Mechanical thrombectomy device

Abstract

A mechanical thrombectomy device is provided. The mechanical thrombectomy device comprises: a support wire; a clot arrestor which has an expandable frame and which is connected to the support wire; and a locking member for coupling the support wire and the clot arrestor. The locking member has a first ring-shaped part at a semicylindrical first end portion and has a second ring-shaped part at a second end portion, and the first ring-shaped part and the second ring-shaped part can include clasps, each having a slit.

Description

mechanical thrombectomy device

[0001] The present invention relates to a thrombus removal device, and more particularly, but not exclusively, to a mechanical thrombus removal device used for removing thrombi in blood vessels.

[0002] Various methods exist to treat thrombosis in specific blood vessels within the body. Among these, mechanical thrombectomy devices are inserted into blood vessels to break up or remove the clot, restoring perfusion through the occluded vessel. Approved mechanical thrombectomy devices for this purpose include thrombus filters, thrombus aspiration devices, coil retrievers, and, more recently, stent retrievers.

[0003] Stent retriever devices are primarily used to remove acute thrombi in stroke patients. They involve deploying a self-expanding stent, typically made of wire mesh, into a blood vessel to capture the thrombus. The stent retriever then pulls on the supporting wire, allowing the clot to be retrieved from the patient. These devices require fluoroscopic visibility and the ability to capture, confine, or maintain the thrombus without damaging the narrow, tortuous vascular structure. Furthermore, they must not pose a risk during surgery.

[0004] Conventional stent retriever devices have a problem in that when the device is retrieved through a tortuous vascular structure, the strength of the connection between the thrombectomy device and the support wire is weakened due to increased fatigue caused by traction force and repeated deformation, which may lead to the detachment of the thrombectomy device and the support wire during surgery.

[0005] In addition, the existing stent retriever device did not have a structure that sufficiently secured strength at the connection point between the support wire and the thrombectomy device, so it could not optimally transmit the propulsive force and traction force from the support wire to the thrombectomy device.

[0006] Conventional thrombectomy devices have insufficiently strong connections between the support wire and the thrombectomy device, leading to problems with the support wire and thrombectomy device becoming disconnected during surgery. Furthermore, this problem prevented the support wire's traction and propulsion forces from being optimally transmitted to the thrombectomy device.

[0007] One object of the present invention to solve the above-described problem is to provide a thrombus removal device having high bonding strength by strengthening the bonding force between the support wire and the thrombus remover by providing a locking member between the support wire and the thrombus remover.

[0008] Another object of the present invention to solve the above-mentioned problem is to provide a thrombus removal device in which the strength of the joint between the support wire and the thrombus remover is maintained sufficiently high even when repeatedly deformed without increasing the radial profile of the joint between the support wire and the thrombus remover.

[0009] However, the problem to be solved by the present invention is not limited to this, and may be expanded in various ways without departing from the spirit and scope of the present invention.

[0010] According to one embodiment of the present invention for achieving the above-described object, a thrombectomy device is a mechanical thrombectomy device, comprising: a support wire; a clot arrestor having an expandable frame and connected to the support wire; and a locking part configured to couple the support wire and the clot arrestor; wherein the locking part may include a clasp having a first ring-shaped part at a first end of a semi-cylindrical shape and a second ring-shaped part at a second end, and in which slits are respectively formed in the first ring-shaped part and the second ring-shaped part.

[0011] According to one aspect, the clasp at least partially surrounds a proximal portion of the thrombectomy device and a distal portion of the support wire, wherein the support wire can be positioned in each of the slits of the first ring-shaped portion and the second ring-shaped portion.

[0012] According to one aspect, the slit may have an inclined surface whose facing cross-section is in contact with the surface of the support wire.

[0013] According to one aspect, the minimum width of the slit can be formed to be smaller than the maximum length of the cross-section of the support wire.

[0014] According to one aspect, the proximal portion of the thrombectomy device can be coupled to be caught between the first ring-shaped portion and the second ring-shaped portion.

[0015] According to one aspect, the proximal portion of the thrombectomy device may have a T-shaped tail portion that fits between the first ring-shaped portion and the second ring-shaped portion.

[0016] According to one aspect, the transverse length of the T-shaped tail portion, which is perpendicular to the longitudinal direction of the proximal portion of the thrombus remover, may be greater than the inner diameter of the semi-cylindrical portion of the clasp, the first ring-shaped portion, and the second ring-shaped portion, and less than or equal to the outer diameter.

[0017] According to one aspect, the distal end of the support wire may have a step portion having a maximum cross-sectional length greater than the maximum cross-sectional length of the support wire.

[0018] According to one aspect, the step portion may be tapered in a direction toward the proximal portion of the support wire.

[0019] According to one aspect, the support wire can be placed in the slit while covering the proximal portion of the thrombectomy device disposed between the first ring-shaped portion and the second ring-shaped portion.

[0020] According to one aspect, the locking member may further include a coil wound around the support wire to support the locking member.

[0021] According to one aspect, the clasp may be arranged such that the first end is in contact with the step portion of the support wire and the second end is in contact with the coil and fixed thereto.

[0022] According to one aspect, the locking member may further include soldering applied to at least a portion of the coil, the distal portion of the support wire, the proximal portion of the thrombectomy device, and at least a portion of the clasp to prevent separation of the distal portion of the support wire, the proximal portion of the thrombectomy device, the coil, and the clasp.

[0023] According to one aspect, the soldering applied to the distal portion of the support wire and the proximal portion of the thrombectomy device can be wrapped by a biocompatible adhesive at the step portion of the support wire.

[0024] According to one aspect, the adhesive may be tapered in a direction toward the thrombectomy device.

[0025] According to one embodiment of the present invention for achieving the above-described purpose, a thrombectomy device may include a mechanical thrombectomy device, comprising: a support wire; a clot arrestor having an expandable frame and connected to the support wire; and a locking member configured to couple the support wire and the clot arrestor.

[0026] According to one aspect, the locking portion may include: a step portion formed at a distal end of the support wire; a tail portion formed at a proximal frame end of the expandable frame to be coupled with the step portion; and a locking mechanism that secures the support wire on which the step portion is formed and the proximal frame end on which the tail portion is formed.

[0027] According to one aspect, the support wire and the step portion are tapered and can be made of nitinol.

[0028] According to one aspect, the step portion may be formed in a cylindrical shape having a diameter larger than the diameter of the support wire, with one side of the cylindrical shape having a flat cross-section, so as to be formed in close contact with at least a portion of the tail portion and the proximal frame end portion.

[0029] According to one aspect, the step portion may have a catch surface formed so that at least a portion of the tail portion catches on the connection portion with the support wire.

[0030] According to one aspect, the tail portion may have at least one cut out that catches the hook surface.

[0031] According to one aspect, the cut portion may include a dual fin formed to have the same curvature as the curvature of the step portion.

[0032] According to one aspect, the locking mechanism may include a coil wound on the support wire and the proximal frame end while the tail portion is engaged with the engaging surface of the step portion; and soldering applied at least partially on the coil.

[0033] According to one aspect, the tail portion may have hook-shaped branches that are bent so that their ends are joined together.

[0034] According to one aspect, the distal end of the upper limb support wire having the step portion is inserted into a gap between the branches, and the bent ends of the branches can be formed to be caught on the catch surface of the step portion.

[0035] According to one aspect, the locking mechanism may include a coil wound on the support wire and the proximal frame end while the tail portion is engaged with the engaging surface of the step portion; and soldering applied at least partially on the coil.

[0036] According to one aspect, the tail portion may include a plurality of cylindrical ring-shaped portions that receive and support the support wire.

[0037] According to one aspect, the most distal ring-shaped portion among the ring-shaped portions can be formed to be caught on the catch surface of the step portion.

[0038] According to one aspect, the ring-shaped portion has an opening, and at least some of the openings provided in each of the plurality of cylindrical ring-shaped portions can be arranged in different orientations.

[0039] According to one aspect, the locking mechanism may include at least one of compressing the ring-shaped portion so that the support wire is firmly supported by the ring-shaped portion while the support wire is accommodated within the ring-shaped portion so that the ring-shaped portion is caught on the engaging surface of the step portion, and at least partially soldering the ring-shaped portion.

[0040] According to one aspect, the locking portion may include a step portion formed to have a plurality of first through holes at a distal end of the support wire; a tail portion formed to have a plurality of second through holes respectively corresponding to the plurality of first through holes at a proximal frame end of the expandable frame; and a locking mechanism that couples the support wire formed with the step portion and the proximal frame end formed with the tail portion.

[0041] According to one aspect, the support wire and the step portion are tapered and can be made of nitinol.

[0042] According to one aspect, the step portion is formed in a cylindrical shape having a diameter larger than the diameter of the support wire, and both sides of the cylindrical shape have a flat cross-section, and the plurality of first through holes can be formed in the flat cross-section.

[0043] According to one aspect, the tail portion may be arranged such that the plurality of second through holes of the tail portion overlap with the plurality of first through holes of the step portion.

[0044] According to one aspect, the locking mechanism may include a coil wound on the step portion and the tail portion after intersecting and sealing the plurality of overlapping first through holes and second through holes of the step portion and the tail portion.

[0045] According to one aspect, the locking mechanism may further include soldering applied at least partially over the coil.

[0046] According to one aspect, the step portion may have an edge of the flat cross section ground or tapered.

[0047] The disclosed technology may have the following effects. However, this does not mean that a particular embodiment must include all or only the following effects, and thus the scope of the disclosed technology should not be construed as being limited thereby.

[0048] According to the mechanical thrombus removal device according to one embodiment of the present invention described above, by providing a locking part that connects the support wire and the thrombus remover, the bonding strength between the support wire and the thrombus remover is excellent despite increased fatigue due to repeated deformation of the thrombus removal device, so that the risk of the thrombus remover being separated from the support wire during surgery is low, and a safe thrombus removal device can be provided.

[0049] In addition, the mechanical thrombectomy device according to one embodiment of the present invention described above can provide a mechanical thrombectomy device that can maintain flexible characteristics while having sufficient bonding strength even within a complex vascular structure of a patient by providing a high-strength locking mechanism that has flexibility without increasing the radial profile of the connection portion between the support wire and the thrombectomy device.

[0050] FIG. 1 is a plan view of a mechanical thrombus removal device according to one embodiment of the present invention.

[0051] Figure 2 is an enlarged perspective view of a locking part according to one embodiment of the present invention.

[0052] FIG. 3 is a drawing showing a support wire from various angles according to one embodiment of the present invention.

[0053] FIG. 4 is a drawing showing a tail section from various angles according to one embodiment of the present invention.

[0054] FIG. 5 is a drawing for explaining a locking mechanism according to one embodiment of the present invention.

[0055] FIG. 6 is a drawing showing a locking part according to one embodiment of the present invention from various angles.

[0056] FIG. 7 is a drawing showing a tail section from various angles according to one embodiment of the present invention.

[0057] FIG. 8 is a drawing for explaining a locking mechanism according to one embodiment of the present invention.

[0058] FIG. 9 is an exploded view of a locking part according to one embodiment of the present invention.

[0059] FIG. 10 is a drawing showing a tail section from various angles according to one embodiment of the present invention.

[0060] FIG. 11 is a drawing for explaining a locking mechanism according to one embodiment of the present invention.

[0061] Figure 12 is an enlarged view of a locking part according to one embodiment of the present invention.

[0062] FIG. 13 is a drawing showing a step portion from various angles according to one embodiment of the present invention.

[0063] FIG. 14 is a drawing showing a tail section from various angles according to one embodiment of the present invention.

[0064] FIG. 15 is a drawing for explaining a locking mechanism according to one embodiment of the present invention.

[0065] Figure 16 is an enlarged perspective view of a locking part according to one embodiment of the present invention.

[0066] FIG. 17 is a drawing showing a clasp from various angles according to one embodiment of the present invention.

[0067] Fig. 18 is a cross-sectional view of a state in which a clasp and a support wire are combined according to one embodiment of the present invention.

[0068] FIG. 19 is a drawing for explaining the proximal part of a thrombus remover according to one embodiment of the present invention.

[0069] Figure 20 is a diagram showing the connection between the proximal portion and the clasp of a thrombus remover according to one embodiment of the present invention.

[0070] FIG. 21 is a diagram illustrating the combination of a proximal portion, a clasp, and a support wire of a thrombectomy device according to one embodiment of the present invention.

[0071] Figure 22 is a plan view of a locking part according to one embodiment of the present invention.

[0072] Figure 23 is a side view of a locking part according to one embodiment of the present invention.

[0073] The present invention can be modified in various ways and has various embodiments, and specific embodiments are illustrated in the drawings and described in detail.

[0074] However, this is not intended to limit the present invention to a specific embodiment, but should be understood to include all modifications, equivalents, or substitutes included in the spirit and technical scope of the present invention.

[0075] While terms such as "first" and "second" may be used to describe various components, these components should not be limited by these terms. These terms are used solely to distinguish one component from another. For example, without departing from the scope of the present invention, a first component may be referred to as a "second component," and similarly, a second component may also be referred to as a "first component." The term "and / or" includes any combination of multiple related items described herein or any item among multiple related items described herein.

[0076] When a component is referred to as being "connected" or "connected" to another component, it should be understood that it may be directly connected or connected to that other component, but that there may be other components intervening. Conversely, when a component is referred to as being "directly connected" or "connected" to another component, it should be understood that there are no other components intervening.

[0077] The terminology used in this application is only used to describe specific embodiments and is not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly indicates otherwise. In this application, it should be understood that the terms "comprise" or "have" indicate the presence of a feature, number, step, operation, component, part, or combination thereof described in the specification, but do not exclude in advance the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

[0078] Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. Terms defined in commonly used dictionaries should be interpreted as having a meaning consistent with their meaning in the context of the relevant technology, and will not be interpreted in an idealized or overly formal sense unless explicitly defined herein.

[0079] Hereinafter, with reference to the attached drawings, preferred embodiments of the present invention will be described in more detail. In order to facilitate an overall understanding in describing the present invention, identical reference numerals will be used for identical components in the drawings, and redundant descriptions of identical components will be omitted.

[0080]

[0081] As previously discussed, conventional stent retrievers have been problematic during surgery due to accumulated fatigue caused by repeated deformation as the device is moved through the complex vascular structures of the patient's body, which can cause the connection between the thrombectomy device and the support wire to become disconnected, leading to a potentially hazardous situation during surgery. Furthermore, the connection between the support wire and the thrombectomy device in conventional stent retriever devices lacks sufficient bond strength, preventing optimal transmission of the support wire's traction and propulsion forces to the thrombectomy device during surgery.

[0082] A mechanical thrombus removal device according to one embodiment of the present disclosure is intended to solve the above-described problems, and provides a mechanical thrombus removal device that provides a locking portion that couples a support wire and a thrombus remover to strengthen the bonding force between the thrombus remover and the support wire, and can optimally transmit the traction force and propulsion force of the support wire to the thrombus remover without increasing the radial profile of the connecting portion of the support wire and the thrombus remover.

[0083]

[0084] Below, a mechanical thrombus removal device according to one embodiment is described in more detail with reference to the drawings.

[0085]

[0086] Hereinafter, the term 'thrombus remover' in this description may refer to, for example, a part of a general stent retriever that includes a stent, but is not limited to a conventional stent retriever, and should be understood to include all components necessary to remove coagulated blood within a blood vessel and restore perfusion.

[0087] Additionally, the term 'expandable frame' in this description hereinafter shall be understood to mean a frame that is initially maintained in a compressed state and can be expanded after being moved to an appropriate location, and may be applied in any form known in the art.

[0088] Additionally, the use of relative terms throughout the description of the invention herein may indicate relative positions or directions. For example, "distal" may indicate a first direction along the longitudinal axis of the support wire or thrombectomy device. Similarly, "proximal" may indicate a second direction opposite to the first direction. However, these terms are provided to establish relative references and are not intended to limit the use or orientation of the mechanical thrombectomy device to any particular configuration described in the various embodiments below.

[0089]

[0090] FIG. 1 is a plan view of a mechanical thrombus removal device (1) according to one embodiment of the present invention. As illustrated in FIG. 1, the mechanical thrombus removal device (1) according to one embodiment may include, for example, a support wire (10), a thrombus remover (20), and a locking member (30).

[0091] A mechanical thrombectomy device (1) is an endovascular tool that can be used, for example, to treat acute ischemic stroke. The mechanical thrombectomy device (1) includes a proximal control region that allows an operator to advance, withdraw, and rotate a distal working region of the device. More specifically, the mechanical thrombectomy device (1) includes a support wire (10) that an operator can push to advance the distal working region, pull to withdraw the distal working region, or rotate to rotate the distal working region. In one embodiment, the support wire (10) can be a flexible elongated wire formed of a resilient material, such as stainless steel or a superelastic nickel titanium alloy, for example, nitinol.

[0092] A mechanical thrombectomy device (1) may include a thrombectomy device (20) that can be advanced through a microcatheter and deployed from the microcatheter into a target tissue. When deployed within the target tissue, the thrombectomy device (20) may capture, entrap, bind, or mechanically integrate with the thrombus. The bound thrombus may be retrieved from the patient by traction on the thrombectomy device (20) and a support wire (10) to retrieve the thrombus from the vascular structure.

[0093] The clot remover (20) can be sized and shaped to provide respective degrees of clot binding, clot capture, flexibility, or any other performance characteristic. The clot remover (20) is connected distally to the support wire (10) and can include an expandable frame (100). The expandable frame (100) is a generally elongated cylindrical frame structure capable of capturing and confining a clot within the interior of the cylindrical shape, and has flexibility, shape memory, and contraction functions, and can be made of a shape memory alloy material including, but not limited to, a nickel titanium alloy, in one aspect. The size and shape of each cell of the expandable frame (100) can be determined according to the performance characteristics of the clot remover as described above. The thrombus remover (20) can be formed by laser-cutting a cylindrical tube into a three-dimensional expandable structure, or by mechanical processing, chemical processing, electromechanical processing, electrodischarge processing, and various other methods known in the art, and the expandable frame (100) of the thrombus remover (20) can have, for example, a generally circular cross-sectional profile.

[0094] Although not shown in the drawing, the expandable frame (100) may be equipped with a plurality of radiopaque markers. The radiopaque markers may enhance device visibility and provide a cue for the operator to locate a clot relative to the thrombectomy device. The radiopaque markers may include radiopaque markers mounted in a variety of ways, including radiopaque bands, wire coils, plating, welding, coating, etc., which are conventional in the art. Alternatively, the radiopaque material may be plated onto the expandable frame (100). Alternatively, the radiopaque markers may be formed as bands that are crimped onto the expandable frame (100). In one aspect, the radiopaque markers may include coils formed of radiopaque wire, which may be wound or wrapped around the expandable frame (100). In one aspect, the radiopaque markers may have an atraumatic surface that does not damage the vessel wall during use.

[0095] The locking member (30) is configured to couple the support wire (10) and the thrombectomy device (20). The locking member (30) can directly couple the proximal frame end (110) of the expandable frame (100) of the thrombectomy device (20) and the distal end of the support wire (10) by various locking mechanisms. The locking member (30) should be able to provide sufficient flexibility and joint strength to allow the mechanical thrombectomy device (1) to be naturally transmitted in the tortuous vascular structure when used in the body of a patient.

[0096]

[0097] Hereinafter, a locking part (30) according to an embodiment of the present invention will be described in detail with reference to FIGS. 2 to 5. FIG. 2 is an enlarged perspective view of a locking part (30) according to an embodiment of the present invention, FIG. 3 is a drawing showing a support wire (10) according to an embodiment of the present invention from various angles, FIG. 4 is a drawing showing a tail part (300) according to an embodiment of the present invention from various angles, and FIG. 5 is a drawing for explaining a locking mechanism (400) according to an embodiment of the present invention.

[0098]

[0099] In the embodiment of FIG. 2, the locking portion (30) may include a step portion (200) formed at a distal end of the support wire (10) and a tail portion (300) formed at a proximal frame end (110) of an expandable frame (100) so as to engage with the step portion (200). The locking portion (30) may also include a locking mechanism (400) that secures the support wire (10) having the step portion (200) formed thereon and the proximal frame end (110) having the tail portion (300) formed thereon.

[0100] The support wire (10) and the step portion (200) can be tapered. First, the support wire (10) can be a wire that tapers continuously or in a stepwise manner from the proximal end to the distal end. For example, the distal end of the support wire (10) that is connected to the step portion (200) can have a smaller diameter than the proximal end of the support wire (10), so that the support wire (10) can have a stiffness profile that decreases in the distal direction. In addition, the step portion (200) formed at the distal end of the support wire (10) can have a larger diameter than the diameter of the support wire (10), but can also taper continuously or in a stepwise manner from the proximal end to the distal end, so that the profile can remain compact in the radial direction even after the support wire (10) and the tail portion (300) are fixed by the locking mechanism (400). These support wires (10) and step portions (200) can be made of an elastic material, such as stainless steel or a superelastic nickel titanium alloy having flexibility, shape memory and shrinkage capabilities, for example, nitinol, as described above with respect to FIG. 1, in one embodiment.

[0101] More specifically, referring to FIG. 3, the step portion (200) may be a cylindrical shape having a diameter larger than the diameter of the support wire (10). By forming the diameter of the step portion (200) larger than the diameter of the support wire (10), the tail portion (300) and the locking mechanism (400) are caught by the cross-sectional area of ​​the step created by the diameter difference, so that the support wire (10) and the tail portion (300) can be more reliably coupled. The step portion (200) may be formed so that one side of the cylindrical shape has a flat cross-section (210). Due to this flat cross-section (210), when the locking portion (30) is engaged, the tail portion (300) of the thrombectomy device (20) and at least a portion of the proximal frame end (110) and the step portion (200) can be brought into close contact with each other, and the overall radial profile of the locking portion (30) can also be maintained compactly. Referring to the side view of the support wire (10) illustrated in FIG. 3, the step portion (200) can have a catch surface (220) at the junction with the support wire (10). The catch surface (220) indicates the end surface of the step portion (200) excluding the diametric portion of the support wire (10) at the end connected to the support wire (10), and can be formed so that at least a portion of the tail portion (300) is caught by the catch surface (220) when the locking portion (30) is engaged.

[0102] Referring to FIGS. 4 and 5, the tail portion (300) may have at least one cut out (310) that is engaged with the engaging surface (220). The cut out (310) may be formed in a shape in which the tail portion (300) is at least partially cut out along the longitudinal length of the tail portion (300). In one aspect, the cut outs (310) may be formed symmetrically on both sides of the tail portion (300), so that at least two cut outs (310) are formed. Due to the cut out portions of the cut outs (310), double fins may be formed at both ends of the cut outs (310) in the longitudinal direction of the tail portion (300). These double pins (311) can be formed to have the same curvature as the curvature of the step portion (200) so that they can be in close contact with the engaging surface (220) of the step portion (200). In one aspect, the double pins (311) can also be formed symmetrically on both sides of the tail portion (300) so that at least two double pins (311) are formed, and can have a wider cross-sectional area than the cut portion (310).

[0103] Referring to FIG. 5, a locking mechanism (400) according to one embodiment of the present invention will be described. The step portion (200) and the tail portion (300), which are formed as described in FIGS. 2 to 4, can be coupled to each other so as to be in close contact with each other as shown in FIG. 5. More specifically, the locking mechanism (400) can include a coil (410) that is firmly wound around the support wire (10) and the proximal frame end (110) of the tail portion (300) in a state where the double pin (311) of the tail portion (300) is caught on the catch surface (220) of the step portion (200). Although not illustrated in detail in FIG. 5, in one aspect, when the coil (410) is wound around the support wire (10) and the tail portion (300), the coil (410) can be wound more firmly with a smaller diameter at the cut portion (310) of the tail portion (300) than at other portions due to the small cross-sectional area of ​​the cut portion (310). Accordingly, the tail portion (300) can be fixed without sliding toward the proximal portion of the support wire (10) while in close contact with the support wire (10). More specifically, the double pin (311) of the tail portion (300) with a wider cross-sectional area catches on the coil (410) with a smaller diameter at the cut portion (310), thereby preventing the tail portion (300) from moving from the step portion (200) toward the proximal portion of the support wire (10). In one aspect, one end of the coil (410) can be wound to catch on the catch surface (220) of the step portion (200), which can also prevent separation of the coil (410). In one aspect, the coil (410) can be formed of stainless steel, platinum-iridium, or other radiopaque metal or material visible under fluoroscopy to act as a radiopaque marker.

[0104] In one aspect, the locking mechanism (400) may also include soldering (420) applied at least partially on the coil (410). As described above, the soldering (420) may be applied to at least a portion of the coil (410) while the coil (410) is wound on the proximal frame end (110) of the tail portion (300) and the support wire (10). The soldering (420) may be formed of an alloy material generally including lead, tin, or silver, and may also be formed of a material including a radiopaque material in one aspect to act as a radiopaque marker. The soldering (420) may flow into a gap between the support wire (10) and the coil (410) wound on the proximal frame end (110) of the tail portion (300) to further strengthen the bond between the support wire (10), the tail portion (300), and the coil (410). The diameter and length of the soldering (420) can be determined differently depending on the bonding strength and flexibility required for the mechanical thrombus removal device (1).

[0105]

[0106] FIG. 6 is a drawing showing a locking part (30) according to an embodiment of the present invention from various angles, FIG. 7 is a drawing showing a tail part (300) according to an embodiment of the present invention from various angles, and FIG. 8 is a drawing for explaining a locking mechanism (400) according to an embodiment of the present invention. Hereinafter, another locking structure according to an embodiment of the present invention will be described with reference to FIGS. 6 to 8. The detailed configuration of the support wire (10) and the step part (200) will not be described again since the same characteristics as described above can be applied.

[0107]

[0108] Referring to FIG. 6, one embodiment of the present invention may include a locking portion (30) formed at a distal end of a support wire (10), similar to the embodiments illustrated in FIGS. 2 to 5, and a tail portion (300) formed at a proximal frame end (110) of an expandable frame (100) so as to be coupled with the step portion (200). The locking portion (30) may also include a locking mechanism (400) that secures the support wire (10) having the step portion (200) formed thereon and the proximal frame end (110) having the tail portion (300) formed thereon. However, according to one aspect, the tail portion (300) may have a hook-shaped end that is bent so as to be joined as one.

[0109] Referring to FIG. 7, the tail portion (300) may have hook-shaped branches (320) that are bent so that their ends (321) are joined into one. The tail portion (300) may have a gap (322) between the branches (320) into which a support wire (10) can be inserted, as shown in FIG. 7. In addition, the tail portion (300) may have a gap (322) between the branches (320) that are bent so as to be joined into one and extend in a straight shape, into which a support wire (10) can be inserted.

[0110] Accordingly, the support wire (10) can be inserted into the gap (322) between the branches (320), as shown in FIG. 8, and at this time, the support wire (10) can be inserted in a direction where the bent end (321) of the branches (320) and the engaging surface (220) of the step portion (200) meet. That is, the end (321) of the tail portion (300) comes into contact with and engages the engaging surface (220) of the step portion (200), whereby a connection between the support wire (10) and the tail portion (300) can be primarily formed. According to one aspect, the branches (320) can be pressed so that the support wire (10) is firmly fixed between the gaps (322) after the support wire (10) is inserted into the gaps (322), in which case the radial profile of the combined support wire (10) and the tail portion (300) can be compacted, and the coupling of the tail portion (300) and the support wire (10) can be further strengthened. Furthermore, in one aspect, the branches (320) can be tapered continuously or stepwise toward the ends (321) so as to be thinner than other parts of the tail portion (300), whereby the radial profile of the locking portion (30) can also be compacted.

[0111] In the embodiment shown in FIG. 8, the locking mechanism (400) may include a coil (410) wound on the support wire (10) and the proximal frame end (110) with the tail portion (300) caught on the engaging surface (220) of the step portion (200), and soldering (420) applied at least partially on the coil (410). Although not illustrated in detail in FIG. 8, the coil (410) can be wound firmly so as to have a smaller diameter step on the support wire (10) from which the branches (320) do not extend compared to the portion from which the branches (320) extend when wound on the support wire (10) and the tail portion (300), and accordingly, due to the smaller diameter of the coil (410), the tail portion (300) can be fixed without sliding toward the proximal portion of the support wire (10) while in contact with the support wire (10). That is, the phenomenon in which the branches (320) of the tail portion (300) are caught on the coil (410) having a smaller diameter and the tail portion (300) moves from the step portion (200) toward the proximal portion of the support wire (10) can be prevented, and thus the coupling between the support wire (10) and the tail portion (300) can be further strengthened. These branches (320) can be reinforced several times in bond on the support wire (10) by the engaging surface (220) of the step portion (200), the smaller diameter portion of the coil (410), and the pressurization of the branches (320) as described above. In one aspect, the coil (410) can be formed of stainless steel, platinum-iridium, or other radiopaque metal or material visible under fluoroscopy to act as a radiopaque marker.

[0112] In one aspect, the locking mechanism (400) may also include soldering (420) applied at least partially on the coil (410). As described above, the soldering (420) may be applied to at least a portion of the coil (410) while the coil (410) is wound on the support wire (10) and the proximal frame end (110). The soldering (420) may be formed of an alloy material generally including lead, tin, or silver, and may be formed of a material including a radiopaque material in one aspect to act as a radiopaque marker. The soldering (420) may flow into a gap between the support wire (10) and the coil (410) wound on the proximal frame end (110) of the tail portion (300) to further strengthen the bond between the support wire (10), the tail portion (300), and the coil (410). The diameter and length of the soldering (420) can be determined differently depending on the bonding strength and flexibility required for the mechanical thrombus removal device (1).

[0113]

[0114] FIG. 9 is an exploded view of a locking portion (30) according to one embodiment of the present invention, FIG. 10 is a view illustrating a tail portion (300) according to one embodiment of the present invention from various angles, and FIG. 11 is a view for explaining a locking mechanism (400) according to one embodiment of the present invention. Hereinafter, another locking structure according to one embodiment of the present invention will be described with reference to FIGS. 9 to 11. The detailed configuration of the support wire (10) and the step portion (200) will not be described again since the same characteristics as described above can be applied.

[0115]

[0116] One embodiment of the present invention illustrated in FIGS. 9 to 11 may, like the previously described embodiment, include a locking portion (30) formed at a step portion (200) at a distal end of a support wire (10), and a tail portion (300) formed at a proximal frame end (110) of an expandable frame (100) so as to be coupled with the step portion (200). The locking portion (30) may also include a locking mechanism (400) that secures the support wire (10) having the step portion (200) formed thereon and the proximal frame end (110) having the tail portion (300) formed thereon. However, according to one aspect, the tail portion (300) may include a plurality of cylindrical ring-shaped portions (330) that receive and support the support wire (10).

[0117] As illustrated in FIGS. 9 to 11, the ring-shaped portion (330) has a ring shape of a size capable of accommodating the support wire (10), and the most distal ring-shaped portion (330) among the ring-shaped portions (330) may be formed to be caught on the catch surface (220) of the step portion (200) as illustrated in FIG. 11. In addition, the ring-shaped portion (330) may have an opening portion (331), and at least some of the opening portions (331) provided in each of the plurality of cylindrical ring-shaped portions (330) may be arranged in different orientations. For example, although the opening portions (331) are illustrated as having an intersection-like orientation in FIGS. 9 to 11, the opening portions (331) may be arranged in all different directions. Due to the different orientations of these openings (331), when the device is used in various vascular structures, the support wire (10) can receive an overall even support force without being dislodged through the openings (331).

[0118] In the embodiment illustrated in FIG. 11, the locking mechanism (400) may include at least one of compressing the ring-shaped portion (330) so that the support wire (10) is firmly supported by the ring-shaped portion (330) while the ring-shaped portion (330) is accommodated within the ring-shaped portion (330) so that the ring-shaped portion (330) catches the engaging surface (220) of the step portion (200), and at least partially soldering (420) the ring-shaped portion (330). In one aspect, the ring-shaped portion (330) may be compressed on the support wire (10) to a diameter equal to the diameter of the step portion (200) so that the ring-shaped portion (330) firmly clamps the support wire (10). Additionally, the bonding between the support wire (10) and the tail portion (300) may be further strengthened by at least partially applying soldering (420) on the compression-processed ring-shaped portion (330). The soldering (420) may be formed of an alloy material generally including lead, tin, or silver, and may be formed of a material including a radiopaque material on one side to act as a radiopaque marker. The soldering (420) may flow between the ring-shaped portions (330) and the opening (331) to further strengthen the bonding between the support wire (10) and the ring-shaped portion (330) of the tail portion (300). The diameter and length of the soldering (420) may be determined differently depending on the bonding strength and flexibility required for the mechanical thrombus removal device (1).

[0119]

[0120] FIG. 12 is an enlarged view of a locking portion (30) according to one embodiment of the present invention, FIG. 13 is a view showing a step portion (200) according to one embodiment of the present invention from various angles, FIG. 14 is a view showing a tail portion (300) according to one embodiment of the present invention from various angles, and FIG. 15 is a view for explaining a locking mechanism (400) according to one embodiment of the present invention. Hereinafter, another locking portion according to one embodiment of the present invention will be described with reference to FIGS. 12 to 15.

[0121]

[0122] One embodiment of the present invention illustrated in FIGS. 12 to 15 may, like the previously described embodiments, include a locking portion (30) formed at a step portion (200) at a distal end of a support wire (10), and a tail portion (300) formed at a proximal frame end (110) of an expandable frame (100) so as to be coupled with the step portion (200). The locking portion (30) may also include a locking mechanism (400) that couples the support wire (10) formed with the step portion (200) and the proximal frame end (110) formed with the tail portion (300). However, according to one aspect, the locking portion (30) may include a step portion (200) formed to have a plurality of first through holes (211) at the distal end of the support wire (10) and a tail portion (300) formed to have a plurality of second through holes (340) corresponding to the plurality of first through holes (211) at the proximal frame end (110) of the expandable frame (100). As described above, the support wire (10) and the step portion (200) may, in one embodiment, be made of an elastic material such as stainless steel or a superelastic nickel titanium alloy having flexibility, shape memory and contraction functions, for example, nitinol.

[0123] Referring to FIG. 13, the step portion (200) may be formed in a cylindrical shape having a diameter larger than the diameter of the support wire (10), and may be formed such that both sides of the cylindrical shape have flat cross sections (210). In one aspect, the flat cross sections (210) on both sides may be spaced apart from each other by a distance equal to the diameter of the support wire (10), so that the heights of the step portion (200) and the support wire (10) may be the same when the support wire (10) is viewed from the side, as illustrated in FIG. 12. A plurality of first through holes (211) may be formed in the flat cross section (210), and by forming the diameter of the step portion (200) larger than that of the support wire (10), the strength of the step portion (200) may be maintained despite the formation of a plurality of first through holes (211). Additionally, the flat cross section (210) of the step portion (200) has edges ground or tapered so that a more compact radial profile and excellent bonding properties can be obtained when forming a locking mechanism later.

[0124] Referring to FIG. 14, the tail portion (300) also has a flat cross-section so as to be in contact with the step portion (200), and may have substantially the same length and width as the flat cross-section (210) of the ground or tapered step portion (200). In one aspect, the tail portion (300) may be ground or tapered gradually or stepwise toward the proximal portion. A plurality of second through holes (340) may be formed in the flat cross-section of the tail portion (300) to correspond to the plurality of first through holes (211) of the step portion (200), respectively. These first through holes (211) and second through holes (340) can be arranged to overlap each other, and the size of the first through hole (211) and second through hole (340) can have a diameter that can accommodate a locking mechanism, for example, a coil can pass through.

[0125] Referring to FIG. 15, the locking mechanism (400) may include a coil (410) that joins, for example, seals, the step portion (200) and the tail portion (300). The coil (410) may be formed to first intersect and seal the plurality of overlapping first through-holes (211) and second through-holes (340) of the step portion (200) and the tail portion (300) with the flat cross-sections of the step portion (200) and the tail portion (300) facing each other so that the corresponding plurality of through-holes (211 and 340) are aligned with each other. In one aspect, these sutures can be formed in the form of a straight line passing through the through holes (211, 340) one after the other from one end of the through holes (211, 340) to the other end of the flat cross-section, but the shape of the suture can vary depending on the desired stiffness profile or strength between the support wire (10) and the tail portion (300).

[0126] In addition, the coil (410) can be entirely wound on the step portion (200) and the tail portion (300) after all of the plurality of through holes (211, 340) of the step portion (200) and the tail portion (300) are sealed. This coil (410) can be a coil that is wound by extending integrally with the coil in which the first through hole (211) and the second through hole (340) are sealed. In this case, since the coil (410) is organically intertwined with the support wire (10) and the tail portion (300), the bonding strength is high, and even if any part of the coil (410) is broken, the mechanical thrombus removal device (1) may not be easily damaged. Alternatively, the plurality of through holes (211, 340) may be first sutured with separate wires, and then a separate coil may be wound over the step portion (200) and the tail portion (300) after the through holes (211, 340) are sutured. In one aspect, the coil (410) may be formed of stainless steel, platinum-iridium, or other radiopaque metal or material visible under fluoroscopy to act as a radiopaque marker.

[0127] In one aspect, the locking mechanism (400) may further include soldering (420) applied at least partially on the coil (410). As illustrated in FIG. 15, the soldering (420) may be applied to at least a portion of the coil (410) while the coil (410) is wound on the step portion (200) and the tail portion (300). The soldering (420) may be formed of an alloy material generally including lead, tin, or silver, and may be formed of a material including a radiopaque material in one aspect to act as a radiopaque marker. The soldering (420) may flow into the gap between the coil (410) wound on the support wire (10) and the proximal frame end (110) of the tail portion (300) to further strengthen the bond between the step portion (200), the tail portion (300), and the coil (410). The diameter and length of the soldering (420) can be determined differently depending on the bonding strength and flexibility required for the mechanical thrombus removal device (1).

[0128]

[0129] FIG. 16 is an enlarged perspective view of a locking portion according to an embodiment of the present invention, FIG. 17 is a multi-angle drawing of a clasp according to an embodiment of the present invention, and FIG. 18 is a cross-sectional view of a state in which a clasp and a support wire are coupled according to an embodiment of the present invention. Hereinafter, the configuration of a locking portion according to an embodiment of the present invention will be described in more detail without limitation with reference to FIGS. 16 to 18.

[0130] As illustrated in FIG. 16, a mechanical thrombus removal device according to one aspect of the present invention may include a support wire (10), a thrombus remover (20), and a locking member (30). In one aspect, the support wire (10) may be formed as a structure as illustrated in FIG. 3 or as illustrated in FIG. 16, but is not limited thereto. The support wire (10) may have a stiffness profile that tapers continuously or stepwise from a proximal end to a distal end, thereby decreasing in the distal direction. In addition, the support wire (10) according to one embodiment of the present invention may have a step portion (200) at the distal end. In one aspect, the shape of the step portion (200) is not limited to that shown in FIGS. 3 and 16, and the step portion (200) may be, for example, a cylindrical shape without a flat cross-section (210), or may be formed in a polyhedral shape of any shape other than a cylindrical shape or an irregular shape.

[0131] In one aspect, the step portion (200) may have a maximum cross-sectional length greater than the maximum cross-sectional length of the support wire (10), as illustrated in FIGS. 3 and 16, and a step may be formed by the difference in area resulting from this difference in the maximum cross-sectional lengths of the support wire (10) and the step portion (200). The step portion (200) may have a maximum cross-sectional length greater than the support wire (10), but may taper continuously or in a stepwise manner from the proximal portion to the distal portion, similar to the support wire (10). In one aspect, the step portion (200) may also taper in a direction toward the proximal portion of the support wire (10), for example, as illustrated in FIG. 16. On one side, the surface of the step portion (200) can have an atraumatic surface that does not damage the blood vessel wall when the mechanical thrombectomy device is advanced, withdrawn, or rotated in the operating area by grinding or tapering the edge, thereby improving safety. In addition, the grinding or tapering of the step portion (200) can reduce abrupt changes in the step portion (200) to form a smooth transition portion, thereby preventing abrupt changes in the radial profile of the locking portion (30).

[0132] A thrombus remover (20) according to one embodiment of the present invention has an expandable frame (100) as illustrated in FIG. 1, and can be coupled to a support wire (10) by a locking member (30). In one aspect, the thrombus remover (20) can have a tail shape at a proximal end for coupling with the locking member (30).

[0133] Referring to FIGS. 16 and 17, a locking member (30) according to one embodiment of the present invention may include a clasp (500) configured to couple a support wire (10) and a thrombus remover (20). In one aspect, the clasp (500) may have a body having a semi-cylindrical shape (501), and may have a first ring-shaped portion (510) at a first end of the semi-cylindrical shape (501), and a second ring-shaped portion (520) at a second end. As illustrated in FIG. 17, slits (530) may be formed in each of the first ring-shaped portion (510) and the second ring-shaped portion (520). Referring to FIG. 16, in one aspect, a clasp (500) at least partially surrounds a proximal portion of a thrombectomy device (20) and a distal portion of a support wire (10), wherein the support wire (10) can be positioned in each of a slit (530) of the first ring-shaped portion (510) and the second ring-shaped portion (520). The clasp (500) can be formed of, for example, an alloy including cobalt and chromium, a superelastic nickel titanium alloy including nitinol, or stainless steel.

[0134]

[0135] Fig. 18 is a cross-sectional view showing a state in which a support wire (10) is inserted between slits (530) of a first or second ring-shaped portion (510, 520) of a clasp (500). In one aspect, each of the slits (530) of the first ring-shaped portion (510) and the second ring-shaped portion (520) of the clasp (500) according to an embodiment of the present invention may have an inclined surface (531) whose cross-sections facing each other are in contact with the surface of the support wire (10). In one aspect, the inclined surfaces (531) may be in the form of planes forming an angle with each other or in the form of curved surfaces forming an angle with each other. Due to this inclined surface (531), the width of the slit (530) may be different at a portion of the outer surface of the first or second ring-shaped portion (510, 520) that contacts the support wire (10) and at an inner surface of the first or second ring-shaped portion (510, 520) that contacts the support wire (10). According to one aspect of the present invention, the minimum width (W) of the slit (530) may be formed to be smaller than the maximum length (L) of the cross-section of the support wire (10). By making the minimum width (W) of the slit (530) smaller than the maximum length (L) of the cross-section of the support wire (10), the phenomenon of the support wire (10) being disengaged from the clasp (500) through the slit (530) when the support wire (10) and the locking portion (30) are coupled can be prevented.

[0136]

[0137] FIG. 19 is a drawing for explaining a proximal portion of a thrombus remover according to an embodiment of the present invention, FIG. 20 is a joint diagram of a proximal portion of a thrombus remover and a clasp according to an embodiment of the present invention, FIG. 21 is a joint diagram of a proximal portion, a clasp, and a support wire of a thrombus remover according to an embodiment of the present invention, FIG. 22 is a plan view of a locking portion according to an embodiment of the present invention, and FIG. 23 is a side view of a locking portion according to an embodiment of the present invention.

[0138] First, referring to FIG. 19, a proximal portion of a thrombus remover (20) according to an embodiment of the present invention will be described. The thrombus remover (20) according to an embodiment of the present invention may have a tail shape that can be caught by a locking portion (30) when the proximal portion is coupled with the locking portion (30), as illustrated in FIG. 19. For example, in one aspect, the proximal portion of the thrombus remover (20) may be coupled to be caught by a semi-cylindrical shape (501) portion between a first ring-shaped portion (510) and a second ring-shaped portion (520) of a clasp (500). More specifically, the proximal portion of the thrombus remover (20) may have a T-shaped tail portion (111) that fits between the first ring-shaped portion (510) and the second ring-shaped portion (520) of the clasp (500).

[0139] According to one aspect of the present invention, the transverse length (C) of the T-shaped tail portion (111) perpendicular to the longitudinal direction of the proximal portion of the thrombus remover (20) (illustrated by a dashed line in FIG. 19) may be greater than the inner diameter and less than or equal to the outer diameter of the semi-cylindrical shape (501) portion, the first ring-shaped portion (510), and the second ring-shaped portion (520) of the clasp (500) as illustrated in FIG. 19. More specifically, the T-shaped tail portion (111) according to one embodiment of the present invention may be placed so as to fit on a portion of the clasp (500) corresponding to the thickness of the semi-cylindrical shape (501) portion between the first ring-shaped portion (510) and the second ring-shaped portion (520) of the clasp (500) as illustrated in FIG. 16. This fitting of the T-shaped tail portion (111) is possible because the transverse length (C) of the T-shaped tail portion (111) is greater than the inner diameter of the semi-cylindrical shape (501). In addition, the transverse length (C) of the T-shaped tail portion (111) may be less than or equal to the outer diameter of the semi-cylindrical shape (501), so that the T-shaped tail portion (111) is placed on the portion of the semi-cylindrical shape (501) but does not protrude outside the semi-cylindrical shape (501), thereby preventing the radial profile of the locking portion (30) from increasing. In this regard, in one aspect, the distance between the first ring-shaped portion (510) and the second ring-shaped portion (520) of the clasp (500) may have a gap that matches the longitudinal length of the T-shaped tail portion (111) so that the T-shaped tail portion (111) can be fitted.

[0140]

[0141] Hereinafter, with reference to FIGS. 20 to 23, the combination of the support wire (10), the thrombus remover (20), and the locking member (30) according to one embodiment of the present invention will be described in more detail without limitation.

[0142] In order to couple the support wire (10), the thrombus remover (20), and the locking portion (30) in the mechanical thrombus removal device according to one embodiment of the present invention, first, as illustrated in FIG. 20, the proximal portion of the thrombus remover (20) may be placed on the clasp (500). At this time, the T-shaped tail portion (111) of the proximal portion of the thrombus remover (20) may be placed so as to fit onto the semi-cylindrical shape (501) between the first ring-shaped portion (510) and the second ring-shaped portion (520) of the clasp (500) as described above. Thereafter, as illustrated in FIG. 21 from one side, the support wire (10) may be placed on the proximal portion of the thrombus remover (20). More specifically, the support wire (10) can be placed in the slit (530) of the clasp (500) while covering the proximal portion of the thrombectomy device (20) arranged to fit between, for example, the first ring-shaped portion (510) and the second ring-shaped portion (520). In one aspect, the stepped portion (200) of the support wire (10) can be placed to catch on the outer surface of the first ring-shaped portion (510) of the clasp (500), and the distal portion of the support wire (10) excluding the stepped portion (200) can be placed on at least a portion of the proximal portion of the thrombectomy device (20) and the T-shaped tail portion (111) while passing through each of the slits (530) of the clasp (500). According to one aspect of the present invention, after the T-shaped tail portion (111) and the support wire (10) are arranged on the clasp (500) as described above, the clasp (500) can be tightened so that the first ring-shaped portion (510) and the second ring-shaped portion (520) come into contact with the peripheral surface of the support wire (10) for fixing the support wire (10) and the thrombus remover (20).By arranging and tightening the clasp (500) as described above, not only is the axial movement of the support wire (10) and the thrombus remover (20) prevented, but the support wire (10) and the thrombus remover (20) can be more firmly connected without being separated from the clasp (500).

[0143] Referring to FIG. 22, the locking member (30) according to one embodiment of the present invention may further include a coil (40) wound around the support wire (10) to support the locking member (30). In one aspect, the coil (40) may be placed on the support wire (10) so as to be caught on the outer surface of the second ring-shaped member (520) of the clasp (500), and may be firmly wound around the support wire (10) with a diameter that is, for example, greater than the maximum length of the cross-section of the support wire (10) and less than or equal to the outer diameter of the clasp (500). In one aspect, the coil (40) may be arranged to be at least partially wound on the second ring-shaped portion (520) of the clasp (500), and the first ring-shaped portion (510) and the second ring-shaped portion (520) of the clasp (500) may be tapered or ground to a shape that allows for close engagement with the coil (40) or the step portion (200) to prevent an abrupt increase in the radial profile of the locking portion (30). In one aspect, the coil (40) may be formed of stainless steel, platinum-iridium, or other radiopaque metal or material that is visible to the naked eye to act as a radiopaque marker.

[0144] Referring to FIGS. 22 and 23, in one aspect of the present invention, the clasp (500) may be arranged such that the first end contacts the step portion (200) of the support wire (10) and the second end contacts and is fixed to the coil (40). For example, the first end of the clasp (500) may be arranged such that it contacts the tapered surface of the step portion (200) as shown in the plan view of FIG. 22. More specifically, referring to FIG. 23, a clasp (500) according to an embodiment of the present invention may be arranged so that a T-shaped tail portion (111) of a thrombus remover (20) is fittedly arranged on a semi-cylindrical shape (501) portion, and a support wire (10) is arranged between slits (530) while covering the T-shaped tail portion (111), and a first end of a first ring-shaped portion (510) is fixedly placed in contact with a tapered surface of a step portion (200). In addition, a second end of a clasp (500) according to an embodiment of the present invention may be arranged so as to be fixedly placed in at least partial contact with a coil (40), as illustrated in FIG. 23. As described above, the clasp (500) can act as a locking member that connects the T-shaped tail portion (111) of the thrombus remover (20) and the support wire (10) therein, so that it can be arranged in a form that wraps around the distal portion of the support wire (10) and the proximal portion of the thrombus remover (20), as shown in the side view in FIG. 23, and the first end and the second end are fixed in contact with the step portion (200) and the coil (40), respectively, so that the axial movement of the clasp (500) can be restricted, and thus the axial movement of the support wire (10) and the thrombus remover (20) connected by the clasp (500) can also be prevented.

[0145] According to one aspect of the present invention, the locking member (30) may further include soldering (50) applied to at least a portion of the coil (40), the distal portion of the support wire (10), the proximal portion of the thrombectomy device (20), and at least a portion of the clasp (500) to further prevent separation of the distal portion of the support wire (10), the proximal portion of the thrombectomy device (20), the coil (40), and the clasp (500). The soldering (50) may generally be formed of an alloy material including lead, tin, or silver, and may also be formed of a material including a radiopaque material in one aspect to act as a radiopaque marker. For example, the soldering (50) can be applied to flow into a gap between at least a portion of the coil (40) wound on the support wire (10) and wrap around the distal portion of the support wire (10), the proximal portion of the thrombectomy device (20), and at least a portion of the clasp (500), thereby further strengthening the bond therebetween. In addition, the thickness, diameter, width, and length of the soldering (50) can be determined according to the bonding strength and flexibility characteristics required for the mechanical thrombectomy device (1).

[0146] Referring to FIGS. 22 and 23, in one aspect, the soldering (50) applied to the distal portion of the support wire (10) and the proximal portion of the thrombectomy device (20) can be wrapped by a biocompatible adhesive (60) at the step portion (200) of the support wire (10). The adhesive (60) can make the step portion (200) of the support wire (10) and the proximal portion of the thrombectomy device (20) more firmly attached to each other, and can smoothly finish the end of the soldering (50). In one aspect, the biocompatible adhesive (60) can be tapered in the direction toward the thrombectomy device (20). On one side, the adhesive (60) can be tapered to sufficiently wrap the end of the soldering (50) and form a smooth curve, and this tapering can smooth the step (200) of the support wire (10), thereby providing an atraumatic surface that can reduce frictional force when the mechanical thrombectomy device (1) moves within the blood vessel and prevent damage to the blood vessel wall.

[0147] Due to the various configurations of the locking portion and locking mechanism of the present invention described above, a mechanical thrombus removal device (1) having a high bonding strength can be provided by strengthening the bonding between the distal end of the support wire (10) and the proximal end of the thrombus remover (20), and a thrombus removal device (1) having a sufficiently high bonding strength of the locking portion (30) between the support wire (10) and the thrombus remover (20) can be provided even when repeatedly deformed while maintaining a compact radial profile of the locking portion (30) that bonds the support wire (10) and the thrombus remover (20).

[0148] Although the invention has been described with reference to the drawings and embodiments, it is not intended that the scope of protection be limited by the drawings or embodiments, and it will be understood that those skilled in the art can make various modifications and changes to the invention without departing from the spirit and scope of the claims set forth below.

[0149] The present invention described above is not limited to the above-described embodiments and the attached drawings, and it will be apparent to a person skilled in the art to which the present invention pertains that various substitutions, modifications, and changes can be made within a scope that does not depart from the technical spirit thereof.

[0150] The combination of the above-described embodiments is not limited to the above-described embodiments, and various combinations may be provided in addition to the above-described embodiments depending on implementation and / or needs.

[0151] The above-described embodiments include examples of various aspects. While not all possible combinations to illustrate the various aspects can be described, those skilled in the art will recognize that other combinations are possible. Accordingly, the present invention is intended to encompass all other alterations, modifications, and variations within the scope of the following claims.

[0152] [Explanation of symbols]

[0153] 1: Mechanical thrombectomy device

[0154] 10: Support wire

[0155] 20: Thrombolytic Device

[0156] 30: Lock

[0157] 40: Coil

[0158] 50: Soldering

[0159] 60: Adhesive

[0160] 100: Expandable frame

[0161] 110: Proximal frame end

[0162] 111: T-shaped tail section

[0163] 200: Step section

[0164] 210: Flat cross section

[0165] 211: The first penetration of multiple

[0166] 220: Stuck surface

[0167] 300: Tail section

[0168] 310: Incision

[0169] 311: Double pin

[0170] 320: Branch

[0171] 321: End

[0172] 322: Niche

[0173] 330: Ring-shaped part

[0174] 331: Opening

[0175] 340: Second penetration hole

[0176] 400: Locking mechanism

[0177] 410: Coil

[0178] 420: Soldering

[0179] 500: Clasp

[0180] 501: Semi-cylindrical shape part

[0181] 510: First ring shape

[0182] 520: Second ring shape

[0183] 530: Slit

[0184] 531: Slope

Claims

1. As a mechanical thrombectomy device, support wire; A clot arrestor having an expandable frame and connected to the support wire; and a locking member configured to couple the support wire and the thrombus remover; The above locking part, A clasp having a first ring-shaped portion at a first end of a semi-cylindrical shape and a second ring-shaped portion at a second end, wherein the first ring-shaped portion and the second ring-shaped portion each have a slit formed therein. Mechanical thrombectomy device.

2. In paragraph 1, The clasp at least partially surrounds the proximal portion of the thrombectomy device and the distal portion of the support wire, The above support wire is placed in each of the slits of the first ring-shaped portion and the second ring-shaped portion, Mechanical thrombectomy device.

3. In paragraph 2, The above slit has an inclined surface whose facing cross-section is in contact with the surface of the support wire. Mechanical thrombectomy device.

4. In paragraph 3, The minimum width of the above slit is formed to be smaller than the maximum length of the cross-section of the above support wire. Mechanical thrombectomy device.

5. In paragraph 2, The proximal portion of the above thrombus remover is coupled to be caught between the first ring-shaped portion and the second ring-shaped portion, Mechanical thrombectomy device.

6. In paragraph 2, The proximal portion of the above thrombus remover has a T-shaped tail portion that fits between the first ring-shaped portion and the second ring-shaped portion. Mechanical thrombectomy device.

7. In paragraph 6, The transverse length of the T-shaped tail portion, which is perpendicular to the longitudinal direction of the proximal portion of the thrombus remover, is greater than the inner diameter of the semi-cylindrical portion of the clasp, the first ring-shaped portion, and the second ring-shaped portion, and is less than or equal to the outer diameter. Mechanical thrombectomy device.

8. In paragraph 5, The distal end of the above support wire is, Having a step portion having a maximum cross-sectional length greater than the maximum cross-sectional length of the above support wire, Mechanical thrombectomy device.

9. In paragraph 8, The above step part is, tapering in the direction toward the proximal portion of the above support wire, Mechanical thrombectomy device.

10. In paragraph 8, The above support wire, A proximal portion of the thrombolytic device disposed between the first ring-shaped portion and the second ring-shaped portion, and disposed in the slit, Mechanical thrombectomy device.

11. In paragraph 8, The above locking part, further comprising a coil wound around the support wire to support the locking portion; Mechanical thrombectomy device.

12. In paragraph 11, The above clasp is, The first end is arranged to be in contact with the step portion of the support wire and the second end is arranged to be in contact with the coil and fixed thereto. Mechanical thrombectomy device.

13. In paragraph 12, The above locking part, Further comprising soldering applied to at least a portion of the coil, the distal portion of the support wire, the proximal portion of the thrombectomy device, and at least a portion of the clasp to prevent separation of the distal portion of the support wire, the proximal portion of the thrombectomy device, the coil, and the clasp; Mechanical thrombectomy device.

14. In paragraph 13, The soldering applied to the distal portion of the support wire and the proximal portion of the thrombectomy device is wrapped by a biocompatible adhesive at the step portion of the support wire. Mechanical thrombectomy device.

15. In paragraph 14, The above adhesive, tapering in the direction toward the above thrombolytic device, Mechanical thrombectomy device.

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