Multi-sampling biopsy device, multi-sampling method, and sampling apparatus

Abstract

A multi-sampling biopsy device (1000), a multi-sampling method, and sampling apparatus (2000). The multi-sampling biopsy device (1000) comprises a forceps body mechanism (100), a telescopic member (150), and a guide member (160), wherein the forceps body mechanism (100) comprises a forceps cup (110) and a forceps holder (120), the forceps body mechanism (100) being provided with a collection chamber (130) and a storage chamber (140); the telescopic member (150) is provided with a collection portion (152) and a storage portion (153), and the telescopic member (150) can be driven to move in a reciprocating manner in the collection chamber (130) and the storage chamber (140), so as to make the collection portion (152) collect a tissue (300) and make the storage portion (153) store the tissue (300); and the guide member (160) is configured to guide the telescopic member (150) to move in a reciprocating manner in a proximal or distal direction relative to the forceps body mechanism (100).

Description

Multi-sampling biopsy device, multi-sampling method and sampling equipment

[0001] Related applications

[0002] This application claims priority to Chinese patent applications filed on June 13, 2023, with application number 202310698497.8 and titled “Multi-sampling biopsy device and multi-sampling method”; and filed on August 30, 2023, with application number 202311109750.8 and titled “Operating handle, sampling device and sampling method”, the entire contents of which are incorporated by reference into this application. Technical Field

[0003] The present application relates to the field of medical device technology, and in particular to a multi-sampling biopsy device, a multi-sampling method and a sampling apparatus. Background Art

[0004] Flexible endoscopic surgery, due to its minimally invasive nature and rapid recovery, is becoming an increasingly common surgical procedure in the digestive tract, urology, cardiopulmonary, and peripheral vascular fields. Preoperative endoscopic diagnosis often requires biopsy of suspected lesions for pathological analysis. Current methods primarily involve grasping the lesion using biopsy forceps with flexible shafts.

[0005] Currently, when biopsy forceps and similar medical devices are used, only one sampling can be completed with one insertion of the scope. However, in actual clinical applications, multiple sampling and acquisition of multiple tissues are often required. Therefore, when using traditional biopsy forceps for multiple sampling, the scope needs to be repeatedly withdrawn and inserted. This leads to many problems such as multiple single sampling, cumbersome operation, low surgical efficiency, long operation time, pain for patients, and susceptibility to infection.

[0006] Summary of the Invention

[0007] According to various embodiments of the present application, a multi-sampling biopsy device, a multi-sampling method, and a sampling apparatus are provided.

[0008] The present application provides a multi-sampling biopsy device, which includes: a clamp body mechanism, including a clamp cup and a clamp seat that are movably connected, and a collection chamber and a storage chamber that are adjacent and through-set are formed inside the clamp body mechanism, and the collection chamber is located on the distal side of the storage chamber; a telescopic member, arranged in the clamp body mechanism, the telescopic member is provided with a collection part and a storage part, and the collection part is located on the distal side of the storage part, and the telescopic member can be driven to move back and forth in the collection chamber and the storage chamber, thereby causing the collection part to collect tissue and the storage part to store tissue; and a guide member, arranged on the outer periphery of the telescopic member, for guiding the telescopic member to move back and forth relative to the clamp body mechanism in the proximal and distal directions; when the telescopic member is displaced toward the distal side, the distal end of the telescopic member can protrude beyond the distal end of the clamp cup to open the clamp cup, and cause the tissue at the collection part to be stopped in the clamp cup, so that the tissue stopped in the clamp cup is displaced toward the proximal side of the telescopic member to the storage part.

[0009] The present application provides a multi-sampling method, which adopts the aforementioned multi-sampling biopsy device, and the steps of the multi-sampling method include: S1: in an initial state, the distal end of the telescopic member is located in the forceps cup and close to the distal end of the forceps cup. When the multi-sampling biopsy device is located at the tissue to be collected, the forceps cup is driven to open, so that the collection part at the distal end of the telescopic member enters the tissue to be collected; S2: the forceps cup is driven to close so that the forceps cup removes the tissue; S3: the telescopic member is driven to move toward the distal side, so that the distal end of the telescopic member opens the forceps cup and the tissue removed by S2 is stopped in the forceps cup, and then the tissue stopped in the forceps cup is moved toward the proximal side of the telescopic member to the storage part, freeing up the collection part; S4: the telescopic member is driven to move in the proximal direction so that the telescopic member returns to the initial state, and at the same time, the tissue at the storage part follows the telescopic member to move in the proximal direction, so that the tissue at the storage part leaves the collection chamber and enters the storage chamber; at this time, one tissue sampling is completed; and S5: S1 to S4 are repeated to complete N tissue samplings.

[0010] The present application provides a sampling device, which includes: an operating mechanism; and the aforementioned multi-sampling biopsy device, wherein the clamp body mechanism and the telescopic member are respectively driven by the operating mechanism.

[0011] The present application provides an operating mechanism, which includes a handle body and multiple control members; the multiple control members are movably connected to the handle body, and each control member is connected to a driving member, which is used to connect to the distal component; wherein, each control member can reciprocate relative to the handle body in the distal and proximal directions, and each control member has a movement tendency to reset toward the distal side or toward the proximal side, and each control member can drive the corresponding driving member to move synchronously and thereby drive the distal component to move.

[0012] The present application also provides a sampling device, which includes: a distal component; the aforementioned operating mechanism, which is used to control the distal component; and a driving member, which connects the operating mechanism and the distal component.

[0013] The present application provides a sampling method, which is based on the aforementioned sampling device and includes the following steps: S10: in the initial state, the distal end of the telescopic member is located in the forceps cup and close to the distal end of the forceps cup. When the sampling device is located at the tissue to be collected, the first control member is driven to move toward the distal side, the forceps cup is driven to open, and the collection portion at the distal end of the telescopic member enters the tissue to be collected; S20: under the movement trend of resetting, the first control member moves toward the proximal side, the forceps cup is driven to close, and the forceps cup removes the tissue; S30: the second control member is driven to move toward the distal side, the telescopic member is driven to close, and the forceps cup is driven to remove the tissue; The distal end of the retracting member opens the forceps cup and the tissue removed in S20 is always stopped in the forceps cup, so that the tissue stopped in the forceps cup moves toward the proximal side of the telescopic member to the storage part, leaving the collection part empty; S40: under the resetting movement trend, the second control member moves toward the proximal side, so that the telescopic member returns to its initial state, and at the same time, the tissue at the storage part follows the telescopic member to move toward the proximal side, so that the tissue at the storage part leaves the collection chamber and enters the storage chamber; at this time, one tissue sampling is completed; and S50: S10 to S40 are repeated to complete N tissue samplings.

[0014] The details of one or more embodiments of the present application are set forth in the accompanying drawings and the description below. Other features, objects, and advantages of the present application will become apparent from the description, drawings, and claims. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to better describe and illustrate the embodiments and / or examples of the inventions disclosed herein, reference may be made to one or more of the accompanying drawings. The additional details or examples used to describe the accompanying drawings should not be considered to limit the scope of the disclosed inventions, the presently described embodiments and / or examples, and any of the best modes currently understood for these inventions.

[0016] FIG1 is a partial structural schematic diagram of a multi-sampling biopsy device according to one or more embodiments;

[0017] FIG2 is a schematic diagram of the overall structure of the clamp cup in FIG1 ;

[0018] FIG3 is a schematic diagram of the overall structure of a telescopic member according to one or more embodiments;

[0019] FIG4 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments;

[0020] FIG5 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments;

[0021] FIG6 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments;

[0022] FIG7 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments;

[0023] FIG8 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments;

[0024] FIG9 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments;

[0025] FIG10 is a first partial schematic diagram of a sampling device according to one or more embodiments;

[0026] FIG11 is a first partial cross-sectional view of an operating mechanism according to one or more embodiments;

[0027] FIG12 is a partial enlarged view of point A provided in FIG11;

[0028] FIG13 is a partial enlarged view of point B provided in FIG11;

[0029] FIG14 is a partial enlarged view of point C provided in FIG11;

[0030] 15 is a second partial cross-sectional view of an operating mechanism according to one or more embodiments;

[0031] 16 is a first partial cross-sectional view of a sampling device according to one or more embodiments;

[0032] FIG17 is a second schematic diagram of a clamp cup according to one or more embodiments;

[0033] FIG18 is a third schematic diagram of a clamp cup according to one or more embodiments;

[0034] 19 is a second schematic diagram of a telescopic member in a sampling device according to one or more embodiments.

[0035] Reference numerals: 1, distal end of forceps cup; 2, proximal end of forceps cup; 3, proximal end of collection chamber; 4, proximal end of forceps body mechanism; 5, proximal end of forceps seat; 6, proximal end of inner portion of forceps seat; 20, outer peripheral surface; 21, proximal end of driving member; 22, proximal end of spring tube; 23, distal end of rod-shaped connecting portion; 24, distal end of gripping rod; 25, proximal end of traction rope; 26, proximal end of control member; 27, distal end of control member; 28, distal end of operating mechanism; 30, distal end of sheath mechanism; 31, distal end of sheath;

[0036] 100, clamp body mechanism; 101, distal component; 110, clamp cup; 111, cup body; 1110, cup mouth; 1111, end cutting edge; 1112, side cutting edge; 1113, open mouth; 1114, storage chamber; 1115, drainage hole; 1116, fixing hole; 1117, hinge hole; 1118, guide groove; 112, connecting piece; 113, pin; 120, clamp seat; 121, tube seat; 122, connecting column; 130, collection chamber; 140, storage chamber; 141, Circumferentially sealed storage chamber; 150, telescopic member; 1502, distal end of telescopic member; 1503, proximal end of telescopic member; 151, barb structure; 1511, anti-slip protrusion; 1512, anti-slip depression; 152, collection portion; 1521, needle body; 153, storage portion; 154, first stopper; 1550, release member; 155, second stopper; 1551, connecting tube; 156, small-diameter disconnection portion; 160, guide member; 161, distal end of guide member; 162, proximal end of guide member;

[0037] 200, sheath tube mechanism; 210, sheath tube; 211, telescopic drive member; 212, opening and closing drive member; 213, spring tube; 214, support tube; 215, lubrication tube; 300, tissue; 301, first tissue; 302, second tissue;

[0038] 400, operating mechanism; 410, handle body; 411, grip rod; 412, connecting sleeve; 4121, connecting cavity; 413, grip ring; 4101, assembly cavity; 4102, guide slot; 4103, release space; 420, control member; 4201, first control member; 4202, second control member; 421, connecting hole; 422, bending section; 430, driving member; 4311, rod-shaped connecting member Connecting part; 4312, hooking section; 431, traction rope; 432, coupling member; 433, main rope; 440, limiting seat; 441, first limiting seat; 442, second limiting seat; 450, elastic member; 451, first elastic member; 452, second elastic member; 4401, second through hole; 4402, positioning groove; 4403, positioning column; 1000, multi-sampling biopsy device; 2000, sampling equipment. DETAILED DESCRIPTION

[0039] The present application will be described in more detail below with reference to the accompanying drawings. It should be noted that the description of the present application with reference to the accompanying drawings is merely illustrative and non-limiting. Different embodiments can be combined with each other to form other embodiments not shown in the following description.

[0040] It should be noted that when a component is referred to as being "fixed to" or "disposed on" another component, it may be directly on the other component or there may be a central component. When a component is considered to be "connected to" another component, it may be directly connected to the other component or there may be a central component at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in the specification of this application are for illustrative purposes only and do not represent the only implementation method.

[0041] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of such features. Throughout the description of this application, "plurality" means at least two, for example, two, three, etc., unless otherwise specifically defined.

[0042] In this application, unless otherwise expressly specified or limited, when a first feature is "above" or "below" a second feature, it can mean that the first feature is directly in contact with the second feature, or the first feature and the second feature are indirectly in contact through an intermediary. Furthermore, when a first feature is "above," "above," or "above" a second feature, it can mean that the first feature is directly above or diagonally above the second feature, or simply means that the first feature is higher in level than the second feature. When a first feature is "below," "below," or "below" a second feature, it can mean that the first feature is directly below or diagonally below the second feature, or simply means that the first feature is lower in level than the second feature.

[0043] Unless otherwise defined, all technical and scientific terms used in the specification of this application have the same meaning as commonly understood by those skilled in the art to which this application belongs. The terms used in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application. The term "and / or" used in the specification of this application includes any and all combinations of one or more of the relevant listed items.

[0044] It should be noted that, except for the non-sectional views of the telescopic member 150 and the forceps cup 110, Figures 4 through 8 are sectional views. To more clearly illustrate the movement of the telescopic member 150 and tissue 300 within the forceps cup 110, perspective is used. Figures 1 through 3 are normal views. Furthermore, the collection chamber 130, storage chamber 140, collection section 152, and storage section 153 are located in the corresponding positions within the dashed boxes.

[0045] It should be noted that the terms "distal" and "proximal" in this application are based on the doctor. The end closest to the doctor is the proximal end or the proximal portion, and the end away from the doctor is the distal end or the distal portion. The side facing the doctor is the proximal side or the proximal side, and the side facing away from the doctor is the distal side or the distal side. Furthermore, the distal and proximal directions represent two directions; the proximal-distal direction is parallel to the distal and proximal directions, and the proximal-distal direction does not specifically refer to forward or reverse directions.

[0046] Currently, when biopsy forceps and similar medical devices are used, only one sampling can be completed with one insertion of the scope. However, in actual clinical applications, multiple sampling and acquisition of multiple tissues are often required. Therefore, when using traditional biopsy forceps for multiple sampling, the scope needs to be repeatedly withdrawn and inserted. This leads to many problems such as multiple single sampling, cumbersome operation, low surgical efficiency, long operation time, pain for patients, and susceptibility to infection.

[0047] In order to solve the above technical problems, the present application proposes a multi-sampling biopsy device and a multi-sampling method. The present application includes the following advantages: multiple samplings can be completed with only one insertion of the mirror, without the need for repeated withdrawal and insertion of the mirror. It has many advantages such as multiple sampling, simplified operation, high surgical efficiency, greatly shortened time, reduced patient pain, hygiene and safety, and high biopsy accuracy. During the multiple sampling process, it also has the advantages of high sampling stability, accurate positioning, simple multi-sampling process, avoidance of misoperation, smooth and no jamming.

[0048] 1 to 9 , the present application provides a multi-sampling biopsy device 1000 , which may include a clamp mechanism 100 , a telescopic member 150 , and a guide member 160 .

[0049] Exemplarily, the clamp body 100 includes a movably connected clamp cup 110 and a clamp seat 120 . A collection chamber 130 and a storage chamber 140 are formed inside the clamp body 100 . The collection chamber 130 is located distally of the storage chamber 140 .

[0050] Exemplarily, a telescopic member 150 is disposed within the forceps mechanism 100. The telescopic member 150 includes a collection portion 152 and a storage portion 153, with the collection portion 152 located distally from the storage portion 153. The telescopic member 150 can be driven to move back and forth within the collection chamber 130 and the storage chamber 140, thereby causing the collection portion 152 to collect tissue 300 and the storage portion 153 to store tissue 300.

[0051] Illustratively, the collection portion 152 and the storage portion 153 may be disposed on the periphery of the telescopic member 150. The telescopic member 150 includes a distal end 1502 and a proximal end 1503. Illustratively, a portion of the collection portion 152 may be disposed on the distal end 1502. The periphery of the telescopic member 150 may refer to the radially outer periphery of the telescopic member 150. The periphery of the telescopic member 150 may encompass the entire length of the telescopic member 150, or may extend to the proximal and / or distal ends of the telescopic member 150.

[0052] The distal end and proximal end of the forceps cup 110 may be referred to as forceps cup distal end 1 and forceps cup proximal end 2; similarly, the distal end and proximal end of the telescopic member 150 may be referred to as telescopic member distal end 1502 and telescopic member proximal end 1503. Alternatively, the distal end of the forceps cup 110 may be referred to as the first distal end, and the distal end of the telescopic member 150 may be referred to as the second distal end.

[0053] For example, the guide member 160 is disposed on the outer periphery of the telescopic member 150 to guide the telescopic member 150 to move back and forth relative to the clamp body mechanism 100 in the distal and proximal directions. The guide member 160 can surround 360° along the circumference of the telescopic member 150 or surround a portion thereof; the guide member 160 can be discontinuous and have multiple sections.

[0054] The multi-sampling biopsy device 1000 has a distal end and a proximal end. When the telescopic member 150 is displaced distally relative to the forceps body 100, the distal end 1502 of the telescopic member protrudes beyond the distal end 1 of the forceps cup, expanding the forceps cup 110 and retaining tissue 300 at the collection portion 152 within the forceps cup 110. The retained tissue 300 then moves toward the proximal end 1503 of the telescopic member, into the storage portion 153. In other words, the distal movement of the telescopic member 150 relative to the tissue 300 effectively displaces the tissue 300 proximally toward the telescopic member 150, into the storage portion 153. The collection chamber 130 and the storage chamber 140 in the clamp body mechanism 100 of the present application are connected (regardless of whether the clamp cup 110 is open or closed), ensuring that the telescopic member 150 and the tissue 300 thereon can move back and forth smoothly and unimpeded within the clamp body mechanism 100; the guide member 160 ensures the stability and directionality of the displacement of the telescopic member 150; each sampling can prepare for the next sampling, and the tissue 300 obtained after multiple samplings is arranged in sequence on the telescopic member 150, which is convenient for the user to collect and mark.

[0055] Exemplarily, the interior of the forceps cup 110 includes at least a collection chamber 130 , and a storage chamber 140 is formed between the proximal end 3 of the collection chamber and the proximal end 5 of the forceps seat or near the proximal end 5 of the forceps seat, ensuring that the storage chamber 140 is large enough.

[0056] Illustratively, in the initial state, the position of the collecting cavity 130 corresponds to the collecting portion 152 of the telescopic member 150 , and the position of the storage cavity 140 corresponds to the storage portion 153 of the telescopic member 150 .

[0057] Exemplarily, the guide 160 is disposed within the caliper mechanism 100 .

[0058] Exemplarily, the guide 160 is disposed at the proximal end 6 of the clamp base or near the proximal end 5 of the clamp base.

[0059] Exemplarily, the forceps cup 110 includes at least a collection chamber 130 therein, and a storage chamber 140 is formed between the proximal end 3 of the collection chamber and the distal end 161 of the guide member.

[0060] Exemplarily, the guide member 160 is disposed on the outer periphery of the telescopic member 150 , and the outer periphery of the guide member 160 can be slidably connected to the interior of the caliper mechanism 100 .

[0061] Illustratively, the clamp mechanism 100 is connected with a first limiting member 154 located at the distal end of the guide member 160 , or / and a second limiting member 155 located at the proximal end of the guide member 160 .

[0062] Exemplarily, the telescopic member 150 is a needle-shaped body, and the distal end 1502 of the telescopic member is in the shape of a needle tip, which can improve the collection efficiency.

[0063] Illustratively, the outer periphery of the telescopic member 150 is provided with anti-slip protrusions 1511 and / or anti-slip recesses 1512 to ensure that the tissue 300 is stably fixed on the telescopic member 150 .

[0064] In some embodiments, the multi-sampling biopsy device 1000 also includes a sheath mechanism 200, the distal end 30 of the sheath mechanism is connected to the proximal end 4 of the clamp body mechanism, and includes a sheath 210. The sheath 210 is internally provided with a telescopic driving member 211 connected to the proximal end 1503 of the telescopic member, and an opening and closing driving member 212 connected to the proximal end 2 of the clamp cup, which can open and close the clamp cup 110.

[0065] Exemplarily, the telescopic member 150 and the telescopic driving member 211 are detachably connected to facilitate removing all samples after completing multiple samplings.

[0066] Illustratively, the telescopic member 150 and the telescopic drive member 211 are detachably connected via a release member 1550. Illustratively, the guide member 160 is disposed on the clamp mechanism 100, with the guide member proximal end 162 contacting the sheath distal end 31. The contact between the guide member 160 and the sheath 210 increases the stability of the guide member 160 and prevents it from loosening due to frequent reciprocating movement of the telescopic member 150.

[0067] In one embodiment of the present application, a multi-sampling biopsy device 1000 is provided, as shown in FIG. 1 to FIG. 9 , comprising:

[0068] The forceps mechanism 100 includes a hinged forceps cup 110 and a forceps base 120, which are formed with adjacent and continuous collection chambers 130 and storage chambers 140. The collection chamber 130 is located at the distal end of the storage chamber 140. The collection chamber 130 is used to accommodate newly collected tissue 300, and the storage chamber 140 is used to store collected tissue 300.

[0069] The telescopic member 150 is specifically a needle-like body with a needle-like distal end and a barbed structure 151 arranged on the periphery. The telescopic member 150 is disposed within the clamp body mechanism 100 and includes a collecting portion 152 and a storage portion 153. The collecting portion 152 is located distal to the storage portion 153. When the telescopic member 150 is driven, it can be moved back and forth within the collecting cavity 130 and the storage cavity 140, thereby causing the collecting portion 152 to collect tissue 300 and the storage portion 153 to store tissue 300.

[0070] The guide member 160 is fixedly connected to the proximal end of the clamp base 120, and the telescopic member 150 is slidably arranged through the guide member 160, so that the guide member 160 can guide the telescopic member 150 to move back and forth relative to the clamp body mechanism 100 in the distal and proximal directions;

[0071] The sheath mechanism 200 has a distal end connected to the proximal end of the forceps body mechanism 100, and the proximal end of the sheath mechanism 200 is connected to an operating mechanism 400, such as shown in FIG11 . The sheath mechanism 200 includes a sheath 210 that contacts the proximal end of the guide member 160. The sheath 210 includes a telescopic drive member 211 connected to the proximal end of the telescopic member 150 and an opening and closing drive member 212 connected to the proximal end of the forceps cup 110 for opening and closing the forceps cup 110. The proximal ends of the telescopic drive member 211 and the opening and closing drive member 212 are connected to the operating mechanism 400.

[0072] When the telescopic member 150 moves toward the distal side, the distal end of the telescopic member 150 can protrude from the distal end of the forceps cup 110 to open the forceps cup 110, and the tissue 300 at the collection portion 152 is stopped in the forceps cup 110, so that the tissue 300 moves toward the proximal end of the telescopic member 150 to the storage portion 153.

[0073] For example, in the initial state, regardless of whether the forceps cup 110 is open or closed, the distal end of the telescopic member 150 is placed inside the forceps cup 110 and close to the distal end of the forceps cup 110. After the forceps cup 110 is opened, the telescopic member 150 can directly enter the tissue 300 without the need for other operations, and the operation process is simple; then the forceps cup 110 bites the tissue 300. It can be seen that in the initial state, the distal end of the telescopic member 150 will not interfere with the opening and closing of the forceps cup 110; when the telescopic member 150 displaces toward the distal side, the distal end of the telescopic member 150 can protrude beyond the distal end of the forceps cup 110, and the length protruding from the distal end of the forceps cup 110 is ≤4 mm.

[0074] Specifically, regarding the clamp body mechanism 100, the clamp base 120 includes a tube base 121, which extends distally and is formed with two connecting posts 122. The clamp cup 110 comprises a pair of integral cup bodies 111 and connecting members 112. The two cup bodies 111 are each hingedly connected to the two connecting posts 122 via a connecting member 112 and a pin 113. The connected cup bodies 111, connecting members 112, and connecting posts 122 are located on the same side, ensuring unobstructed communication between the collection chamber 130 and the storage chamber 140. In the proximal and distal directions, the tube base 121 is longer than the connecting posts 122, ensuring that the circumferentially sealed storage chamber portion 141 is relatively long, making it less susceptible to contamination of the tissue 300.

[0075] Exemplarily, the cup mouth portion 1110 of the cup body 111 includes an end cutting edge 1111 at the distal end of the cup body 111, side cutting edges 1112 extending proximally from the end cutting edge 1111, and an opening 1113 at the proximal end of the cup body 111. The end cutting edge 1111 and the side cutting edges 1112 are arranged continuously. The opening 1113 is designed to allow for unobstructed flow between the collection chamber 130 and the storage chamber 140. The continuously arranged end cutting edges 1111 and the side cutting edges 1112 are sharp, leaving no gaps when engaged, and may be shaped like a knife edge or a sawtooth.

[0076] Regarding the collection chamber 130, the storage chamber 140, the collection portion 152, and the storage portion 153, specifically, the forceps cup 110 of this embodiment includes a collection chamber 130 (specifically, a portion of the space inside the forceps cup 110 located at the distal end of the forceps cup 110), and a storage chamber 140 is formed between the proximal end of the collection chamber 130 and the guide member 160; wherein the position of the collection chamber 130 corresponds to the collection portion 152 of the telescopic member 150, and the position of the storage chamber 140 corresponds to the storage portion 153 of the telescopic member 150.

[0077] In order to limit the reciprocating stroke of the telescopic member 150 , a first limiting member 154 located at the distal end of the guide member 160 and a second limiting member 155 located at the proximal end of the guide member 160 are fixedly connected to the telescopic member 150 .

[0078] Exemplarily, a first limiting member 154 is provided on at least the portion of the telescopic member 150 located on the distal side of the guide member 160. Exemplarily, the telescopic member 150 is provided with a first limiting member 154 located on the distal side of the guide member 160, and / or a second limiting member 155 located on the proximal side of the guide member 160. The first limiting member 154 and the second limiting member 155 can respectively limit the displacement stroke of the telescopic member 150 in one direction. When the first limiting member 154 and the second limiting member 155 are combined, the stroke of the telescopic member 150 can be limited in both directions, making it easier for the user to judge and control sampling, improving efficiency and ensuring sampling safety. The limitation in the distal direction can prevent the distal end 1502 of the telescopic member from protruding too much and damaging the inner layer of tissue, and the limitation in the proximal direction can prevent the tissue 300 from being squeezed or falling off by other components.

[0079] Exemplarily, the telescopic member 150 is detachably connected to the telescopic drive member 211 via a release member 1550 . In this embodiment, the release member 1550 is a connecting tube 1551 . Specifically, the connecting tube 1551 is provided on the portion of the telescopic member 150 located proximal to the guide member 160 . In this embodiment, the connecting tube 1551 is directly integrated with the second stopper 155 , which serves to limit the distal displacement of the telescopic member 150 . Thus, one component performs two functions. Combining the release member 1550 and the second stopper 155 into one simplifies the structure.

[0080] In one or more embodiments, the telescopic member 150 and the connecting tube 1551 are interference fit and can be pushed against each other in the opposite direction by the first limit member 154 and the guide member 160 until the connecting tube 1551 releases the telescopic member 150, or / and, the connecting tube 1551 and the telescopic driving member 211 are interference fit and can be pushed against each other in the opposite direction by the first limit member 154 and the guide member 160 until the telescopic member 150 is released by the release of the connecting tube 1551 and the telescopic driving member 211.

[0081] A multi-sampling method using the multi-sampling biopsy device 1000 includes the following specific steps:

[0082] S1: In the initial state, the distal end of the telescopic member 150 is located in the forceps cup 110 and close to its distal end. When the multi-sampling biopsy device 1000 is located at the tissue 300 to be collected, the forceps cup 110 is driven to open, allowing the collection portion 152 at the distal end of the telescopic member 150 to enter the tissue 300;

[0083] S2: driving the forceps cup 110 to close and remove the tissue 300;

[0084] S3: driving the telescopic member 150 to move toward the distal end, so that the distal end of the telescopic member 150 opens the forceps cup 110 and the tissue 300 removed in S2 is always stopped in the forceps cup 110, thereby causing the tissue 300 to move toward the proximal end of the telescopic member 150 to the storage portion 153, leaving the collection portion 152 empty;

[0085] S4: The telescopic member 150 is driven to move toward the proximal side to return to its initial state. At the same time, the tissue 300 follows the telescopic member 150 and moves toward the proximal side, so that the tissue 300 leaves the collection chamber 130 and enters the storage chamber 140. At this point, one tissue sampling is completed.

[0086] S5: Repeat S1 to S4 to complete N times of tissue sampling.

[0087] N is a positive integer greater than or equal to 2. Exemplarily, the first tissue 301 is located proximal to the second tissue 302 ; and the tissue 300 sampled later is located distal to the tissue 300 sampled earlier.

[0088] In this application, the tissues 300 obtained by multiple samplings are sequentially arranged on the telescopic member 150, which is easy to operate and does not require repeated opening and closing of the forceps cup 110, driving of the telescopic member 150, etc., thereby effectively avoiding misoperation and improving the efficiency and accuracy of multiple sampling.

[0089] In some implementations, after completing S5, operation S6 is performed:

[0090] S6: driving the telescopic member 150 to move toward the proximal side so that the first limiting member 154 and the guiding member 160 are opposed to each other until the telescopic member 150 is released. The user sequentially removes and collects the N tissue samples on the released telescopic member 150.

[0091] The tissues 300 obtained by multiple samplings are sequentially arranged on the telescopic member 150, making it convenient for the user to collect and mark them.

[0092] 10 , the present application provides a sampling device 2000, which may include an operating mechanism 400 and a multi-sampling biopsy device 1000. The multi-sampling biopsy device 1000 may be the multi-sampling biopsy device 1000 of the aforementioned embodiment.

[0093] The jaw mechanism 100 and the telescopic member 150 are respectively driven by the operating mechanism 400. For example, the sampling device 2000 further includes a driving member 430, and the multi-sampling biopsy apparatus 1000 is driven by the operating mechanism 400 via the driving member 430.

[0094] The sampling device 2000 of the present application can achieve multiple sample sampling in a single entry and exit.

[0095] 10 , the present application provides an operating mechanism 400 , which has the following advantages: enabling multiple sample sampling in a single entry and exit, eliminating the need for doctors to frequently enter and exit, improving operational efficiency, shortening surgical time, reducing patient pain, and improving sampling accuracy.

[0096] The operating mechanism 400 of the present application is a structure that can independently control the movement of the distal component 101, enabling continuous operation, such as continuous sampling. This allows for rapid completion of multiple samplings from the same lesion or biopsy during a single entry and exit, thereby improving operational efficiency, reducing surgical time, and alleviating patient pain. For example, the distal component 101 can be the forceps cup 110 or the telescopic member 150.

[0097] Please refer to Figure 10. The present application provides an operating mechanism 400, which can be an operating handle. The operating mechanism 400 includes a handle body 410 and a plurality of control members 420. The plurality of control members 420 are all movably connected to the handle body 410. Each control member 420 is connected to a drive member 430, and the drive member 430 is used to connect to the distal component 101. Among them, each control member 420 can reciprocate relative to the handle body 410 along a first direction, and each control member 420 has a movement tendency to reset toward one side along the first direction. Each control member 420 can drive the corresponding drive member 430 to move synchronously and thereby drive the distal component 101 to move. Among them, the direction in which the distal end and the proximal end of the handle body 410 are located is the first direction, also known as the distal-proximal direction.

[0098] It is understood that the arrangement of multiple control members 420 and corresponding drive members 430 satisfies the motion control of the distal component 101. During this process, each control member 420 can independently reciprocate in a first direction relative to the handle body 410, and each control member 420 has a tendency to independently reset toward one side along the first direction, so that after each movement, the control member 420 can independently and automatically return to its initial state; that is, each control member 420 can operate independently without interfering with or affecting each other, thereby ensuring that the distal component 101 corresponding to each control member 420 does not interfere with each other and can continue to operate. Therefore, when one of the distal components 101 is used as a sampling structure, such as a sampling needle, multiple operations can be performed during a single entry into the lesion area to obtain multiple samples, eliminating the need for the doctor to frequently enter and exit the human body, improving operational efficiency, reducing surgical time, and alleviating patient pain.

[0099] Referring to Figures 10 and 11 , multiple control members 420 are illustratively arranged at intervals along a first direction. This arrangement allows the multiple control members 420 to be distributed along their respective movement paths relative to the handle body 410, reducing force components in other directions and facilitating control. Furthermore, this arrangement fully utilizes the space within the handle body 410 along the first direction while reducing space in other directions. In particular, when the first direction is the axial direction of the handle body 410, this reduces the radial space occupied by the operating mechanism 400 along the handle body 410. In alternative embodiments, the multiple control members 420 may also be arranged at intervals along the radial direction of the handle body 410.

[0100] Referring to Figures 11 and 12 , since the multiple control members 420 extend in a first direction (i.e., the direction of movement, which can also be the axial direction of the handle body 410 ), in order to reduce interference between the driving member 430 and the control member 420, at least the control member 420 located near the distal end is configured with a first through-hole for guiding the driving member 430 corresponding to the control member 420 located near the proximal end. This not only ensures that the driving member 430 corresponding to each control member 420 extends in the first direction, shortening the transmission path, but also utilizes the first through-hole to guide the movement of the driving member 430.

[0101] Furthermore, the cross section of each control member 420 along the first direction is arranged in an "I" shape, which is convenient for the doctor to hold and operate.

[0102] Referring to Figures 10 and 11 , in some specific embodiments, there are two control members 420, namely a first control member 4201 and a second control member 4202. For example, the first control member 4201 is connected to the jaws, and the second control member 4202 is connected to the sampling needle. The first control member 4201 corresponds to the opening and closing driver 212 to open and close the jaws; the second control member 4202 corresponds to the retracting driver 211 to retract the sampling needle.

[0103] Take the direction of the distal and proximal ends of the handle body 410 as an example, which is the first direction. The first control member 4201 is located near the distal end, and the second control member 4202 is located near the proximal end. At this time, the first control member 4201 is configured with a first through-hole to guide the telescopic drive member 211 to pass through. The first control member 4201 can move toward the distal end to drive the jaws to open via the opening and closing drive member 212; and the first control member 4201 can have a tendency to move toward the proximal end to drive the jaws to close via the opening and closing drive member 212. The second control member 4202 moves toward the distal end to drive the sampling needle out of the jaws via the telescopic drive member 211; and the second control member 4202 has a tendency to move toward the proximal end to drive the sampling needle back via the telescopic drive member 211. This is just an example.

[0104] Please continue to refer to Figure 11. Further, the distal end of each control member 420 is connected to an elastic member 450, and the elastic member 450 is used to drive the corresponding control member 420 to reset toward the proximal end. The elastic member 450 is connected between the corresponding control member 420 and the handle body 410. The movement of the control member 420 toward the distal end causes the elastic member 450 to deform, thereby applying a force toward the proximal end, so that the control member 420 has a movement tendency to move toward the proximal end and reset; that is, in this case, the elastic member 450 can be a compression spring. In other embodiments, the proximal end of the control member 420, i.e., the proximal end 26 of the control member, can be connected to the elastic member 450. In this case, the elastic member 450 can be a tension spring; or, elastic members 450 are provided at both the proximal end and the distal end 27 of the control member 420, with the proximal end being a tension spring and the distal end being a compression spring.

[0105] In yet another embodiment, the control member 420 may move toward the proximal end to drive the distal member 101 to operate, and move toward the distal end to drive the distal member 101 to reset. In this case, the elastic member 450 is used to drive the corresponding control member 420 to reset toward the distal end to ensure the reset of the distal member 101. This is only an example, and the specific configuration needs to be adjusted according to the actual structure of the distal member 101.

[0106] It should be noted that the aforementioned terms "close to the proximal end" and "close to the distal end" refer to the relative positions of the multiple control members 420. For example, as shown in FIG10 , the second control member 4202 is closer to the proximal end than the first control member 4201, and the first control member 4201 is closer to the distal end than the second control member 4202. The first control member 4201 is configured with a first through hole for receiving the telescopic drive member 211.

[0107] In other embodiments, when there are three control members, they are divided into a first control member, a second control member, and a third control member. The second and third control members are closer to the distal end than the first control member, and the third control member is closer to the distal end than the second control member. Conversely, the second and first control members are closer to the proximal end than the third control member, and the first control member is closer to the proximal end than the second control member. In this case, both the second and third control members are provided with a first through hole. The first through hole in the second control member is used to pass through the drive member corresponding to the first control member, and the first through hole in the third control member is used to pass through the drive members corresponding to the first and second control members.

[0108] It should also be noted that when the clamps and sampling needle enter the human body, the impact on the patient's lesion area must be considered. If the clamps are opened for entry, the wound will be damaged, causing discomfort to the patient. Moreover, if the sampling needle extends too far relative to the clamps, the clamps may be positioned too far back relative to the lesion area, making sampling inconvenient. Therefore, in actual use, the clamps are closed, and the sampling needle is positioned far back relative to the clamps, which can be used as the initial position.

[0109] Continuing with FIG11 , in an optional embodiment, at least one limit seat 440 is provided on the handle body 410, and each control member 420 corresponds to at least one limit seat 440, and each limit seat 440 and each control member 420 are spaced apart along the first direction. In other words, each control member 420 corresponds to a limit seat 440, so as to limit the movement of the control member 420 and prevent excessive movement of the distal member 101. Furthermore, due to the limiting effect of the limit seat 440, interference between the movement of the various control members 420 can be avoided. The various control members 420 and the limit seats 440 are arranged in an alternating manner, and each limit seat 440 is located on the side closer to the distal end relative to its corresponding control member 420. In this way, while ensuring that each control member 420 is limited in its movement toward the distal end, interference between any two adjacent control members 420 and the movement of the corresponding distal member 101 is avoided, ensuring independent operation of each distal member 101.

[0110] In some specific embodiments, the first control member 4201 corresponds to the first limit seat 441, which is located at the distal end of the first control member 4201, and the second control member 4202 corresponds to the second limit seat 442, which is located at the distal end of the second control member 4202, so as to limit the distal movement of the first control member 4201 and the second control member 4202. In this way, the corresponding jaws can be prevented from opening too wide, thereby affecting the lesion area and causing discomfort to the patient, and the sampling needle can be prevented from moving too far and being positioned outside the lesion area. In addition, the first control member 4201 and the second control member 4202 can be prevented from interfering with each other and affecting the operation of the jaws and the sampling needle.

[0111] Please refer to Figures 11, 13 and 14. Furthermore, since each limit seat 440 is located near the distal end relative to the corresponding control member 420, a second through-hole 4401 is constructed on each limit seat 440 to guide the corresponding driving member 430 to pass through the second through-hole 4401 to avoid interference. Moreover, such a setting can also serve as a movement guide for the movement of each driving member 430. In an alternative embodiment, precisely because each control member 420 has a reciprocating motion along the first direction relative to the handle body 410, the limit seat 440 can also be located near the proximal end of the corresponding control member 420, or a limit seat 440 is provided at both the proximal end and the distal end of each control member 420. At this time, taking the first control member 420 located at the proximal end as a reference, all the limit seats 440 located on the distal side of the control member 420 need to be provided with a second through hole 4401, and the remaining control members 420 all need to be provided with a first through hole to guide the driving member 430 corresponding to the proximal control member 420 to pass through.

[0112] Referring to Figures 13 and 14 , in actual use, when the control member 420 needs to be reset toward the proximal end, the stopper 440 mounted at the distal end of the control member 420 can serve as a base for mounting the elastic member 450. That is, the axial direction of the elastic member 450 is aligned with the first direction, and the two ends of the elastic member 450 are respectively connected to the corresponding control member 420 and the stopper 440. At this time, each stopper 440 is configured with a positioning groove 4402 on one end surface facing the corresponding control member 420, and one end of the corresponding elastic member 450 can be inserted into the positioning groove 4402 to position the elastic member 450 during assembly. In a replaceable embodiment, a positioning column 4403 may be constructed on one end face of each limit seat 440 facing the corresponding control member 420, and the corresponding elastic member 450 may be sleeved on the positioning column 4403; or, it may be a combination of the positioning groove 4402 and the positioning column 4403, in which case the positioning column 4403 is located in the positioning groove 4402, and the elastic member 450 is sleeved on the outside of the positioning column 4403 and partially located in the positioning groove 4402.

[0113] The first control member 4201 corresponds to the first elastic member 451, which is connected between the first control member 4201 and the first limiting seat 441. The second control member 4202 corresponds to the second elastic member 452, which is connected between the second control member 4202 and the second limiting seat 442. The structure on the first limiting seat 441 for positioning and assembling the first elastic member 451 and the structure on the second limiting seat 442 for positioning and assembling the second elastic member 452 can be the same or different, as long as they meet the requirements for positioning and assembling the corresponding elastic member 450.

[0114] Please continue to refer to Figures 10 and 11. In an optional embodiment, a release space 4103 is constructed on the handle body 410 on the side of at least one control member 420 toward the proximal end, providing space for the control member 420 to move when the distal component 101 is released relative to the corresponding drive member 430. In actual use, taking Figure 11 as an example, the second control member 4202 is connected to the sampling needle via the telescopic drive member 211. The sampling needle needs to be released relative to the telescopic drive member 211 to facilitate the collection of samples on the sampling needle. At this time, the second control member 4202 is required to drive the telescopic drive member 211 to move toward the proximal end to release the sampling needle. Therefore, the partial area on the handle body 410 located proximal to the second control member 4202 can serve as the release space 4103. The specific release method will be detailed in the subsequent content.

[0115] As shown in Figures 11 and 12, illustratively, each control member 420 is constructed with a connecting hole 421, and the proximal portion of each driving member 430, that is, the proximal end 21 of the driving member, can be directly connected to the hole wall of the connecting hole 421 to meet the driving of the driving member 430 by the control member 420. The direct connection method simplifies the assembly steps and improves assembly efficiency. In other embodiments, the proximal portion of each driving member 430 can be indirectly connected to the hole wall of the connecting hole 421, that is, the driving member 430 and the corresponding control member 420 can be connected to form an integral structure through a transition component to achieve the driving of the driving member 430 by the control member 420. With such a setting, when one of the control member 420 and the driving member 430 is damaged, it can be repaired by disassembling the transition component, thereby improving protection.

[0116] In an optional embodiment, the proximal portion of each driver 430 is connected to a rod-shaped connecting portion 4311, which is inserted into the connecting hole 421 of the corresponding control member 420 via the rod-shaped connecting portion 4311; that is, the driver 430 is indirectly connected to the corresponding control member 420. Furthermore, the rod-shaped connecting portion 4311, due to its certain structural rigidity, can guide the movement of the driver 430. Specifically, the rod-shaped connecting portion 4311 can be a hollow structure, with one end inserted into the connecting hole 421 and the other end connected to the driver 430.

[0117] Please refer to Figures 11 and 12. Furthermore, the connecting hole 421 is constructed with a bending section 422 extending along the second direction, and the rod-shaped connecting part 4311 is constructed with a hook section 4312, and the hook section 4312 is inserted into the bending section 422. The second direction is angled with the first direction; or the extension direction of the bending section 422 is angled or non-parallel to the distal and proximal directions. At this time, the second direction can be the radial direction of the handle body 410, that is, the connecting hole 421 is set in a "T" shape or an "L" shape. Therefore, such a setting is equivalent to axially limiting the connection between the rod-shaped connecting part 4311 and the connecting hole 421 to prevent the two from axially disengaging during movement. The bending section 422 can be a circular arc groove with the center located on the axis of the connecting hole 421, or it can be a circular hole. In an alternative embodiment, the end of the rod-shaped connecting portion 4311 is plugged into the connecting hole 421 and positioned by the friction between the outer wall of the rod-shaped connecting portion 4311 and the hole wall of the connecting hole 421; of course, both can be provided with cooperating rough textures to improve connection reliability.

[0118] Furthermore, each elastic member 450 can be sleeved on the outer side of the corresponding rod-shaped connecting portion 4311 .

[0119] In actual use, taking the first control member 4201 as an example, since the first control member 4201 is located at the distal end of the second control member 4202, the connecting hole 421 in the first control member 4201 can also be configured as a through hole extending in the first direction. The telescopic driver 211 connected to the second control member 4202 can then pass through the connecting hole 421 and connect to the distal component 101. Alternatively, the first control member 4201 can be provided with a first through hole and a connecting hole 421, spaced apart from each other. Alternatively, the first through hole and the connecting hole 421 can communicate with each other, meaning that the first control member 4201 is configured with a through hole extending in the first direction, which serves both to connect with the corresponding rod-shaped connecting portion 4311 and to allow the telescopic driver 211 to pass through. In this case, the corresponding bent section 422 is located in the middle of the through hole, near the proximal end of the first control member 4201, thus forming a cross shape.

[0120] Continuing to refer to Figures 13 and 14, illustratively, when the driving member 430 is connected to the corresponding control member 420 via the rod-shaped connecting portion 4311, with respect to the stopper seat 440, the end of the rod-shaped connecting portion 4311 that is distal to the control member 420, i.e., the distal end 23 of the rod-shaped connecting portion, is inserted into the corresponding stopper seat 440. Because the stopper seat 440 is configured with a second through-hole 4401 for guiding the driving member 430 therethrough, the rod-shaped connecting portion 4311 can be inserted into the second through-hole 4401. In this manner, the ends of the rod-shaped connecting portion 4311 are respectively constrained by the walls of the connecting hole 421 and the second through-hole 4401. This not only guides the movement of the rod-shaped connecting portion 4311 with the control member 420, but also limits the assembly of the rod-shaped connecting portion 4311, minimizing shaking or displacement of the rod-shaped connecting portion 4311 and improving operational accuracy.

[0121] Please refer to Figures 10 and 11. As some of the embodiments, the handle body 410 includes a gripping rod body 411. The gripping rod body 411 is constructed with an assembly cavity 4101 and a guide groove 4102 connected to the assembly cavity 4101. The guide groove 4102 passes through the outer peripheral surface 20 of the handle body 410. The driving member 430 is installed in the assembly cavity 4101. Parts of each control member 420 pass through the guide groove 4102 and extend into the assembly cavity 4101 to connect with the corresponding driving member 430. Each control member 420 is movably connected to the gripping rod body 411.

[0122] When the control member 420 moves relative to the handle body 410 under the action of an external force, the portion of the control member 420 located within the guide slot 4102 can move within the guide slot 4102, thereby guiding the movement of the control member 420. Furthermore, the arrangement of the assembly cavity 4101 can protect the driver 430, preventing damage to the driver 430 and potentially affecting the distal component 101. With respect to the gripping rod 411, the aforementioned stopper 440 can be installed within the assembly cavity 4101, with a portion of the stopper 440 extending from the guide slot 4102. Furthermore, the rod-shaped connecting portion 4311 is located within the assembly cavity 4101, connecting to the control member 420 and the driver 430.

[0123] As shown in Figures 10, 11, 13, and 15, the handle body 410 further includes a connecting sleeve 412 connected to the distal end of the gripping rod 411. The connecting sleeve 412 is configured with a connecting cavity 4121 that communicates with the assembly cavity 4101. Each driver 430 can extend from the assembly cavity 4101 and the connecting cavity 4121 to facilitate connection to the distal component 101. The provision of the connecting sleeve 412 not only facilitates the integration of the handle body 410 with other structures, but also effectively extends the length of the handle body 410, further facilitating the integration of the driver 430 with the control member 420, and even allowing for the provision of multiple sets. Furthermore, a stopper 440 can be provided at the end of the connecting sleeve 412 facing the gripping rod 411 to facilitate the assembly of the elastic member 450 or to limit the movement of the distal control member 420. For example, the stopper 440 can serve as a first stopper 441 that mates with the first control member 4201.

[0124] During actual use, the handle body 410 further includes a gripping ring 413 for the user to grip, thereby facilitating application of force to each control member 420 .

[0125] Please refer to Figure 13. In an optional embodiment, the distal end of the gripping rod body 411, i.e., the distal end 24 of the gripping rod body, is provided with a clamping portion, and the connecting sleeve 412 is sleeved on the outer periphery of the clamping portion. It can be understood that the provision of the clamping portion is utilized to facilitate adaptation with the handle body 410 and other structures, and to facilitate assembly and disassembly. The clamping portion includes a plurality of clamping plates arranged at intervals around the axis of the gripping rod body 411, and a notch is constructed between any two adjacent clamping plates to facilitate deformation of each clamping plate and coordination with other structures. Specifically, a fixing tube is fixed inside the clamping portion to adapt to other structures through the fixing tube, and the driving member 430 passes through the fixing tube to connect with the distal component 101.

[0126] In some embodiments, the fixing tube, while providing connection to other structures, can also be used to limit the distal movement of the distal control member 420 (e.g., the first control member 4201). In this case, the fixing tube can serve as a limit seat 440, achieving the dual functions of connection and limit, thereby simplifying the internal structure of the operating mechanism 400. For example, an elastic member 450 (i.e., a first elastic member 451) can be connected between the fixing tube and the first control member 4201 to ensure the normal repositioning of the first control member 4201. In this case, the fixing tube serves as the first limit seat 441. To ensure stable assembly of the first elastic member 451, a positioning post 4403 is protruded from the proximal end of the fixing tube, and the end portion of the first elastic member 451 is sleeved on the outside of the positioning post 4403.

[0127] 10, 11, and 15, illustratively, the distal end of the operating mechanism 400, i.e., the distal end 28 of the operating mechanism, is connected to the sheath 210, and each driver 430 is disposed within the sheath 210. In other words, by utilizing the arrangement of the sheath 210, the radial direction of each driver 430 can be limited, so that each driver 430 can move only in the axial direction as much as possible to act on the corresponding distal component 101.

[0128] Referring to Figures 11 and 16 , in actual use, each driver 430 includes a traction rope 431. One end of each traction rope 431 is connected to the corresponding control member 420, and the other end is connected to the corresponding distal member 101. The distal member 101 only has a single operating head, such as a sampling needle, which only needs to drive the sampling needle to extend or retract along its own axis. When some drivers 430 include multiple traction ropes 431, the proximal ends of the multiple traction ropes 431, i.e., the proximal ends 25 of the traction ropes, are each connected to a control member 420. Alternatively, a main rope 433 is connected to the proximal ends of the multiple traction ropes 431 via a coupling 432, and the proximal end of the main rope 433 is connected to a control member 420. This arrangement not only simplifies the structure but also reduces interference in movement between the various drivers 430.

[0129] As shown in FIG15 , for example, a partial drive member 430 includes two traction ropes 431 . In this case, one end of each traction rope 431 can converge at a rod-shaped connecting portion 4311 , connecting to a corresponding control member 420 . The other end of each traction rope 431 can be connected to two operating heads of the distal component 101 . For example, a clamp includes two clamp cups 110 , with each traction rope 431 connected to a clamp cup 110 to facilitate opening and closing of the clamp. As shown in FIG8 , in an alternative embodiment, the two traction ropes 431 can converge at a main rope 433 via a coupling 432 , which is then connected to a corresponding control member 420 via the main rope 433 .

[0130] As shown in FIG15 , in an optional embodiment, the sheath 210 includes a spring tube 213, the proximal end of which, namely, the proximal end 22 of the spring tube, is connected to the handle body 410 via a support tube 214. It is understood that the spring tube 213, due to its inherent flexibility, can be inserted deeply into the human body, facilitating sampling operations. Furthermore, the spring tube 213 can limit the radial direction of the driver 430, thereby preventing radial deflection during movement of the driver 430 and ensuring the accuracy of movement of each driver 430. The support tube 214 is sleeved onto the outside of the spring tube 213 and is located at the proximal end of the spring tube 213. When the proximal end of the spring tube 213 is inserted into the fixed tube for assembly, the support tube 214 extends into the connecting cavity 4121 of the connecting sleeve 412 and engages with the connecting sleeve 412. During actual assembly, one end of the spring tube 213 extends into the assembly cavity 4101 through the connecting cavity 4121 of the connecting sleeve 412 and is inserted into the fixing tube to achieve the connection between the sheath tube 210 and the handle body 410 .

[0131] Furthermore, the sheath tube 210 also includes a lubrication tube 215. The lubrication tube 215 and the spring tube 213 are sequentially arranged from the inside to the outside, that is, the lubrication tube 215 is located inside the spring tube 213, and the spring tube 213 is located outside the lubrication tube 215. Each driver 430 is installed within the lubrication tube 215. The provision of the lubrication tube 215 ensures smooth axial movement of each driver 430, reducing the problem of movement blockage.

[0132] Illustratively, the present application provides a sampling device 2000, which includes a distal component 101 and an operating mechanism 400 for controlling the distal component 101. The sampling device 2000 is easy to operate, and the operating mechanism 400 can be used to control the distal component 101 multiple times during one insertion.

[0133] Referring to Figures 1 to 19 , one embodiment of the present application further provides a sampling device 2000, comprising the aforementioned operating mechanism 400, a distal component 101, and a drive member 430 connected to the operating mechanism 400 and the distal component 101. The distal component 101 includes a jaw body 100, a telescopic member 150, and a guide member 160. Specifically, the jaw body 100 includes a jaw base 120 and a jaw cup 110 movably connected to the jaw base 120. The jaw body 100 internally defines a collection chamber and a storage chamber, which are adjacent and interconnected. The collection chamber is located distally to the storage chamber. The telescopic member 150 is disposed within the jaw body 100 and includes a collection portion and a storage portion. The collection portion is located distally to the storage portion. The telescopic member 150 is capable of reciprocating within the collection chamber and the storage chamber, enabling the collection portion to collect tissue and the storage portion to store tissue. The guide member 160 is disposed on the outer periphery of the telescopic member 150 and is used to guide the reciprocating movement of the telescopic member 150 relative to the clamp mechanism 100 in the distal and proximal directions.

[0134] Exemplarily, the forceps cup 110 is connected to the corresponding forceps cup control member via a forceps cup traction member, and the telescopic member 150 is connected to the corresponding telescopic control member via a telescopic traction member. The telescopic member 150 is configured to move in response to the movement of the telescopic control member, and the forceps cup 110 is configured to open and close in response to the movement of the forceps cup control member. At the same time, the telescopic member 150 can move toward the distal end to open the forceps cup 110, and the sample tissue on the telescopic member 150 can be moved to the storage portion of the telescopic member 150 under the stop action of the forceps cup 110. It should be added that, in order to meet the uniformity of the description, the forceps cup traction member mentioned above is the opening and closing drive member 212, the forceps cup control member is the first control member 4201, the telescopic traction member is the telescopic drive member 211, and the telescopic control member is the second control member 4202. In addition, the opening and closing mentioned above refers to opening and closing.

[0135] In actual use, when the telescopic member 150 moves toward the distal end, the distal end of the telescopic member 150 can protrude from the distal end of the forceps cup 110 to expand the forceps cup 110, and the tissue collected at the collection portion of the telescopic member 150 will be stopped in the forceps cup 110; and as the telescopic member 150 continues to move toward the distal end, the tissue on the telescopic member 150 will move toward the proximal end of the telescopic member 150 under the stopping action of the forceps cup 110 to the storage portion of the clamp body mechanism 100 for storage. In this way, multiple sample tissues can be sampled by multiple movements of the telescopic member 150 and multiple openings and closings of the forceps cup 110, and the sample tissues sampled each time are stored in the storage portion of the telescopic member 150 and the storage cavity of the forceps body mechanism 100.

[0136] As shown in Figures 16 to 18 and Figure 2, the clamp body mechanism 100 exemplarily includes at least two clamp cups 110, at least two clamp cups 110 are hinged to the clamp base 120, and each clamp cup 110 is configured with a cup mouth portion 1110. The distal end of the cup mouth portion 1110 is configured with a guide groove 1118, which extends to the outer surface of the clamp cup 110 or is located on the distal inner surface of the clamp cup 110. Since the telescopic member 150 needs to open the clamp cup 110 when moving, the guide groove 1118 is used to guide the movement of the telescopic member 150 relative to the clamp cup 110, making it easier for the telescopic member 150 to apply force.

[0137] Furthermore, the cup portion 1110 is configured as a flat mouth or a serrated mouth or both. According to different lesion areas, a suitable forceps cup 110 can be selected to facilitate the forceps cup 110 to clamp and bite to separate the sample.

[0138] The forceps cup 110 is constructed with a hinge hole 1117 to facilitate hinged connection with the forceps base 120 using a pin 113. Furthermore, each forceps cup 110 has a fixing hole 1116 at its proximal end, connected to a corresponding traction rope 431 to facilitate driving the forceps cup 110 to rotate relative to the forceps base 120 to achieve opening and closing. The forceps cup 110 is recessed with a storage cavity 1114 to define a collection cavity. Furthermore, the forceps base 120 is hollow, so that it cooperates with the forceps cup 110 to form a storage cavity. The forceps cup 110 is also provided with a drainage hole 1115, which is connected to the collection cavity to allow blood remaining in the collection cavity to flow out during sampling.

[0139] As shown in Figures 16, 19 and 3, in an optional embodiment, the telescopic member 150 is a sampling needle, comprising a needle body 1521 and a telescopic member distal end 1502 located at the distal end of the needle body 1521, wherein the telescopic member distal end 1502 is a pointed cone head, wherein the needle body 1521 is cylindrical or prismatic, and the outer wall of the needle body 1521 is provided with a plurality of barb structures 151, each barb structure 151 being arranged at intervals along a first direction, and each barb structure 151 being inclined from the distal end toward the proximal end. The telescopic member distal end 1502 serves as a collection portion for piercing the lesion area, and the storage portion is provided on the needle body 1521 and is provided with a plurality of barb structures 151. Specifically, along the axial direction of the needle body 1521, the area between any two adjacent barb structures 151 can be used to store samples. Since the barb structures 151 are arranged obliquely, the sample can move from the distal end to the proximal end, and the movement of the sample from the proximal end to the distal end is limited.

[0140] Furthermore, the proximal end of the telescopic member 150 is connected to the distal end of the telescopic drive member 211 via a connecting tube 1551. This allows the telescopic member 150 to be connected and moved simultaneously with the telescopic drive member 211, facilitating removal of the telescopic member 150 relative to the telescopic drive member 211. Furthermore, the connecting tube 1551 can abut against the guide member 160 to limit movement of the telescopic member 150 toward the distal end. In some embodiments, a small-diameter breakaway portion 156 is configured at the proximal end of the telescopic member 150. Once sampling is complete, the small-diameter breakaway portion 156 can be broken to allow the telescopic member 150 to be removed from the telescopic drive member 211.

[0141] Furthermore, a first stopper 154 is configured on one side of the telescopic member 150 located near the storage portion. The first stopper 154 can abut against the distal end surface of the guide member 160 to position, assemble, and limit the movement of the telescopic member 150, ensuring that the telescopic member 150 has sufficient space to serve as a storage portion. When the first stopper 154 abuts against the guide member 160, it can be used to release the telescopic member 150 relative to the driving member 430. The first stopper 154 can be a stopper boss protruding radially outward from the telescopic member 150.

[0142] As shown in Figure 16, in some embodiments, the first stopper 154 is located on the distal side of the guide member 160, and the connecting tube 1551 is located on the proximal side of the guide member 160. In this case, the first stopper 154 can abut the guide member 160 to limit the proximal movement of the telescopic member 150, and the connecting tube 1551 can abut the guide member 160 to limit the distal movement of the telescopic member 150. Simultaneously, when the telescopic member 150 needs to be released, the second control member 4202 can be driven to move proximally, causing the first stopper 154 to abut against the guide member 160 and be restrained. As the force applied to the second control member 4202 gradually increases, the guide member 160's restraining action on the first stopper 154 causes the telescopic member 150 to disengage from the telescopic drive member 211, thereby releasing the telescopic member 150. In this case, the aforementioned release space 4103 is the area that allows the second control member 4202 to move proximally.

[0143] During release, the small-diameter disconnecting portion 156 weakens the strength of the telescopic member 150 at this location. Under a relatively large pulling force, the telescopic member 150 can be disconnected from the small-diameter disconnecting portion 156 relative to the telescopic driving member 211, thereby being released. Alternatively, as the force driving the second control member 4202 increases, the telescopic member 150 and the telescopic driving member 211 can be disconnected at the connecting tube 1551, thereby being released.

[0144] As shown in Figures 1 to 19, an embodiment of the present application further provides a sampling method, which performs a sampling operation based on the above-mentioned sampling device 2000. The sampling method includes the following steps:

[0145] S10: In the initial state, the distal end of the telescopic member 150 is located at and close to the distal end of the forceps cup 110. When the sampling device 2000 is located at the tissue to be sampled, the first control member 4201 is driven to move toward the distal end, driving the forceps cup 110 to open, so that the collection portion at the distal end of the telescopic member 150 enters the tissue 300.

[0146] S20: Under the movement trend of resetting, the first control member 4201 moves toward the proximal side, driving the forceps cup 110 to close to remove the tissue 300;

[0147] S30: driving the second control member 4202 to move toward the distal end, so that the distal end of the telescopic member 150 opens the forceps cup 110 and the tissue 300 removed in S2 is always stopped in the forceps cup 110, thereby moving the tissue 300 toward the proximal end of the telescopic member 150 to the storage portion 153, leaving the collection portion 152 empty;

[0148] S40: Under the resetting movement trend, the second control member 4202 moves toward the proximal side, causing the telescopic member 150 to return to its initial state. Simultaneously, the tissue 300 follows the telescopic member 150 and moves toward the proximal side, causing the tissue 300 to leave the collection chamber 130 and enter the storage chamber 140. At this point, one tissue sampling is completed.

[0149] S50: repeat S1 to S4 to complete N times of tissue sampling;

[0150] S60: driving the second control member 4202 to move toward the proximal side so that the first limit member 154 on the telescopic member 150 abuts against the guide member 160 until the telescopic member 150 is released. The user sequentially removes and collects the N tissue samples on the released telescopic member 150.

[0151] It should be noted in advance that the elastic member 450 drives the control member 420 to move toward the proximal side for resetting, and the control member 420 can be moved toward the distal side by manual pushing by the doctor.

[0152] In the initial state, the first elastic member 451 and the second elastic member 452 corresponding to the first control member 4201 and the second control member 4202 are both in a natural state. In this state, the user causes the sheath 210 to extend into the lesion area, and the telescopic member 150 is located within the forceps cup 110 to prevent puncturing other areas during the extension process. When the forceps body structure extends into the specific area to be sampled under the action of the sheath 210, the first control member 4201 can be pushed to move toward the distal side. The first control member 4201 drives the two forceps cups 110 to rotate relative to the forceps base 120 through the opening and closing drive member 212, thereby opening and exposing the telescopic member 150 located within the forceps cup 110. The collection portion at the distal end of the telescopic member 150 can then penetrate the tissue 300 under the action of an external force. After the penetration reaches a certain extent, the driving force acting on the first control member 4201 is cancelled, and the first control member 4201 moves toward the proximal side under the resetting action of the first elastic member 451. The opening and closing driving member 212 drives the two forceps cups 110 to rotate and close again, and the cup mouth parts 1110 of the two forceps cups 110 cooperate with each other to separate the tissue so that the tissue remains on the telescopic member 150.

[0153] Then, the second control member 4202 is pushed toward the distal end, causing the distal end of the telescopic member 150 to extend through the guide groove 1118 and open the two closed forceps cups 110. However, at this time, the first control member 4201 is only subjected to the force of the first elastic member 451, so the two forceps cups 110 still have a force to clamp toward the telescopic member 150. In this way, as the telescopic member 150 moves toward the distal end, the tissue on the telescopic member 150 is stopped by the forceps cups 110 in the collection chamber 130 and moved to the storage portion 153 of the telescopic member 150, thereby freeing the collection portion 152 for the next operation. Next, the driving force acting on the second control member 4202 is removed, and the second control member 4202 moves toward the proximal end under the action of the second elastic member 452, so that the telescopic member 150 returns to its initial state. At the same time, the tissue 300 in the storage portion 153 moves toward the proximal end synchronously with the telescopic member 150 to enter the storage chamber 140.

[0154] Repeating the above steps multiple times can satisfy multiple tissue sampling.

[0155] After multiple tissue samplings are completed, the second control member 4202 is pulled toward the proximal end. The second control member 4202 drives the telescopic member 150 toward the proximal end via the telescopic drive member 211, and the pulling force is slowly increased during the pulling process until the first stop member 154 on the telescopic member 150 abuts the guide member 160 in the clamp base 120. The pulling force is further increased until the telescopic member 150 releases from the telescopic drive member 211. The user can then remove the telescopic member 150 to remove and collect N tissue samples at once.

[0156] This type of operation does not require multiple entries and exits of the human body. Instead, continuous sampling of multiple samples can be performed with just one entry, which improves operational efficiency, shortens surgical time, and reduces pain and discomfort for patients.

[0157] The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above-mentioned embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0158] The above-described embodiments merely represent several implementation methods of the present application. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent application. It should be noted that a person of ordinary skill in the art may make various modifications and improvements without departing from the spirit of the present application, and these modifications and improvements fall within the scope of protection of the present application. Therefore, the scope of protection of the present patent application shall be determined by the appended claims.

Claims

1. A multi-sampling biopsy device, characterized in that: include: A clamp body mechanism, comprising a clamp cup and a clamp seat that are movably connected, wherein a collection cavity and a storage cavity that are adjacent and connected to each other are formed inside the clamp body mechanism, and the collection cavity is located at the far side of the storage cavity; A telescopic member is disposed in the clamp body mechanism, the telescopic member is provided with a collecting portion and a storage portion, the collecting portion is located at the far side of the storage portion, and the telescopic member can be driven to move back and forth in the collecting cavity and the storage cavity, so that the collecting portion collects tissue and the storage portion stores tissue; as well as A guide member, disposed on the periphery of the telescopic member, for guiding the telescopic member to move back and forth relative to the clamp body mechanism in the distal and proximal directions; When the telescopic member is displaced toward the distal end, the distal end of the telescopic member can protrude beyond the distal end of the forceps cup to open the forceps cup, and stop the tissue at the collection portion in the forceps cup, so that the tissue stopped in the forceps cup is displaced toward the proximal side of the telescopic member to the storage portion.

2. The multi-sampling biopsy device according to claim 1, wherein: The inside of the forceps cup at least includes the collection cavity, and the storage cavity is formed between the proximal end of the collection cavity and the proximal end of the forceps seat or between the proximal end of the collection cavity and the vicinity of the proximal end of the forceps seat.

3. The multi-sampling biopsy device according to claim 2, wherein: The position of the collecting cavity corresponds to the collecting portion of the telescopic member, and the position of the storage cavity corresponds to the storage portion of the telescopic member.

4. The multi-sampling biopsy device according to claim 1, wherein: The guide member is arranged in the clamp body mechanism; or The guide is disposed at or near the proximal end within the clamp seat.

5. The multi-sampling biopsy device according to any one of claims 1 to 4, wherein: The inside of the forceps cup at least includes the collection cavity, and the storage cavity is formed between the proximal end of the collection cavity and the distal end of the guide member.

6. The multi-sampling biopsy device according to claim 1, wherein: The telescopic member is slidably disposed through the guide member; Wherein, the telescopic member is provided with a first limiting member located at the far side of the guiding member, and / or a second limiting member located at the near side of the guiding member.

7. The multi-sampling biopsy device according to claim 1, wherein: The guide member is arranged on the periphery of the telescopic member, and the guide member is slidably connected to the clamp body mechanism; Wherein, the clamp body mechanism is connected with a first limiting member located at the far side of the guide member, or / and a second limiting member located at the near side of the guide member.

8. The multi-sampling biopsy device according to claim 1, wherein: In an initial state, the distal end of the telescopic member is placed in the forceps cup and close to the distal end of the forceps cup, and the distal end of the telescopic member can enter the tissue after the forceps cup is opened.

9. The multi-sampling biopsy device according to claim 1, wherein: The clamp seat comprises a tube seat, the tube seat extends toward the distal end to form two connecting posts, the clamp cup comprises a connected cup body and a connecting piece, the two cup bodies are respectively movably connected to the two connecting posts through a connecting piece, wherein the connected cup bodies, the connecting piece and the connecting posts are located on the same side; Wherein, along the proximal and distal directions, the length of the tube seat is greater than the length of the connecting column.

10. The multi-sampling biopsy device according to claim 1, 2 or 9, wherein: The clamp cup comprises a cup body, and an opening is arranged at the proximal end of the cup body, so that the collection cavity and the storage cavity are connected without any stop.

11. The multi-sampling biopsy device according to claim 10, wherein: The cup mouth portion of the cup body includes an end cutting edge located at the distal end of the cup body, side cutting edges located on both sides extending from the end cutting edge toward the proximal end of the cup body, and the open mouth located at the proximal end of the cup body, wherein the end cutting edge and the side cutting edges are arranged continuously.

12. The multi-sampling biopsy device according to claim 1, wherein: The multi-sampling biopsy device also includes a sheath mechanism, the distal end of which is connected to the proximal end of the clamp body mechanism. The sheath mechanism includes a sheath tube, and the inside of the sheath tube is provided with a telescopic driving member connected to the proximal end of the telescopic member, and an opening and closing driving member connected to the proximal end of the clamp cup and capable of opening and closing the clamp cup.

13. The multi-sampling biopsy device according to claim 12, wherein: The telescopic member is detachably connected to the telescopic driving member.

14. The multi-sampling biopsy device according to claim 12 or 13, wherein: The telescopic member and the telescopic driving member are detachably connected via a releasing member.

15. The multi-sampling biopsy device according to claim 14, wherein: The release member is provided at least on the portion of the telescopic member located on the proximal end side of the guide member, and the release member is used to limit the displacement stroke of the telescopic member toward the distal end side.

16. The multi-sampling biopsy device according to claim 12 or 13, wherein: A first limiting member is provided at least on the portion of the telescopic member located on the distal end side of the guiding member.

17. The multi-sampling biopsy device according to claim 16, wherein: The telescopic member and the telescopic driving member are detachably connected via a connecting pipe; The telescopic member and the connecting tube are interference fit and can be counteracted by the first limiting member and the guiding member until the connecting tube releases the telescopic member, or / and, the connecting tube and the telescopic driving member are interference fit and can be counteracted by the first limiting member and the guiding member until the telescopic member is released by the release of the connecting tube and the telescopic driving member.

18. The multi-sampling biopsy device according to claim 12, characterized in that: The guide is arranged on the clamp body mechanism, and the proximal end of the guide is in contact with the distal end of the sheath tube.

19. The multi-sampling biopsy device according to claim 1, wherein: The clamp cup comprises at least two cup bodies, each of which is configured with a cup mouth portion; The distal end of the cup mouth is configured with a guide groove, which passes through the outer surface of the cup body or is located on the distal inner surface of the cup body; or / and, the cup mouth is configured as a flat mouth type or a serrated type or a combination of the two. 20 . The multi-sampling biopsy device according to claim 1 , wherein the telescopic member is a needle-shaped body, and the distal end of the telescopic member is in the shape of a needle tip.

21. The multi-sampling biopsy device according to claim 1, wherein the outer periphery of the telescopic member is provided with anti-slip protrusions and / or anti-slip depressions.

22. The multi-sampling biopsy device according to claim 1 or 20, wherein the telescopic member comprises a needle body located at the proximal side of the distal end of the telescopic member; in, The needle body is cylindrical or prismatic, and a plurality of barbs are protruding from the outer wall of the needle body. The barbs are arranged at intervals along the distal and proximal directions, and the barbs are inclined from the distal end side toward the proximal end side.

23. The multi-sampling biopsy device of claim 1, wherein: A small-diameter disconnecting portion is configured at the proximal end of the telescopic member.

24. A multi-sampling method, characterized in that Using the multi-sampling biopsy device according to any one of claims 1 to 23, the steps of the multi-sampling method include: S1: In an initial state, the distal end of the telescopic member is located in the forceps cup and close to the distal end of the forceps cup, and when the multi-sampling biopsy device is located at the tissue to be collected, the forceps cup is driven to open, so that the collection part at the distal end of the telescopic member enters the tissue to be collected; S2: driving the forceps cup to close so that the forceps cup removes the tissue; S3: driving the telescopic member to move toward the distal end, so that the distal end of the telescopic member opens the forceps cup and the tissue removed in S2 is stopped in the forceps cup, and then the tissue stopped in the forceps cup is moved toward the proximal side of the telescopic member to the storage part, emptying the collection part; S4: driving the telescopic member to move in the proximal direction so that the telescopic member returns to the initial state, and at the same time, the tissue at the storage portion moves along the proximal direction following the telescopic member, so that the tissue at the storage portion leaves the collection cavity and enters the storage cavity; at this time, one tissue sampling is completed; and S5: Repeat S1 to S4 to complete N times of tissue sampling.

25. The multi-sampling method according to claim 24, wherein: After completing S5, execute S6: drive the telescopic member to move along the proximal direction, so that the first limit member of the telescopic member portion located at the distal end side of the guide member is reversely abutted against the guide member until the telescopic member is released, and the N sample tissues on the released telescopic member are sequentially taken out and collected.

26. A sampling device, characterized in that include: Operating mechanism; and According to any one of claims 1 to 23, the clamp body mechanism and the telescopic member are respectively driven by the operating mechanism.

27. The sampling device according to claim 26, wherein The sampling device also includes a plurality of driving members, and the operating mechanism can drive the forceps cup to open and close by driving the opening and closing driving members among the plurality of driving members to move synchronously, and the operating mechanism can drive the telescopic member to reciprocate by driving the telescopic driving members among the plurality of driving members to move synchronously.

28. The sampling device according to claim 27, wherein The operating mechanism includes a handle body and a plurality of control members, wherein the plurality of control members include a first control member and a second control member; The control member is movably connected to the handle body; the control member can reciprocate relative to the handle body along the distal and proximal directions, and the control member has a movement tendency to return to the distal side or the proximal side; The forceps cup is connected to the first control member via the opening and closing driving member, and the forceps cup is configured to open and close in response to the movement of the first control member; The telescopic member is connected to the second control member through the telescopic driving member, and the telescopic member is configured to move in response to movement of the second control member.

29. An operating mechanism, characterized in that: The operating mechanism includes a handle body and a plurality of control members; A plurality of control members are movably connected to the handle body, each of the control members is connected to a driving member, and the driving member is used to connect to the distal component; Among them, each of the control components can reciprocate relative to the handle body in the distal and proximal directions, and each of the control components has a movement tendency to reset toward the distal side or toward the proximal side. Each of the control components can drive the corresponding driving component to move synchronously and thus drive the distal component to move.

30. The operating mechanism according to claim 29, wherein: The plurality of control members are arranged at intervals along the proximal-distal end direction.

31. An operating mechanism according to claim 29 or 30, wherein: At least the control member located near the distal end is configured with a first through hole for guiding the driving member corresponding to the control member located near the proximal end to penetrate therethrough.

32. The operating mechanism according to claim 29, wherein: The proximal end and / or the distal end of each of the control members is connected with an elastic member, and the elastic member is used to drive the corresponding control member to reset toward the proximal end side or the distal end side.

33. The operating mechanism according to claim 29, wherein: At least one limiting seat is disposed on the handle body, each control member corresponds to at least one limiting seat, and each limiting seat and each control member are arranged at intervals along the distal and proximal directions of the handle body.

34. An operating mechanism according to claim 33, wherein: The limiting seat is provided with a second through hole, and the second through hole is used to guide the driving member corresponding to the control member located near the proximal end to pass through.

35. The operating mechanism according to claim 33, wherein: Each of the limit seats is located at the distal end of the corresponding control member, and an elastic member is connected between each of the limit seats and the corresponding control member, and the elastic member is used to drive the corresponding control member to move toward the proximal side.

36. An operating mechanism according to claim 29, 32, 33 or 35, wherein: The handle body is configured with a release space on a side of at least one of the control members facing the proximal end.

37. The operating mechanism according to claim 31, wherein: Each of the control members is configured with a connecting hole, and the proximal end portion of each of the driving members is directly or indirectly connected to the hole wall of the connecting hole.

38. The operating mechanism of claim 29, wherein: The handle body comprises a gripping rod body, the gripping rod body is configured with an assembly cavity and a guide slot connected to the assembly cavity, and the guide slot passes through the outer peripheral surface of the handle body; The driving member is installed in the assembly cavity, and a portion of each of the control members extends through the guide slot into the assembly cavity to be connected with the corresponding driving member, and each of the control members is movably connected to the holding rod body; The handle body comprises a connecting sleeve connected to the distal end of the gripping rod body; the connecting sleeve is configured with a connecting cavity communicated with the assembling cavity.

39. An operating mechanism according to claim 29 or 38, wherein: The handle body comprises a gripping rod body and a connecting sleeve, a clamping portion is provided at the distal end of the gripping rod body, a fixing tube is clamped in the clamping portion, the driving member is passed through the fixing tube, and the connecting sleeve is sleeved on the outer periphery of the clamping portion.

40. The operating mechanism of claim 39, wherein: The fixing tube and / or the connecting sleeve are configured as a limiting seat that can abut against the control member, and an elastic member is connected between the limiting seat and the corresponding control member.

41. The operating mechanism according to claim 29, wherein: The distal end of the operating mechanism is connected to a sheath tube, and each of the driving members is inserted into the sheath tube; Each of the driving members includes at least one traction rope; When part of the driving members includes multiple traction ropes, the proximal ends of the multiple traction ropes are respectively connected to one of the control members, or a main rope is connected to the proximal ends of the multiple traction ropes through a coupling member, and the proximal end of the main rope is connected to one of the control members.

42. An operating mechanism according to claim 41, wherein: The sheath tube comprises a spring tube, and the proximal end of the spring tube is connected to the handle body through a supporting tube.

43. An operating mechanism according to claim 41 or 42, wherein: The sheath tube comprises a spring tube and a lubrication tube which are sequentially sleeved from the outside to the inside, and each of the driving members is inserted into the lubrication tube.

44. A sampling device, characterized in that include: Distal components; An operating mechanism according to any one of claims 29 to 43, wherein the operating mechanism is used to control the distal component; and A driving member connects the operating mechanism and the distal component.

45. The sampling device of claim 44, wherein: The distal component comprises: A clamp body mechanism, comprising a clamp seat and a clamp cup movably connected to the clamp seat, wherein the clamp body mechanism is configured with a collection chamber and a storage chamber that are adjacent and connected to each other, and the collection chamber is located at the far side of the storage chamber; a telescopic member, disposed in the clamp body mechanism, the telescopic member being provided with a collecting portion and a storage portion, the collecting portion being located at the far side of the storage portion, the telescopic member being capable of reciprocating in the collecting cavity and the storage cavity, so that the collecting portion collects tissue and the storage portion stores tissue; and A guide member, disposed on the periphery of the telescopic member, for guiding the telescopic member to reciprocate relative to the clamp body mechanism along the distal and proximal directions; Among them, the forceps cup is connected to the corresponding first control member among the multiple control members through an opening and closing driving member, and the telescopic member is connected to the corresponding second control member among the multiple control members through a telescopic driving member; the telescopic member is configured to move in response to the movement of the second control member, and the forceps cup is configured to open and close in response to the movement of the first control member; the telescopic member can move toward the distal side to open the forceps cup, and the sample tissue at the telescopic member can be moved to the storage part of the telescopic member under the stopping action of the forceps cup.

46. ​​The sampling device of claim 45, wherein: The clamp body mechanism comprises at least two clamp cups, each of which is configured with a cup opening; The distal end of the cup mouth is configured with a guide groove, which passes through the outer surface of the cup body or is located on the inner surface of the distal end of the clamp cup; or / and, the cup mouth is configured as a flat mouth type or a serrated type or a combination of the two.

47. The sampling device of claim 45, wherein: The telescopic member is a sampling needle, and the sampling needle comprises a needle body and a pointed cone head located at the distal side of the needle body; The needle body is cylindrical or prismatic, and a plurality of barbs are protruding from the outer wall of the needle body. The barbs are arranged at intervals along the distal and proximal directions, and the barbs are inclined from the distal side toward the proximal side.

48. The sampling device of claim 45, wherein: The proximal end of the telescopic member is connected to the distal end of the driving member via a release member, or / and a small-diameter disconnecting portion is configured at the proximal end of the telescopic member.

49. A sampling device according to claim 45 or 48, wherein The telescopic member is configured with a limiting member, and the limiting member can abut against the guide member to limit the movement of the telescopic member toward the proximal end side.

50. A sampling method, characterized in that Based on the sampling device according to any one of claims 45 to 49, the sampling method comprises the following steps: S10: In the initial state, the distal end of the telescopic member is located in the forceps cup and close to the distal end of the forceps cup. When the sampling device is located at the tissue to be sampled, the first control member is driven to move toward the distal end, the forceps cup is driven to open, and the collection portion at the distal end of the telescopic member enters the tissue to be sampled; S20: Under the movement trend of resetting, the first control member moves toward the proximal side to drive the forceps cup to close so that the forceps cup removes the tissue; S30: driving the second control member to move toward the distal end, so that the distal end of the telescopic member opens the forceps cup and the tissue removed in S20 is always stopped in the forceps cup, and then the tissue stopped in the forceps cup moves toward the proximal side of the telescopic member to the storage part, emptying the collection part; S40: Under the movement trend of resetting, the second control member moves toward the proximal side, so that the telescopic member returns to the initial state, and at the same time, the tissue at the storage portion follows the telescopic member to move toward the proximal side, so that the tissue at the storage portion leaves the collection cavity and enters the storage cavity; at this time, one tissue sampling is completed; and S50: Repeat S10 to S40 to complete N times of tissue sampling.

51. The sampling method according to claim 50, wherein: After completing S50, the sampling method further includes: S60: driving the second control member to move toward the proximal end side so that the limiting portion of the telescopic member abuts against the guiding member until the telescopic member is released, and sequentially taking out and collecting the N sample tissues on the released telescopic member.

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