Method and device for discriminating cells by electromagnetic wave scattering spectrum

JPWO2025028546A5Active Publication Date: 2026-04-14NARA INSTITUTE OF SCIENCE AND TECHNOLOGY +1
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Filing Date
2026-02-18
Publication Date
2026-04-14

AI Technical Summary

Technical Problem

Current methods for distinguishing tumor cells from normal cells, especially under an optical microscope, are challenging due to the difficulty in observing submicrometer-sized structures and protein denaturation, and existing techniques like light scattering spectroscopy and AI analysis have limitations in accuracy and applicability.

Method used

The method involves analyzing light scattering spectra using machine learning to differentiate normal and abnormal cells by extracting feature quantities from the spectral data, which are not limited by physical interpretations, allowing for the detection of subtle differences in cell structures that cannot be observed with optical microscopes.

Benefits of technology

This approach enables high-sensitivity and accurate discrimination of tumor cells, reducing reliance on pathologist expertise and improving diagnostic accuracy beyond conventional optical microscopy.

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Abstract

Provided is a method for using a sample containing cells collected from a patient to discriminate, with high sensitivity and high accuracy, normal cells and abnormal cells contained in the sample. A sample containing cells collected from a patient is irradiated with electromagnetic waves, an electromagnetic wave scattering spectrum from the cells in the sample is measured, and normal cells and abnormal cells are discriminated on the basis of the characteristics of the electromagnetic wave scattering spectrum. The discrimination uses a trained model in which the electromagnetic wave scattering spectra of normal cells and abnormal cells are trained. The sample may be a living cell, or may be a sample that is immobilized by an alcohol or formalin and dyed. The electromagnetic wave scattering spectrum may use either or both of a scattering spectrum obtained through Rayleigh scattering and a scattering spectrum obtained through Mie scattering.
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