Control method and apparatus for liquid chromatograph system

Abstract

Disclosed in the present invention are a control method and apparatus for a liquid chromatograph system. The liquid chromatograph system comprises a system control module and several liquid chromatographs. The method comprises: on the basis of a system control module, controlling data interconnection among several liquid chromatographs and controlling the several liquid chromatographs to regularly back up configuration information and operation information of each other; receiving an interrupt signal from a liquid chromatograph in use, wherein the interrupt signal comprises an instrument failure signal or a manual control signal; according to the interrupt signal, stopping the operation of the liquid chromatograph in use; and controlling a standby liquid chromatograph to continue a separation experiment on the basis of configuration information and operation information of the liquid chromatograph in use within the previous synchronization period. By means of operating a plurality of liquid chromatographs in a networking manner, configuration information and operation information of devices are synchronized and shared in real time, and when a device fails or the performance of the device cannot meet requirements of a separation experiment, the device is replaced with a standby device, and the standby device continues the separation experiment on the basis of configuration data and operation data of the previous device when the experiment is interrupted, thereby improving the data accuracy and the test stability when a device is replaced during an experiment.

Description

Liquid chromatograph system control method and device

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims priority to the Chinese patent application filed with the China Patent Office on June 16, 2023, with application number 2023107205069 and invention name “A Liquid Chromatography System Control Method and Device”, the entire contents of which are incorporated by reference into this application. Technical Field

[0003] The present invention relates to the field of liquid chromatography instrument control, and in particular to a liquid chromatography instrument system control method and device. Background Art

[0004] Intelligent liquid chromatographs are equipped with advanced chromatographic hardware and a computer program, the Liquid Chromatography Expert System, which incorporates extensive expertise and experience in chromatographic analysis methods. Its operation is precisely controlled by a computer, enabling conditional online qualitative analysis. During rapid scanning with the detector, spectral data is directly input into the computer. Chromatographic peaks are identified using chemometric techniques, along with chromatographic retention data. Artificial intelligence (AI) technology is applied to chromatographic analysis, inferring and judging based on the expertise and experience of chromatographic experts. This simulates the chromatographic expert's ability to solve complex problems requiring expert decision-making, providing expert-level solutions or decisions, and resolving challenges such as selecting chromatographic analysis conditions and qualitative analysis.

[0005] However, while existing intelligent liquid chromatographs offer a high degree of automation, they can also present new challenges. For example, a systemic failure can render the instrument inoperable, leading to sample failure and losses for the user. Alternatively, a customer lacking familiarity with the sample may need to adjust parameters mid-run, but the selected instrument may not meet the subsequent experimental requirements, resulting in sample failure and losses for the user.

[0006] Summary of the Invention

[0007] The purpose of the embodiments of the present invention is to provide a liquid chromatography system control method and device, which connects multiple liquid chromatographs to a network for operation, and shares the equipment configuration and operation information in real time and synchronously. When the equipment fails or its performance cannot meet the requirements of the separation experiment, it is replaced with another spare liquid chromatograph and the separation experiment is continued based on the configuration and operation data of the previous equipment when the experiment was interrupted, thereby improving the data accuracy and test stability of the replacement equipment during the separation experiment.

[0008] In order to solve the above technical problems, the first aspect of the embodiment of the present invention provides a liquid chromatography system control method,

[0009] The liquid chromatography system includes a system control module and several liquid chromatographs, including the following steps:

[0010] Based on the system control module, the system controls the data interconnection of several liquid chromatographs and regularly backs up configuration and operation information to each other;

[0011] receiving an interruption signal from the liquid chromatograph in use, wherein the interruption signal includes an instrument failure signal or a manual control signal;

[0012] stopping the operation of the liquid chromatograph in use according to the interrupt signal;

[0013] The standby liquid chromatograph is controlled to continue the separation experiment based on the configuration and operation information of the in-use liquid chromatograph in the previous synchronization cycle.

[0014] Furthermore, the configuration and operation information includes: flow rate, separation column type, sample loading amount, wavelength and / or separation gradient.

[0015] Furthermore, the system control module controls the data interconnection of several liquid chromatographs and regularly backs up configuration and operation information of each other, specifically including:

[0016] The liquid chromatograph is controlled to send the configuration and operation information to other liquid chromatographs in a broadcast form.

[0017] Furthermore, before receiving the interrupt signal of the liquid chromatograph in use, the method further includes:

[0018] Obtaining operating information of the liquid chromatograph in use;

[0019] comparing the parameter value in the operation information with the operation information parameter threshold value pre-stored in the system control module;

[0020] If the operating information parameter value exceeds the operating information numerical threshold, the in-use liquid chromatograph is controlled to stop operating, and the standby liquid chromatograph is started to continue the separation experiment based on the configuration and operating information in the previous data synchronization cycle;

[0021] If the operating information parameter value does not exceed the operating information parameter threshold, the liquid chromatograph in use is controlled to continue operating according to the current state.

[0022] Furthermore, before starting the standby liquid chromatograph to continue the separation experiment based on the configuration and operation information in the previous data synchronization cycle, the method further includes:

[0023] The configuration information of the standby liquid chromatograph is adjusted according to the configuration information of the in-use liquid chromatograph in a previous data period.

[0024] Accordingly, a second aspect of an embodiment of the present invention provides a liquid chromatograph system control device, wherein the liquid chromatograph system includes a system control module and a plurality of liquid chromatographs, including:

[0025] A data synchronization module, based on the system control module, controls the data interconnection of several liquid chromatographs and regularly backs up configuration and operation information of each other;

[0026] An interrupt signal receiving module, which is used to receive an interrupt signal from the liquid chromatograph in use, wherein the interrupt signal includes: an instrument failure signal or a manual control signal;

[0027] a first control module, configured to stop the operation of the liquid chromatograph in use according to the interrupt signal;

[0028] The second control module is used to control the standby liquid chromatograph to continue the separation experiment based on the configuration and operation information of the previous synchronization cycle of the in-use liquid chromatograph.

[0029] Furthermore, the configuration and operation information includes: flow rate, separation column type, sample loading amount, wavelength and / or separation gradient.

[0030] Furthermore, the data synchronization module is used to control the liquid chromatograph to send configuration and operation information to other liquid chromatographs in a broadcast form.

[0031] Furthermore, the liquid chromatograph system control device further comprises: a detection switching module, the detection switching module comprising:

[0032] an information acquisition unit, configured to acquire operating information of the liquid chromatograph in use;

[0033] a parameter comparison unit, configured to compare a parameter value in the operation information with an operation information parameter threshold value pre-stored in the system control module;

[0034] an equipment switching unit, configured to control the in-use liquid chromatograph to stop operating when the operating information parameter value exceeds the operating information numerical threshold, and to start the standby liquid chromatograph to continue the separation experiment based on the configuration and operating information in the previous data synchronization cycle;

[0035] The device switching unit is further configured to control the liquid chromatograph in use to continue operating according to a current state when the operating information parameter value does not exceed the operating information parameter threshold.

[0036] Furthermore, before starting the standby liquid chromatograph to continue the separation experiment based on the configuration and operation information in the previous data synchronization cycle, the device switching unit also adjusts the configuration information of the standby liquid chromatograph according to the configuration information in the previous data cycle of the liquid chromatograph in use.

[0037] Correspondingly, the third aspect of an embodiment of the present invention also provides an electronic device, comprising: at least one processor; and a memory connected to the at least one processor; wherein the memory stores instructions that can be executed by the one processor, and the instructions are executed by the one processor so that the at least one processor executes the above-mentioned liquid chromatography system control method.

[0038] Correspondingly, the fourth aspect of the embodiments of the present invention further provides a computer-readable storage medium on which computer instructions are stored, and when the instructions are executed by a processor, the above-mentioned liquid chromatography system control method is implemented.

[0039] The above technical solutions of the embodiments of the present invention have the following beneficial technical effects:

[0040] By networking multiple liquid chromatographs and sharing device configuration and operating information in real time, when a device fails or its performance cannot meet the requirements of the separation experiment, it can be replaced with another spare liquid chromatograph and the separation experiment can be continued based on the configuration and operating data of the previous device when the experiment was interrupted, thereby improving the data accuracy and test stability when replacing equipment during the separation experiment. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] 1 is a flow chart of a liquid chromatograph system control method according to an embodiment of the present invention;

[0042] FIG2 is a schematic diagram of a liquid chromatograph system architecture provided by an embodiment of the present invention;

[0043] 3 is a block diagram of a liquid chromatograph system control device module according to an embodiment of the present invention;

[0044] FIG4 is a block diagram of a detection switching module provided by an embodiment of the present invention.

[0045] Reference numerals: 1. Data synchronization module, 2. Interrupt signal receiving module, 3. First control module, 4. Second control module, 5. Detection switching module, 51. Information acquisition unit, 52. Parameter comparison unit, 53. Device switching unit. DETAILED DESCRIPTION

[0046] To make the objectives, technical solutions, and advantages of the present invention more clearly understood, the present invention will be further described in detail below in conjunction with specific embodiments and with reference to the accompanying drawings. It should be understood that these descriptions are merely exemplary and are not intended to limit the scope of the present invention. In addition, in the following description, descriptions of well-known structures and technologies are omitted to avoid unnecessary confusion of the concepts of the present invention.

[0047] 1 and 2 , a first aspect of an embodiment of the present invention provides a method for controlling a liquid chromatograph system. The liquid chromatograph system includes a system control module, which is respectively connected to data of a plurality of liquid chromatographs and synchronizes data at regular intervals, including the following steps:

[0048] Step S200: Based on the system control module, the system controls the data interconnection of several liquid chromatographs and periodically backs up configuration and operation information of each other.

[0049] Step S400: receiving an interruption signal from the liquid chromatograph in use, where the interruption signal includes an instrument failure signal or a manual control signal.

[0050] Step S600: stopping the operation of the liquid chromatograph according to the interrupt signal.

[0051] Step S800: Control the standby liquid chromatograph to continue the separation experiment based on the configuration and operation information of the active liquid chromatograph in the previous synchronization cycle.

[0052] This control method enables the network connection and integration of multiple intelligent liquid chromatographs of various models, automatically sharing information and data between instruments. If an instrument experiences a system failure and becomes inoperable, the user can move the sample to another instrument, which will automatically return to the state configured at the time of the failure and continue the remaining experiment. If a particular instrument model is found to be unable to meet requirements, the experiment can be proactively interrupted and then resumed on another intelligent liquid chromatograph within the network, allowing the user's experiment to continue.

[0053] Specifically, the configuration and operating information of the liquid chromatograph includes, but is not limited to, flow rate, separation column type, sample load, wavelength, and / or separation gradient. By backing up these parameters and data to another liquid chromatograph, if the active liquid chromatograph is interrupted, the other liquid chromatograph can continue the separation experiment based on the above configuration and operating information without affecting the overall process.

[0054] Furthermore, the system control module in step S200 controls the data interconnection of several liquid chromatographs and regularly backs up configuration and operation information to each other, specifically including:

[0055] Step S210 : Control the liquid chromatograph to send configuration and operation information to other liquid chromatographs in a broadcast form.

[0056] Furthermore, before receiving the interrupt signal of the liquid chromatograph in use in step S400, the method further includes:

[0057] Step S321, obtaining the operating information of the liquid chromatograph in use.

[0058] Step S322: Compare the parameter value in the operation information with the operation information parameter threshold pre-stored in the system control module.

[0059] Step S323: If the operation information parameter value exceeds the operation information value threshold, the active liquid chromatograph is controlled to stop running, and the standby liquid chromatograph is started based on the configuration and operation information in the previous data synchronization cycle to continue the separation experiment.

[0060] Step S324: If the operating information parameter value does not exceed the operating information parameter threshold, the liquid chromatograph in use is controlled to continue operating according to the current state.

[0061] Furthermore, before starting the standby liquid chromatograph to continue the separation experiment based on the configuration and operation information in the previous data synchronization cycle in step S323, the method further includes:

[0062] Step S323a: Adjust the configuration information of the standby liquid chromatograph according to the configuration information of the active liquid chromatograph in the previous data cycle.

[0063] In one embodiment of the present invention, based on the above control method, when a liquid chromatograph fails, the liquid chromatograph system operates as follows:

[0064] (1) A separation experiment is being conducted on the instrument SPMI1. A system failure occurs on the instrument SPMI1 and the experiment is stopped. The separation column on the instrument SPMI1 is removed and measures are taken to prevent sample loss.

[0065] (2) Select a new idle instrument of the same model, SPMI5, and log in to your account;

[0066] (3) Find the experiment you have not completed before and choose to continue the experiment on the instrument SPMI5;

[0067] (4) The instrument SPMI5 will find the previous experimental data and the status before the fault occurs in the historical records through the network. The instrument will automatically adjust the instrument to the same status according to the previous configuration information data (including: flow rate, separation column type, sample load, wavelength, separation gradient, etc.);

[0068] (5) Install the separation column that was previously removed from the instrument SPIM1 ​​and complete the experiment on the instrument SPMI5 according to the previous experimental method of the faulty instrument.

[0069] In another embodiment of the present invention, based on the above-described control method, when the performance of the liquid chromatograph fails to meet the requirements, the experiment can be proactively interrupted. Then, other intelligent liquid chromatographs in the network can obtain the configuration parameters and information status data of the experiment at the time of interruption through networking. The equipment adjusts to the experimental state before the interruption, and the user can modify the new configuration parameters as needed, and the interrupted experiment can be continued according to the new parameters. The specific operation process is as follows:

[0070] (1) Perform a separation experiment on the SPMI2 instrument. If the flow rate or pressure is found to be insufficient for the existing separation experiment, stop the experiment, remove the separation column from the SPMI2 instrument, and take appropriate measures to prevent sample loss.

[0071] (2) Select the new high-performance instrument SPMI7 and log in to your account;

[0072] (3) Find the experiment you have not completed before and choose to continue the experiment on the instrument SPMI7;

[0073] (4) The instrument will automatically obtain the previous experimental configuration data and the status information data at the time of interruption through networking, and automatically adjust to the same state. Then, the user can adjust the separation setting parameters;

[0074] (5) Install the separation column that was previously removed from the instrument SPIM2 and continue the interrupted experiment on the instrument SPMI7 according to the new parameters.

[0075] Accordingly, referring to FIG. 3 , a second aspect of an embodiment of the present invention provides a liquid chromatograph system control device, wherein the liquid chromatograph system includes a system control module and a plurality of liquid chromatographs, including:

[0076] Data synchronization module 1, based on the system control module, controls the data interconnection of several liquid chromatographs and regularly backs up configuration and operation information to each other;

[0077] An interrupt signal receiving module 2 is used to receive an interrupt signal from the liquid chromatograph in use, wherein the interrupt signal includes an instrument failure signal or a manual control signal;

[0078] A first control module 3, which is used to stop the operation of the liquid chromatograph in use according to the interrupt signal;

[0079] The second control module 4 is used to control the standby liquid chromatograph to continue the separation experiment based on the configuration and operation information of the previous synchronization cycle of the in-use liquid chromatograph.

[0080] Specifically, the configuration and operation information of the liquid chromatograph includes: flow rate, separation column type, sample load, wavelength and / or separation gradient.

[0081] Furthermore, the data synchronization module 1 is used to control the liquid chromatograph to send configuration and operation information to other liquid chromatographs in a broadcast form.

[0082] Further, referring to FIG. 4 , the liquid chromatograph system control device further includes: a detection switching module 5 , which includes:

[0083] An information acquisition unit 51 is used to acquire operating information of the liquid chromatograph in use;

[0084] a parameter comparison unit 52 for comparing the parameter value in the operation information with the operation information parameter threshold value pre-stored in the system control module;

[0085] The device switching unit 53 is used to control the liquid chromatograph in use to stop running when the operating information parameter value exceeds the operating information value threshold, and start the standby liquid chromatograph based on the configuration and operating information in the previous data synchronization cycle to continue the separation experiment;

[0086] The device switching unit 53 is further configured to control the liquid chromatograph in use to continue operating according to the current state when the operating information parameter value does not exceed the operating information parameter threshold.

[0087] Furthermore, before starting the standby liquid chromatograph to continue the separation experiment based on the configuration and operation information in the previous data synchronization cycle, the device switching unit 53 also adjusts the configuration information of the standby liquid chromatograph according to the configuration information in the previous data cycle of the active liquid chromatograph.

[0088] Correspondingly, the third aspect of an embodiment of the present invention also provides an electronic device, comprising: at least one processor; and a memory connected to the at least one processor; wherein the memory stores instructions that can be executed by a processor, and the instructions are executed by the processor so that the at least one processor executes the above-mentioned liquid chromatography system control method.

[0089] Correspondingly, the fourth aspect of the embodiments of the present invention further provides a computer-readable storage medium on which computer instructions are stored, and when the instructions are executed by a processor, the above-mentioned liquid chromatography system control method is implemented.

[0090] The embodiment of the present invention aims to protect a liquid chromatograph system control method and device. The liquid chromatograph system includes a system control module and several liquid chromatographs. The control method includes the following steps: based on the system control module, the system controls the data interconnection of several liquid chromatographs and regularly backs up the configuration and operation information of each other; receives an interrupt signal from the liquid chromatograph in use, the interrupt signal includes: an instrument failure signal or a manual control signal; according to the interrupt signal, stops the operation of the liquid chromatograph in use; controls the standby liquid chromatograph based on the configuration and operation information of the previous synchronization cycle of the liquid chromatograph in use to continue the separation experiment. The above technical solution has the following effects:

[0091] By networking multiple liquid chromatographs and sharing device configuration and operating information in real time, when a device fails or its performance cannot meet the requirements of the separation experiment, it can be replaced with another spare liquid chromatograph and the separation experiment can be continued based on the configuration and operating data of the previous device when the experiment was interrupted, thereby improving the data accuracy and test stability when replacing equipment during the separation experiment.

[0092] Those skilled in the art will appreciate that the embodiments of the present application can be provided as methods, systems, or computer program products. Therefore, the present application can adopt the form of a complete hardware embodiment, a complete software embodiment, or an embodiment in combination with software and hardware. Moreover, the present application can adopt the form of a computer program product implemented on one or more computer-usable storage media (including but not limited to magnetic disk storage, CD-ROM, optical storage, etc.) that contain computer-usable program code.

[0093] The present application is described with reference to the flow chart and / or block diagram of the method, device (system), and computer program product according to the embodiment of the present application. It should be understood that each flow process and / or box in the flow chart and / or block diagram and the combination of the flow process and / or box in the flow chart and / or block diagram can be realized by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, an embedded processing machine or other programmable data processing device to produce a machine, so that the instructions executed by the processor of the computer or other programmable data processing device produce a device for realizing the function specified in one flow chart flow or multiple flows and / or one box or multiple boxes of the block diagram.

[0094] These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing device to operate in a specific manner, so that the instructions stored in the computer-readable memory produce a product including an instruction device that implements the functions specified in one or more processes in the flowchart and / or one or more boxes in the block diagram.

[0095] These computer program instructions can also be loaded onto a computer or other programmable data processing device so that a series of operating steps are executed on the computer or other programmable device to produce a computer-implemented process, so that the instructions executed on the computer or other programmable device provide steps for implementing the functions specified in one or more processes in the flowchart and / or one or more boxes in the block diagram.

[0096] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit it. Although the present invention has been described in detail with reference to the above embodiments, ordinary technicians in the field should understand that the specific implementation methods of the present invention can still be modified or replaced by equivalents. Any modification or equivalent replacement that does not depart from the spirit and scope of the present invention should be covered by the scope of protection of the claims of the present invention.

Claims

1. A liquid chromatography system control method, characterized in that: The liquid chromatograph system includes a system control module and several liquid chromatographs, and includes the following steps: Based on the system control module, the data of several liquid chromatographs are controlled to be interconnected and the configuration and operation information are backed up to each other regularly; Receiving an interrupt signal from a liquid chromatograph in use, wherein the interrupt signal includes: an instrument failure signal or a manual control signal; According to the interrupt signal, stopping the operation of the liquid chromatograph in use; The standby liquid chromatograph is controlled to continue the separation experiment based on the configuration and operation information of the previous synchronization cycle of the in-use liquid chromatograph.

2. The liquid chromatography system control method according to claim 1, characterized in that: The configuration and operation information includes: flow rate, separation column type, sample loading amount, wavelength and / or separation gradient.

3. The liquid chromatography system control method according to claim 1, characterized in that: The system control module controls the data interconnection of several liquid chromatographs and backs up configuration and operation information to each other regularly, specifically including: The liquid chromatograph is controlled to send the configuration and operation information to other liquid chromatographs in a broadcasting form.

4. The liquid chromatography system control method according to any one of claims 1 to 3, characterized in that: Before receiving the interrupt signal of the liquid chromatograph in use, the method further comprises: Obtaining operation information of the liquid chromatograph in use; Comparing the parameter value in the operation information with the operation information parameter threshold value pre-stored in the system control module; If the operating information parameter value exceeds the operating information value threshold, the in-use liquid chromatograph is controlled to stop running, and the standby liquid chromatograph is started to continue the separation experiment based on the configuration and operating information in the previous data synchronization cycle; If the operation information parameter value does not exceed the operation information parameter threshold, the liquid chromatograph in use is controlled to continue operating according to the current state.

5. The liquid chromatography system control method according to claim 4, characterized in that: Before starting the standby liquid chromatograph to continue the separation experiment based on the configuration and operation information in the previous data synchronization cycle, the method further includes: The configuration information of the standby liquid chromatograph is adjusted according to the configuration information of the liquid chromatograph in use in a previous data cycle.

6. A liquid chromatography system control device, characterized in that: The liquid chromatograph system includes a system control module and several liquid chromatographs, including: A data synchronization module, based on the system control module, controls the data interconnection of several liquid chromatographs and regularly backs up configuration and operation information of each other; An interrupt signal receiving module, which is used to receive an interrupt signal of the liquid chromatograph in use, wherein the interrupt signal includes: an instrument failure signal or a manual control signal; A first control module, which is used to stop the operation of the liquid chromatograph in use according to the interrupt signal; The second control module is used to control the standby liquid chromatograph to continue the separation experiment based on the configuration and operation information of the previous synchronization cycle of the in-use liquid chromatograph.

7. The liquid chromatography system control device according to claim 6, characterized in that: The configuration and operation information includes: flow rate, separation column type, sample loading amount, wavelength and / or separation gradient.

8. The liquid chromatography system control device according to claim 6, characterized in that: The data synchronization module is used to control the liquid chromatograph to send configuration and operation information to other liquid chromatographs in a broadcast form.

9. The liquid chromatography system control device according to any one of claims 6 to 8, characterized in that: Also includes: A detection switching module, the detection switching module comprising: An information acquisition unit, used to acquire the operation information of the liquid chromatograph in use; a parameter comparison unit, configured to compare a parameter value in the operation information with a parameter threshold of the operation information pre-stored in the system control module; an equipment switching unit, which is used to control the in-use liquid chromatograph to stop running when the operating information parameter value exceeds the operating information value threshold, and start the standby liquid chromatograph to continue the separation experiment based on the configuration and operating information in the previous data synchronization cycle; The device switching unit is also used to control the liquid chromatograph in use to continue operating according to the current state when the operating information parameter value does not exceed the operating information parameter threshold.

10. The liquid chromatography system control device according to claim 9, characterized in that: Before starting the standby liquid chromatograph to continue the separation experiment based on the configuration and operation information in the previous data synchronization cycle, the device switching unit also adjusts the configuration information of the standby liquid chromatograph according to the configuration information in the previous data cycle of the liquid chromatograph in use.

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