Use of saponin compounds in nucleic acid sequencing

JP7863615B2Active Publication Date: 2026-05-21MGI TECH CO LTD
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
MGI TECH CO LTD
Filing Date
2021-10-15
Publication Date
2026-05-21

AI Technical Summary

Technical Problem

Conventional nucleic acid sequencing methods using photoprotective agents suffer from high concentration issues that lead to salt precipitation, oxidation, and increased costs, affecting sequencing quality and efficiency.

Method used

The use of saponin compounds, such as notoginsenosides and ginsenosides, as photodamage protectants at very low concentrations in scanning reagents, which do not absorb UV-visible light and maintain sequencing quality during long-term storage.

Benefits of technology

Saponin compounds effectively protect template nucleotides, maintaining high data quality and preventing interference with base recognition signals, even after multiple sequencing reactions, thus enhancing nucleic acid sequencing performance.

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Abstract

The present invention relates to the field of nucleic acid sequencing. In particular, the present invention relates to a scanning reagent comprising a saponin compound, a kit comprising the scanning reagent and a method for nucleic acid sequencing by using the scanning reagent.
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