Liquid composition

Abstract

The present invention provides a liquid composition including at least a hypohalous acid salt (A), a radical-generating catalyst (B), and a buffering agent (C), the liquid composition being characterized by satisfying prescribed conditions.

Description

Liquid composition

[0001] The present invention relates to a liquid composition.

[0002] Various disinfectants and germicides have been developed to have bactericidal and antiseptic effects, but some bacteria form spores, which are extremely durable cell structures, and general disinfectants (such as alcohol-based disinfectants) may not be effective enough to kill bacteria.

[0003] Radicals are important chemical species that are widely used due to their high reactivity and strong oxidizing power. For example, when bacteria or viruses come into contact with radicals, their oxidizing power causes them to disappear (also known as inactivate), resulting in sterilization and deodorization effects. Radicals are therefore used in a variety of fields, including medicine, hygiene, food processing, and water treatment.

[0004] In recent years, highly safe sterilization techniques that utilize radicals and are applicable to biological tissues have been developed. For example, Patent Document 1 discloses a drug that includes a radical-generating catalyst and a radical-generating source, wherein the radical-generating catalyst includes at least one of ammonium and its salt, and a substance having at least one of Lewis acidity and Bronsted acidity, or both.

[0005] JP 2017-109978 A

[0006] An object of the present invention is to provide a liquid composition containing a radical-generating catalyst having excellent long-term stability, a haloid salt, and a buffer substance.

[0007] The agent described in Patent Document 1, which contains a radical-generating catalyst and a radical-generating source, particularly halous acid salts, is mainly provided as a liquid composition and is highly reactive and has strong oxidizing power. Therefore, the present inventors conducted extensive research to provide a highly concentrated liquid composition that maintains its effect (e.g., bactericidal effect) for a long period of time, is suitable for transportation, and can maintain its effect even when diluted. As a result, they found that by satisfying certain conditions, it is possible to provide a liquid composition with excellent long-term stability that contains a radical-generating catalyst, a radical-generating source (e.g., halous acid salts), and a buffer substance, and they have completed the present invention. That is, the present invention includes the following.

[0008] [1] A liquid composition comprising at least a halous acid salt (A), a radical-generating catalyst (B), and a buffer substance (C), which satisfies the following conditions (I) to (IV): (I) the halous acid salt (A) is at least one selected from the group consisting of a halous acid, a halous acid ion, and a halous acid salt, and is contained in an amount of 0.3 to 20.0 mass % in the liquid composition; (II) the radical-generating catalyst (B) is represented by the following chemical formula (1): [In the above chemical formula (1), R １１ , R ２１ , R ３１ , and R ４１ are each a hydrogen atom or an alkyl group, and may contain an ether bond, a ketone (carbonyl group), an ester bond, an amide bond, or an aromatic ring; R １１ , R ２１ , R ３１ , and R ４１ may be the same or different, or R １１ , R ２１ , R ３１ , and R ４１ Two or more of these are united and bonded to N ＋ may form a cyclic structure together with X, and the cyclic structure may be saturated or unsaturated, may be an aromatic ring or a non-aromatic ring, and may or may not have one or more substituents; －(III) the total concentration of the halous acid salt (A) and the radical-generating catalyst (B) contained in the liquid composition is 1.3 to 30.0 mass%; and (IV) the buffer substance (C) contained in the liquid composition contains a phosphate ion, the concentration of the phosphate ion contained in the liquid composition is 0.01 to 1.50 mass%, and the mass ratio of the phosphate ion to the mass of the halous acid salt (A) is 0.33 or more, where the mass of the halous acid salt (A) is taken as 100. [2] The liquid composition according to item 1, wherein the content of the halous acid salt (A) is 3.0 to 20.0 mass%. [3] The liquid composition according to item 1 or 2, wherein the mass ratio of the halous acid salt (A) to the radical-generating catalyst (B) is 1:3 to 3:1. [4] The radical-generating catalyst (B) is represented by the following chemical formula (2): [In the chemical formula (2), R is an alkyl group, and may contain an ether bond, a ketone (carbonyl group), an ester bond, an amide bond, or an aromatic ring.] [5] The liquid composition according to any one of items 1 to 3, wherein the ammonium salt represented by chemical formula (2) is benzethonium chloride and / or benzalkonium chloride. [6] The liquid composition according to any one of items 1 to 3, wherein the radical-generating catalyst (B) is at least one selected from the group consisting of paraquat, ammonium chloride, dequalinium chloride, cetylpyridinium chloride, and didecyldimethylammonium chloride. [7] The liquid composition according to any one of items 1 to 6, wherein the halo acid of the halo acid salt (A) is chlorous acid, the halo ion is chlorite ion, and the halo acid salt is chlorite.

[0009] According to the present invention, it is possible to provide a liquid composition that has excellent long-term stability, low flammability, and excellent safety, and that contains a high concentration of a radical-generating source and a radical-generating catalyst.

[0010] Hereinafter, the embodiments of the present invention will be described in more detail.

[0011] In one embodiment, the present invention provides a liquid composition comprising at least a halous acid salt (A), a radical-generating catalyst (B), and a buffer substance (C), which satisfies the following conditions (I) to (IV): (I) the halous acid salt (A) is at least one selected from the group consisting of a halous acid, a halous acid ion, and a halous acid salt, and is contained in an amount of 0.3 to 20.0 mass % in the liquid composition; (II) the radical-generating catalyst (B) is a compound represented by the following chemical formula (1): [In the above chemical formula (1), R １１ , R ２１ , R ３１ , and R ４１ are each a hydrogen atom or an alkyl group, and may contain an ether bond, a ketone (carbonyl group), an ester bond, an amide bond, or an aromatic ring; R １１ , R ２１ , R ３１ , and R ４１ may be the same or different, or R １１ , R ２１ , R ３１ , and R ４１ Two or more of these are united and bonded to N ＋ may form a cyclic structure together with X, and the cyclic structure may be saturated or unsaturated, may be an aromatic ring or a non-aromatic ring, and may or may not have one or more substituents; －is an anion (excluding peroxodisulfate ion). ] and is contained in the liquid composition at 0.3 to 20.0 mass %; (III) the total concentration of the halous acid salt (A) and the radical-generating catalyst (B) contained in the liquid composition is 1.3 to 30.0 mass %; and (IV) the buffering substance (C) contained in the liquid composition contains a phosphate ion, the concentration of the phosphate ion contained in the liquid composition is 0.01 to 1.50 mass %, and the mass ratio of the phosphate ion when the mass of the halous acid salt (A) is taken as 100 is 0.33 or more.

[0012] Each element constituting the present invention will be described below.

[0013] <Halogen salt (A)> The halogen salt (A) used in the present invention acts as a radical generating source and may include at least one selected from the group consisting of halous acid, halous acid ion, and halous acid salt.From the viewpoint of mild reactivity with the radical generating catalyst and easy reaction control, the halogen salt (A) is preferably one selected from the group consisting of chlorous acid, chlorous acid ion, and chlorite.In one embodiment, the halogen salt (A) may be sodium chlorite.

[0014] In the liquid composition of the present invention, the content of the halous acid salt (A) may be 0.3 to 20.0 mass% when the liquid composition is taken as 100 mass% (for example, the above-mentioned condition (I)), and may be, for example, 0.5 to 20.0 mass%, 1.0 to 15.0 mass%, 3.0 to 20.0 mass%, 3.0 to 15.0 mass%, or 4.0 to 12.0 mass%.

[0015] <Radical-generating catalyst (B)> The radical-generating catalyst (B) used in the present invention has the effect of catalyzing the generation of radicals from the radical-generating source used in the present invention. The radical-generating catalyst (B) may be used alone or in combination of two or more.

[0016] The radical-generating catalyst (B) used in the present invention is preferably an ammonium or a salt thereof having Lewis acid properties. Such an ammonium may be, for example, a quaternary ammonium, or a tertiary, secondary, or primary ammonium, but is preferably a quaternary ammonium.

[0017] The radical-generating catalyst (B) used in the present invention may be, for example, a cationic surfactant, and among these, a quaternary ammonium type cationic surfactant is preferred. Examples of quaternary ammonium type cationic surfactants include benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, hexadecyltrimethylammonium bromide, dequalinium chloride, edrophonium, didecyldimethylammonium chloride, tetramethylammonium chloride, tetrabutylammonium chloride, benzyltriethylammonium chloride, oxitropium, carbachol, glycopyrronium, safranine, sinapine, tetraethylammonium bromide, suxamethonium, sphingomyelin, denatonium, trigonelline, neostigmine, paraquat, pyridostigmine, phellodendrin, pralidoxime methyl iodide, betaine, betanin, bethanechol, betalain, lecithin, and cholines (choline chlorides such as benzoylcholine chloride and lauroylcholine chloride hydrate, phosphocholine, acetylcholine, choline, dipalmitoylphosphatidylcholine, and choline bitartrate). These may be used alone or in combination of two or more.

[0018] The radical-generating catalyst (B) used in the present invention is not limited to the quaternary ammonium type cationic surfactant.

[0019] The radical-generating catalyst (B) used in the present invention may be, for example, an ammonium salt represented by the following chemical formula (1).

[0020]

[0021] In the chemical formula (1), R １１ , R ２１ , R ３１ , and R４１ are each a hydrogen atom or an alkyl group, and may contain an ether bond, a ketone (carbonyl group), an ester bond, an amide bond, or an aromatic ring; R １１ , R ２１ , R ３１ , and R ４１ may be the same or different, or R １１ , R ２１ , R ３１ , and R ４１ Two or more of these are united and bonded to N ＋ and X may form a cyclic structure together with the ring, and the cyclic structure may be saturated or unsaturated, may be an aromatic ring or a non-aromatic ring, and may or may not have one or more substituents; － is an anion (excluding peroxodisulfate).

[0022] Specific examples of the ammonium salt represented by the chemical formula (1) include, for example, benzethonium chloride, benzalkonium chloride, hexadecyltrimethylammonium chloride, tetramethylammonium chloride, ammonium chloride, and tetrabutylammonium chloride, and may be at least one selected from the group consisting of these. In one embodiment, the radical-generating catalyst (B) may be at least one selected from the group consisting of paraquat, ammonium chloride, dequalinium chloride, cetylpyridinium chloride, and didecyldimethylammonium chloride. Since paraquat, ammonium chloride, dequalinium chloride, cetylpyridinium chloride, and didecyldimethylammonium chloride are quaternary ammonium salts, they function as radical-generating catalysts, and when combined with a halous acid salt, they exhibit a disinfecting effect. Furthermore, since these compounds have a disinfecting effect on their own, a synergistic effect is also expected.

[0023] The ammonium salt represented by the chemical formula (1) may be, for example, an ammonium salt represented by the following chemical formula (1a):

[0024]

[0025] In the chemical formula (1a), R １１１is an alkyl group having 5 to 40 carbon atoms, which may contain an ether bond, a ketone (carbonyl group), an ester bond, an amide bond, or an aromatic ring; R ２１ and X － is the same as the above chemical formula (1).

[0026] In the chemical formula (1a), R ２１ is preferably a methyl group or a benzyl group, and the benzyl group may or may not have a hydrogen atom on the benzene ring substituted with one or more optional substituents, and examples of the optional substituents include an alkyl group, an unsaturated aliphatic hydrocarbon group, an aryl group, a heteroaryl group, a halogen, a hydroxy group (—OH), a mercapto group (—SH), and an alkylthio group (—SR, where R is an alkyl group).

[0027] The ammonium salt represented by the chemical formula (1) is preferably an ammonium salt represented by the following chemical formula (2).

[0028]

[0029] In the chemical formula (2), R is an alkyl group, which may contain an ether bond, a ketone (carbonyl group), an ester bond, an amide bond, or an aromatic ring. The ammonium salt represented by the chemical formula (2) is preferably benzethonium chloride and / or benzalkonium chloride.

[0030] Benzethonium chloride (Bzn ＋ Cl － ) can be represented, for example, by the following chemical formula (3): In formula (3), Me is a methyl group; ｔ Bu is a tertiary butyl group. Benzalkonium chloride can be represented by, for example, the above-mentioned chemical formula (2), where R is an alkyl group having 8 to 18 carbon atoms.

[0031] In the chemical formulas (1) and (1a), X － is any anion and is not particularly limited. －is not limited to an anion with a monovalent charge, but may be an anion with any valence such as divalent or trivalent. When the anion has multiple charges such as divalent or trivalent, for example, the number of ammonium (monovalent) molecules in the chemical formulas (1) and (1a) is the number of anion molecules multiplied by the valence of the anion (for example, when the anion is divalent, the number of ammonium (monovalent) molecules is twice the number of anion molecules). X － Examples of the cations include halogen ions (fluoride ions, chloride ions, bromide ions, iodide ions), acetate ions, nitrate ions, and sulfate ions.

[0032] The ammonium salt used as the radical-generating catalyst (B) in the present invention contains an ammonium structure (N ＋ Furthermore, the ammonium salt used as the radical-generating catalyst (B) in the present invention may be one in which a plurality of molecules associate with each other through π-electron interaction to form a dimer, trimer, or the like.

[0033] Furthermore, when the radical-generating catalyst (B) (e.g., organic ammonium salt, etc.) used in the present invention has isomers such as tautomers or stereoisomers (e.g., geometric isomers, conformational isomers, and optical isomers), any of the isomers can be used in the present invention unless otherwise specified.

[0034] Furthermore, when the radical-generating catalyst (B) used in the present invention (e.g., an organic ammonium salt) can form a salt, the salt may be an acid addition salt or a base addition salt. Furthermore, the acid that forms the acid addition salt may be an inorganic acid or an organic acid, and the base that forms the base addition salt may be an inorganic base or an organic base. Examples of inorganic acids include, but are not limited to, sulfuric acid, phosphoric acid, hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, hypofluorite acid, hypochlorous acid, hypobromous acid, hypoiodous acid, fluorite acid, chlorous acid, bromous acid, iodous acid, fluoric acid, chloric acid, bromic acid, iodic acid, perfluoric acid, perchloric acid, perbromic acid, and periodic acid. Examples of organic acids include, but are not limited to, p-toluenesulfonic acid, methanesulfonic acid, oxalic acid, p-bromobenzenesulfonic acid, carbonic acid, succinic acid, citric acid, benzoic acid, and acetic acid. The inorganic base is not particularly limited, but examples thereof include ammonium hydroxide, alkali metal hydroxides, alkaline earth metal hydroxides, carbonates, and bicarbonates, and more specifically, examples thereof include sodium hydroxide, potassium hydroxide, potassium carbonate, sodium carbonate, sodium bicarbonate, potassium bicarbonate, calcium hydroxide, and calcium carbonate. The organic base is also not particularly limited, but examples thereof include ethanolamine, triethylamine, and tris(hydroxymethyl)aminomethane. The method for producing these salts is also not particularly limited, and they can be produced, for example, by adding the above-mentioned acid or base to the compound as appropriate using a known method.

[0035] Furthermore, in the radical-generating catalyst (B) used in the present invention, the chain substituent (for example, a hydrocarbon group such as an alkyl group or an unsaturated aliphatic hydrocarbon group) may be linear or branched unless otherwise specified, and the number of carbon atoms therein is not particularly limited, but is preferably 1 to 40, 1 to 32, 1 to 24, 1 to 18, 1 to 12, 1 to 6, or 1 to 2 (2 or more in the case of an unsaturated hydrocarbon group). Furthermore, in the present invention, the number of ring members (the number of atoms constituting the ring) of a cyclic group (for example, an aryl group, a heteroaryl group, etc.) is not particularly limited, but is preferably 5 to 32, 5 to 24, 6 to 18, 6 to 12, or 6 to 10, respectively. Furthermore, when an isomer exists in a substituent or the like, any isomer may be used unless otherwise specified. For example, a simple reference to a "naphthyl group" may mean either a 1-naphthyl group or a 2-naphthyl group.

[0036] The radical-generating catalyst (B) used in the present invention may be contained in the liquid composition in an amount of 0.3 to 20.0 mass% (for example, the above-mentioned condition (II)), preferably 1.0 to 15.0 mass%, more preferably 2.0 to 10.0 mass%, when the liquid composition is taken as 100 mass%.

[0037] In the present invention, the total concentration of the halous acid salt (A) and the radical-generating catalyst (B) contained in the liquid composition may be 1.3 to 30.0 mass% (e.g., the above-mentioned condition (III)) when the liquid composition is taken as 100 mass%, and may be, for example, 2.0 to 25.0 mass%, 3.0 to 25.0 mass%, or 5.0 to 20.0 mass%.

[0038] In the liquid composition of the present invention, the concentration ratio of the halous acid salt (A) to the radical-generating catalyst (B) in the composition (halous acid salt (A) / radical-generating catalyst (B)) is not particularly limited and can be set appropriately.

[0039] In one embodiment, the mass ratio of the halous acid salt (A) to the radical-generating catalyst (B) contained in the liquid composition is preferably 1:3 to 3:1, and may be, for example, 1:2 to 2:1, or about 1: 1. In this specification, a numerical value followed by "about" can be interpreted as including a range of ±20%, preferably a range of ±10%, and more preferably a range of ±5% of the numerical value.

[0040] In the present invention, a buffer substance (C) is used in the liquid composition. The buffer substance (C) has the function of maintaining the pH of the liquid composition within a desired range. In the present invention, for example, a compound containing carbonate ions, bicarbonate ions, borate ions, ammonium ions, hydrogen phosphate ions, or phosphate ions, 3-cyclohexylaminopropanesulfonic acid (CAPS), 3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid (CAPSO), or 2-cyclohexylaminoethanesulfonic acid (CHES), may be used. In one aspect, the buffer substance (C) used in the present invention is preferably a compound containing phosphate ions. The phosphate ions referred to here may include hydrogen phosphate ions and dihydrogen phosphate ions generated by the equilibration of phosphate salts. For example, potassium dihydrogen phosphate, sodium dihydrogen phosphate, dipotassium hydrogen phosphate, disodium hydrogen phosphate, tripotassium phosphate, trisodium phosphate, etc. may be used. These may be used alone or in combination of two or more.

[0041] In the present invention, the concentration of phosphate ions contained in the liquid composition may be 0.01 to 1.50% by mass (e.g., the above-mentioned condition (IV)), preferably 0.05 to 1.50% by mass, and more preferably 0.05 to 1.34% by mass, when the liquid composition is taken as 100% by mass. Furthermore, in the present invention, the concentration of phosphate ions contained in the liquid composition may be such that the mass ratio of phosphate ions to the mass of the halous acid salt (A) is 0.33 or more (e.g., the above-mentioned condition (IV)), and may be, for example, a concentration of 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, or 1.5 or more.

[0042] In one embodiment, the liquid composition of the present invention contains water as a solvent for dissolving or dispersing the halite (A), the radical-generating catalyst (B), and the buffer substance (C). Examples of water include purified water, ion-exchanged water, distilled water, filtered water, and sterilized water.

[0043] Furthermore, the liquid composition of the present invention is preferably neutral or alkaline in nature. If the liquid composition is acidic, the radical generating source and the radical generating catalyst react rapidly, generating radicals, making it difficult to generate radicals stably for a long period of time. In the present invention, the aqueous radicals (active species) generated in the liquid composition are maintained in this state in a neutral or alkaline environment. When bacteria, viruses, or the like that are the target of the reaction are present, the aqueous radicals present in the liquid composition act to eliminate these radicals, but new radicals are generated from within the liquid composition. This allows radicals to be generated when needed. The liquid composition of the present invention preferably has a pH of 7 to 13 immediately after production, and may have a pH of, for example, 8 to 13, 9 to 13, or 10 to 12.

[0044] The liquid composition of the present invention can be produced by dissolving the halous acid salt (A), the radical-generating catalyst (B) and the buffer substance (C) in a solvent, and adjusting the pH as necessary.

[0045] The liquid composition provided by the present invention is chemically stable for a long period of time, and exhibits excellent effects such as little change in pH and little decomposition of halous acid salts, even when stored at 40°C for 6 months. The liquid composition provided by the present invention also has low flammability and high safety. Furthermore, the liquid composition provided by the present invention exhibits sufficient disinfecting effect even when diluted to a commonly used concentration of halous acid salts (e.g., about 160 ppm by mass of halous acid salts). The liquid composition provided by the present invention is used in a diluted state where the halous acid salts contained in the liquid composition, which act as a radical generating source, exhibit a disinfecting effect, and therefore can be transported at a high concentration until it is transported to the desired location.

[0046] The method and dilution ratio for diluting the liquid composition provided by the present invention for use as a disinfectant are not particularly limited, but for example, the halous acid salts are preferably mixed in the solution immediately before use at 0.01 to 1500 ppm by mass, more preferably 0.05 to 1000 ppm by mass, and even more preferably 0.1 to 250 ppm by mass. The solvent used for dilution may be water or an aqueous solution containing a buffer substance (C).

[0047] The present invention will be further described below with reference to examples, but the present invention is not limited to the following examples.

[0048] [Experiment 1] Sodium chlorite was used as the halite salt (A), benzethonium chloride or benzalkonium chloride as the radical-generating catalyst (B), and trisodium phosphate dodecahydrate as the buffer substance (C), and each was dissolved in pure water to the concentrations shown in the tables to prepare test samples 1 to 135 (Tables 1-1 to 1-3, Table 2). The tables also show the phosphate ion concentration (mass % in the liquid composition) when trisodium phosphate dodecahydrate was dissolved.

[0049] <Test sample composition>

[0050] 2. Test Results The test results in the above table are displayed according to the following standards.

[0051] <Stability Test (1)> 100 mL of each test sample was dispensed into a 100 mL polyethylene bottle, and after storage for 6 months in a thermostatic chamber set at 40° C., the change in pH was confirmed by the glass electrode method. A pH change of 3.0 or more was evaluated as "-", a change of 2.0 or more but less than 3.0 was evaluated as "+", a change of 1.0 or more but less than 2.0 was evaluated as "++", and a change of less than 1.0 was evaluated as "+++".

[0052] <Stability test (2)> Each test sample is dispensed into a 100mL polyethylene bottle in an amount of 100mL, and after storing in a thermostatic chamber set at 40°C for 6 months, the chlorite ion concentration and chlorate ion concentration are measured by anion chromatography (see Table 3 below).As the relative value of the chlorate ion concentration when the chlorite ion concentration is set to 100, the value of 20 or more is evaluated as "-", the value of 10 or more but less than 20 is evaluated as "+", the value of 5 or more but less than 10 is evaluated as "++", and the value of less than 5 is evaluated as "+++".In addition, "N / A" indicates that the sample does not contain chlorite ion, and therefore the test has not been carried out on the sample.

[0053] Anion chromatography conditions

[0054] <Flammability Test (Safety)> Wood flour (Japanese cedar sapwood) with a particle size that passes through a standard mesh sieve of 500 μm but not a standard mesh sieve of 250 μm was dried at 105°C for 4 hours and then stored in a desiccator containing drying silica gel at 20±5°C for at least 24 hours. 15 g of the wood flour was placed in a conical cup and inverted onto a flat-bottom evaporating dish to form a conical pile. This conical pile was left in the test location (temperature 20±5°C, humidity 50±10%) for 1 hour. 15 g of test sample was poured evenly over the wood flour using a syringe. The flammability test was conducted as used to determine whether the wood flour is classified as a Class 6 hazardous material (oxidizing liquid) under the Fire Service Act. Specifically, a nichrome wire ring was used as the ignition device, heated to approximately 1,000°C by passing electricity through it. The ignition tool was placed from above on the base of the cone-shaped pile prepared above, and the contact was maintained for a maximum of 10 seconds until it was clear that the pile was completely ignited and flaming, or that it had not ignited at all. In this test, the time until the flame went out was measured to determine the risk, with a rating of "-" if it was 30 seconds or longer and a rating of "+" if it was less than 30 seconds.

[0055] The initial pH of test samples Nos. 4, 5, 6, 8, 10, 13, 15, 17, 20, 22, and 24 immediately after production was 10 to 12, as shown below, which was a pH that allowed radicals to be generated when required.

[0056] [Experiment 2] <Disinfection Effect Verification Test (Functionality)> Test samples Nos. 4 to 135 were mixed with Mueller-Hinton II liquid medium so that the sodium chlorite concentration was 160 ppm by mass, and used as test samples. Furthermore, 10 g of meat extract, 10 g of peptone, 3 g of sodium chloride, and 1,000 g of distilled water were mixed, dissolved by heating, adjusted to a pH of 7.2 to 7.4, and sterilized under high pressure at 121°C for 15 minutes to prepare a normal medium. The test bacterium Escherichia coli was inoculated into the normal medium, cultured at 32.5°C for 24 hours, and then the bacteria count was increased to 10.0 using physiological saline. ７ The test bacterial solution was adjusted to 1000 mg / mL.

[0057] Each test sample was inoculated with a test bacterial solution and cultured for 24 hours in a thermostatic chamber set at 32.5° C. After the culture, the presence or absence of growth of the test bacteria was observed with the naked eye.

[0058] In test samples Nos. 4 to 135, no growth of the test bacteria was observed.

Claims

1. A liquid composition comprising at least a halous acid salt (A), a radical-generating catalyst (B), and a buffer substance (C), which satisfies the following conditions (I) to (IV): (I) the halous acid salt (A) is at least one selected from the group consisting of a halous acid, a halous acid ion, and a halous acid salt, and is contained in an amount of 0.3 to 20.0 mass % in the liquid composition; (II) the radical-generating catalyst (B) is represented by the following chemical formula (1): [In the above chemical formula (1), R １１ , R ２１ , R ３１ , and R ４１ are each a hydrogen atom or an alkyl group, and may contain an ether bond, a ketone (carbonyl group), an ester bond, an amide bond, or an aromatic ring; R １１ , R ２１ , R ３１ , and R ４１ may be the same or different, or R １１ , R ２１ , R ３１ , and R ４１ Two or more of these are united and bonded to N ＋ may form a cyclic structure together with X, and the cyclic structure may be saturated or unsaturated, may be an aromatic ring or a non-aromatic ring, and may or may not have one or more substituents; － is an anion (excluding peroxodisulfate ion). ] and is contained in the liquid composition at 0.3 to 20.0 mass %; (III) the total concentration of the halous acid salt (A) and the radical-generating catalyst (B) contained in the liquid composition is 1.3 to 30.0 mass %; and (IV) the buffering substance (C) contained in the liquid composition contains a phosphate ion, the concentration of the phosphate ion contained in the liquid composition is 0.01 to 1.50 mass %, and the mass ratio of the phosphate ion when the mass of the halous acid salt (A) is taken as 100 is 0.33 or more.

2. The liquid composition according to claim 1, wherein the content of the halous acid salt (A) is 3.0 to 20.0 mass %.

3. The liquid composition according to claim 1, wherein the mass ratio of the halous acid salt (A) to the radical-generating catalyst (B) is 1:3 to 3:

1.

4. The radical-generating catalyst (B) is represented by the following chemical formula (2):

2. The liquid composition according to claim 1, which is an ammonium salt represented by the following chemical formula (2): [In the chemical formula (2), R is an alkyl group, and may contain an ether bond, a ketone (carbonyl group), an ester bond, an amide bond, or an aromatic ring.] 5. The liquid composition according to claim 4, wherein the ammonium salt represented by the chemical formula (2) is benzethonium chloride and / or benzalkonium chloride.

6. The liquid composition according to claim 1, wherein the radical-generating catalyst (B) is at least one selected from the group consisting of paraquat, ammonium chloride, dequalinium chloride, cetylpyridinium chloride, and didecyldimethylammonium chloride.

7. The liquid composition according to claim 1, wherein the halo acid of the halo hydride salt (A) is chlorous acid, the halo hydride ion is chlorite ion, and the halo hydride salt is chlorite.

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