Tools for interrogating dynamic organizational principles of protein complexes in vivo

The DNA-caliper and Ab-oligo system addresses the limitations of current methods by enabling simultaneous detection of multiple protein-protein and protein-DNA interactions, providing comprehensive and quantitative data on protein abundance and interactions.

WO2025019385A1PCT designated stage expired Publication Date: 2025-01-23RGT UNIV OF CALIFORNIA +4
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Patent Information

Application Number
PCT/US2024/037959
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-03-05
Filing Date
2024-07-14
Publication Date
2025-01-23

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Abstract

Provided herein are methods and tools that enable(s) simultaneous identification and characterization of multiple interactions between proteins and between proteins and DNA or RNA within functional complexes. This transformative approach / method allows for high-throughput queries of the dynamic interactions of proteins and expands the focus from single interactions towards an unprecedented, multidimensional interrogation of the cellular complexity.
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Citation Information

Patent Citations

  • Identification of biomolecular interactions

    US10655162B1

  • Proximity assay with detection based on hybridisation chain reaction (HCR)

    WO2015118029A1