least one antimicrobial component, and (c1) optionally at least one cosmetic or pharmaceutical active substance and / or additive.

[0043] Instead, the present invention relates in a first aspect to a cosmetic or pharmaceutical composition comprising or consisting of: (a2) 2,3-nonanediol, (b2) at least one antimicrobial component, and (c2) optionally at least one cosmetic or pharmaceutical active substance and / or additive.

[0044] In a further alternative aspect, the present invention relates to a cosmetic or pharmaceutical composition in the first aspect, comprising or consisting of: (a3) a mixture containing 1,2-nonanediol and 2,3-nonanediol; (b3) at least one antimicrobial component, and (c3) optionally at least one cosmetic or pharmaceutical active substance and / or additive.

[0045] In a second aspect, the present invention relates to a cosmetic or pharmaceutical composition comprising or consisting of: (a) at least one linear alkanediol having a carbon chain of 5 to 14 carbon atoms or a mixture comprising at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms and one or more second linear alkanediols different from the first linear alkanediol having a carbon chain of 5 to 14 carbon atoms; (b) at least one antimicrobial component, and (c) optionally at least one cosmetic or pharmaceutical active substance and / or additive.

[0046] In a more preferred variant of the second aspect, the present invention relates to a cosmetic or pharmaceutical composition comprising or consisting of: (a') a mixture comprising at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms and one or more second linear alkanediols having a carbon chain of 5 to 14 carbon atoms, wherein the first alkanediol and the second alkanediol have the same or different numbers of carbon atoms; (b') at least one antimicrobial component, and (c') optionally at least one cosmetic or pharmaceutical active substance and / or additive.

[0047] In a preferred variant of the second aspect of the invention, component (b) is different from component (a), or component (b') is different from component (a').

[0048] The term "comprising" means that the named component is essential, but that other components may be added and still be encompassed by the present invention.

[0049] The term "consisting of," when used in accordance with the present invention, means that the total amounts of components (a) through (c) add up to 100% by weight, based on the total weight of the cosmetic or pharmaceutical composition, and that the subject matter is closed-ended and may include only those limits expressly recited.

[0050] Whenever "comprises" is mentioned, it is intended to cover both meanings as alternatives, i.e., it can mean either "comprises" or "consists of," unless the context dictates otherwise.

[0051] The term "at least one of..." means that the cosmetic or pharmaceutical composition according to the present invention can contain any one of the respective components that follow the term, or a mixture of 2, 3, 4, 5, 6 or even more different components.

[0052] The term "optionally" means that the subsequently described compound may, but need not, be present in the composition, and the specification includes variations in which the compound is included or in which the compound is not present.

[0053] An alkanediol is any of a class of organic compounds that belong to the glycol, or alcohol, family. In a glycol molecule, the two hydroxyl (-OH) groups are attached to different carbon atoms in a carbon chain.

[0054] Component (a) in the cosmetic or pharmaceutical composition according to the first aspect of the present invention is either 1,2-nonanediol (a1) or 2,3-nonanediol (a2), or a mixture comprising both nonanediols, i.e., 1,2-nonanediol plus 2,3-nonanediol (a3).

[0055] 1,2-nonanediol belongs to the category of alkanediols and has the general formula: [ka] 1,2-nonanediol has a carbon chain of nine carbon atoms, and the two functional OH groups of the alkanediol are in the alpha and beta positions and are chemically bonded to the C1 and C2 carbon atoms in the alkanediol chain, and the two OH groups of the alkanediol are chemically bonded to the C1 and C2 carbon atoms in the alkanediol chain.

[0056] 2,3-nonanediol belongs to the category of alkanediols and has the general formula: [ka] 2,3-nonanediol is a straight-chain alkanediol with a carbon chain of nine carbon atoms, and the two functional OH groups of the alkanediol are in the beta and gamma positions, chemically bonded to the C2 and C3 carbon atoms of the alkanediol chain.

[0057] Linear 1,2-alkanediols have been used as multifunctional active ingredients for over 15 years. Short-chain 1,2-alkanediols are amphiphilic compounds and, therefore, like 1,2-pentanediol and 1,2-hexanediol, are soluble in both water and cosmetic oils. In contrast, 1,2-octanediol is a solid and tends to precipitate or recrystallize in oily solutions. 1,2-decanediol, on the other hand, is a solid and dissolves only in cosmetic oils. Apart from moisturizing, some 1,2-alkanediols are also used as viscosity modifiers.

[0058] Component (a) in the cosmetic or pharmaceutical composition according to the second aspect of the present invention is, in a first alternative embodiment, at least one linear alkanediol having a carbon chain of 5 to 14 carbon atoms.

[0059] Further, in a second alternative of this second aspect, component (a) can comprise a first linear alkanediol in combination with a second linear alkanediol, preferably a combination of at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms and at least one second linear alkanediol having a carbon chain of 5 to 14 carbon atoms. Thus, the present invention also calls for mixtures of the first and second alkanediols described herein.

[0060] The first linear alkanediol of the present invention can be selected from the same list and type of compounds as the linear alkanediol according to the first alternative embodiment of the second aspect, so that in the following reference is made to a general linear alkanediol, which can also be the first linear alkanediol. In a mixture of a first linear alkanediol and a second linear alkanediol, if they are specifically different, the specific terms "first" and "second" are used to distinguish between the two alkanediol components.

[0061] As used in this document, the phrase "at least one linear alkanediol" or "at least one first linear alkanediol" means a composition that can include one linear alkanediol having a carbon chain of 5 to 14 carbon atoms, or can include one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, or can include more than one linear alkanediol, or can include more than one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, i.e., two, three, four or more different linear alkanediols or first linear alkanediols having a carbon chain of 5 to 14 carbon atoms.

[0062] The linear alkanediol or first linear alkanediol consists of a chain of 5 to 14 carbon atoms linked together by a single covalent bond, with two OH functional groups attached to two different carbon atoms in the chain.

[0063] In the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the at least one linear alkanediol or at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol, tridecanediol and tetradecanediol.

[0064] In a preferred variant, the at least one linear alkanediol or the at least one first linear alkanediol is selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol and tridecanediol.

[0065] In a more preferred variant, the at least one linear alkanediol or the at least one first linear alkanediol is selected from the group consisting of alkanediols having an odd number of carbon atoms between 5 and 13, i.e., pentanediol, heptanediol, nonanediol, undecanediol, tridecanediol, and mixtures thereof.

[0066] In an even more preferred variant, the at least one linear alkanediol or the at least one first linear alkanediol is selected from the group consisting of alkanediols having an odd number of carbon atoms of 7, 9, 11 and 13, i.e., heptanediol, nonanediol, undecanediol and tridecanediol, or selected from the group consisting of alkanediols having an odd number of carbon atoms of 9 and 11, i.e., nonanediol and undecanediol, or selected from the group consisting of alkanediols having an odd number of carbon atoms of 9 and 13, i.e., nonanediol and tridecanediol, or selected from the group consisting of alkanediols having an odd number of carbon atoms of 11 and 13, i.e., undecanediol and tridecanediol.

[0067] In an even more preferred variation, the at least one linear alkanediol or the at least one first linear alkanediol is selected from the group consisting of nonanediol, undecanediol, tridecanediol.

[0068] In a particularly preferred variant, the at least one linear alkanediol or the at least one first linear alkanediol is either nonanediol or undecanediol.

[0069] In a most preferred variation, the at least one linear alkanediol or at least the first linear alkanediol is nonanediol.

[0070] In an alternative embodiment, the cosmetic or pharmaceutical composition according to the second aspect of the present invention comprises a mixture comprising at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms and one or more second linear alkanediols different from the first linear alkanediol and having a carbon chain of 5 to 14 carbon atoms.

[0071] This means that the alkanediol mixture is a mixture comprising at least one first linear alkanediol and one or more, i.e., two, three, four or more, second linear alkanediols having carbon chains of 5 to 14 carbon atoms. In this alternative embodiment, the first linear alkanediol can be any of the alkanediols described herein for linear alkanediols in general, and in particular for the first alternative embodiment of the second embodiment.

[0072] For example, a mixture can include one first linear alkanediol and one, two, three or more second linear alkanediols, or a mixture can include two first linear alkanediols with one, two, three or more second linear alkanediols, etc., provided that in each mixture the first and second linear alkanediols are different from one another.

[0073] The phrase "different from each other" means that the first linear alkanediol and the second linear alkanediol in the mixture either differ with respect to the length of their carbon chains, i.e., the number of carbon atoms, and / or differ with respect to their structural isomerism or with respect to their stereoisomerism.

[0074] Similarly, the first and second linear alkanediols in the mixture can have the same number of carbon atoms, for example, they have carbon chains of 7 carbon atoms, but the first and second linear alkanediols differ in terms of their structural isomerism or their stereoisomerism.

[0075] The second linear alkanediol preferably consists of a chain of 5 to 14 carbon atoms linked together by a single covalent bond, with two OH functional groups attached to two different carbon atoms in the chain.

[0076] In the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the at least one second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol, tridecanediol and tetradecanediol.

[0077] In a preferred variant, the at least one second linear alkanediol is selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol and tridecanediol.

[0078] When both the first alkanediol and the second alkanediol are, for example, heptanediol, the heptanediol of the second linear alkanediol is a different structural isomer or stereoisomer than the first linear alkanediol.

[0079] In a more preferred variation, the at least one second linear alkanediol is selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, nonanediol and decanediol, most preferably octanediol and nonanediol.

[0080] The term "alkanediol" also includes, within the context of the present invention, its structural or positional isomers. Structural isomers are compounds with the same molecular formula and different connectivity. Positional isomers, a specific form of structural isomerism, are structural isomers that can be considered to differ only in the position of functional groups on the parent structure, in this case the positions of the two alcohol functional groups.

[0081] Depending on the number of carbon atoms in the carbon chain of the alkanediol, various positional isomers of alkanediols exist: (x,x+1) structural isomers, (x,x+2) structural isomers, (x,x+3) structural isomers, etc. When the alcohol functional group is at the end of the carbon chain, it is an alpha-omega structural isomer (where x represents the number of carbon atoms in the alkanediol chain to which the OH groups of the alkanediol are chemically bonded). For example, when x is 1, the two OH groups of the alkanediol are chemically bonded to the C1 and C2 carbon atoms in the alkanediol chain. When x is 2, the two OH groups of the alkanediol are chemically bonded to the C2 and C3 carbon atoms in the alkanediol chain, etc.

[0082] In the (x,x+1) structural isomer, the two OH functional groups are attached adjacently to two different adjacent carbon atoms in the chain. In the (x,x+2) structural isomer, the two OH functional groups are attached adjacently to two different carbon atoms in the chain, and these two carbon atoms are separated by one C atom. In the (x,x+3) structural isomer, the two OH functional groups are attached adjacently to two different carbon atoms in the chain, and these two carbon atoms are separated by two C atoms. In the alpha,omega structural isomer, the two functional groups are attached to the first and terminal C atoms.

[0083] In a preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the invention, the linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably a vicinal (x,x+1) diol selected from the group consisting of 1,2-diols, 2,3-diols, 3,4-diols, 4,5-diols, as well as (x,x+1) diols, and mixtures thereof, preferably an alpha, beta 1,2 structural isomer.

[0084] In a preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the invention, the first and / or second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is a vicinal (x,x+1) diol selected from the group consisting of 1,2-diols, 2,3-diols, 3,4-diols, 4,5-diols, as well as (x,x+1) diols and mixtures thereof, preferably an alpha,beta 1,2 structural isomer.

[0085] In a further preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably a non-adjacent (x,x+2) diol selected from the group consisting of 1,3-diols, 2,4-diols, 3,5-diols, also (x,x+2) diols, and mixtures thereof, preferably an alpha, gamma 1,3 structural isomer.

[0086] In a preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the first and / or second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is a non-adjacent (x,x+2) diol selected from the group consisting of 1,3-diols, 2,4-diols, 3,5-diols, 4,6-diols, as well as (x,x+2) diols and mixtures thereof, preferably an alpha, gamma 1,3-configuration isomer.

[0087] In a further preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably a non-adjacent (x,x+3) diol selected from the group consisting of 1,4 diols, 2,5 diols, and also (x,x+3) diols, and mixtures thereof, preferably an alpha,delta 1,4 structural isomer.

[0088] In a preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the invention, the first linear alkanediol and / or the second linear alkanediol, having a carbon chain of 5 to 14 carbon atoms, is a non-adjacent (x,x+3) diol, preferably an alpha, delta 1,4 structural isomer, selected from the group consisting of 1,4 diols, 2,5 diols, and also (x,x+3) diols, or mixtures thereof.

[0089] In a preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the linear alkanediol or the first and / or second linear alkanediol is preferably an alpha,omega alkanediol, more preferably 1,8-octanediol or 1,9-nonanediol.

[0090] According to the present invention, vicinal (x, x+1) diols, such as alpha, beta or beta, gamma or gamma, delta, etc., are most preferred.

[0091] In a preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the linear alkanediol, in particular the first linear alkanediol and / or the second linear alkanediol, is a 1,2-alkanediol, a 2,3-alkanediol, a 3,4-alkanediol, or a mixture thereof, more preferably a 2,3-alkanediol.

[0092] The 1,2-alkanediol of the linear alkanediol, in particular the first linear alkanediol having a carbon chain of 5 to 14 carbon atoms and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms, can preferably be a 1,2-alkanediol represented by the following formula: [ka] 1,2-Pentanediol [ka] 1,2-Hexanediol [ka] 1,2-heptanediol [ka] 1,2-octanediol [ka] 1,2-Nonanediol [ka] 1,2-Decanediol [ka] 1,2-Undecanediol [ka] 1,2-Dodecanediol [ka] 1,2-Tridecanediol [ka] 1,2-Tetradecanediol

[0093] The 2,3-alkanediol of the linear alkanediol of the present invention, in particular the first linear alkanediol having a carbon chain of 5 to 14 carbon atoms and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms, can preferably be a 2,3-alkanediol represented by the following formula: [ka] 2,3-Pentanediol [ka] 2,3-Hexanediol [ka] 2,3-heptanediol [ka] 2,3-octanediol [ka] 2,3-Nonanediol [ka] 2,3-Decanediol [ka] 2,3-Undecanediol [ka] 2,3-Dodecanediol [ka] 2,3-Tridecanediol [ka] 2,3-Tetradecanediol

[0094] The 3,4-alkanediol of the linear alkanediol, preferably the first linear alkanediol having a carbon chain of 5 to 14 carbon atoms and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms, can preferably be a 3,4-alkanediol represented by the following formula: [ka] 3,4-Hexanediol [ka] 3,4-heptanediol [ka] 3,4-octanediol [ka] 3,4-Nonanediol [ka] 3,4-Decanediol [ka] 3,4-Undecanediol [ka] 3,4-Dodecanediol [ka] 3,4-Tridecanediol [ka] 3,4-Tetradecanediol

[0095] In a preferred variant, the cosmetic or pharmaceutical composition according to the second aspect of the present invention comprises a mixture comprising at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms and one or more second linear alkanediols having a carbon chain of 5 to 14 carbon atoms, wherein the first and second alkanediols have the same or different number of carbon atoms.

[0096] When both the first alkanediol and the second alkanediol have the same number of carbon atoms, such a combination of alkanediols is also referred to herein as a "homoalkanediol mixture" or "homocombination." For example, the first linear alkanediol and the second linear alkanediol have carbon chains of 7 carbon atoms, but the first linear alkanediol and the second linear alkanediol differ in terms of their structural isomerism or their stereoisomerism.

[0097] When the first alkanediol and the second alkanediol have different numbers of carbon atoms, such a combination of alkanediols is also referred to herein as a "heteroalkanediol mixture" or "heterocombination." For example, the first linear alkanediol has a carbon chain of 7 carbon atoms, and the second linear alkanediol has a carbon chain of 8 carbon atoms. However, the first linear alkanediol and the second linear alkanediol can also differ in terms of their structural isomerism or their stereoisomerism.

[0098] In a preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the invention, the linear alkanediol or first linear alkanediol is selected from the group consisting of: 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, 1,2-octanediol, 2,3-octanediol, 3,4-octanediol, 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, 1,2-decanediol, 2,3-decanediol, 3,4-decanediol, 1,2-undecanediol, 2,3-undecanediol, 3,4-undecanediol, 1,2-dodecanediol, 2,3-dodecanediol, 3,4-dodecanediol, 1,2-tridecanediol, 2,3-tridecanediol, 3,4-tridecanediol, and mixtures thereof.

[0099] Among the aforementioned linear alkanediols or first linear alkanediols, the alpha-beta structural isomers are preferred: 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, 2,3-tridecanediol, or mixtures thereof. The alkanediols are liquids with a purity of 90 to 99%.

[0100] Of the aforementioned liquid alkanediols, 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, or mixtures of said liquid alkanediols are particularly preferred, as they can be more easily incorporated into semi-finished or final products.

[0101] In a more preferred variant, the at least one linear alkanediol or the at least one first linear alkanediol is selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms between 5 and 13, i.e., 1,2-pentanediol, 1,2-heptanediol, 1,2-nonanediol, 1,2-undecanediol, 1,2-tridecanediol, and mixtures thereof.

[0102] In a more preferred variant, the linear alkanediol or first linear alkanediol is selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 7, 9, 11 and 13, i.e. 1,2-heptanediol, 1,2-nonanediol, 1,2-undecanediol or 1,2-tridecanediol, or selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 9 and 11, i.e. 1,2-nonanediol and 1,2-undecanediol, or selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 9 and 13, i.e. 1,2-nonanediol and 1,2-tridecanediol, or selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 11 and 13, i.e. 1,2-undecanediol and 1,2-tridecanediol.

[0103] In a more preferred variant, the linear alkanediol or first linear alkanediol is selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 9, 11 and 13, i.e. 1,2-nonanediol, 1,2-undecanediol or 1,2-tridecanediol.

[0104] In a more preferred variant, the at least one linear alkanediol or the at least one first linear alkanediol is selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms between 5 and 13, i.e., 2,3-pentanediol, 2,3-heptanediol, 2,3-nonanediol, 2,3-undecanediol, 2,3-tridecanediol, and mixtures thereof.

[0105] In an even more preferred variant, the linear alkanediol or first linear alkanediol is selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms, i.e., 7, 9, 11 and 13, i.e., 2,3-heptanediol, 2,3-nonanediol, 2,3-undecanediol or 2,3-tridecanediol, or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms, i.e., 2,3-nonanediol and 2,3-undecanediol, or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms, i.e., 2,3-nonanediol and 2,3-tridecanediol, or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms, i.e., 2,3-undecanediol and 2,3-tridecanediol, or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms, i.e., 11 and 13, i.e., 2,3-undecanediol and 2,3-tridecanediol.

[0106] In an even more preferred variant, the linear alkanediol or first linear alkanediol is selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms, 9, 11 and 13, i.e., 2,3-nonanediol, 2,3-undecanediol or 2,3-tridecanediol.

[0107] In a further preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the invention, the linear alkanediol or first linear alkanediol is selected from the group consisting of: 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, 1,2-undecanediol, 2,3-undecanediol, 3,4-undecanediol, 1,2-tridecanediol, 2,3-tridecanediol, 3,4-tridecanediol, 1,2-octanediol, 2,3-octanediol, 3,4-octanediol, and mixtures thereof.

[0108] More preferably, in the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the linear alkanediol or first linear alkanediol is selected from the group consisting of 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, and mixtures thereof, but the linear alkanediol or first linear alkanediol may also preferably be selected from the group consisting of 1,2-octanediol, 2,3-octanediol, 3,4-octanediol, and mixtures thereof.

[0109] Even more preferably, in the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the linear alkanediol or first linear alkanediol is an alpha, beta, or beta, gamma diol, either as 1,2-nonanediol, 2,3-nonanediol, or a mixture thereof. However, the linear alkanediol or first linear alkanediol can also preferably be 1,2-octanediol, 2,3-octanediol, or a mixture thereof. Mixtures of 1,2-nonanediol and 2,3-octanediol or mixtures of 1,2-octanediol and 2,3-nonanediol are also possible.

[0110] Most preferably, the linear alkanediol or first linear alkanediol is 1,2-octanediol or 1,2-nonanediol.

[0111] Likewise, in a further preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the invention, the linear alkanediol or first linear alkanediol is selected from the group consisting of: 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, 1,2-undecanediol, 2,3-undecanediol, 3,4-undecanediol, 1,2-tridecanediol, 2,3-tridecanediol, 3,4-tridecanediol, and mixtures thereof.

[0112] More preferably, in the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the linear alkanediol or first linear alkanediol is selected from the group consisting of 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, and mixtures thereof, or preferably from the group consisting of 1,2-undecanediol, 2,3-undecanediol, 3,4-undecanediol, and mixtures thereof, or preferably from the group consisting of 1,2-tridecanediol, 2,3-tridecanediol, 3,4-tridecanediol, and mixtures thereof.

[0113] Even more preferably, in the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the linear alkanediol or first linear alkanediol is alpha, beta or beta, gamma diol, either 1,2-nonanediol, 2,3-nonanediol, or mixtures thereof.

[0114] Furthermore, the linear alkanediol or first linear alkanediol may also preferably be 1,2-undecanediol, 2,3-undecanediol, or a mixture thereof. Mixtures of 1,2-nonanediol and / or 2,3-undecanediol, or mixtures of 2,3-nonanediol and / or 2,3-undecanediol, or mixtures of 1,2-undecanediol and / or 2,3-nonanediol are also possible.

[0115] In yet a more preferred variant, the at least one linear alkanediol or the at least one first linear alkanediol is selected from the group consisting of 1,2-nonanediol and 1,2-undecanediol, both 1,2-alkanediols being characterized by pronounced antimicrobial activity, having a pronounced sebum-reducing effect and being odorless compared to 1,2-decanediol, which has an unpleasant characteristic odor.

[0116] In a most preferred variation, the at least one linear alkanediol or the at least one first linear alkanediol is 1,2-nonanediol.

[0117] Preferably, the at least one linear alkanediol is selected from the group consisting of 2,3-alkanediols such as 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, and 2,3-tridecanediol. More preferably, the at least one linear alkanediol is selected from the group consisting of 2,3-heptanediol, 2,3-nonanediol, and 2,3-undecanediol.

[0118] 2,3-alkanediols have the advantage that they have antimicrobial efficacy, while on the other hand, they have enhanced sebum-reducing effect compared to their respective 1,2-alkanediols.Furthermore, 2,3-alkanediols have the advantage that they are liquid, and therefore can be more easily incorporated into semi-finished products or final products.Therefore, when combining alkanediols, a good compromise can be achieved in a way that maintains antimicrobial and sebum-reducing effect while improving the processability of the formulation.

[0119] In a preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the invention, the second linear alkanediol is selected from the group consisting of: 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, 1,2-octanediol, 2,3-octanediol, 3,4-octanediol, 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, 1,2-decanediol, 2,3-decanediol, 3,4-decanediol, 1,2-undecanediol, 2,3-undecanediol, 3,4-undecanediol, 1,2-dodecanediol, 2,3-dodecanediol, 3,4-dodecanediol, 1,2-tridecanediol, 2,3-tridecanediol, 3,4-tridecanediol, and mixtures thereof.

[0120] Among the aforementioned second linear alkanediols, alpha-beta structural isomers are particularly preferred: 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, 2,3-tridecanediol, or mixtures thereof. The alkanediols are liquids with a purity of 90 to 99%.

[0121] Among the aforementioned liquid alkanediols, 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, or mixtures of said liquid alkanediols are particularly preferred, as they can be more easily incorporated into semi-finished or final products.

[0122] In a more preferred variant, the second linear alkanediol is selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms between 5 and 13, i.e., 1,2-pentanediol, 1,2-heptanediol, 1,2-nonanediol, 1,2-undecanediol, 1,2-tridecanediol, and mixtures thereof.

[0123] In a more preferred variant, the second linear alkanediol is selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 7, 9, 11 and 13, i.e., 1,2-heptanediol, 1,2-nonanediol, 1,2-undecanediol and 1,2-tridecanediol, or selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 9 and 11, i.e., 1,2-nonanediol and 1,2-undecanediol, or selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 9 and 13, i.e., 1,2-nonanediol and 1,2-tridecanediol, or selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 11 and 13, i.e., 1,2-undecanediol and 1,2-tridecanediol.

[0124] In a more preferred variant, the second linear alkanediol is selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms, 9, 11 and 13, i.e., 1,2-nonanediol, 1,2-undecanediol or 1,2-tridecanediol.

[0125] In a more preferred variant, the second linear alkanediol is selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms between 5 and 13, i.e., 2,3-pentanediol, 2,3-heptanediol, 2,3-nonanediol, 2,3-undecanediol, 2,3-tridecanediol, and mixtures thereof.

[0126] In even more preferred variations, the second linear alkanediol is selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms, i.e., 7, 9, 11 and 13, i.e., 2,3-heptanediol, 2,3-nonanediol, 2,3-undecanediol and 2,3-tridecanediol, or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms, i.e., 2,3-nonanediol and 2,3-undecanediol, or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms, i.e., 2,3-nonanediol and 2,3-tridecanediol, or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms, i.e., 2,3-undecanediol and 2,3-tridecanediol, or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms, i.e., 11 and 13, i.e., 2,3-undecanediol and 2,3-tridecanediol.

[0127] In an even more preferred variation, the second linear alkanediol is selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms, 9, 11 and 13, i.e., 2,3-nonanediol, 2,3-undecanediol or 2,3-tridecanediol.

[0128] In a more preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the invention, the second linear alkanediol is selected from the group consisting of: 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol, and mixtures thereof.

[0129] More preferably, in the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the second linear alkanediol is selected from the group consisting of 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, and mixtures thereof, but the second linear alkanediol may also preferably be selected from the group consisting of 1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol, and mixtures thereof.

[0130] Even more preferably, in the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the second linear alkanediol is an alpha, beta, or beta, gamma diol, either as 1,2-pentanediol, 2,3-pentanediol, or a mixture thereof. However, the second linear alkanediol can also preferably be 1,2-hexanediol or 2,3-hexanediol, or a mixture thereof. Mixtures of 1,2-pentanediol and 2,3-hexanediol or 2,3-pentanediol and 1,2-hexanediol are also possible.

[0131] Most preferably, the second linear alkanediol is 1,2-pentanediol or 2,3-pentanediol or 1,2-hexanediol or 2,3-hexanediol or 1,2-heptanediol or 2,3-heptanediol or 2,3-octanediol or 2,3-nonanediol or 2,3-undecanediol.

[0132] In a particularly preferred variant, the cosmetic or pharmaceutical composition according to the second aspect of the invention comprising a mixture or combination comprising at least one first linear alkanediol and one or more second linear alkanediols comprises any one of the following mixtures / combinations: mixtures containing 1,2-pentanediol and 2,3-pentanediol, mixtures containing 1,2-hexanediol and 2,3-hexanediol, mixtures containing 1,2-heptanediol and 2,3-heptanediol, mixtures containing 1,2-octanediol and 2,3-octanediol, mixtures containing 1,2-nonanediol and 2,3-nonanediol, mixtures comprising 1,2-decanediol and 2,3-decanediol, mixtures comprising 1,2-undecanediol and 2,3-undecanediol, a mixture containing 1,2-dodecanediol and 2,3-dodecanediol, or A mixture containing 1,2-tridecanediol and 2,3-tridecanediol.

[0133] In the homoalkanediol mixture, the first linear alkanediol and the second alkanediol have the same number of carbon atoms.

[0134] Particularly preferred are combinations comprising 1,2-nonanediol in combination with 2,3-nonanediol and / or 3,4-nonanediol, or 1,2-undecanediol in combination with 2,3-undecanediol and / or 3,4-undecanediol, or 1,2-octanediol in combination with 2,3-octanediol and / or 3,4-octanediol.

[0135] Due to their excellent antimicrobial and sebum-reducing effects, an alkanediol mixture containing 1,2-nonanediol and 2,3-nonanediol, or an alkanediol mixture containing 1,2-undecanediol and 2,3-undecanediol is most preferred.

[0136] The above-identified homoalkanediol mixtures according to the second aspect of the present invention, comprising a 1,2-alkanediol and a 2,3-alkanediol having the same number of carbon atoms, are characterized by synergistic antimicrobial efficacy, i.e., antimicrobial activity that inhibits microbial growth, when used in combination with antimicrobial components, compared to the respective single 1,2-alkanediol or 2,3-alkanediol substances, as demonstrated in the following examples. Furthermore, application of a mixture comprising a 1,2-alkanediol and a 2,3-alkanediol has a positive effect on sebum production in the sebaceous glands, i.e., an inhibitory effect, by suppressing sebum production, thereby reducing sebum production.

[0137] The synergistic antimicrobial and sebum reducing effects or activity were found for homomixtures including 1,2-pentanediol and 2,3-pentanediol in combination with antimicrobial components.

[0138] The synergistic antimicrobial and sebum-reducing effects are also observed for homomixtures containing 1,2-hexanediol and 2,3-hexanediol in combination with antimicrobial components.

[0139] Homomixtures containing 1,2-heptanediol and 2,3-heptanediol in combination with antimicrobial components are particularly beneficial as they have certain significant synergistic antimicrobial and sebum-reducing effects.

[0140] Particularly advantageous are alkanediol mixtures comprising 1,2-octanediol and 2,3-octanediol in combination with an antimicrobial component or 1,2-nonanediol and 2,3-nonanediol in combination with an antimicrobial component. Both mixtures provide low MIC values ​​against the microorganisms tested and are effective in reducing sebum production.

[0141] Additionally, an alkanediol mixture containing 1,2-decanediol and 2,3-decanediol or an alkanediol mixture containing 1,2-undecanediol and 2,3-undecanediol synergistically reduces the amount of microorganisms and also reduces sebum production when used in combination with a different antimicrobial agent.

[0142] Synergy also applies to alkanediol mixtures containing 1,2-dodecanediol and 2,3-dodecanediol, or 1,2-tridecanediol and 2,3-tridecanediol in combination with an antimicrobial component. Antimicrobial efficacy is observed at SI values ​​of less than 1. The mixtures can also be used to reduce sebum secretion.

[0143] The above-identified homoalkanediol mixtures, comprising a 1,2-alkanediol and the corresponding 2,3-alkanediol, act synergistically against microorganisms of the natural microbial population of mammalian skin when used in combination with an antimicrobial component.

[0144] The above-mentioned synergistically enhanced antimicrobial activity is particularly pronounced for homomixtures comprising 1,2-nonanediol and 2,3-nonanediol or 1,2-undecanediol and 2,3-undecanediol compared to the corresponding individual 1,2-alkanediol or 2,3-alkanediol substances, while simultaneously reducing sebum production.

[0145] The above-described antimicrobial efficacy and sebum reduction of mixtures containing 1,2-alkanediols and the corresponding 2,3-alkanediols can be used to reduce microorganisms on the skin, thereby resulting in a reduction in dandruff or acne.

[0146] Furthermore, by blending a solid 1,2-alkanediol with a corresponding liquid 2,3-alkanediol, solid 1,2-alkanediols, such as 1,2-octanediol and 1,2-nonanediol, can be dissolved to obtain a liquid alkanediol mixture. The 2,3-alkanediol acts as a solvent for the solid 1,2-alkanediol. Such a liquid mixture has the advantages of, first, improving the availability of the solid 1,2-alkanediol in the mixture and, second, facilitating its incorporation into semi-finished or final products. This effect is particularly advantageous for emulsions. When used alone in emulsions, lipophilic 1,2-alkanediols with carbon chains of 8 or more carbon atoms tend to migrate to the oil phase. By blending with the corresponding liquid 2,3-alkanediol, the 1,2-alkanediol remains in the aqueous phase, where microbial contamination typically occurs. This makes it particularly advantageous for the antimicrobial action of the 1,2-alkanediols to occur in the aqueous phase.

[0147] Solutions of solid 1,2-nonanediol in liquid 2,3-nonanediol or solid 1,2-undecanediol in liquid 2,3-undecanediol may be used to similarly improve the availability of strong antimicrobial 1,2-nonanediol or 1,2-undecanediol materials in end uses.

[0148] In addition, the above alkanediol mixtures comprising a 1,2-alkanediol and the corresponding 2,3-alkanediol make it possible to obtain cold preparations of cosmetic or pharmaceutical formulations, ie no heating is required during preparation.

[0149] Thus, the above-described properties of the identified alkanediol mixtures containing 1,2-alkanediols and respective 2,3-alkanediols can be used to improve the processability of formulations.

[0150] Thus, when combining active antimicrobial mixtures, a good compromise can be achieved in a manner that maintains antimicrobial and sebum-reducing activity while improving formulation processability. Combining the above-identified 1,2-alkanediols with the corresponding 2,3-alkanediols solves this balancing issue for 1,2-alkanediol substances or 2,3-alkanediol substances alone. This is achieved satisfactorily, for example, by combinations including 1,2-pentanediol and 2,3-pentanediol, as well as 1,2-hexanediol and 2,3-hexanediol. Also exhibiting this effect are combinations including 1,2-heptanediol and 2,3-heptanediol, as well as 1,2-octanediol and 2,3-octanediol. This is particularly true when 1,2-nonanediol is combined with 2,3-nonanediol, and when 1,2-undecanediol is combined with 2,3-undecanediol.

[0151] The above-identified homoalkanediol mixtures containing a 1,2-alkanediol and the corresponding 2,3-alkanediol in combination with an antimicrobial component exhibit significant synergistic activity and are clearly superior to the corresponding 1,2-alkanediol or 2,3-alkanediol individually and at the same concentration.

[0152] Thus, in a particularly preferred variant, the cosmetic or pharmaceutical composition according to the second aspect of the invention comprising a mixture or combination comprising at least one first linear alkanediol and one or more second linear alkanediols includes any one of the following mixtures / combinations: 1,2-pentanediol in combination with one of 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol; 1,2-hexanediol in combination with one of 1,2-pentanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol; 1,2-heptanediol in combination with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, 1,2-octanediol in combination with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, 1,2-nonanediol in combination with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, 1,2-decanediol in combination with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, 1,2-undecanediol in combination with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-dodecanediol, or 1,2-tridecanediol, 1,2-dodecanediol in combination with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, or 1,2-tridecanediol, combinations of 1,2-tridecanediol with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, or 1,2-dodecanediol; 2,3-pentanediol in combination with one of 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, 2,3-hexanediol in combination with one of 1,2-pentanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, 2,3-heptanediol in combination with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, 2,3-octanediol in combination with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, 2,3-nonanediol in combination with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, 2,3-decanediol in combination with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol; 2,3-undecanediol in combination with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-dodecanediol, or 1,2-tridecanediol, a combination of 2,3-dodecanediol with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, or 1,2-tridecanediol, or 2,3-tridecanediol in combination with one of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, or 1,2-dodecanediol, 2,3-pentanediol in combination with one of 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol or 2,3-tridecanediol, 2,3-hexanediol in combination with one of 2,3-pentanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol or 2,3-tridecanediol, 2,3-heptanediol in combination with one of 2,3-pentanediol, 2,3-hexanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol or 2,3-tridecanediol, 2,3-octanediol in combination with one of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol or 2,3-tridecanediol, 2,3-nonanediol in combination with one of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, combinations of 2,3-decanediol with one of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol; 2,3-undecanediol in combination with one of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-dodecanediol, or 2,3-tridecanediol, a combination of 2,3-dodecanediol with one of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, or 2,3-tridecanediol, or A combination of 2,3-tridecanediol with one of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, or 2,3-dodecanediol.

[0153] Thus, in certain preferred variants, the cosmetic or pharmaceutical composition according to the second aspect of the invention comprising a mixture or combination comprising at least one first linear alkanediol and one or more second linear alkanediols may comprise any of the following mixtures / combinations: 1,2-heptanediol and 1,2-pentanediol, or 1,2-heptanediol and 1,2-hexanediol, or 1,2-heptanediol and 1,2-octanediol, or 1,2-heptanediol and 1,2-nonanediol, or 1,2-heptanediol and 1,2-decanediol, or 1,2-heptanediol and 1,2-undecanediol, or 1,2-heptanediol and 1,2-dodecanediol, or 1,2-heptanediol and 1,2-tridecanediol, or 1,2-nonanediol and 1,2-pentanediol, or 1,2-nonanediol and 1,2-hexanediol, or 1,2-nonanediol and 1,2-octanediol, or 1,2-nonanediol and 1,2-decanediol, or 1,2-nonanediol and 1,2-undecanediol, or 1,2-nonanediol and 1,2-dodecanediol, or 1,2-nonanediol and 1,2-tridecanediol, or 1,2-undecanediol and 1,2-pentanediol, or 1,2-undecanediol and 1,2-hexanediol, or 1,2-undecanediol and 1,2-octanediol, or 1,2-undecanediol and 1,2-nonanediol, or 1,2-undecanediol and 1,2-decanediol, or 1,2-undecanediol and 1,2-dodecanediol, or · 1,2-Undecanediol and 1,2-Tridecanediol.

[0154] Thus, in certain preferred variants, the cosmetic or pharmaceutical composition according to the second aspect of the invention comprising a mixture or combination comprising at least one first linear alkanediol and one or more second linear alkanediols may comprise any of the following mixtures / combinations: 1,2-pentanediol and 2,3-pentanediol, 1,2-pentanediol and 2,3-hexanediol, 1,2-pentanediol and 2,3-heptanediol, 1,2-pentanediol and 2,3-octanediol, 1,2-pentanediol and 2,3-nonanediol, 1,2-pentanediol and 2,3-decanediol, 1,2-pentanediol and 2,3-undecanediol, 1,2-pentanediol and 2,3-dodecanediol, 1,2-pentanediol and 2,3-tridecanediol, 1,2-hexanediol and 2,3-pentanediol, 1,2-hexanediol and 2,3-hexanediol, 1,2-hexanediol and 2,3-heptanediol, 1,2-hexanediol and 2,3-octanediol, 1,2-hexanediol and 2,3-nonanediol, 1,2-hexanediol and 2,3-decanediol, 1,2-hexanediol and 2,3-undecanediol, 1,2-hexanediol and 2,3-dodecanediol, 1,2-hexanediol and 2,3-tridecanediol, 1,2-heptanediol and 2,3-pentanediol, 1,2-heptanediol and 2,3-hexanediol, 1,2-heptanediol and 2,3-heptanediol, 1,2-heptanediol and 2,3-octanediol, 1,2-heptanediol and 2,3-nonanediol, 1,2-heptanediol and 2,3-decanediol, 1,2-heptanediol and 2,3-undecanediol, 1,2-heptanediol and 2,3-dodecanediol, 1,2-heptanediol and 2,3-tridecanediol, 1,2-octanediol and 2,3-pentanediol, 1,2-octanediol and 2,3-hexanediol, 1,2-octanediol and 2,3-heptanediol, 1,2-octanediol and 2,3-octanediol, 1,2-octanediol and 2,3-nonanediol, 1,2-octanediol and 2,3-decanediol, 1,2-octanediol and 2,3-undecanediol, 1,2-octanediol and 2,3-dodecanediol, 1,2-octanediol and 2,3-tridecanediol, 1,2-nonanediol and 2,3-pentanediol, 1,2-nonanediol and 2,3-hexanediol, 1,2-nonanediol and 2,3-heptanediol, 1,2-nonanediol and 2,3-octanediol, 1,2-nonanediol and 2,3-nonanediol, 1,2-nonanediol and 2,3-decanediol, 1,2-nonanediol and 2,3-undecanediol, 1,2-nonanediol and 2,3-dodecanediol, 1,2-nonanediol and 2,3-tridecanediol, 1,2-decanediol and 2,3-pentanediol, 1,2-decanediol and 2,3-hexanediol, 1,2-decanediol and 2,3-heptanediol, 1,2-decanediol and 2,3-octanediol, 1,2-decanediol and 2,3-nonanediol, 1,2-decanediol and 2,3-decanediol, 1,2-decanediol and 2,3-undecanediol, 1,2-decanediol and 2,3-dodecanediol, 1,2-decanediol and 2,3-tridecanediol, 1,2-undecanediol and 2,3-pentanediol, 1,2-undecanediol and 2,3-hexanediol, 1,2-undecanediol and 2,3-heptanediol, 1,2-undecanediol and 2,3-octanediol, 1,2-undecanediol and 2,3-nonanediol, 1,2-undecanediol and 2,3-decanediol, 1,2-undecanediol and 2,3-undecanediol, 1,2-undecanediol and 2,3-dodecanediol, 1,2-undecanediol and 2,3-tridecanediol, or 1,2-dodecanediol and 2,3-pentanediol, 1,2-dodecanediol and 2,3-hexanediol, 1,2-dodecanediol and 2,3-heptanediol, 1,2-dodecanediol and 2,3-octanediol, 1,2-dodecanediol and 2,3-nonanediol, 1,2-dodecanediol and 2,3-decanediol, 1,2-dodecanediol and 2,3-undecanediol, 1,2-dodecanediol and 2,3-dodecanediol, · 1,2-dodecanediol and 2,3-tridecanediol.

[0155] Thus, in certain preferred variants, the cosmetic or pharmaceutical composition according to the second aspect of the invention, comprising a mixture or combination comprising at least one first linear alkanediol and one or more second linear alkanediols, may comprise any of the following combinations: 1,2-heptanediol and 2,3-heptanediol, or 1,2-heptanediol and 2,3-pentanediol, or 1,2-heptanediol and 2,3-hexanediol, or 1,2-heptanediol and 2,3-nonanediol, or 1,2-heptanediol and 2,3-decanediol, or 1,2-heptanediol and 2,3-undecanediol, or 1,2-heptanediol and 2,3-dodecanediol, or 1,2-heptanediol and 2,3-tridecanediol, or 1,2-nonanediol and 2,3-pentanediol, or 1,2-nonanediol and 2,3-hexanediol, or 1,2-nonanediol and 2,3-octanediol, or 1,2-nonanediol and 2,3-decanediol, or 1,2-nonanediol and 2,3-undecanediol, or 1,2-nonanediol and 2,3-dodecanediol, or 1,2-nonanediol and 2,3-tridecanediol, or 1,2-undecanediol and 2,3-pentanediol, or 1,2-undecanediol and 2,3-hexanediol, or 1,2-undecanediol and 2,3-octanediol, or 1,2-undecanediol and 2,3-nonanediol, or 1,2-undecanediol and 2,3-decanediol, or 1,2-undecanediol and 2,3-dodecanediol, or · 1,2-undecanediol and 2,3-tridecanediol.

[0156] Thus, in certain preferred variants, the cosmetic or pharmaceutical composition according to the second aspect of the invention comprising a mixture or combination comprising at least one first linear alkanediol and one or more second linear alkanediols may comprise any of the following mixtures / combinations: 2,3-pentanediol and 2,3-hexanediol, 2,3-pentanediol and 2,3-heptanediol, 2,3-pentanediol and 2,3-octanediol, 2,3-pentanediol and 2,3-nonanediol, 2,3-pentanediol and 2,3-decanediol, 2,3-pentanediol and 2,3-undecanediol, 2,3-pentanediol and 2,3-dodecanediol, 2,3-pentanediol and 2,3-tridecanediol, 2,3-hexanediol and 2,3-pentanediol, 2,3-hexanediol and 2,3-heptanediol, 2,3-hexanediol and 2,3-octanediol, 2,3-hexanediol and 2,3-nonanediol, 2,3-hexanediol and 2,3-decanediol, 2,3-hexanediol and 2,3-undecanediol, 2,3-hexanediol and 2,3-dodecanediol, 2,3-hexanediol and 2,3-tridecanediol, 2,3-heptanediol and 2,3-pentanediol, 2,3-heptanediol and 2,3-hexanediol, 2,3-heptanediol and 2,3-octanediol, 2,3-heptanediol and 2,3-nonanediol, 2,3-heptanediol and 2,3-decanediol, 2,3-heptanediol and 2,3-undecanediol, 2,3-heptanediol and 2,3-dodecanediol, 2,3-heptanediol and 2,3-tridecanediol, 2,3-octanediol and 2,3-pentanediol, 2,3-octanediol and 2,3-hexanediol, 2,3-octanediol and 2,3-heptanediol, 2,3-octanediol and 2,3-nonanediol, 2,3-octanediol and 2,3-decanediol, 2,3-octanediol and 2,3-undecanediol, 2,3-octanediol and 2,3-dodecanediol, 2,3-octanediol and 2,3-tridecanediol, 2,3-nonanediol and 2,3-pentanediol, 2,3-nonanediol and 2,3-hexanediol, 2,3-nonanediol and 2,3-heptanediol, 2,3-nonanediol and 2,3-octanediol, 2,3-nonanediol and 2,3-decanediol, 2,3-nonanediol and 2,3-undecanediol, 2,3-nonanediol and 2,3-dodecanediol, 2,3-nonanediol and 2,3-tridecanediol, 2,3-decanediol and 2,3-pentanediol, 2,3-decanediol and 2,3-hexanediol, 2,3-decanediol and 2,3-heptanediol, 2,3-decanediol and 2,3-octanediol, 2,3-decanediol and 2,3-nonanediol, 2,3-decanediol and 2,3-undecanediol, 2,3-decanediol and 2,3-dodecanediol, 2,3-decanediol and 2,3-tridecanediol, 2,3-undecanediol and 2,3-pentanediol, 2,3-undecanediol and 2,3-hexanediol, 2,3-undecanediol and 2,3-heptanediol, 2,3-undecanediol and 2,3-octanediol, 2,3-undecanediol and 2,3-nonanediol, 2,3-undecanediol and 2,3-decanediol, 2,3-undecanediol and 2,3-dodecanediol, 2,3-undecanediol and 2,3-tridecanediol, or · 2,3-Dodecanediol and 2,3-Tridecanediol.

[0157] Particularly preferred are mixtures comprising 2,3-hexanediol and 2,3-heptanediol, or 2,3-hexanediol and 2,3-octanediol, or 2,3-heptanediol and 2,3-octanediol.

[0158] In the heteroalkanediol mixtures previously described, the first linear alkanediol and the second linear alkanediol have different numbers of carbon atoms.

[0159] The heteroalkanediol mixtures according to the second aspect of the present invention, as specified above, comprising at least one first linear alkanediol and one or more second linear alkanediols, when used in combination with an antimicrobial component, are characterized by a synergistic antimicrobial efficacy, i.e., an antimicrobial effect by inhibiting the growth of microorganisms, compared to each of these single alkanediol substances, as demonstrated in the following examples. Furthermore, application of the alkanediol mixtures has a positive effect on sebum production in the sebaceous glands, i.e., an inhibitory effect, by suppressing sebum production, thereby reducing sebum production.

[0160] Particularly preferred are the above-identified heteroalkanediol mixtures comprising 1,2-hexanediol and 2,3-octanediol, or 1,2-octanediol and 2,3-hexanediol, or 1,2-octanediol and 2,3-heptanediol, which exhibit synergistic antimicrobial and sebum-reducing effects compared to the corresponding single 1,2-alkanediol or 2,3-alkanediol substances, i.e., 1,2-hexanediol or 1,2-octanediol or 2,3-octanediol or 2,3-hexanediol or 2,3-heptanediol.

[0161] The synergistic antimicrobial and sebum reducing effects or activity have been found for heteromixtures containing 1,2-hexanediol and 2,3-octanediol when used in combination with antimicrobial agents.

[0162] The synergistic antimicrobial and sebum-reducing effects are also observed for heteromixtures containing 1,2-octanediol and 2,3-hexanediol in combination with antimicrobial agents.

[0163] Heteromixtures containing 1,2-octanediol and 2,3-heptanediol in combination with antimicrobial agents are particularly beneficial as they have a particularly pronounced synergistic antimicrobial and sebum-reducing effect.

[0164] Furthermore, significant antimicrobial activity and sebum reduction are also observed for the following specified alkanediol mixtures, when used in combination with an antimicrobial component: an alkanediol mixture comprising 1,2-pentanediol and 2,3-hexanediol; or a mixture comprising 1,2-pentanediol and 1,2-heptanediol; or a mixture comprising 1,2-pentanediol and 2,3-heptanediol; or a mixture comprising 1,2-pentanediol and 2,3-octanediol; or a mixture comprising 1,2-pentanediol and 1,2-nonanediol; or a mixture comprising 1,2-pentanediol and 2,3-nonanediol.

[0165] The above-identified heteroalkanediol mixtures comprising at least one first linear alkanediol and one or more second alkanediols exhibit synergistic activity when used in combination with antimicrobial components by inhibiting microbial growth and suppressing sebum production in the sebaceous glands.

[0166] Heteromixtures comprising 1,2-pentanediol and 2,3-hexanediol are particularly beneficial as they have certain significant synergistic antimicrobial and sebum-reducing effects when used in combination with antimicrobial components.

[0167] Alkanediol mixtures comprising 1,2-pentanediol and 1,2-heptanediol or 1,2-pentanediol and 2,3-heptanediol are particularly advantageous because these mixtures provide low MIC values ​​against the microorganisms tested and are effective in reducing sebum production.

[0168] Similarly, synergistic antimicrobial and sebum-reducing effects or activity have also been found for heteromixtures containing 1,2-pentanediol and 2,3-octanediol when used in combination with antimicrobial components.

[0169] Additionally, an alkanediol mixture containing 1,2-pentanediol and 1,2-nonanediol or an alkanediol mixture containing 1,2-pentanediol and 2,3-nonanediol, when used in combination with an antimicrobial agent, synergistically reduces the amount of microorganisms and also reduces sebum production.

[0170] Furthermore, significant antimicrobial activity and sebum reduction are also observed for the following identified alkanediol mixtures when used in combination with antimicrobial components: an alkanediol mixture comprising 1,2-heptanediol and 1,2-octanediol, or an alkanediol mixture comprising 1,2-heptanediol and 2,3-octanediol, or an alkanediol mixture comprising 1,2-heptanediol and 1,2-nonanediol, or a mixture or combination of alkanediols comprising 1,2-heptanediol and 2,3-nonanediol.

[0171] Alkanediol mixtures comprising 1,2-heptanediol and 1,2-octanediol or 1,2-heptanediol and 2,3-octanediol are particularly advantageous because, when used in combination with antimicrobial components, these mixtures provide low MIC values ​​against the microorganisms tested and are effective in reducing sebum production.

[0172] Additionally, an alkanediol mixture containing 1,2-heptanediol and 1,2-nonanediol, or an alkanediol mixture containing 1,2-heptanediol and 2,3-nonanediol, when used in combination with a different antimicrobial agent, synergistically reduces the amount of microorganisms and also reduces sebum production.

[0173] The use of the previously identified alkanediol mixtures in combination with antimicrobial components inhibits the growth of microorganisms, resulting in enhanced, i.e., synergistically enhanced, antimicrobial activity when used with the antimicrobial component compared to the use of the corresponding single alkanediol substance. Furthermore, application of these alkanediol mixtures has a positive, i.e., inhibitory, effect on sebum production in the sebaceous glands, thereby reducing sebum production.

[0174] The above-described antimicrobial efficacy and sebum reduction of a mixture comprising a first linear alkanediol and a second linear alkanediol can be used to reduce microorganisms on the skin, thereby resulting in, for example, a reduction in dandruff or acne.

[0175] In a preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the invention, the linear alkanediol is a 2,3-alkanediol, preferably selected from the group consisting of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, 2,3-tridecanediol, and mixtures thereof.

[0176] In a more preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the invention, the linear alkanediol is selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms between 7 and 9, i.e. 1,2-heptanediol and 1,2-undecanediol.

[0177] In a more preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the invention, the linear alkanediol is selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms from 7 to 11, i.e. 2,3-heptanediol, 2,3-nonanediol, 2,3-undecanediol or mixtures thereof.

[0178] In an even more preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the invention, the linear alkanediol is selected from the group consisting of 2,3-nonanediol, 2,3-undecanediol, and mixtures thereof.

[0179] Surprisingly, the use of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, and 2,3-tridecanediol in combination with an antimicrobial component produces an enhanced, i.e., synergistically enhanced, antimicrobial effect by inhibiting the growth of microorganisms on mammalian skin or mucous membranes. Furthermore, application of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol exhibits a significant sebum-reducing effect, which is even more enhanced than the corresponding single 1,2-alkanediol substance. Inhibition of sebum production by the sebaceous glands can reduce microorganisms on the skin, which indirectly supports, for example, a reduction in dandruff or acne. This sebum-reducing effect is demonstrated in the examples below.

[0180] Additionally, the 2,3-alkanediols identified above have the advantage that they are liquids, which can facilitate their incorporation into semi-finished or final products. Furthermore, due to their better solubility, the 2,3-alkanediols can be provided at higher concentrations in the final formulation.

[0181] Thus, when combining active antimicrobial mixtures, a good compromise can be achieved in a manner that maintains antimicrobial and sebum-reducing activity while improving formulation processability. The 2,3-alkanediols identified above solve this balancing problem around solid 1,2-alkanediol materials.

[0182] In a particularly advantageous variant according to the second aspect of the invention, the linear alkanediol or the first alkanediol or the second alkanediol is a liquid alkanediol.

[0183] The term "liquid alkanediol" means, in the context of the present invention, an alkanediol component that is liquid at room or ambient temperature and under normal pressure, i.e., under standard RTP conditions.

[0184] In a highly preferred variant according to the second aspect of the invention, the linear alkanediol or the first alkanediol or the second alkanediol is a liquid alkanediol selected from the group consisting of 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, and mixtures thereof.

[0185] Of the aforementioned alkanediols, 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, or mixtures thereof are most preferred.

[0186] In a most particularly advantageous variant according to the second aspect of the invention, the linear alkanediol or the first alkanediol or the second alkanediol is characterized by a maximum water solubility of less than or equal to 10% by weight. In a preferred variant, the maximum water solubility of the linear alkanediol or the first alkanediol or the second alkanediol is less than or equal to 10% by weight and greater than or equal to 1.2% by weight. More preferably, the maximum water solubility of the linear alkanediol or the first linear alkanediol or the second linear alkanediol is less than or equal to 5% by weight and greater than or equal to 1.4% by weight.

[0187] Preferably, the water-soluble alkanediol is selected from the group consisting of 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, and mixtures thereof.

[0188] The aqueous solubility of a substance is the saturated mass concentration of the substance in water at a given temperature. The determination of solubility in water relates to essentially pure substances that are stable and non-volatile in water. The determination of aqueous solubility of alkanediols is further described in Example 5 below.

[0189] The term "alkanediol" in the context of the present invention also includes its stereoisomers. Stereoisomers are molecules that have the same molecular formula but differ only in how their atoms are arranged in three-dimensional space. According to the definition, the linear alkanediols of the present invention and the first alkanediol having a carbon chain of 5 to 14 carbon atoms or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms, as described in detail above, encompass the following stereoisomers:

[0190] 1,2-Alkanediol Stereoisomers: (2S)-pentane-1,2-diol, (2S)-hexane-1,2-diol, (2S)-heptane-1,2-diol, (2S)-octane-1,2-diol, (2S)-nonane-1,2-diol, (2S)-decane-1,2-diol, (2S)-Undecane-1,2-diol (2S)-dodecane-1,2-diol, (2S)-tridecane-1,2-diol, (2S)-tetradecane-1,2-diol, (2R)-pentane-1,2-diol, (2R)-hexane-1,2-diol, (2R)-heptane-1,2-diol, (2R)-octane-1,2-diol, (2R)-nonane-1,2-diol, (2R)-decane-1,2-diol, (2R)-undecane-1,2-diol, (2R)-dodecane-1,2-diol, (2R)-tridecane-1,2-diol, (2R)-tetradecane-1,2-diol,

[0191] 2,3-Alkanediol Stereoisomers: (2S,3S)-pentane-2,3-diol, (2S,3S)-hexane-2,3-diol, (2S,3S)-heptane-2,3-diol, (2S,3S)-octane-2,3-diol, (2S,3S)-nonane-2,3-diol, (2S,3S)-decane-2,3-diol, (2S,3S)-Undecane-2,3-diol (2S,3S)-dodecane-2,3-diol, (2S,3S)-tridecane-2,3-diol, (2S,3S)-tetradecane-2,3-diol, (2R,3R)-pentane-2,3-diol, (2R,3R)-hexane-2,3-diol, (2R,3R)-heptane-2,3-diol, (2R,3R)-octane-2,3-diol, (2R,3R)-nonane-2,3-diol, (2R,3R)-decane-2,3-diol, (2R,3R)-undecane-2,3-diol, (2R,3R)-dodecane-2,3-diol, (2R,3R)-tridecane-2,3-diol, (2R,3R)-tetradecane-2,3-diol, (2S,3R)-pentane-2,3-diol, (2S,3R)-hexane-2,3-diol, (2S,3R)-heptane-2,3-diol, (2S,3R)-octane-2,3-diol, (2S,3R)-nonane-2,3-diol, (2S,3R)-decane-2,3-diol, (2S,3R)-undecane-2,3-diol, (2S,3R)-dodecane-2,3-diol, (2S,3R)-tridecane-2,3-diol, (2S,3R)-tetradecane-2,3-diol, (2R,3S)-pentane-2,3-diol, (2R,3S)-hexane-2,3-diol, (2R,3S)-heptane-2,3-diol, (2R,3S)-octane-2,3-diol, (2R,3S)-nonane-2,3-diol, (2R,3S)-decane-2,3-diol, (2R,3S)-undecane-2,3-diol, (2R,3S)-dodecane-2,3-diol, (2R,3S)-tridecane-2,3-diol, and (2R,3S)-Tetradecane-2,3-diol.

[0192] 3,4-Alkanediol Stereoisomers: (3R,4R)-hexane-3,4-diol, (3R,4R)-heptane-3,4-diol, (3R,4R)-octane-3,4-diol, (3R,4R)-nonane-3,4-diol, (3R,4R)-decane-3,4-diol, (3R,4R)-undecane-3,4-diol, (3R,4R)-dodecane-3,4-diol, (3R,4R)-tridecane-3,4-diol, (3R,4R)-tetradecane-3,4-diol, (3S,4S)-hexane-3,4-diol, (3S,4S)-heptane-3,4-diol, (3S,4S)-octane-3,4-diol, (3S,4S)-nonane-3,4-diol, (3S,4S)-decane-3,4-diol, (3S,4S)-undecane-3,4-diol, (3S,4S)-dodecane-3,4-diol, (3S,4S)-tridecane-3,4-diol, (3S,4S)-tetradecane-3,4-diol, (3R,4S)-hexane-3,4-diol, (3R,4S)-heptane-3,4-diol, (3R,4S)-octane-3,4-diol, (3R,4S)-nonane-3,4-diol, (3R,4S)-decane-3,4-diol, (3R,4S)-undecane-3,4-diol, (3R,4S)-dodecane-3,4-diol, (3R,4S)-tridecane-3,4-diol, (3R,4S)-tetradecane-3,4-diol, (3S,4R)-hexane-3,4-diol, (3S,4R)-heptane-3,4-diol, (3S,4R)-octane-3,4-diol, (3S,4R)-nonane-3,4-diol, (3S,4R)-decane-3,4-diol, (3S,4R)-undecane-3,4-diol, (3S,4R)-dodecane-3,4-diol, (3S,4R)-tridecane-3,4-diol, and (3S,4R)-Tetradecane-3,4-diol.

[0193] In a preferred variant, the cosmetic or pharmaceutical composition according to the invention does not contain 1,2-decanediol.

[0194] In the context of the present invention, the terms "1,2-diol", "2,3-diol" or "3,4-diol" include both the corresponding S-configuration enantiomer and the R-enantiomer, as well as any mixture of these S- and R-configuration enantiomers, i.e., as a racemic mixture of the respective diol.

[0195] The alkanediol mixture of the cosmetic or pharmaceutical composition according to the first aspect of the present invention comprises 1,2-nonanediol and 2,3-nonanediol in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, and more preferably in a ratio ranging from 90:10 to 95:5.

[0196] In the cosmetic or pharmaceutical composition according to the first aspect of the present invention, 1,2-nonanediol and 2,3-nonanediol are preferably contained in the mixture in a ratio ranging from 98:2 to 99.9:0.1.

[0197] Preferably, 1,2-nonanediol and 2,3-nonanediol are present in the mixture of the cosmetic or pharmaceutical composition according to the first aspect of the present invention in a ratio of ≧95:≦5, more preferably ≧96:≦4, even more preferably ≧97:≦3, and most preferably ≧98:≦2.

[0198] The majority of all mixtures of cosmetic or pharmaceutical compositions according to the first aspect of the present invention comprise 1,2-nonanediol and 2,3-nonanediol in a ratio in the range of ≧95:≦5, including ratios of ≧95.5:≦4.5, ≧96:≦4, ≧96.5:≦3.5, ≧97:≦3, ≧97.5:2.5 and ≧98.0:≦2.0.

[0199] An even more preferred alkanediol mixture for the cosmetic or pharmaceutical composition according to the first aspect of the present invention is a mixture of 1,2-nonanediol and 2,3-nonanediol in the following ratios: ≧98.1:≦1.9, ≧98.2:≦1.8, ≧98.3:≦1.7, ≧98.4:≦1.6, ≧98.5:≦1.5, ≧98.6:≦1.4, ≧98.7:≦1.3, ≧ Including ratios in the range ≥98:≤2, including ratios of 98.8:≤1.2, ≥98.9:≤1.1, ≥99:≤1.0, ≥99.1:≤0.9, ≥99.2:≤0.8, ≥99.3:≤0.7, ≥99.4:≤0.6, ≥99.5:≤0.5, ≥99.6:≤0.4, ≥99.7:≤0.3, ≥99.8:≤0.2 and ≥99.9:≤0.1.

[0200] The first linear alkanediol and the second linear alkanediol as defined in detail above are present in the alkanediol mixture according to the second aspect of the invention in a ratio in the range of 50:50 to 99.9:0.1, preferably in a ratio in the range of 75:25 to 99:1, more preferably in a ratio in the range of 80:20 to 98:2 and more preferably in a ratio in the range of 90:10 to 95:5.

[0201] In the cosmetic or pharmaceutical preparation according to the second aspect of the invention, the first linear alkanediol and the second linear alkanediol are preferably present in the mixture in a ratio ranging from 98:2 to 99.9:0.1.

[0202] Preferably, the first linear alkanediol and the second alkanediol are present in the mixture of the cosmetic or pharmaceutical composition according to the second aspect of the present invention in a ratio in the range of ≧95:≦5, more preferably in a ratio of ≧96:≦4, also more preferably in a ratio of ≧97:≦3, and most preferably in a ratio of ≧98:≦2.

[0203] The majority of all mixtures of the cosmetic or pharmaceutical composition according to the second aspect of the present invention comprise a first linear alkanediol and a second linear alkanediol in a ratio of ≧95:≦5, including ratios of ≧95.5:≦4.5, ≧96:≦4, ≧96.5:≦3.5, ≧97:≦3, ≧97.5:2.5 and ≧98.0:≦2.0.

[0204] Even more preferably, the alkanediol mixture of the cosmetic or pharmaceutical composition according to the second aspect of the present invention comprises a first linear alkanediol and a second linear alkanediol in the ratios ≧98.1:≦1.9; ≧98.2:≦1.8; ≧98.3:≦1.7; ≧98.4:≦1.6; ≧98.5:≦1.5; ≧98.6:≦1.4; ≧98.7:≦1. .3;≧98.8:≦1.2;≧98.9:≦1.1;≧99:≦1.0;≧99.1:≦0.9;≧99.2:≦0.8;≧99.3:≦0.7;≧99.4:≦0.6;≧99.5:≦0.5;≧99.6:≦0.4;≧99.7:≦0.3;≧99.8:≦0.2 and ≧99.9:≦0.1, inclusive, in ratios of ≧98:≦2.

[0205] Alternatively, the ratio ranges for the first alkanediol and the second alkanediol are switched so that the second alkanediol is the major component and the first alkanediol is the minor component.

[0206] In an advantageous variant according to the second aspect of the invention, the mixture comprises, as the first linear alkanediol, a 1,2-alkanediol, such as 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, and, as the second linear alkanediol, a corresponding 2,3-alkanediol, such as For example, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, and more preferably in a ratio ranging from 90:10 to 95:5.

[0207] Similarly, for said mixtures, the ratio of first linear alkanediol to second alkanediol or ranges as described above are also applicable.

[0208] In yet a further variant according to the second aspect of the invention, the mixture comprises as the first linear alkanediol a 2,3-alkanediol, such as 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, and as the second linear alkanediol a corresponding 1,2-alkanediol, For example, it contains 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, and even more preferably in a ratio ranging from 90:10 to 95:5.

[0209] Similarly, for the mixture, the ratio of first linear alkanediol:second alkanediol or ratio ranges described above are also applicable.

[0210] In a more advantageous variant according to the second aspect of the invention, a mixture comprising a combination of a 1,2-alkanediol as the first linear alkanediol and a corresponding 2,3-alkanediol as the second linear alkanediol, such as 1,2-pentanediol and 2,3-pentanediol, or 1,2-hexanediol and 2,3-hexanediol, or 1,2-heptanediol and 2,3-heptanediol, or 1,2-octanediol and 2,3-octanediol, or 1,2-nonanediol and 2,3-nonanediol, or 1,2-decanediol and 2,2-decanediol, or 1,2-undecanediol and 2,3-undecanediol, or 1,2-dodecanediol and 2,3-dodecanediol, or 1,2-tridecanediol and 2,3-tridecanediol, wherein the first linear alkanediol and the second linear alkanediol are present in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, and even more preferably in a ratio ranging from 90:10 to 95:5.

[0211] Similarly, for said mixtures, the ratio of first linear alkanediol:second alkanediol or ratio ranges as described above are also applicable.

[0212] With these mixing ratios, the above mixtures exhibit synergistic antimicrobial and sebum-reducing effects compared to the corresponding individual substances, as described and demonstrated in the experimental section below.

[0213] In a more advantageous variant according to the second aspect of the invention, a mixture comprising a 2,3-alkanediol as the first linear alkanediol and a corresponding 1,2-alkanediol as the second linear alkanediol, e.g. 2,3-pentanediol and 1,2-pentanediol, or 2,3-hexanediol and 1,2-hexanediol, or 2,3-heptanediol and 1,2-heptanediol, or 2,3-octanediol and 1,2-octanediol, or 2,3-nonanediol and 1,2-nonanediol, or 2,3-decanediol and 1,2-decanediol, or 2,3-undecanediol and 1,2-undecanediol, or 2,3-dodecanediol and 1,2-dodecanediol, or 2,3-tridecanediol and 1,2-tridecanediol, In the mixture comprising the first linear alkanediol and the second linear alkanediol, the first linear alkanediol and the second linear alkanediol are present in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, or also more preferably in a ratio ranging from 90:10 to 95:5.

[0214] Similarly, for said mixtures, the ratio of first linear alkanediol:second alkanediol or ratio ranges as described above are also applicable.

[0215] With these mixing ratios, the above mixtures exhibit synergistic antimicrobial and sebum-reducing effects compared to the corresponding individual substances, as described and demonstrated in the experimental section below.

[0216] In a most preferred variant according to the second aspect of the invention, the mixture comprises 1,2-nonanediol or 1,2-undecanediol or 1,2-tridecanediol as the first linear alkanediol and 2,3-nonanediol or 2,3-undecanediol or 2,3-tridecanediol as the second linear alkanediol in a ratio in the range of 50:50 to 99.9:0.1, preferably in a ratio in the range of 75:25 to 99:1, more preferably in a ratio in the range of 80:20 to 98:2 and more preferably in a ratio in the range of 90:10 to 95:5.

[0217] Similarly, for said mixtures, the ratio of first linear alkanediol:second alkanediol or ratio ranges as described above are also applicable.

[0218] In a very most preferred variant according to the second aspect of the present invention, the mixture comprises 2,3-nonanediol or 2,3-undecanediol or 2,3-tridecanediol as the first linear alkanediol and 1,2-nonanediol or 1,2-undecanediol or 1,2-tridecanediol as the second linear alkanediol in a ratio in the range from 50:50 to 99.9:0.1, preferably in a ratio in the range from 75:25 to 99:1, more preferably in a ratio in the range from 80:20 to 98:2 and more preferably in a ratio in the range from 90:10 to 95:5.

[0219] Similarly, for said mixtures, the ratio of first linear alkanediol:second alkanediol or ratio ranges as described above are also applicable.

[0220] Preferred variants according to the second aspect of the invention also include mixtures comprising 1,2-hexanediol as the first linear alkanediol and 2,3-octanediol as the second linear alkanediol, or mixtures comprising 1,2-octanediol as the first linear alkanediol and 2,3-hexanediol as the second linear alkanediol, or mixtures comprising 1,2-octanediol as the first linear alkanediol and 2,3-heptanediol as the second linear alkanediol, in a ratio in the range of 50:50 to 99.9:0.1, preferably in a ratio in the range of 75:25 to 99:1, more preferably in a ratio in the range of 80:20 to 98:2, or also more preferably in a ratio in the range of 90:10 to 95:5.

[0221] Similarly, for said mixtures, the ratio of first linear alkanediol:second alkanediol or ratio ranges as described above are also applicable.

[0222] With these mixing ratios, the above mixtures exhibit synergistic antimicrobial and sebum-reducing effects compared to the corresponding individual substances, as described and demonstrated in the experimental section below.

[0223] In a further advantageous variant according to the second aspect of the invention, the mixture comprises a first linear alkanediol and a second linear alkanediol, for example 1,2-pentanediol and 2,3-hexanediol, or 1,2-pentanediol and 1,2-heptanediol, or 1,2-pentanediol and 2,3-heptanediol, or 1,2-pentanediol and 2,3-octanediol, or 1,2-pentanediol and 1,2-nonanediol, or 1,2-pentanediol and 2,3-nonanediol, In these mixtures, the first linear alkanediol and the second linear alkanediol are present in a ratio ranging from 50:50 to 99.9:0.1, preferably from 75:25 to 99:1, more preferably from 80:20 to 98:2, or also more preferably from 90:10 to 95:5.

[0224] Similarly, for said mixtures, the ratio of first linear alkanediol:second alkanediol or ratio ranges as described above are also applicable.

[0225] With these mixing ratios, the above mixtures exhibit synergistic antimicrobial and sebum-reducing effects compared to the corresponding individual substances, as described and demonstrated in the experimental section below.

[0226] Particularly preferred variants according to the second aspect of the invention are also mixtures comprising 1,2-heptanediol as the first linear alkanediol and 1,2-octanediol as the second linear alkanediol, or mixtures comprising 1,2-heptanediol as the first linear alkanediol and 2,3-octanediol as the second linear alkanediol, or mixtures comprising 1,2-heptanediol as the first linear alkanediol and 1,2-octanediol as the second linear alkanediol. nonanediol, or a mixture comprising 1,2-heptanediol as the first linear alkanediol and 2,3-nonanediol as the second linear alkanediol, wherein the first linear alkanediol and the second linear alkanediol are present in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, or also more preferably in a ratio ranging from 90:10 to 95:5.

[0227] Similarly, for said mixtures, the ratio of first linear alkanediol:second alkanediol or ratio ranges as described above are also applicable.

[0228] With these mixing ratios, the above mixtures exhibit synergistic antimicrobial and sebum-reducing effects compared to the corresponding individual substances, as described and demonstrated in the experimental section below.

[0229] Alkanediols can be obtained from petrochemical or other fossil fuel sources by known methods, such as synthesis by olefin bishydroxylation, hydrolysis from epoxides or various chemical transformations, or from biologically derived feedstocks by fermentation, or from bio-based natural and renewable feedstocks, such as biomass, by catalytic synthesis, as described in US 2019 / 0241491 A1 and US 2020 / 0189995 A1. The alkanediols used in the present invention include both petrochemical-derived alkanediols and alkanediols derived from bio-based natural and renewable feedstocks. Preferably, the alkanediol is from a bio-based source and is therefore a bioalkanediol.

[0230] Component (b) of the cosmetic or pharmaceutical composition according to the first or second aspect of the present invention relates to an antimicrobial component, which is used in many cosmetic compositions, in particular in skin care, hair care or body care, or for pharmaceutical compositions.

[0231] The term "antimicrobial agent" or "antimicrobial component" is a general term that refers to a group of agents or substances that kill or stop the growth of microorganisms. Antimicrobial agents or antimicrobial substances can be grouped by the microorganisms they primarily act on. For example, antibiotics are used against bacteria, antifungals are used against fungi, antiprotozoans are used against protozoans, and antivirals are used against viruses. They can also be classified by their functional group. Agents that kill microorganisms are classified as bactericidal or microbiocidal, while agents that simply inhibit their growth are called biostatic.

[0232] The antimicrobial components according to the present invention act primarily against microorganisms, in particular bacteria and / or fungi of the natural microbial population of mammalian skin or mucous membranes, preferably including but not limited to Staphylococcus, Corynebacterium, Anaerococcus, Finegoldia, Moraxella, Porphyromonas, Fusobacterium, Aspergillus, Candida, Malassezia. The microorganisms are selected from the group consisting of microorganisms of the genera: Escherichia, Peptoniphilus, Streptococcus, Lactobacillus, Gardnerella, Fannyhessea, Epidermophyton, Trichophyton, Cutibacterium, and combinations thereof.

[0233] More preferably, the microorganism is selected from the group consisting of Staphylococcus epidermidis, Staphylococcus hominis, Corynebacterium xerosis, Corynebacterium jeikeium, Anaerococcus Octavius, Finegoldia magna, Moraxella osloensis, Moraxella atlantae, Porphyromonas gingivalis, Aspergillus brasiliensis, Candida albicans, Escherichia coli, Staphylococcus aureus, Peptoniphilus lacrimalis, Streptococcus agalactiae, Lactobacillus acidophilus, Gardnerella vaginalis, Fannyhessea vaginae (Atopobium vaginae), Epidermophyton floccosum, Trichophyton rubrum, Streptococcus mutans, Fusobacterium nucleatum, and combinations thereof.

[0234] The cosmetic or pharmaceutical composition according to the first or second aspect of the present invention may comprise any of the following ingredients: phenoxyethanol, farnesol, bisabolol, ethylhexylglycerin, triethyl citrate, hydroxyacetophenone, benzyl alcohol, 2-methyl-5-cyclohexylpentanol, benzoic acid, sorbic acid, dehydroacetic acid, sorbitan caprylate, caprylhydroxamic acid, dimethylphenylbutanol, dimethylphenylpropanol, levulinic acid and its esters and / or ketals, anisic acid, 2-benzylheptanol, caprylic / capric triglyceride, hydroxybenzoates ... Polyglyceryl-3 Laurate, Polyglyceryl-10 Laurate, Glyceryl Caprate, Polyglyceryl-2 Caprate, Zinc Ricinoleate, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Salvia Officinalis (Sage) Oil, Tropolone, Piroctone Olamine, Triclosan, Triclocarban, Chloroxylenol, Chlorocresol, Benzalkonium Chloride, Benzalkonium Bromide, Benzalkonium Saccharinate, Benzethonium Chloride, Chlorphenesin, Alkyl (C12-22) Trimethylammonium Bromide and Chloride, Zinc Pyrithione, Climbazole, Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, Chlorhexidine Dihydrochloride, Hexamidine, Hexamidine Diisethionate, Silver Chloride, Silver Citrate, Hexylglycerin, Cyclohexylglycerin, Glycerin, Tetraselmis Suesica (Tetraselmis)suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, zinc citrate, cetylpyridinium chloride, menthol, eucalyptol, methyl salicylate, ethanol, camphor, polyarginine, polylysine, gluconic acid and its salts, ascorbic acid and its salts, benzyl salicylate, disodium EDTA, methylparaben and its salts, benzoic acid Sodium benzoate, potassium sorbate, propylparaben, methylchloroisothiazolinone, methylisothiazolinone, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, itaconic acid and its salts, propanediol caprylate, 4-hydroxyacetophenone, iodopropynyl butylcarbamate, isobutylparaben, sodium ethylparaben, diazolidinyl urea, glyceryl caprylate, sodium phytate, or Phytic acid, sodium levulinate or levulinic acid and its esters and / or ketals, TEA salicylate, phenethyl alcohol, tetrasodium glutamate diacetate, trisodium ethylenediaminedisuccinate, sodium lactate, 4-hydroxybenzoic acid and its salts and esters, thyme oil, eugenol, clove oil, mint oil, DMC, antibacterial fragrance, frangipane, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, and at least one antimicrobial component selected from the group consisting of 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components.

[0235] In a preferred variant, the cosmetic or pharmaceutical composition according to the first or second aspect of the invention comprises at least one of the following compounds: phenoxyethanol, farnesol, ethylhexylglycerin, triethyl citrate, hydroxyacetophenone, benzyl alcohol, 2-methyl-5-cyclohexylpentanol, benzoic acid, sorbic acid, dehydroacetic acid, sorbitan caprylate, caprylhydroxamic acid, dimethylphenylbutanol, dimethylphenylpropanol, levulinic acid and its esters and / or ketals, anisic acid, 2-benzylheptanol, Polyglyceryl-3 Caprylate, Polyglyceryl-10 Laurate, Glyceryl Caprate, Polyglyceryl-2 Caprate, Zinc Ricinoleate, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Salvia Officinalis (Sage) Oil, Tropolone, Piroctone Olamine, Triclosan, Triclocarban, Chloroxylenol, Chlorocresol, Benzalkonium Chloride, Benzalkonium Bromide, Benzalkonium Saccharinate, Benzethonium Chloride, Chlorphenesin, Alkyl (C12-22) Trimethylammonium Bromide and Chloride, Zinc Pyrithione, Climbazole, Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, Chlorhexidine Dihydrochloride, Hexamidine, Hexamidine Diisethionate, Silver Chloride, Silver Citrate, Hexylglycerin, Cyclohexylglycerin, Glycerin, Tetraselmis Suesica (Tetraselmissuecica) extract, mannitol, sorbitol, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, zinc citrate, cetylpyridinium chloride, menthol, eucalyptol, methyl salicylate, ethanol, camphor, polyarginine, polylysine, gluconic acid and its salts, ascorbic acid and its salts, benzyl salicylate, disodium EDTA, methylparaben and its salts Sodium benzoate, potassium sorbate, propylparaben, methylchloroisothiazolinone, methylisothiazolinone, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, itaconic acid and its salts, propanediol caprylate, 4-hydroxyacetophenone, iodopropynyl butylcarbamate, isobutylparaben, sodium ethylparaben, diazolidinyl urea, glyceryl caprylate, phytic acid Sodium or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketals, TEA salicylate, phenethyl alcohol, tetrasodium glutamate diacetate, trisodium ethylenediaminedisuccinate, sodium lactate, 4-hydroxybenzoic acid and its salts and esters, thyme oil, eugenol, clove oil, mint oil, DMC, antibacterial fragrance, frangipanione, xylityl caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxybenzoic acid, 3-hydroxypropyl benzoate The antimicrobial composition includes at least one antimicrobial component selected from the group consisting of hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components.

[0236] In a preferred variant, the antimicrobial component of the cosmetic or pharmaceutical composition of the invention is selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid and its salts, caprylic / capric triglyceride, sorbic ... Polyglyceryl-2 Phosphate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Ethyl Laurate, Cocoyl Ethyl Arginate PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the aforementioned antimicrobial components.

[0237] In a preferred variant, the antimicrobial component of the cosmetic or pharmaceutical composition of the invention is selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid and its esters and / or ketals. Salt, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl benzoate and mixtures of two or more of the foregoing antimicrobial components.

[0238] In a particularly preferred variant, the antimicrobial component of the cosmetic or pharmaceutical composition of the invention is selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate. The antimicrobial components are selected from the group consisting of butyl ether, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components.

[0239] In an even more preferred variant, the antimicrobial component of the cosmetic or pharmaceutical composition according to the first or second aspect of the invention is selected from the group consisting of 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the aforementioned antimicrobial components. When the antimicrobial component (b) of the cosmetic or pharmaceutical composition according to the first and second aspects of the invention is an alkanediol, the antimicrobial alkanediol component (b) is different from the alkanediol component (a).

[0240] The aforementioned antimicrobial components can be used as single components or in combination with one or more additional antimicrobial components identified above. To enhance antimicrobial activity and cover a broader spectrum of antimicrobial activity, combinations of two or more antimicrobial components are preferably used.

[0241] In a preferred and advantageous variant, the cosmetic or pharmaceutical composition according to the first or second aspect of the invention comprises one of the following combinations of components (a) and (b): 1,2-pentanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid, and and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 1,2-hexanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid, and and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 1,2-heptanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid, and and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 1,2-octanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid, and and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 1,2-nonanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, aniline, Acid and its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate ter, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components;or; 1,2-Decanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid, and and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 1,2-undecanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 1,2-dodecanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid, and and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 1,2-tridecanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 2,3-pentanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid, and and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 2,3-hexanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid, and and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 2,3-heptanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid, and and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 2,3-octanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid, and and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 2,3-nonanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid, and and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 2,3-Decanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid, and and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 2,3-undecanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 2,3-dodecanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid, and and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 2,3-tridecanediol and one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketals, anisic acid and its salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or combinations of 1,2-pentanediol with 2,3-pentanediol and, in addition to the above, one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 1,2-Hexanediol in combination with 2,3-hexanediol and, in addition to the above, one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or combinations of 1,2-heptanediol and 2,3-heptanediol with one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 1,2-octanediol in combination with 2,3-octanediol and, in addition to the above, one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or Combinations of 1,2-nonanediol and 2,3-nonanediol with one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketones. Tar, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or Combinations of 1,2-decanediol and 2,3-decanediol with one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketones. Tar, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or Combinations of 1,2-undecanediol and 2,3-undecanediol with one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or combinations of 1,2-dodecanediol and 2,3-dodecanediol with one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or Combinations of 1,2-tridecanediol and 2,3-tridecanediol with one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or Combinations of 1,2-heptanediol with one or more of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, caprylic / capric triglyceride, glyceryl-10 laurate, caprylic / capric triglyceride ... Glyceryl Caprylate, Benzyl Alcohol, Benzoic Acid, Sorbic Acid, Levulinic Acid and Its Esters and / or Ketals, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Ethyl Lauroyl Arginate Laurate, Ethyl Cocoyl Arginate PCA, Salvia Officinalis (Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis suecica Extract, Mannitol, Sorbitol, Lactic Acid, Sodium Lauroyl Lactylate, Sodium Caproyl Lactylate, Salicylic Acid and Its Salts, Capryloyl Glycine, Ethyl Lauroyl Arginate HCl, Thymol, Jasmol, Gluconic Acid and Its Salts, Benzyl Salicylate, Propanediol Caprylate, 4-Hydroxyacetophenone, Furanbinone, Xylityl Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3-Hydroxypropyl Ester, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-heptanediol with one or more of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl laurate Benzyl-10, Glyceryl Caprylate, Benzyl Alcohol, Benzoic Acid, Sorbic Acid, Levulinic Acid and Its Esters and / or Ketals, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Ethyl Lauroyl Arginate Laurate, Ethyl Cocoyl Arginate PCA, Salvia Officinalis (Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis suecica Extract, Mannitol, Sorbitol, Lactic Acid, Sodium Lauroyl Lactylate, Sodium Caproyl Lactylate, Salicylic Acid and Its Salts, Capryloyl Glycine, Ethyl Lauroyl Arginate HCl, Thymol, Jasmol, Gluconic Acid and Its Salts, Benzyl Salicylate, Propanediol Caprylate, 4-Hydroxyacetophenone, Furanbinone, Xylityl Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3-Hydroxypropyl Ester, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-nonanediol with one or more of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, caprylic / capric triglyceride, glyceryl-10 laurate, caprylic / capric triglyceride ... Glyceryl Caprylate, Benzyl Alcohol, Benzoic Acid, Sorbic Acid, Levulinic Acid and Its Esters and / or Ketals, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Ethyl Lauroyl Arginate Laurate, Ethyl Cocoyl Arginate PCA, Salvia Officinalis (Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis suecica Extract, Mannitol, Sorbitol, Lactic Acid, Sodium Lauroyl Lactylate, Sodium Caproyl Lactylate, Salicylic Acid and Its Salts, Capryloyl Glycine, Ethyl Lauroyl Arginate HCl, Thymol, Jasmol, Gluconic Acid and Its Salts, Benzyl Salicylate, Propanediol Caprylate, 4-Hydroxyacetophenone, Furanbinone, Xylityl Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3-Hydroxypropyl Ester, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-nonanediol with one or more of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl laurate -10, Glyceryl Caprylate, Benzyl Alcohol, Benzoic Acid, Sorbic Acid, Levulinic Acid and Its Esters and / or Ketals, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Ethyl Lauroyl Arginate Laurate, Ethyl Cocoyl Arginate PCA, Salvia Officinalis (Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis suecica Extract, Mannitol, Sorbitol, Lactic Acid, Sodium Lauroyl Lactylate, Sodium Caproyl Lactylate, Salicylic Acid and Its Salts, Capryloyl Glycine, Ethyl Lauroyl Arginate HCl, Thymol, Jasmol, Gluconic Acid and Its Salts, Benzyl Salicylate, Propanediol Caprylate, 4-Hydroxyacetophenone, Furanbinone, Xylityl Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3-Hydroxypropyl Ester, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-undecanediol with one or more of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-dodecanediol, or 1,2-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, caprylic / capric triglyceride, glyceryl-10 laurate, caprylic / capric triglyceride ... Glyceryl Caprylate, Benzyl Alcohol, Benzoic Acid, Sorbic Acid, Levulinic Acid and Its Esters and / or Ketals, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Ethyl Lauroyl Arginate Laurate, Ethyl Cocoyl Arginate PCA, Salvia Officinalis (Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis suecica Extract, Mannitol, Sorbitol, Lactic Acid, Sodium Lauroyl Lactylate, Sodium Caproyl Lactylate, Salicylic Acid and Its Salts, Capryloyl Glycine, Ethyl Lauroyl Arginate HCl, Thymol, Jasmol, Gluconic Acid and Its Salts, Benzyl Salicylate, Propanediol Caprylate, 4-Hydroxyacetophenone, Furanbinone, Xylityl Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3-Hydroxypropyl Ester, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-undecanediol with one or more of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl laurate Benzyl-10, Glyceryl Caprylate, Benzyl Alcohol, Benzoic Acid, Sorbic Acid, Levulinic Acid and Its Esters and / or Ketals, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Ethyl Lauroyl Arginate Laurate, Ethyl Cocoyl Arginate PCA, Salvia Officinalis (Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis suecica Extract, Mannitol, Sorbitol, Lactic Acid, Sodium Lauroyl Lactylate, Sodium Caproyl Lactylate, Salicylic Acid and Its Salts, Capryloyl Glycine, Ethyl Lauroyl Arginate HCl, Thymol, Jasmol, Gluconic Acid and Its Salts, Benzyl Salicylate, Propanediol Caprylate, 4-Hydroxyacetophenone, Furanbinone, Xylityl Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3-Hydroxypropyl Ester, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-tridecanediol with one or more of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, or 1,2-dodecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, caprylic / capric triglyceride, glyceryl-10 laurate, caprylic / capric triglyceride ... Glyceryl Caprylate, Benzyl Alcohol, Benzoic Acid, Sorbic Acid, Levulinic Acid and Its Esters and / or Ketals, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Ethyl Lauroyl Arginate Laurate, Ethyl Cocoyl Arginate PCA, Salvia Officinalis (Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis suecica Extract, Mannitol, Sorbitol, Lactic Acid, Sodium Lauroyl Lactylate, Sodium Caproyl Lactylate, Salicylic Acid and Its Salts, Capryloyl Glycine, Ethyl Lauroyl Arginate HCl, Thymol, Jasmol, Gluconic Acid and Its Salts, Benzyl Salicylate, Propanediol Caprylate, 4-Hydroxyacetophenone, Furanbinone, Xylityl Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3-Hydroxypropyl Ester, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-tridecanediol with one or more of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl laurate Benzyl-10, Glyceryl Caprylate, Benzyl Alcohol, Benzoic Acid, Sorbic Acid, Levulinic Acid and Its Esters and / or Ketals, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Ethyl Lauroyl Arginate Laurate, Ethyl Cocoyl Arginate PCA, Salvia Officinalis (Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis suecica Extract, Mannitol, Sorbitol, Lactic Acid, Sodium Lauroyl Lactylate, Sodium Caproyl Lactylate, Salicylic Acid and Its Salts, Capryloyl Glycine, Ethyl Lauroyl Arginate HCl, Thymol, Jasmol, Gluconic Acid and Its Salts, Benzyl Salicylate, Propanediol Caprylate, 4-Hydroxyacetophenone, Furanbinone, Xylityl Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3-Hydroxypropyl Ester, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-hexanediol in combination with 2,3-octanediol and one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 1,2-octanediol in combination with 2,3-hexanediol and one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or a combination of 1,2-octanediol and 2,3-heptanediol with one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 1,2-pentanediol in combination with 2,3-hexanediol and one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 1,2-pentanediol in combination with 1,2-heptanediol and, in addition to 1,2-heptanediol, one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or a combination of 1,2-pentanediol and 2,3-heptanediol with one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or a combination of 1,2-pentanediol and 2,3-octanediol with one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or A combination of 1,2-pentanediol with 1,2-nonanediol and, in addition to the above, one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketones. Tar, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or A combination of 1,2-pentanediol and 2,3-nonanediol with one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketones. Tar, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or 1,2-heptanediol in combination with 1,2-octanediol and, in addition to the above, one or more antimicrobial component(s) selected from the group consisting of phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or combinations of 1,2-heptanediol and 2,3-octanediol with one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or Ketal, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or A combination of 1,2-heptanediol and 1,2-nonanediol with one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketones. Tar, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the foregoing antimicrobial components; or Combinations of 1,2-heptanediol and 2,3-nonanediol with one or more antimicrobial component(s) selected from the group consisting of: phenoxyethanol, 2-methyl-5-cyclohexylpentanol, dimethylphenylbutanol, dimethylphenylpropanol, 2-benzylheptanol, ethylhexylglycerin, hydroxyacetophenone, triethyl citrate, polyglyceryl-3 caprylate, polyglyceryl-10 laurate, glyceryl caprylate, benzyl alcohol, benzoic acid, sorbic acid, levulinic acid and its esters and / or ketones. Tar, Anisic Acid and Its Salts, Polyglyceryl-2 Caprate, Caprylhydroxamic Acid, Zinc Ricinoleate, Farnesol, Bisabolol, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Tropolone, Climbazole, Piroctone Olamine, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Sage) Oil, Triclosan, Tetraselmis Suesica (Tetraselmis) suecica) extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, gluconic acid and its salts, benzyl salicylate, propanediol caprylate, 4-hydroxyacetophenone, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and a mixture of two or more of the aforementioned antimicrobial components.

[0242] More preferred combinations of components (a) and (b) in the cosmetic or pharmaceutical composition according to the first or second aspect of the present invention are as follows: 1,2-Pentanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-Hexanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-heptanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-octanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-nonanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-Decanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate, 3-hydroxyanisate hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-Undecanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3- Hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoates, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-Dodecanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-Tridecanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3- Hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoates, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 2,3-Pentanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 2,3-Hexanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate, 3-hydroxyanisate hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 2,3-heptanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 2,3-octanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 2,3-nonanediol and one or more antimicrobial components selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 2,3-Decanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate, 3-hydroxyanisate hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 2,3-Undecanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3- Hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoates, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 2,3-Dodecanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 2,3-Tridecanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3- Hydroxypropyl esters, 3-hydroxypropyl 2-hydroxybenzoates, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-Pentanediol in combination with 2,3-pentanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-Hexanediol in combination with 2,3-hexanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-heptanediol in combination with 2,3-heptanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-octanediol in combination with 2,3-octanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or A combination of 1,2-nonanediol and 2,3-nonanediol with one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or A combination of 1,2-decanediol and 2,3-decanediol with one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-undecanediol and 2,3-undecanediol with one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate. ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-dodecanediol and 2,3-dodecanediol with one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-tridecanediol and 2,3-tridecanediol with one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate. ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-heptanediol in combination with one or more of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, salicylic acid benzyl alcohol, benzyl, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-heptanediol with one or more of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts. , benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components, or Combinations of 1,2-nonanediol with one or more of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, salicylic acid ... benzyl, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or combinations of 1,2-nonanediol with one or more of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts; benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-undecanediol with one or more of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-dodecanediol, or 1,2-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, salicylic acid ... benzyl, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-undecanediol with one or more of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts. , benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-tridecanediol with one or more of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, or 1,2-dodecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, salicylic acid ... benzyl, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or Combinations of 1,2-tridecanediol with one or more of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, in addition to one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts. , benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or A combination of 1,2-hexanediol and 2,3-octanediol with one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-octanediol in combination with 2,3-hexanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or A combination of 1,2-octanediol and 2,3-heptanediol with one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-Pentanediol in combination with 2,3-hexanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-Pentanediol in combination with 1,2-heptanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or A combination of 1,2-pentanediol and 2,3-heptanediol with one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or A combination of 1,2-pentanediol and 2,3-octanediol with one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-Pentanediol in combination with 1,2-nonanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate. anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or A combination of 1,2-pentanediol and 2,3-nonanediol with one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate. anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-heptanediol in combination with 1,2-octanediol and one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or A combination of 1,2-heptanediol and 2,3-octanediol with one or more antimicrobial component(s) selected from the group consisting of: ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or 1,2-heptanediol in combination with 1,2-nonanediol and one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components; or A combination of 1,2-heptanediol and 2,3-nonanediol with one or more antimicrobial component(s) selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, phenoxyethanol, caprylhydroxamic acid, farnesol, climbazole, triethyl citrate, benzyl alcohol, o-cymen-5-ol, salicylic acid and its salts, benzyl salicylate, propanediol caprylate, furanbinone, xylityl caprylate, 3-hydroxypropyl benzoate. ester, anisic acid 3-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components.

[0243] The most preferred combinations of components (a) and (b) in the cosmetic or pharmaceutical compositions according to the first or second aspect of the present invention are: 1,2-nonanediol plus ethylhexylglycerin, or 1,2-nonanediol plus 4-hydroxyacetophenone, or 1,2-nonanediol plus glyceryl caprylate, or 1,2-nonanediol plus phenoxyethanol, or 1,2-nonanediol plus caprylhydroxamic acid, or 1,2-nonanediol plus farnesol, or 1,2-nonanediol plus climbazole, or 1,2-nonanediol plus triethyl citrate, or 1,2-nonanediol plus benzyl alcohol, or 1,2-nonanediol plus o-cymen-5-ol, or 1,2-nonanediol plus salicylic acid and its salts, or 1,2-nonanediol plus benzyl salicylate, or · 1,2-nonanediol plus propanediol caprylate.

[0244] Among the above combinations, those containing 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-undecanediol, or 1,2-tridecanediol, or those containing 2,3-alkanediols, in particular 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, provide outstanding antimicrobial properties, i.e., can enhance the antimicrobial action of the antimicrobial components in the ready-to-use composition on the skin or scalp. In particular, the simultaneous use of one or more of the above alkanediols further synergistically enhances the antimicrobial action of the antimicrobial components on the skin. At the same time, the use of one or more of the above-mentioned alkanediols can reduce or inhibit the excessive sebum production of the sebaceous glands of skin or scalp, and / or reduce or inhibit the dandruff on skin, scalp or nails, for example.This sebum-reducing effect is particularly outstanding for the 2,3-alkanediols previously identified.This effect will be demonstrated by the following examples.

[0245] In a preferred and advantageous variant, the cosmetic or pharmaceutical composition according to the first or second aspect of the invention comprises one of the following combinations of components (a) and (b), wherein the antimicrobial component (b) is a 2,3-alkanediol: 1,2-pentanediol plus 2,3-pentanediol, or 1,2-hexanediol plus 2,3-hexanediol, or 1,2-heptanediol plus 2,3-heptanediol, or 1,2-octanediol plus 2,3-octanediol, or 1,2-nonanediol plus 2,3-nonanediol, or 1,2-decanediol plus 2,3-decanediol, or 1,2-undecanediol plus 2,3-undecanediol, or · 1,2-dodecanediol plus 2,3-dodecanediol.

[0246] Such combinations, on the one hand, have in particular a synergistic antimicrobial action and an enhanced sebum secretion inhibitory action, as demonstrated in the examples below.

[0247] Since skin conditions or disorders are usually accompanied by dry skin, scratchy skin, skin lesions or even inflammation, it is also possible, and in some cases advantageous, to combine the cosmetic or pharmaceutical composition, in particular the dermatological composition according to the first or second aspect of the invention, with one or more other active agents, which in some cases may provide one or more additional benefits or effects or may provide an effect via more than one mechanism of action.

[0248] These active agents are preferably selected from the group of agents consisting of sebum reducing agents, anti-acne agents, anti-dandruff agents, anti-inflammatory and / or redness and / or itching relieving agents, odor absorbing and / or antiperspirant active agents, emollients, moisturizing and / or moisture retaining substances, physiological cooling agents, Tetraselmis suecica extracts, or mixtures of two or more of the aforementioned agents, as further described below.

[0249] Sebum-reducing and / or anti-acne agents: The cosmetic or pharmaceutical composition according to the invention preferably further comprises a sebum-reducing and / or anti-acne agent. The sebum reducing and / or anti-acne agent is preferably selected from the group consisting of capryloyl glycine, caprylic propanediol, undecylenoyl glycine, farnesol, retinoids such as 13-cis retinoic acid (isotretinoin), all-trans-retinoic acid, adapalene, salts or derivatives thereof, androgen inhibitors such as spironolactone and cyproterone, antibiotics, preferably clindamycin, erythromycin and tetracycline, zinc or zinc salts, and antiandrogens, 5-alpha-reductase inhibitors, D-panthenol, alpha-hydroxy acids such as salicylic acid and lactic acid, pyruvic acid (alpha-keto acid), aliphatic dicarboxylic acids such as azelaic acid, L-carnitine, bakuchiol, 1,2-decanediol, senkyunolide-A and senkyunolide-A containing Apium graveolens seed oil, Tetraselmis extract, Quillaja saponaria extract, Enantia chlorantha bark extract, Spiraea ulmaria extract, butyl avocate, vitamin B6 (also known as pyridoxine) or a salt or derivative thereof, vitamin B3 (also known as niacin or nicotinic acid) or a salt or derivative thereof, benzoyl peroxide, phloretin, Camellia sinensis extract and those contained in polyphenols such as epigallocatechin 3-gallate, red clover (Trifolium pretense) extract, soybean (Glycine soja) seed extract, isoflavonoids or extracts containing isoflavonoids, preferably selected from the group consisting of biochanin A, genistein, daidzein, genistin, daidzin, and mixtures of two or more of the aforementioned agents.

[0250] Antidandruff substances: Additionally, the cosmetic or pharmaceutical compositions according to the invention may also be used advantageously in combination with one or more antidandruff substances, including triclosan, climbazole, octoxyglycerin, Octirox® (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone 2-aminoethanol salt), chitosan, farnesol, glycerol monolaurate, propanediol monocaprylate or combinations of said substances (among others used against dandruff).

[0251] Further suitable antidandruff substances are Baypival® (climbazole), Ketoconazol® (4-acetyl-1-{4-[2-(2,4-dichlorophenyl)r-2-(1H-imidazol-1-ylmethyl)-1,3-dioxiran-c-4-ylmethoxyphenyl}-piperazine, ketoconazole, elubiol, selenium disulfide, colloidal sulfur, sulfur polyethylene glycol sorbitan monooleate, sulfur ricinol polyethoxylate, sulfur tar distillate, salicylic acid (or in combination with hexachlorophene), undecylenic acid, monoethanolamide sulfosuccinate Na salt, Lamepon® UD (protein / undecylenic acid condensate), zinc pyrithione, aluminum pyrithione, magnesium pyrithione / magnesium dipyrithione sulfide, or a mixture of two or more of the aforementioned substances.

[0252] Anti-inflammatory and / or redness and / or itching relieving agents: The cosmetic or pharmaceutical composition according to the invention also preferably contains an anti-inflammatory and / or redness and / or itching relieving ingredient, in particular steroidal substances of the corticosteroid type selected from the group consisting of hydrocortisone, dexamethasone, dexamethasone phosphate, methylprednisolone or cortisone are advantageously used as anti-inflammatory active ingredients or active ingredients for relieving redness and itching, this list can be expanded by adding other steroidal anti-inflammatory agents. Non-steroidal anti-inflammatory agents can also be used. More particularly: (i) steroidal anti-inflammatory substances of the corticosteroid type, in particular hydrocortisone, hydrocortisone derivatives, such as hydrocortisone 17-butyrate, dexamethasone, dexamethasone phosphate, methylprednisolone or cortisone; (ii) non-steroidal anti-inflammatory substances, in particular oxicams such as piroxicam or tenoxicam, salicylates such as aspirin, disalcid, solprin or fendosal, acetic acid derivatives such as diclofenac, fenclofenac, indomethacin, sulindac, tolmetin or clindanac, fenamic acids such as mefenamic acid, meclofenamic acid, flufenamic acid or niflum, propionic acid derivatives such as ibuprofen, naproxen or benoxaprofen, pyrazoles such as phenylbutazone, oxyphenylbutazone, febrazone or azapropazone, anthranilic acid derivatives, in particular avenanthramide; (iii) natural or naturally occurring anti-inflammatory substances or substances that relieve redness and / or itching, in particular chamomile, aloe vera, Commiphora species, Rubia species, willow, willow herb, oat, calendula, arnica, St. John's walnut, honeysuckle, rosemary, passionflower, witch hazel, ginger or Echinacea, or single active compounds thereof, such as natural alpha-bisabolol, synthetic bisabolol, apigenin, apigenin-7-glucan Cosides, gingerols, shogaols, gingerdiols, dehydrogingediones, paradols, in particular natural or synthetic 6-paradols, naturally occurring avenanthramides, preferably avenanthramide A, avenanthramide B, avenanthramide C, avenanthramide D, avenanthramide E, non-natural or non-naturally occurring avenanthramides, preferably dihydroavenanthramide D, dihydroavenanthramide E, tranilast, boswellic acid, phytosterols, glycyrrhizin, gracilis Extracts or fractions derived from lysine, sclareolide and licochalcone A, preferably natural alpha-bisabolol, synthetic bisabolol, natural avenanthramides, non-natural avenanthramides, preferably dihydroavenanthramide D, ginger extract, gingerol, shogaol, gingerdiol, dehydrogingedione, paradols, in particular natural or synthetic 6-paradol, boswellic acid, phytosterols, glycyrrhizin, and licochalcone A, and / or allantoin, sclareolide and licochalcone A. selected from the group consisting of lareolide, panthenol, (pseudo)ceramides [preferably ceramide 2, hydroxypropyl bispalmitamide MEA, cetyloxypropyl glyceryl methoxypropyl myristamide, N-(l-hexadecanoyl)-4-hydroxy-L-proline (1-hexadecyl) ester, hydroxyethyl palmityloxyhydroxypropyl palmitamide], phytosterols, chitosan, and β-glucans, in particular 1,3-1,4-glucans derived from oat; or (iv) histamine receptor antagonists, serine protease inhibitors (e.g., those from soybean extracts), TRPV1 antagonists (e.g., 4-t-butylcyclohexanol), NK1 antagonists (e.g., aprepitant, hydroxyphenylpropamidobenzoic acid), cannabinoid receptor agonists (e.g., palmitoylethanolamine), and TRPV3 antagonists; or a mixture of two or more of the above drugs.

[0253] Examples that may be cited here are oxicams such as piroxicam or tenoxicam; salicylates such as aspirin, disalcid, solprin or fendosal; acetic acid derivatives such as diclofenac, fenclofenac, indomethacin, sulindac, tolmetin or clindanac; fenamic acids such as mefenamic acid, meclofenamic acid, flufenamic acid or niflum; propionic acid derivatives such as ibuprofen, naproxen, benoxaprofen, or pyrazoles such as phenylbutazone, oxyphenylbutazone, febrazone or azapropazone. Anthranilic acid derivatives are preferred antipruritic ingredients in the compositions according to the invention.

[0254] Also useful are natural or naturally occurring anti-inflammatory mixtures of substances or mixtures of substances that relieve redness and / or itching, especially extracts or fractions from chamomile, aloe vera, Commiphora species, Rubia species, willow, willowherb, oat, calendula, arnica, St. John's wort, honeysuckle, rosemary, passionflower, witch hazel, ginger or Echinacea, preferably chamomile, aloe vera, oat, calendula, arnica, honeysuckle , rosemary, witch hazel, ginger or Echinacea, and / or pure substances, preferably alpha-bisabolol, apigenin, apigenin-7-glucoside, gingerol, shogaol, gingerdiol, dehydrogingedione, paradol, natural or naturally occurring avenanthramides, preferably tranilast, avenanthramide A, avenanthramide B, avenanthramide C, non-natural or non-naturally occurring avenanthramides, preferably dihydroavenanthramide D, dihydroavenanthramide and / or extracts or fractions derived from avenanthramide E, avenanthramide D, avenanthramide E, avenanthramide F, boswellic acid, phytosterols, glycyrrhizin, glabridin and licochalcone A, preferably alpha-bisabolol, natural avenanthramides, non-natural avenanthramides, preferably dihydroavenanthramide D (as described in WO2004047833A1), boswellic acid, phytosterols, glycyrrhizin, and licochalcone A, and / or allantoin, panthenol, lavandin ... Nolin, (pseudo)ceramides [preferably ceramide 2, hydroxypropyl bispalmitamide MEA, cetyloxypropyl glyceryl methoxypropyl myristamide, N-(1-hexadecanoyl)-4-hydroxy-L-proline (1-hexadecyl) ester, hydroxyethyl palmityloxyhydroxypropyl palmitamide], glycosphingolipids, phytosterols, chitosan, mannose, lactose and β-glucans, in particular 1,3→1,4-β-glucan derived from oat.

[0255] When bisabolol is used in the context of the present invention, it can be of natural or synthetic origin, and is preferably "alpha-bisabolol".Preferably, the bisabolol used is synthetically prepared, or natural (-)-alpha-bisabolol and / or synthetic mixed isomer alpha-bisabolol.When natural (-)-alpha-bisabolol is used, it can also be used as a constituent of essential oils, or as a constituent of plant extracts or fractions thereof, for example, as a constituent (fraction) of chamomile oil or extract, or as a constituent (fraction) of Vanillosmopsis (particularly Vanillosmopsis erythropappa or Vanillosmopsis arborea) oil or extract.Synthetic alpha-bisabolol is available, for example, from Symrise under the name "Dragosantol".

[0256] When ginger extract is used in the context of the present invention, fresh or dried ginger root extracts prepared by extraction with methanol, ethanol, isopropanol, acetone, ethyl acetate, carbon dioxide (CO2), hexane, methylene chloride, chloroform or other solvents or solvent mixtures of comparable polarity are preferably used. The extracts are characterized by the presence of active, skin irritation-reducing amounts of constituents such as gingerols, shogaols, gingerdiols, dehydrogingediones and / or paradols.

[0257] Odor absorbers and / or antiperspirant active agents: The cosmetic or pharmaceutical composition according to the present invention may contain one or more odor absorbers and / or antiperspirant active agents (antiperspirants). Suitable odor absorbers are substances capable of absorbing and widely retaining odor-forming compounds. Odor absorbers reduce the partial pressure of individual components, thereby reducing their diffusion rate. It is important that perfumes remain intact during this process. Odor absorbers are not effective against bacteria. These include, for example, as the main component, complex zinc salts of ricinoleic acid, or certain, mainly neutral-smelling fragrances (known to those skilled in the art as "fixatives"), such as labdanum or styrax extracts, or certain abietic acid derivatives. Odor masking agents are perfumes or perfume oils, which, in addition to their function as odor masking agents, impart the scent notes of their respective fragrances to the deodorant. Perfume oils that may be mentioned are, for example, mixtures of natural and synthetic fragrances. Natural fragrances are extracts from flowers, stems and leaves, fruits, fruit peels, roots, wood, herbs and grasses, needles and branches, as well as resins and balsams. Animal products, such as civet and castoreum, are also suitable. Typical synthetic fragrance compounds are ester, ether, aldehyde, ketone, alcohol, and hydrocarbon products. Examples of ester-type fragrance compounds include benzyl acetate, p-tert-butylcyclohexyl acetate, linalyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, allyl cyclohexylpropionate, styrallyl propionate, and benzyl salicylate. Ethers include, for example, benzyl ethyl ether; aldehydes include, for example, linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilial, and borgeonal; ketones include, for example, ionones and methyl cedryl ketone; alcohols include anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol, and terpineol; and hydrocarbons, mainly terpenes and balsams.However, preference is given to using mixtures of different fragrances which together produce a pleasant fragrance note. Essential oils with relatively low volatility are mostly used as fragrance components and are also suitable as perfume oils, such as, for example, sage oil, chamomile oil, clove oil, melissa oil, mint oil, cinnamon leaf oil, linden flower oil, juniper berry oil, vetiver oil, olibanum oil, galbanum oil, labdanum oil and lavandin oil. Bergamot oil, dihydromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol, α-hexylcinnamaldehyde, geraniol, benzyl acetone, cyclamen aldehyde, linalool, boisambrenholt, ambroxan, indole, hedione, sandelice, lemon oil, mandarin oil, orange oil, amylallyl glycolate, cyclovertal, lavandin oil, clary sage oil, β-damascone, geranium oil bourbon, cyclohexyl salicylate, Vertofix coeur, IsoE Super, Fixolide NP, evernyl, iraldein gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romilate, irotyl and florama are preferably used alone or in mixtures.

[0258] Suitable astringent antiperspirant active ingredients are primarily salts of aluminum, zirconium or zinc. Suitable anti-hydrotech active ingredients include, for example, aluminum chloride, aluminum chlorohydrate, aluminum dichlorohydrate, aluminum sesquichlorohydrate and their complex compounds, such as 1,2-propylene glycol, aluminum hydroxyalantoate, aluminum chlorotartrate, aluminum zirconium trichlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate and their complex compounds, for example, their complex compounds with amino acids, for example, with glycine.

[0259] Soothing Substances: The cosmetic or pharmaceutical compositions according to the invention may also advantageously contain one or more soothing substances, and any soothing substance suitable or customary in cosmetic or pharmaceutical applications may be used, such as alpha-bisabolol, azulene, guaiazulene, 18-beta-glycyrrhetinic acid, allantoin, aloe vera juice or gel, extracts of Hamamelis virginiana (witch hazel), Echinacea species, Centella asiatica, chamomile, Arnica monatana, Glycyrrhiza species, algae, seaweed and Calendula officinalis, and vegetable oils such as sweet almond oil, baobab oil, olive oil, and panthenol, laureth-9, trideceth-9 and 4-t-butylcyclohexanol.

[0260] Moisturizing and / or moisture-retaining substances: when the skin is dry, itching occurs with a certain intensity.The use of moisturizing and / or moisture-retaining substances for the skin can significantly alleviate itching.Therefore, the cosmetic or pharmaceutical composition according to the present invention can also advantageously contain one or more of the following moisturizing and / or moisture-retaining substances: sodium lactate, urea, urea derivatives, alcohol, glycerol, diols such as propylene glycol, hexylene glycol, collagen, elastin or hyaluronic acid, diacyl adipate, petrolatum, urocanic acid, lecithin, panthenol, phytantriol, lycopene, (pseudo)ceramide, glycosphingolipid, cholesterol, Phytosterols, chitosan, chondroitin sulfate, lanolin, lanolin esters, amino acids, alpha-hydroxy acids (e.g., citric acid, lactic acid, malic acid) and their derivatives, mono-, di- and oligosaccharides such as glucose, galactose, fructose, mannose, fructose and lactose, polysaccharides such as R-glucans, especially 1,3-1,4-β-glucan from oat, alpha-hydroxy fatty acids, triterpene acids such as betulinic acid or ursolic acid, and algae extracts. Preferred skin moisturizers are alkanediols or alkanetriols containing 3 to 12 carbon atoms, preferably C3-C6.10 -Alkanediols and C3-C 10 More preferably, the skin moisturizer is selected from the group consisting of glycerol, 1,2-propylene glycol, 1,2-butylene glycol, and 1,3-butylene glycol.

[0261] Physiological cooling agents: The cosmetic or pharmaceutical compositions according to the invention can be advantageously combined in particular with one or more physiological cooling agent(s). The use of cooling agents can relieve itching. Individual cooling agents preferred for use within the framework of the present invention are listed below. Those skilled in the art can add many other cooling agents to this list; the listed cooling agents can also be used in combination with one another, and here are preferably selected from the following list: menthol and menthol derivatives (e.g. L-menthol, D-menthol, racemic menthol, isomenthol, neoisomenthol, neomenthol), menthyl ethers (e.g. (l-menthoxy)-1,2-propanediol, (l-menthoxy)-2-methyl-1,2-propanediol, l-menthyl-methyl ether), menthone glyceryl acetal, menthone glyceryl ketal or a mixture of both, menthyl esters (e.g. menthyl formate, menthyl acetate, menthyl isobutyrate, menthyl hydroxyisobutyrate, menthyl lactate, L-menthol ... -menthyl-L-lactic acid, L-menthyl-D-lactic acid, menthyl-(2-methoxy) antiperspirant acetate, menthyl-(2-methoxyethoxy)acetate, menthyl pyro-glutamate), menthyl carbonates (e.g., menthyl propylene glycol carbonate, menthyl ethylene glycol carbonate, menthyl glycerol carbonate or mixtures thereof), semiesters of menthol with dicarboxylic acids or derivatives thereof (e.g., mono-menthyl succinate, mono-menthyl glutarate, mono-menthyl malonate, O-menthyl succinic acid ester-N,N-(dimethyl)amide, O-menthyl succinic acid ester amide), menthanecarboxylic acid amides (in this case preferably menthanecarboxylic acid-N-ethylamide [WS3] or N-methyl-N ... α-(menthanecarbonyl)glycine ethyl ester [WS5], menthanecarboxylic acid-N-(4-cyanophenyl)amide or menthanecarboxylic acid-N-(4-cyanomethylphenyl)amide, menthanecarboxylic acid-N-(alkoxyalkyl)amide, menthone and menthone derivatives (e.g., L-menthone glycerol ketal), 2,3-dimethyl-2-(2-propyl)-butyric acid derivatives (e.g., 2,3-dimethyl-2-(2-propyl)-butyric acid-N-methylamide [WS23]), isopulegol or its esters (I-(-)-isopulegol, I-(-)-isopulegol acetate), menthane derivatives (e.g., p-menthane-3,8-diol), cubol, or synthetic compounds containing cubol or natural mixtures, pyrrolidone derivatives of cycloalkyldione derivatives (e.g., 3-methyl-2(1-pyrrolidinyl)-2-cyclopenten-1-one) or tetrahydropyrimidin-2-ones (e.g., icilin or related compounds, as described in WO 2004 / 026840), as well as carboxamides (e.g., N-(2-(pyridin-2-yl)ethyl)-3-p-menthanecarboxamide or related compounds), (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-isopropyl)cyclohexane-carboxamide [WS12], oxamate and [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl]2-(ethylamino)-2-oxo-acetate (X Cool). Preferred cooling agents due to their particular synergistic effects are l-menthol, d-menthol, racemic menthol, menthone glycerol acetal (trade name: Frescolat® MGA), menthyl lactate (preferably l-menthyl lactate, especially l-menthyl l-lactate (trade name: Frescolat® ML)), substituted menthyl-3-carboxamides (e.g., menthyl-3-carboxylic acid N-ethylamide), 2-isopropyl-N-2,3-trimethylbutanamide, substituted cyclohexanecarboxamides, 3-menthoxypropane-1,2-diol, 2-hydroxyethyl menthyl carbonate, 2-hydroxypropyl menthyl carbonate, and isopulegol.Particularly preferred cooling agents are 1-menthol, racemic menthol, menthone glycerol acetal (trade name: Frescolat® MGA), menthyl lactate (preferably 1-menthyl lactate, especially 1-menthyl 1-lactate (trade name: Frescolat® ML)), 3-menthoxypropane-1,2-diol, 2-hydroxyethyl menthyl carbonate and 2-hydroxypropyl menthyl carbonate. Very particularly preferred cooling agents are l-menthol, menthone glycerol acetal (trade name: Frescolat® MGA) and menthyl lactate (preferably menthyl l-lactate, in particular l-menthyl l-lactate (trade name: Frescolat® ML)), 3-((−)-menthoxy)propane-1,2-diol, N-ethyl-p-menthane-3-carboxamide, menthyl-ethylamidooxalate, and mixtures of two or more of the aforementioned cooling agents.

[0262] Tetraselmis suecica extract: Tetraselmis suecica extract can also be used particularly advantageously in the cosmetic or pharmaceutical compositions of the present invention. Tetraselmis suecica is a marine green microalgae belonging to the Chlorophyceae class and is widely used in aquaculture as food for mollusk and crustacean larvae and as a probiotic for fish. T. suecica is rich in vitamin E, carotenoids, chlorophyll, and tocopherols and has been proposed as a dietary supplement for humans and animals. An ethanol / water extract from T. suecica is known for its ability to enhance skin pigmentation and reduce psoriatic lesions.

[0263] Cosmetic or pharmaceutical compositions, especially dermatological compositions as defined herein, are preferably based on a carrier, which contains at least one oil phase. Thus, oil, oil-in-water and water-in-oil emulsions are suitable. However, preparations based solely on water, water / alcohol or water / glycol are also possible or even preferred.

[0264] Oil phases or oil components of the cosmetic or pharmaceutical compositions according to the invention that may be suitable are, for example, vegetable oils, hydrocarbons, fatty alcohols, fatty acid esters, liquid UV filters, or mixtures of two or more of the aforementioned liquid oil components.

[0265] The oil phase or oil component of the cosmetic or pharmaceutical composition according to the invention is preferably a vegetable oil, even more preferably a liquid vegetable oil. Mixtures of two or more vegetable oil components, in particular liquid vegetable oil mixtures, can also be advantageous.

[0266] Vegetable oils are oils extracted from seeds or, less frequently, from other parts of fruits. Like animal fats, vegetable oils are mixtures of triglycerides. Soybean oil, rapeseed oil, and cocoa butter are examples of vegetable oils derived from seeds. Olive oil, palm oil, and rice bran oil are examples of oils derived from other parts of fruits. In common usage, vegetable oils can refer exclusively to plant fats that are liquid at room temperature or at skin temperature of 35-37°C. Vegetable oils are usually edible.

[0267] The term "vegetable oil" also includes unsaturated vegetable oils. Unsaturated or vegetable oils can be converted to higher melting point oils through partial or complete "hydrogenation." The hydrogenation process involves "sparging" the oil with hydrogen at high temperature and pressure in the presence of a catalyst, usually a powdered nickel compound. Each carbon-carbon double bond is chemically reduced to a single bond, so that two hydrogen atoms each form a single bond with two carbon atoms. The removal of a double bond by adding a hydrogen atom is called saturation. As the degree of saturation increases, the oil moves toward being fully hydrogenated. Hydrogenation can increase an oil's resistance to rancidity (oxidation) or change its physical characteristics. As the degree of saturation increases, the oil's viscosity and melting point increase.

[0268] In a preferred variant, the vegetable oil is selected from the group consisting of Persea Gratissima (Avocado Oil), Abies Alba Seed Oil, Acacia Victoriae Seed Oil, Actinidia Chinensis (Kiwi) Seed Oil, Amaranthus Hypochondriacus Seed Oil, Arachis Hypogaea (Peanut) Oil, Astrocaryum Murumuru Seed Butter, Astrocaryum Tucuma Seed Butter, Astrocaryum Tucuma Seed Oil, Astrocaryum Vulgare Fruit Oil, Astrocaryum Vulgare Kernel Oil, Avena Sativa (Oat) Kernel Oil, Brassica Alba Seed Oil, Brassica Campestris (Rapeseed) Seed Oil, Butyrospermum Parkii (Shea) Butter, Butyrospermum Parkii (Shea) Oil, Calendula Officinalis Seed Oil, Calophyllum Inophyllum Seed Oil, Calophyllum Tacamahaca Seed Oil, Camellia Oleifera (Safflower) Seed Oil, Camellia Reticulata (Camellia) Seed Oil, Camellia Sinensis (Camellia) Seed Oil, Cannabis Sativa (Cannabis Sativa) Seed / Stem Oil, Brassica napus (Olive) Seed Oil, Carthamus Tinctorius (Safflower) Seed Oil, Chlorella Vulgaris (Chlorella) Oil, Citrullus Lanatus (Watermelon) Seed Oil, Citrus Aurantifolia (Lime) Seed Oil, Citrus Aurantium Dulcis (Orange) Seed Oil, Citrus Grandis (Grapefruit) Seed Oil, Cocos Nucifera (Coconut) Oil, Cocos Nucifera (Coconut) Seed Butter, Coffea Arabica (Coffee) Seed Oil, Chlorella (Biotech), Corylus Americana (Hazelnut) Seed Oil, Corylus Avellana (Hazelnut) Seed Oil, Cucumis Melo (Melon) Seed Oil, Cucumis Sativus (Cucumber) Sativus (Cucumber) Seed Oil, Cucurbita Pepo (Pumpkin) Seed Oil, ElaeisGuineensis (Palm) Oil, Elaeis (Palm) Fruit Oil, Glycine Soja (Soybean) Oil, Gossypium Herbaceum (Cotton) Seed Oil, Gossypium Hirsutum (Cotton) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Macadamia Integrifolia Seed Oil, Macadamia Ternifolia Seed Oil, Mangifera Indica (Mango) Seed Butter, Mangifera Indica (Mango) Seed Oil, Melissa Officinalis Seed Oil, Microalgae Oil, Moringa Oleifera Seed Oil, Moringa Peregrina Seed Oil, Oenothera Biennis (Evening Primrose) Oil, Olea Europaea (Olive) Fruit Oil, Olus Oil, Orbignya Oleifera Seed Oil, Orbignya Speciosa Kernel Oil, Oryza Sativa (Rice) Bran / Wheat Germ Oil, Oryza Sativa (Rice) Bran Oil, Oryza Sativa (Rice) Germ Oil, Oryza Sativa (Rice) Lipid, Oryza Sativa (Rice) Seed Oil, Papaver Somniferum Seed Oil, Passiflora Edulis Seed Oil, Persea Gratissima (Avocado) Butter, Persea Gratissima (Avocado) Oil, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Prunus Armeniaca (Apricot) Kernel Oil, Prunus Persica (Peach) Kernel Oil, Punica Granatum Seed Oil, Pyrus Malus (Apple) Seed Oil, Ricinoleic / Caproic / Caprylic / Capric Triglycerides(S), Ricinus Communis (Castor) Seed Oil, Rosa Canina Fruit Oil, Rosa Moschata Seed Oil, Rubus Idaeus (Raspberry) Seed Oil, Sesamum Indicum (Sesame) Seed Butter, Soybean Glycerides, Theobroma Cacao (Cocoa) Seed Butter, Theobroma Grandiflorum Seed Butter, Triticum Vulgare (Wheat) Bran Lipid, Triticum Vulgare (Wheat) Germ Oil, VitisVinifera (grape) seed oil, Zea Mays (corn) germ oil, and Zea Mays (corn) oil.

[0269] In certain preferred variants, the cosmetic or pharmaceutical composition according to the first or second aspect of the invention comprises as oil component a vegetable oil selected from the group consisting of caprylic / capric triglyceride, Helianthus Annuus (Sunflower) seed oil, Simmondsia Chinensis (Jojoba) seed oil, Olea Europaea (Olive) fruit oil, Argania spinosa kernel oil (Argan oil), Prunus Amygdalus Dulcis (Sweet Almond) oil, Persea Gratissima (Avocado oil), Butyrospermum Parkii (Shea) butter, Cocos Nucifera (Coconut) oil, Theobroma Cacao (Cocoa) seed butter, and mixtures of two or more of the aforementioned vegetable oils.

[0270] The vegetable oil can be used as a single component or in a mixture with one or more further different vegetable oils as specified above.

[0271] Hydrocarbons (mineral oils) are organic compounds generally composed entirely of hydrogen and carbon. As defined by the IUPAC nomenclature or organic chemistry, the classification for hydrocarbons is as follows: 1. Saturated hydrocarbons are the simplest hydrocarbon species. They are composed entirely of single bonds and saturated with hydrogen. The formula for acyclic saturated hydrocarbons (i.e., alkanes) is C n H 2n+2 The most common form of saturated hydrocarbon is C n H 2n+2(1-r) where r is the number of rings. Those with exactly one ring are cycloalkanes. Saturated hydrocarbons are the basis of petroleum fuels and are found as either linear or branched species. 2. Unsaturated hydrocarbons have one or more double or triple bonds between carbon atoms. Those with a double bond are called alkenes. Those with one double bond have the formula C n H 2n (assuming it is an acyclic structure). Those containing a triple bond are called alkynes. Those with one triple bond have the formula C n H 2n-2 It has. 3. Aromatic hydrocarbons, also known as arenes, are hydrocarbons that contain at least one aromatic ring.

[0272] Hydrocarbons can be liquids (e.g., hexane and benzene), waxes, or low-melting solids (e.g., paraffin wax and naphthalene), among others. The term "aliphatic" refers to non-aromatic hydrocarbons. Saturated aliphatic hydrocarbons are sometimes called "paraffins." Mineral oils and waxes are mixtures of saturated hydrocarbons, primarily linear, branched, and cyclic structures, with carbon chain lengths greater than C14. Mineral oils and waxes are chemicals prepared from naturally occurring crude petroleum. They consist primarily of mineral saturated hydrocarbons (MOSH) and mineral aromatic hydrocarbons (MOAH). Hydrocarbons have been used in skin care and lip care cosmetic products for decades due to their excellent skin tolerance, high protective and cleansing properties, and a wide range of viscosity options. In contrast to vegetable oils, mineral oils are non-allergenic because they are extremely stable and not prone to oxidation or rancidity.

[0273] In a preferred variant, the hydrocarbons as oil constituents of the cosmetic or pharmaceutical composition of the invention are undecane, tridecane, mineral oil, petrolatum, squalane, isohexadecane, C7-C8 isoparaffins, C8-C9 isoparaffins, C9-C11 isoparaffins, C9-C12 isoparaffins, C9-C13 isoparaffins, C9-C14 isoparaffins, C9-C16 isoparaffins, C10-C11 isoparaffins, C10-C12 isoparaffins The isoparaffin is selected from the group consisting of paraffin, C10 to C13 isoparaffin, C11 to C12 isoparaffin, C11 to C13 isoparaffin, C11 to C14 isoparaffin, C12 to C14 isoparaffin, C12 to C15 isoparaffin, C12 to C20 isoparaffin, C13 to C14 isoparaffin, C13 to C16 isoparaffin, C14 to C16 isoparaffin, C15 to C19 isoparaffin, and C18 to C70 isoparaffin.

[0274] In certain preferred variants, the oil component of the cosmetic or pharmaceutical composition of the present invention is a hydrocarbon selected from the group consisting of hydrocarbons, petrolatum, squalane, isohexadecane, C13-C14 isoparaffins, and mixtures of two or more of the foregoing hydrocarbons.

[0275] The hydrocarbons can be used as single components or in mixtures with one or more further different hydrocarbons as specified above.

[0276] Fatty alcohols (or long-chain alcohols) are usually high-molecular-weight, straight-chain primary alcohols derived from natural fats and oils and can range from as few as 4–6 carbon atoms to as many as 22–26 carbon atoms. The exact chain length varies depending on the source. Some commercially important fatty alcohols are lauryl, stearyl, and oleyl alcohol. They are colorless, oily liquids (for lower carbon numbers) or waxy solids, although impure samples may appear yellow. Fatty alcohols usually have an even number of carbon atoms and a single alcohol group (–OH) attached to the terminal carbon. Some fatty alcohols are unsaturated, and some are branched. Most fatty alcohols in nature are found as waxes, which are esters of fatty acids and fatty alcohols. The traditional source of fatty alcohols is primarily various vegetable oils, which remain in large-scale feedstocks. Alcohols are derived from triglycerides (fatty acid triesters), which form most oils. The process involves transesterifying triglycerides to produce methyl esters, which are then hydrogenated to obtain fatty alcohols. Fatty alcohols are also prepared from petrochemical sources. In the Ziegler process, ethylene is oligomerized using triethylaluminum, followed by air oxidation. Alternatively, ethylene can be oligomerized to produce a mixture of alkenes, which are subjected to hydroformylation (which produces odd-numbered aldehydes) and then hydrogenated. Fatty alcohols are primarily used in the production of detergents and surfactants. They are also components of cosmetic solvents. They also find use as co-emulsifiers, emollients, and thickeners in these cosmetics.

[0277] In a preferred variant, the fatty alcohol as oil component of the cosmetic or pharmaceutical composition of the invention is selected from the group consisting of phenylpropanol, dimethylphenylbutanol, hexyldecanol, octyldodecanol, octyldodecanol, tridecyl alcohol, isostearyl alcohol, phenylisohexanol, phenylpropanol, trimethylbenzenepropanol, isoamyl alcohol, isostearyl alcohol, and isotridecyl alcohol.

[0278] The fatty alcohol can be used as a single component or in a mixture with one or more further different fatty alcohols as specified above.

[0279] Fatty acid esters are a type of ester resulting from the combination of fatty acids and alcohols. When the alcohol component is glycerol, the resulting fatty acid esters can be monoglycerides, diglycerides, or triglycerides. Fatty acid esters have an emollient conditioning effect, creating a smooth feel. Fatty acid esters can also be added to cosmetics to dissolve highly polar active ingredients and UV absorbers. Esters of straight-chain fatty acids and lower alcohols are effective in dissolving slightly soluble ingredients in oil with a light touch during application. Isostearic acid and other liquid oils, along with branched and unsaturated fatty acids, are commonly used in emollients. Higher fatty acid esters and esters of higher alcohols with relatively high melting points are added to skin creams to adjust the feel of application.

[0280] In a preferred variant, the fatty acid ester as oil component of the cosmetic or pharmaceutical composition of the invention is selected from the group consisting of C12-C15 alkyl benzoates, capric / lauric / myristic / oleic triglycerides, caprylic / capric triglycerides, caprylic / capric / lauric triglycerides, caprylic / capric / linoleic triglycerides, caprylic / capric / myristic / stearic triglycerides, caprylic / capric / palmitic / stearic triglycerides Caprylic / Capric / Stearic Triglyceride, Caprylic / Capric / Succinic Triglyceride, Caprylyl Caprylate, Cetearyl Ethylhexanoate, Cetearyl Isononanoate, Cetearyl Nonanoate, Coco-Caprylate, Decyl Cocoate, Decyl Oleate, Dicaprylyl Carbonate, Diethyl Succinate, Diethylhexyl Naphthalenedicarboxylate, Diethylhexyl Carbonate, Dibutyl Adipate, Diisopropyl Adipate, Dipropylheptyl Carbonate, Ethyl Laurate, Ethylhexyl Isononanoate, Palmitic Acid, Ethylhexyl tincture, Ethylhexyl stearate, Caprylic / Capric Glyceride, Glyceryl Caprylate, Glyceryl Laurate, Glyceryl Triacetylhydroxystearate, Glyceryl Triacetylricinoleate, Hexyl Laurate, Isoamyl Acetate, Isoamyl Cocoate, Isopropyl Palmitate, Isosorbide Dicaprylate, Isopropyl Myristate, Myristyl Myristate, Tri(Oleic / Linoleic)glyceride, Tri(Oleic / Palmitic)glyceride, Tri(Oleic / Palmitic) Lauric / Myristic / Linoleic Acid Glycerides, Caprylic Propanediol, Ricinoleic / Caproic / Caprylic / Tricapric Acid Glycerides, Oleostearin, Oleyl Erucate, Palmitic / Stearic Acid Glycerides, Dicaprylic / Capric Acid Propanediol, Propylheptyl Caprylate, Stearyl Heptanoate / Stearyl Caprylate, Triheptanoin, Trihydroxystearin, Triisononanoin, Triisopalmitin, Triisostearin, Trilaurin, Trilinolein, Trilinolenin,Trimyristin, triolein, tripalmitin, tripalmitolein, tripelargonin, triricinolein, and tristearin.

[0281] In certain preferred variants, the oil component of the cosmetic or pharmaceutical composition of the present invention is selected from the group consisting of C12-C15 alkyl benzoate, caprylic / capric triglyceride, caprylyl caprylate, cetearyl ethylhexanoate, cetearyl isononanoate, cetearyl nonanoate, coco-caprylate, decyl cocoate, decyl oleate, dicaprylyl carbonate, diethylhexyl 2,6-naphthalenedicarboxylate, dibutyl adipate, diisopropyl adipate, ethyl laurate, ethylhexyl isononanoate, ethylhexyl palmitate, ethyl stearate, ethyl hydroxybenzoate ... and fatty acid esters selected from the group consisting of ethylhexyl, glyceryl caprylate, glyceryl laurate, hexyl laurate, isoamyl cocoate, isopropyl palmitate, isopropyl myristate, myristyl myristate, caprylic / propanediol, oleyl erucate, tri(palmitic / stearic)glyceride, di(caprylic / capric)propanediol, trihydroxystearin, triisostearin, triisononanoin, tristearin, and mixtures of two or more of the foregoing fatty acid esters.

[0282] The fatty acid ester can be used as a single component or in a mixture with one or more further different fatty acid esters as specified above.

[0283] UV filters are compounds or mixtures that block or absorb ultraviolet (UV) light. Because excessive UV radiation can cause sunburn, photoaging, and skin cancer, skin care products, such as sunscreens, usually contain classifications that filter specific wavelengths. UV classifications include UVA (320-400 nm), UVB (290-320 nm), and UVC (200-280 nm). UV-absorbing compounds are used not only in sunscreens but also in other personal care products, such as lipstick, shampoo, hairspray, body wash, toilet soap, and insect repellents. Chemical filters block UV radiation by absorption, reflection, or scattering. Reflection and scattering are achieved by inorganic physical UV filters, such as titanium dioxide (TiO2) and zinc oxide (ZnO). Absorption, primarily of UVB, is achieved by organic UV filters, known as chemical UV filters.

[0284] In a preferred variant, the liquid UV filters as oil constituents of the cosmetic or pharmaceutical compositions according to the invention are selected from the group consisting of octocrylene, ethylhexyl salicylate, homosalate, ethylhexyl methoxycinnamate, isoamyl p-methoxycinnamate, camphor benzalkonium methosulfate, polyarylamidomethyl benzylidene camphor, isooctyl methoxycinnamate, ethylhexyl triazone, drometrizole trisiloxane, diethylhexyl butamido triazone, 3-benzylidene camphor, octyl salicylate, ethylhexyl dimethyl PABA, bis-ethylhexyloxyphenol methoxyphenyl triazine, polysilicone-15, diethylamino hydroxybenzoyl hexyl benzoate, N,N,N- trimethyl-4-(2-oxoborn-3-ylidenemethyl)anilinium methyl sulfate, benzoic acid-2-hydroxy-3,3,5-trimethylcyclohexyl ester / homosalate, 2-cyano-3,3-diphenylacrylic acid, 2-ethylhexyl ester / octocrylene, 2-ethylhexyl-4-methoxycinnamate / octinoxate, ethoxylated ethyl-4-aminobenzoic acid, 2-ethylhexyl salicylate / octisalate, 2-ethylhexyl-4-(dimethylamino)benzoate / padimate O (USAN:BAN), 2,2'-methylene-bis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethyl-butyl)phenol) / bisoctrizole, and dimethicodiethyl benzalmalonate.

[0285] In certain preferred variants, the oil component of the cosmetic or pharmaceutical composition of the present invention is selected from the group consisting of octocrylene, ethylhexyl salicylate, homosalate, ethylhexyl methoxycinnamate, isoamyl p-methoxycinnamate, N,N,N-trimethyl-4-(2-oxoborn-3-ylidenemethyl)anilinium methyl sulfate, benzoic acid-2-hydroxy-3,3,5-trimethylcyclohexyl ester / homosalate, 2-cyano-3,3-diphenylacrylic acid, 2-ethylhexyl ester / octocrylene, 2-ethylhexyl-4-methoxycinnamate. liquid UV filters selected from the group consisting of namate / octinoxate, ethoxylated ethyl-4-aminobenzoate, 2-ethylhexyl salicylate / octisalate, 2-ethylhexyl-4-(dimethylamino)benzoate / padimate O(USAN:BAN), 2,2'-methylene-bis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethyl-butyl)phenol) / bisoctrizole, dimethicodiethyl benzalmalonate, and mixtures of two or more of the foregoing UV filters.

[0286] The UV filters can be used as single components or in mixtures with one or more further different UV filters as specified above.

[0287] In addition to the oil component(s) as previously defined, the cosmetic or pharmaceutical composition according to the invention preferably comprises one or more further oil bodies. Suitable oil bodies are those which form constituents of O / W emulsions, such as Guerbet alcohols, which are based on fatty alcohols having 6 to 18, preferably 8 to 10, carbon atoms, esters of linear C5 to C22 fatty acids with linear or branched C5 to C22 fatty alcohols, or esters of branched C1 to C13 carboxylic acids with linear or branched C6 to C22 fatty alcohols, such as myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl erucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetyl isostearate, cetyl oleate, cetyl behenate, cetyl erucate, stearyl myristate, stearyl palmitate, stearyl stearate, isostearate, Stearyl phosphate, stearyl oleate, stearyl behenate, stearyl erucate, isostearyl myristate, isostearyl palmitate, isostearyl stearate, isostearyl isostearate, isostearyl oleate, isostearyl behenate, isostearyl oleate, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleyl erucate, behenyl myristate, behenyl palmitate, behenyl stearate, behenyl isostearate, behenyl oleate, behenyl behenate, behenyl erucate, erucyl myristate, erucyl palmitate, erucyl stearate, erucyl isostearate, erucyl oleate, erucyl behenate, and erucyl erucate.Esters of linear C6 to C22 fatty acids with branched alcohols, in particular 2-ethylhexanol, esters of C18 to C38 alkylhydroxycarboxylic acids with linear or branched C6 to C22 fatty alcohols, in particular dioctyl malate, esters of linear and / or branched fatty acids with polyhydric alcohols (e.g. propylene glycol, dimerdiol or trimertriol) and / or Guerbet alcohols, triglycerides based on C6 to C10 fatty acids, liquid mono- / di- / triglyceride mixtures based on C6 to C18 fatty acids, C6 to C22 fatty alcohols and / or Guerbet alcohols Esters of alcohols with aromatic carboxylic acids, in particular benzoic acid, esters of C2-C12 dicarboxylic acids with linear or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, linear or branched CC-C22 fatty alcohol carbonates, for example dicaprylyl carbonate (Cetiol® CC), carbonate guerbet based on fatty alcohols having 6 to 18, preferably 8 to 10, carbon atoms, benzoic acid with linear and / or branched C6-C 22 Also suitable are esters with alcohols (e.g. Finsolv® TN), linear or branched, symmetrical or asymmetrical dialkyl ethers having 6 to 22 carbon atoms per alkyl group, such as dicaprylyl ether (Cetiol® OE), ring-opening products of epoxidized fatty acid esters with polyols, silicone oils (cyclomethicone, silicone methicone grades, etc.), and / or aliphatic or naphthenic hydrocarbons, such as squalane, squalene or dialkylcyclohexanes.

[0288] Within the context of the present invention, it is also possible, and in some cases advantageous, to combine the cosmetic or pharmaceutical composition, in particular the dermatological composition according to the first or second aspect of the invention, with other active substances, adjuvants, additives or auxiliaries different from the antimicrobial component (b) of the cosmetic or pharmaceutical composition according to the invention, and with further active agents which may be incorporated into the cosmetic or pharmaceutical composition, as well as with those already described above, for example sebum-reducing agents, anti-acne agents, anti-dandruff agents, anti-inflammatory and / or redness and / or itching-relieving agents, odor-absorbing and / or antiperspirant active agents, emollients, moisturizing and / or moisture-retaining substances, physiological cooling agents or Tetraselmis suecica extracts, as previously described.

[0289] Thus, optionally, other conventional cosmetic and / or pharmaceutical active substances, adjuvants, additives or auxiliaries, as further described below, can also be added as component (c), i.e. to obtain a composition or formulation that is ready for use.

[0290] The cosmetic or pharmaceutical compositions according to the invention may further comprise other cosmetic and / or pharmaceutical active substances, adjuvants, additives or auxiliaries, such as, for example, abrasives, skin anti-aging agents, anti-cellulitis agents, antioxidants, astringents, odor absorbers, antiperspirants, antistatic agents, binders, buffers, carrier materials, chelating agents, cell stimulants, depilatories, surfactants, deodorants, antiperspirants, softeners, emulsifiers, enzymes, enzyme inhibitors, essential oils, as described further below. yl, fibres, film formers, fixatives, foam formers, foam stabilizers, defoaming substances, foam boosters, gelling agents, gel forming agents, hair care agents, hair setting agents, hair straighteners, bleaching agents, strengthening agents, stain removers, optical brighteners, injecting agents, stain repellents, dyes, antifriction agents, lubricants, opacifying agents, plasticisers, coatings, polishing agents, preservatives, glossing agents, green and synthetic polymers, powders, proteins, re-oiling agents, abrasive agents, silicones, skin emollients, skin care agents, skin healing agents, skin whitening agents, They may be advantageously combined with skin protectants, emollients, hair growth promoters, warming agents, skin warming agents, stabilizers, surfactants, UV absorbers, UV filters, primary sun protection factors, secondary sun protection factors, detergents, fabric softeners, suspending agents, tanning agents, active skin conditioners or hair pigmentation agents, matrix metalloproteinase inhibitors, glycosaminoglycan stimulators, TRPV1 antagonists, desquamating agents, anti-cellulite or fat-enhancing agents, hair growth activators or inhibitors, thickeners, rheological additives, vitamins, oils, waxes, pearlescent waxes, fats, phospholipids, saturated fatty acids, mono- or polyunsaturated fatty acids, alpha-hydroxy acids, polyhydroxy fatty acids, liquefying agents, dyes, color protection agents, pigments, corrosion inhibitors, fragrances or perfume oils, aromas, flavoring substances, odorous substances, polyols, electrolytes, organic solvents and the like, as well as mixtures of two or more of the above-mentioned substances, which are commonly used in such compositions.

[0291] The above-mentioned cosmetic and / or pharmaceutical active substances, adjuvants, additives or auxiliaries anti-aging agents, antioxidants, chelating agents, emulsifiers, surfactants, preservatives, green and synthetic polymers, rheological additives, oils, fragrances or perfume oils, polyols, and mixtures of two or more of the above-mentioned agents are particularly preferred for the preparation of cosmetic and pharmaceutical compositions.

[0292] Anti-aging actives: The cosmetic or pharmaceutical compositions according to the invention preferably contain one or more anti-aging actives. In the context of the present invention, anti-aging or biogenic agents are, for example, antioxidants, matrix metalloproteinase inhibitors (MMPIs), skin moisturizers, glycosaminoglycan stimulators, anti-inflammatory agents, TRPV1 antagonists and plant extracts.

[0293] Antioxidants: Preferred cosmetic or pharmaceutical compositions according to the present invention comprise one or more antioxidants. Suitable antioxidants include amino acids (preferably glycine, histidine, tyrosine, tryptophan) and derivatives thereof, imidazole (preferably urocanic acid) and derivatives thereof, peptides, preferably D,L-carnosine, D-carnosine, L-carnosine and derivatives thereof (preferably anserine), carnitine, creatine, matrikine peptides (preferably lysyl-threonyl-threonyl-lysyl-serine) and palmitoylated pentapeptides, carotenoids, carotenes (preferably alpha-carotene, beta-carotene, lycopene) and derivatives thereof, lipoic acid and derivatives thereof (preferably dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (preferably thioredoxin, glutathione, cysteine, cystine, cystamine and glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, gamma-linoleyl, cholesteryl, glyceryl and its oligoglyceryl esters) and salts thereof, dilauryl thiodipropionate, thio Distearyl dipropionate, thiodipropionic acid and derivatives thereof (preferably esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (preferably buthionine sulfoximine, homocysteine ​​sulfoximine, buthionine sulfone, penta-, hexa-, heptathionine sulfoximine) in very small tolerated doses (e.g. pmol-μmol / kg), as well as (metal) chelating agents (preferably alpha-hydroxy fatty acids, palmitic acid, phytic acid, lactate). Feline, alpha-hydroxy acids (preferably citric acid, lactic acid, malic acid), humic acid, bile acids, bile extract, tannins, bilirubin, biliverdin, EDTA, EGTA and derivatives thereof, unsaturated fatty acids and derivatives thereof (preferably gamma-linolenic acid, linoleic acid, oleic acid), folic acid and derivatives thereof, ubiquinone and derivatives thereof, ubiquinol and derivatives thereof, vitamin C and derivatives (preferably ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl acetate, ascorbyl glucoside),Tocopherols and derivatives (preferably vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and coniferyl benzoate of benzoic acid resin, rutinic acid and derivatives, flavonoids and their glycosylated precursors, in particular quercetin and its derivatives, preferably alpha-glucosylrutin, rosmarinic acid, carnosol, carnosic acid, resveratrol, caffeic acid and derivatives, sinapic acid and derivatives, ferulic acid and derivatives, curcuminoids, chlorogenic acid and derivatives, retinoids, preferably retinyl palmitate, retinol or tretinoin, ursolic acid, levulinic acid and its esters and / or ketals, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiacic acid, nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and derivatives, mannose and derivatives conductors, zinc and its derivatives (preferably ZnO, ZnSO), selenium and its derivatives (preferably selenomethionine), superoxide dismutase, stilbene and its derivatives (preferably stilbene oxide, trans-stilbene oxide) and derivatives of these cited active ingredients (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) that are suitable according to the invention or extracts or fractions of plants with antioxidant action, preferably green tea, rooibos, honeybush, grape, rosemary, sage, melissa, thyme, lavender, olive, oat, cocoa, ginkgo, ginseng, licorice, honeysuckle, pagoda tree, kudzu, pinus, citrus, emulsifier or St. John's wort, grape seed, wheat germ, emulsifier, coenzymes, preferably coenzyme Q10, plastoquinone and menaquinone. Preferred antioxidants are selected from the group consisting of vitamin A and derivatives, vitamin C and derivatives, tocopherol and derivatives, preferably tocopherol acetate, and ubiquinone. When vitamin E and / or its derivatives are used as antioxidant(s), their concentrations are based on the total weight of the composition.It is advantageous to choose from the range of about 0.001 to about 10% by weight. When vitamin A or a vitamin A derivative or carotene or its derivatives are used as antioxidant(s), it is advantageous to choose their concentration from the range of about 0.001 to about 10% by weight, based on the total weight of the composition.

[0294] Matrix Metalloproteinase Inhibitors (MMPIs): Preferred cosmetic or pharmaceutical compositions according to the invention comprise one or more matrix metalloproteinase inhibitors, in particular those that inhibit matrix metalloproteinases that enzymatically cleave collagen, such as ursolic acid, retinyl palmitate, propyl gallate, precocene, 6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran, 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran, benzamidine hydrochloride, the cysteine ​​protease inhibitor N-ethylmaleimide and the serine protease inhibitor epsilon-amino-n-caproic acid; phenylmethylsulfonyl fluoride, colhibin (Pentapharm; INCI: Hydrolyzed Rice Protein), oenocerol (Soliance; INCI: Propylene Glycol, Tap Water, Oenothera biennis root extract, ellagic acid and ellagitannins, e.g., from pomegranate), phosphoramidon hinokitiol, EDTA, galardin, EquiStat (Collaborative Group; apple fruit extract, soybean seed extract, ursolic acid, soy isoflavones, and soy protein), sage extract, MDI (Atrium; INCI: glycosaminoglycans), fermiskin (Silab / Mawi; INCI: water and lentinus edodes extract), actimp1.9.3 (Expanscience / Rahn; INCI: hydrolyzed lupin proteins), Lipobelle soy glycones (Mibelle; INCI: alcohol, polysorbate 80, lecithin and soy isoflavones), extracts from green tea and black tea, further plant extracts, proteins or glycoproteins from soybeans, hydrolyzed proteins from rice, pea or lupin, plant extracts that inhibit MMPs, preferably extracts from shiitake mushrooms, extracts from leaves of the family Rosaceae, extracts of the subfamily Rosoideae, in particular blackberry leaf extracts, such as SymMatrix (Symrise, INCI: maltodextrin, Rubus Fruticosus (blackberry) leaf extract).Preferred active substances are selected from the group consisting of retinyl palmitate, ursolic acid, extract from the leaves of the family Rosaceae, subfamily Rosoideae, genistein and daidzein.

[0295] Glycosaminoglycan stimulators: Preferred cosmetic or pharmaceutical compositions according to the invention include hyaluronic acid and derivatives or salts, Subliskin (Sederma, INCI: Sinorhizobium meliloti fungal ferment filtrate, cetyl hydroxyethylcellulose, lecithin), Hyalufix (BASF, INCI: water, butylene glycol, Alpinia galanga leaf extract, xanthan gum, caprylic / capric triglyceride), Stimulhyal (Soliance, INCI: calcium ketogluconate), Syn-Glycan (DSM, INCI: tetradecylaminobutyroylvalylaminobutylurea trifluoroacetic acid, glycerin, magnesium chloride), Kalpariane (BiotechMarine), DCUPregulex (special cosmetic ingredient, INCI: water, butylene glycol, phospholipids, hydrolyzed sericin), glucosamine, N-acetylglucosamine, retinoids, preferably retinol and vitamin A, Arctium The composition contains one or more substances that stimulate the synthesis of glycosaminoglycans selected from the group consisting of Burdock fruit extract, Eriobotrya japonica extract, Genkwanin, N-methyl-L-serine, (-)-alpha-bisabolol or synthetic alpha-bisabolol, such as Dragosantol and Dragosantol 100, manufactured by Symrise, oat glucan, Echinacea purpurea extract and soy protein hydrolysate. Preferred active substances are selected from the group consisting of hyaluronic acid and derivatives or salts, retinol and derivatives, (-)-alpha-bisabolol or synthetic alpha-bisabolol such as Dragosantol and Dragosantol 100, Symrise, oat glucan, Echinacea purpurea extract, Sinorhizobium meliloti (alfalfa) ferment broth, calcium ketogluconate, Alpinia galanga (Salt Tree) leaf extract and tetradecylaminobutyroylvalylaminobutylurea trifluoroacetate.

[0296] TRPV1 Antagonists: Preferred cosmetic or pharmaceutical compositions according to the present invention comprise one or more TRPV1 antagonists. Suitable compounds that act as TRPV1 antagonists and reduce the hypersensitivity of skin nerves include, for example, trans-4-tert-butylcyclohexanol, or preferably indirect modulators of TRPV1 via activation of the μ receptor, such as acetyltetrapeptide-15.

[0297] Plant extracts: Preferred cosmetic or pharmaceutical compositions according to the present invention contain one or more plant extracts. Plant extracts, special highly active plant extract fractions, and even highly pure active substances isolated from plant extracts can also be used in cosmetic or pharmaceutical compositions according to the present invention. Extracts, fractions, and active substances from chamomile, aloe vera, Commiphora species, Rubia species, willow, willow herb, ginger, marigold, arnica, Glycyrrhiza species, Echinacea species, and Rubus species, as well as pure substances, such as bisabolol, apigenin, apigenin-7-glucoside, gingerols, such as [6]-gingerol, paradols, such as [6]-paradol, boswellic acid, phytosterols, glycyrrhizin, glabridin, and licochalcone A, are particularly preferred.

[0298] Desquamating agents: The cosmetic or pharmaceutical compositions according to the invention preferably contain one or more desquamating agents. The expression "desquamating agent" is understood to mean any compound capable of: any compound capable of acting directly on desquamation by promoting peeling, such as beta-hydroxy acids, in particular salicylic acid and its derivatives (including 5-n-octanoylsalicylic acid); alpha-hydroxy acids, such as glycolic acid, citric acid, lactic acid, tartaric acid, malic acid or mandelic acid; urea; gentisic acid; oligofucose; cinnamic acid; extracts of Sophora japonica (Japanese pagoda tree); some derivatives of resveratrol and jasmonic acid; - or any compound capable of acting on enzymes involved in desquamation or degradation of corneodesmosomes, glycosidases, stratum corneum chymotryptic enzymes (SCCE) or other proteases (trypsin, chymotrypsin-like). Chelating inorganic salts: EDTA; N-acyl-N,N',N'-ethylenediaminetriacetic acid; aminosulfonic acid compounds and in particular (N-2-hydroxyethylpiperazine-N-2-ethane)sulfonic acid (HEPES); derivatives of 2-oxothiazolidine-4-carboxylic acid (procysteine); glycine-type derivatives of alpha-amino acids (as described in EP-0852949, sodium methylglycine diacetate, from BASF under the trade name TRILON honey; sugar derivatives, such as O-octanoyl-6-D-maltose and N-acetylglucosamine; chestnut extract, such as that sold by the company SILAB under the name Recoverine®, prickly pear extract, such as that sold by the company SILAB under the name Exfolactive®, or phytosphingosine SLC® (phytosphingosine grafted with salicylic acid) sold by the company Degussa.

[0299] Desquamating agents suitable for the present invention may be selected from the group comprising, in particular, sulfonic acids, calcium chelating agents, alpha-hydroxy acids, such as glycolic acid, citric acid, lactic acid, tartaric acid, malic acid or mandelic acid; ascorbic acid and its derivatives, such as ascorbyl glucoside and magnesium ascorbyl phosphate; nicotinamide; urea; (N-2-hydroxyethylpiperazine-N-2-ethane)sulfonic acid (HEPES), beta-hydroxy acids, such as salicylic acid and its derivatives, retinoids, such as retinol and its esters, retinal, retinoic acid and its derivatives, chestnut or prickly pear extracts, in particular those marketed by SILAB; reducing compounds, such as cysteine ​​or cysteine ​​precursors.

[0300] Desquamating agents that can be used are also nicotinic acid and its esters and nicotinamide, also called vitamin B3 or vitamin PP, and ascorbic acid and its precursors.

[0301] (Metal) chelating agents: A combination of one or more (metal) chelating agents can also be advantageously used in the cosmetic or pharmaceutical compositions according to the present invention, and any metal chelating agent suitable or conventional for cosmetic or pharmaceutical applications can be used. Preferred (metal) chelating agents include α-hydroxy fatty acids, phytic acid, lactoferrin, α-hydroxy acids, such as gluconic acid, glyceric acid, glycolic acid, isocitric acid, citric acid, lactic acid, malic acid, mandelic acid, tartaric acid, and humic acid, bile acids, bile extracts, bilirubin, biliverdin, or EDTA, EGTA, and derivatives thereof. The use of one or more chelating agents improves the stability of the compositions according to the present invention.

[0302] Emulsifiers: In addition, the cosmetic or pharmaceutical composition according to the invention may also advantageously contain one or more emulsifiers, including, for example: - linear C of 2 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide 8~22 Addition products to aliphatic alcohols, C 12~22 Addition products onto fatty acids and onto alkylphenols containing 8 to 15 carbon atoms in the alkyl group; - C of the addition products of 1 to 30 moles of ethylene oxide to glycerol 12 / 18 fatty acid monoesters and diesters, - glycerol mono- and diesters and sorbitan mono- and diesters of saturated and unsaturated fatty acids containing 6 to 22 carbon atoms and their ethylene oxide addition products, - addition products of 15 to 60 moles of ethylene oxide onto castor oil and / or hydrogenated castor oil, polyol esters, in particular polyglycerol esters, such as polyglycerol polyricinoleate, polyglycerol poly-12-hydroxystearate or polyglycerol dimer isostearate. Mixtures of compounds from several of these classes are also suitable. - addition products of 2 to 15 moles of ethylene oxide onto castor oil and / or hydrogenated castor oil, - Linear, branched, unsaturated or saturated C 6 / 22 partial esters based on fatty acids, ricinoleic acid and 12-hydroxystearic acid with glycerol, polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols (e.g. sorbitol), alkyl glucosides (e.g. methyl glucoside, butyl glucoside, lauryl glucoside) and polyglucosides (e.g. cell...

Claims

1. (a1) 1,2-nonanediol, (b1) at least one antimicrobial component, and (c2) optionally at least one cosmetic or pharmaceutical active substance and / or additives, A cosmetic or pharmaceutical composition comprising or consisting of: the at least one antimicrobial component (b1) is selected from the group consisting of phenoxyethanol, farnesol, ethylhexylglycerin, triethyl citrate, hydroxyacetophenone, benzyl alcohol, 2-methyl-5-cyclohexylpentanol, benzoic acid, sorbic acid, dehydroacetic acid, sorbitan caprylate, caprylhydroxamic acid, dimethylphenylbutanol, dimethylphenylpropanol, levulinic acid and its esters and / or ketals, anisic acid, 2-benzylheptanol, polyglyceryl caprylate -3, Polyglyceryl-10 Laurate, Glyceryl Caprate, Polyglyceryl-2 Caprate, Zinc Ricinoleate, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Salvia Officinalis (Sage) Oil, Tropolone, Piroctone Olamine, Triclosan, Triclocarban, Chloroxylenol, Chlorocresol, Benzalkonium Chloride, Benzalkonium Bromide, Benzalkonium Saccharinate, Benzethonium Chloride, Chlorphenesin, Alkyl (C12-22) Trimethylammonium Bromide and Chloride, Zinc Pyrithione, Climbazole, Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, Chlorhexidine Dihydrochloride, Hexamidine, Hexamidine Diisethionate, Silver Chloride, Silver Citrate, Hexylglycerin, Cyclopentasiloxane, Glycerin, Tetraselmis Suesica (Tetraselmis)suecica extract, mannitol, sorbitol, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, zinc citrate, cetylpyridinium chloride, menthol, eucalyptol, methyl salicylate, ethanol, camphor, polyarginine, polylysine, gluconic acid and its salts, ascorbic acid and its salts, benzyl salicylate, disodium EDTA, methylparaben, and and its salts, sodium benzoate, potassium sorbate, propylparaben, methylchloroisothiazolinone, methylisothiazolinone, butylparaben, ethylparaben, propylparaben sodium, DMDM ​​hydantoin, hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, itaconic acid and its salts, propanediol caprylate, 4-hydroxyacetophenone, iodopropynyl butylcarbamate, isobutylparaben, ethylparaben sodium, diazolidinyl urea, caprylic acid Lyceryl, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketals, TEA salicylate, phenethyl alcohol, tetrasodium glutamate diacetate, trisodium ethylenediaminedisuccinate, sodium lactate, 4-hydroxybenzoic acid and its salts and esters, thyme oil, eugenol, clove oil, mint oil, DMC, antibacterial fragrance, frangipanione, xylityl caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Decanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-nonanediol, and a cosmetic or pharmaceutical composition selected from the group consisting of 2-hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components.

2. (a2) 1,2-heptanediol, (b2) at least one antimicrobial component, and (c2) optionally at least one cosmetic or pharmaceutical active substance and / or additive; A cosmetic or pharmaceutical composition comprising or consisting of: The at least one antimicrobial component (b2) is selected from the group consisting of phenoxyethanol, farnesol, bisabolol, ethylhexylglycerin, triethyl citrate, hydroxyacetophenone, benzyl alcohol, 2-methyl-5-cyclohexylpentanol, benzoic acid, sorbic acid, dehydroacetic acid, sorbitan caprylate, caprylhydroxamic acid, dimethylphenylbutanol, dimethylphenylpropanol, levulinic acid and its esters and / or ketals, anisic acid, 2-benzylheptanol, polyglyceryl caprylate, hydroxybenzoates ... Lyceryl-3, Polyglyceryl-10 Laurate, Glyceryl Caprate, Polyglyceryl-2 Caprate, Zinc Ricinoleate, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Salvia officinalis) Officinalis (Sage) Oil, Tropolone, Piroctone Olamine, Triclosan, Triclocarban, Chloroxylenol, Chlorocresol, Benzalkonium Chloride, Benzalkonium Bromide, Benzalkonium Saccharinate, Benzethonium Chloride, Chlorphenesin, Alkyl (C12-22) Trimethylammonium Bromide and Chloride, Zinc Pyrithione, Climbazole, Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, Chlorhexidine Dihydrochloride, Hexamidine, Hexamidine Diisethionate, Silver Chloride, Silver Citrate, Hexylglycerin, Cyclopentasiloxane, Glycerin, Tetraselmis Suesica (Tetraselmis)suecica extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, zinc citrate, cetylpyridinium chloride, menthol, eucalyptol, methyl salicylate, ethanol, camphor, polyarginine, polylysine, gluconic acid and its salts, ascorbic acid and its salts, benzyl salicylate, disodium EDTA, methylparaben and its salts, sodium benzoate, potassium sorbate, propylparaben, methylchloroisothiazolinone, methylisothiazolinone, butylparaben, ethylparaben, propylparaben sodium, DMDM ​​hydantoin, hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, itaconic acid and its salts, propanediol caprylate, 4-hydroxyacetophenone, iodopropynyl butylcarbamate, isobutylparaben, ethylparaben sodium, diazolidinyl urea, caprylic Glyceryl stearate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketals, TEA salicylate, phenethyl alcohol, tetrasodium glutamate diacetate, trisodium ethylenediaminedisuccinate, sodium lactate, 4-hydroxybenzoic acid and its salts and esters, thyme oil, eugenol, clove oil, mint oil, DMC, antibacterial fragrance, frangipane, xylityl caprylate, 3-hydroxypropyl benzoate, 3-hydroxy anisate propyl esters, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components.

3. (a) at least one linear alkanediol having a carbon chain of 5 to 14 carbon atoms, or a mixture comprising at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms and one or more second linear alkanediols different from the first linear alkanediol having a carbon chain of 5 to 14 carbon atoms; (b) at least one antimicrobial component, and (c) optionally at least one cosmetic or pharmaceutical active substance and / or additive; 1. A cosmetic or pharmaceutical composition comprising or consisting of a mixture comprising at least one first linear alkanediol and one or more second linear alkanediols, a mixture comprising 1,2-hexanediol and 2,3-hexanediol; a mixture comprising 1,2-heptanediol and 2,3-heptanediol; a mixture comprising 1,2-octanediol and 2,3-octanediol; a mixture comprising 1,2-nonanediol and 2,3-nonanediol; a mixture comprising 1,2-decanediol and 2,3-decanediol; a mixture comprising 1,2-undecanediol and 2,3-undecanediol; a mixture comprising 1,2-dodecanediol and 2,3-dodecanediol, and Mixture containing 1,2-tridecanediol and 2,3-tridecanediol or is selected from the group consisting of a mixture comprising 1,2-hexanediol and 2,3-octanediol; a mixture comprising 1,2-octanediol and 2,3-hexanediol, and A mixture containing 1,2-octanediol and 2,3-heptanediol or is selected from the group consisting of a mixture comprising 1,2-pentanediol and 2,3-hexanediol; a mixture comprising 1,2-pentanediol and 1,2-heptanediol; a mixture comprising 1,2-pentanediol and 2,3-heptanediol; a mixture comprising 1,2-pentanediol and 2,3-octanediol; a mixture comprising 1,2-pentanediol and 1,2-nonanediol, and a mixture comprising 1,2-pentanediol and 2,3-nonanediol; or is selected from the group consisting of a mixture comprising 1,2-heptanediol and 1,2-octanediol; a mixture comprising 1,2-heptanediol and 2,3-octanediol; a mixture comprising 1,2-heptanediol and 1,2-nonanediol, and A mixture containing 1,2-heptanediol and 2,3-nonanediol or wherein the linear alkanediol is selected from the group consisting of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, 2,3-tridecanediol, and mixtures thereof.

4. A cosmetic or pharmaceutical composition according to any one of claims 1 to 3, wherein the mixture comprising at least one first linear alkanediol and one or more second linear alkanediols comprises the first linear alkanediol and the second alkanediol(s) in a ratio ranging from 50:50 to 99.9:0.

1.

5. The at least one antimicrobial component (b) is selected from the group consisting of phenoxyethanol, farnesol, bisabolol, ethylhexylglycerin, triethyl citrate, hydroxyacetophenone, benzyl alcohol, 2-methyl-5-cyclohexylpentanol, benzoic acid, sorbic acid, dehydroacetic acid, sorbitan caprylate, caprylhydroxamic acid, dimethylphenylbutanol, dimethylphenylpropanol, levulinic acid and its esters and / or ketals, anisic acid, 2-benzylheptanol, polyglyceryl caprylate, and the like. Ceryl-3, Polyglyceryl-10 Laurate, Glyceryl Caprate, Polyglyceryl-2 Caprate, Zinc Ricinoleate, Glyceryl Laurate, Glyceryl Caprylate, Xylityl Sesquicaprylate, Phenylpropanol, Lauryl Alcohol, o-Cymen-5-ol, Octenidine HCl, Undecylenoyl Glycine, Sodium Caproyl Lactylate / Sodium Lauroyl Lactylate, Lauroyl Arginate Ethyl Laurate, Cocoyl Arginate Ethyl PCA, Salvia Officinalis (Salvia officinalis) Officinalis (Sage) Oil, Tropolone, Piroctone Olamine, Triclosan, Triclocarban, Chloroxylenol, Chlorocresol, Benzalkonium Chloride, Benzalkonium Bromide, Benzalkonium Saccharinate, Benzethonium Chloride, Chlorphenesin, Alkyl (C12-22) Trimethylammonium Bromide and Chloride, Zinc Pyrithione, Climbazole, Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, Chlorhexidine Dihydrochloride, Hexamidine, Hexamidine Diisethionate, Silver Chloride, Silver Citrate, Hexylglycerin, Cyclopentasiloxane, Glycerin, Tetraselmis Suesica (Tetraselmis)suecica extract, mannitol, sorbitol, lactic acid, sodium lauroyl lactylate, sodium caproyl lactylate, salicylic acid and its salts, capryloyl glycine, ethyl lauroyl arginate HCl, thymol, jasmol, zinc citrate, cetylpyridinium chloride, menthol, eucalyptol, methyl salicylate, ethanol, camphor, polyarginine, polylysine, gluconic acid and its salts, ascorbic acid and its salts, benzyl salicylate, disodium EDTA, methylparaben and its salts Salt, sodium benzoate, potassium sorbate, propylparaben, methylchloroisothiazolinone, methylisothiazolinone, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, itaconic acid and its salts, propanediol caprylate, 4-hydroxyacetophenone, iodopropynyl butylcarbamate, isobutylparaben, sodium ethylparaben, diazolidinyl urea, glyceryl caprylate, phytin Sodium levulinate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketals, TEA salicylate, phenethyl alcohol, tetrasodium glutamate diacetate, trisodium ethylenediaminedisuccinate, sodium lactate, 4-hydroxybenzoic acid and its salts and esters, thyme oil, eugenol, clove oil, mint oil, DMC, antibacterial fragrance, flavinone, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-hydroxybenzoic acid 4. The cosmetic or pharmaceutical composition of claim 3, wherein the antimicrobial component is selected from the group consisting of propyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the foregoing antimicrobial components.

6. 6. The cosmetic or pharmaceutical composition according to claim 1, wherein the at least one cosmetic or pharmaceutical active substance and / or additive is selected from the group consisting of skin anti-aging agents, antioxidants, chelating agents, emulsifiers, surfactants, antimicrobial agents for product protection, green and synthetic polymers, rheological additives, oils, fragrances or perfume oils, polyols, and mixtures of two or more of the aforementioned substances.

7. 7. The cosmetic or pharmaceutical composition of claim 1, further comprising a sebum-reducing agent, an anti-acne agent, an anti-dandruff agent, an anti-inflammatory and / or redness and / or itching relieving agent, an odor absorbing and / or antiperspirant active substance, a emollient substance, a moisturizing and / or moisture-retaining substance, a physiological cooling agent, an extract of Tetraselmis suecica, or a mixture of two or more of the aforementioned agents or substances.

8. 1,2-nonanediol, or 1,2-heptanediol, or at least one linear alkanediol, or a mixture comprising at least one first linear alkanediol and one or more second linear alkanediols, in an amount of 0.001 to 15.0 wt. %, based on the total weight of the composition; and / or - comprising a 2,3-alkanediol as linear alkanediol or a mixture of 2,3-alkanediols comprising at least one first linear alkanediol and one or more second linear alkanediols in an amount of 0.001 to 15.0% by weight, relative to the total weight of the composition; and / or 8. The cosmetic or pharmaceutical composition according to any one of claims 1 to 7, comprising at least one antimicrobial component in an amount of 0.001 to 15.0% by weight, based on the total weight of the composition.

9. in the form of a dispersion comprising an oil component in an amount of ≥ 1% by weight in the form of an emulsion selected from the group consisting of O / W emulsions, W / O emulsions, multiple emulsions, dispersed hydrogels, balms, multiple emulsions of water-in-oil (W / O / W) or oil-in-water (O / W / O) type, Pitt emulsions, Pickering emulsions, microemulsions, as a liquid, lotion, suspension, in the form of a milk, ointment, paste, gel, cream-based, oil-based or liposome-based formulation, or - in the form of a liquid surfactant preparation, or - in the form of a solid surfactant preparation, or A cosmetic or pharmaceutical composition according to any one of claims 1 to 8, in the form of an aqueous or aqueous / alcoholic solution, aqueous / ethanolic or aqueous / glycolic acid-based solution containing alcohol or glycol in an amount of 0.1% to ≦50% by weight relative to the total weight of the solution.

10. For personal care, skin protection, skin care, scalp protection, scalp care, hair care, nail care, or for the prevention and / or treatment of skin conditions, intolerance or sensitive skin, skin irritation, skin redness, pruritus (itching), loss of skin volume, loss of skin elasticity, dry skin, peeling, stickiness, or for animal care, or 10. Use of 1,2-nonanediol, or 1,2-heptanediol, or at least one linear alkanediol or a mixture comprising at least one first linear alkanediol and one or more second linear alkanediols as defined in claim 3 or 4 for use in the prevention and / or treatment of dermatological or keratinous diseases, dermatological or keratinous diseases caused by microorganisms or associated with sebum excess or severe dandruff, selected from the group consisting of eczema, psoriasis, seborrhea, dermatitis, erythema, pruritus (itching), inflammation, irritation, fibrosis, lichen planus, pityriasis rosea, tinea versicolor, autoimmune bullous diseases, urticaria, angioedema, allergic skin reactions, wound healing and tissue regeneration, for the manufacture of a cosmetic or pharmaceutical composition according to any one of claims 1 to 9.

11. For use as a medicine, and 10. The cosmetic or pharmaceutical composition according to any one of claims 1 to 9 for use in the prevention and / or treatment of dermatological or keratinous disorders caused by microorganisms or associated with excessive sebum production or severe dandruff, selected from the group consisting of eczema, psoriasis, seborrhea, dermatitis, erythema, pruritus (itching), inflammation, irritation, fibrosis, lichen planus, pityriasis rosea, tinea versicolor, autoimmune bullous diseases, urticaria, angioedema, allergic skin reactions, wound healing and tissue regeneration.

12. Staphylococcus, Corynebacterium, Anaerococcus, Finegoldia, Moraxella, Porphyromonas, Fusobacterium, Aspergillus on the skin or scalp , Candida, Malassezia, Escherichia, Peptoniphilus, Streptococcus, Lactobacillus, Gardnerella, Fannyhesse, Epidermophyton, Use of 1,2-nonanediol, or 1,2-heptanediol, or at least one linear alkanediol, or a mixture comprising at least one first linear alkanediol and one or more second linear alkanediols as defined in claim 3 or 4, for the manufacture of a cosmetic or pharmaceutical composition according to any one of claims 1 to 9, for reducing or inhibiting the microbial activity of microorganisms selected from the group consisting of microorganisms of the genera Trichophyton, Cutibacterium, and combinations thereof; and / or for balancing sebum production on the skin or scalp or reducing excess sebum production; and / or for controlling dandruff on the skin, scalp, or nails; and / or as an antimicrobial component replacer in a cosmetic or pharmaceutical composition.

13. 13. The use according to claim 12, wherein the at least one linear alkanediol is selected from the group consisting of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, 2,3-tridecanediol, and mixtures thereof.

14. comprising a linear 1,2-alkanediol selected from the group consisting of 1,2-heptanediol, 1,2-nonanediol, 1,2-undecanediol, and 1,2-tridecanediol, or comprising a linear 2,3-alkanediol selected from the group consisting of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, and 2,3-tridecanediol, or a mixture comprising a linear 1,2-alkanediol and a linear 2,3-alkanediol selected from the group consisting of a mixture comprising 1,2-pentanediol and 2,3-pentanediol; a mixture comprising 1,2-hexanediol and 2,3-hexanediol; a mixture comprising 1,2-heptanediol and 2,3-heptanediol; a mixture comprising 1,2-octanediol and 2,3-octanediol; a mixture comprising 1,2-nonanediol and 2,3-nonanediol; a mixture comprising 1,2-decanediol and 2,3-decanediol; a mixture comprising 1,2-undecanediol and 2,3-undecanediol; a mixture comprising 1,2-dodecanediol and 2,3-decanediol, and Mixture containing 1,2-tridecanediol and 2,3-tridecanediol 1. A personal hygiene product, deodorant, antiperspirant, anti-acne product, or anti-dandruff product comprising:

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