Synergy pulse generator, device and generation method

Abstract

The present invention provides a synergy pulse generating apparatus, device and method for selectively forming a first pulse signal and / or a second pulse signal having different widths to achieve the objective of applying a composite pulse to a load. [Solution] A synergy pulse generating device according to an embodiment of the present invention includes a drive circuit and a pulse generating circuit. The drive circuit receives a first control signal and a second control signal transmitted from a host device, converts the first control signal into a first drive signal, and converts the second control signal into a second drive signal. The pulse generating circuit includes a first power supply, a second power supply, a first pulse generating module, and a second pulse generating module. The first pulse generating module stores power supplied from the first power supply and discharges it under control of the first drive signal to form a first pulse signal. The second pulse generating module stores power supplied from the second power supply and discharges it under control of the second drive signal to form a second pulse signal.

Description

[Technical Field]

[0001] The present invention claims priority to Chinese patent application number CN202110921262.1 entitled "Synergy pulse generating device, system and generating method" and Chinese patent application number CN202110921264.0 entitled "Drive circuit, drive method and pulse generating system," the entire contents of which are incorporated herein by reference.

[0002] The present invention relates to pulse generation and medical device technology, and more particularly to synergy pulse generators, devices and methods. [Background technology]

[0003] Pulsed power technology is an electrical physics technology that rapidly compresses slowly accumulated high-density energy and converts it into a load or directly releases it. In recent years, as the application of pulsed power technology has expanded to fields such as medicine, environmental science, isotope science, food processing, electromagnetic compatibility testing, and bioengineering, the requirements for pulse generators have also changed. Summary of the Invention [Problem to be solved by the invention]

[0004] Conventional pulse generators have a complicated structure and usually only generate pulse signals with a specific width, which cannot meet the complex application needs of pulse technology.

[0005] The present invention aims to solve at least one of the above problems to some extent, and proposes a synergistic pulse generating apparatus, device and method for generating pulses of different widths to form even more pulse combinations. [Means for solving the problem]

[0006] According to a first aspect of the present invention, there is provided a synergy pulse generator for generating a pulse signal under the control of a host device. a drive circuit electrically connected to the host machine, receiving a first control signal transmitted from the host machine and converting the first control signal into a first drive signal, and receiving a second control signal transmitted from the host machine and converting the second control signal into a second drive signal; a pulse generation circuit including a first power source, a first pulse generation module electrically connected to the first power source, a second power source, and a second pulse generation module electrically connected to the second power source; the first pulse generation module is configured to store power provided by the first power source and discharge it under control of the first drive signal to form a first pulse signal applied to a load; the second pulse generation module is configured to store power provided by the second power source and discharge it under control of the second drive signal to form a second pulse signal applied to the load; The voltage of the second power supply is greater than the voltage of the first power supply, and the width of the second pulse is smaller than the width of the first pulse.

[0007] According to a second aspect of the present invention, there is provided a synergistic pulse generating device, comprising: a host machine that generates the control signal in response to an input command; and a synergy pulse generator according to the first aspect of the present invention.

[0008] According to a third aspect of the present invention, there is provided a synergistic pulse generation method for the synergistic pulse generator according to the first aspect of the present invention, the synergistic pulse generation method comprising: the first pulse generating module stores power supplied from the first power supply, and the second pulse generating module stores power supplied from the second power supply; The drive circuit receives a first control signal transmitted by a host machine and converts the first control signal into a first drive signal, and the drive circuit receives a second control signal transmitted by the host machine and converts the second control signal into a second drive signal; a first pulse generating module receiving the first drive signal to form a first pulse signal to be applied to a load and discharging under control of the first drive signal; and a second pulse generating module receiving the second drive signal to form a second pulse signal to be applied to the load and discharging under control of the second drive signal; The voltage of the second power supply is greater than the voltage of the first power supply, and the width of the second pulse signal is smaller than the width of the first pulse signal. [Effects of the Invention]

[0009] The beneficial technical effects of the technical solutions provided by the embodiments of the present invention are as follows: In the synergy pulse generating apparatus, device, and generating method according to the embodiments of the present invention, a first control signal and a second control signal transmitted from a host device are converted into a first drive signal and a second drive signal, respectively, by a drive circuit, and the pulse generating circuit can selectively form the first pulse signal and / or the second pulse signal having different widths based on the first drive signal and the second drive signal. This achieves the purpose of applying a composite pulse signal to a load. For example, if the load is a tumor cell, the role of the composite pulse is advantageous in enhancing the ablation effect on the tumor cell.

[0010] Certain aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be apparent from the description, or may be learned by practice of the invention. [Brief explanation of the drawings]

[0011] The above and / or additional aspects and advantages of the present invention will become apparent from the following description of the embodiments through the drawings. [Figure 1]A diagram showing a synergy pulse generating device according to an embodiment of the present invention connected to a host machine and a load. [Figure 2] FIG. 10 is a diagram showing the configuration of another pulse generating circuit of a synergy pulse generating device according to an embodiment of the present invention. [Figure 3] 10A and 10B are diagrams illustrating contact between an output module and a load according to an embodiment of the present invention. [Figure 4] FIG. 10 is a diagram showing the configuration of another pulse generating circuit of a synergy pulse generating device according to an embodiment of the present invention. [Figure 5] FIG. 10 is a diagram showing the configuration of yet another pulse generating circuit of a synergy pulse generating device according to an embodiment of the present invention. [Figure 6] FIG. 6 is a diagram showing a current in a charging state of the pulse generating circuit shown in FIG. 5. [Figure 7] FIG. 6 is a diagram showing a current in a discharging state of the pulse generating circuit shown in FIG. 5. [Figure 8] FIG. 2 is a diagram showing the configuration of a drive circuit in a synergy pulse generating device according to an embodiment of the present invention. [Figure 9] FIG. 10 is a diagram showing the distribution of synergy pulse generators on a circuit board according to an embodiment of the present invention. [Figure 10] FIG. 10 shows the distribution of another synergy pulse generator on a circuit board according to an embodiment of the present invention. [Figure 11] 1 is a diagram showing the configuration of a synergy pulse generator with a shield structure according to an embodiment of the present invention; [Figure 12] FIG. 10 is a diagram showing one pulse signal generated without providing a conventional shielding structure. [Figure 13] FIG. 10 illustrates one pulse signal generated after providing a shielding structure according to an embodiment of the present invention. [Figure 14] FIG. 1 is a diagram showing a flow chart of a synergy pulse generation method according to an embodiment of the present invention. [Figure 15] FIG. 10 is a diagram showing the flow of step S2 in the synergy pulse generation method according to an embodiment of the present invention. [Figure 16]FIG. 10 is a diagram showing the flow of step S3 in the synergy pulse generation method according to an embodiment of the present invention. [Figure 17] FIG. 2 is a diagram showing the configuration of a drive circuit according to an embodiment of the present invention. [Figure 18] FIG. 10 is a block diagram showing another driving circuit according to an embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0012] The present invention will be described in detail below. An example of an embodiment of the present invention is shown in the drawings, and identical or similar elements are represented by the same or similar reference numerals from the beginning in the drawings. Note that a detailed description of the illustrated features of the present invention, which are known technologies, is not necessary and will be omitted. The embodiments described below with reference to the drawings are merely examples and should not be construed as limiting the present invention.

[0013] Those skilled in the art will understand that unless otherwise defined, all terms (including technical and scientific terms) used herein are the same as commonly understood by those of ordinary skill in the art to which this invention pertains. Terms such as general dictionary terms should be interpreted as meanings that are consistent with the meanings in the conventional context, and should not be construed as referring to an ideal or formal meaning unless specifically defined as herein.

[0014] Those skilled in the art will understand that the singular terms "a," "one," "the," and "the" as used herein also include the plural, unless otherwise specified. It should be noted that the term "comprising" in the present specification means that features, integers, steps, operations, elements, and / or modules are present, but does not exclude the presence or addition of other features, integers, steps, operations, elements, modules, and / or groups thereof.

[0015] In recent years, as the application of pulsed power technology has expanded to fields such as medicine, environmental science, isotope science, food processing, electromagnetic compatibility testing, and bioengineering, the requirements for pulse generators have also been changing.

[0016] Taking the medical field as an example, the inventors of the present invention have discovered that when using electroablation technology to ablate tumor cells, the combined use of multiple pulses with different pulse widths can sometimes achieve better ablation effects than a single pulse. For example, when microsecond pulses are applied to tumor cells, they have a large ablation area but a low ablation rate for tumor cells, especially malignant tumor cells with high distortion, while when nanosecond pulses are applied to tumor cells, they have a high ablation rate but a small ablation area. The combined use of microsecond and nanosecond pulses can significantly improve the ablation effect of tumor cells. In addition to ablation of tumor cells by reversible electroporation induced by nanosecond pulses, applying a microsecond or millisecond pulse in combination during the duration of irreversible electroporation induced by nanosecond pulses can also perforate the cell membrane, allowing the electric field of the microsecond or millisecond pulse to penetrate the interior of the cells and further induce apoptosis. This results in a higher ablation effect than when using a single nanosecond, microsecond, or millisecond pulse.

[0017] To generate a composite pulse, a corresponding pulse generator is required, whereas conventional pulse generators have a complicated configuration and can only generate pulse signals with a specific width, which cannot meet the complex application needs of pulses.

[0018] The present invention proposes a synergy pulse generator, device and method that aims to solve at least one of the above problems to some extent.

[0019] The following provides a detailed description of the technical solution of the present invention and how the technical problem is solved by the technical solution of the present invention through specific examples.

[0020] The present invention provides a synergy pulse generator that generates a pulse signal based on a control signal under the control of a host machine 1. For convenience of explanation, the signal output by the synergy pulse generator is also referred to as a synergy pulse or a composite pulse. As shown in Figure 1, the synergy pulse generator of this embodiment includes a drive circuit 2 and a pulse generation circuit 3 electrically connected to the drive circuit 2. The drive circuit 2 is electrically connected to the host machine 1.

[0021] The drive circuit 2 is electrically connected to the host unit 1 and configured to receive a first control signal transmitted from the host unit 1 and convert the first control signal into a first drive signal, and to receive a second control signal transmitted from the host unit 1 and convert the second control signal into a second drive signal.

[0022] The pulse generation circuit 3 includes a first power supply and a first pulse generation module 31 electrically connected to the first power supply, and a second power supply and a second pulse generation module 32 electrically connected to the second power supply. The first pulse generation module 31 is configured to store power provided from the first power supply and discharge the power under control of a first drive signal to form a first pulse signal to be applied to the load 4. The second pulse generation module 32 stores power provided from the second power supply and discharges the power under control of a second drive signal to form a second pulse signal to be applied to the load 4. In some embodiments, the voltage of the second power supply is greater than the voltage of the first power supply, the width of the second pulse is smaller than the width of the first pulse, and the time at which the second pulse generation module 32 receives the second drive signal is different from the time at which the first pulse generation module 31 receives the first drive signal.

[0023] The fact that the time when the second pulse generating module 32 receives the second drive signal is different from the time when the first pulse generating module 31 receives the first drive signal means that when the second pulse generating module 32 receives the second drive signal, the first pulse generating module 31 does not receive the first drive signal, and when the first pulse generating module 31 receives the first drive signal, the second pulse generating module 32 does not receive the second drive signal. That is, the first pulse signal and the second pulse signal are not generated simultaneously so as not to interfere with each other.

[0024] In this embodiment, the synergy pulse generator converts a first control signal and a second control signal transmitted from a host device 1 into a first drive signal and a second drive signal, respectively, using a drive circuit 2. The pulse generation circuit 3 selectively generates a first pulse signal and / or a second pulse signal having different widths based on the first drive signal and the second drive signal. This achieves the purpose of applying the composite pulse signal to a load 4. For example, if the load 4 is a tumor cell, the action of the composite pulse is advantageous in improving the ablation effect on the tumor cell. Here, the first pulse signal can be a microsecond pulse signal or a millisecond pulse signal, and the second pulse signal can be a nanosecond pulse signal.

[0025] 2, in the synergy pulse generating device, the pulse generating circuit 3 includes a first earth-fault module 5 and a second earth-fault module 6. The first earth-fault module 5 is electrically connected to the first pulse generating module 31 and ground, respectively, and is configured to connect the first pulse generating module 31 and ground under control of a first earth-fault signal so as to discharge residual power in the first pulse generating module 31. The second earth-fault module 6 is electrically connected to the second pulse generating module 32 and ground, respectively, and is configured to connect the second pulse generating module 32 and ground under control of a second earth-fault signal so as to discharge residual power in the second pulse generating module 32.

[0026] In a specific embodiment, as shown in FIG. 2 , the first ground-fault module 5 is a first relay, and the second ground-fault module 6 is a second relay. When the first relay receives a first ground-fault signal, it becomes conductive, thereby connecting the first pulse generating module 31 to ground and discharging the residual power in the first pulse generating module 31 to ground. Similarly, the residual power in the second pulse generating module 32 can also be discharged to ground. Thus, the first and second ground-fault signals can be connected by manually touching the relay, or by an electrical signal or the like. Alternatively, the ground-fault module may be implemented as another element capable of functioning as a switch, such as a transistor, a button-type switch, or the like.

[0027] Specifically, as shown in Figure 2, the leakage current operation is normally performed when the synergy pulse generator stops operating, preventing residual power in the synergy pulse generating circuit 3 from causing a malfunction the next time the machine is turned on, and also preventing electric shock while the synergy pulse generating circuit 3 is turned off. Of course, the synergy pulse generator may also perform leakage current operation when turned on, further preventing residual power in the pulse generator from causing a malfunction when turned on.

[0028] In some preferred embodiments, as shown in FIG. 2 , the synergistic pulse generator further includes an output module 7 electrically connected to the first pulse generating module 31 and the second pulse generating module 32, respectively, and configured to apply the first pulse signal and / or the second pulse signal to the load 4 under control of a trigger command. Specifically, when the synergistic pulse generating circuit 3 of this embodiment is applied to medical treatment or medical and biological experiments, the load 4 may be a location in a living body, such as a cancer displacement site in a cancer patient, or an extracorporeal tissue, organ, or cell group. In the synergistic pulse generator of this embodiment, the output module 7 controls the application of the first pulse signal and / or the second pulse signal to the load 4, thereby realizing controllability of the pulse acting on the load 4 and improving the pulse acting effect.

[0029] Alternatively, as shown in Fig. 3, in the synergy pulse generating device of this embodiment, the output module 7 has a trigger unit 71 and at least one pair of electrodes 72 electrically connected to the trigger unit 71. The trigger unit 71 is electrically connected to the first pulse generating module 31 and the second pulse generating module 32, respectively. The electrodes 72 are for contacting the load 4, and the trigger unit 71 is configured to be conductive when triggered by a trigger command so as to transmit a first pulse signal and / or a second pulse signal to the electrodes 72.

[0030] Alternatively, as shown in FIG. 5 , the output module 7 further includes a trigger switch 73 associated with the trigger unit 71. Specifically, when the synergy pulse generation circuit 3 of this embodiment is applied to a medical device, such as an electrical ablation device, the trigger switch 73 may be a foot switch, and the trigger unit 71 may be a relay. When the foot switch is triggered, this trigger operation becomes a trigger command, and the trigger unit 71 (i.e., this relay) is turned on by being triggered by this trigger command. As a result, the first pulse signal and / or the second pulse signal is output to the electrode 72 to act on the load 4 in contact with the electrode 72.

[0031] 5, the output module 7 includes a multiplexer 74 that converts the same signal into multiple signals, two for each counter electrode 72. The multiplexer 74 can be scalable, for example, to use only one pair of electrodes 72 under certain conditions, but four, six, or even more multiplexers 74 can be used to meet the signal requirements of multiple pairs of electrodes 72 as needed.

[0032] In some preferred embodiments, as shown in FIG. 2 , in the synergy pulse generator, the pulse generation circuit 3 further includes a resistor 8 and a monitor module 9. The resistor 8 is electrically connected to the first pulse generation module 31, the second pulse generation module 32, and ground, respectively. A first pulse signal and / or a second pulse signal is further applied to the resistor 8. The monitor module 9 includes a first monitor unit 91 and a second monitor unit 92. The first monitor unit 91 is configured to monitor a current output by the first pulse signal and / or the second pulse signal. The second monitor unit 92 is configured to monitor a voltage applied to the resistor 8 by the first pulse signal and / or the second pulse signal.

[0033] Of course, only one of the monitor units may be used to monitor either the output voltage or the current of the synergy pulse signal. For example, only the first monitor unit 91 may be used, and in this case, the first monitor unit 91 may be configured as a voltage sensor or a current sensor.

[0034] 2, the first monitor unit 91 is electrically connected to the first pulse generating module 31 and the second pulse generating module 32, and the second monitor unit 92 is electrically connected to the first pulse generating module 31 and the second pulse generating module 32, respectively. Because the branch circuit including the resistor 8 and the branch circuit including the load 4 are connected in parallel, the resistor 8 and the load 4 simultaneously receive the same pulse signal, and the monitor module 9 monitors the voltage applied to the resistor 8 by the first pulse signal and / or the second pulse signal, and also monitors the current output by the first pulse signal and / or the second pulse signal, simultaneously.

[0035] Alternatively, as shown in FIG. 5, the first monitor unit 91 includes a first Pearson coil, and the second monitor unit 92 includes a second Pearson coil. The first Pearson coil is arranged to induce a current output by the first pulse signal and / or the second pulse signal. The second Pearson coil is configured to induce a voltage applied to the resistor 8 by the first pulse signal and / or the second pulse signal. This allows the current and voltage output by the first pulse signal and / or the second pulse signal to be monitored.

[0036] In a specific embodiment, a first pulse signal and a second pulse signal having the parameters of current and voltage applied to the resistor 8 are generated. The two Pearson coils can also induce corresponding currents and voltages. When the induction results of the two Pearson coils match the parameters of the first pulse signal and the second pulse signal, the Synergy pulse generating circuit 3 is in a normal operating state. When the induction results of the two Pearson coils deviate from the parameters of the first pulse signal and the second pulse signal, the Synergy pulse generating device is determined to be in a non-operating state, so that an operator can immediately detect the fault and take corresponding measures.

[0037] For example, when the synergy pulse generating circuit 3 in this embodiment is applied to the medical field, i.e., when it is applied to a pulse treatment device, it can determine whether the first pulse and / or the second pulse outputted are normal based on the monitoring results provided by the monitor module 9, and the coordination between the output at the load 4 and the set output parameters is maintained.

[0038] Specifically, in the synergy pulse generating device of this embodiment, as shown in Figure 2, the pulse generating circuit 3 includes a first power supply U1, a first pulse generating module 31 electrically connected to the first power supply U1, a second power supply U2, and a second pulse generating module 32 electrically connected to the second power supply U2.

[0039] As shown in FIG. 2, the first pulse generating module 31 includes n (n is an integer of 1 or more) stages of first pulse generating units 311, and the first pulse generating units 311 receive and store power supplied from a first power supply U1, and upon receiving a first drive signal, release the stored power. Upon receiving the first drive signal, x (x is an integer of 1 or more and n or less) first pulse generating units 311 discharge to form a first pulse signal to be applied to the load 4.

[0040] As shown in FIG. 2, the second pulse generating module 32 includes m (where y is an integer greater than or equal to 1) stages of second pulse generating units 321, and the second pulse generating units 321 receive and store power supplied from the second power supply U2, and upon receiving a second drive signal, release the stored power. Upon receiving the second drive signal, y (where y is an integer greater than or equal to 1 and less than or equal to m) second pulse generating units 321 discharge to form a second pulse signal to be applied to the load 4.

[0041] For convenience of explanation, in the following embodiments, the voltage of the first power supply U1 is referred to as a first voltage, and the voltage of the second power supply U2 is referred to as a second voltage.

[0042] As shown in FIG. 2 , theoretically, each of the x first pulse generating units 311 receiving the first drive signal discharges at a first voltage. However, in practice, the discharge voltage of each first pulse generating unit 311 is slightly lower than the first voltage due to factors such as the equivalent impedance of each element of the pulse generating circuit 3. However, since the difference between the actual discharge voltage of each first pulse generating unit 311 and the first voltage is generally small, the voltage of the first pulse signal applied to the load 4 during the discharge of each first pulse generating module 311 can be approximated to x times the first voltage. Similarly, the voltage of the second pulse signal applied to the load 4 during the discharge of the second pulse generating module 32 can be approximated to y times the second voltage. For convenience of explanation, in the following examples, the actual voltage values ​​of the first pulse generating unit 311 and the second pulse generating unit 321 during discharge will be omitted and will be referred to as the first voltage and the second voltage. Based on the above description, by setting the number of first pulse generating units 311 that discharge simultaneously and the number of second pulse generating units 321 that discharge simultaneously, the voltage of the first pulse signal and the voltage of the second pulse signal can be adjusted, and in a specific embodiment, by taking into account the relationship between the power supply voltage and the actual discharge voltage, the voltage of the generated pulse signal can be adjusted more precisely.

[0043] Different pulse combinations can be formed by different settings of the first drive signal and the second drive signal. For example, in one specific embodiment, the pulse group includes a plurality of first pulse groups, where two adjacent first pulse groups are spaced apart by a time t1, each first pulse group includes a number of first pulse signals, and two adjacent first pulse signals are spaced apart by a time t2. In another specific embodiment, the pulse group includes a plurality of second pulse groups, where two adjacent second pulse groups are spaced apart by a time t3, each second pulse group includes b number of second pulse signals, and two adjacent second pulse signals are spaced apart by a time t4. In yet another specific embodiment, the pulse combination includes a plurality of first pulse signals and a plurality of second pulse signals. The first pulse signals and the second pulse signals may be applied alternately to the load 4, or the second pulse signal may be applied to the load 4 after all first pulse signals have been applied to the load 4. Alternatively, the first pulse signal is applied to the load 4 after all the second pulse signals have been applied to the load 4. These first pulse signals may form a plurality of first pulse groups, and these second pulse signals may form a plurality of second pulse groups. The first pulse groups and the second pulse groups are applied to the load 4 alternately.

[0044] In the above-mentioned embodiments, the selectable blocks of the pulse generating circuit 2 in the synergy pulse generating device have been described. In the following embodiments, the configuration of the first pulse generating unit 311 in each stage in the first pulse generating module 31 and the connection relationship to the first pulse generating unit 311 in each stage, as well as the configuration of the second pulse generating unit 321 in each stage in the second pulse generating module 32 and the connection relationship to the second pulse generating unit 321 in each stage will be described in detail.

[0045] In one optional embodiment, as shown in FIG. 4, the first pulse generating unit 311 in the synergy pulse generating circuit 3 includes a first memory unit 3111, a first switch unit 3112, and a first off unit 3113, and the second pulse generating unit 321 includes a second memory unit 3211, a second switch unit 3212, and a second off unit 3213.

[0046] 4, the first switch unit 3112 is arranged to be turned on under control of the first drive signal so as to serially connect and discharge the first memories 3111 in the same stage as the first switch unit 3112 that has received the first drive signal to form the first pulse signal. The first off unit 3113 is arranged so that only current flows from the first power supply U1 to the first pulse generating unit 311, or flows from the first pulse generating unit 311 of the current stage to the first pulse generating unit 311 of the next stage.

[0047] 4, the second switch unit 3212 is arranged to be turned on under control of the second drive signal so as to connect in series the second memories 3211 in the same stage as the second switch unit 3212 that has received the second drive signal to form a second pulse signal and cause discharge. The second off unit 3213 is arranged so that only current flows from the second power supply U2 to the second pulse generating unit 321, or flows from the second pulse generating unit 321 of the current stage to the second pulse generating unit 321 of the next stage.

[0048] Furthermore, as shown in FIG. 4, both ends of the first memory unit 3111 of each stage are electrically connected to both ends of the first power supply U1. The control end of the first switch unit 3112 of each stage receives a first drive signal, and is arranged so that the first end and second end of the first switch unit 3112 of each stage are electrically connected to the first end of the first memory unit 3111 of the current stage and the second end of the first memory unit 3111 of the next stage, respectively. Both ends of the second memory unit 3211 of each stage are electrically connected to both ends of the second power supply U2. The control end of the second switch unit 3212 of each stage receives a second drive signal, and is arranged so that the first end and second end of the second switch of each stage are electrically connected to the first end of the second memory unit 3211 of the current stage and the second end of the second memory unit 3211 of the next stage, respectively.

[0049] In some embodiments, the first memory unit 3111 includes a first capacitor, and the second memory unit 3211 includes a second capacitor. The first switch unit 3112 includes a first solid-state switch element, and the second switch unit 3212 includes a second solid-state switch element. The first off unit 3113 includes a first off element and a second off element, and the second off unit 3213 includes a third off element and a fourth off element. The first off element includes a first diode, the second off element includes a second diode, the third off element includes a third diode, and the fourth off element includes a fourth diode. That is, a capacitor is used as the memory cell, a solid-state switch element is used as the switch cell, and a diode is used as the off element. The solid-state switch element can be realized using a metal oxide semiconductor field effect transistor (MOSFET), an insulated gate bipolar transistor (IGBT), a triode, or the like.

[0050] 5, in the pulse generating circuit 3, the first pulse generating module 31 includes four stages of first pulse generating sections 311, and the second pulse generating module 32 includes four stages of second pulse generating sections 321, where both n and m are 4. Note that this is merely an example and does not limit the number of stages of first pulse generating sections 311 in the first pulse generating module 31 or the number of stages of second pulse generating sections 321 in the second pulse generating module 32.

[0051] Referring to FIG. 5, the first switch units 3112 in the first to fourth stages, that is, the first solid-state switch elements in the first to fourth stages, are respectively solid-state switch elements S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 , and a solid-state switching element S 1-4 The first memory units of the first to fourth stages are each connected to a capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4The first off elements of the first to fourth stages are diodes D 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 The second off elements of the first to fourth stages are diodes D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 is.

[0052] As shown in FIG. 5, the second switch units 3212 of the first to fourth stages, that is, the second triodes of the first to fourth stages, are respectively constituted by solid-state switch elements S 2-1 , solid-state switching element S 2-2 , solid-state switching element S 2-3 , and a solid-state switching element S 2-4 The first to fourth second storage units 3211 are connected to the capacitors C 2-1 , capacitor C 2-2 , capacitor C 2-3 and capacitor C 2-4 The third off elements of the first to fourth stages are diodes D 3-1 , diode D 3-2 , diode D 3-3 and diode D 3-4 The fourth elements of the first to fourth stages are turned off, respectively, by the diodes D 4-1 , diode D 4-2 , diode D 4-3 and diode D 4-4 is.

[0053] Referring to FIG. 6, the first power supply U1 and the second power supply U2 are both voltage sources, and the solid-state switching element S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 , and a solid-state switching element S 1-4 receives the third drive signal, the solid-state switch element S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3and solid-state switch element S 1-4 Both diodes are in the off state. 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 , diode D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 Each of these has a one-way conduction function. 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 are in a parallel connection relationship and are electrically connected to the first terminal and the second terminal of the first power supply U1, that is, they are both electrically connected to the positive and negative terminals of the first power supply U1. When charging is completed, the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 The potential difference between both ends of each is the first voltage.

[0054] Similarly, referring to FIG. 6, solid-state switch element S 2-1 , solid-state switch element S 2-2 , solid-state switch element S 2-3 , and solid-state switch element S 2-4 When the fourth drive signal is received, the capacitor C 2-1 , capacitor C 2-2 , capacitor C 2-3 , and capacitor C 2-4 are in a parallel connection relationship and are electrically connected to the first and second terminals of the second power supply U2, i.e., the positive and negative terminals of the second power supply U2, respectively. When charging is completed, the capacitor C 2-1 , capacitor C 2-2 , capacitor C 2-3 and capacitor C 2-4 The potential difference between both ends of the two terminals is the second voltage.

[0055] As shown in Figure 7, the solid-state switch element S 1-1 , solid-state switching element S1-2 , solid-state switching element S 1-3 , and a solid-state switching element S 1-4 When both of them receive the first drive signal, the solid-state switch element S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 and solid-state switch element S 1-4 Both diodes are in the on state. 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 , diode D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 has a one-way conduction function, so the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 are in series, and the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 are discharged at the same time. In addition, since the discharge voltages are both the first voltage, the voltage of the formed first pulse signal is four times the first voltage.

[0056] Similarly, as shown in FIG. 7, the solid-state switch element S 2-1 , solid-state switch element S 2-2 , solid-state switch element S 2-3 , and solid-state switch element S 2-4 When any of the solid-state switch elements S 2-1 , solid-state switch element S 2-2 , solid-state switch element S 2-3 and solid-state switch element S 2-4 are both in the on state. 2-1 , capacitor C 2-2 , capacitor C 2-3 and capacitor C 2-4 are in series, and the capacitor C 2-1 , capacitor C 2-2 , capacitor C2-3 and capacitor C 2-4 discharge simultaneously, and the discharge voltages are both the second voltage, so the voltage of the formed second pulse signal is four times the second voltage.

[0057] As shown in Figure 8, in the pulse generating device of this embodiment, the driving circuit 2 includes an electro-optical conversion module 21, a signal processing module 23, and optical fibers 22 connected to the electro-optical conversion module 21 and the signal processing module 23, respectively, and the electro-optical conversion module 21 is electrically connected to the host machine 1, and the signal processing module 23 is electrically connected to the pulse generating circuit 3.

[0058] The electrical-optical conversion module 21 is configured to receive a first control signal and a second control signal, convert the first control signal into a first drive optical signal, convert the second control signal into a second drive optical signal, and transmit the first drive optical signal and the second drive optical signal to the signal processing module 23 via the optical fiber 22.

[0059] The signal processing module 23 receives the first optical drive signal and the second optical drive signal, converts the first optical drive signal into a first electrical drive signal, converts the second optical drive signal into a second electrical drive signal, processes the first electrical drive signal to obtain the first drive signal, processes the second electrical drive signal to obtain the second drive signal, and transmits the first and second drive signals to the pulse generating circuit 3.

[0060] The driving circuit 2 of this embodiment converts the control signal into a driving optical signal, and processes the driving optical signal through photoelectric conversion, thereby isolating the low-voltage part from the high-voltage pulse generating circuit 3 to obtain the driving signal, reducing the electromagnetic interference caused by the pulse generating circuit 3 to the low-voltage part, and improving the accuracy of the driving signal, thereby improving the accuracy of the pulse signal.

[0061] 17, in some embodiments, the electrical-to-optical conversion module 21 includes a buffer unit 211, a first signal amplifier unit 212, and a first conversion unit 213. The buffer unit 211 is configured to receive and buffer a control signal.

[0062] 18, the buffer unit 211 may be a multi-buffer having k (k is an integer greater than 1) signal buffer channels 2111 that receive one-way control signals and store the control signals. In one specific embodiment, the multi-buffer may be an 8-way buffer of model number 74LVC245, but of course, buffers of other model numbers and other numbers of signal buffer channels 2111 may be selected according to specific implementation requirements.

[0063] It should be noted that instead of all k signal buffer channels 2111 receiving the control signal at the same time, some of the signal buffer channels 2111 may receive the control signal, and the drive signal may be acquired through processing in the next multiple parts.

[0064] As shown in FIG. 17, the first signal amplifier 212 is electrically connected to the buffer unit 211 and is arranged to amplify the control signal of the buffer.

[0065] 18, in some embodiments, the first signal amplification unit 212 includes k first amplification subunits 2121, each electrically connected to one signal buffer channel 2111. The first amplification subunit 2121 performs amplification processing on the control signal stored in the corresponding signal buffer channel 2111. In this embodiment, "each signal buffer path 2111" refers to the signal buffer path 2111 electrically connected to the corresponding first amplification subunit 2121, and in the following embodiments, it also refers to the electrical connection or communication connection formed between the two, and the description thereof will be omitted.

[0066] As shown in FIG. 17, the first conversion unit 213 is electrically connected to the first signal amplification unit 212 and the optical fiber 22, and is configured to perform electrical-to-optical conversion on the control after the amplification process to obtain a driving optical signal, and transmit the driving optical signal to the signal processing module 23 via the optical fiber 22.

[0067] 18, the first converting unit 213 is an optical signal transmitter including k electrical-to-optical conversion channels 2311. Each electrical-to-optical conversion channel 2311 is electrically connected to one first amplifying sub-unit 2121. The electrical-to-optical conversion channel 2311 converts the control signal amplified by the corresponding first amplifying sub-unit 2121 into an optical driving signal, which is transmitted to the signal processing module 23 through the optical fiber 22. In one specific embodiment, the optical signal transmitter may be an optical fiber transmitter.

[0068] In the driving circuit 2 of this embodiment, the above-mentioned electro-optical conversion module 21 is used to buffer the control signal first, thereby improving the transmission speed of the driving circuit 2, and further amplifying the control signal to strengthen the control signal and reduce the impact of electromagnetic interference on the control signal.

[0069] As shown in FIG. 17, in the driving circuit 2 according to this embodiment, the signal processing module 23 includes a second conversion unit 231 and a second signal amplification unit 232.

[0070] The second converter 231 is connected to the optical fiber 22 and configured to receive the optical driving signal and convert the optical driving signal into an electrical driving signal. Specifically, as shown in Fig. 18, the second converter 231 is an optical signal receiver, which includes k opto-electrical conversion channels 2311 that receive one optical driving signal and convert the received optical driving signal into an electrical driving signal. In a specific embodiment, the optical signal receiver is an optical fiber receiver. Based on the specific configuration of the electrical-to-optical conversion module 21 in the above embodiment, each opto-electrical conversion path 2311 is communicatively connected to one electrical-to-optical conversion path 2311 via an optical fiber.

[0071] 17, the second signal amplifier 232 is electrically connected to the second converter 231 and is arranged to amplify the driving electrical signal to obtain the driving signal. Specifically, as shown in Fig. 18, the second signal amplifier 232 has k second amplifier sub-units 2321 electrically connected to each photoelectric conversion channel 2311 of one second converter 231, and the two signal amplifiers amplify the corresponding driving electrical signal to obtain the driving signal.

[0072] In the driving circuit 2 according to this embodiment, the above-mentioned signal processing module 23 is used to amplify the driving electric signal so as to reduce the influence of electromagnetic interference on the control signal.

[0073] As shown in FIG. 17, in the driving circuit 2 according to this embodiment, the signal processing module 23 may further include a first filter section 233 and a second filter section 234.

[0074] 17, the first filter unit 233 is electrically connected to the second conversion unit 231 and the second signal amplification unit 232, and is configured to perform a first filtering process on the driving electrical signal. Specifically, as shown in Fig. 18, the first filter unit 233 includes k first filter sub-units 2331 electrically connected to each photoelectric conversion channel 2311, and each first filter sub-unit 2331 performs a first filtering process on the driving signal converted by the corresponding photoelectric conversion channel 2311. In one specific embodiment, the first filter unit 233 is an RC filter circuit.

[0075] 17, the second filter unit 234 is electrically connected to the second signal amplifier unit 232 and the pulse generation circuit 3, and is configured to perform second filtering on the drive signal and transmit the second-filtered drive signal to the pulse generation circuit 3. Specifically, as shown in FIG. 18, the second filter unit 234 includes k second filter sub-units 2341, and each second filter sub-unit 2341 is electrically connected to one second amplifier sub-unit 2321. The second filter sub-unit 2341 performs second filtering on the drive electrical signal obtained by amplification by the corresponding second amplifier unit 2321, and the second-filtered drive signal is transmitted to the pulse generation circuit 3. In one specific embodiment, the second filter unit 234 is an RC filter circuit.

[0076] Before the two filter sections were added, the pulses generated by the pulse generating circuit 3 had a large tail, but after the two filter sections were added, high frequency interference could be eliminated and there was no tail in the pulses generated by the pulse generating circuit 3. Thus, by adding the two filter sections, the driver circuit 2 according to this embodiment can further reduce the effects of electromagnetic interference on the drive signal.

[0077] As shown in Figure 9, the pulse generating device in this embodiment further includes a circuit board PCB including a first portion 10 and a second portion 20 located on the first portion 10 side, and a drive circuit 2 is arranged in the first portion 10 and a pulse generating circuit 3 is arranged in the second portion 20.

[0078] Alternatively, as shown in FIG. 10, the circuit board includes a first circuit board PCB1 and a second circuit board PCB2, the drive circuit 2 is provided on the first circuit board PCB1, and the pulse generating circuit 3 is provided on the second circuit board PCB2.

[0079] By fabricating the driver circuit 2 and the pulse generator circuit 3 in different parts of the circuit board PCB or on different circuit boards, the pulse generator circuit 3 and the driver circuit 2 can be separated as much as possible. This design is because alternating the wiring of the driver circuit 2 and the wiring of the pulse generator circuit 3 increases strong electromagnetic coupling and parasitic parameters between electronic elements, causing significant interference in the driver circuit 2 and distorting the signal in the driver circuit 2, degrading the quality of the pulse waveform generated in the main circuit. By separating the pulse generator circuit 3 from the driver circuit 2, the interference of the pulse generator circuit 3 with the driver circuit 2 can be significantly reduced.

[0080] 11, the pulse generator of this embodiment further includes a shield structure M connected to the circuit board PCB, and the drive circuit 2 is disposed within the shield structure M. Specifically, the shield structure M is a metal shield, and the metal shield is fixed to the circuit board PCB so that the electro-optical conversion module 21 is located within the metal shield, or the metal shield is fixed to the first circuit board PCB so that the electro-optical conversion module 21 is located within the metal shield.

[0081] As shown in Figures 12 and 13, in the conventional device where the shielding structure M was not provided, the waveform distortion phenomenon occurred in the pulse signal generated by the pulse generating circuit 3. However, in the device pulse generator according to this embodiment, after the shielding structure M is provided, the waveform distortion phenomenon in the pulse signal generated by the pulse generating circuit 3 is significantly improved.

[0082] Based on the same inventive idea, according to an embodiment of the present invention, as shown in Figure 1, a synergy pulse generating device is provided, which includes a host machine 1 and a synergy pulse generating device in the above-mentioned embodiment, and the host machine 1 is configured to generate a first control signal and a second control signal based on an input command.

[0083] The synergy pulse generating device according to this embodiment includes the effects of the synergy pulse generating circuit 3 of the above-described embodiment, and therefore a description thereof will be omitted.

[0084] Specifically, the host machine 1 may be a computer, and the input command may be parameters of the first control signal and the second control signal, such as the voltage, period, and active level time length of the first control signal and the second control signal. The input command may be parameters of the first drive signal and the second drive signal, such as the voltage, period, and pulse width of the first drive signal and the second drive signal.

[0085] When the synergistic pulse generating device according to this embodiment is an electrical ablation device capable of cooperatively outputting microsecond / millisecond pulse signals and nanosecond pulse signals as proposed in the present invention, the first pulse signal is a microsecond pulse signal or a millisecond pulse signal, and the second pulse signal is a nanosecond pulse signal. In this case, the input command may be the required pulse width, number, voltage, etc., or may be a parameter of the tumor tissue. The correspondence between the tumor tissue parameters and the required pulse parameters is stored in the electrical ablation device, and a combination of nanosecond pulses and microsecond / millisecond pulses generated based on the tumor tissue parameters is applied to the tumor tissue, thereby effectively improving the ablation effect of the tumor tissue.

[0086] Based on the same inventive idea, an embodiment of the present invention further provides a synergy pulse generation method, as shown in FIG. 1 and FIG.

[0087] In step S1, the first pulse generating module 31 stores power supplied from a first power supply, and the second pulse generating module 32 stores power supplied from a second power supply. Note that the charging process for the first pulse generating module 31 and the charging process for the second pulse generating module 32 may be performed simultaneously, or only the first pulse generating module 31 or the second pulse generating module 32 may be charged, or the charging process for the first pulse generating module 31 and the charging process for the second pulse generating module 32 may not be performed simultaneously.

[0088] In step S2, the drive circuit 2 receives a first control signal transmitted from the host device 1 and converts the first control signal into a first drive signal. The drive circuit 2 receives a second control signal transmitted from the host device 1 and converts the second control signal into a second drive signal.

[0089] In step S3, the first pulse generating module 31 receives the first drive signal and discharges under the control of the first drive signal to form a first pulse signal to be applied to the load 4. The second pulse generating module 32 receives the second drive signal and discharges under the control of the second drive signal to form a second pulse signal to be applied to the load 4.

[0090] However, in some embodiments, the voltage of the second power supply is greater than the voltage of the first power supply, the width of the second pulse signal is smaller than the width of the first pulse signal, and the time when the second pulse-generating module 32 receives the second drive signal is different from the time when the first pulse-generating module 31 receives the first drive signal.

[0091] In the synergy pulse generation method according to this embodiment, a first control signal and a second control signal transmitted from a host device 1 are converted into a first drive signal and a second drive signal by a drive circuit 2, respectively. A pulse generation circuit 3 selectively generates a first pulse signal and / or a second pulse signal having different widths based on the first drive signal and the second drive signal, thereby realizing the purpose of applying a composite pulse signal to a load 4, for example, a tumor cell. The action of the composite pulse is advantageous in improving the ablation effect on tumor cells.

[0092] 2, an n-th (n is an integer of 1 or more) stage first pulse generating unit 311 included in first pulse generating module 31 receives and stores the amount of power supplied from first power supply U1, and an m-th (m is an integer of 1 or more) stage second pulse generating unit 321 included in second pulse generating module 32 receives and stores the amount of power supplied from second power supply U2. Thus, step S1 includes turning off each first switch unit 3112 when receiving a third drive signal, connecting first storage unit 3111 of each stage in parallel to first power supply U1 to receive and store the amount of power supplied from first power supply U1, and turning off each second switch unit 3212 when receiving a fourth drive signal, connecting second storage unit 3211 of each stage in parallel to second power supply U2 to receive and store the amount of power supplied from second power supply U2.

[0093] Taking the synergy pulse generating circuit 3 shown in Figure 6 as an example, the charging process of the first pulse generating module 31 is as follows: 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 , and a solid-state switching element S 1-4 receives a third drive signal, the solid-state switch element S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 and solid-state switch element S 1-4 are both in the off state, and diode D 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 , diode D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 has a one-way conduction function. 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4are in a parallel relationship and are electrically connected to the first end and the second end of the first power supply U1, i.e., are both electrically connected to the positive and negative terminals of the first power supply U1. 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 The first pulse generating module 31 is charging until the potential difference between both ends of the first pulse generating module 31 becomes the first voltage.

[0094] Taking the synergy pulse generating circuit 3 shown in Figure 6 as an example, the charging process of the second pulse generating module 32 is as follows: 2-1 , solid-state switching element S 2-2 , solid-state switching element S 2-3 and solid-state switch element S 2-4 receives a fourth drive signal, the solid-state switch element S 2-1 , solid-state switching element S 2-2 , solid-state switching element S 2-3 and solid-state switch element S 2-4 are both in the off state, and diode D 3-1 , diode D 3-2 , diode D 3-3 , diode D 3-4 , diode D 4-1 , diode D 4-2 , diode D 4-3 and diode D 4-4 has a one-way conduction function. 2-1 , capacitor C 2-2 , capacitor C 2-3 , and capacitor C 2-4 are in a parallel relationship and electrically connected to the first end and the second end of the second power supply 112, i.e., both are electrically connected to the positive and negative terminals of the second power supply U2. 2-1 , capacitor C 2-2 , capacitor C 2-3 and capacitor C 2-4 The second pulse generating module 32 charges until the potential difference across both ends of the

[0095] In a specific embodiment, the first and second drive signals are both high, while the third and fourth drive signals are both low. That is, unless the first pulse-generating module 31 receives the first drive signal, the first power supply U1 maintains the first capacitance of each stage charged, or the voltage difference across the first capacitance of each stage equals a first voltage. Similarly, unless the second pulse-generating module 32 receives the second drive signal, the second power supply 122 maintains the second capacitance of each stage charged, or the voltage difference across the second capacitance of each stage equals a second voltage. Of course, those skilled in the art should understand that the levels of each drive signal can be adaptively set according to the selection of different solid-state switching elements.

[0096] Alternatively, as shown in FIGS. 8 and 15, in the synergy pulse generating method according to this embodiment, step S2 includes S201 and S202.

[0097] In step S201, the electrical-optical conversion module 21 receives a first control signal and a second control signal, converts the first control signal into a first driving optical signal, converts the second control signal into a second driving optical signal, and transmits the first driving optical signal and the second driving optical signal to the signal processing module 23 via the optical fiber 22.

[0098] In step S202, the signal processing module 23 receives the first optical drive signal and the second optical drive signal, converts the first optical drive signal into a first electrical drive signal, converts the second optical drive signal into a second electrical drive signal, processes the first electrical drive signal to obtain the first drive signal, processes the second electrical drive signal to obtain the second drive signal, transmits the first drive signal to the first pulse generating module 31, and transmits the second drive signal to the second pulse generating module 32.

[0099] In the synergy pulse generation method according to this embodiment, a control signal is converted into an optical drive signal. The optical drive signal is then photoelectrically converted and processed to obtain a drive signal that isolates the weak current circuit from the strong current pulse generation circuit 3. This reduces electromagnetic interference from the pulse generation circuit 3 to the weak current circuit, improving the accuracy of the drive signal and the precision of the pulse signal.

[0100] Alternatively, as shown in FIGS. 2 and 16, in the synergy pulse generating method according to this embodiment, step S3 includes S301, S302, and S303.

[0101] In step S301, the x first pulse generating units 311 receive the first driving signals and generate first pulse signals by discharging under the control of the first driving signals.

[0102] As shown in Figure 7, the solid-state switch element S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 , and a solid-state switching element S 1-4 When any of the solid-state switch elements S receives a first switching signal, 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 and solid-state switch element S 1-4 are both on, and diode D 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 , diode D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 has a one-way conduction function. 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 are in a series relationship, and the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4discharge simultaneously. Since the discharge voltages are both the first voltage, the voltage of the formed pulse is four times the first voltage.

[0103] In step S302, the y second pulse generating units 321 receive the second drive signals and generate second pulse signals by discharging under the control of the second drive signals.

[0104] As shown in Figure 7, the solid-state switch element S 2-1 , solid-state switching element S 2-2 , solid-state switching element S 2-3 , and a solid-state switching element S 2-4 When each of the solid-state switch elements S receives a second control signal, 2-1 , solid-state switch element S 2-2 , solid-state switch element S 2-3 and solid-state switch element S 2-4 are both in the on state. 2-1 , capacitor C 2-2 , capacitor C 2-3 and capacitor C 2-4 are in a series relationship, and the capacitor C 2-1 , capacitor C 2-2 , capacitor C 2-3 and capacitor C 2-4 are discharged at the same time. Since the discharge voltages are both the second voltage, the voltage of the second pulse formed is four times the second voltage.

[0105] In step S303, the first pulse signal and / or the second pulse signal is applied to the load 4.

[0106] In some preferred embodiments, based on the synergy pulse generator including the output module 7, as shown in FIG. 4, step S303 specifically includes applying the first pulse and / or the second pulse to the load 4 under the control of the trigger command. Specifically, the output module 7 can be described by reference to the above-mentioned embodiment of the synergy pulse generator, and therefore the description thereof will be omitted.

[0107] In some preferred embodiments, as shown in FIG. 4 , based on the synergy pulse generator including the resistor 8 and the monitor module 9 described above, the synergy pulse generating method according to this embodiment further includes applying a first pulse signal and / or a second pulse signal to the resistor 8, and simultaneously monitoring the current and voltage applied to the resistor 8 by the first pulse signal and / or the second pulse signal. Specifically, the resistor 8 and the monitor module 9 can be referred to in the embodiment of the synergy pulse generator described above, and therefore, a detailed description thereof will be omitted.

[0108] 4, based on the synergy pulse generator including the first ground-fault module 5 and the first ground-fault module 6 described above, the synergy pulse generating method according to this embodiment further includes receiving a first ground-fault signal and controlling the first ground-fault signal to connect the first pulse generating module 31 to ground to discharge remaining energy in the first pulse generating module 31, and receiving a second ground-fault signal and controlling the second ground-fault signal to connect the second pulse generating module 32 to ground to discharge remaining energy in the second pulse generating module 32. Specifically, the first ground-fault module 5 and the first ground-fault module 6 are described in the synergy pulse generator embodiment described above, and therefore will not be described here.

[0109] By applying the embodiments of the present invention, at least the following effects can be achieved. In the synergy pulse generating apparatus, device, and generating method according to the embodiments of the present invention, a first control signal and a second control signal transmitted from a host machine are converted into a first drive signal and a second drive signal, respectively, by a drive circuit. The pulse generating circuit can selectively form a first pulse signal and / or a second pulse signal having different widths based on the first drive signal and the second drive signal. This achieves the purpose of applying a composite pulse signal to a load. For example, if the load is tumor cells, the role of the composite pulse is advantageous in enhancing the ablation effect on the tumor cells.

[0110] The terms "first" and "second" are merely descriptive and are not intended to indicate or suggest relative importance or the number of technical features that are presented. Therefore, a feature qualified by "first" or "second" may explicitly or implicitly include one or more features. In the description of this invention, "plurality" means two or more unless otherwise specified.

[0111] In the description of the present invention, the terms "mounted," "connected," and "coupled" should be understood in a broad sense unless otherwise clearly specified or limited, and may mean, for example, a fixed connection, a detachable connection, an integral connection, a direct connection, an indirect connection via an intermediate medium, or internal communication between two elements. The specific meanings of the above terms in the present invention will be specifically understood by those skilled in the art.

[0112] In the description herein, the particular features, structures, materials, or characteristics may be combined as appropriate in any one or more embodiments or examples.

[0113] It should be pointed out that the above are only some examples of the present invention, and those skilled in the art may make some improvements and modifications without departing from the principles of the present invention. [Explanation of symbols]

[0114] 1...High-end machine 2...Drive circuit 21...Electro-optical conversion module 22...Optical fiber 23...Signal processing module 3...Pulse generation circuit 31...First pulse generating module 311...first pulse generating unit 3111...First memory unit 3112...First switch section 3113...First off section 32...Second pulse generating unit 321...second pulse generating unit 3211...Second memory section 3212...Second switch section 3213...Second off section 4. Load 5...First leakage current module 6...Second earth leakage module 7...Output module 71...Trigger section 72...Electrode 73...Trigger switch 74...Multiplex conversion unit 8...Resistance 9...Monitor module 91...First monitor section 92...Second monitor section U1: First power supply U2: Second power supply M...Shield structure PCB...circuit board 10...First part 20...Second part PCB1: First circuit board PCB2: Second circuit board

Claims

1. A synergy pulse generator for generating a pulse signal under the control of a host machine, a drive circuit electrically connected to the host machine, receiving a first control signal transmitted from the host machine and converting the first control signal into a first drive signal, and receiving a second control signal transmitted from the host machine and converting the second control signal into a second drive signal; a pulse generation circuit including a first power source, a first pulse generation module electrically connected to the first power source, a second power source, and a second pulse generation module electrically connected to the second power source; the first pulse generation module is configured to store power provided by the first power source and discharge it under control of the first drive signal to form a first pulse signal applied to a load; the second pulse generation module is configured to store power provided by the second power source and discharge it under control of the second drive signal to form a second pulse signal applied to the load; a voltage of the second power supply is greater than a voltage of the first power supply, and a width of the second pulse signal is smaller than a width of the first pulse signal; The driving circuit includes an electrical-optical conversion module, a signal processing module, and a transmission structure electrically connected thereto; the electro-optical conversion module is electrically connected to the host device, and the signal processing module is electrically connected to the pulse generating circuit; the electrical-optical conversion module is configured to receive a control signal transmitted from the host device, convert the control signal into a driving optical signal, and transmit the driving optical signal to the signal processing module via the transmission structure; the signal processing module is configured to receive the optical drive signal, convert the optical drive signal into an electrical drive signal, process the electrical drive signal to obtain a drive signal, and send the drive signal to the pulse generation circuit; The signal processing module further comprises: a second conversion unit coupled to the transmission structure and configured to receive the optical drive signal and convert the optical drive signal into the electrical drive signal; a second signal amplifier unit electrically connected to the second conversion unit and configured to amplify the driving electrical signal to obtain the driving signal; a first filter unit electrically connected to the second conversion unit and the second signal amplification unit, respectively, and configured to perform a first filtering process on the driving electrical signal; a second filter section electrically connected to the second signal amplifier section and the pulse generating circuit, respectively, configured to perform second filtering on the drive signal and transmit the filtered drive signal to the pulse generating circuit; In a configuration comprising: removing high-frequency interference by the first filtering process and the second filtering process to reduce the effect of electromagnetic interference on the first drive signal and the second drive signal; The first pulse signal and the second pulse signal are applied to a load, and the first pulse signal and the second pulse signal having different widths are combined. A synergy pulse generator characterized by:

2. a first earth-fault module electrically connected to the first pulse generating module and a ground, and configured to conduct the first pulse generating module and the ground under control of a first earth-fault signal so as to discharge residual power in the first pulse generating module; and a second earth-fault module electrically connected to the second pulse generating module and to a ground, the second earth-fault module being configured to conduct the second pulse generating module and the ground under control of a second earth-fault signal so as to discharge residual power in the second pulse generating module. The synergy pulse generator according to claim 1 .

3. an output module including a trigger unit and at least one pair of electrodes electrically connected to the trigger unit; the trigger unit is electrically connected to the first pulse generating module and the second pulse generating module, the electrode is in contact with the load; The trigger unit is configured to turn on the first pulse signal and / or the second pulse signal to be transmitted to the electrode when triggered by a trigger command. The synergy pulse generator according to claim 1 .

4. a resistor electrically connected to the first pulse generating module, the second pulse generating module, and a ground, and to which the first pulse signal and / or the second pulse signal is further applied; a monitor module including a first monitor configured to monitor a current from the first pulse signal and the second pulse signal, and a second monitor configured to monitor a voltage applied to the resistor by the first pulse signal and the second pulse signal. The synergy pulse generator according to claim 1 .

5. Further equipped with a circuit board, the circuit board has a first portion on which the drive circuit is provided and a second portion on which the pulse generating circuit is provided and located on the first portion side; The circuit board includes a first circuit board on which the drive circuit is provided and a second circuit board on which the pulse generating circuit is provided. The synergy pulse generator according to claim 1 .

6. a shield structure provided on the circuit board, the shield structure having the drive circuit therein; The synergy pulse generator according to claim 5.

7. the first pulse signal is a microsecond pulse signal or a millisecond pulse signal; the second pulse signal is a nanosecond pulse signal; The synergy pulse generator according to claim 1 .

8. The electro-optical conversion module comprises: a buffer unit electrically connected to the host device and configured to receive and buffer the control signal; a first signal amplifier unit electrically connected to the buffer unit and configured to perform an amplification process on the buffered control signal; a first conversion unit electrically connected to the first signal amplification unit and the transmission structure, and configured to perform electro-optical conversion on the amplified control signal to obtain a driving optical signal and transmit the driving optical signal to the signal processing module via the transmission structure; The synergy pulse generator according to claim 1 .

9. the buffer unit is a multi-buffer including k signal buffer channels (k is an integer greater than 1); Each of the multi-buffers receives one of the control signals and stores the control signal; The first signal amplifier unit includes k first amplifier subunits, each electrically connected to one of the signal buffer channels, and the first amplifier subunits amplify the control signals stored in the corresponding signal buffer channels, the first conversion unit is an optical signal transmitter having k electrical-to-optical conversion channels; Each of the electrical-optical conversion channels is electrically connected to one of the first amplification sub-units, and the electrical-optical conversion channel converts the control signal amplified by the corresponding first amplification sub-unit into the driving optical signal, and the driving optical signal is transmitted to a signal processing module via a transmission structure. The synergy pulse generator according to claim 8.

10. the second conversion unit is an optical signal receiver having k opto-electrical conversion channels (k is an integer greater than 1), each of the opto-electrical conversion channels being for receiving one of the optical drive signals and converting the optical drive signal into the electrical drive signal; the first filter unit includes k first filter subunits, each electrically connected to one of the photoelectric conversion channels, and the first filter subunits perform a first filtering process on a driving electrical signal obtained by converting the corresponding photoelectric conversion channel; the second signal amplifier unit includes k second amplifier subunits, each of which is electrically connected to one of the first filter subunits, and the second amplifier subunits amplify the first filtered driving electrical signal by the corresponding first filter subunit to obtain the driving signal; The second filter section includes k second filter subsections, each of which is electrically connected to one of the second amplification subsections, and the second filter subsection performs second filtering on the drive signal obtained by amplification processing in the corresponding second amplification subsection, and transmits the drive signal after second filtering to the pulse generation circuit. The synergy pulse generator according to claim 1 .

11. the first pulse generating module includes n (n is an integer of 1 or more) stages of first pulse generating units, each of which is configured to receive and store power supplied at a first voltage from the first power supply, and discharge the stored power when receiving a first control signal, such that x (x is an integer of 1 or more and n or less) first pulse generating units that receive the first control signal discharge the stored power to form the first pulse signal to be applied to a load; the second pulse generating module includes m (m is an integer of 1 or more) stages of second pulse generating units, each of which is configured to receive and store power supplied at a second voltage from the second power supply, and discharge the stored power when receiving a second control signal, such that y (y is an integer of 1 or more and n or less) second pulse generating units that receive the second control signal discharge the stored power to form the second pulse signal to be applied to a load; the second voltage is greater than the first voltage; The synergy pulse generator according to claim 1 .

12. the first pulse generating unit includes a first storage unit, a first switch unit, and a first off unit; the first switch unit receives the first control signal, and is turned on under control of the first control signal, thereby discharging the first storage units connected in series at the same stage as the first switch unit that receives the first control signal, in order to form the first pulse signal; the first off section is configured such that only a charging current flows from the first power supply to the first pulse generating section, or such that a charging current flows from the first pulse generating section of a current stage to the first pulse generating section of a next stage, and such that only a discharging current flows from the first pulse generating section of a current stage to the first pulse generating section of a next stage, the second pulse generating unit includes a second storage unit, a second switch unit, and a second off unit; the second switch unit receives the second control signal, and is turned on under control of the second control signal, thereby discharging the second storage units connected in series at the same stage as the second switch unit that receives the second control signal, in order to form the second pulse signal; The second off section is configured so that only a charging current flows from the second power supply to the second pulse generating section, or so that a charging current flows from the second pulse generating section of the current stage to the second pulse generating section of the next stage, and so that only a discharging current flows from the second pulse generating section of the current stage to the second pulse generating section of the next stage. The synergy pulse generator according to claim 11.

13. the first off unit includes a first off element and a second off element, a first off element in a first stage electrically connected to a first end of the first power supply and a first end of a first storage unit in a first stage; The first off element in the i-th stage (i is an integer of 2 or more) is electrically connected to the first end of the first memory unit in the i-1-th stage, the first end of the first memory unit in the i-1-th stage, and the first off element in the i-1-th stage, the second off element of each stage is electrically connected to the second end of the first memory unit of the stage, the second end of the first switch unit of the stage, and the second off element of the next stage, the second off unit includes a third off element and a fourth off element, the third off element of the first stage is electrically connected to a first end of the second power supply and a first end of the second memory unit of the first stage, The third off element in the j-th stage (j is an integer of 2 or more) is electrically connected to the first end of the second memory unit in the j-1-th stage, the first end of the second memory unit in the j-1-th stage, and the third off element in the j-1-th stage, the fourth off element of each stage is electrically connected to the second end of the second memory unit of the stage, the second end of the second switch unit of the stage, and the fourth off element of the next stage, The synergy pulse generator according to claim 12.

14. both ends of the first memory unit of each stage are electrically connected to both ends of the first power supply, a control end of the first switch unit of each stage is configured to receive the first control signal, and a first end and a second end of the first switch unit of each stage are electrically connected to a first end of the first memory unit of the current stage and a second end of the first memory unit of a next stage, Both ends of the second storage unit of each stage are electrically connected to both ends of the second power supply, respectively, and a control end of the second switch unit of each stage is configured to receive the second control signal, and a first end and a second end of the second switch unit of each stage are electrically connected to a first end of the second storage unit of the current stage and a second end of the second storage unit of the next stage, respectively. The synergy pulse generator according to claim 12.

15. the first storage unit has a first capacity, and the second storage unit has a second capacity; the first switch section includes a first solid-state switch element, and the second switch section includes a second solid-state switch element; The first off element includes a first diode, the second off element includes a second diode, the third off element includes a third diode, and the fourth off element includes a fourth diode. The synergy pulse generator of claim 13.

16. a host machine that generates a first control signal and a second control signal in response to an input command; A synergy pulse generator according to any one of claims 1 to 15, Synergy pulse generating device.

17. the synergy pulse generating device is an electrical ablation device; the first pulse signal generated by the synergy pulse generator is a microsecond pulse signal or a millisecond pulse signal; The second pulse signal generated by the synergy pulse generator is a nanosecond pulse signal.

17. The synergistic pulse generating device of claim 16.

18. A synergistic pulse generating method for the synergistic pulse generating device according to any one of claims 1 to 15, comprising: the first pulse generating module stores power supplied from the first power supply, and the second pulse generating module stores power supplied from the second power supply; The drive circuit receives a first control signal transmitted by a host machine and converts the first control signal into a first drive signal, and the drive circuit receives a second control signal transmitted by the host machine and converts the second control signal into a second drive signal; a first pulse generating module receiving the first drive signal to form a first pulse signal to be applied to a load and discharging under control of the first drive signal; and a second pulse generating module receiving the second drive signal to form a second pulse signal to be applied to the load and discharging under control of the second drive signal; In a configuration in which the voltage of the second power supply is higher than the voltage of the first power supply and the width of the second pulse signal is smaller than the width of the first pulse signal, When the drive circuit converts the first drive signal, the driving circuit includes an electrical-to-optical conversion module that receives the first control signal, converts the first control signal into a first driving optical signal, and transmits the first driving optical signal to a second conversion unit through a transmission structure; the second conversion unit receives the first optical drive signal and converts it into a first electrical drive signal; the first filter unit performs a first filtering process on the first driving electrical signal; the second signal amplifier performs an amplification process on the first driving electrical signal that has been subjected to the first filtering process to obtain a third driving signal; the second filter unit performs second filtering on the third drive signal and transmits the third drive signal that has been subjected to the second filtering to the pulse generating circuit as a first drive signal; and, When the drive circuit converts the second drive signal, the electrical-optical conversion module receives the second control signal, converts it into a second driving optical signal, and transmits it to the second conversion unit through a transmission structure; the second conversion unit receives the second optical drive signal and converts it into a second electrical drive signal; the first filter unit performs a first filtering process on the second driving electrical signal; the second signal amplifier performs an amplification process on the second driving electrical signal that has been subjected to the first filtering process to obtain a fourth driving signal; the second filter unit performs second filtering on the fourth drive signal and transmits the fourth drive signal that has been subjected to the second filtering to the pulse generating circuit as a second drive signal; Including, removing high-frequency interference by the first filtering process and the second filtering process to reduce the effect of electromagnetic interference on the first drive signal and the second drive signal; The first pulse signal and the second pulse signal are applied to a load, and the first pulse signal and the second pulse signal having different widths are combined. A synergy pulse generating method.

19. The time at which the second pulse generating module receives the second drive signal is different from the time at which the first pulse generating module receives the first drive signal.

20. The synergistic pulse generation method of claim 18.

20. receiving a first earth fault signal and conducting the first pulse generating module to ground under control of the first earth fault signal to discharge residual power in the first pulse generating module; receiving a second earth leakage signal and conducting the second pulse generating module to ground under control of the second earth leakage signal to discharge residual power in the second pulse generating module; 20. The synergistic pulse generation method of claim 18.

21. The application of the first pulse signal and / or the second pulse signal to a load may include: and applying the first pulse signal and / or the second pulse signal to the load under control of a trigger command.

20. The synergistic pulse generation method of claim 18.

22. The method further includes monitoring a current and / or a voltage output by the first pulse signal and / or the second pulse signal.

20. The synergistic pulse generation method of claim 18.

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