Microsphere drying, curing and forming method and device

Abstract

The present invention relates to the technical field of microsphere manufacturing, and specifically relates to a microsphere drying, curing and forming method and device. The device comprises a reactor, the inside of the reactor being provided with: a filter device, which comprises a filter basket; an air pressure control portion, which comprises an air intake portion and an air exhaust portion and is used for controlling air pressure in the reactor, wherein the air intake portion comprises an air inlet disposed below the filter basket and can realize air-blowing drying of materials in the filter basket; and a heat exchange portion which is used for controlling the temperature in the reactor. Drying processes that can be realized include freeze drying, vacuum drying and air-blowing drying. The present invention can realize the filtering, washing and drying of microspheres, and can realize combined drying processes, the drying processes including air-blowing drying, vacuum drying and freeze drying; thus, the present invention has the advantages of wide applicability and high integration, and can adapt to mass production of microspheres.

Description

Microsphere drying and curing molding method and device Technical Field

[0001] The present invention relates to the technical field of microsphere manufacturing, and in particular to a microsphere drying, curing and molding method and device. Background Art

[0002] The curing process for microspheres requires filtering out smaller microspheres before drying and curing to ensure the microspheres meet the required particle size. Existing microsphere curing equipment only offers a single drying and curing process, making it difficult to implement a complex drying and curing process, resulting in poor applicability. Summary of the Invention

[0003] To overcome the shortcomings of the prior art, the present invention provides a microsphere drying and curing molding method and apparatus, which can implement a composite drying and curing process, ensuring the quality of the microsphere curing molding. The method is suitable for batch production of microsphere solid materials in the pharmaceutical industry.

[0004] In order to achieve the above-mentioned purpose, the present invention is implemented through the following technical solutions: A microsphere drying, curing and molding device, comprising: a reactor, wherein the reactor is provided with: a filtering device, comprising a filter basket; an air pressure control unit, wherein the air pressure control unit comprises an air intake unit and an air extraction unit, for controlling the air pressure in the reactor; the air intake unit comprises an air inlet arranged below the filter basket, which can blow air to dry the material in the filter basket; a heat exchange unit, for controlling the temperature in the reactor; the drying processes that can be realized include freeze drying, vacuum drying and air blowing drying.

[0005] Based on the above device, when freeze-drying is performed, the heat exchange part cools down the inside of the reactor. When vacuum drying is performed, the air pressure control part evacuates the reactor. During the drying process, water vapor evaporates through the air pressure control part to ensure the balance of air pressure in the reactor. The air pressure control part can adjust the positive and negative pressures of the air pressure in the reactor. The air intake part intakes air to adjust the positive pressure; the air extraction part extracts air to adjust the negative pressure. During the process of air blowing drying at the air inlet, the air intake and extraction volumes of the air intake and extraction parts are kept balanced to achieve air pressure balance in the reactor during the drying process. The filter basket is used to receive and filter the microsphere material entering the reactor.

[0006] A microsphere drying and solidification molding method based on the above-mentioned device includes the following steps: Step S1, a washing process, in which the microspheres are input into a reactor, washing liquid is added, and the microspheres are rinsed and / or soaked for washing. At the same time, the temperature of the washing process can be controlled within a preset range by a heat exchange device; Step S2, a filtration process, in which excess detergent and microspheres smaller than a preset particle size are filtered out by the filter basket; Step S3, a drying process, in which the microsphere material in the reactor is dried. According to the characteristics of different microsphere materials, one or more drying processes of freeze drying, vacuum drying, and air blowing drying are selected to achieve a moisture content of the microspheres below a preset value.

[0007] Furthermore, in the microsphere drying, curing and forming device described in the present application, the exhaust portion includes an exhaust port arranged above the filter basket.

[0008] Furthermore, in the microsphere drying, curing, and molding device described herein, the reactor comprises a barrel and a lid, the lid having a sealing cover mounted on the barrel, the lid being provided with a feed port and the air extraction port. As a preferred embodiment of the present invention, the lid is sealed to the barrel to ensure controllable air pressure within the reactor, and the feed port is used to input microsphere material and washing liquid.

[0009] Furthermore, the microsphere drying, curing, and molding device described herein further includes a swing drive device, which is transmission-connected to the reactor and configured to drive the reactor to swing back and forth within a preset angle. As a preferred embodiment of the present invention, the swing drive device is configured to drive the reactor to swing during the washing and filtration steps, ensuring that the material is fully washed and filtered.

[0010] Furthermore, the microsphere drying and curing molding device described in the present application also includes a pipeline integrated disk, the pipeline integrated disk is arranged on the outside of the reactor, the pipeline integrated disk and the reactor are fixedly connected by a connecting shaft, the pipeline integrated disk is provided with a group of first rigid tubes, and the group of first rigid tubes is connected to the gas and liquid inlet and outlet of each pipeline on the reactor; it also includes a pipeline external disk, the pipeline external disk is fixedly arranged on the outside of the pipeline integrated disk away from the reactor, and a group of second rigid tubes is provided on the pipeline external disk, the first rigid tubes and the second rigid tubes correspond one to one, and the first rigid tubes and the second rigid tubes are connected by a hose. As a preferred embodiment of the present application, when the reactor rotates, the pipeline integrated disk is driven to rotate synchronously, and the pipeline external disk is stationary. Through the above-mentioned device, the reactor is prevented from being swung by the swing drive device, causing the tubes connected to the reactor to detach or rub against each other and even be damaged.

[0011] Furthermore, in the microsphere drying, curing, and molding device described in this application, a pair of bases are provided on either side of the reactor, the drive shaft and connecting shaft are rotatably mounted on the pair of bases, the pipeline external connection plate is fixed to the base proximal to the connecting shaft, and the swing drive device is mounted on the base proximal to the drive shaft. As a preferred embodiment of this application, the base is provided to support the reactor, and corresponding to the mounting positions of the drive shaft and connecting shaft, the base is provided with a bearing seat to ensure the stability of the reactor's swinging motion.

[0012] Furthermore, in the microsphere drying and solidification forming device described in the present application, the top of the filter basket is provided with an annular positioning plate extending radially outward, and the filter basket is detachably mounted on the cylinder via the annular positioning plate, with a gap provided between the side wall of the filter basket and the inner wall of the cylinder. As a preferred embodiment of the present application, the filter basket is hung on the cylinder as a whole via the annular positioning plate, with a gap provided between the filter basket and the inner wall of the cylinder to ensure that the washing liquid can flow out of the side wall during filtration, thereby improving the filtration efficiency. It should be noted that the annular positioning plate and the cylinder need to be relatively locked at least radially and axially.

[0013] Furthermore, the microsphere drying and curing molding device described in the present application is provided with an air collecting hood at the bottom of the inner cavity of the cylinder, the air collecting hood is arranged at the bottom of the filter basket, a sealing ring is arranged between the bottom of the filter basket and the air collecting hood, the air inlet is arranged on the air collecting hood, a liquid outlet cavity is arranged between the bottom of the air collecting hood and the bottom of the cylinder, the bottom of the cylinder is provided with a liquid outlet hole, and the liquid outlet hole is connected to the liquid outlet cavity. As a preferred embodiment of the present application, due to the accumulation of material at the bottom of the filter basket, when blowing air to the bottom of the filter basket, when the material blocks the bottom of the filter basket, the air flow will enter the filter basket from the side wall of the filter basket above the material accumulation, resulting in the blown air flow not being able to fully contact the material, thereby affecting the blowing and drying effect. By providing an air collecting hood and sealing the air collecting hood to the bottom of the filter basket through the sealing ring, the air inlet is arranged on the air collecting hood, so that the air inlet channel of the air inlet is isolated from the side wall of the filter basket by the air collecting hood. In this case, when blowing, the air flow can only pass through the filter basket from the bottom of the filter basket, which can ensure that the air flow is in full contact with the material and improve the blowing and drying effect. When discharging liquid, the solution discharged from the side wall of the filter basket flows from the gap between the side wall of the filter basket and the cylinder to the liquid outlet cavity and then discharged from the liquid outlet hole, and the solution discharged from the bottom of the filter basket is still discharged from the air inlet.

[0014] Furthermore, in the microsphere drying and curing molding device described in the present application, an insulation shell is provided on the outside of the reactor, a heat exchange chamber is provided on the inside of the insulation shell, the heat exchange chamber is coated on the outside of the reactor inner cavity wall shell, and the heat exchange chamber includes vertically stacked compartments, and adjacent compartments are interconnected. As a preferred embodiment of the present application, the heat exchange chamber is used to pass a heat exchange medium to control the temperature within the reactor. By providing a partition in the heat exchange chamber, the heat exchange chamber is divided into a group of compartments, and the compartments are annular and cylindrical, which can ensure uniform heat transfer.

[0015] It can be seen from the above technical solution that the present invention has the following beneficial effects: The present invention provides a microsphere drying and solidification molding device, which can realize the filtration, washing and drying of microsphere solutions, and can realize a composite drying process including air blowing drying, vacuum drying and freeze drying. It has the advantages of wide applicability and high integration, and can adapt to the mass production of microspheres. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is a schematic diagram of the three-dimensional structure of a microsphere drying and curing molding device described in an embodiment of the present application; Figure 2 is a schematic diagram of the internal structure of the reactor described in an embodiment of the present application; Figure 3 is a partial enlarged view of the circle B area in Figure 2; Figure 4 is a schematic diagram of the vibration generating part described in an embodiment of the present application; Figure 5 is a partial enlarged view of the circle A area in Figure 4; Figure 6 is a schematic diagram of the air outlet plate described in an embodiment of the present application.

[0017] In the figure: 1-reactor; 11-cylinder; 111-air inlet; 112-liquid outlet chamber; 113-liquid outlet hole; 12-cover; 121-feeding port; 122-exhaust port; 13-driving shaft; 14-connecting shaft; 15-gas collecting hood; 16-sealing ring; 17-air outlet plate; 171-air outlet hole; 18-insulation shell; 19-heat exchange chamber; 191-partition chamber; 192-liquid inlet; 193-liquid outlet; 2-filter basket; 21-annular positioning plate; 3-stirring paddle; 4-swinging drive device; 5-pipeline integrated disk; 51-first rigid tube body; 6-pipeline external connection disk; 61-second rigid tube body; 7-base; 8-vibration generating part; 81-air hammer; 82-pad. DETAILED DESCRIPTION

[0018] Example 1 The solidification preparation of microsphere materials requires filtering out microspheres with smaller particle sizes from the microspheres, and then drying and solidifying them to ensure that the particle size of the prepared microspheres meets the requirements. In a laboratory environment, due to the small amount of material, small-particle impurities in the microsphere solution can be filtered out by rinsing and filtration. However, in the preparation of large quantities of microsphere solid materials, since the microsphere materials are in a piled state after filtration, it is difficult to ensure the uniformity of rinsing by simple rinsing and filtration alone, and it is impossible to effectively filter out impurities with smaller particle sizes. In this regard, a microsphere drying and solidification molding process is proposed for drying and solidifying the microsphere solution into microsphere dry powder, comprising the following steps: Step S1, a single washing and filtration, in which the microspheres are input into a reactor, washing liquid is added for rinsing, and impurities smaller than a preset particle size are filtered out; Step S2, a single drying, in which the microsphere material in the reactor is blown and dried until the moisture content of the microsphere material is lower than a preset value. During this process, the reactor is evacuated to ensure that the air pressure in the reactor is within a preset range; specifically, the blowing medium is nitrogen, and the moisture content of the microsphere material is required to be less than 2% after the single drying.

[0019] Step S3, secondary washing and filtration, adding washing liquid to the reactor for washing, filtering out impurities smaller than a preset particle size; in this embodiment, in step S1 and step S3, the particle size of the impurities filtered out is less than 15 microns.

[0020] Step S4, injecting liquid, adding a preset dose of water for injection; specifically, the dose of water for injection is based on just covering the microsphere material.

[0021] Step S5, secondary drying, freeze-drying the microsphere material in the reactor until the moisture content is lower than a preset value. Specifically, the moisture content of the microsphere dry powder obtained after secondary drying is required to be lower than 1%.

[0022] Based on the above method, the microsphere drying and solidification molding device described herein works by ensuring that impurities in the microsphere material are fully filtered through a primary washing and filtration process, a primary drying process, and a secondary washing and filtration process. During the primary drying process, simultaneous air extraction ensures that the air pressure in the reactor remains within a preset range, preventing the molecular structure from being damaged by environmental pressure during microsphere molding. The secondary drying process ensures the integrity of the resulting microsphere dry powder, thereby ensuring the quality of the microsphere solidification molding process. This device is suitable for the batch production of microsphere solid materials in the pharmaceutical industry.

[0023] In this embodiment, in step S2, the blowing port is provided at the bottom of the reactor corresponding to the location where the microsphere material is prevented, and the exhaust port is provided at the top of the reactor.

[0024] Blowing from the bottom and exhausting from the top can generate convection energy to ensure the stability of the air pressure.

[0025] In this embodiment, in step S2, the air pressure range in the reactor is [10 Pa, 1 bar).

[0026] If the air pressure in the reactor exceeds the above pressure range, the microspheres will be damaged.

[0027] In this embodiment, step S5 includes the following steps: Step S5.1: cooling, after a preset time, the temperature in the reactor is reduced to a first preset value; specifically, the first preset value is -30°C, and the cooling time is 0.5h.

[0028] Step S5.2: Pre-freezing, maintaining the temperature in the reactor at a first preset value within a preset time; specifically, the pre-freezing time is 4 hours.

[0029] Step S5.3: Evacuate the reactor to maintain the pressure at a second preset value by continuous evacuation; specifically, the second preset value is 10 Pa.

[0030] Step S5.4: Drying: While maintaining the reactor pressure at the second preset value, the reactor temperature is raised in stages, with each temperature maintained for a preset time until the temperature reaches the third preset value. Specifically, the heating process is divided into five stages, with temperatures of -15°C, -5°C, 5°C, 25°C, and 48°C, with the third preset value being 48°C. The heating time for each stage is 2 hours, and the temperature maintenance times for each stage are 6 hours, 6 hours, 10 hours, 10 hours, and 4 hours, respectively.

[0031] Under a continuous vacuum environment, the temperature is gradually increased to ensure that the microsphere material is fully dried and has intact performance.

[0032] Example 2: A microsphere drying and curing molding device described in conjunction with Figures 1 to 6 can implement the microsphere drying and curing molding process described in Example 1, comprising: a reactor 1, wherein the reactor 1 is provided with: a filtration device including a filter basket 2; an air pressure control unit, wherein the air pressure control unit includes an air inlet and an air extraction unit for controlling the air pressure within the reactor 1; the air inlet unit includes an air inlet 111 disposed below the filter basket 2, capable of blowing air to dry the material within the filter basket 2; a heat exchange unit for controlling the temperature within the reactor 1; in this embodiment, the air extraction unit includes an air extraction port 122 disposed above the filter basket 2. Possible drying processes include freeze drying, vacuum drying, and air drying.

[0033] Based on the above device, during freeze-drying, the heat exchange unit cools the reactor. During vacuum drying, the air pressure control unit evacuates the reactor. During the drying process, water vapor evaporates through the air pressure control unit, maintaining balanced air pressure within the reactor. The air pressure control unit is capable of regulating both positive and negative pressure within the reactor. The air inlet unit inlets air to adjust the positive pressure, while the air extraction unit extracts air to adjust the negative pressure. During the air-blow drying process at the air inlet, the air intake and extraction volumes of the air inlet and extraction units remain balanced, ensuring balanced air pressure within the reactor during the drying process. In this embodiment, the air inlet 111 serves both as an air outlet for blow-through drying and as a drain port for removing washing solution and impurities. Because draining and blowing are performed in two separate steps, switching between draining and blowing functions can be achieved simply by switching the piping connected to the air inlet 111. This provides the advantage of high integration. The filter basket 2 is used to receive and filter the microsphere material entering the reactor 1. Specifically, the pore size of the filter basket can be changed according to the particle size requirements of different microspheres.

[0034] A microsphere drying and solidification molding method based on the above-mentioned device includes the following steps: Step S1, a washing process, in which the microspheres are input into a reactor, washing liquid is added, and the microspheres are rinsed and / or soaked for washing. At the same time, the temperature of the washing process can be controlled within a preset range by a heat exchange device; Step S2, a filtration process, in which excess detergent and microspheres smaller than a preset particle size are filtered out by the filter basket; Step S3, a drying process, in which the microsphere material in the reactor is dried. According to the characteristics of different microsphere materials, one or more drying processes of freeze drying, vacuum drying, and air blowing drying are selected to achieve a moisture content of the microspheres below a preset value.

[0035] In this embodiment, the reactor 1 includes a cylinder 11 and a cover 12. The cover 12 is a sealing cover provided on the cylinder 11. The cover 12 is provided with a feed port 121 and an air extraction port 122. Based on the above device, the cover 12 is sealed and connected to the cylinder 11 to ensure that the air pressure in the reactor 1 is controllable. The feed port 121 is used to input the microsphere solution and the washing liquid.

[0036] In this embodiment, a stirring paddle 3 is further included. The stirring paddle 3 is rotatably mounted on the cover 12, and the blades of the stirring paddle 3 are arranged in the filter basket 2. The stirring paddle 3 is used to stir the material when performing the washing and filtering steps to improve the uniformity of washing.

[0037] This embodiment also includes a swing drive device 4, which is in transmission connection with the reactor 1 and is used to drive the reactor 1 to swing back and forth within a preset angle. During the washing and filtration steps, the swing drive device 4 is used to drive the reactor 1 to swing, ensuring that the material is fully washed and filtered. Specifically, the swing angle is ±60°. In this embodiment, the swing drive device 4 is a motor. A drive shaft 13 is fixed to the reactor 1 and is in transmission connection with the swing drive device 4. The motor drives the drive shaft 13 in forward and reverse rotation to achieve the swing of the reactor 1.

[0038] This embodiment also includes a pipeline integration tray 5, which is disposed outside the reactor 1 and fixedly connected to the reactor 1 via a connecting shaft 14. The pipeline integration tray 5 is provided with a set of first rigid tubes 51, which are connected to the gas and liquid inlets and outlets of each pipeline connection on the reactor 1. It also includes a pipeline external connection tray 6, which is fixedly disposed outside the pipeline integration tray 5 away from the reactor 1. The pipeline external connection tray 6 is provided with a set of second rigid tubes 61, the first rigid tubes 51 and the second rigid tubes 61 corresponding to each other, and connected by a hose. When the reactor 1 rotates, the pipeline integration tray 5 is driven to rotate synchronously, while the pipeline external connection tray 6 remains stationary. This device prevents the tubes connected to the reactor 1 from detaching or rubbing against each other, resulting in damage, when the reactor 1 is swung by the swing drive device 4.

[0039] In this embodiment, a pair of bases 7 are provided on either side of the reactor 1. The drive shaft 13 and the connecting shaft 14 are rotatably mounted on the bases 7. The pipeline external connection plate 6 is fixed to the base 7 near the connecting shaft 14. The swing drive device 4 is disposed on the base 7 near the drive shaft 13. The bases 7 are provided to support the reactor 1, corresponding to the mounting positions of the drive shaft 13 and the connecting shaft 14. A bearing seat is provided on the base 7 to ensure the stability of the swinging motion of the reactor 1.

[0040] As shown in Figure 4 , in this embodiment, the filter basket 2 is provided with a radially outwardly extending annular positioning plate 21 at the top. The filter basket 2 is removably mounted on the barrel 11 via the annular positioning plate 21, with a gap provided between the sidewalls of the filter basket 2 and the inner wall of the barrel 11. The annular positioning plate 21 allows the filter basket 2 to be integrally mounted on the barrel 11, with a gap provided between the inner wall of the barrel 11 to ensure that the washing liquid can flow out through the sidewalls during filtration, thereby improving filtration efficiency. It should be noted that the annular positioning plate 21 and the barrel 11 must be locked relative to each other at least radially and axially. In this embodiment, the gap is 2.5 mm. Specifically, the barrel 11 can be locked by providing a slot that matches the shape of the annular positioning plate 21 or by providing a connector (screw). It should be noted that if a slot is provided, the annular positioning plate 21 must be pressed into the slot of the barrel 11 via the cover 12 to achieve axial locking of the annular positioning plate 21.

[0041] As shown in FIG3 , in this embodiment, an air collecting hood 15 is provided at the bottom of the inner cavity of the cylinder 11, and the air collecting hood 15 is provided at the bottom of the filter basket 2. A sealing ring 16 is provided between the bottom of the filter basket 2 and the air collecting hood 15. The air inlet 111 is provided on the air collecting hood 15. A liquid outlet cavity 112 is provided between the bottom of the air collecting hood 15 and the bottom of the cylinder 11. A liquid outlet hole 113 is provided at the bottom of the cylinder 11, and the liquid outlet hole 113 is communicated with the liquid outlet cavity 112. Since the material is accumulated at the bottom of the filter basket 2, when blowing air to the bottom of the filter basket 2, when the material blocks the bottom of the filter basket 2, the airflow will enter the filter basket 2 from the side wall of the filter basket 2 above the material accumulation, resulting in the blown airflow being unable to fully contact the material, affecting the blowing and drying effect. By setting up an air collecting hood 15 and sealingly connecting the air collecting hood 15 to the bottom of the filter basket 2 through a sealing ring 16, the air inlet 111 is set on the air collecting hood 15, so that the air inlet channel of the air inlet 111 is isolated from the side wall of the filter basket 2 by the air collecting hood 15. In this case, when blowing, the air flow can only pass through the filter basket 2 from the bottom of the filter basket 2, which can ensure that the air flow is in full contact with the material and improve the air drying effect. When discharging liquid, the solution discharged from the side wall of the filter basket 2 flows from the gap between the side wall of the filter basket 2 and the cylinder 11 to the liquid outlet cavity 112 and then discharged from the liquid outlet 113. The solution discharged from the bottom of the filter basket 2 is still discharged from the air inlet 111. In this embodiment, the pipeline corresponding to the air inlet 111 is passed through the liquid outlet 113, that is, the liquid outlet 113 is annular. The air collecting hood 15 is welded to the bottom of the cylinder 11 through a support member (not shown) circumferentially arranged at the bottom of the air collecting hood 15.

[0042] During the air drying process, the airflow will be concentrated in the upper area of ​​the air inlet 111 for blowing, making it difficult for the material in other areas of the filter basket 2 to come into contact with the airflow, thereby affecting the uniformity of the air drying. As shown in Figure 6, in this embodiment, the air collecting hood 15 is provided with an air outlet plate 17, and the air outlet plate 17 is arranged below the filter basket 2. The air outlet plate 17 is provided with a group of air outlet holes 171, and the air outlet holes 171 are arranged in a radially divergent array corresponding to the center of the bottom of the filter basket 2. Specifically, the air outlet plate 17 is circular and adapted to the bottom of the filter basket 2. The air outlet holes 171 correspond to the center of the circle and radially diverge from the center to form 5 groups, each group having 4 holes in the circumferential direction. Therefore, the uniformity of the air drying can be improved.

[0043] As shown in Figure 2, in this embodiment, an insulation shell 18 is provided on the outside of the reactor 1, and a heat exchange chamber 19 is provided on the inside of the insulation shell 18. The heat exchange chamber 19 is covered on the outside of the inner wall shell of the reactor 1. The heat exchange chamber 19 includes vertically stacked compartments 191, and adjacent compartments 191 are interconnected. The heat exchange chamber 19 is used to pass heat exchange medium to control the temperature inside the reactor 1. The heat exchange chamber 19 is divided into a group of compartments 191 by arranging partitions in the heat exchange chamber 19. The compartments 191 are annular and cylindrical, which can ensure uniform heat transfer. In this embodiment, a liquid inlet 192 is provided at the bottom of the heat exchange chamber 19, and a liquid outlet 193 is provided at the top of the heat exchange chamber 19. The heat exchange medium is silicone oil.

[0044] A cold trap (not shown) is provided between the air extraction port 122 and the air extraction pump (not shown). The cold trap is used to condense moisture in the extracted gas to prevent moisture from entering the air extraction pump and causing rust and damage to the air extraction pump. Specifically, the operating temperature of the cold trap is -40°C.

[0045] As shown in FIG4 , the apparatus further includes a vibration generating unit 8, which includes an air hammer 81. The air hammer 81 is mounted on the reactor 1, and the striking head of the air hammer 81 extends into the outer side of the inner wall of the reactor 1 corresponding to the filter basket 2. A pad 82 is provided between the filter basket 2 and the inner wall of the reactor 1 at the position corresponding to the striking head of the air hammer 81. During the filtration, washing, and drying stages, the air hammer 81 is used to strike the inner shell of the reactor 1 and transmit the vibration to the filter basket 2 through the pad 82, thereby assisting the fine-sized microspheres to fall out of the sieve holes of the filter basket 2, achieving sufficient filtration to shorten the filtration time and improve the filtration efficiency. Furthermore, the air hammer 81 can assist in shaking off the standard-sized microspheres adhering to the side of the filter basket 2 during discharge, thereby improving the collection efficiency.

[0046] The technical principles of the present invention have been described above in conjunction with specific embodiments. These descriptions are intended solely to illustrate the principles of the present invention and are not to be construed in any way as limiting the scope of protection of the present invention. Based on the explanations herein, those skilled in the art will be able to conceive of other specific embodiments of the present invention without inventive effort, and such embodiments will fall within the scope of protection of the present invention.

Claims

1. A microsphere drying and solidifying forming device, characterized in that include: A reaction kettle (1), wherein the reaction kettle (1) is provided with: A filter device, comprising a filter basket (2); An air pressure control unit, comprising an air intake unit and an air extraction unit, and used to control the air pressure in the reaction kettle (1); The air inlet portion comprises an air inlet (111) arranged below the filter basket (2) and capable of blowing air to dry the material in the filter basket (2); A heat exchange part, used to control the temperature in the reaction kettle (1); The drying processes that can be realized include freeze drying, vacuum drying and air blowing drying; The air extraction portion comprises an air extraction port (122) arranged above the filter basket (2); An insulation shell (18) is provided on the outside of the reactor (1); the heat exchange portion is a heat exchange chamber (19) arranged on the inside of the insulation shell (18); the heat exchange chamber (19) is coated on the outside of the inner chamber wall shell of the reactor (1); the heat exchange chamber (19) includes vertically stacked compartments (191); adjacent compartments (191) are interconnected.

2. The microsphere drying and solidifying forming device according to claim 1, characterized in that: The reaction kettle (1) comprises a cylinder (11) and a cover (12); the cover (12) is sealed and arranged on the cylinder (11); and the cover (12) is provided with a feed port (121) and a gas extraction port (122).

3. A microsphere drying and solidifying forming device according to claim 1, characterized in that: Also includes: A swing drive device (4), the swing drive device (4) is in driving connection with the reaction kettle (1), and the swing drive device (4) is used to drive the reaction kettle (1) to swing back and forth as a whole within a preset angle.

4. A microsphere drying and solidifying forming device according to claim 3, characterized in that: It also comprises a pipeline integrated disk (5), the pipeline integrated disk (5) is arranged outside the reactor (1), the pipeline integrated disk (5) and the reactor (1) are fixedly connected via a connecting shaft (14), the pipeline integrated disk (5) is provided with a group of first rigid tube bodies (51), and the group of first rigid tube bodies (51) are connected to gas and liquid inlets and outlets connected to various pipelines on the reactor (1); The invention also comprises a pipeline external connection plate (6), wherein the pipeline external connection plate (6) is fixedly arranged on the outer side of the pipeline integrated plate (5) away from the reaction kettle (1), and a group of second rigid pipe bodies (61) are arranged on the pipeline external connection plate (6), wherein the first rigid pipe bodies (51) and the second rigid pipe bodies (61) correspond one to one, and the first rigid pipe bodies (51) and the second rigid pipe bodies (61) are connected by a hose.

5. A microsphere drying and solidifying forming device according to claim 4, characterized in that: A pair of seats (7) are provided on both sides of the reactor (1); the drive shaft (13) and the connecting shaft (14) are rotatably mounted on the pair of seats (7), respectively; the pipeline external connection plate (6) is fixed on the seat (7) near the side of the connecting shaft (14); and the swing drive device (4) is arranged on the seat (7) near the side of the drive shaft (13).

6. The microsphere drying and solidifying forming device according to claim 2, wherein: An annular positioning plate (21) extending radially outward is provided on the top of the filter basket (2); the filter basket (2) is detachably mounted on the cylinder (11) via the annular positioning plate (21); and a gap is provided between the side wall of the filter basket (2) and the inner wall of the cylinder (11).

7. The microsphere drying and solidifying forming device according to claim 6, wherein: A gas collecting hood (15) is provided at the bottom of the inner cavity of the cylinder body (11). The gas collecting hood (15) is arranged at the bottom of the filter basket (2). A sealing ring (16) is provided between the bottom of the filter basket (2) and the gas collecting hood (15). The air inlet (111) is arranged on the gas collecting hood (15). A liquid outlet cavity (112) is provided between the bottom of the gas collecting hood (15) and the bottom of the cylinder body (11). A liquid outlet hole (113) is provided at the bottom of the cylinder body (11), and the liquid outlet hole (113) is communicated with the liquid outlet cavity (112).

8. A method for drying and solidifying microspheres into a molded form, using a microsphere drying and solidifying molding device as described in claim 1, for drying and solidifying a microsphere solution into microsphere dry powder, characterized in that: It includes the following steps: Step S1, washing process: Input the microsphere solution into the reaction kettle, add the washing liquid, and perform rinsing and / or immersion washing. Meanwhile, the temperature of the washing process can be controlled within a preset range through the heat exchange device; Step S2, filtering process: Filter out the excess detergent and microspheres smaller than the preset particle size through the filter basket; Step S3, drying process: Dry the microsphere material in the reaction kettle. According to the characteristics of different microsphere materials, select one or more drying processes among freeze drying, vacuum drying, and blowing drying to make the moisture content of the microspheres lower than the preset value.

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