Glutathione odor inhibitor

Abstract

To provide an odor change inhibiting agent for glutathione that inhibits odor change and quality degradation over time in topical skin agents containing glutathione.SOLUTION: An odor change inhibiting agent for glutathione includes a Rosa canina fruit extract as an active ingredient.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an agent for inhibiting the deodorization of glutathione, and more particularly to an agent for inhibiting the deodorization of glutathione-containing external skin preparations over time. [Background technology]

[0002] Sulfur-containing amino acids are beneficial to the body, possessing numerous physiological activities, including reducing and whitening effects. Numerous attempts have been made to utilize L-cysteine ​​in cosmetics, such as skin-whitening agents, using sulfur-containing amino acids. Among these, glutathione, a peptide containing sulfur-containing amino acid residues, has many beneficial effects, including antioxidant activity, active enzyme capture, antiallergic activity, detoxification, and melanin production inhibition, and has attracted attention in the fields of food, pharmaceuticals, and cosmetics.

[0003] Known examples include a whitening agent that combines glutathione with a plant of the genus Banyarum (e.g., Patent Document 1) and an immunostimulant that contains glutathione and prevents UV-induced decline in skin immune function (e.g., Patent Document 2).

[0004] On the other hand, sulfur-containing compounds are known to cause odor deterioration over time, and examples of using α-glucosylrutin as an odor inhibitor are known (see, for example, Patent Document 3). [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Laid-Open No. 2008-303180 [Patent Document 2] Japanese Patent Application Publication No. 11-049696 [Patent Document 3] Japanese Patent Application Laid-Open No. 2007-223935 Summary of the Invention [Problem to be solved by the invention]

[0006] The above-mentioned conventional skin preparations are referred to as an anti-odor agent for anti-odor agents for anti-odor agents for anti-odor agents for anti-odor agents for glutathione, but the anti-odor effect for anti-odor agents for glutathione has not been fully investigated.In this context, there is a demand for a method for preventing anti-odor agents for anti-odor agents for anti-odor agents for anti-odor agents for anti-odor agents for glutathione.

[0007] The present invention has been made in view of the above-mentioned problems, and its object is to provide an agent for inhibiting the odor deterioration of glutathione, which inhibits the odor deterioration and degradation of topical skin preparations containing glutathione over time. [Means for solving the problem]

[0008] As a result of intensive research conducted by the inventors to achieve the above-mentioned object, they discovered that by combining glutathione with rosemary extract, rosehip fruit extract, butylene glycol or white clover extract, the deterioration and odor of glutathione over time can be suppressed, and thus completed the present invention.

[0009] That is, the present invention is 1. A glutathione odor inhibitor with crab rose fruit extract as the active ingredient. 2. A method for inhibiting the offensive odor of glutathione by combining glutathione with rosehip fruit extract. [Effects of the Invention]

[0010] The glutathione odor inhibitor of the present invention can inhibit the deterioration of an external skin preparation composition containing glutathione from deteriorating with the passage of time. DETAILED DESCRIPTION OF THE INVENTION

[0011] The configuration of the present invention will be described in detail below. The present inventors have searched for substances that suppress the odor caused by the deterioration of glutathione over time from among various materials, and have found that rosemary extract, rosehip fruit extract, butylene glycol, and white clover extract suppress the deterioration of glutathione over time due to the deterioration of glutathione.

[0012] The glutathione odor inhibitor of the present invention can exert its effects by combining rosemary extract, rosehip fruit extract, butylene glycol, and white clover extract, which are described in detail below, with glutathione.

[0013] <Glutathione> The component (A) used in the topical skin composition of the present invention is glutathione. Glutathione is a peptide composed of three amino acids: glutamine, cysteine, and glycine. It is found in large amounts within the cells of living organisms and is commercially available as a functional ingredient.

[0014] Glutathione is known to have a strong antioxidant effect, neutralizing hydrogen peroxide and lipid peroxides and preventing rust in the body, and is used in topical skin preparation compositions to prevent skin aging such as age spots. However, glutathione is also known to emit an unpleasant sulfurous odor over time due to sulfur compounds.

[0015] <Rosemary extract> The rosemary used in this invention is an evergreen shrub native to the Mediterranean coastal region and belonging to the Lamiaceae family. Its small, elongated leaves have a sweet, refreshing fragrance. It is known that fresh or dried leaves are used as a spice and medicine (herb). Rosemary extract is known to have antioxidant effects on the skin through its SOD-like activity and anti-aging effects through its inhibition of neutrophil elastase activity.

[0016] The rosemary extract of the present invention may be produced by a known method, such as by pressing, solvent extraction, steam distillation, etc. These components are available as commercially available cosmetic ingredients, for example, Organic Rosemary Extract BG-50 manufactured by Koei Kogyo Co., Ltd.

[0017] <Rosa canina fruit extract> The Rosa canina used in the present invention is a plant of the Rosaceae family, also known as rose hip. The Rosa canina fruit used in the present invention is generally known to contain organic compounds such as sugars and polysaccharides, and antioxidants such as vitamin C and ferulic acid, but the factors that cause the Rosa canina fruit in the present invention to have the effects of the present invention are not limited to these components alone. Rosa canina fruit extract is known to be used for the purpose of astringent action on the skin and anti-pigmentation action by inhibiting kinesin.

[0018] The extract of the fruit of Rosa canina in the present invention may be produced by a known method, such as by squeezing, extraction with a solvent, steam distillation, etc. These components are available as raw materials for cosmetics, for example, Falcorex (manufactured by Ichimaru Falcos Co., Ltd.). Nobara B, etc. can be used.

[0019] <Butylene glycol (BG)> The butylene glycol used in the present invention is a dihydric alcohol represented by the following chemical formula. Butylene glycol is known to be used in cosmetics for its moisturizing effect, antiseptic aid, and solvent purposes. Butylene glycol may be produced from petroleum or plant biomass and is available as a cosmetic raw material. For example, butylene glycol manufactured by Daicel Chemical Industries, Ltd. can be used.

[0020] [ka]

[0021] <White clover extract> The white clover used in the present invention is a legume plant also known as clover. As a medicinal herb, white clover is known to be effective in alleviating colds and their associated symptoms, such as phlegm, gout, pimples, and bleeding. In the present invention, it has been discovered that (A) glutathione suppresses the odor caused by deterioration over time, making it an essential ingredient.

[0022] The white clover extract of the present invention may be produced by a known method, such as by squeezing, solvent extraction, steam distillation, etc. These components are available as commercially available cosmetic ingredients, for example, Hapicro manufactured by Ichimaru Pharcos Co., Ltd.

[0023] The glutathione odor inhibitor of the present invention can be used in general cosmetics, quasi-drugs, and pharmaceuticals. Its form is not particularly limited, and it may be liquid, gel, or solid. Furthermore, the form of the cosmetic is not particularly limited, and it can be used in basic cosmetics such as lotions, emulsions, creams, sunscreens, packs, massage products, beauty serums, cleansing products, and detergents, makeup cosmetics such as foundations, face powders, and concealers, hair cosmetics, body cosmetics, bath additives, and the like. [Example]

[0024] The present invention will now be described in detail with reference to examples, but is not limited thereto. Prior to the examples, the test and evaluation methods employed in each example will be described.

[0025] (Evaluation test of odor suppression effect) 10 g of the skin external preparation compositions of the Examples and Comparative Examples of the present invention were sealed in a glass bottle with a volume of 13 mL and sealed with a screw cap. Then, they were stored in an incubator set at 50°C for one month. Five evaluation panelists applied 0.5 mL of the skin external preparation compositions of the Examples and Comparative Examples of the present invention to the forearms of both arms after washing before and after storage, and a sensory evaluation was conducted on the difference in odor before and after storage using the following scoring system. The evaluation criteria were 5 people. The average overall score was used to classify the items as follows: <Score and details of odor suppression effect> 5 points: No difference in smell before and after storage 4 points: Almost no difference in smell before and after storage 3 points: There is a slight difference in smell before and after storage, but it is not unpleasant. 2 points: There is a difference in smell before and after storage 1 point: There is a big difference in the smell before and after storage, and the smell after storage is particularly unpleasant.

[0026] <Test Results> The results of glutathione's odor suppression effect for each ingredient are shown in Table 1. Rosemary extract, Rosa canina fruit extract, butylene glycol, and white clover extract were found to have a good odor suppression effect.

[0027] [Table 1]

[0028] Examples of formulations of topical skin preparation compositions using the glutathione odor inhibitor of the present invention are given below. Furthermore, when the topical preparation compositions of these examples were also examined for each of the above-mentioned odor inhibitory effects, they were found to have excellent properties in all respects.

[0029] Example 1 (lotion) (mass%) (1) Glutathione 0.001% (2) Rosemary leaf extract 0.1% (3) Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol 0.1% (4) Loquat leaf extract 0.1% (5) Peony root extract 0.1% (6) Rice bran extract 0.1% (7) Ethanol 5.0% (8) Glycerin 5.0% (9) 1,3-butylene glycol 4.0% (10) dipropylene glycol 4.0% (11) Sodium citrate 0.05% (12) Citric acid 0.01% (13) Polyoxyethylene hydrogenated castor oil 0.1% (14) Polyoxyethylene sorbitan monolaurate (20E.O.) 0.05% (15) Disodium edetate 0.005% (16) Maltitol 1.0% (17) Polyglycerin 0.3% (18) Methylgluceth-20 0.5% (19) Xanthan gum 0.03% (20) Hydrolyzed Collagen 0.001% (21) Pentylene Glycol 0.2% (22) Phenoxyethanol 0.3% (23) Methylparaben 0.01% (24) Purified water remainder

[0030] (Production method) (1) to (20) were added to (24) and dispersed with a propeller until uniformly dissolved (liquid A). (22) and (23) were dissolved in (21), and then added to liquid A and uniformly dissolved to prepare a lotion.

[0031] Example 2 (cream) (mass%) (1) Glutathione 0.01% (2) Rosemary leaf extract 0.1% (3) Saccharomyces / rice fermentation liquid 1.0% (4) Lactobacillus / lotus seed fermented liquid 1.0% (5) Glucosylceramide 0.001% (6) α-glucan 0.006% (7) Glycerin 5.0% (8) 1,3-butylene glycol 4.5% (9) Agar 1.0% (10) Sodium acrylate grafted starch 0.5% (11) Dipropylene glycol 6.0% (12) Hydrogenated lecithin 0.5% (13) Cholesterol 0.1% (14) Pentaerythrityl tetraethylhexanoate 2.0% (15) Dimer Dilinoleic Acid (Phytosteryl / Isostearyl / Cetyl / Stearyl / Behenyl) 0.5% (16) Disodium edetate 0.01% (17) Methylparaben 0.05% (18)Fragrance 0.01% (19) Purified water remainder

[0032] (Production method) (1) to (10), (16) to (17) were stirred and added to (19), which was then heated to 70°C and uniformly dissolved (liquid A). (11) to (15) were heated to 70°C and uniformly dissolved (liquid B). Liquid A was added to liquid B, and the mixture was dispersed in a homomixer until uniform, followed by cooling to 30°C. Then, (18) was added and the mixture was further dispersed in a homomixer until uniform, and the mixture was then filled into a container to prepare a cream.

[0033] Example 3 (gel cream) (mass%) (1) Glutathione 0.1% (2) Rosemary leaf extract 5.0% (3) Yuzu fruit extract 0.5% (4) Loquat leaf extract 0.5% (5) Rice bran extract 1.0% (6) Sodium stearoyl glutamate 0.5% (7) Glycerin 5.0% (8) 1,3-butylene glycol 7.0% (9) Maltitol 4.0% (10) Carbomer 0.5% (11) Stearic acid 0.5% (12) Behenyl alcohol 2.0% (13) Cholesterol 0.05% (14) Diisostearyl malate 1.0% (15) Dimethicone 0.5% (16) Glyceryl stearate 0.3% (17) Sorbitan isostearate 0.3% (18) Propanediol 1.0% (19) Disodium edetate 0.001% (20) Phenoxyethanol 0.1% (21) Methylparaben 0.05% (22) Purified water remainder

[0034] (Production method) (1) to (10), (19) to (21) were added to (22) and dissolved by heating at 80°C (liquid A). (11) to (18) were dissolved by heating at 80°C (liquid B). Liquid A was added to liquid B, and the mixture was uniformly dispersed using a homomixer, followed by cooling to 30°C. The mixture was then filled into a container to prepare a gel cream.

[0035] Example 4 (Cosmetic Serum) (% by mass) (1) Glutathione 0.1% (2) Rosemary leaf extract 5.0% (3) Ethanol 5.0% (4) Dipropylene glycol 7.0% (5) Polyoxyethylene hydrogenated castor oil 0.5% (6) Potassium hydroxide 0.01% (7) Disodium edetate 0.005% (8) Phenoxyethanol 0.6% (9) Methylparaben 0.1% (10) Carboxyvinyl polymer 0.01% (11) Xanthan gum 0.1% (12) Aloe extract 1.0% (13) Sage extract 1.0% (14) Rose flower extract 1.0% (15) Kiwi extract 1.0% (16) Peony Root Extract 1.0% (17) Soybean extract 1.0% (18) Polygonum Cuspidatum Root Extract 1.0% (19) Pomegranate Flower Extract 1.0% (20) Royal jelly extract 1.0% (21) Centella asiatica extract 1.0% (22) Ceramide II 0.001% (23) Sodium Hyaluronate 0.01% (24) Hydrolyzed Collagen 0.01% (25) Purified water remainder

[0036] (Production method) (1) to (24) were added to (25), heated to 70°C, and dispersed in a homomixer until uniform to prepare a cosmetic liquid.

[0037] Example 5 (Lotion) (% by mass) (1) Glutathione 0.001% (2) Rosa canina fruit extract 0.1% (3) Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol 0.1% (4) Loquat leaf extract 0.1% (5) Peony root extract 0.1% (6) Rice bran extract 0.1% (7) Ethanol 5.0% (8) Glycerin 5.0% (9) 1,3-butylene glycol 4.0% (10) dipropylene glycol 4.0% (11) Sodium citrate 0.05% (12) Citric acid 0.01% (13) Polyoxyethylene hydrogenated castor oil 0.1% (14) Polyoxyethylene sorbitan monolaurate (20E.O.) 0.05% (15) Disodium edetate 0.005% (16) Maltitol 1.0% (17) Polyglycerin 0.3% (18) Methylgluceth-20 0.5% (19) Xanthan gum 0.03% (20) Hydrolyzed Collagen 0.001% (21) Pentylene Glycol 0.2% (22) Phenoxyethanol 0.3% (23) Methylparaben 0.01% (24) Purified water remainder

[0038] (Production method) (1) to (20) were added to (24) and dispersed with a propeller until uniformly dissolved (liquid A). (22) and (23) were dissolved in (21), and then added to liquid A and uniformly dissolved to prepare a lotion.

[0039] Example 6 (Cream) (% by mass) (1) Glutathione 0.01% (2) Rosa canina fruit extract 1.0% (3) Saccharomyces / rice fermentation liquid 1.0% (4) Lactobacillus / lotus seed fermented liquid 1.0% (5) Glucosylceramide 0.001% (6) α-glucan 0.006% (7) Glycerin 5.0% (8) 1,3-butylene glycol 4.5% (9) Agar 1.0% (10) Sodium acrylate grafted starch 0.5% (11) Dipropylene glycol 6.0% (12) Hydrogenated lecithin 0.5% (13) Cholesterol 0.1% (14) Pentaerythrityl tetraethylhexanoate 2.0% (15) Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) 0.5% (16) Disodium edetate 0.01% (17) Methylparaben 0.05% (18)Fragrance 0.01% (19) Purified water remainder

[0040] (Production method) (1) to (10), (16) to (17) were stirred and added to (19), which was then heated to 70°C and uniformly dissolved (liquid A). (11) to (15) were heated to 70°C and uniformly dissolved (liquid B). Liquid A was added to liquid B, and the mixture was dispersed in a homomixer until uniform, followed by cooling to 30°C. Then, (18) was added and the mixture was further dispersed in a homomixer until uniform, and the mixture was then filled into a container to prepare a cream.

[0041] Example 7 (gel cream) (mass%) (1) Glutathione 0.1% (2) Rosa canina fruit extract 5.0% (3) Yuzu fruit extract 0.5% (4) Loquat leaf extract 0.5% (5) Rice bran extract 1.0% (6) Sodium stearoyl glutamate 0.5% (7) Glycerin 5.0% (8) 1,3-butylene glycol 7.0% (9) Maltitol 4.0% (10) Carbomer 0.5% (11) Stearic acid 0.5% (12) Behenyl alcohol 2.0% (13) Cholesterol 0.05% (14) Diisostearyl Malate 1.0% (15) Dimethicone 0.5% (16) Glyceryl stearate 0.3% (17) Sorbitan isostearate 0.3% (18) Propanediol 1.0% (19) Disodium edetate 0.001% (20) Phenoxyethanol 0.1% (21) Methylparaben 0.05% (22) Purified water remainder

[0042] (Production method) (1) to (10), (19) to (21) were added to (22) and dissolved by heating at 80°C (liquid A). (11) to (18) were dissolved by heating at 80°C (liquid B). Liquid A was added to liquid B, and the mixture was uniformly dispersed using a homomixer, followed by cooling to 30°C. The mixture was then filled into a container to prepare a gel cream.

[0043] Example 8 (Cosmetic Serum) (% by mass) (1) Glutathione 0.1% (2) Rosa canina fruit extract 5.0% (3) Ethanol 5.0% (4) Dipropylene glycol 7.0% (5) Polyoxyethylene hydrogenated castor oil 0.5% (6) Potassium hydroxide 0.01% (7) Disodium edetate 0.005% (8) Phenoxyethanol 0.6% (9) Methylparaben 0.1% (10) Carboxyvinyl polymer 0.01% (11) Xanthan gum 0.1% (12) Aloe extract 1.0% (13) Sage extract 1.0% (14) Rose flower extract 1.0% (15) Kiwi extract 1.0% (16) Peony Root Extract 1.0% (17) Soybean extract 1.0% (18) Polygonum Cuspidatum Root Extract 1.0% (19) Pomegranate Flower Extract 1.0% (20) Royal jelly extract 1.0% (21) Centella asiatica extract 1.0% (22) Ceramide II 0.001% (23) Sodium Hyaluronate 0.01% (24) Hydrolyzed Collagen 0.01% (25) Purified water remainder

[0044] (Production method) (1) to (24) were added to (25), heated to 70°C, and dispersed in a homomixer until uniform to prepare a cosmetic liquid.

[0045] Example 9 (lotion) (mass%) (1) Glutathione 0.001% (2) 1,3-butylene glycol 4.0% (3) Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol 0.1% (4) Loquat leaf extract 0.1% (5) Peony root extract 0.1% (6) Rice bran extract 0.1% (7) Ethanol 5.0% (8) Glycerin 5.0% (9) Dipropylene glycol 4.0% (10) Sodium citrate 0.05% (11) Citric acid 0.01% (12) Polyoxyethylene hydrogenated castor oil 0.1% (13) Polyoxyethylene sorbitan monolaurate (20E.O.) 0.05% (14) Disodium edetate 0.005% (15) Maltitol 1.0% (16) Polyglycerin 0.3% (17) Methylgluceth-20 0.5% (18) Xanthan gum 0.03% (19) Hydrolyzed Collagen 0.001% (20) Pentylene Glycol 0.2% (21) Phenoxyethanol 0.3% (22) Methylparaben 0.01% (23) Purified water remainder

[0046] (Production method) (1) to (19) were added to (23) and dispersed with a propeller until uniformly dissolved (liquid A). (21) and (22) were dissolved in (20), and then added to liquid A and uniformly dissolved to prepare a lotion.

[0047] Example 10 (cream) (mass%) (1) Glutathione 0.01% (2) 1,3-butylene glycol 4.5% (3) Saccharomyces / rice fermentation liquid 1.0% (4) Lactobacillus / lotus seed fermented liquid 1.0% (5) Glucosylceramide 0.001% (6) α-glucan 0.006% (7) Glycerin 5.0% (8) Agar 1.0% (9) Sodium acrylate grafted starch 0.5% (10) Dipropylene glycol 6.0% (11) Hydrogenated lecithin 0.5% (12) Cholesterol 0.1% (13) Pentaerythrityl tetraethylhexanoate 2.0% (14) Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) 0.5% (15) Disodium edetate 0.01% (16) Methylparaben 0.05% (17)Fragrance 0.01% (18) Purified water remainder

[0048] (Production method) (1) to (10), (15) to (16) were added to stirred (18) and heated to 70°C to dissolve uniformly (liquid A). (10) to (14) were heated to 70°C to dissolve uniformly (liquid B). Liquid A was added to liquid B and dispersed in a homogenous mixer until uniform, then cooled to 30°C, and then (17) was added and further dispersed in a homogenous mixer until uniform, and the mixture was filled into a container to prepare a cream.

[0049] Example 11 (gel cream) (mass%) (1) Glutathione 0.1% (2) 1,3-butylene glycol 7.0% (3) Yuzu fruit extract 0.5% (4) Loquat leaf extract 0.5% (5) Rice bran extract 1.0% (6) Sodium stearoyl glutamate 0.5% (7) Glycerin 5.0% (8) Maltitol 4.0% (9) Carbomer 0.5% (10) Stearic acid 0.5% (11) Behenyl alcohol 2.0% (12) Cholesterol 0.05% (13) Diisostearyl malate 1.0% (14) Dimethicone 0.5% (15) Glyceryl stearate 0.3% (16) Sorbitan isostearate 0.3% (17) Propanediol 1.0% (18) Disodium edetate 0.001% (19) Phenoxyethanol 0.1% (20) Methylparaben 0.05% (21) Purified water remainder

[0050] (Production method) (1) to (10) and (18) to (20) were added to (21) and dissolved by heating at 80°C (liquid A). (10) to (17) were dissolved by heating at 80°C (liquid B). Liquid A was added to liquid B, and the mixture was uniformly dispersed using a homomixer, followed by cooling to 30°C. The mixture was then filled into a container to prepare a gel cream.

[0051] Example 12 (Cosmetic Serum) (% by mass) (1) Glutathione 0.1% (2) 1,3-butylene glycol 6.0% (3) Ethanol 5.0% (4) Dipropylene glycol 5.0% (5) Polyoxyethylene hydrogenated castor oil 0.5% (6) Potassium hydroxide 0.01% (7) Disodium edetate 0.005% (8) Phenoxyethanol 0.6% (9) Methylparaben 0.1% (10) Carboxyvinyl polymer 0.01% (11) Xanthan gum 0.1% (12) Aloe extract 1.0% (13) Sage extract 1.0% (14) Rose flower extract 1.0% (15) Kiwi extract 1.0% (16) Peony Root Extract 1.0% (17) Soybean extract 1.0% (18) Polygonum Cuspidatum Root Extract 1.0% (19) Pomegranate Flower Extract 1.0% (20) Royal jelly extract 1.0% (21) Centella asiatica extract 1.0% (22) Ceramide II 0.001% (23) Sodium Hyaluronate 0.01% (24) Hydrolyzed Collagen 0.01% (25) Purified water remainder

[0052] (Production method) (1) to (24) were added to (25), heated to 70°C, and dispersed in a homomixer until uniform to prepare a cosmetic liquid.

Claims

1. A glutathione odor inhibitor with canina rose fruit extract as the active ingredient.

2. A method for inhibiting the offensive odor of glutathione by combining glutathione with rosehip fruit extract.

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