Denture stabilizer remover

Abstract

This denture stabilizer remover comprises a polar base and at least one metal compound, said metal compound being a compound selected from the group consisting of: (1) a salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron and at least one compound selected from the group consisting of inorganic acids, organic acids, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) a hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof. Said denture stabilizer remover is able to sufficiently remove a denture stabilizer on dentures.

Description

denture adhesive remover

[0001] The present invention relates to a denture adhesive remover that removes denture adhesive adhering to the oral cavity or dentures.

[0002] Denture adhesives are sometimes used when fitting dentures into the mouth. Denture adhesives are applied to the surface of the denture base, which is the base of the dentures, to increase adhesion and adhesion to the gums and upper jaw, preventing the dentures from slipping when eating or speaking.

[0003] There are various types of denture adhesives, including cream, powder, and cushion types. Among them, the cream-type "Polygrip®" is the leading denture adhesive, sold in large quantities not only at dental clinics but also at general drugstores. Denture adhesives exert their adhesive properties by absorbing saliva in the oral cavity, improving the retention and stability of dentures. The main adhesive components are water-swellable, water-soluble polymers such as sodium / calcium methoxyethylene maleic anhydride copolymer salt (PVMA salt) and carboxymethylcellulose (CMC). Cream-type denture adhesives, including Polygrip, also contain hydrophobic ointment base components such as liquid paraffin and white petrolatum. The denture adhesive is retained in the oral cavity by balancing the water absorption and viscosity of the water-soluble polymer with the resistance to leaching provided by the hydrophobic ointment base components.

[0004] On the other hand, dentures and denture adhesives are not permanently retained in the oral cavity and must be periodically removed and cleaned. Current denture cleaning methods include mechanical cleaning using a brush or chemical cleaning using detergents. It is desirable that neither cleaning method will scratch or deform the dentures.

[0005] However, it is not easy to completely remove denture adhesive from the mouth or dentures. This is due to the fact that highly adhesive denture adhesive adheres strongly to the mouth and dentures, and the fact that applying too much force to thoroughly remove it can lead to bleeding from the oral mucosa, pain for the patient, and damage or deformation of the dentures, making active cleaning difficult both practically and psychologically. Furthermore, the complex structure of the mouth, including the teeth, dental neck, and unevenness of the dentures, makes removing denture adhesive difficult. Especially in care settings, it is often difficult to obtain the cooperation of denture wearers or to devote time and effort to cleaning, resulting in occasional cases of denture adhesive remaining in the mouth or on dentures.

[0006] Bacteria can grow on the surface of denture adhesive remaining in the mouth or on dentures, forming a biofilm that can lead to denture stomatitis. It has also been suggested that oral bacteria may be involved in diseases such as bacterial endocarditis, aspiration pneumonia, and respiratory tract infections. Since many denture wearers are elderly and often in poor general health, they are more susceptible to these diseases. Therefore, an effective method for removing denture adhesive is needed.

[0007] Several denture adhesive removers are known. For example, Patent Document 1 describes that a denture adhesive remover containing 30 to 60% by weight of a lower alcohol, water, a thickener, and a surfactant can effectively remove denture adhesive and also has a bactericidal effect. However, the remover taught in Patent Document 1 cannot completely remove denture adhesive from dentures even when force is applied after the remover is applied to the dentures and denture adhesive.

[0008] JP 2020-164500 A

[0009] An object of the present invention is to provide a denture adhesive remover that can sufficiently remove denture adhesive adhering to dentures.

[0010] To solve the above problems, the present inventors focused on the chemical properties of denture adhesives. They believed that chemically inhibiting the function of the water-swellable, water-soluble polymer compounds contained in denture adhesives and reducing their adhesiveness would enable effective removal of denture adhesive from dentures. They then discovered that a formulation containing a polar base and a specific metal compound could adequately remove denture adhesive from dentures.

[0011] The present invention was completed based on the above findings and provides the following items [1] to [9]: [1] A denture adhesive remover comprising a polar base and at least one metal compound, wherein the metal compound is a compound selected from the group consisting of: (1) a salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron with at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) a hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof. [2] The denture adhesive remover according to [1], wherein the inorganic acid is a compound selected from the group consisting of hydrochloric acid, carbonic acid, nitric acid, nitrous acid, sulfuric acid, sulfurous acid, thiosulfuric acid, silicic acid, phosphoric acid, and hydrofluoric acid, and the organic acid is a compound selected from the group consisting of lactic acid, acetic acid, citric acid, gluconic acid, and hexacyanoic acid. [3] The denture adhesive remover according to [1] or [2], wherein the polar base is at least one selected from the group consisting of lower alcohols, higher alcohols, polyhydric alcohols, and glycol ethers. [4] The denture adhesive remover according to any of [1] to [3], wherein the concentration of the polar base is 1 to 99% by mass, based on the total amount of the denture adhesive remover. [5] The denture adhesive remover according to any of [1] to [4], wherein the concentration of the metal compound is 0.01 to 97% by mass, based on the total amount of the denture adhesive remover. [6] The denture adhesive remover according to any one of [1] to [5], wherein the content of the metal compound is 0.0005 to 20 parts by mass per part by mass of the polar base. [7] The denture adhesive remover according to any one of [1] to [6], further comprising a surfactant. [8] The denture adhesive remover according to [7], wherein the concentration of the surfactant is 0.01 to 20% by mass, based on the total amount of the denture adhesive remover. [9] The denture adhesive remover according to [7] or [8], wherein the content of the surfactant is 0.01 to 20 parts by mass per part by mass of the metal compound.

[10] The denture adhesive remover according to any one of [1] to [9], further comprising water.

[11] The denture adhesive remover according to

[10] , wherein the concentration of water is 0.001 to 90% by mass based on the total amount of the denture adhesive remover.

[12] The denture adhesive remover according to any one of [1] to

[11] , which is used to remove denture adhesive from dentures or the oral cavity.

[13] Use of a composition comprising a polar base and at least one metal compound, wherein the metal compound is a compound selected from the group consisting of: (1) a salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron with at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) a hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof, as a denture adhesive remover or for producing a denture adhesive remover.

[14] A method for removing a denture adhesive, comprising the step of applying to the denture adhesive an effective amount of a composition comprising a polar base and at least one metal compound, wherein the metal compound is a compound selected from the group consisting of: (1) a salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron with at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) a hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof.

[0012] Conventional denture adhesive removers (hereinafter sometimes abbreviated as "removers") were unable to completely remove denture adhesive stuck to dentures even with strong force. However, the denture adhesive remover of the present invention chemically weakens the adhesion of denture adhesive, allowing it to be removed with less or no force compared to conventional removers. Furthermore, the remover of the present invention acts on denture adhesive, changing its properties to remove it, so it can be removed not only from dentures but also from the oral mucosa. Furthermore, it is suitable for removing denture adhesive stuck to or adhered to the oral mucosa because it can sufficiently remove denture adhesive without containing any irritating ingredients or ingredients that may have adverse effects on the human body. Conventional removers remove denture adhesive stuck to dentures by removing them from the mouth; no removers exist that can remove denture adhesive stuck to the oral cavity. The remover of the present invention also has high commercial value because it can effectively remove denture adhesive stuck to the oral cavity.

[0013] Many denture adhesives adhere strongly to the denture base and oral mucosa because the carboxyl-containing polymer ionizes and becomes negatively charged upon contact with water, resulting in electrostatic interactions with the denture base and oral mucosa. While not limited to this mechanism, it is believed that the polar base of the remover of the present invention inhibits this electrostatic interaction, thereby weakening the adhesion of the denture adhesive to dentures. Also, while not limited to this mechanism, it is believed that the carboxyl-containing polymer contained in many denture adhesives ionizes and becomes negatively charged upon contact with water, thickening due to intra- and intermolecular electrostatic repulsion and steric hindrance. The action of metal ions on this polymer is thought to reduce its viscosity, making it easier for the adhesive to peel off from dentures and the oral cavity.

[0014] Photographs of the inside of the oral cavity before and after wiping off denture adhesive adhering to the oral cavity with the preparation of Example 57. Photographs of the inside of the oral cavity before and after wiping off denture adhesive adhering to the oral cavity with the preparation of Comparative Example 2.

[0015] The present invention is described in detail below. The denture adhesive remover of the present invention comprises a polar base and at least one metal compound, wherein the metal compound is a compound selected from the group consisting of: (1) a salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron with at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) a hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof.

[0016] Polar Base The polar base can be any polar base used in topical compositions, such as lower alcohols (alcohols having 1 to 5 carbon atoms, preferably 2 to 4 carbon atoms), higher alcohols (aliphatic alcohols having 6 to 24 carbon atoms, preferably 12 to 18 carbon atoms), polyhydric alcohols, and glycol ethers. One or more polar bases can be used. The polar base's form at room temperature varies depending on the type and molecular weight, and can be liquid, paste, powder, flake, or other form. The properties of the remover can be adjusted by using a combination of polar bases.

[0017] Examples of lower alcohols include methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, amyl alcohol, etc. Examples of higher alcohols include linear saturated higher alcohols such as hexyl alcohol, heptyl alcohol, capryl alcohol, nonyl alcohol, decyl alcohol, undecanol, lauryl alcohol, myristyl alcohol, cetanol, cetearyl alcohol, stearyl alcohol, arachidyl alcohol, and behenyl alcohol; linear unsaturated higher alcohols such as oleyl alcohol, linoleyl alcohol, and lignoceryl alcohol; and branched saturated higher alcohols such as hexyldecanol, isostearyl alcohol, octyldodecanol, and decyltetradecanol.

[0018] Examples of polyhydric alcohols include propylene glycol, dipropylene glycol, polypropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, isoprene glycol, polyethylene glycol, etc. The polyhydric alcohol may be a polymer such as polypropylene glycol or polyethylene glycol, or a non-polymer, but is preferably a polymer.

[0019] Examples of glycol ethers include ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, and dipropylene glycol monopropyl ether.

[0020] The polar base is preferably a lower alcohol or a polyhydric alcohol, and among these, ethanol, isopropyl alcohol, polypropylene glycol, and polyethylene glycol are preferred.

[0021] The concentration of the polar base can be 1% by weight or more, 5% by weight or more, 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, or 50% by weight or more, based on the total amount of the remover. Within this range, denture adhesive can be effectively removed. Furthermore, the concentration of the polar base can be 99% by weight or less, 98% by weight or less, 97% by weight or less, 96% by weight or less, 95% by weight or less, 93% by weight or less, 90% by weight or less, 80% by weight or less, 70% by weight or less, or 60% by weight or less, based on the total amount of the remover. Within this range, a sufficient amount of other components such as metal compounds can be blended, resulting in a formulation that exhibits high denture adhesive removal effectiveness.

[0022] The concentration of the polar base relative to the total amount of the remover is 1 to 99 mass%, 1 to 98 mass%, 1 to 97 mass%, 1 to 96 mass%, 1 to 95 mass%, 1 to 93 mass%, 1 to 90 mass%, 1 to 80 mass%, 1 to 70 mass%, 1 to 60 mass%; 5 to 99 mass%, 5 to 98 mass%, 5 to 97 mass%, 5 to 96 mass%, 5 to 95 mass%, 5 to 93 mass%, 5 to 90 mass%, 5 to 60 mass%. -80% by mass, 5-70% by mass, 5-60% by mass; 10-99% by mass, 10-98% by mass, 10-97% by mass, 10-96% by mass, 10-95% by mass, 10-93% by mass, 10- 90% by mass, 10-80% by mass, 10-70% by mass, 10-60% by mass; 20-99% by mass, 20-98% by mass, 20-97% by mass, 20-96% by mass, 20-95% by mass, 20 ~93% by mass, 20-90% by mass, 20-80% by mass, 20-70% by mass, 20-60% by mass; 30-99% by mass, 30-98% by mass, 30-97% by mass, 30-96% by mass, 30-95% by mass, 30-93% by mass, 30-90% by mass, 30-80% by mass, 30-70% by mass, 30-60% by mass; 40-99% by mass, 40-98% by mass, 40-97% by mass , 40-96% by mass, 40-95% by mass, 40-93% by mass, 40-90% by mass, 40-80% by mass, 40-70% by mass, 40-60% by mass; 50-99% by mass, 50-98% by mass %, 50-97% by mass, 50-96% by mass, 50-95% by mass, 50-93% by mass, 50-90% by mass, 50-80% by mass, 50-70% by mass, and 50-60% by mass.

[0023] When the remover contains a polyhydric alcohol, its concentration can be 1% by weight or more, 5% by weight or more, 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, or 50% by weight or more. Within this range, denture adhesive can be effectively removed. Furthermore, the concentration of the polyhydric alcohol can be 99% by weight or less, 98% by weight or less, 97% by weight or less, 96% by weight or less, 95% by weight or less, 93% by weight or less, 90% by weight or less, 80% by weight or less, 70% by weight or less, or 60% by weight or less, based on the total amount of the remover. Within this range, a sufficient amount of other components such as metal compounds can be blended, resulting in a formulation that exhibits high denture adhesive removal effectiveness.

[0024] The concentration of the polyhydric alcohol relative to the total amount of the remover is 1 to 99 mass%, 1 to 98 mass%, 1 to 97 mass%, 1 to 96 mass%, 1 to 95 mass%, 1 to 93 mass%, 1 to 90 mass%, 1 to 80 mass%, 1 to 70 mass%, 1 to 60 mass%; 5 to 99 mass%, 5 to 98 mass%, 5 to 97 mass%, 5 to 96 mass%, 5 to 95 mass%, 5 to 93 mass%, 5 to 90 mass% , 5-80% by mass, 5-70% by mass, 5-60% by mass; 10-99% by mass, 10-98% by mass, 10-97% by mass, 10-96% by mass, 10-95% by mass, 10-93% by mass, 1 0 to 90 mass%, 10 to 80 mass%, 10 to 70 mass%, 10 to 60 mass%; 20 to 99 mass%, 20 to 98 mass%, 20 to 97 mass%, 20 to 96 mass%, 20 to 95 mass%, 20-93 mass%, 20-90 mass%, 20-80 mass%, 20-70 mass%, 20-60 mass%; 30-99 mass%, 30-98 mass%, 30-97 mass%, 30-96 mass% , 30-95% by mass, 30-93% by mass, 30-90% by mass, 30-80% by mass, 30-70% by mass, 30-60% by mass; 40-99% by mass, 40-98% by mass, 40-97% by mass %, 40-96% by mass, 40-95% by mass, 40-93% by mass, 40-90% by mass, 40-80% by mass, 40-70% by mass, 40-60% by mass; 50-99% by mass, 50-98 quality %, 50-97% by mass, 50-96% by mass, 50-95% by mass, 50-93% by mass, 50-90% by mass, 50-80% by mass, 50-70% by mass, and 50-60% by mass.

[0025] When the remover contains a lower alcohol, its concentration can be 5% by mass or more, 10% by mass or more, 20% by mass or more, 25% by mass or more, 30% by mass or more, 40% by mass or more, or 50% by mass or more. Within this range, denture adhesive can be effectively removed. Furthermore, the concentration of the lower alcohol can be 40% by mass or less, 35% by mass or less, 30% by mass or less, 20% by mass or less, 15% by mass or less, 10% by mass or less, or 5% by mass or less, based on the total amount of the remover. Within this range, a sufficient amount of other metal compounds can be blended, resulting in a formulation that exhibits a high denture adhesive removal effect. In particular, a concentration of 10% by mass or less reduces irritation to the oral mucosa, making it even more suitable for use as an oral denture adhesive remover.

[0026] The concentration of the lower alcohol relative to the total amount of the remover may be 5 to 40 mass%, 5 to 35 mass%, 5 to 30 mass%, 5 to 20 mass%, 5 to 15 mass%, 5 to 10 mass%; 10 to 40 mass%, 10 to 35 mass%, 10 to 30 mass%, 10 to 20 mass%, 10 to 15 mass%; 20 to 40 mass%, 20 to 35 mass%, 20 to 30 mass%; 25 to 40 mass%, 25 to 35 mass%, 25 to 30 mass%; 30 to 40 mass%, 30 to 35 mass%.

[0027] Metal Compounds Examples of metal compounds include salts of at least one metal selected from sodium, potassium, calcium, magnesium, aluminum, zinc, and iron with at least one selected from inorganic acids, organic acids, and ammonia, or hydrates thereof. Examples of inorganic acids include hydrochloric acid, carbonic acid, phosphoric acid, nitric acid, nitrous acid, sulfuric acid, sulfurous acid, thiosulfuric acid, silicic acid, and hydrofluoric acid. Phosphates can be excluded from inorganic acid salts, and calcium phosphate can be excluded in particular. Examples of organic acids include lactic acid, acetic acid, citric acid, hexacyanoic acid, and gluconic acid. Stearates can be excluded from organic acid salts, and calcium stearate can be excluded in particular. Examples of metal compounds include oxides of at least one metal selected from sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or hydrates thereof. Examples of oxides include magnesium oxide. Examples of metal compounds include hydroxides of at least one metal selected from sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or hydrates thereof. The metal compound may contain two or more types of metals and may also contain two or more types of counter ions of the metal ions, such as salts of the above metals with organic or inorganic acids and ammonia.

[0028] Examples of metal compounds include sodium chloride, sodium carbonate, sodium bicarbonate, sodium sulfate (e.g., anhydrous sodium sulfate), sodium sulfite, sodium thiosulfate, sodium acetate, sodium nitrite, sodium fluoride, sodium lactate, sodium acetate, sodium citrate, sodium gluconate, and sodium hydroxide; potassium chloride, potassium fluoride, potassium carbonate, potassium bicarbonate, potassium phosphate, potassium lactate, potassium acetate, potassium citrate, potassium gluconate, and potassium aluminum sulfate; calcium sulfate, calcium nitrate, calcium bicarbonate, calcium chloride, calcium oxide, calcium lactate, calcium citrate, and calcium acetate; magnesium chloride, magnesium sulfate, magnesium nitrate, magnesium citrate, and magnesium acetate; aluminum chloride, aluminum sulfate, aluminum phosphate, aluminum ammonium sulfate, aluminum nitrate, aluminum oxide, and aluminum lactate; zinc chloride, zinc fluoride, zinc sulfate, zinc nitrate, and zinc gluconate; iron chloride, iron sulfate, ammonium iron sulfate, and potassium iron hexacyanoate (e.g., potassium iron (III) hexacyanoate); and hydrates thereof. Among these, preferred metal compounds include sodium carbonate, sodium chloride, sodium sulfate (e.g., anhydrous sodium sulfate), sodium sulfite, sodium thiosulfate, sodium hydroxide; potassium fluoride, potassium hexacyanoferrate (III), potassium hydroxide, potassium aluminum sulfate, potassium acetate; calcium acetate, calcium chloride, calcium lactate, calcium oxide; magnesium chloride, magnesium nitrate, magnesium sulfate, magnesium acetate; aluminum lactate, aluminum sulfate, aluminum phosphate, ammonium aluminum sulfate, aluminum oxide; zinc fluoride; zinc chloride, zinc fluoride, zinc nitrate; iron chloride, iron sulfate, ammonium iron sulfate, potassium iron hexacyanoate (e.g., potassium iron hexacyanoate (III)); and hydrates thereof, which provide particularly excellent removal effects.

[0029] For example, if a compound that does not irritate the oral mucosa or has an unpleasant taste is selected from these compounds, it will be more suitable as an agent for removing denture adhesive from the oral cavity.

[0030] One or more metal compounds can be used. The metal compound used in the present invention can be a compound that generates metal ions (particularly, a certain amount of metal ions) in the remover or in the remover mixed with water during use.

[0031] The concentration of the metal compound in the remover can be 0.01% by mass or more, 0.05% by mass or more, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, 5% by mass or more, 10% by mass or more, or 20% by mass or more, based on the total amount of the remover. Within this range, denture adhesive can be effectively removed. Furthermore, the concentration of the metal compound in the remover can be 97% by mass or less, 95% by mass or less, 90% by mass or less, 80% by mass or less, 70% by mass or less, 60% by mass or less, 50% by mass or less, 40% by mass or less, or 30% by mass or less, based on the total amount of the remover. Within this range, a sufficient amount of a polar base or the like can be blended, resulting in a formulation that exhibits high denture adhesive removal effectiveness.

[0032] The concentration of the metal compound relative to the total amount of the removing agent is 0.01 to 97% by mass, 0.01 to 95% by mass, 0.01 to 90% by mass, 0.01 to 80% by mass, 0.01 to 70% by mass, 0.01 to 60% by mass, 0.01 to 50% by mass, 0.01 to 40% by mass, 0.01 to 30% by mass; 0.05 to 97% by mass, 0.05 to 95% by mass, 0.05 to 90% by mass, 0.05 to 80% by mass, 0.05 to 70% by mass, 0.05 to 60% by mass, 0.05 to 50% by mass, 0.05 to 40% by mass, 0.05 to 30% by mass; 0.1 to 97% by mass, 0.1 to 95% by mass, 0.1 to 90% by mass, 0.1 to 80% by mass, 0.1 to 70% by mass, 0.1 to 60% by mass, 0.1 to 50% by mass, 0.1 to 40% by mass, 0.1 to 30% by mass; 0.5 to 97% by mass, 0.5 to 95% by mass, 0.5 to 90% by mass, 0.5 to 80% by mass, 0.5 to 70% by mass, 0.5 to 60% by mass, 0.5 to 50% by mass, 0.5 to 40% by mass, 0.5 to 30% by mass; 1 to 97% by mass, 1 to 95% by mass, 1 to 90% by mass, 1 to 80% by mass, 1 to 70% by mass, 1 to 60% by mass, 1 to 50% by mass, 1 to 40% by mass, 1 to 30% by mass; 5 to 97% by mass, 5 to 95% by mass, 5 to 90% by mass, 5 to 80% by mass, 5 to 70% by mass, 5 to 60% by mass, 5 to 50% by mass, 5 to 40% by mass, 5 to 30% by mass; 10 to 97% by mass, 10 to 95% by mass, 10 to 90% by mass, 10 to 80% by mass, 10 to 70% by mass, 10 to 60% by mass, 10 to 50% by mass, 10 to 40% by mass, 10 to 30% by mass; 20 to 97% by mass, 20 to 95% by mass, 20 to 90% by mass, 20 to 80% by mass, 20 to 70% by mass, 20 to 60% by mass, 20 to 50% by mass, 20 to 40% by mass, 20 to 30% by mass.

[0033] The content of the metal compound in the remover can be 0.0005 parts by mass or more, 0.001 parts by mass or more, 0.005 parts by mass or more, 0.01 parts by mass or more, 0.05 parts by mass or more, or 0.1 parts by mass or more per part by mass of the polar base. Within these ranges, denture adhesive can be effectively removed. Furthermore, the content of the metal compound in the remover can be 20 parts by mass or less, 10 parts by mass or less, 8 parts by mass or less, 5 parts by mass or less, 3 parts by mass or less, 2 parts by mass or less, 1 part by mass or less, or 0.5 parts by mass or less per part by mass of the polar base. Within these ranges, a sufficient amount of other polar bases can be blended, resulting in a formulation that exhibits high denture adhesive removal effectiveness.

[0034] The ratio of the content of the metal compound to 1 part by mass of the polar base is 0.0005 to 20 parts by mass, 0.0005 to 10 parts by mass, 0.0005 to 8 parts by mass, 0.0005 to 5 parts by mass, 0.0005 to 3 parts by mass, 0.0005 to 2 parts by mass, 0.0005 to 1 part by mass, 0.0005 to 0.5 parts by mass; 0.001 to 20 parts by mass , 0.001 to 10 parts by mass, 0.001 to 8 parts by mass, 0.001 to 5 parts by mass, 0.001 to 3 parts by mass, 0.001 to 2 parts by mass, 0.001 to 1 part by mass, 0. 001-0.5 parts by mass; 0.005-20 parts by mass, 0.005-10 parts by mass, 0.005-8 parts by mass, 0.005-5 parts by mass, 0.005-3 parts by mass, 0.0 05-2 parts by mass, 0.005-1 parts by mass, 0.005-0.5 parts by mass; 0.01-20 parts by mass, 0.01-10 parts by mass, 0.01-8 parts by mass, 0.01-5 Parts by mass, 0.01 to 3 parts by mass, 0.01 to 2 parts by mass, 0.01 to 1 part by mass, 0.01 to 0.5 parts by mass; 0.05 to 20 parts by mass, 0.05 to 10 parts by mass, 0.0 5 to 8 parts by mass, 0.05 to 5 parts by mass, 0.05 to 3 parts by mass, 0.05 to 2 parts by mass, 0.05 to 1 part by mass, 0.05 to 0.5 parts by mass; 0.1 to 20 parts by mass, 0 .1 to 10 parts by weight, 0.1 to 8 parts by weight, 0.1 to 5 parts by weight, 0.1 to 3 parts by weight, 0.1 to 1 part by weight, and 0.1 to 0.5 parts by weight.

[0035] When the metal compound is a hydrate, the concentration and content of the metal compound are those excluding water of hydration.

[0036] Polar bases and metal compounds also fall under the category of "polar bases" and "metal compounds" of the present invention when they are incorporated for purposes other than releasing denture adhesive, such as as additives as described below.

[0037] The denture adhesive remover of the present invention requires the presence of water to be effective, based on its principles. However, the denture adhesive remover of the present invention may or may not contain water. When water is contained, preparation before use is not required and the remover can be applied directly to the oral cavity or dentures, resulting in a formulation with high convenience during use. When water is not contained, preparation before use by adding water is required, but the absence of water allows the weight of the formulation itself to be reduced, resulting in a formulation with high convenience during distribution. When water is contained, the concentration of water can be 0.001% by weight or more, 0.01% by weight or more, 0.1% by weight or more, 1% by weight or more, 5% by weight or more, 10% by weight or more, 20% by weight or more, 30% by weight or more, or 40% by weight or more, based on the total amount of the remover. Within this range, the formulation can fully exert its denture adhesive removal effect without the addition of external water. Furthermore, the water concentration can be 90% by weight or less, 80% by weight or less, 70% by weight or less, 60% by weight or less, or 50% by weight or less, based on the total amount of the remover. Within this range, a sufficient amount of metal compound and polar base can be blended, resulting in a preparation that can fully exhibit the effect of removing denture adhesive.

[0038] The concentration of water relative to the total amount of the remover is 0.001 to 90 mass%, 0.001 to 80 mass%, 0.001 to 70 mass%, 0.001 to 60 mass%, 0.001 to 50 mass%; 0.01 to 90 mass%, 0.01 to 80 mass%, 0.01 to 70 mass%, 0.01 to 60 mass%, 0.01 to 50 mass%; 0.1 to 90 mass%, 0.1 to 80 mass%, 0.1 to 70 mass%, 0.1 to 60 mass%, 0.1 to 50 mass%; 1 to 90 mass%, 1 to 80 mass%, 1 to 70 mass%, 1 to 60 mass%, 1 to 50 mass%; ~90% by mass, 5-80% by mass, 5-70% by mass, 5-60% by mass, 5-50% by mass; 10-90% by mass, 10-80% by mass, 10-70% by mass, 10-60% by mass, 10-50% by mass; 20-90% by mass, 20-80% by mass, 20-70% by mass, 2 0 to 60 mass%, 20 to 50 mass%; 30 to 90 mass%, 30 to 80 mass%, 30 to 70 mass%, 30 to 60 mass%, 30 to 50 mass%; 40 to 90 mass%, 40 to 80 mass%, 40 to 70 mass%, 40 to 60 mass%, 40 to 50 mass%.

[0039] When the denture adhesive remover of the present invention contains water, the water content can be at least 0.001 parts by weight, at least 0.01 parts by weight, at least 0.05 parts by weight, at least 0.1 parts by weight, at least 1 part by weight, at least 5 parts by weight, at least 10 parts by weight, at least 30 parts by weight, at least 50 parts by weight, or at least 80 parts by weight, per part by weight of the polar base. Within these ranges, the formulation will suppress irritation to the oral mucosa caused by the polar base and will exhibit sufficient denture adhesive removal effects. Furthermore, the water content can be no more than 95 parts by weight, no more than 90 parts by weight, no more than 80 parts by weight, no more than 70 parts by weight, no more than 60 parts by weight, no more than 50 parts by weight, no more than 30 parts by weight, no more than 10 parts by weight, no more than 5 parts by weight, or no more than 3 parts by weight, per part by weight of the polar base. Within these ranges, sufficient amounts of metal compound and polar base can be incorporated, resulting in a formulation that can exhibit sufficient denture adhesive removal effects.

[0040] The ratio of the water content to 1 part by mass of the polar base is 0.001 to 95 parts by mass, 0.001 to 90 parts by mass, 0.001 to 80 parts by mass, 0.001 to 70 parts by mass, 0.001 to 60 parts by mass, 0.001 to 50 parts by mass, 0.001 to 30 parts by mass, 0.001 to 10 parts by mass, 0.001 to 5 parts by mass, 0.001 to 3 parts by mass; 0.01 to 95 parts by mass, 0.01 to 90 parts by mass, 0.01 to 80 parts by mass, 0.01 to 70 parts by mass, 0.01 to 60 parts by mass. Parts by weight, 0.01 to 50 parts by weight, 0.01 to 30 parts by weight, 0.01 to 10 parts by weight, 0.01 to 5 parts by weight, 0.01 to 3 parts by weight; 0.05 to 95 parts by weight, 0.05 to 90 parts by weight, 0.05 to 80 parts by weight, 0.05 to 70 parts by weight parts, 0.05 to 60 parts by mass, 0.05 to 50 parts by mass, 0.05 to 30 parts by mass, 0.05 to 10 parts by mass, 0.05 to 5 parts by mass, 0.05 to 3 parts by mass; 0.1 to 95 parts by mass, 0.1 to 90 parts by mass, 0.1 to 80 parts by mass, 0.1 ~70 parts by mass, 0.1 to 60 parts by mass, 0.1 to 50 parts by mass, 0.1 to 30 parts by mass, 0.1 to 10 parts by mass, 0.1 to 5 parts by mass, 0.1 to 3 parts by mass; 1 to 95 parts by mass, 1 to 90 parts by mass, 1 to 80 parts by mass, 1 to 70 parts by mass, 1 ~60 parts by weight, 1 to 50 parts by weight, 1 to 30 parts by weight, 1 to 10 parts by weight, 1 to 5 parts by weight, 1 to 3 parts by weight; 5 to 95 parts by weight, 5 to 90 parts by weight, 5 to 80 parts by weight, 5 to 70 parts by weight, 5 to 60 parts by weight, 5 to 50 parts by weight, 5 to 30 parts by weight Parts by weight, 5 to 10 parts by weight; 10 to 95 parts by weight, 10 to 90 parts by weight, 10 to 80 parts by weight, 10 to 70 parts by weight, 10 to 60 parts by weight, 10 to 50 parts by weight, 10 to 30 parts by weight; 30 to 95 parts by weight, 30 to 90 parts by weight, 30 to 80 parts by weight Parts by weight, 30-70 parts by weight, 30-60 parts by weight, 30-50 parts by weight; 50-95 parts by weight, 50-90 parts by weight, 50-80 parts by weight, 50-70 parts by weight, 50-60 parts by weight; 80-95 parts by weight, 80-90 parts by weight.

[0041] When the remover of the present invention does not contain water, it may be prepared at the time of use so that it contains water at the above concentration or content.

[0042] In addition to the polar base, metal compound, and optionally water, the denture adhesive remover of the present invention may contain additives depending on the formulation, provided that the effects of the present invention are not impaired. Examples of additives include surfactants, pH adjusters, bactericidal components or preservatives, humectants, stabilizers, thickeners, sweeteners, and flavorings. One or more additives may be used.

[0043] Surfactants that can be used include anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, naturally occurring surfactants, and organic solvents that function as solubilizers. The cleansing effect of surfactants can emulsify hydrophobic ointment base components such as liquid paraffin and white petrolatum contained in denture adhesives, further increasing the efficiency of denture adhesive removal.

[0044] Examples of anionic surfactants include higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate; alkyl ether sulfates such as POE-triethanolamine lauryl sulfate and sodium POE-lauryl sulfate; higher fatty acid amide sulfonates such as sodium stearoyl methyl taurate, sodium myristoyl methyl taurate, sodium cocoyl methyl taurate, and sodium cocoyl methyl taurate; POE-alkyl ether phosphates and salts thereof such as sodium POE-oleyl ether phosphate, sodium POE-cetyl ether phosphate, and POE-stearyl ether phosphate; phosphate esters and salts thereof such as potassium cetyl phosphate and cetyl phosphate; sulfosuccinates such as sodium di-2-ethylhexyl sulfosuccinate; alkyl benzene sulfonates such as sodium linear dodecyl benzene sulfonate; higher fatty acid ester sulfates such as sodium hydrogenated coconut oil fatty acid glycerin sulfate; and N-acyl glutamates such as monosodium lauroyl glutamate, sodium stearoyl glutamate, and sodium myristoyl glutamate.

[0045] Examples of cationic surfactants include fatty acid amidoamines such as stearamidopropyl dimethylamine and behenamidopropyl dimethylamine; monoalkyl quaternary ammonium salts such as cetrimonium chloride, steartrimonium chloride, behentrimonium chloride, steartrimonium bromide, cetrimonium methosulfate and behentrimonium methosulfate; and monoalkyl ether quaternary ammonium salts such as stearoxypropyltrimonium chloride and behenyl PG trimonium chloride. quaternary ammonium salts such as dialkyl quaternary ammonium salts, distearyldimonium chloride, dicocodimonium chloride, dialkyl (12 to 18 carbon atoms)dimonium chloride, and quaternium-18; dialkyl ester quaternary ammonium salts such as dicocoyl ethyl hydroxyethylmonium methosulfate and distearoyl ethyl hydroxyethylmonium methosulfate; and benzalkonium quaternary ammonium salts such as benzalkonium chloride and benzethonium chloride.

[0046] Examples of amphoteric surfactants include carbobetaine, sulfobetaine, imidazolinium betaine, and amidobetaine.

[0047] Examples of nonionic surfactants include POE-2-decyltetradecyl alcohol, POE-alkyl ethers such as polyoxyethylene oleyl ether and polyoxyethylene cetyl ether; sorbitan fatty acid esters such as sorbitan monostearate, sorbitan sesquistearate, sorbitan tristearate, sorbitan monooleate, and sorbitan sesquioleate; POE (20) sorbitan monoisostearate, POE (20) sorbitan monooleate, POE (20) sorbitan monostearate, and POE (20) sorbitan monococonut oil fatty acid esters. 0) POE-sorbitan fatty acid esters such as sorbitan and POE (80) sorbitan laurate; glycerin fatty acid esters such as glyceryl monostearate and glyceryl oleate; POE-glycerin fatty acid esters such as polyoxyethylene glyceryl stearate and polyoxyethylene glyceryl trioleate; POE-dihydrocholesterol esters; polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-6 ... POE-hydrogenated castor oils such as ethylenedioxy hydrogenated castor oil 80; POE castor oils such as POE (3) castor oil and POE (20) castor oil; POE-hydrogenated castor oil fatty acid esters such as POE-hydrogenated castor oil isostearate; POE-alkylaryl ethers; glycerin alkyl ethers such as cumyl alcohol, batyl alcohol, and selachyl alcohol; POE-glycerin alkyl ethers such as POE-monostearyl glyceryl ether; POE fatty acid esters such as polyoxyl stearate; sucrose palmitate, sucrose stearate Examples include sucrose fatty acid esters such as phosphate esters, sucrose oleate, sucrose isostearate, sucrose linoleate, and sucrose linolenate; polyethylene glycol fatty acid esters such as polyethylene glycol dioleate; and polyglycerin fatty acid esters such as alkyl polyglycosides, diglyceryl monostearate, diglyceryl monoisostearate, decaglyceryl monostearate, decaglyceryl monooleate, decaglyceryl pentaoleate, and hexaglyceryl polyricinoleate.

[0048] Examples of naturally occurring surfactants include lecithin, hydrogenated lecithin, saponin, sodium surfactin, and bile acid.

[0049] Examples of the organic solvent include POE-POP alkyl ethers (wherein the alkyl group has 10 to 26 carbon atoms) (POE-POP cetyl ethers such as POE(20)POP(4) cetyl ether, POE-POP decyltetradecyl ethers such as POE(30)POP(6) decyltetradecyl ether, POE-POP decyltetradecyl ethers such as POE(20)POP(6) decyltetradecyl ether, etc.); POE alkyl ethers (wherein the alkyl group has 10 to 26 carbon atoms) (POE oleyl ethers such as POE(50) oleyl ether, POE oleyl ethers such as POE(20) oleyl ether, POE lauryl ethers such as POE(25) lauryl ether); and solubilizers such as lauromacrogol.

[0050] When the remover of the present invention contains a surfactant, its concentration can be 0.01% by mass or more, 0.1% by mass or more, 1% by mass or more, 3% by mass or more, 5% by mass or more, or 10% by mass or more, based on the total amount of the remover. Within these ranges, denture adhesive can be removed more effectively. Furthermore, when the remover of the present invention contains a surfactant, its concentration can be 20% by mass or less, 10% by mass or less, 8% by mass or less, 6% by mass or less, or 4% by mass or less, based on the total amount of the remover. Generally, an excessive amount of surfactant can adversely reduce the cleaning effect of the formulation. However, within these ranges, the cleaning effect of the formulation is not reduced, and sufficient amounts of metal compounds and polar bases can be incorporated, resulting in a formulation that can fully demonstrate the denture adhesive removal effect.

[0051] The concentration of the surfactant relative to the total amount of the remover is 0.01 to 20 mass%, 0.01 to 10 mass%, 0.01 to 8 mass%, 0.01 to 6 mass%, 0.01 to 4 mass%; 0.1 to 20 mass%, 0.1 to 10 mass%, 0.1 to 8 mass%, 0.1 to 6 mass%, 0.1 to 4 mass%; 1 to 20 mass%, 1 to 10 mass%, 1 to 8 mass%, 1 to 6 mass%, 1 to 4 mass%; 3 to 20 mass%, 3 to 10 mass%, 3 to 8 mass%, 3 to 6 mass%, 3 to 4 mass%; 5 to 20 mass%, 5 to 10 mass%, 5 to 8 mass%, 5 to 6 mass%; and 10 to 20 mass%.

[0052] When the remover of the present invention contains a surfactant, the content thereof can be 0.001 parts by weight or more, 0.005 parts by weight or more, 0.01 parts by weight or more, 0.05 parts by weight or more, 0.1 parts by weight or more, 1 part by weight or more, 5 parts by weight or more, or 10 parts by weight or more per part by weight of the polar base. Within this range, denture adhesive can be effectively removed. Furthermore, the content of the surfactant can be 40 parts by weight or less, 30 parts by weight or less, 25 parts by weight or less, 20 parts by weight or less, 10 parts by weight or less, 5 parts by weight or less, 1 part by weight or less, or 0.5 parts by weight or less per part by weight of the polar base. Generally, an excessive amount of surfactant can adversely reduce the cleaning effect of the formulation. However, within this range, the cleaning effect of the formulation is not reduced, and sufficient amounts of metal compound and polar base can be incorporated, resulting in a formulation that can fully demonstrate the denture adhesive removal effect.

[0053] The content ratio of the surfactant relative to 1 part by mass of the polar base is 0.001 to 40 parts by mass, 0.001 to 30 parts by mass, 0.001 to 25 parts by mass, 0.001 to 20 parts by mass, 0.001 to 10 parts by mass, 0.001 to 5 parts by mass, 0.001 to 1 part by mass, 0.001 to 0.5 parts by mass; 0.005 to 40 parts by mass, 0.005 to 30 parts by mass, 0.0 05-25 parts by mass, 0.005-20 parts by mass, 0.005-10 parts by mass, 0.005-5 parts by mass, 0.005-1 parts by mass, 0.005-0.5 parts by mass; 0.01-40 parts by mass parts by weight, 0.01 to 30 parts by weight, 0.01 to 25 parts by weight, 0.01 to 20 parts by weight, 0.01 to 10 parts by weight, 0.01 to 5 parts by weight, 0.01 to 1 part by weight, 0.01 to 0.5 parts by weight Parts: 0.05 to 40 parts by weight, 0.05 to 30 parts by weight, 0.05 to 25 parts by weight, 0.05 to 20 parts by weight, 0.05 to 10 parts by weight, 0.05 to 5 parts by weight, 0.05 to 1 part by weight parts, 0.05 to 0.5 parts by mass; 0.1 to 40 parts by mass, 0.1 to 30 parts by mass, 0.1 to 25 parts by mass, 0.1 to 20 parts by mass, 0.1 to 10 parts by mass, 0.1 to 5 parts by mass, 0.1 ~1 part by mass, 0.1 to 0.5 parts by mass; 1 to 40 parts by mass, 1 to 30 parts by mass, 1 to 25 parts by mass, 1 to 20 parts by mass, 1 to 10 parts by mass, 1 to 5 parts by mass; 5 to 40 parts by mass, 5 to 30 parts by mass Parts by weight, 5 to 25 parts by weight, 5 to 20 parts by weight, 5 to 10 parts by weight, 1 to 5 parts by weight; 10 to 40 parts by weight, 10 to 30 parts by weight, 10 to 25 parts by weight, 10 to 20 parts by weight.

[0054] When the remover of the present invention contains a surfactant, the content thereof can be at least 0.01 parts by weight, at least 0.05 parts by weight, at least 0.1 parts by weight, at least 0.15 parts by weight, at least 0.5 parts by weight, at least 0.8 parts by weight, or at least 1 part by weight per part by weight of the metal compound. Within these ranges, denture adhesive can be effectively removed. Furthermore, the content of the surfactant can be no more than 20 parts by weight, no more than 10 parts by weight, no more than 5 parts by weight, or no more than 3 parts by weight per part by weight of the metal compound. Generally, an excessive amount of surfactant can adversely reduce the cleaning effect of the formulation. However, within these ranges, the cleaning effect of the formulation is not reduced, and sufficient amounts of metal compound and polar base can be incorporated, resulting in a formulation that can fully demonstrate the denture adhesive removal effect.

[0055] The content ratio of the surfactant relative to 1 part by mass of the metal compound is 0.01 to 20 parts by mass, 0.01 to 10 parts by mass, 0.01 to 5 parts by mass, 0.01 to 3 parts by mass; 0.05 to 20 parts by mass, 0.05 to 10 parts by mass, 0.05 to 5 parts by mass, 0.05 to 3 parts by mass; 0.1 to 20 parts by mass, 0.1 to 10 parts by mass, 0.1 to 5 parts by mass, 0.1 to 3 parts by mass; 0.15-20 parts by mass, 0.15-10 parts by mass, 0.15-5 parts by mass, 0.15-3 parts by mass; 0.5-20 parts by mass, 0.5-10 parts by mass, 0.5-5 parts by mass, 0.5-3 parts by mass Parts: 0.8 to 20 parts by weight, 0.8 to 10 parts by weight, 0.8 to 5 parts by weight, 0.8 to 3 parts by weight; 1 to 20 parts by weight, 1 to 10 parts by weight, 1 to 5 parts by weight, and 1 to 3 parts by weight.

[0056] Examples of pH adjusters include organic acids and salts thereof such as acetic acid, oxalic acid, maleic acid, fumaric acid, malonic acid, lactic acid, tartaric acid, citric acid, benzoic acid, methanesulfonic acid, succinic acid, malic acid, ascorbic acid, adipic acid, and benzoic acid; inorganic acids and salts thereof such as phosphoric acid, hydrochloric acid, nitric acid, and carbonic acid; inorganic bases such as potassium hydroxide and sodium hydroxide; and organic bases such as triethanolamine, diisopropanolamine, and triisopropanolamine.

[0057] Examples of the disinfecting component or preservative include glycerin fatty acid esters; parabens such as isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, methyl parahydroxybenzoate, sodium methyl parahydroxybenzoate, ethyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, butyl parahydroxybenzoate, propyl parahydroxybenzoate, and sodium propyl parahydroxybenzoate; benzoic acids such as benzoic acid, sodium benzoate, and benzyl benzoate; quaternary ammonium salts such as benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetylpyridinium chloride, tetraethylammonium bromide, and didecyldimethylammonium chloride; ethylenediaminetetraacetate; chlorhexidine salts such as chlorhexidine gluconate and chlorhexidine hydrochloride; isopropylmethylphenol; and hinokitiol.

[0058] Humectants include glycerin, sorbitol, and the like.

[0059] The stabilizer may include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole, and the like.

[0060] Examples of thickeners include guar gum, locust bean gum, carrageenan, xanthan gum, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, acrylate / alkyl methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, macrogol, and cellulose-based thickeners (methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, etc.).

[0061] Sweeteners include saccharin sodium, stevia extract, sucralose, palatinose, maltitol, xylitol, trehalose, and arabitol.

[0062] The flavorings include various essential oils, essential oil components such as menthol, and compound flavors.

[0063] The remover of the present invention can be in the form of a solid such as a powder, tablet, or gum, a liquid (including a viscous fluid form), or a paste. Furthermore, a liquid or paste preparation can also be soaked in a nonwoven fabric or the like to form a sheet. When used as an oral remover, as described below, it is preferable to use a gum, paste, or sheet to prevent aspiration in elderly people. Preparations in the form of a dry solid such as a powder or tablet can be prepared as a ready-to-use preparation that is mixed with water or the like at the time of use. In the case of a ready-to-use preparation, the composition of the remover of the present invention described above is the composition of a finished preparation that is mixed with water or the like at the time of use.

[0064] The remover of the present invention can be a denture adhesive remover for removing denture adhesive from dentures. It can also be a denture adhesive remover for removing denture adhesive from the oral cavity (oral mucosa), i.e., an oral denture adhesive remover. Denture adhesive removers are also sometimes called denture adhesive cleaners.

[0065] The amount of the remover of the present invention used can be 1.5 to 15 g, preferably 2 to 10 g, per gram of denture adhesive. After applying the remover of the present invention to the denture adhesive (by coating, spraying, pasting, etc.), the denture adhesive can be removed from the denture and the oral cavity by, for example, moving the denture adhesive with your hands or rubbing it with your fingers, a brush, or a cloth. If the remover of the present invention is left to stand for up to 60 seconds, preferably 5 to 10 seconds, after applying it to the denture adhesive, the adhesive strength of the denture adhesive is more effectively reduced, making it easier to remove.

[0066] The present invention encompasses a method for removing denture adhesive (e.g., a method for removing denture adhesive from dentures or the oral cavity), which includes applying a composition containing a polar base and at least one metal compound to the denture adhesive. In this method, the metal compound is a compound selected from the group consisting of: (1) a salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron with at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) a hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof. The metal compound may contain two or more metals, and may also contain two or more counterions to the metal ions. Examples include salts of the above metals with organic or inorganic acids and ammonia. In this method, the denture adhesive can be attached to the denture or oral cavity. The composition and properties of the composition containing a polar base and a metal compound are as described for the denture adhesive remover of the present invention. The amount of the composition containing a polar base and at least one metal compound used should be an effective amount, and can be 1.5 to 15 g, preferably 2 to 10 g, per 1 g of denture adhesive. The remover of the present invention can be applied to the denture adhesive by coating, spraying, or pasting. After the application step, a step of allowing the denture adhesive to which the composition has been applied to stand can be included, and this standing time can be within 60 seconds, preferably 5 to 10 seconds. Furthermore, a step of applying force to the denture adhesive to remove it from the denture or oral cavity can be included.

[0067] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.

[0068] (1) Preparation of denture adhesive remover Liquid to powder formulations having the compositions shown in Tables 1 to 7 were prepared by mixing the respective components.

[0069] (2) Performance Evaluation of Denture Adhesive Remover No. 1 The performance of the denture adhesive remover was evaluated by simulating the conditions of dentures and the oral cavity. 0.1 g of denture adhesive (product name: Additive-Free New Polygrip) was applied to a 70 x 70 mm, 2 mm thick glass plate and immersed in tap water. After 1 minute, the plate was removed, and another glass plate of the same size was placed over the denture adhesive. A 1 kg weight was then placed on top of the plate to apply a load. After 10 seconds, the weight was removed, and one of the glass plates was peeled off to obtain a specimen. 1 g of each formulation from the Examples or Comparative Examples was applied to the denture adhesive and its surrounding area. Immediately after application, the denture adhesive was rubbed with a finger and the state of release was scored on a 5-point scale according to the following criteria. A score of 2 or higher was considered "pass," indicating sufficiently effective and efficient removal. 0: Cannot be removed at all 1: When force is applied, the surface layer of the denture adhesive moves, but it cannot be peeled off 2: The surface layer of the denture adhesive moves with light force, and when strong force is applied, it can be almost completely peeled off 3: When strong force is applied, it can be completely peeled off 4: It can be completely peeled off with light force

[0070] The evaluation results are shown in Tables 1 to 7. The preparation of Comparative Example 1, which did not contain a polar base, the preparations of Comparative Examples 2 to 4, which contained calcium stearate, magnesium oxide, and calcium phosphate as metal compounds, respectively, and the preparation of Comparative Example 5, which did not contain a metal compound, were unable to remove the denture adhesive. In contrast, the preparations of Examples 1 to 57 were able to remove the denture adhesive.

[0071] The remover of the present invention acts on the denture adhesive, changing its physical properties and thereby promoting the release of the denture adhesive, so it is reasonably expected that if it can be removed from a glass plate, it can also be removed from the oral cavity. Furthermore, some of the example formulations have an irritating or unpleasant taste and are therefore not suitable for removing denture adhesive from the oral cavity, but are useful for removing denture adhesive from dentures.

[0072] (3) Performance Evaluation of Denture Adhesive Removers No. 2 The formulations of Examples and Comparative Examples that were judged to be suitable for use in the oral cavity from the standpoint of irritation, taste, etc. (Examples and Comparative Examples with irritation to the oral mucosa and unpleasant taste rated as ◯ or △ in Tables 1 to 7) were evaluated for their ability to remove denture adhesive in the human oral cavity. 0.2 g of denture adhesive (product name: Additive-Free New Poligrip) colored with Blue No. 1 was applied to the palate of one subject, and a splint tailored to the subject's palate was placed over the application. Ten minutes after application, the splint was removed, and the subject attempted to remove any remaining denture adhesive by wrapping a nonwoven fabric soaked in 1 g of the formulation of each Example or Comparative Example around a finger and wiping the palate. The wiping time was 30 seconds, and those that were successfully removed were rated "satisfactory." The formulation of Comparative Example 2 was composed of ingredients that did not cause irritation or an unpleasant taste. The results are also shown in Tables 1 to 7. When the formulations of the Examples, which were rated as either good or fair for irritation to the oral mucosa and unpleasant taste, were used, denture adhesive adhering to the oral cavity could be completely removed without damaging the oral cavity. Figure 1 shows the condition of the oral cavity before and after wiping with the formulation of Example 57. Similar conditions were observed with the formulations of the other Examples. Figure 2 also shows the condition of the oral cavity before and after wiping with the formulation of Comparative Example 2. When the formulation of Comparative Example 2 was used, the adhesiveness of the denture adhesive was not reduced, and it was not sufficiently removed by wiping for 30 seconds, leaving a thin layer of denture adhesive remaining in the oral cavity.

[0073] The remover of the present invention chemically reduces the adhesiveness of denture adhesives using a polar base and a metal compound, thereby enabling the effective and efficient removal of denture adhesives from the oral cavity and dentures. Furthermore, because it can be prepared using general-purpose ingredients that are suitable for oral use and have little irritation or unpleasant taste, it can be used in a wide range of fields, including dental care and nursing care, making it highly valuable as a commercial product.

Claims

1. A denture adhesive remover comprising a polar base and at least one metal compound, wherein the metal compound is a compound selected from the group consisting of: (1) a salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron with at least one compound selected from the group consisting of inorganic acids, organic acids, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) a hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof.

2. A denture adhesive remover according to claim 1, wherein the inorganic acid is a compound selected from the group consisting of hydrochloric acid, carbonic acid, nitric acid, nitrous acid, sulfuric acid, sulfurous acid, thiosulfuric acid, silicic acid, phosphoric acid, and hydrofluoric acid, and the organic acid is a compound selected from the group consisting of lactic acid, acetic acid, citric acid, gluconic acid, and hexacyanoic acid.

3. A denture adhesive remover according to claim 1 or 2, wherein the polar base is at least one selected from the group consisting of lower alcohols, higher alcohols, polyhydric alcohols, and glycol ethers.

4. A denture adhesive remover according to any one of claims 1 to 3, wherein the concentration of the polar base is 1 to 99% by mass based on the total amount of the denture adhesive remover.

5. A denture adhesive remover according to any one of claims 1 to 4, wherein the concentration of the metal compound is 0.01 to 97% by mass based on the total amount of the denture adhesive remover.

6. A denture adhesive remover according to any one of claims 1 to 5, wherein the content of the metal compound is 0.0005 to 20 parts by mass per part by mass of the polar base.

7. A denture adhesive remover according to any one of claims 1 to 6, further comprising a surfactant.

8. A denture adhesive remover according to claim 7, wherein the concentration of the surfactant is 0.01 to 20% by weight based on the total amount of the denture adhesive remover.

9. A denture adhesive remover according to claim 7 or 8, wherein the content of the surfactant is 0.01 to 20 parts by mass per 1 part by mass of the metal compound.

10. A denture adhesive remover according to any one of claims 1 to 9, further comprising water.

11. A denture adhesive remover according to claim 10, wherein the concentration of water is 0.001 to 90% by mass based on the total amount of the denture adhesive remover.

12. A denture adhesive remover according to any one of claims 1 to 11, which is used to remove denture adhesive from dentures or the oral cavity.

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