Self-tanning composition containing aromatic sulfonate and method thereof

Abstract

(A) reducing sugar, (B) 100 Å 2 A topical skin care composition comprising (C) an aromatic sulfonate having a topological polar surface area (tPSA) of less than 1000 nm, and (D) a carrier. A method for adjusting skin color appearance (e.g., hue angle, value, saturation) is also disclosed, comprising applying the topical skin care composition to skin. When applied to skin, the topical skin care composition can provide deep, rich, long-lasting sunless tanning with an aesthetically pleasing red / bronze hue.

Description

[Technical Field]

[0001] The present invention relates to topical skincare compositions, particularly topical skincare compositions comprising (A) reducing sugars, (B) aromatic sulfonates, and (C) a carrier, and to a method of self-tanning using a topical skincare composition. [Background technology]

[0002] The “Background Art” provided herein is generally intended to present the background of the present invention. To the extent described in this Background Art section and to the extent of aspects of description that are not eligible as prior art at the time of filing, the inventors’ work is not explicitly or implicitly recognized as prior art to the present invention.

[0003] Consumers worldwide enjoy spending time in the sun for a variety of reasons, including outdoor recreation, sports, and tanning (darkening of the skin). Unfortunately, exposure to UV radiation is known to potentially promote skin cancer. Furthermore, partial exposure to UV radiation can lead to uneven skin tone across the entire body. Therefore, there is a health and aesthetic motivation to seek alternatives that can achieve a natural look and even skin tone while avoiding the risks of sun exposure.

[0004] Despite known risks, sunbathing remains the most common method of darkening skin in the US and EU. Sunless tanning agents and glow moisturizers are also common methods, but many consumers are dissatisfied with these products, often due to unnatural colors, insufficient darkening, or rapid fading. For example, many conventional self-tanning products that use dihydroxyacetone (DHA) as a tanning agent produce an undesirable orange hue. In addition to darkening the skin, effective hue adjustment is needed to create a distinctive tan with a bronze / red tint.

[0005] Several skin tanning compositions have been reported that utilize azole compounds, pigments (e.g., carmine), crosslinked cationic copolymers, and vanillin polymers to enhance skin coloring (U.S. Patent Nos. 5,705,145, 6,214,322, 7,780,954, and 7,935,331, each of which is incorporated herein by reference in its entirety). However, there remains a need for improved compositions that can effectively darken the color of the skin and shift the skin's hue. SUMMARY OF THE INVENTION PROBLEMS TO BE SOLVED BY THE INVENTION

[0006] As described above, there is a need for long-lasting topical skin care compositions that produce a deeper color and a more prominent bronze / red hue

[0007] Thus, one object of the present invention is to provide a novel topical skin care composition that meets these criteria.

[0008] Another object of the present invention is to provide a novel method for adjusting the appearance of the color of a subject's skin (e.g., lightness, hue angle, chroma) by topically applying a topical skin care composition to the subject's skin. MEANS FOR SOLVING THE PROBLEMS

[0009] These and other objects, which will become apparent in the following detailed description, are unexpectedly achieved by the inventors' discovery that a topical skin care composition promoting a long-lasting, rich and intense (i.e., dark) tanning color characterized by a desired bronze / red hue can be obtained by a combination of a reducing sugar, an aromatic sulfonate, and a carrier.

[0010] Thus, the present invention provides the following. (1) (A) A reducing sugar of about 0.1 to 30% by weight based on the total weight of the topical skin care composition, (B) Alkali metal salts of aromatic sulfonic acids, (C) Carrier A topical skincare composition comprising, Alkali metal aromatic sulfonate (B) at 100 Å 2 Having a topological polar surface area (tPSA) of less than, The weight ratio ((B):(A)) of alkali metal aromatic sulfonate salt (B) to reducing sugar (A) is 1:20 to 20:1. Topical skincare composition.

[0011] (2) The topical skincare composition according to (1), wherein the alkali metal salt of aromatic sulfonate (B) is optionally substituted phenyl sulfonate, optionally substituted naphthyl sulfonate, or both.

[0012] (3) The topical skincare composition according to (1) or (2), wherein the alkali metal aromatic sulfonate salt (B) has 2 or fewer hydrogen bond donating sites.

[0013] (4) The topical skin care composition according to any one of (1) to (3), wherein the alkali metal salt of aromatic sulfonate (B) is sodium 2-naphthalene sulfonate.

[0014] (5) The topical skin care composition according to any one of (1) to (3), wherein the alkali metal salt of aromatic sulfonate (B) is sodium p-toluenesulfonate.

[0015] (6) The topical skin care composition according to any one of (1) to (3), wherein the alkali metal salt of aromatic sulfonate (B) is sodium cumenesulfonate.

[0016] (7) The topical skin care composition according to any one of (1) to (6), wherein the reducing sugar (A) is dihydroxyacetone, erythrolose, or both.

[0017] (8) A topical skincare composition according to any one of (1) to (7), wherein the carrier (C) contains an aromatic alcohol.

[0018] (9) A topical skincare composition according to any one of (1) to (8), wherein the carrier (C) contains benzyl alcohol.

[0019] (10)(D) A topical skin care composition according to any one of (1) to (9), further comprising an organic solvent.

[0020] (11) The topical skin care composition according to (10), wherein the organic solvent (D) comprises a polyol.

[0021] (12) The topical skincare composition according to (11), wherein the polyol is at least one selected from the group consisting of 1,3-propanediol, 1,2-propanediol, ethylene glycol, glycerin, and 1,3-butanediol.

[0022] (13) A topical skin care composition according to any one of (10) to (12), wherein the weight ratio ((C):(D)) of the carrier (C) to the organic solvent (D) is 1:20 to 1:2.

[0023] (14) A topical skin care composition according to any one of (1) to (13), wherein the weight ratio ((B):(C)) of the alkali metal aromatic sulfonate salt (B) to the support (C) is 1:4 to 4:1.

[0024] (15) A topical skincare composition according to any one of (1) to (14), which is substantially free of cationic copolymers.

[0025] (16) A topical skincare composition according to any one of (1) to (15), which is in the form of a lotion, cream, gel, spray, or foam.

[0026] (17) A method for adjusting the skin color of a subject, (1) to (16) is a step of applying a topical skincare composition described in any one of the above to the target skin topically. Includes, Local application results in a decrease or increase of at least 0.5° in the h° h of the color compared to before local application. method.

[0027] (18) A method for adjusting the skin color of a subject, (1) to (16) is a step of applying a topical skincare composition described in any one of the above to the target skin topically. Includes, Local application results in a change in the brightness L of each color compared to before local application. * The color decreases by at least 10%, and the h° h of the color decreases or increases by at least 0.5°. method.

[0028] (19) The method according to (18), wherein the topical skin care composition is applied topically to a subject 1 to 3 times a day for 1 to 7 consecutive days.

[0029] (20) A method for adjusting the color saturation of the target skin, (1) to (16) is a step of applying a topical skincare composition described in any one of the above to the target skin topically. Includes, Local application reduces the color saturation C compared to before local application. * It will increase by at least 10%. method.

[0030] (21) The method according to (20), wherein the topical skin care composition is applied topically to a subject 1 to 3 times a day for 1 to 7 consecutive days.

[0031] (22) A collection of topical skin care products for retail sale, (a)(A) Reducing sugars in an amount of approximately 0.1 to 30% by weight relative to the total weight of the topical skin care composition. (B) Alkali metal salts of aromatic sulfonic acids, (C) Carrier Includes, Alkali metal aromatic sulfonate (B) at 100 Å 2 Having a topological polar surface area (tPSA) of less than, The weight ratio ((B):(A)) of alkali metal aromatic sulfonate salt (B) to reducing sugar (A) is 1:20 to 20:1. A first topical skincare composition, (b) (A) Reducing sugars in an amount of approximately 0.1 to 30% by weight relative to the total weight of the topical skin care composition. (B) Alkali metal salts of aromatic sulfonic acids, (C) Carrier Includes, Alkali metal aromatic sulfonate (B) at 100 Å 2 Having a topological polar surface area (tPSA) of less than, The weight ratio ((B):(A)) of alkali metal aromatic sulfonate salt (B) to reducing sugar (A) is 1:20 to 20:1. A second topical skincare composition, Includes, The amount of reducing sugar (A) present in the first topical skincare composition (a) is less than the amount of reducing sugar (A) present in the second skincare composition (b), and the amounts are, in each case, relative to the total weight of the first and second topical skincare compositions. collection.

[0032] (23) The collection according to (22), wherein the first topical skin care composition (a) and the second topical skin care composition (b) are packaged separately.

[0033] (24)(A) Reducing sugars in an amount of approximately 0.1 to 30% by weight relative to the total weight of the topical skin care composition. (B) Alkali metal salts of aromatic sulfonic acids, (C) Carrier A topical skincare composition comprising, Alkali metal aromatic sulfonate (B) at 100 Å 2 Having a topological polar surface area (tPSA) of less than, The reducing sugar (A) is dihydroxyacetone, erythrolose, or both. The alkali metal salt of aromatic sulfonic acid (B) is optionally substituted phenylsulfonate, optionally substituted naphthylsulfonate, or both. The carrier (C) contains an aromatic alcohol, The weight ratio ((B):(A)) of alkali metal aromatic sulfonate salt (B) to reducing sugar (A) is 1:20 to 20:1. Topical skincare composition.

[0034] (25)(D) The topical skin care composition according to (24), further comprising an organic solvent.

[0035] (26) The topical skin care composition according to (24), wherein the weight ratio ((B):(C)) of the alkali metal aromatic sulfonate salt (B) to the support (C) is 1:4 to 4:1.

[0036] (27) The topical skincare composition according to (24), which is substantially free of cationic copolymers.

[0037] (28)(A) Reducing sugars in an amount of approximately 0.1 to 10% by weight relative to the total weight of the topical skin care composition. (B) Approximately 0.1 to 10% by weight of an alkali metal aromatic sulfonate relative to the total weight of the topical skin care composition, (C) A carrier comprising approximately 0.1 to 5% by weight relative to the total weight of the topical skin care composition. A topical skincare composition comprising, Alkali metal aromatic sulfonate (B) at 100 Å 2 Having a topological polar surface area (tPSA) of less than, The reducing sugar (A) is dihydroxyacetone, erythrolose, or both. The alkali metal salt of aromatic sulfonic acid (B) is optionally substituted phenylsulfonate, optionally substituted naphthylsulfonate, or both. The carrier (C) contains an aromatic alcohol, The weight ratio of alkali metal aromatic sulfonate salt (B) to reducing sugar (A) is ((B):(A)) 1:5 to 5:1. Topical skincare composition.

[0038] (29)(D) The topical skin care composition according to (28), further comprising an organic solvent.

[0039] (30) The topical skincare composition according to (28), wherein the weight ratio ((B):(C)) of the alkali metal aromatic sulfonate salt (B) to the support (C) is 1:4 to 4:1.

[0040] (31) The topical skincare composition according to (28), which is substantially free of cationic copolymers.

[0041] The preceding paragraphs are provided as a general introduction and do not limit the scope of the following claims. The embodiments described, along with their further advantages, are best understood by referring to the following detailed description.

[0042] This patent or application document includes at least one drawing made in color. Copies of this patent or patent application publication containing the color drawing are available from the Patent Office upon request and payment of the required fees.

[0043] A more complete review of the present invention and many of its associated advantages will be readily apparent as they become better understood by referring to the following detailed description in conjunction with the accompanying drawings. [Brief explanation of the drawing]

[0044] [Figure 1A] These bar graphs show the change in skin darkness (ΔL*) after four applications (once a day for four days) of a control gel containing only 2% by weight of dihydroxyacetone (DHA) ("control") and a prototype gel containing 2% by weight of DHA, 2.5% by weight of sodium 2-naphthalene sulfonate (NSA), and 2.5% by weight of benzyl alcohol (BA) ("prototype"). [Figure 1B]These bar graphs show the change in skin hue angle (Δh°) after four applications (once a day for four days) of a control gel containing 2% by weight of DHA ("control") and a prototype gel containing 2% by weight of DHA, 2.5% by weight of NSA, and 2.5% by weight of BA ("prototype"). [Figure 1C] This is a photograph showing human skin after four applications (once a day for four days) of a control gel containing only 2% by weight of dihydroxyacetone (DHA). [Figure 1D] This is a photograph showing human skin after four applications (once a day for four days) of a prototype gel containing 2% by weight of DHA, 2.5% by weight of sodium 2-naphthalene sulfonate (NSA), and 2.5% by weight of benzyl alcohol (BA). [Figure 2] These bar graphs illustrate the changes in skin darkness 6 hours and 24 hours after application of a control composition containing only DHA ("A"), a topical skincare composition containing DHA and NSA ("B"), and a topical skincare composition containing DHA and sodium p-toluenesulfonate (pTS) ("C"). [Figure 3] These are color-corrected images showing human skin after treatment with a control composition containing only DHA ("Control") (upper right circle), a topical skincare composition containing DHA and NSA ("NSA") (upper left circle), and a topical skincare composition containing DHA and pTS ("pTS") (lower left circle). Color correction was performed using the CASMATCH method (Bear Medic Co.). [Figure 4] These bar graphs show the change in skin darkness (ΔL*) after 3 daily applications (once a day for 3 consecutive days), after 7 daily applications (once a day for 7 consecutive days), and after 3 days of fading following 7 daily applications, respectively, for a control composition containing only DHA ("A") and a topical skincare composition containing DHA, NSA, and BA ("B"). [Figure 5]These bar graphs show the change in skin hue angle Δh° after 3 daily applications (once a day for 3 consecutive days), after 7 daily applications (once a day for 7 consecutive days), and after 3 days of fading following 7 daily applications, respectively, for a control composition containing only DHA ("A") and a topical skincare composition containing DHA, NSA, and BA ("B"). [Figure 6] This is a schematic diagram illustrating the preparation of a protein solid gel model for research. [Figure 7A] This is a photograph showing a protein solid gel after treatment with DHA alone. [Figure 7B] This is a photograph showing a protein solid gel 24 hours after treatment with a mixture of DHA and pTS. [Figure 7C] This is a photograph showing a protein solid gel 24 hours after treatment with a mixture of DHA and NSA. [Figure 7D] These bar graphs show the change in the darkness of the protein solid gel after 24 hours of treatment with DHA alone ("control"), a mixture of DHA and NSA ("NSA"), and a mixture of DHA and pTS ("pTS"). [Figure 8A] This is a photograph showing a protein solid gel 7 hours after application of DHA alone at a temperature of 40°C and pH 5.4. [Figure 8B] This is a photograph showing a protein solid gel 7 hours after application of a mixture of DHA and NSA at a temperature of 40°C and pH 5.4. [Figure 8C] This is a photograph showing a protein solid gel 7 hours after application of a mixture of DHA and pTS at a temperature of 40°C and pH 5.4. [Figure 8D] This is a photograph showing a protein solid gel 7 hours after application of a mixture of DHA and sodium 4-isopropylbenzenesulfonate at a temperature of 40°C and pH 5.4. [Figure 8E] This photograph shows a protein solid gel 7 hours after application of a mixture of DHA and poly(4-styrene sulfonate sodium) at a temperature of 40°C and pH 5.4. [Figure 9]This is a portion of the chromaticity diagram drawn using the CIE L*C*h° and CIE L*a*b* color space models. [Modes for carrying out the invention]

[0045] In the following description, other embodiments may be used, and it should be understood that structural and operational modifications may be made without departing from the scope of the embodiments disclosed herein.

[0046] definition As used herein, words such as “a” and “an” have the meaning of “one or more.”

[0047] Where numerical limits or ranges are described in this specification, the endpoints are included. Furthermore, all values ​​and subranges within a numerical limit or range are specifically included as if they were explicitly described.

[0048] When referring to topical skin care compositions, the phrase “substantially not containing” means, unless otherwise specified, that the amount of any particular ingredient present in the topical skin care composition is less than about 1% by weight, preferably less than about 0.5% by weight, more preferably less than about 0.1% by weight, even more preferably less than about 0.05% by weight, and even more preferably 0% by weight, relative to the total weight of the topical skin care composition.

[0049] As used herein, the term “approximately” may be used to indicate that a value and / or location stated in relation to a size and / or location is within a reasonably expected range of the value and / or location. For example, a number may have a value that is + / -0.1%, + / -1%, + / -2%, + / -5%, or + / -10% of the stated value (or range).

[0050] As used herein, the terms “optional” or “optional” mean that the event described below may or may not occur, or that the component described below may or may not be present (e.g., 0% by weight).

[0051] As used herein, the term “substituted” refers to at least one hydrogen atom that has been replaced by a non-hydrogen group, provided that the normal valence is maintained and the substitution results in a stable compound.

[0052] As used herein, the term "alkyl" refers to a linear, branched, or cyclic aliphatic fragment having at least one, preferably at least two, preferably at least three, preferably at least four carbon atoms and up to 22, preferably up to 20, preferably up to 18, preferably up to 12, preferably up to 8 carbon atoms, unless otherwise specified. Examples of alkyl groups include, but are not limited to, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, pentyl, isopentyl, neopentyl, hexyl, isohexyl, 3-methylpentyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, lauryl, myristyl, cetyl, and stearyl, as well as Guerbet-type alkyl groups (e.g., 2-methylpentyl, 2-ethylhexyl, 2-propylheptyl, 2-butyloctyl, 2-pentylnonyl, 2-hexyldecyl, 2-heptylundecyl, 2-octyldodecyl, 2-nonyltridecyl, 2-decyltetradecyl, and 2-undecylpentadecyl). Cycloalkyl groups are a type of cyclic alkyl group. Examples of cycloalkyl groups include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, norbornyl, and adamantyl.

[0053] As used herein, the term "aryl" refers to an aromatic group containing only carbon atoms in the aromatic ring, such as phenyl, biphenyl, naphthyl, and anthracenyl. Examples of aryls, but not limited to, include phenyl, 4-methylphenyl (p-tolyl), 2-methylphenyl, 3-methylphenyl, 4-isopropylphenyl, 2-isopropylphenyl, 3-isopropylphenyl, 4-dodecylphenyl, 4-vinylphenyl, 1-naphthyl, and 2-naphthyl.

[0054] The term "heteroaryl" is used herein to refer to an aryl group in which at least one carbon atom is replaced by a heteroatom (e.g., nitrogen, oxygen, sulfur), such as indolyl, furanyl, imidazolyl, triazolyl, triazinyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, pyrrolyl, pyrazinyl, tetrazolyl, pyridyl (or its N-oxide), thienyl, pyrimidinyl (or its N-oxide), 1H-indolyl, isoquinolyl (or its N-oxide), or quinolyl (or its N-oxide).

[0055] As used herein, the term "alkoxy" refers to a linear or branched alkyl group bonded to an oxygen atom. Examples of alkoxy groups, but not limited to, include methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, secondary butoxy, tertiary butoxy, pentoxy, isopentoxy, hexyloxy, heptyloxy, octyloxy, nonyloxy, and decyloxy.

[0056] As used herein, the term "alkoxycarbonyl" refers to an alkoxy group bonded to a carbonyl group (i.e., >C=O).

[0057] As used herein, the term "halogen" means fluoro, chloro, bromo, and iodine.

[0058] As used herein, the term “skin” refers to the skin present in humans and other mammals. It is recognized that skin is present in many different parts of the body, and the application of topical skincare compositions herein is not limited to skin found in specific body parts. For example, topical skincare compositions may be applied to any area of ​​skin intended for self-tanning, including the face, limbs, feet, neck, and torso. Furthermore, topical skincare compositions may be applied to the entire body as a moisturizer as part of a daily skincare routine.

[0059] Various topical skincare composition ingredients are listed throughout this specification and are configured according to their primary or most desirable function, benefit, or use. However, the classification of an ingredient under a specific function, benefit, or use does not mean that the ingredient is limited to that function, benefit, or use only. For example, even though benzyl alcohol is listed as a carrier, the usefulness of benzyl alcohol is not limited to its use as a carrier, as benzyl alcohol can also confer other beneficial properties, such as acting as a preservative and / or fragrance.

[0060] Topical skincare composition The present invention relates to a self-tanning topical skincare composition that alters the hue angle, reduces brightness, and increases color saturation of the skin. The topical skincare composition is easy to apply and can be used to darken skin color, shift skin tone, and provide a uniform, long-lasting (fade-resistant) tanning coating.

[0061] Therefore, topical skincare compositions contain ingredients that enable skin tanning, as well as ingredients that reduce skin brightness and shift hue, thereby facilitating the delivery of tanning agents and enabling easy application of the topical skincare composition. Such compositions generally contain the following ingredients: preferably (A) a tanning agent which is a reducing sugar, (B) an aromatic sulfonate, (C) a carrier, and optionally (D) an organic solvent, (E) water, (F) a thickener, (G) a preservative, and (H) an acidulant. In preferred embodiments, all ingredients are compatible with reducing sugars (i.e., they do not react with reducing sugars and do not cause reactions with reducing sugars) and are homogeneously dispersed or uniformly dissolved throughout the topical skincare composition. Surprisingly, by adding ingredients such as aromatic sulfonates (B) and carriers (C) to the reducing sugar (A), for example, skin brightness (L) can be reduced. * In addition to reducing ), it was found that the self-tanning effect of the composition is enhanced by inducing a change in the skin's hue angle (h°).

[0062] Topical skincare compositions may be in the form of a liquid, solution, emulsion, lotion, cream, gel, paste, spray, foam, or any other form suitable for topical application to the skin. Preferably, topical skincare compositions are in the form of a lotion, cream, gel, spray, or foam. More preferably, topical skincare compositions are in the form of a cream or gel that can be applied uniformly.

[0063] Tanning agent To act as an effective self-tanning agent, the topical skincare compositions herein include a “tanning agent” which is any coloring molecule capable of staining the skin when in contact with the skin, or any non-coloring molecule capable of reacting with the skin and coloring the skin, in particular a molecule capable of darkening the skin to an effect similar to the darkening effect achieved by exposure of the skin to sunlight (i.e., natural tanning).

[0064] In preferred embodiments, the tanning agent is (A) a reducing sugar. Certain reducing sugars, such as monosaccharides (e.g., dihydroxyacetone), react with naturally occurring amino acids on the skin surface via the Mailard reaction to form pigmented melanoidins that alter skin color (each in whole is incorporated herein by reference: Bobin et al., J.Soc.Cosmet.Chem., 35, pp. 265-272, 1984; Mailard LC, CRAcad.Sci.154, 66-68, 1912).

[0065] Various amino acids react with various reducing sugars to produce a range of colorations from yellow to brown. Any reducing sugar capable of reacting with amino acids found in the skin (e.g., naturally occurring amino acids) to produce darkened skin can be used as a tanning agent in the present invention. The reducing sugar (A) may be a monosaccharide, such as an aldose having 2 to 6 carbon atoms, preferably 3 to 5 carbon atoms, more preferably 3 to 4 carbon atoms, and even more preferably 3 carbon atoms, or a ketose having 3 to 6 carbon atoms, preferably 4 to 5 carbon atoms, more preferably 3 to 4 carbon atoms, and also includes mixtures of such aldoses and / or ketoses. Exemplary reducing sugars, but not limited to these, include dihydroxyacetone (DHA), erythritolose, glycoaldehyde, glyceraldehyde, meso-tartrate aldehyde, glucose, glucose, xylose, fructose, ribose, arabinose, allose, talose, altrose, idose, mannose, galactose, and erythritolose. In preferred embodiments, the reducing sugar (A) is dihydroxyacetone, erythrolose, or both. Most preferably, the reducing sugar (A) is dihydroxyacetone. Dihydroxyacetone is available, for example, from EMD Millipore.

[0066] The amount of tanning agent present in a topical skincare composition may vary depending on the desired skin coloring (e.g., lightness, hue angle, color saturation), as well as the amount and properties of other components. In some embodiments, the tanning agent is present in an amount of at least about 0.05% by weight, preferably at least about 0.1% by weight, preferably at least about 0.5% by weight, preferably at least about 1% by weight, more preferably at least about 1.5% by weight, even more preferably at least about 1.75% by weight, even more preferably at least about 2% by weight, and up to about 10% by weight, preferably up to about 8% by weight, preferably up to about 6% by weight, preferably up to about 4% by weight, preferably up to about 3.5% by weight, more preferably up to about 3% by weight, even more preferably up to about 2.5% by weight, and even more preferably up to about 2.25% by weight, based on the total weight of the topical skincare composition.

[0067] In a preferred embodiment, the topical skincare composition is substantially free of tanning agents other than reducing sugars, which includes being substantially free of, preferably completely free of (i.e., 0% by weight) synthetic dyes and natural pigments that impart color. Alternatively, the topical skincare composition may contain other tanning agents, such as synthetic dyes and / or natural pigments, in the amounts already listed.

[0068] Examples of synthetic dyes that may be included as tanning agents include, but are not limited to, acid dyes (e.g., Yellow 203 (D&C Yellow 10, color index (CI) 47005 as indicated by CI), Orange 205 (D&C Orange 4, CI 15510), Red 3 (Erythrosine B, CI 45430), Red 94 (Rose Bengal, CI 45440), and Red 227 (D&C Red 33, CI 17200)); and quinone dyes (e.g., anthraquinone, 1-N-methylmorphone). Linium-propylamino-4-hydroxyanthraquine, 1-aminopropylamino-4-methylaminoanthraquinone, 1-aminopropylaminoanthraquinone, 5-β-hydroxyethyl-1,4-diaminoanthraquinone, 2-aminoethylaminoanthraquinone, 1,4-bis(β,γ-dihydroxypropylamino)anthraquinone, Lawson, Juglon, Alizarin, Purpurin, Carminic acid, Carmine, Kermesic acid, Spinulosine, Disperse Red 15, Solvent Violet 13, Disperse Violet 1, Disperse Violet 4, Disperse Blue 1, Disperse Violet 8, Disperse Blue 3, Disperse Red 11, Disperse Blue 7, Basic Blue 22, Disperse Violet 15, Basic Blue 99); Azo dyes (e.g., 1,3-dimethyl-2-[[4-(dimethylamino)phenyl]azo]-1H-imidazolium chloride, 1,3-dimethyl-2-[(4-aminophenyl)azo]-1H-imidazolium chloride, 1-methyl-4-[(methylphenylhydrazono)methyl]pyridinium methyl sulfate, Disperse Red 17, Basic Red 22, Basic Red 76, Basic Yellow 57, Basic Brown 16, Basic Brown 17, Disperse Black 9);and indoamine dyes (e.g., 2-β-hydroxyethylamino-5-[bis(β-4’-hydroxyethyl)amino]anilino-1,4-benzoquinone, 2-β-hydroxyethylamino-5-(2’-methoxy-4’-amino)anilino-1,4-benzoquinone, 3-N-(2’-chloro-4’-hydroxy)phenylacetamino-6-methoxy-1,4-benzoquinoneimine, 3-N-(3’-chloro-4’-methylamino)phenylureido-6-methyl-1,4-benzoquinoneimine, 3-[4’-N-(ethylcarbamylmethyl)amino]phenylureido-6-methyl-1,4-benzoquinoneimine).;

[0069] The topical skin care composition may contain a natural pigment as a tanning agent. Non-limiting examples of natural pigments include caramel, beta-carotene, beet root extract, blue-green algae, cocoa powder, walnut extract, melanin, and curcumin.

[0070] (B) Aromatic sulfonate The topical skin care composition of the present invention may contain an aromatic sulfonate (B). Preferably, the aromatic sulfonate (B) has the formula (I)

[0071] [Chemical formula] or a solvate thereof, a tautomer thereof, a stereoisomer thereof, or a mixture thereof (wherein (i) R is an optionally substituted aryl or an optionally substituted heteroaryl, and (ii) X is a cation selected from the group consisting of a hydrogen ion, an ammonium ion, and an alkali metal ion).

[0072] The term "cation" includes, but is not limited to, a hydrogen ion, an ammonium ion (i.e., NH4 +This refers to positively charged ions including quaternary ammonium ions (e.g., tetraethylammonium, tetrabutylammonium), lithium ions, sodium ions, potassium ions, and silver ions. Preferably, aromatic sulfonate (B) is an alkali metal salt of aromatic sulfonate. In preferred embodiments, X is an alkali metal ion, such as lithium ions, sodium ions, and potassium ions. Most preferably, X is a sodium ion.

[0073] The aromatic sulfonate (B) may be an optionally substituted phenyl sulfonate, an optionally substituted naphthyl sulfonate, or both. In preferred embodiments, R is an optionally substituted aryl. In some embodiments, R is an optionally substituted phenyl. In some embodiments, R is an optionally substituted naphthyl. R may be an aryl or heteroaryl substituted with at least one substituent such as an optionally substituted alkyl, alkoxy, alkoxycarbonyl, carboxy, amino, hydroxy, thiol, halogen, cyano, and nitro. Alternatively, R may be an unsubstituted aryl or heteroaryl.

[0074] In some embodiments, R is an aryl or heteroaryl substituted with at least one linear, branched, or cyclic alkyl group having at least one carbon atom and up to 14, preferably up to 12, preferably up to 10, preferably up to 8, preferably up to 6 carbon atoms. In preferred embodiments, R is an aryl or heteroaryl substituted with at least one linear alkyl group, e.g., methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, n-decyl, and n-dodecyl. In preferred embodiments, R is substituted with at least one branched alkyl group, e.g., isopropyl, sec-butyl, isobutyl, isobutyl, tert-butyl, isopentyl, neopentyl, and isohexyl. Most preferably, R is substituted with methyl or isopropyl.

[0075] The disadvantages of using common reducing sugars (e.g., dihydroxyacetone, erythrolose) alone as tanning agents include insufficient coloring, undesirable orange undertones, rapid fading, and uneven coating. The combination of a reducing sugar (A) (e.g., dihydroxyacetone), an aromatic sulfonate (B), and a support (C) was unexpectedly discovered to produce a strong, long-lasting artificial tan with an aesthetically pleasing red / bronze hue, as discussed below. Without being bound by theory, it is believed that the aromatic sulfonate (B) herein facilitates a more advanced Maillard reaction by assisting the polymerization and / or conjugation of higher-degree-of-polymerization melanoidins, thereby resulting in a hue-modulated, strong coloring and fade-resistant tan.

[0076] Examples of exemplary aromatic sulfonates include, but are not limited to, phenyl sulfonates, such as sodium benzenesulfonate, sodium p-toluenesulfonate, sodium cumenesulfonate (i.e., sodium 4-isopropylbenzenesulfonate), sodium 2,3-dimethylbenzenesulfonate, sodium 2,5-dimethylbenzenesulfonate, 2,4,6-trimethylbenzenesulfonate, sodium 4-ethylbenzenesulfonate, sodium 4-propylbenzenesulfonate, sodium 4-tert-butylbenzenesulfonate, sodium 4-chlorobenzenesulfonate, sodium 4-bromobenzenesulfonate, sodium 4-hydroxybenzenesulfonate, sodium dodecylbenzenesulfonate, and sodium 3-sulfoammonium sulfate. Examples include sodium benzoate, potassium 4-sulfobenzoate, sodium 4-amino-3,5-dibromobenzenesulfonate, sodium 4-octylbenzenesulfonate, and sodium 4-dodecylbenzenesulfonate; naphthyl sulfonates, such as sodium 1-naphthalenesulfonate, sodium 2-naphthalenesulfonate, sodium 2-methyl-1-naphthalenesulfonate, sodium 4-methyl-1-naphthalenesulfonate, sodium 2-butyl-1-naphthalenesulfonate, sodium 4-hydroxy-1-naphthalenesulfonate, sodium 4-amino-1-naphthalenesulfonate, sodium 6-hydroxy-2-naphthalenesulfonate, and sodium 5-amino-1-naphthalenesulfonate, as well as mixtures thereof.

[0077] In some embodiments, polymers or oligomers containing the aromatic sulfonate of formula (I) as repeating units, such as poly(4-styrenesulfonate sodium), poly(4-styrenesulfonate)ammonium salt, poly(4-styrenesulfonate), poly(2-styrenesulfonate sodium), and polyanetholesulfonate sodium, may be used instead of or in addition to the aforementioned aromatic sulfonates.

[0078] In preferred embodiments, the aromatic sulfonate (B) is at least one selected from the group consisting of sodium 2-naphthalenesulfonate, sodium p-toluenesulfonate, sodium cumenesulfonate, sodium 4-dodecylbenzenesulfonate salt, and poly(sodium 4-styrenesulfonate), and more preferably at least one selected from the group consisting of sodium 2-naphthalenesulfonate (available from Sugai Chemical), sodium p-toluenesulfonate, and sodium cumenesulfonate.

[0079] As used herein, the topological polar surface area (tPSA) of a molecule is defined as the sum of the surface contributions of polar atoms in the molecule (e.g., oxygen and nitrogen atoms, and bonded hydrogen atoms). Methods for calculating tPSA are known to those skilled in the art (see, for example, Ertl, P. et al., "Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties," J.Med.Chem.2000, 43, 3714-3717, which is incorporated herein by reference in its entirety). For example, tPSA can be determined using a desktop computer and commercially available chemical graphics software such as ChemAxon-Marvinview and ChemDraw. Alternatively, tPSA can be found in many chemical databases such as SciFinder.

[0080] In the present invention, the aromatic sulfonate (B) useful is 100 Å. 2 Less than, for example, about 20 Å 2 Therefore, preferably about 30 Å 2 More preferably, about 40 Å 2 More preferably, about 50 Å 2 From, and up to approximately 95 Å 2 Preferably, a maximum of about 90 Å 2Preferably, a maximum of approximately 80 Å 2 Preferably, a maximum of about 70 Å 2 More preferably, up to approximately 65 Å 2 More preferably, up to approximately 60 Å 2 It has a topological polar surface area (tPSA).

[0081] As used herein, a hydrogen bond donor site is a functional group having a hydrogen atom that readily coordinates with an electronegative atom such as oxygen, nitrogen, and sulfur. Examples of hydrogen bond donor sites include NH functional groups in hydroxy, carboxylic acids, thiols, sulfonic acids, primary amines, secondary amines, and amides. In preferred embodiments, the aromatic sulfonate (B) has up to two hydrogen bond donor sites, preferably up to one, and more preferably zero.

[0082] While we do not wish to be bound by theory, aromatic sulfonates (B) exhibit better skin penetration and higher skin absorption the lower their tPSA value and / or the fewer hydrogen bond donors they have, which may be advantageous for self-tanning skincare compositions.

[0083] In some embodiments, the aromatic sulfonate (B) is present in an amount of at least about 0.05% by weight, preferably at least about 0.1% by weight, preferably at least about 0.5% by weight, preferably at least about 1% by weight, more preferably at least about 1.5% by weight, even more preferably at least about 2% by weight, even more preferably at least about 2.5% by weight, and up to about 10% by weight, preferably up to about 8% by weight, preferably up to about 6% by weight, preferably up to about 5% by weight, preferably up to about 4% by weight, more preferably up to about 3.5% by weight, even more preferably up to about 3% by weight, and even more preferably up to about 2.75% by weight, based on the total weight of the topical skincare composition.

[0084] (C) Carrier The topical skincare composition of the present invention may include a carrier (C), which is a material capable of enhancing the uniform delivery and penetration of the tanning agent (and other components of the topical skincare composition) into the skin, in order to achieve a deeper, richer, and longer-lasting tan.

[0085] Examples of suitable carriers (C) for use herein include, but are not limited to, benzyl alcohol, 2-phenylethyl alcohol, phenoxyethanol, methanol, ethanol, n-propanol, iso-propanol, n-butanol, sec-butanol, iso-butanol, tert-butanol, hexanol, n-octanol, 2-octanol, 2-ethylhexanol, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, and mixtures thereof.

[0086] In some embodiments, the carrier (C) comprises an aromatic alcohol. Due to the presence of polar (hydroxyl) and non-polar (phenyl) ends, aromatic alcohols (e.g., benzyl alcohol, 2-phenylethyl alcohol, phenoxyethanol) can enable more effective transdermal delivery of tanning agents (and other components of topical skincare compositions) than other short-chain alkyl alcohols such as ethanol and n-butanol. Furthermore, benzyl alcohol is particularly advantageous due to its moderate water solubility, aromatic fragrance, antimicrobial properties, and low toxicity. In preferred embodiments, the carrier (C) used in the present invention may include benzyl alcohol, 2-phenylethyl alcohol, 1-phenylethanol, phenoxyethanol, or mixtures thereof. Most preferably, the carrier (C) comprises or is essentially derived from benzyl alcohol (available from Emerald Kalama Chemical).

[0087] In some embodiments, the amount of carrier (C) present in the topical skin care composition is from about 0.1% by weight, preferably from about 0.5% by weight, preferably from about 1% by weight, preferably from about 1.5% by weight, preferably from about 2% by weight, and up to about 5% by weight, preferably up to about 4% by weight, preferably up to about 3% by weight, preferably up to about 2.5% by weight, relative to the total weight of the topical skin care composition.

[0088] The weight ratio between the reducing sugar (A) (e.g., dihydroxyacetone), the aromatic sulfonate (B) (e.g., sodium 2-naphthalenesulfonate, sodium p-toluenesulfonate), and the support (C) (e.g., benzyl alcohol) can vary depending on the desired tanning color (e.g., darkness, hue angle, hue saturation). However, typically, the weight ratio of aromatic sulfonate (B) to reducing sugar (A) ((B):(A)) is from 1:20, preferably from 1:15, preferably from 1:10, preferably from 1:8, preferably from 1:6, preferably from 1:5, preferably from 1:4, preferably from 1:3, more preferably from 1:2, even more preferably from 2:3, even more preferably from 1:1, and up to 20:1, preferably up to 15:1, preferably up to 10:1, preferably up to 8:1, preferably up to 6:1, preferably up to 5:1, preferably up to 4:1, preferably up to 3:1, more preferably up to 2:1, even more preferably up to 3:2, and even more preferably up to 5:4.

[0089] In some embodiments, the weight ratio of aromatic sulfonate (B) to support (C) ((B):(C)) is from 1:4, preferably 2:7, preferably 1:3, preferably 2:5, more preferably 1:2, even more preferably 2:3, even more preferably 1:1, and up to 4:1, preferably up to 7:2, preferably up to 3:1, preferably up to 5:2, more preferably up to 2:1, even more preferably up to 3:2, and even more preferably up to 5:4.

[0090] (D) Organic solvents The topical skincare composition may optionally contain an organic solvent (D) that is structurally different from the carrier (C). The organic solvent (D) can help solubilize components that are not sufficiently soluble in the carrier, and can modify the surface properties of the topical skincare composition to enhance processability, viscosity and / or ease of handling, or generally to provide a medium suitable for self-tanning operations. Examples of organic solvents useful in the present invention, but not limited to these, include polyols, e.g., ethylene glycol, propylene glycol (e.g., 1,3-propanediol, 1,2-propanediol), butylene glycol (e.g., 1,3-butanediol, 1,2-butanediol, 1,4-butanediol, 2,3-butanediol), hexylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, glycerin, polyol ethers (e.g., ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol monomethyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether), and C1-C4 lower alkanols, e.g., methanol, ethanol, isopropanol, butanol, and mixtures thereof. In some embodiments, the organic solvent (D) includes a polyol which is at least one selected from the group consisting of 1,3-propanediol, 1,2-propanediol, ethylene glycol, glycerin, and 1,3-butanediol (available from OXEA). In a preferred embodiment, the organic solvent (D) is 1,3-propanediol.

[0091] Alternatively, a mixture of polyols, for example, a mixture of a first polyol and a second polyol different from the first polyol, may be used as the organic solvent (D). In some embodiments, the first polyol is 1,3-propanediol. In some embodiments, the second polyol is glycerin. When a mixture of the first polyol (e.g., 1,3-propanediol) and the second polyol (e.g., glycerin) is used, the weight ratio of the first polyol to the second polyol can typically be from 1:6, preferably 1:5, preferably 1:4, preferably 1:3, more preferably 1:2, more preferably 1:1, even more preferably 3:2, even more preferably 2:1, and up to 10:1, preferably up to 8:1, preferably up to 6:1, more preferably up to 5:1, even more preferably up to 4:1, and even more preferably up to 3:1.

[0092] If present, the organic solvent (D) may be included in the topical skincare composition in an amount ranging from about 0.2% by weight, preferably about 0.5% by weight, more preferably about 1% by weight, preferably about 2% by weight, more preferably about 3% by weight, even more preferably about 4% by weight, even more preferably about 5% by weight, and up to about 20% by weight, preferably up to about 15% by weight, preferably up to about 12% by weight, more preferably up to about 10% by weight, even more preferably up to about 8% by weight, and even more preferably up to about 6% by weight, relative to the total weight of the topical skincare composition.

[0093] The weight ratio of carrier (C) (e.g., benzyl alcohol) to organic solvent (D) (e.g., 1,3-propanediol, ethylene glycol, glycerin) can range from 1:200, preferably 1:150, preferably 1:100, preferably 1:50, preferably 1:25, preferably 1:20, preferably 1:10, more preferably 1:8, even more preferably 1:6, even more preferably 1:5, and up to 25:1, preferably up to 20:1, preferably up to 15:1, preferably up to 10:1, preferably up to 5:1, preferably up to 3:1, preferably up to 2:1, preferably up to 1:1, more preferably up to 1:2, even more preferably up to 1:3, and even more preferably up to 1:4.

[0094] (E)Water In some embodiments, the topical skincare composition of the present invention is an aqueous composition or an oil-in-water (o / w) emulsion in which the continuous phase is aqueous. Therefore, in preferred embodiments, the topical skincare composition further contains water (E) in an amount of at least about 10% by weight, preferably at least about 20% by weight, preferably at least about 30% by weight, preferably at least about 40% by weight, more preferably at least about 50% by weight, even more preferably at least about 60% by weight, still more preferably at least about 70% by weight, and up to about 95% by weight, preferably up to about 90% by weight, more preferably up to about 85% by weight, and even more preferably up to about 80% by weight, based on the total weight of the topical skincare composition.

[0095] (F) Thickening agent The topical skincare composition may optionally contain a thickener (F) that improves the stability of the composition and also provides a skin-friendly viscosity upon application.

[0096] The thickening agent (F) may include a copolymer containing at least one selected from the group consisting of hydroxyalkyl acrylates, acrylates, acrylamides, and acryloyldialkyl taurates as a structural unit. Examples of thickening copolymers include copolymers of hydroxyethyl acrylate and sodium acryloyldimethyltaurate, copolymers of acrylate and sodium acryloyldimethyltaurate, copolymers of acrylamide and acrylate, and copolymers of acrylic acid, acrylamide, acrylate and sodium acryloyldimethyltaurate. Preferably, the thickening agent (F) contains an anionic (co)polymer.

[0097] These thickening copolymers are commercially available, for example, from SEPPIC, France. Examples of thickeners containing copolymers of hydroxyethyl acrylate and acryloyldimethyl taurate include SEPINOV® EMT 10 (hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer), SIMULGEL® NS (hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, squalane, polysorbate 60), SIMULGEL® FL (hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate 60), SEPIPLUS® S (hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, polyisobutene, PEG-7 trimethylolpropane coconut ether), and SIMULGEL® INS 100 (hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, isohexadecane polysorbate 60). Examples of thickeners containing copolymers of acrylate and acryloyldimethyltaurate include SIMULGEL® EG (sodium acrylate / sodium acryloyldimethyltaurate copolymer, isohexadecane, polysorbate 80), SIMULGEL® EPG (sodium acrylate / sodium acryloyldimethyltaurate copolymer, polyisobutene, caprylylcaprylglucoside), and SIMULGEL® SMS 88 (sodium acrylate / acryloyldimethyltaurate / dimethylacrylamide crosspolymer, isohexadecane, polysorbate 60). An example of a thickener containing copolymers of acrylamide and acrylate is SEPIPLUS® 265 (acrylamide / ammonium acrylate copolymer, polyisobutene, polysorbate 20). An example of a thickening agent containing copolymers of acrylic acid, acrylamide, acrylate, and acryloyldimethyltaurate is SEPIPLUS® 400 (polyacrylate-13, polyisobutene, polysorbate 20).

[0098] In some embodiments, the thickener (F) contains a copolymer of hydroxyethyl acrylate and sodium acryloyldimethyl taurate. More preferably, the thickener is SEPIPLUS™ S (hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, polyisobutene, PEG-7 trimethylolpropane coconut ether).

[0099] Other thickening materials that can be used in addition to or instead of the aforementioned thickening agents include carbomer (e.g., carbomer 980), C 10~30 Alkyl acrylate crosspolymer (e.g., Pemulen TR-1, Pemulen TR-2 (acrylate / C) 10~30 Alkyl acrylate crosspolymer, SEPIGEL (trademark) 305 (polyacrylamide, C 13~14 Examples include isoparaffin (laureth-7), SIMULGEL® A (ammonium polyacrylate, isohexadecane, PEG-40 castor oil), SIMULGEL® 600 (acrylamide / sodium acryloyldimethyltaurate copolymer, isohexadecane, polysorbate 80), ARISTOFELX® AVC (ammonium acryloyldimethyltaurate / N-vinylpyrrolidone copolymer), ARISTOFELX® AVS (sodium acryloyldimethyltaurate / N-vinylpyrrolidone copolymer), and modified cellulose polymers (e.g., hydroxyethylcellulose, methylcellulose).

[0100] As used herein, cationic copolymer refers to a copolymer comprising a cationic monomer, which is a methacryloylethyltri(C1-C3 alkyl)ammonium salt or an acryloylethyltri(C1-C3 alkyl)ammonium salt (e.g., acryloylethyltrimethylammonium chloride), as one of its repeating units, unless otherwise specified. Examples of monomers that may be used to form cationic copolymers with methacryloylethyltri(C1-C3 alkyl)ammonium salts or acryloylethyltri(C1-C3 alkyl)ammonium salts include acrylamide, methacrylamide, tris(hydroxymethyl)acrylamidomethane, and those disclosed in U.S. Patent No. 7,780,954, which are incorporated herein by reference in whole.

[0101] In preferred embodiments, the topical skincare composition is substantially free of cationic copolymers, which includes being substantially free, preferably completely free (i.e., 0% by weight) of the aforementioned cationic copolymers, such as acrylamide / acryloylethyltrimethylammonium chloride / tris(hydroxymethyl)-acrylamidomethane copolymer.

[0102] (G) Preservatives The topical skincare composition may optionally further contain a preservative (G). For example, the preservative may be selected to kill bacteria that might otherwise be maintained or proliferate in the composition, or to prevent deterioration or chemical decomposition (e.g., oxidative decomposition) of the composition. Preservatives suitable for use in cosmetic compositions are well known to those skilled in the art. In this regard, the preservative selected may vary depending on the specific components present in the topical skincare composition. Examples of suitable preservatives include methylparaben, ethylparaben, propylparaben, EDTA or its salts (e.g., disodium EDTA), phenoxyethanol, DMDM ​​hydantoin, benzyl alcohol, ethyl dibromoglutaronitrile-phenoxyethanol / polyquatemium-7 (Euxyl K-400, Calgon), imidazolidinyl urea, diazolidinyl urea, benzalkonium chloride, benzethonium chloride, sodium benzoate, sorbic acid, or combinations thereof.

[0103] Preferably, preservative (G) is methylparaben and / or ethylparaben, most preferably a mixture of these preservatives. If present, preservative (G) may be present in the present invention in an amount of up to about 5% by weight, preferably up to about 4% by weight, preferably up to about 3% by weight, preferably up to about 2% by weight, preferably up to about 1% by weight, preferably up to about 0.5% by weight, based on the total weight of the topical skin care composition, for example, about 0.001% to about 3% by weight, or 0.1% to about 1.5% by weight, or 0.15% to about 1% by weight, or 0.3% to about 0.45% by weight.

[0104] (H) Acidulant The topical skincare composition of the present invention may optionally be formulated to include an acidulant (H) to adjust the pH to be more acidic / weakly alkaline. Furthermore, depending on the chemical structure, the acidulant (H) may act as a chelating and / or buffering agent to neutralize minerals, enhance the activity of any preservatives present, and stabilize active ingredients (e.g., tanning agents).

[0105] The acidulants used in the present invention may be inorganic or organic acids, and are not limited to these, but include hydrochloric acid, orthophosphoric acid, sulfuric acid, carboxylic acids such as fumaric acid, acetic acid, and α-hydroxy acids such as tartaric acid, citric acid, malic acid, lactic acid, and glycolic acid, as well as mixtures thereof. If the acidulant contains an α-hydroxy acid functional group, the acidulant may also help exfoliate the skin and soften wrinkles. Citric acid is preferably used.

[0106] If present, the acidulant (H) may be present in the present invention in an amount of up to about 5% by weight, preferably up to about 4% by weight, preferably up to about 3% by weight, preferably up to about 2% by weight, preferably up to about 1% by weight, based on the total weight of the topical skin care composition, for example, about 0.001% to about 3% by weight, or 0.02% to about 2% by weight, or 0.1% to about 1% by weight, or 0.2% to about 0.5% by weight. The pH of the topical skin care composition may vary, but is preferably less than 6.5, for example, at least 2, preferably at least 2.5, more preferably at least 3, even more preferably at least 3.5, and at most 6, preferably at most 5, more preferably at most 4.

[0107] Other optional components Various optional components frequently used in topical compositions, such as fragrances, pressurized gases, vehicles, adjuvants, anti-aging components, proteins, rheology control agents, dispersants, thickeners, film-forming agents, chelating agents, cleansing agents, vitamins, plant-derived substances, and sunscreens, as well as other classes of materials whose presence may be desirable for cosmetic, medical, or other reasons, may optionally be included at usage levels established in the prior art. For example, the topical skincare composition of the present invention may optionally be prepared to include one or more fragrances known to those skilled in the field of cosmetics in order to impart a pleasant scent or to help mask any malodorous components that may be present in the topical skincare composition.

[0108] In preferred embodiments, the topical skincare composition is substantially free of such optional components, but if included, non-limiting examples of which may be used include film-forming materials, such as petrolatum, hydrolyzed wheat protein / wheat oligosaccharides (e.g., Croda Inc.).Cropeptide W), hydrolyzed corn protein, hydrolyzed wheat gluten, hydrolyzed yeast protein, hydrolyzed plant protein, hydrolyzed soy protein, hydrolyzed rice protein and hydrolyzed potato protein; humectants, e.g., glycereth-7-triacetate (Dermol GL-7-A, Alzo), glycereth-5-lactate and glycereth-7-diisononanoate; skin conditioning agents and emollients, e.g., mineral oil, cetearyl alcohol, silicones, e.g., dimethicone, cyclomethicone, phenyl trimethicone, alkyl dimethicone, fluorine-modified silicones, esters of isononanoates, e.g., ethylhexyl isononanoate, butylene glycol diisononanoate, cetearyl isononanoate and cetyl isononanoate, and polyethyl glycol derivatives of castor oil, e.g., PEG-40 castor oil (Surfactol 365 (available from Vertellus), PEG-45 castor oil, PEG-50 castor oil, PEG-60 castor oil and PEG-100 castor oil; surfactants, e.g., polyoxyalkylene ethers of fatty alcohols, e.g., laureth-3, ceteareth-6, ceteareth-11, ceteareth-15, ceteareth-16, ceteareth-17, ceteareth-18, ceteareth-20, ceteareth-23, ceteareth-25, ceteareth-27, ceteareth-28, ceteareth-30, isoceteth-20, laureth-9 / mileth-9 and PPG-3 caprylyl ether, steareth (steareth-2, steareth-4 Examples include steareth-6, steareth-7, steareth-10, steareth-11, steareth-13, steareth-15, steareth-20), and polyethylene glycol esters, such as PEG-14 laurate, PEG-15 laurate, PEG-20 laurate, PEG-32 laurate, PEG-75 laurate, PEG-150 laurate, or other surfactants; as well as sunscreens or UV light absorbing compounds, such as octyldimethyl PABA, benzophenone-4, DEA methoxycinnamate, 2-phenyl-benzimidazole-5-sulfonic acid, and triethanolamine salicylate.

[0109] In preferred embodiments, the topical skincare composition comprises 1-3% by weight of reducing sugars (A) (e.g., dihydroxyacetone, erythritol), 1-3% by weight of aromatic sulfonates (B) (e.g., sodium 2-naphthalenesulfonate, sodium p-toluenesulfonate, or both) based on the total weight of the topical skincare composition, 1-3% by weight of a carrier (C) (e.g., benzyl alcohol), 2-8% by weight of organic solvents (D) (e.g., 1,3-propanediol, 1,2-propanediol, ethylene glycol, glycerin, 1,3-butanediol), and 70-82% by weight of water (E), the remainder optionally comprising a preservative (G) (e.g., a mixture of methylparaben and ethylparaben), an acidulant (H) (e.g., citric acid), and a thickener (F) (e.g., SEPIPLUS Contains one or more of S(hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, polyisobutene, PEG-7 trimethylolpropane coconut ether).

[0110] In a preferred embodiment, the topical skincare composition comprises 1-3% by weight of a reducing sugar (A) (e.g., dihydroxyacetone), 1-3% by weight of an aromatic sulfonate (B) (e.g., sodium 2-naphthalenesulfonate, sodium p-toluenesulfonate, or both), 1-3% by weight of a carrier (C) (e.g., benzyl alcohol), and 2-8% by weight of an organic solvent (D) (e.g., 1,3-propanediol, 1,2-propanediol, ethylene glycol) based on the total weight of the topical skincare composition. It contains glycerin, 1,3-butanediol, 70-82% by weight of water (E), 0.001-1% by weight of a preservative (G) (e.g., a mixture of methylparaben and ethylparaben), 0.001-0.2% by weight of an acidulant (H) (e.g., citric acid), and 1-3% by weight of a thickener (F) (e.g., SEPIPLUS® S (hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, polyisobutene, PEG-7 trimethylolpropane coconut ether)).

[0111] The topical skincare composition of the present invention can be prepared by any method known to those skilled in the art. For example, a water-containing topical skincare composition can be prepared by (i) mixing all water-soluble components except tanning agents (e.g., reducing sugars) together with water in a vessel of appropriate size, while optionally heating (e.g., 40-90°C, preferably 50-85°C, more preferably 75-81°C), and mixing until homogeneous; (ii) mixing all oil phase components, if present, in another vessel, while optionally heating (e.g., 40-90°C, preferably 50-85°C, more preferably 75-81°C), and stirring until homogeneous; and (iii) optionally heating (e.g., 40-90°C The product can be prepared by (i) mixing the homogeneous mixture from (i) together with the homogeneous mixture from (ii), if present, while cooling to a temperature of °C, preferably 50 to 85 °C, more preferably 75 to 81 °C, until a homogeneous aqueous composition or a uniform oil-in-water emulsion is formed; (iv) cooling the homogeneous aqueous composition or the uniform oil-in-water emulsion; and (v) after cooling, optionally adding a tanning agent (e.g., reducing sugar) to the homogeneous aqueous composition or the uniform oil-in-water emulsion while mixing under the same conditions as above, thereby forming a topical skin care composition. If present, a thickening agent may be added during step (i) or after step (iii) and before the addition of the tanning agent (i.e., before step (v)). After cooling, the resulting topical skin care composition may then be filled into desired packaging. Mixing may be carried out by propulsion devices, such as high-shear mixers and high-speed dissolvers.

[0112] How to self-tan In one or more embodiments, the present invention provides a method for adjusting skin color by applying a topical skincare composition topically to a target area of ​​skin.

[0113] To achieve an acceptable degree of coloring or tanning, those who desire such coloring or tanning can apply an effective amount of topical skincare composition evenly over the desired area of ​​body surface for an effective application time. Thus, topical skincare compositions can be applied to produce a slight change in skin color or a more dramatic tanning effect. Furthermore, the method of the present invention can produce a rich, deep, aesthetically satisfying, and long-lasting tan on the skin by altering the hue angle and simultaneously increasing the saturation and darkness of the skin color.

[0114] Topical skincare compositions can be applied topically to moist or dry skin. Preferably, the desired skin area is cleansed and / or exfoliated before application. During application, the topical skincare composition may be spread directly onto the skin, for example, by hand or using an applicator such as a wipe, puff, roller, or spray. The topical skincare composition may be used as a single treatment to color the skin, or it may be applied in layers, with subsequent applications increasing the intensity of the tan, until the desired degree of coloring is achieved.

[0115] The topical skincare composition may be applied to the desired area, preferably 1 to 4 times a day, preferably 2 to 3 times a day, as needed. Application may be carried out for at least 1 day, preferably at least 2 consecutive days, more preferably at least 3 consecutive days, even more preferably at least 4 consecutive days, and up to 14 consecutive days, preferably up to 7 consecutive days, more preferably up to 6 consecutive days, and even more preferably up to 5 consecutive days. Alternatively, application may be carried out intermittently. Applications outside these ranges may also be used, as needed, to change the degree of coloration.

[0116] The way we perceive colors (for example, skin color) can be described in terms of hue (color), lightness (brightness), and saturation (vividness). Hue is the primary attribute of color vision used to represent "unique hues" (e.g., red, yellow, blue) that are considered to be completely different hues. Saturation (also called chroma or colorfulness) indicates the "purity" of a particular hue. Highly saturated hues have vivid and strong colors, while less saturated hues appear duller and less vibrant. If there is no saturation at all, the hue becomes a grayish color. Lightness represents the brightness or darkness of a color. For example, an image with a higher lightness value reflects more light.

[0117] The quantification of these color attributes (hue, saturation, and lightness) is carried out by the CIE (International Commission on Illumination). * a * b * (CIELAB) Color Space Model, CIE L * C * This can be done using various color models, including the h° (CIEHCL) color space model, the CIE XYZ model, and the RGB color model.

[0118] In some embodiments, skin color as used herein is CIE L * a * b * Measured using the model, where (i)L * (ii)a * (iii)b * This indicates the yellow / blue value of the color. In some embodiments, skin color as used herein is CIE L * C * Measured using the h° model, where (i)L * This indicates the brightness of the color, CIE L * a * b * Model L * (ii)C *(iii) h° indicates chroma, where the value starts from 0, indicating no chroma, and reaches 60, indicating full saturation, and h° indicates the hue angle. As shown in the chromaticity diagram (Figure 9), the hue angle of skin tones in this specification is expressed in degrees, +a * It starts on the axis. Specifically, a hue angle of 0° is red (+a * ) and a hue angle of 90° is yellow (+b * ) The skin color attributes described herein can be measured by a spectrophotometer such as the CM-700d, CM-2500d, or CM-2600d spectrophotometer manufactured by Konica Minolta.

[0119] The method of the present invention can shift the hue of the skin after application of a topical skincare composition. In some embodiments, the method of the present invention reduces or increases the hue angle h° of the skin color by at least about 0.1°, preferably at least about 0.2°, preferably at least about 0.3°, preferably at least about 0.4°, more preferably at least about 0.5°, even more preferably at least about 0.6°, even more preferably at least about 0.7°, and up to about 2°, preferably up to about 1.5°, preferably up to about 1.2°, more preferably up to about 1°, and even more preferably up to about 0.8°, compared to the hue angle before topical application.

[0120] Preferably, the method of the present invention reduces the h° h of the skin color by, for example, at least about 0.2°, preferably at least about 0.3°, preferably at least about 0.4°, more preferably at least about 0.5°, even more preferably at least about 0.6°, still more preferably at least about 0.7°, and up to about 1.5°, preferably up to about 1.2°, more preferably up to about 1°, and even more preferably up to about 0.8°, compared to the h° h of the skin color before topical application (see Figure 5). A reduction in the h° h of the treated skin typically indicates that the topical skincare composition produces a bronze or reddish tint when applied to the skin.

[0121] The method of the present invention can darken the skin color after application of a topical skincare composition. In some embodiments, the method of the present invention can darken the lightness L of the skin color. * The lightness is reduced by at least about 1%, preferably at least about 2%, preferably at least about 3%, preferably at least about 4%, more preferably at least about 5%, even more preferably at least about 6%, even more preferably at least about 7%, and up to about 20%, preferably up to about 15%, preferably up to about 12%, more preferably up to about 10%, and even more preferably up to about 8%, compared to the lightness before local application.

[0122] In a preferred embodiment, the method of the present invention simultaneously changes the hue angle and reduces the brightness of the treated skin according to the range specified above.

[0123] It is worth noting that combinations of reducing sugars (A) (e.g., dihydroxyacetone, erythritolose), aromatic sulfonates (B) (e.g., sodium 2-naphthalenesulfonate, sodium p-toluenesulfonate), and a carrier (C) (e.g., benzyl alcohol) yield unexpected tanning results (darker, longer-lasting (i.e., more fade-resistant), and more aesthetically pleasing coloring) compared to using reducing sugars alone.

[0124] For example, as shown in Figure 5, using reducing sugars alone does not significantly reduce the hue angle of the treated skin, and in some cases, the hue angle actually increases after prolonged application (e.g., after 7 days of application). However, combining aromatic sulfonates (B) and carriers (C) with reducing sugars (A) significantly reduces the hue angle and thus imparts an aesthetically pleasing red / bronze tint to the treated skin. As shown in Figure 4, using reducing sugars alone results in at least 30% less, preferably at least 35% less, more preferably at least 40% less, even more preferably 45% less, and up to 70% less, preferably up to 60% less, and more preferably up to 50% less reduction in skin brightness compared to using the combination of reducing sugars (A), aromatic sulfonates (B), and carriers (C). Furthermore, the artificial tanning produced by this combination fades significantly slower than using reducing sugars alone (e.g., fading after 3 days is less than approximately 40% vs. at least 80%).

[0125] The method of the present invention may be used to adjust the saturation of skin color. In some embodiments, the method of the present invention adjusts the saturation of the treated skin color C * The saturation is increased by at least about 1%, preferably at least about 2%, preferably at least about 3%, preferably at least about 4%, more preferably at least about 5%, even more preferably at least about 6%, even more preferably at least about 7%, and up to about 20%, preferably up to about 15%, preferably up to about 12%, more preferably up to about 10%, and even more preferably up to about 8%, compared to the saturation before local application.

[0126] The following examples are intended to further illustrate topical skincare compositions and are not intended to limit the scope of the claims. [Examples]

[0127] Topical skincare composition Examples 1-3 below show some examples of topical skincare compositions, including the comparative composition used to evaluate tanning performance. The amount of each component is expressed as a weight percentage relative to 100% of the total weight. DHA represents dihydroxyacetone, available from EMD Millipore. NSA represents sodium 2-naphthalenesulfonate, available from Sugai Chemical. pTS represents sodium p-toluenesulfonate. BA represents benzyl alcohol, available from Kalama. 1,3-butylene glycol, methylparaben, ethylparaben, and SEPIPLUS® S are available from Oxea, Ueno, Sharon, and Seppic, respectively. PD represents propanediol. GLY represents glycerin. * This indicates that the example is a comparative example.

[0128] Example 1 [Table 1]

[0129] Example 2 [Table 2]

[0130] Example 1 * And 2 are the compositions “prototype” and “control” tested in Figures 1A to 1D, respectively; Example 3 * 4 and 5 are the compositions “Control”, “NSA”, and “pTS”, respectively, tested in Figures 2 and 3; Example 6 * And 7 are the compositions “Control DHA” and “+NSA / BA” tested in Figures 4 and 5, respectively.

[0131] As shown in Table 1 and the related drawings, topical skincare compositions containing reducing sugars (e.g., DHA, erythrolose) in combination with aromatic sulfonates (e.g., NSA, pTS) (Examples 2, 4, 5, and 7) are used when reducing sugars are used alone (Comparative Example 1). * , 3 *and 6 * Compared to other methods, it achieved remarkable tanning results in terms of darkness (more effective darkening), hue (more aesthetically pleasing red / bronze shades), and fade resistance (longer-lasting color).

[0132] Example 3 [Table 3]

[0133] Example 1 * Examples 2 and 3 are compositions “Control,” “pTS,” and “NSA,” respectively, tested in Figures 7A, 7B, and 7C; Examples 4, 5, 6, and 7 are compositions containing DHA, NSA, BA, and 1,3-propanediol (PD) in a weight ratio of 2:2:10 (Example 4), DHA, NSA, PD, and glycerin (Gly) in a weight ratio of 2:2:7.5:2.5 (Example 5), DHA, NSA, PD, and Gly in a weight ratio of 2:2:5:5 (Example 6), and DHA, NSA, PD, and Gly in a weight ratio of 2:2:2.5:7.5 (Example 7); Example 8 * 9, 10, 11, and 12 are the compositions "DHA", "DHA / NSA", "DHA / p-toluenesulfonate sodium", "DHA / cumenesulfonate sodium", and "DHA / polystyrenesulfonate sodium", respectively, which were tested in Figures 8A to E.

[0134] Manufacturing method The following is an exemplary method for producing an example of a topical skincare composition. Part A: First, deionized water and 1,3-butylene glycol were added to the main vessel and thoroughly mixed. The main vessel was heated to a temperature of 75-81°C. When the vessel temperature reached 75°C, parabens, BA, and NSA were added to the main vessel and mixed until clear. Then, heating was stopped. SEPIPLUS® S was added to the main vessel and mixed for about 20 minutes. After the addition of SEPIPLUS® S, gradual mixing was applied as needed to increase the viscosity of the mixture. The main vessel was cooled to a temperature below 40°C, thereby forming Part A.

[0135] Part B: Deionized water and DHA were added to a separate vessel and mixed until clear to form Part B.

[0136] After cooling Part A to a temperature below 40°C, Part B was added to Part A to form Part AB, which was then mixed for approximately 5 minutes.

[0137] Finally, citric acid was added to parts A and B to adjust the pH to 3.5-4.0, thereby obtaining a topical skincare composition.

[0138] Evaluation method for topical skin care compositions (1) Skin test An example of the composition is 2 mg / cm³. 2 The amount was applied to the skin. Skin color parameters (e.g., lightness L) * The hue angle (h°) was measured before application and at various points in time after application of the test composition specified in each test, and the change (ΔL) of each parameter was then compared to the parameter before application. * The Δh° was calculated. Specifically, a CM-2600d manufactured by Konica Minolta, Inc. was used as the colorimeter.

[0139] Skin studies could be conducted as consumer home use studies. For example, the data in Figures 4 and 5 were collected by the following method: Consumers applied one lotion product containing either DHA alone ("control DHA") or DHA, NSA, and BA ("+NSA / BA") once daily to their arms and legs for 7 days. Color measurements were taken on the arms and legs at baseline (day 0), day 3, and day 7. On day 7 from the start, panelists stopped using the test composition. Further color measurements were taken on the arms and legs on day 10.

[0140] (2) Protein solid gel model test Preparation of protein solid gel samples: Equipment: Digital scale (0.01g accuracy), 600mL beaker, three 300mL beakers, large water bath, two stainless steel insulators to fit the 300mL beakers, two micro spatulas or tongue depressors, 36 Falcon petri dishes with lids, and volumetric pipettes.

[0141] Ingredients: Deionized water (DI water), gelatin A (Gel A) stored at room temperature on a bench, and bovine serum albumin (BSA) (stored at 5°C in the laboratory refrigerator).

[0142] Preparation of Gelatin A Premix: (i) The tare weight of a 600 mL beaker + micro spatula / tongue depressor was obtained; (ii) 40 g of Gel A was added to the beaker; (iii) Add DI water to the beaker to make a total of 200 g of solution; (iv) The beaker containing the solution was placed in the water bath; (v) The water bath temperature was set to 60°C; (vi) Use a micro spatula / tongue depressor to frequently and slowly mix the solution in the beaker to prevent film formation on the surface of the solution; (vii) The solution was mixed until homogeneous. This sometimes took up to an hour.

[0143] Preparation of BSA premix: (i) The tare weight of a 300 mL beaker + micro spatula / tongue depressor was obtained; (ii) 8 g of BSA was added to the beaker; (iii) Add DI water to the beaker to make a total of 200 g of solution; (iv) The solution was slowly mixed using a micro spatula / tongue depressor; (v) Mix the solution until homogeneous. This sometimes took up to an hour (no heat was applied as BSA can decompose at high temperatures); and (vi) Place the remaining two empty 300 mL beakers in stainless steel insulators and place them in a water bath. A weight bar may be used to keep the beakers submerged if necessary.

[0144] Preparation of Petri dishes: (i) The weight of each plate, excluding the lid, was measured and the value was recorded on the side of the plate; (ii) The plates were arranged in ascending order of weight; (iii) Each plate was marked on its side with a letter common to the set and an incrementing integer, for example, Y01, Y02, Y03...Y10, Y11, etc.

[0145] Premix combinations: (i) Once both the Gel A and BSA premix solutions had become clear and aeration was complete (each was pre-mixed with DI water to obtain a total of 200 g of solution; see above), the Gel A and BSA premix were each stirred for 2-3 minutes; (ii) The BSA premix was added to the Gel A premix by slowly pouring it into the beaker containing the Gel A premix from the inner circumference, thereby forming a combined protein solution; (iii) The combined protein solutions were slowly mixed for 2 minutes; (iv) Remove the insulators from the water bath and dry the outside of the two 300 mL beakers (as described in Section E, step (vi)) with a towel; and (v) The combined protein solutions were added to two insulated 300 mL beakers by slowly pouring equal volumes of the solution into each beaker from the inner circumference.

[0146] Preparation of gel plates: The desired amount of combined protein solution was added to a Petri dish using a volumetric pipette. The dish containing the solution was then dried on a bench to form a gel plate.

[0147] Measurement of the color of protein solid gels: Color measurements were performed using image analysis provided by ImageJ software.

[0148] The present invention also intends to include other embodiments "including," "consisting of," and "essentially consisting of" the embodiments or elements presented herein, whether expressly indicated or not.

[0149] Clearly, numerous modifications and variations of the present invention are possible in light of the above teachings. Therefore, it is understood that, within the scope of the appended claims, the present invention may be carried out in ways other than those specifically described herein.

[0150] All patents and other references mentioned above are incorporated fully herein by this reference, as they are shown in detail.

Claims

1. (A) 0.1 to 30% by weight of reducing sugars relative to the total weight of the topical skin care composition (B) Alkali metal salts of aromatic sulfonic acids, and (C) Carrier A topical skincare composition comprising, The reducing sugar (A) is dihydroxyacetone, erythrolose, or both. Alkali metal aromatic sulfonate (B) at 100 Å 2 At least one selected from the group consisting of sodium 2-naphthalenesulfonate, sodium p-toluenesulfonate, sodium cumenesulfonate, sodium 4-dodecylbenzenesulfonate salt, and poly(sodium 4-styrenesulfonate), having a topological polar surface area (tPSA) of less than , The carrier (C) contains an aromatic alcohol. Topical skincare composition.

2. The topical skincare composition according to claim 1, wherein the weight ratio ((B):(A)) of alkali metal salt of aromatic sulfonate (B) to reducing sugar (A) is 1:20 to 20:

1.

3. The topical skincare composition according to claim 1 or 2, wherein the carrier (C) contains benzyl alcohol.

4. (D) A topical skincare composition according to any one of claims 1 to 3, further comprising an organic solvent.

5. The topical skincare composition according to claim 4, wherein the organic solvent (D) comprises a polyol.

6. The topical skincare composition according to claim 4 or 5, wherein the weight ratio of the carrier (C) to the organic solvent (D) ((C):(D)) is 1:20 to 1:

2.

7. A topical skincare composition according to any one of claims 1 to 6, wherein the weight ratio ((B):(C)) of an alkali metal aromatic sulfonate salt (B) to a support (C) is 1:4 to 4:

1.

8. A topical skincare composition according to any one of claims 1 to 7, which is substantially free of cationic copolymers.

9. A method for adjusting the skin color of a subject, A step of applying the topical skincare composition according to any one of claims 1 to 8 topically to the target skin. Includes, Local application results in a decrease or increase of at least 0.5° in the h° h of the color compared to the h° method.

10. A method for adjusting the skin color of a subject, A step of applying the topical skincare composition according to any one of claims 1 to 8 topically to the target skin. Includes, Upon local application, the lightness L* of the color decreases by at least 10% and the hue angle of the color decreases or increases by at least 0.5°, compared to the lightness and hue angle before local application. method.

11. A method for adjusting the color saturation of the target skin, A step of applying the topical skincare composition according to any one of claims 1 to 8 topically to the target skin. Includes, Local application increases the color saturation C* by at least 10% compared to the saturation before local application. method.

12. A collection of topical skincare products for retail sale, (a) (A) 0.1 to 30% by weight of reducing sugars relative to the total weight of the topical skin care composition, (B) Alkali metal salts of aromatic sulfonic acids, and (C) Carrier Includes, The reducing sugar (A) is dihydroxyacetone, erythrolose, or both. Alkali metal aromatic sulfonate (B) at 100 Å 2 At least one selected from the group consisting of sodium 2-naphthalenesulfonate, sodium p-toluenesulfonate, sodium cumenesulfonate, sodium 4-dodecylbenzenesulfonate salt, and poly(sodium 4-styrenesulfonate), having a topological polar surface area (tPSA) of less than , The carrier (C) contains an aromatic alcohol, The weight ratio of alkali metal aromatic sulfonate salt (B) to reducing sugar (A) ((B):(A)) is 1:20 to 20:

1. A first topical skincare composition, (b) 0.1 to 30% by weight of reducing sugars relative to the total weight of the topical skin care composition (A), (B) Alkali metal salts of aromatic sulfonic acids, and (C) Carrier Includes, The reducing sugar (A) is dihydroxyacetone, erythrolose, or both. Alkali metal aromatic sulfonate (B) at 100 Å 2 At least one selected from the group consisting of sodium 2-naphthalenesulfonate, sodium p-toluenesulfonate, sodium cumenesulfonate, sodium 4-dodecylbenzenesulfonate salt, and poly(sodium 4-styrenesulfonate), having a topological polar surface area (tPSA) of less than , The carrier (C) contains an aromatic alcohol, The weight ratio of alkali metal aromatic sulfonate salt (B) to reducing sugar (A) ((B):(A)) is 1:20 to 20:

1. A second topical skincare composition, Includes, The amount of reducing sugar (A) present in the first topical skincare composition (a) is less than the amount of reducing sugar (A) present in the second skincare composition (b), and the amounts are, in each case, relative to the total weight of the first and second topical skincare compositions. collection.

13. The collection according to claim 12, wherein a first topical skincare composition (a) and a second topical skincare composition (b) are packaged separately.

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