Novel antifouling imaging coating material, preparation method therefor and use thereof

Abstract

A novel antifouling imaging coating material, a preparation method therefor and a use thereof. In the structure of the antifouling imaging coating material, platinum nanoparticles are bonded to a modified phosphorylcholine polymer, the modified phosphorylcholine polymer part is used as an antifouling unit, and the platinum nanoparticles are used as imaging units, so that the antifouling imaging coating material has both excellent antifouling performance and imaging performance. In addition, a siloxane group in the antifouling unit can form covalent bonding with the surface of a substrate, so that the coating is firmly bonded onto the substrate, ensuring the bonding stability and safety of the antifouling imaging coating material on the substrate, improving the durability and reliability of the imaging coating, and achieving wide application prospects.

Description

A new antifouling developing coating material and its preparation method and application Technical Field

[0001] The present application belongs to the technical field of medical materials and relates to a novel anti-fouling developing coating material and a preparation method and application thereof. Background Art

[0002] Medical developer coatings play a crucial role in medical imaging. With the continuous advancement of medical imaging, the requirements for developer coatings are increasing. They must not only provide excellent development capabilities but also possess superior anti-fouling capabilities, resisting bacterial protein adhesion to prevent bacterial infection and cross-infection, while maintaining a clean and transparent surface to ensure clear and accurate images.

[0003] Medical antifouling coatings originate from improvements to traditional developing coatings. While these coatings provide developing capabilities, their antifouling properties are limited. With the increasing use of medical devices, the need for more pressing applications is driving research into adding antifouling materials to enhance antifouling performance. The antifouling principle primarily involves the hydrophilicity and lipophilicity of a material's surface. Hydrophilic surfaces create a high contact angle for water, preventing the retention of water and impurities, while lipophilic surfaces inhibit the adhesion of organic matter and oils, reducing the adsorption of biomolecules. Recent research on medical antifouling coatings has made significant progress. Researchers have developed exceptional antifouling coatings by manipulating surface properties. For example, the introduction of superhydrophobic polymers can impart a superhydrophobic effect to surfaces, achieving efficient self-cleaning and antifouling properties. Furthermore, biomimetic surface design, such as micro-nano-concave and convex surfaces and honeycomb structures, reduces surface contact area and reduces the adhesion of contaminants. Furthermore, the incorporation of bioactive molecules into the coating creates a "bacterial killing zone" that inhibits microbial growth, thereby enhancing antifouling effectiveness.

[0004] The developing performance of medical anti-fouling developer coatings has a crucial impact on the clarity and diagnostic accuracy of medical images. Developer coatings need to be sensitive to X-rays to ensure good development results under X-ray irradiation. Development technology is widely used in medical imaging, producing clear images through the development of imaging photosensitive materials. Among them, X-ray development is a commonly used technology that relies on the absorption and scattering of X-rays. Developer coatings play a key role in this process, producing images by absorbing and scattering X-rays. Research on medical developer coatings has continued to develop with the continuous advancement of medical imaging technology. Researchers have improved development efficiency and image quality by improving the chemical composition of developers and coatings.

[0005] However, the interaction between the developer and the antifouling agent may reduce the development efficiency, so the effective combination of development and antifouling functions remains a challenging problem that needs to be solved.

[0006] Summary of the Invention

[0007] The following is a summary of the subject matter described in detail herein. This summary is not intended to limit the scope of the claims.

[0008] In view of the shortcomings of the prior art, the purpose of this application is to provide a new anti-fouling and developing coating material and its preparation method and application. The anti-fouling and developing coating material of this application achieves an effective combination of developing function and anti-fouling function.

[0009] To achieve this goal, this application adopts the following technical solutions:

[0010] In one aspect, the present application provides a novel anti-fouling and developing coating material, wherein the anti-fouling and developing coating material has a structure as shown in the following formula I:

[0011] Wherein m=20, n=10, k=3, R is a siloxane group, and L is a connecting functional group.

[0012] The antifouling and developing coating material of this application comprises platinum nanoparticles linked to a modified phosphorylcholine polymer. The modified phosphorylcholine polymer serves as the antifouling unit, while the platinum nanoparticles serve as the developing unit. This results in the antifouling and developing coating material exhibiting both excellent antifouling and developing properties. Furthermore, the siloxane groups in the antifouling unit can form a covalent bond with the substrate surface, firmly bonding the coating to the substrate. This ensures the stability and security of the antifouling and developing coating material on the substrate, preventing it from fading or falling off over time. This significantly improves the durability and reliability of the developing coating, and has broad application prospects.

[0013] In the present application, m, n and k represent the number of structural units, wherein R in n structural units may be the same or different, and L in k structural units may be the same or different.

[0014] In some optional embodiments, m:n=1:1 to 4:1, for example, 1:1, 2:1, 3:1 or 4:1. In the present application, the ratio of m:n is within the range of 1:1 to 4:1.

[0015] In some alternative embodiments, R is selected from tris(trimethylsiloxy)silyl or trimethoxysilyl, the structures of which are as follows:

[0016] In some optional embodiments, L is selected from methylsilyl, vinylsilyl, aminosilyl, triphenylphosphine or -P(R)3, wherein R is an alkyl, olefin or mercapto group (i.e., a hydrocarbon phosphine ligand group or a mercaptophosphine ligand group).

[0017] In some optional embodiments, the platinum nanoparticles are bound to L through electrical interaction.

[0018] In some optional embodiments, the platinum nanoparticles electrically interact and bind to the amino group, thiol group, or phosphorus group in the L group.

[0019] On the other hand, the present application provides a method for preparing the novel anti-fouling developing coating material as described above, the preparation method comprising the following steps:

[0020] (1) preparing a modified phosphorylcholine polymer modified with siloxane and a linker functional group L;

[0021] (2) allowing the platinum nanoparticles to electrically interact with the connecting functional group L in the modified phosphorylcholine polymer modified with siloxane and the connecting functional group L obtained in step (1) to obtain the novel anti-fouling developing coating material.

[0022] In some optional embodiments, the preparation of the modified phosphorylcholine polymer modified with siloxane and the linking functional group L in step (1) comprises the following steps:

[0023] 2-methacryloyloxyethyl phosphorylcholine reacts with a siloxane compound and a compound with an L group to obtain a modified phosphorylcholine polymer modified with the siloxane and the connecting functional group L.

[0024] In some optional embodiments, the siloxane compound is methacryloxypropyltris(trimethylsiloxy)silane and / or 3-(methacryloxy)propyltrimethoxysilane.

[0025] In some optional embodiments, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to the siloxane compound is 1:1-8:1, for example, 1:1, 1.5:1, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1, 5:1, 5.5:1, 6:1, 6.5:1, 7:1, 7.5:1 or 8:1.

[0026] In some optional embodiments, the reaction of 2-methacryloyloxyethyl phosphorylcholine with the siloxane compound is carried out in the presence of 4-cyano-4-(thiobenzoyl)valeric acid.

[0027] In some optional embodiments, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to 4-cyano-4-(thiobenzoyl)pentanoic acid is 1:1-5:1, for example, 1:1, 1.5:1, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1 or 5:1.

[0028] In some optional embodiments, the reaction of 2-methacryloyloxyethyl phosphorylcholine with the siloxane compound is carried out in the presence of azobisisobutyronitrile.

[0029] In some optional embodiments, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to azobisisobutyronitrile is 1:1-5:1, for example, 1:1, 1.5:1, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1 or 5:1.

[0030] In some optional embodiments, the compound having an L group is a compound having an L group and a carbon-carbon unsaturated bond.

[0031] In some optional embodiments, the compound carrying an L group is allyltriphenylphosphine bromide or propyltriphenylphosphine bromide.

[0032] In some optional embodiments, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to the compound carrying an L group is 2:1-8:1, for example, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1, 5:1, 5.5:1, 6:1, 6.5:1, 7:1, 7.5:1 or 8:1.

[0033] In one embodiment, the reaction temperature of step (1) is 60°C-70°C (e.g., 60°C, 63°C, 65°C, 68°C or 70°C), and the reaction time is 16-64h (e.g., 16h, 18h, 20h, 24h, 28h, 30h, 36h, 40h, 42h, 48h, 50h, 55h, 58h, 60h or 64h).

[0034] In one embodiment, the solvent for the reaction in step (1) is n-propanol.

[0035] In one embodiment, the reaction in step (1) is carried out under nitrogen protection.

[0036] In one embodiment, the more specific operation of step (1) is: dissolving 2-methacryloyloxyethyl phosphorylcholine, 4-cyano-4-(thiobenzoyl)valeric acid, and azobisisobutyronitrile in n-propanol, slowly heating to 60-70° C. under nitrogen protection, stirring and reacting for 16-32 hours, then adding a siloxane compound and a compound with an L group, and continuing the reaction for 16-32 hours to obtain the modified phosphorylcholine polymer modified with siloxane and the connecting functional group L.

[0037] In one embodiment, after the reaction in step (1) is completed, a post-processing step is further included, wherein the post-processing step is to precipitate the obtained reaction solution in ether, filter and dry it.

[0038] In one embodiment, the mass ratio of the modified phosphorylcholine polymer modified with siloxane and the linking functional group L obtained in step (1) to the platinum nanoparticles in step (2) is (1-3):(3-1), for example, 1:1, 1:1.5, 1:2, 1:2.5, 1:3, 1.5:1, 1.8:1, 2:1, 2.5:1 or 3:1.

[0039] In one embodiment, the combining in step (2) is performed under stirring at room temperature, and the stirring time is 6-12 h, such as 6 h, 7 h, 8 h, 9 h, 10 h, 11 h or 12 h.

[0040] In another aspect, the present application provides use of the novel antifouling developing coating material described above in coating a substrate surface.

[0041] In one embodiment, the substrate surface includes a silicon-based surface, a glass-based surface, a metal-based surface, or a polymer-based surface.

[0042] The material of the present application can be applied to the surfaces of various substrates, including glass substrates, metal substrates and various plastic and polymer substrates (silicone rubber, polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyurethane, etc.).

[0043] The new anti-fouling developing coating material of the present application has universal applicability. It combines with the hydroxyl groups on the surface of the substrate through silicon-oxygen bonds and can be covalently bonded to any silicon-based substrate, including various silicon-based surfaces such as glass, silicone sheets, and marble. It combines with other substrate surfaces through hydrophobic effects or van der Waals forces, and is widely applicable to different clinical and laboratory scenarios to meet the needs of different users.

[0044] On the other hand, the present application provides an anti-fouling developing coating, wherein the raw materials for preparing the anti-fouling developing coating include the novel anti-fouling developing coating material as described above.

[0045] On the other hand, the present application provides the use of the novel antifouling developing coating material as described above in medical devices or medical materials, optical lenses or industrial printing.

[0046] Compared with the prior art, this application has the following beneficial effects:

[0047] First of all, the new antifouling developing coating material of this application has been successfully applied to medical devices, forming an antifouling coating with excellent antifouling properties; compared with traditional developing coatings, it has achieved significant improvement in antifouling. The coating contains modified phosphorylcholine polymer as a unique antifouling agent component, which can effectively resist the attachment of bacterial proteins and prevent bacterial infection and cross-infection. This feature is crucial for medical safety, ensuring that medical equipment remains hygienic and safe during use. It can be applied to various medical scenarios, especially for equipment requiring high hygiene standards such as operating rooms and medical catheters. It is of special importance.

[0048] Secondly, platinum nanoparticles serve as developing units, enabling the new anti-fouling developing coating material of this application to exhibit excellent developing effects. Compared with traditional developing coatings, its surface is in the form of an elastomeric coating that is insoluble in water and will not be lost into the human body's own metabolism, ensuring the stability and durability of the developing effect, thereby eliminating the side effects that may be caused by the developing coating and improving the safety of medical developing coatings, which has positive significance for patients' health and medical experience.

[0049] In addition, the new anti-fouling developing coating material of the present application is universal. It can be covalently bonded to any silicon-based substrate through silane bonds with the hydroxyl groups on the surface of the substrate, including various silicon-based surfaces such as glass, silicone sheets, and marble; it can be bonded to other substrate surfaces through hydrophobic effects or van der Waals forces, and is widely applicable to different clinical and laboratory scenarios to meet the needs of different users. Its preparation method is simpler and lower in cost than traditional coatings, providing a feasible path for large-scale application of developing coatings.

[0050] Still other aspects will become apparent upon reading and understanding the accompanying drawings and detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0051] The accompanying drawings are used to provide a further understanding of the technical solution of this article and constitute a part of the specification. Together with the embodiments of this application, they are used to explain the technical solution of this article and do not constitute a limitation on the technical solution of this article.

[0052] FIG1 is a hydrogen nuclear magnetic spectrum (400 MHz, deuterated chloroform) of the novel antifouling developing coating material of Example 1;

[0053] FIG2A is a graph showing the results of an anti-protein adhesion test of the novel anti-fouling developing coating material of Example 1;

[0054] FIG2B is a graph showing the results of fluorescence quantitative analysis of the total amount of protein molecules adsorbed by the novel antifouling and developing coating material of Example 1;

[0055] FIG3A is a graph showing the results of an antibacterial adhesion test of the novel antifouling developing coating material of Example 1;

[0056] FIG3B is a quantitative analysis result of bacterial colonies adsorbed by the novel antifouling developing coating material of Example 1;

[0057] FIG4A is a graph showing the results of an anti-platelet adhesion test of the novel anti-fouling developing coating material of Example 1;

[0058] FIG4B is a quantitative analysis result of the number of platelets adhered to the novel anti-fouling developing coating material of Example 1;

[0059] FIG5 is an X-ray imaging development effect diagram of the novel antifouling developing coating material of Example 1 on a polyurethane sheath; wherein AC are X-ray imaging development effect diagrams when the mass ratio of the antifouling functional polymer modified phosphorylcholine to platinum nanoparticles of the coating is 2:1, 1:1, and 1:2, respectively, and D is an X-ray imaging development effect diagram of the blank control group;

[0060] FIG6 is a graph showing the results of quantitative analysis of the development intensity of the X-ray imaging development effect of the novel anti-fouling development coating material of Example 1 on a polyurethane sheath. DETAILED DESCRIPTION

[0061] The technical solution of the present application is further described below through specific implementation methods. Those skilled in the art should understand that the embodiments are only used to help understand the present application and should not be regarded as specific limitations of the present application.

[0062] Example 1

[0063] This embodiment provides a novel anti-fouling developing coating material, which is prepared by a method comprising the following steps.

[0064] 1) 0.75 mol of 2-methacryloyloxyethyl phosphorylcholine, 0.4 mol of 4-cyano-4-(thiobenzoyl)valeric acid, and 0.4 mol of azobisisobutyronitrile were dissolved in n-propanol, and the temperature was slowly raised to 65° C. under nitrogen protection, and the reaction was stirred for 24 hours. Then, a mixture of 0.125 mol of methacryloyloxypropyl tris(trimethylsiloxy)silane and 0.075 mol of allyltriphenylphosphine bromide was added, and the reaction was continued for 24 hours. The obtained n-propanol solution was added to diethyl ether for precipitation, and filtered and dried to obtain the obtained product; the reaction is shown below, and the resulting polymer NMR is shown in Figure 1, and a methoxysilane peak is detected at 3.55 ppm.

[0065] 2) Platinum nanoparticles are thoroughly dispersed in a methanol / water binary solution and then mixed with an antifouling functional polymer, modified phosphorylcholine, in a 1:2 mass ratio in the methanol / water binary solvent. The mixture is stirred at room temperature for 6 hours to allow for complete hydrolysis and polymerization of the silyl groups of the modified phosphorylcholine, thereby forming an antifouling and developing polymer, or antifouling and developing coating material, that can be applied to any silicon-based substrate. The structure of this antifouling and developing coating material is shown below:

[0066] Wherein, m=20, n=10, k=3; platinum nanoparticles are combined with triphenylphosphine through electrical interaction.

[0067] Example 2

[0068] The antifouling and developing coating material of Example 1 was used to test protein adhesion. Regarding protein adsorption resistance, the adsorption capacity of fibrin (FIB), serum albumin (HB), and collagen (Col) on the antifouling and developing coating was measured and characterized. The antifouling and developing coating used had a mass ratio of platinum nanoparticles to antifouling functional polymer-modified phosphorylcholine of 1:2, with a total concentration of 400 mg / mL. The protein molecules used were pre-modified with fluorescent molecules and adsorbed for 21 days. The adsorption of various molecules on the coating was observed using a fluorescence microscope (Nikon Eclipse TE / Ti) on days 3, 14, and 21 (labeled as day 3, day 7, and day 21 in Figures 2A and 2B). The control group was a blank control without the antifouling and developing coating. The results are shown in Figures 2A and 2B (uncoating in the figure indicates uncoated, coating indicates coated, and they have the same meaning in the following figures).

[0069] As shown in Figure 2A, the coating exhibited excellent protein resistance compared to the blank control. Serum proteins were barely adsorbed on the coating, and the amount of fibrin adsorbed on the anti-fouling and developing coating was also minimal, while the blank control was densely packed with protein molecules. Furthermore, fluorescence quantitative analysis of the total amount of adsorbed molecules was performed. As shown in Figure 2B, the total amount of protein adsorbed on the anti-fouling and developing coating was significantly reduced compared to the blank control, demonstrating the coating's exceptional protein resistance.

[0070] Example 3

[0071] The anti-fouling developer coating material of Example 1 was used to test its antibacterial adhesion. The antibacterial adsorption capacity of the anti-fouling developer polymer coating was characterized using Candida albicans (C. albicans), Escherichia coli (E. coli), and Staphylococcus aureus (S. aureus). The anti-fouling developer coating used a 1:2 mass ratio of platinum nanoparticles to anti-fouling functional polymer-modified phosphorylcholine, with a total concentration of 400 mg / mL. The samples were immersed in three high-concentration (108 / mL) bacterial solutions for two weeks, then removed and air-dried. The bacterial counts were observed using a scanning electron microscope (SEM). The bacterial solution consisted of live bacteria, and the solvent was dialysate. The live bacteria were replaced every three days to ensure bacterial activity. A blank control group was used. The results are shown in Figures 3A and 3B.

[0072] As shown in Figure 3A, after two weeks of adsorption of three different bacteria, large colonies were evident on the control sample without the anti-fouling developer coating, while no significant bacterial growth was observed on the sample coated with the anti-fouling developer coating. Furthermore, quantitative analysis of the adsorbed colonies, as shown in Figure 3B, revealed that the anti-fouling developer coating significantly reduced bacterial adhesion, with the reduction reaching 95% after two weeks.

[0073] Example 4

[0074] The anti-fouling developing coating material of Example 1 was used to conduct an anti-platelet adhesion test. The anti-fouling developing coating was coated on different matrix materials, namely NiTi, PVC and TPU, respectively. The platelets were contacted with the materials to be tested, and then washed and observed with SEM (S-3400N) to observe the effect of the anti-fouling developing coating on platelet adhesion. The control group was a blank negative control, and the mass ratios of the anti-fouling functional polymer modified phosphorylcholine and platinum nanoparticles in the experimental group were 2:1, 1:1 and 1:2 respectively. The results are shown in Figures 3A and 3B. As shown in Figure 4A, the developing anti-fouling coating had obvious anti-platelet adhesion effects on all three materials. The number of adhered platelets was quantitatively analyzed, and the results are shown in Figure 4B. It can be found that the anti-platelet adhesion effect is significantly enhanced with the increase of the proportion of anti-fouling functional polymer modified phosphorylcholine.

[0075] Example 5

[0076] The antifouling and developing coating material from Example 1 was applied to a medical polyurethane sheath. The experimental groups used a 2:1, 1:1, and 1:2 mass ratio of the antifouling functional polymer-modified phosphorylcholine to platinum nanoparticles, respectively, at a total concentration of 400 mg / mL. The control group served as a blank negative control. The results are shown in Figure 5 , where Figures A to C show the three different mixing ratios of the developing antifouling coating, all of which exhibited significant developing effects on the polyurethane sheath. Figure D shows the results of the control group. Analysis of developing intensity, as shown in Figure 6, reveals that the developing intensities for the 2:1, 1:1, and 1:2 mass ratios were similar, each 3-4 times that of the control group.

[0077] From the above description, it can be seen that the antifouling and developing coating material of the present application has excellent coating performance, antifouling performance and X-ray developing effect.

[0078] The modified phosphorylcholine polymer portion of the antifouling and developing coating material of the present application serves as an antifouling unit, and the adsorbed platinum nanoparticles serve as developing units. The antifouling functional polymer modified phosphorylcholine and the platinum nanoparticles are bonded through electrical interactions, and simultaneously exhibit excellent antifouling and developing properties. The siloxane group in the antifouling unit can form a covalent bond with the substrate surface, thereby firmly bonding the coating to the substrate, ensuring the binding stability and safety of the antifouling and developing coating material of the present application on the substrate. For example, the siloxane group can covalently bond with the silicon-based substrate material, exhibiting excellent stability and preventing loss or detachment over time, significantly improving the durability and reliability of the developing coating. The siloxane group can also bond with other substrate surfaces through hydrophobic interactions and van der Waals forces, thereby providing flexibility and applicability for a wide range of developing coating applications. The anti-fouling and developing coating material of the present application can be coated on the surfaces of various substrates, including silicon-based substrates (such as glass substrates), metal substrates, and various plastic and polymer substrates (such as silicone rubber, polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyurethane, etc.), and has a wide range of applicability; it can be used in a wide range of fields, for example, in medical devices, optical lenses and industrial printing. The coating gives the coated object the dual functions of anti-fouling and X-ray imaging, and exhibits excellent X-ray absorption performance during development, especially providing accurate and clear development effects for medical imaging, and providing reliable imaging information for medical imaging.

[0079] Anything not described in detail in this application is well-known to those skilled in the art.

[0080] The applicant declares that while the above-mentioned embodiments are used to illustrate the process of the present application, the present application is not limited to the above-mentioned process steps, which does not mean that the present application must rely on the above-mentioned process steps in order to be implemented. Those skilled in the art should understand that any improvements to the present application, equivalent replacements for the raw materials used in the present application, addition of auxiliary components, and selection of specific methods, etc., fall within the scope of protection and disclosure of the present application.

Claims

1. A novel anti-fouling and developing coating material has a structure shown in the following formula I: where m = 20, n = 10, k = 3, R is a siloxane group, and L is a linking functional group.

2. The novel anti-fouling and developing coating material according to claim 1, wherein, m:n = 1:1 to 4:

1.

3. The novel anti-fouling and developing coating material according to claim 1 or 2, wherein, R is selected from tris(trimethylsilyloxy)silyl or trimethoxysilyl, and its structure is as follows:

4. The novel anti-fouling and developing coating material according to any one of claims 1-3, wherein, L is selected from methylsilyl, vinylsilyl, aminosilyl, triphenylphosphino, or -P(R)3, where R is an alkyl group, an alkenyl group, or a mercapto group.

5. The novel anti-fouling and developing coating material according to any one of claims 1-4, wherein, The platinum nanoparticles and L are bound by an electrostatic interaction; Optionally, the platinum nanoparticles and the amino group, mercapto group, or phosphino group in the L group are bound by an electrostatic interaction.

6. A method for preparing a novel antifouling and developing coating material according to any one of claims 1-5, comprising the following steps: (1) Prepare a modified choline phosphate polymer modified with a siloxane and a linking functional group L; (2) Bind the platinum nanoparticles to the linking functional group L in the modified choline phosphate polymer modified with a siloxane and a linking functional group L obtained in step (1) by an electrostatic interaction to obtain the novel antifouling and developing coating material.

7. The preparation method according to claim 6, wherein, The preparation of the modified choline phosphate polymer modified with a siloxane and a linking functional group L in step (1) comprises the following steps: 2-methacryloyloxyethyl phosphorylcholine reacts with a siloxane compound and a compound with an L group to obtain a modified choline phosphate polymer modified with a siloxane and a linking functional group L; Optionally, the siloxane compound is methacryloyloxypropyl tris(trimethylsiloxy)silane and / or 3-(methacryloyloxy)propyltrimethoxysilane; Optionally, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to the siloxane compound is 1:1 - 8:1; Optionally, the reaction of 2-methacryloyloxyethyl phosphorylcholine with the siloxane compound is carried out in the presence of 4-cyano-4-(thiobenzoyl)valeric acid; Optionally, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to 4-cyano-4-(thiobenzoyl)valeric acid is 1:1 - 5:1; Optionally, the reaction of 2-methacryloyloxyethyl phosphorylcholine with the siloxane compound is carried out in the presence of azobisisobutyronitrile; Optionally, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to azobisisobutyronitrile is 1:1 - 5:1; Optionally, the compound with an L group is a compound with an L group and a carbon-carbon unsaturated bond compound; Optionally, the compound with an L group is allyl triphenylphosphonium bromide or propyl triphenylphosphonium bromide; Optionally, the molar ratio of 2-methacryloyloxyethyl phosphorylcholine to the compound with an L group is 2:1 - 8:1; Optionally, the temperature of the reaction in step (1) is 60°C - 70°C, and the reaction time is 16 - 64 h; Optionally, the solvent for the reaction in step (1) is n-propanol; Optionally, the reaction in step (1) is carried out under nitrogen protection; Optionally, the more specific operation of step (1) is as follows: Dissolve 2-methacryloyloxyethyl phosphorylcholine, 4-cyano-4-(thiobenzoyl) pentanoic acid, and azobisisobutyronitrile in n-propanol, slowly heat up to 60-70 °C under nitrogen protection, stir and react for 16-32 h, then add a siloxane compound and a compound with group L, and continue to react for 16-32 h to obtain the modified phosphorylcholine polymer modified with siloxane and linking functional group L; Optionally, after the reaction in step (1) is completed, a post-treatment step is further included, and the post-treatment step is to precipitate the obtained reaction solution in ether, filter and dry; Optionally, the mass ratio of the modified phosphorylcholine polymer modified with siloxane and linking functional group L obtained in step (1) to the platinum nanoparticles described in step (2) is (1-3):(3-1); Optionally, the combination in step (2) is completed under stirring at room temperature, and the stirring time is 6-12 h.

8. Application of the novel anti-fouling and developing coating material according to any one of claims 1-5 in coating the surface of a substrate; Optionally, the surface of the substrate includes a silicon-based surface, a glass substrate surface, a metal substrate surface, and a polymer substrate surface.

9. An anti-fouling and developing coating, the preparation raw materials of which include the novel anti-fouling and developing coating material according to any one of claims 1-5.

10. Application of the novel anti-fouling and developing coating material according to any one of claims 1-5 in medical devices or medical materials, optical lenses or industrial printing.

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