Microneedle patch and adhesive composition

Abstract

The present invention relates to a microneedle patch and an adhesive composition and, more specifically, to a microneedle patch and an adhesive composition, in which when the microneedle patch is provided, microneedles can be directly attached to an adhesive sheet, without a support film for supporting the hydrophilic microneedles.

Description

Microneedle patches and adhesive compositions

[0001] The present invention relates to a microneedle patch and an adhesive composition, and more particularly, to a microneedle patch and an adhesive composition in which the microneedles can be directly attached to an adhesive sheet without a support film supporting the hydrophilic microneedles when providing the microneedle patch.

[0002] Although numerous drugs and bioactive substances have been developed for the treatment of diseases, there are still issues that need to be improved in delivering drugs and bioactive substances into the body, such as the passage of biological barriers (e.g., skin, oral mucosa, and blood-brain barrier) and the efficiency of drug delivery.

[0003] Drugs and bioactive substances are typically administered orally in tablet or capsule form. However, many drugs cannot be effectively delivered using this method alone due to factors such as digestion or absorption in the gastrointestinal tract or clearance through hepatic mechanisms. Furthermore, some drugs cannot effectively diffuse across the intestinal mucosa. Patient compliance is also a concern (e.g., medications must be taken at specific intervals, or in the case of critically ill patients who cannot take medication).

[0004] Another common technique for delivering drugs and bioactive substances is the use of conventional needles. While this method is more effective than oral administration, it carries the risk of pain at the injection site, local skin damage, bleeding, and infection at the injection site.

[0005] To address the aforementioned issues, various microneedle patches containing microneedles have been developed. To date, microneedle patches have primarily been used for in vivo drug delivery, blood collection, and detection of in vivo analytes. Metals and various polymers have been used as microneedle materials. Recently, biodegradable polymers have been attracting attention as microneedle materials.

[0006] FIG. 1 is a drawing and a photograph illustrating a microneedle patch (1000) including a microneedle (14) according to the prior art. FIG. 1 (A) is a side cross-sectional view of the microneedle patch (1000) according to the prior art, FIG. 1 (B) is a state in which a protective release film (11) is removed from the microneedle patch (1000), FIG. 1 (C) is a photograph showing an adhesive sheet (6) and a support sheet (12) provided on an upper surface of the adhesive sheet (6) from the side, and FIG. 1 (D) corresponds to a planar photograph of the adhesive sheet (6) and the support sheet (12) viewed from above.

[0007] Referring to Fig. 1, the microneedle patch (1000) includes an adhesive sheet (6), a support film (12) provided on the upper surface of the adhesive sheet (6), and microneedles (14) provided on the upper surface of the support film (12). Furthermore, the microneedle patch (1000) may further include a protective release film (11) arranged on the upper surface of the adhesive sheet (6) to surround the support film (12).

[0008] The above adhesive sheet (6) provides adhesive force so that the microneedles (14) adhere to the user's skin. The adhesive sheet (6) is covered by the aforementioned protective release film (11) before using the microneedle patch (1000), and when in use, the user removes the protective release film (11) (state of (B) in FIG. 1) and exposes the adhesive sheet (6).

[0009] The above-mentioned support film (12) is provided on the upper surface of the adhesive sheet (6) and serves as a support on which the microneedles (14) are formed. The microneedles (14) may be made of a hydrophilic or water-soluble material. In addition, the adhesive sheet (6) may be made of a hydrophobic material to maintain adhesive strength.

[0010] In this case, since the hydrophilic microneedles (14) do not attach with sufficient bonding strength to the hydrophobic adhesive sheet (6), conventionally, a hydrophilic support film (12) is first formed or attached to the upper surface of the adhesive sheet (6), and then the microneedles (14) are formed on the upper surface of the support film (12). (C) and (D) of Fig. 1 illustrate a state in which the support film (12) is provided on the upper surface of the adhesive sheet (6).

[0011] When a hydrophilic support film (12) is provided in this manner, microneedles (14) can be formed on the aforementioned support film (12), as shown in FIG. 2.

[0012] In the case of the prior art microneedle patch (1000) of the aforementioned structure, as described above, when in use, the protective release film (11) is removed to expose the adhesive sheet (6). However, since the support film (12) for forming the microneedles (14) is provided on the upper surface of the adhesive sheet (6), the adhesive sheet (6) that is actually exposed corresponds to the edge area (A) of the upper surface of the adhesive sheet (6), as illustrated in (B) of FIG. 1.

[0013] That is, when a microneedle patch (1000) according to the prior art is attached to the human skin, only the edge area (A) of the upper surface of the adhesive sheet (6) is attached to the human body, and the area of ​​the support film (12) where the microneedles (14) are formed is not exposed to the adhesive sheet (6), so no adhesive force is directly applied. As a result, in the structure according to the prior art, there was a problem in that the adhesive force for attaching the microneedles (14) to the skin was insufficient, and the microneedles (14) did not adhere closely to the skin, resulting in a very low drug delivery capability.

[0014] In order to solve the above-mentioned problems, the present invention aims to provide a microneedle patch that can adhere microneedles to the skin when the microneedle patch is attached to the user's skin.

[0015] In addition, the present invention aims to provide an adhesive composition to which hydrophilic microneedles can be directly connected.

[0016] The above object of the present invention is achieved by a microneedle patch comprising an adhesive sheet, hydrophilic microneedles provided on the adhesive sheet, and characterized in that the microneedles are directly connected to one surface of the adhesive sheet.

[0017] Here, the hydrophilic microneedles are composed of a plurality of pieces, and the adhesive sheet can be exposed between the plurality of microneedles.

[0018] Furthermore, the adhesive sheet may include a hydrophilic polymer.

[0019] Meanwhile, the adhesive sheet is formed of an adhesive composition containing the hydrophilic polymer and an adhesive, and includes an adhesive layer to which the microneedles are connected, and a film layer provided under the adhesive layer, and the hydrophilic polymer may be included in the adhesive composition in an amount of 5 to 40 wt%.

[0020] In addition, the hydrophilic polymer may be composed of one or a mixture of two or more selected from CMC (carboxymethyl cellulose), Carbomer, HPMC (hydroxypropyl methyl cellulose), PVP (polyvinyl pyrrolidone), PVA (polyvinyl alcohol), and Guar Gum.

[0021] Meanwhile, the adhesive may contain 10 to 50 wt% of synthetic rubber, 30 to 70 wt% of hydrogenated hydrocarbon resin, 5 to 20 wt% of mineral oil, and 0.2 to 3 wt% of antioxidant.

[0022] Furthermore, the contact angle of the adhesive sheet may be 70° to 100°.

[0023] Additionally, the viscosity of the hydrophilic polymer may be 5 mPa·s to 5,000 mPa·s.

[0024] Meanwhile, the above-described object of the present invention can be achieved by an adhesive composition that forms an adhesive layer of an adhesive sheet included in a microneedle patch, wherein the composition is characterized in that it includes a hydrophilic polymer.

[0025] Furthermore, the hydrophilic polymer may be composed of one or a mixture of two or more selected from CMC (carboxymethyl cellulose), Carbomer, HPMC (hydroxypropyl methyl cellulose), PVP (polyvinyl pyrrolidone), PVA (polyvinyl alcohol), and GuarGum.

[0026] Additionally, the hydrophilic polymer may be included in the composition in an amount of 5 to 40 wt%.

[0027] Meanwhile, the composition includes an adhesive and the hydrophilic polymer, and the adhesive may include 10 to 50 wt% of synthetic rubber, 30 to 70 wt% of hydrogenated hydrocarbon resin, 5 to 20 wt% of mineral oil, and 0.2 to 3 wt% of antioxidant.

[0028] In this case, the viscosity of the hydrophilic polymer may be 5 mPa·s to 5,000 mPa·s.

[0029] According to the present invention having the above-described configuration, when attaching a microneedle patch to a user's skin, the adhesive sheet between the microneedles is exposed, thereby effectively adhering the microneedles to the skin.

[0030] In addition, according to the present invention, by manufacturing an adhesive sheet using an adhesive composition including a hydrophilic polymer, microneedles can be directly connected to one surface of the adhesive sheet.

[0031] Figure 1 is a drawing showing a microneedle patch according to the prior art;

[0032] Figure 2 is a photograph of the microneedles in Figure 1.

[0033] FIG. 3 is a drawing illustrating a microneedle patch according to one embodiment of the present invention;

[0034] Figure 4 is a photograph of the microneedles in Figure 3.

[0035] FIG. 5 is a drawing illustrating a method for manufacturing a microneedle patch using a blowing tension method according to one embodiment of the present invention.

[0036] FIG. 6 is a schematic drawing illustrating a method for manufacturing a microneedle patch having a configuration according to FIG. 3 by a mold method.

[0037] Figure 7 is a cross-sectional view showing the configuration of the adhesive layer.

[0038] Figure 8 is a photograph of microneedles formed on an adhesive sheet containing various hydrophilic polymers.

[0039] Figure 9 is a photograph taken in a state where microneedles are not formed accurately.

[0040] Figure 10 is a photograph showing whether microneedles are formed according to the change in contact angle depending on the content of hydrophilic polymer in the adhesive sheet according to the present invention and the adhesive sheet according to the prior art when a microneedle patch is manufactured by the blowing tension method.

[0041] Figure 11 is a photograph showing the degree of microneedle formation according to the viscosity of a hydrophilic polymer when a microneedle patch is produced by a blowing tension method.

[0042] Hereinafter, a microneedle patch according to an embodiment of the present invention will be described in detail with reference to the drawings.

[0043] FIG. 3 is a drawing illustrating a microneedle patch (2000) according to one embodiment of the present invention, and FIG. 4 corresponds to a photograph actually taken of the microneedle (14) in FIG. 3. (A) of FIG. 3 is a side cross-sectional view of the microneedle patch (2000) according to the present invention, (B) of FIG. 3 is a side cross-sectional view illustrating a state in which a protective release film (11) is removed from the microneedle patch (2000), (C) of FIG. 3 is a photograph showing an adhesive sheet (10) from the side, and (D) of FIG. 3 corresponds to a planar photograph of the adhesive sheet (10) viewed from above.

[0044] Referring to FIGS. 3 and 4, the microneedle patch (2000) may include an adhesive sheet (10) and microneedles (14) provided on the adhesive sheet (10).

[0045] Here, the microneedle (14) is inserted into the skin and dissolved, and may be made of a material having biocompatibility and biodegradability and a water-soluble or hydrophilic material.

[0046] For example, the microneedles (14) may be selected from the group consisting of hyaluronic acid and its salts, polyvinylpyrrolidone, polyvinyl alcohol, cellulose polymer, dextran, gelatin, glycerin, polyethylene glycol, polysorbate, propylene glycol, povidone, carbomer, gum ghatti, guar gum, glucomannan, glucosamine, dammer resin, rennet casein, locust bean gum, microfibrillated cellulose, psyllium seed gum, xanthan gum, arabino galactan, gum arabic, alginic acid, gelatin, gellan gum, carrageenan, karaya gum, curdlan, chitosan, chitin, It may be composed of tara gum, tamarind gum, tragacanth gum, furcelleran, pectin or pullulan, hydroxypropyl methylcellulose, hydroxyalkyl cellulose, ethyl hydroxyethyl cellulose, alkyl cellulose, and carboxymethyl cellulose.

[0047] Meanwhile, in the present invention, the microneedles (14) may be directly connected or formed on the upper surface or one surface of the adhesive sheet (10). That is, the microneedles (14) may be directly formed on or attached to the upper surface of the adhesive sheet (10). Looking at (C) and (D) of FIG. 3, it can be confirmed that there is no hydrophilic support film as in the prior art on the upper surface of the adhesive sheet (10). In addition, as illustrated in FIG. 4, it can be confirmed that the microneedles are normally attached and provided on the upper surface of the adhesive sheet (10) without the hydrophilic support film.

[0048] In this way, when the microneedles (14) are directly provided on the upper surface of the adhesive sheet (10) and the microneedles (14) are composed of multiple pieces, the adhesive sheet (10) between the multiple microneedles (14) may be exposed as shown in (A) and (B) of FIG. 3.

[0049] That is, when a user removes the protective film (11) as shown in (B) of FIG. 3 to use the microneedle patch (2000), not only the edge area of ​​the adhesive sheet (10) but also the adhesive sheet (10) between the microneedles (14) may be exposed.

[0050] Accordingly, when the upper surface of the adhesive sheet (10) provided with the microneedles (14) is attached to the human skin, the adhesive sheet (10) is exposed between the microneedles (14) as well as the edge area of ​​the adhesive sheet (10), so that the microneedles (14) can be more effectively adhered to the human skin. In this case, drugs, etc. can be more effectively delivered to the human body through the microneedles (14), so that the drug delivery capability of the microneedle patch (2000) can be greatly increased.

[0051] Meanwhile, Fig. 5 is a drawing illustrating a method for manufacturing a microneedle patch (2000, 2000') according to the present invention. The method corresponds to the droplet extension (DEN) method developed by the applicant of the present invention. For microneedles manufactured using the droplet extension method, reference may be made to Korean Patent Nos. 1254240, 1285085, 1636069, 1816922, 2103194, and 2127123, the entire contents of which may be incorporated herein by reference.

[0052] Referring to FIG. 5, the step of manufacturing the microneedle patch (2000, 2000') may include the step of first providing a pair of adhesive sheets (10, 10'), and the step of spotting a biodegradable viscous material (13, 13') on at least one of the pair of adhesive sheets (10, 10').

[0053] The adhesive sheet (10, 10') may be provided, for example, on a pair of substrates (not shown). In this case, the adhesive sheet (10, 10') may be provided by being applied and dried on the substrates, or may be provided in a sheet state.

[0054] In the present invention, as previously discussed, the hydrophilic support film can be omitted on the opposing surfaces of the adhesive sheets (10, 10'). As a result, microneedles (14, 14') can be directly formed on the opposing surfaces (upper surfaces) of the adhesive sheets (10, 10').

[0055] Meanwhile, in (A) of FIG. 5, the viscous material (13, 13') is depicted as being spotted on both of the pair of adhesive sheets (10, 10'), but this is not limited thereto. For example, it is also possible to spot the viscous material (13, 13') on only one of the pair of adhesive sheets (10, 10').

[0056] Next, the pair of adhesive sheets (10, 10') are moved relative to each other ((A) of FIG. 5) so that they come closer to each other, so that the viscous material (13, 13') is brought into contact with each other between the pair of adhesive sheets (10, 10'), and the pair of adhesive sheets (10, 10') are spaced apart so that the viscous material (13, 13') is tensioned ((B) of FIG. 3).

[0057] In this way, when the pair of adhesive sheets (10, 10') are spaced apart from each other, if the bonding force between the viscous material (13, 13') forming the microneedles and the pair of adhesive sheets (10, 10') becomes weak, the viscous material (13, 13') may not be tensioned in the tensioning step of Fig. 3 (B) and the viscous material (13, 13') may be separated from the pair of adhesive sheets (10, 10'). In the present invention, by including a hydrophilic polymer in the adhesive sheets (10, 10'), the bonding force between the viscous material (13, 13') forming the microneedles and the pair of adhesive sheets (10, 10') is maintained.

[0058] That is, the adhesive force between the above-mentioned viscous material (13, 13') and the pair of adhesive sheets (10, 10') can be determined to be such that the above-mentioned viscous material (13, 13') can form a tip portion, or more.

[0059] Next, the above-mentioned viscous material (13, 13') is solidified and the pair of adhesive sheets (10, 10') are separated to form microneedles (14, 14') directly on the pair of adhesive sheets (10, 10').

[0060] In this case, the viscous material (13, 13') can be solidified by means of blowing air, etc. After the viscous material (13, 13') is sufficiently solidified, when the pair of adhesive sheets (10, 10') are further separated, the viscous materials (13, 13') that were connected to each other are separated, forming microneedles (14, 14') having tips, and completing the microneedle patch (2000, 2000') (Fig. 3 (C)).

[0061] Meanwhile, as described above, since the microneedle (14) has water solubility or hydrophilicity, if the adhesive sheet (10) has hydrophobicity as in the prior art, the bonding force between the microneedle (14) and the adhesive sheet (10) becomes very low. In this case, when the microneedle patch (2000) is manufactured by the blowing tension method according to the above-described FIG. 5, if the adhesive sheets (10) are spaced apart on both sides, the viscous material (13, 13') between the adhesive sheets (10) may not be tensioned on both sides, and the viscous material (13, 13') may be separated from one of the adhesive sheets (10), so that the microneedle (14) may not be formed.

[0062] These problems can occur not only in the aforementioned method of manufacturing microneedle patches using the blowing tension method, but also in the case of manufacturing using the mold method. Fig. 6 schematically illustrates a method of manufacturing a microneedle patch having the configuration of Fig. 3 using the mold method.

[0063] Referring to Fig. 6, when manufacturing a microneedle patch by a mold method, a needle composition (400) is placed in a cavity (310) of a mold (300), an adhesive sheet (410) is provided on top of the cavity, and the needle composition (400) is dried or dried through an appropriate heat treatment. Then, when the needle composition (400) is dried, the adhesive sheet (410) is pulled to separate it from the mold (300).

[0064] In this way, when the adhesive sheet (410) is separated from the mold (300), if the bonding force between the adhesive sheet (410) and the microneedles (420) becomes weak, some of the microneedles (420A) among the microneedles (420) may not be separated from the mold (300) and only the adhesive sheet (410) may be separated.

[0065] The present invention provides an adhesive sheet and an adhesive composition that maintains the bonding strength between the adhesive sheet (10) and the hydrophilic microneedles (14) to a level that enables the production of a microneedle patch (2000), and further maintains the adhesive strength so that the adhesive sheet (10) can be firmly attached to the skin of a human body. This will be described in detail below.

[0066] Fig. 7 is a side cross-sectional view illustrating an adhesive sheet (10) according to the present invention. In Fig. 7, the microneedles (14) are illustrated with the sheet omitted.

[0067] Referring to Fig. 7, the adhesive sheet (10) may include an adhesive layer (10A) and a film layer (10B) provided on the lower portion of the adhesive layer (10A). The aforementioned microneedles (14) are provided on the upper surface of the adhesive layer (10A).

[0068] The above film layer (10B) may include, for example, at least one of a PET (polyester) film and a PU (poly urethan) film. However, the film layer (10B) is not limited to the types described above and may be implemented in various ways.

[0069] Meanwhile, the adhesive layer (10A) may be formed from an adhesive composition, which may include a hydrophilic polymer and an adhesive. That is, in the present invention, the adhesive layer (10A) of the adhesive sheet (10) is manufactured using an adhesive composition including a hydrophilic polymer.

[0070] Accordingly, the adhesive layer (10A) becomes hydrophilic, and accordingly, the adhesive sheet (10) to which the microneedles (14) are attached becomes hydrophilic. When the adhesive sheet (10) or the adhesive layer (10A) becomes hydrophilic, even when the microneedles (14) are formed on the upper surface of the adhesive layer (10A), the bonding force between the adhesive sheet (10) and the microneedles (14) can be sufficiently maintained.

[0071] According to the inventor's experiments, it is preferable that the hydrophilic polymer be included in the adhesive composition in an amount of 5 to 40 wt%. If the hydrophilic polymer is included in the adhesive composition in an amount of less than 5 wt%, the bonding force between the adhesive layer (10A) and the microneedles (14) is weak, making it difficult to form a microneedle patch (2000). In addition, if the hydrophilic polymer is included in the adhesive composition in an amount exceeding 40 wt%, the adhesive force of the adhesive layer (10A) becomes very weak, making it difficult to attach the microneedle patch (2000) to the human skin.

[0072] For example, the hydrophilic polymer may be composed of one or a mixture of two or more selected from CMC (carboxymethyl cellulose), Carbomer, HPMC (hydroxypropyl methyl cellulose), PVP (polyvinyl pyrrolidone), PVA (polyvinyl alcohol), and Guar Gum.

[0073] Meanwhile, the aforementioned adhesive may contain 10 to 50 wt% of synthetic rubber, 30 to 70 wt% of hydrogenated hydrocarbon resin, 5 to 20 wt% of mineral oil, and 0.2 to 3 wt% of antioxidant.

[0074] Figure 8 is a photograph showing a state in which microneedles are formed on the upper surface of an adhesive sheet (10) including a hydrophilic polymer according to the present invention.

[0075] Referring to FIG. 8, (A) of FIG. 8 includes CMC (carboxymethyl cellulose) as a hydrophilic polymer, (B) of FIG. 8 includes Carbomer as a hydrophilic polymer, (C) of FIG. 8 includes HPMC (hydroxypropyl methyl cellulose) as a hydrophilic polymer, (D) of FIG. 8 includes PVP (polyvinyl pyrrolidone) as a hydrophilic polymer, and (E) of FIG. 8 includes PVA (polyvinyl alcohol) as a hydrophilic polymer.

[0076] The inventor of the present invention included 5 to 40 wt% of each hydrophilic polymer described above in the adhesive composition, and manufactured a microneedle patch by the blowing tension method according to FIG. 5.

[0077] As shown in Fig. 8, when a microneedle patch (2000) is manufactured using an adhesive sheet (10) according to the present invention, it can be seen that the adhesive sheet (10) and the microneedle (14) are not separated and are manufactured normally.

[0078] Meanwhile, Fig. 9 is a photograph taken when a microneedle patch is manufactured by the blowing tension method according to Fig. 5 when the content of the hydrophilic polymer in the adhesive composition is less than the aforementioned 5 wt%. Fig. 9 (A) is a case where no hydrophilic polymer is included, and Fig. 9 (B) is a case where Guar Gum is included in an amount of less than 5 wt% among the hydrophilic polymers.

[0079] As illustrated in FIG. 9, when the hydrophilic polymer included in the adhesive composition is less than the aforementioned 5 wt%, the bonding force between the adhesive layer (10A) of the adhesive sheet (10) and the microneedles (14) becomes weak. Therefore, when the microneedle patch (2000) is manufactured by the blowing tension method according to FIG. 5, it can be seen that, as previously described, the viscous composition (13, 13') (see FIG. 5) is not tensioned and is not separated from one side of the pair of adhesive sheets (10) to form a microneedle (14).

[0080] Meanwhile, the contact angle of the adhesive sheet (10) according to the present invention may be 70° to 100°. Here, the contact angle may be defined as the angle formed by the liquid-gas interface and the liquid-solid interface when a liquid droplet, such as a water droplet, exists on a solid.

[0081] FIG. 10 is a photograph showing whether microneedles (14) are formed according to the change in contact angle depending on the content of hydrophilic polymer in the adhesive sheet (10) according to the present invention and the adhesive sheet according to the prior art when a microneedle patch is manufactured by the blowing tension method according to FIG. 5.

[0082] Figures (A), (B), (C), and (D) of Figures 10 show the state in which the contact angle is measured, and Figures (E), (F), (G), and (H) of Figures 10 show whether microneedles are formed when a microneedle patch is manufactured by the method according to Figure 5 according to the corresponding contact angle. For example, Figure 10 (E) corresponds to Figure 10 (A), Figure 10 (F) corresponds to Figure 10 (B), Figure 10 (G) corresponds to Figure 10 (C), and Figure 10 (H) corresponds to Figure 10 (D).

[0083] Figure 10 (A) shows that the content of the hydrophilic polymer is less than 5 wt%, and the measured contact angle is approximately 100° or more. In this case, as shown in Figure 10 (E), it can be seen that the tip is not properly formed at the end of the microneedle (14), and the microneedle formation rate is approximately 20%, which is very low.

[0084] In addition, Fig. 10 (B) shows that the content of the hydrophilic polymer is 5 wt% to 20 wt%, and the measured contact angle is approximately 90° to 100°. In this case, as shown in Fig. 10 (F), it can be seen that the tip is normally formed at the end of the microneedle (14), and the microneedle formation rate is approximately 100%, indicating that almost all microneedles are normally formed.

[0085] Likewise, (C) of Fig. 10 shows that the content of the hydrophilic polymer is 20 wt% to 40 wt%, and the measured contact angle is approximately 70° to 90°. In this case, as shown in (G) of Fig. 10, it can be seen that the tip is normally formed at the end of the microneedle (14), and the microneedle formation rate is approximately 100%, indicating that almost all microneedles are normally formed.

[0086] Meanwhile, (D) of Fig. 10 corresponds to a content of hydrophilic polymer exceeding 40 wt%, and the measured contact angle corresponds to approximately 60° or less. In this case, as shown in (H) of Fig. 10, it can be seen that the microneedles (14) are not properly formed, and the microneedle formation rate corresponds to approximately 40%, which is very low.

[0087] Meanwhile, the viscosity of the hydrophilic polymer included in the adhesive composition may be 5 mPa·s to 5,000 mPa·s.

[0088] Fig. 11 is a photograph showing the degree of formation of microneedles (14) according to the viscosity of the hydrophilic polymer when a microneedle patch is produced by the blowing tension method according to Fig. 5.

[0089] (A) of Fig. 11 shows that the viscosity of the hydrophilic polymer is approximately 5 mPa·s to 1,000 mPa·s, and in this case, it can be seen that the tip is normally formed at the end of the microneedle (14), and the microneedle formation rate is approximately 100%, so it can be seen that almost all microneedles are normally formed.

[0090] In addition, (B) of Fig. 11 shows that the viscosity of the hydrophilic polymer is approximately 3,000 mPa·s to 5,000 mPa·s, and in this case, it can be seen that the tip is normally formed at the end of the microneedle (14), and the microneedle formation rate is approximately 95%, so it can be seen that almost all microneedles are normally formed.

[0091] On the other hand, (C) and (D) of FIG. 11 show that the viscosity of the hydrophilic polymer is approximately 10,000 mPa·s to 14,000 mPa·s and 30,000 mPa·s to 45,000 mPa·s, respectively, and in this case, it can be seen that the tip is not formed normally at the end of the microneedle (14), and the microneedle formation rate is approximately 65% ​​and 50%, respectively, indicating that the microneedle is not formed normally.

[0092] While the present invention has been described above with reference to preferred embodiments, those skilled in the art will appreciate that various modifications and variations can be made to the present invention without departing from the spirit and scope of the invention as defined in the claims below. Therefore, any modified implementation that fundamentally includes the elements of the claims should be considered within the technical scope of the present invention.

[0093] The present invention relates to a microneedle patch and an adhesive composition, and more particularly, to a microneedle patch and an adhesive composition in which the microneedles can be directly attached to an adhesive sheet without a support film supporting the hydrophilic microneedles when providing the microneedle patch.

Claims

1. Adhesive sheet; A hydrophilic microneedle provided on the adhesive sheet; A microneedle patch, characterized in that the microneedles are directly connected to one surface of the adhesive sheet.

2. In paragraph 1, The above hydrophilic microneedles are composed of multiple pieces, A microneedle patch characterized in that the adhesive sheet is exposed between the plurality of microneedles.

3. In paragraph 1 or 2, A microneedle patch, characterized in that the adhesive sheet comprises a hydrophilic polymer.

4. In paragraph 3, The above adhesive sheet It is formed of an adhesive composition including the hydrophilic polymer and an adhesive, and includes an adhesive layer to which the microneedles are connected, and a film layer provided under the adhesive layer. A microneedle patch, characterized in that the hydrophilic polymer is contained in an amount of 5 to 40 wt% in the adhesive composition.

5. In paragraph 3 A microneedle patch characterized in that the hydrophilic polymer is composed of one or a mixture of two or more selected from CMC (carboxymethyl cellulose), Carbomer, HPMC (hydroxypropyl methyl cellulose), PVP (polyvinyl pyrrolidone), PVA (polyvinyl alcohol), and Guar Gum.

6. In paragraph 4, The above adhesive A microneedle patch characterized by containing 10 to 50 wt% of synthetic rubber, 30 to 70 wt% of hydrogenated hydrocarbon resin, 5 to 20 wt% of mineral oil, and 0.2 to 3 wt% of an antioxidant.

7. In paragraph 3, A microneedle patch, characterized in that the contact angle of the adhesive sheet is 70° to 100°.

8. In paragraph 3, A microneedle patch, characterized in that the viscosity of the hydrophilic polymer is 5 mPa·s to 5,000 mPa·s.

9. An adhesive composition that forms an adhesive layer of an adhesive sheet included in a microneedle patch, An adhesive composition characterized in that the composition comprises a hydrophilic polymer.

10. In paragraph 9, An adhesive composition characterized in that the hydrophilic polymer is composed of one or a mixture of two or more selected from CMC (carboxymethyl cellulose), Carbomer, HPMC (hydroxypropyl methyl cellulose), PVP (polyvinyl pyrrolidone), PVA (polyvinyl alcohol), and GuarGum.

11. In paragraph 9, An adhesive composition, characterized in that the hydrophilic polymer is contained in an amount of 5 to 40 wt%.

12. In paragraph 9, The above composition comprises an adhesive and the hydrophilic polymer, The above adhesive An adhesive composition comprising 10 to 50 wt% of synthetic rubber, 30 to 70 wt% of hydrogenated hydrocarbon resin, 5 to 20 wt% of mineral oil, and 0.2 to 3 wt% of an antioxidant.

13. In paragraph 9, An adhesive composition, characterized in that the viscosity of the hydrophilic polymer is 5 mPa·s to 5,000 mPa·s.

Images