Lipopolysaccharide-binding peptoids, and compositions and methods of use thereof
WO2025189073A8 Publication Date: 2025-10-02MAXWELL BIOSCIENCES INC
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Patent Information
- Application Number
- PCT/US2025/018867
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-03-08
- Filing Date
- 2025-03-07
- Publication Date
- 2025-10-02
AI Technical Summary
Technical Problem
The development of therapeutic agents capable of neutralizing lipopolysaccharides (LPS) to improve outcomes in conditions such as sepsis, autoimmune diseases, and inflammation associated with bacterial infections is challenging.
Method used
The use of LPS-binding peptoid compounds that can bind to LPS, mimicking structural aspects of LPS-binding proteins, to neutralize or prevent the interaction of LPS with immune cells and reduce the release of pro-inflammatory cytokines.
Benefits of technology
The peptoid compounds effectively treat or prevent a wide range of pathological conditions caused by or associated with LPS, including sepsis and autoimmune diseases, by reducing LPS activity and interaction with immune cells, thereby mitigating inflammation and immune response.
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Abstract
Lipopolysaccharide-binding peptoids, and compositions and methods of use thereof, are described.
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