Combinations of one or more alkylamidothiazoles and ferulic acid and / or one or more ferulic acid salts and / or one or more ferulic acid glycosides and cosmetic preparations containing such combinations

Abstract

The present invention belongs to the cosmetic field, and relates to active ingredient combinations of a) one or more alkylamidothiazoles, and b) ferulic acid and / or one or more ferulic acid salts and / or one or more ferulic acid glycosides, c) in a cosmetic excipient, and cosmetic preparations containing such combinations. Ferulic acid and / or one or more ferulic acid salts and / or one or more ferulic acid glycosides may be used to prevent or reduce the deterioration of alkylamidothiazoles caused by oxidative processes and / or heat and / or UV-light in cosmetic preparations containing one or more alkylamidothiazoles.

Description

Combinations of one or more alkylamidothiazoles and ferulic acid and / or one or more ferulic acid salts and / or one or more ferulic acid glycosides and cosmetic preparations containing such combinationsTechnical fieldThe present invention belongs to the cosmetic field, and relates to combinations of one or more alkylamidothiazoles and ferulic acid and / or one or more ferulic acid salts and / or one or more ferulic acid glycosides, and cosmetic preparations containing such combinations.Background artIn general, cosmetic products not only serve to look beautiful and attractive, but with their effect they make a decisive contribution to increased self-esteem and the well-being of people. Accordingly, a wide variety of cosmetic products are used for the daily cleaning and care of human skin. For example, cosmetic preparations for the care of human skin are known from DE 102011083259 A1 , which contain alkylamidothiazoles.The alkylamidothiazoles used are used in the cosmetic preparations to combat and prevent undesired pigmentation of the skin. In this way, the user's complexion can be decisively improved.It is also known from DE 102013226711 A1 that alkylamidothiazoles can be used in cosmetic or dermatological preparations for the prophylaxis and treatment of sensitive skin, itching, dry skin and inflammatory symptoms of human skin. The document discloses various cosmetic O / W emulsions for application to human skin.Furthermore, DE 102013204110 A1 discloses a large number of cosmetic preparations for the care of human skin containing alkylamidothiazoles.A particularly effective lightening of human skin is achieved by the combined use of alkylamidothiazoles with one or more cyclodextrins.However, the fact that the person skilled in the art knows a large number of cosmetic preparations containing alkylamidothiazoles must not obscure the fact that a large number of problems can arise when formulating cosmetic or dermatological preparations.A disadvantage, for example, is the fact that the color of newly produced cosmetic or dermatological preparations changes during storage. This occurs more intensely when thepreparation is exposed to light.This circumstance creates considerable difficulties for manufacturers of cosmetic preparations, since it is necessary to carry out studies on the color stability of cosmetic preparations.This often requires a large number of approaches, which significantly increases the development costs of cosmetic products.It is therefore desirable to provide systems and methods which effectively prevent or minimize degradation processes in cosmetic or dermatological preparations, so that the development costs can be minimized. The problem of degradation processes in cosmetic or dermatological preparations is also relevant for the consumer.Products are often selected based on their optical appearance or their skin. However, if the white appearance of a product deteriorates over the storage period, the consumer is usually annoyed because the decisive purchase criterion is no longer met.The color stability of cosmetic or dermatological preparations can in principle be assessed by specially trained personnel who compare the color of a freshly prepared preparation (within 24 hours of preparation) and after a corresponding storage time. However, the color changes of the products are always very difficult to judge. It is, therefore, advantageous using a special instrument called Digi-Eye on the color change.Summary of the inventionOne object of the present invention was therefore to provide a way of preventing or minimizing degradation processes in cosmetic products in a particularly effective manner, so that color stability is ensured.This object is achieved by active ingredient combinations of a) one or more alkylamidothiazoles, and b) ferulic acid and / or one or more ferulic acid salts and / or one or more ferulic acid glycosides, and optionally, tocopherol (e.g., a-tocopherol and / or p-tocopherol), c) in a cosmetic excipient.Astonishingly the combination of ferulic acid and / or one or more ferulic acid salts and / or one or more ferulic acid glycosides and tocopherol acts in a synergistic way in comparisonto the single substances to prevent or reduce the deterioration of alkylamidothiazoles caused by oxidative processes and / or heat and / or LJV-light.Ferulic acid (4-hydroxy-3-methoxycinnamic acid, caffeic acid 3-methyl ether) is known to have antioxidant properties. It is characterized by the structural formula(cis-isomer)It is widespread in plants and occurs e.g., in beets, grains and the latex of the eponymous umbelliferous plants Ferula asafoetida and Ferula nartex. The E form is a colorless crystalline solid under normal conditions, the Z form is a yellowish oil under normal conditions.Another embodiment of the present invention is cosmetic preparations containing such combinations.Yet another embodiment of the present invention is use of b) ferulic acid and / or one or more ferulic acid salts and / or one or more ferulic acid glycosides, and optionally, tocopherol (e.g., a-tocopherol and / or p-tocopherol), c) in a cosmetic excipientto prevent or reduce the deterioration of alkylamidothiazoles caused by oxidative processes and / or heat and / or LJV-light in cosmetic preparations containing one or more alkylamidothiazoles.Advantageous embodiments of the present invention are also cosmetic or dermatological preparations with a content of such active ingredient combination, and the use thereof for lightening human skin.Advantageously, preparations according to the invention comprise formulations, where the total amount of the one or more alkylamidothiazoles is e.g., 0.00001% by weight to 10% by weight, preferably 0.001% by weight to 5% by weight, in particular 0.005% by weight to 3% by weight, based on the total weight of the preparations, in order to provide cosmetic preparations.Advantageously, preparations according to the invention comprise formulations, where the total amount of the ferulic acid and / or one or more ferulic acid salts and / or one or more ferulic acid glycosides is e.g., 0.00001% by weight to 10% by weight, preferably 0.001% by weight to 5% by weight, in particular 0.005% by weight to 3% by weight, based on the total weight of the preparations, in order to provide cosmetic preparations.Advantageously, preparations according to the invention comprise formulations, may additionally contain an active amount of a-tocopherol, preferably, if the total amount of the a-tocopherol is e.g., 0.00001% by weight to 10% by weight, preferably 0.001% by weight to 5% by weight, in particular 0.005% by weight to 3% by weight, based on the total weight of the preparations, in order to provide cosmetic preparations.Advantageously, preparations according to the invention comprise formulations, may additionally contain an active amount of p-tocopherol, preferably, if the total amount of the p-tocopherol is e.g., 0.00001% by weight to 10% by weight, preferably 0.001% by weight to 5% by weight, in particular 0.005% by weight to 3% by weight, based on the total weight of the preparations, in order to provide cosmetic preparations.Advantageously, preparations according to the invention comprise formulations, may additionally contain an active amount of dimethyl methoxy chromanol, preferably, if the total amount of the dimethyl methoxy chromanol is e.g., 0.00001% by weight to 10% by weight, preferably 0.001% by weight to 5% by weight, in particular 0.005% by weight to 3% by weight, based on the total weight of the preparations, in order to provide cosmetic preparations.Advantageously, preparations according to the invention comprise formulations, may additionally contain an active amount of niacinamide, preferably, if the total amount of the niacinamide is e.g., 0.00001% by weight to 10% by weight, preferably 0.001% by weight to 5% by weight, in particular 0.005% by weight to 3% by weight, based on the total weight of the preparations, in order to provide cosmetic preparations.Niacinamide or nicotinamide is a form of vitamin B3found in food and used as a dietary supplement and medication. As a supplement, it is used by mouth to prevent and treat pellagra (niacin deficiency). Niacinamide is characterized by the structural formula as follows:In a still further aspect, the preparation may comprise less than about 1 .5% by weight of the one or more hydrocolloids, e.g., not more than about 1 .0% by weight of the one or more hydrocolloids and / or at least about 0.1% by weight of the one or more hydrocolloids, based on the total weight of the preparation.In another aspect of the preparation, the one or more hydrocolloids may comprise one or more of a) organic, fully synthetic compounds of polyacrylic acids, b) copolymers and crosspolymers of polyacrylic acid derivatives c) ammonium dimethyltauramide / vinylformamide copolymer d) copolymers / crosspolymers comprising acryloyldimethyltaurate e) hydrophilic gums and hydrophilic derivatives thereof f) cellulose, cellulose derivatives and microcrystalline cellulose.In another aspect, the one or more hydrocolloids may comprise one or more polyacrylates selected from carbopols of types 980, 981 , 1382, 2984 and 5984 and carbomer ULTREZ.In another aspect, the one or more hydrocolloids may comprise one or more of apolymethacrylate, an acrylate copolymer, an alkylacrylate copolymer, a polyacrylamide, an alkylacrylate crosspolymer, an acrylonitrogen copolymer and a polyacryloyldimethyltauramide.In another aspect, the one or more hydrocolloids may comprise one or more of agar agar, alginic acid, carrageen, gelatin, gum arabic, pectin and tragacanth and / or one or more of guar gum, locust bean flour, xanthan gum, polyvinyl alcohol, polyvinylpyrrolidone, propyleneglycol alginate and starch.In yet another aspect, the one or more hydrocolloids may comprise an alkyl-modified cellulose derivative and / or an alkylhydroxycellulose, for example, at least one of methylcellulose, hydroxypropylmethylcellulose and hydroxyethylcellulose.In yet another aspect, the preparation may comprise at least about 0.1% and / or not more than about 1 .0% by weight of the one or more hydrocolloids.In a still further aspect, the one or more hydrocolloids may comprise carbomer LILTREZ and / or at least one of agar agar, alginic acid, carrageen, gelatin, gum arabic, pectin and tragacanth and / or at least one of guar gum, locust bean flour, xanthan gum, gellan gum polyvinyl alcohol, polyvinylpyrrolidone, propyleneglycol alginate and starch and / or at least one of methylcellulose, hydroxypropylmethylcellulose and hydroxyethylcellulose.Advantageous alkylamidothiazoles in the context of the present invention are substances of the general formula :in which R1 , R2, X and Y can be different, partly identical or completely identical and, independently of one another, can mean:R1=-C1 -C24-alkyl (linear and branched), -C1 -C24-alkenyl (linear and branched), -C1 -C8- cycloalkyl, -C1-C8-cycloalkyl-alkylhydroxy, -C1 -C24-alkylhydroxy (linear and branched), -C1 -C24- alkylamine (linear and branched), -C1 -C24-alkylaryl (linear and branched), -C1 - C24-alkylaryl-alkyl-hydroxy (linear and branched), -C1 -C24-alkylheteroaryl (linear and branched), -C1 -C24-alkyl-O-C1 -C24-alkyl (linear and branched), -C1 -C24 alkyl-morpholino, -C1 -C24 alkyl-piperidino, -C1 -C24 alkyl-piperazino, -C1 -C24 alkyl-piperazino-N-alkyl,R2=H, -C1 -C24-alkyl (linear and branched), -C1 -C24-alkenyl (linear and branched), -C1 - C8-cycloalkyl, -C1 -C24-hydroxyalkyl (linear and branched), -C1 -C24-alkylaryl (linear and branched), -C1 -C24-alkylheteroaryl (linear and branched),X=-H, -C1 -C24-alkyl (linear and branched), -C1 -C24-alkenyl (linear and branched), -C1 -C8- cycloalkyl, -C1 -C24-aryl (optionally mono- or polysubstituted with -OH, -F, -Cl, -Br, -I, -OMe, -NH2, -CN), -C1 -C24-heteroaryl (optionally mono- or polysubstituted with -OH, -F, -Cl, -Br, - I, -OMe, -NH2, -CN), -C1 -C24-alkylaryl (linear and branched), -C1 -C24-alkylheteroaryl (linear and branched), -aryl (optionally mono- or polysubstituted with -OH, -F, -Cl, -Br, -I, - OMe, -NH2, -CN), -phenyl, -2,4-dihydroxyphenyl, -2,3-dihydroxyphenyl, -2,4- dimethoxyphenyl, -2,3-dimethoxyphenyl,Y=H, -C1 -C24-alkyl (linear and branched), -C1 -C24-alkenyl (linear and branched), -C1 -C8- cycloalkyl, -C1 -C24-aryl, -C1 -C24-heteroaryl, -C1 -C24-alkylaryl (linear and branched), -C1 - C24-alkylheteroaryl (linear and branched), -aryl, -phenyl, -2,4-dihydroxyphenyl, -2,3- dihydroxyphenyl, -2,4-dimethoxyphenyl, -2,3-dimethoxyphenyl, -COO-alkyl, -COO-alkenyl, - COO-cycloalkyl, -COO-aryl, -COO-heteroaryl, and X, Y can optionally also=condensed aromatic, where X and Y can form with one another aromatic or aliphatic homo- or heterocyclic ring systems with up to n ring-forming atoms, and where the number n can assume values from 5 to 8, and the respective ring systems can in turn be substituted with up to n-1 alkyl groups, hydroxyl groups, carboxyl groups, amino groups, nitrile functions, sulfur-containing substituents, ester groups and / or ether groups.Said thiazoles can either be in the form of the free base or the salt: e.g., fluoride, chloride, bromide, iodide, sulfate, carbonate, ascorbate, acetate or phosphate, in particular in the form of halogen salts, such as e.g., chloride and bromide.Furthermore, there is an advantageous realization of the present invention in cosmetic or dermatological preparations with an effective content of one or more aforementioned alkylamidothiazoles.Also in accordance with the invention is the use of the aforementioned alkylamidothiazolesfor the treatment and / or prophylaxis of undesired skin pigmentation.Here, treatment and / or prophylaxis of undesired skin pigmentation can be both in the cosmetic sphere and in the pharmaceutical sphere.In this connection, the pharmaceutical (or dermatological) treatment is primarily understood for diseased skin conditions, whereas the cosmetic treatment and / or prophylaxis of undesired skin pigmentation primarily relates to healthy skin.Advantageously, X is selected from the group of substituted phenyls, in which case the substituents (Z) can be selected from the group -H, -OH, -F, -Cl, -Br, -I, -OMe, -NH2, -CN, acetyl and can be identical or different.Particularly advantageously, X is selected from the group of phenyl groups substituted with one or more hydroxy groups, in which case the substituent (Z) can be selected from the group -H, -OH, -F, -Cl, -Br, -I, -OMe, -NH2, -CN, acetyl, and preference is given to the following generic structure in which Y, R1 and R2 can have the properties defined above.

[0034] Particularly advantageous compounds are those in whichY=HR1=-C1 -C24-alkyl (linear and branched), -C1 -C24-alkenyl (linear and branched), -C1 -C8- cycloalkyl, -C1-C8-cycloalkyl-alkylhydroxy, -C1 -C24 alkylhydroxy (linear and branched), -C1 -C24 alkylamine (linear and branched), -C1 -C24-alkylaryl (linear and branched), -C1 - C24-alkylaryl-alkyl-hydroxy (linear and branched), -C1 -C24-alkylheteroaryl (linear and branched), -C1 -C24-alkyl-O-C1 -C24-alkyl (linear and branched), -C1 -C24-alkyl-morpholino, -C1 -C24 alkyl-piperidino, -C1 -C24 alkyl-piperazino, -C1 -C24 alkyl-piperazino-N-alkyl, R2=H, -C1 -C24-alkyl (linear and branched), Z=-H, -OH, -F, -Cl, -Br, -I, -OMe, -NH2, -CN, acetyl.Particular preference is given to those compounds in which Image available on "Original document"Y=HR1 =-C1 -C24-alkyl (linear and branched), -C1 -C24-alkenyl (linear and branched), -C1 -C8- cycloalkyl, -C1 -C8-cycloalkyl-alkylhydroxy, -C1 -C24-alkylhydroxy (linear and branched), - C1 -C24 alkylamine (linear and branched), -C1 -C24-alkylaryl (linear and branched), -C1 - C24-alkyl-aryl-alkyl-hydroxy (linear and branched), -C1 -C24-alkylheteroaryl (linear and branched), -C1 -C24-alkyl-O-C1 -C24-alkyl (linear and branched), -C1 -C24 alkyl-morpholino, -C1 -C24 alkyl-piperidino, -C1 -C24 alkyl-piperazino, -C1 -C24 alkyl-piperazino-N-alkyl, R2=H.The following compounds are most preferred ones within the scope of the present invention:W-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)pivalamideN-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide (i.e., isobutylamido thiazolyl resorcinol)Ar-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)butyramideAr-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-4-(hydroxymethyl)cyclohexanecarboxamideCosmetic or dermatological preparations with a content of alkylamidothiazoles and their use for the treatment and / or prophylaxis of undesired skin pigmentation are likewise advantageous embodiments of the present invention.It is particularly advantageous if such preparations comprise 0.000001 to 10% by weight, in particular 0.0001 to 3% by weight, very particularly 0.001 to 1% by weight, of one or more of the alkylamidothiazoles used according to the invention, based on the total weight of the preparation.Particularly advantageous embodiments of the present invention encompass cosmetic or dermatological preparations which are exempt of trans-4-t-butyl-cyclohexanol which is characterized by the structural formulaCosmetic and dermatological preparations according to the invention can be in various forms. Thus, they can be e.g., a solution, an anhydrous preparation, an emulsion or microemulsion of the water-in-oil (W / O) type or of the oil-in-water (O / W) type, a multiple emulsions, for example of the water-in-oil-in-water (W / O / W) type, a gel, a solid stick, a balm or else an aerosol. It is also advantageous according to the invention to administer the substances used according to the invention and / or their derivatives in encapsulated form, e.g. in collagen matrices and other customary encapsulation materials, e.g. as cellulose encapsulations, in gelatin or liposomally encapsulated.It is also possible and advantageous in the context of the present invention to add the substances used according to the invention and / or their derivatives in aqueous systems or surfactant preparations for cleaning the skin and the hair.The cosmetic and dermatological preparations according to the invention can comprise cosmetic auxiliaries as are customarily used in such preparations, e.g., preservatives, bactericides, perfumes, substances for preventing foaming, dyes, pigments which have a coloring effect, thickeners, surface-active substances, emulsifiers, softening, moisturizing and / or humectant substances, fats, oils, waxes or other customary constituents of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.The lipid phase can advantageously be selected from the following substance group: mineral oils, mineral waxes oils, such as triglycerides of capric acid or of caprylic acid, also natural oils such as e.g. castor oil; fats, waxes and other natural and synthetic fatty bodies, preferably esters of fatty acids with alcohols of low carbon number, e.g. with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low carbon number or with fatty acids; alkyl benzoates; silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixtures thereof.The oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions within the context of the present invention is advantageously selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of chain length from 3 to 30 C atoms and saturated and / or unsaturated, branched and / or unbranched alcohols of chain length from 3 to 30 C atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols of chain length from 3 to 30 C atoms. Such ester oils can then advantageously be selected from the group of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyldodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate, and synthetic, semisynthetic and natural mixtures of such esters, e.g., jojoba oil.The aqueous phase of the preparations according to the invention optionally advantageously comprises humectants such as e.g., propylene glycol, panthenol or hyaluronic acid, and in particular one or more thickeners which can advantageously be selected from the group of silicon dioxide, aluminum silicates,hydroxypropylmethylcellulose, particularly advantageously a polyacrylate such as, for example, carbopol grade 980, in each case individually or in combination.In particular, mixtures of the aforementioned solvents are used. In the case of alcoholic solvents, water can be a further constituent.Emulsions according to the invention are advantageous and comprise e.g., the specified fats, oils, waxes and other fatty bodies, as well as water and an emulsifier, as is customarily used for such a type of formulation.Gels according to the invention usually comprise alcohols of low carbon number, e.g., ethanol, propylene glycol, and water or an aforementioned oil in the presence of a thickener which, in the case of oily-alcoholic gels, is preferably silicon dioxide or an aluminum silicate, and in the case of aqueous-alcoholic or alcoholic gels is preferably a polyacrylate.Suitable propellants for preparations according to the invention that can be sprayed from aerosol containers are the customary known readily volatile, liquefied propellants, for example hydrocarbons (propane, butane, isobutane), which can be used on their own or in a mixture with one another. Compressed air is also to be used advantageously.Advantageously, preparations according to the invention can furthermore comprise filter substances which absorb UV radiation in the UVB region, the total amount of the filter substances being e.g., 0.1% by weight to 30% by weight, preferably 0.5 to 10% by weight, in particular 1 .0 to 6.0% by weight, based on the total weight of the preparations, in order to provide cosmetic preparations which protect the hair and / or the skin from the entire range of ultraviolet radiation. They can also serve as sunscreens for the hair or the skin.Furthermore, preparations according to the invention can advantageously additionally comprise perfume substances which conceal the troublesome intrinsic odor of the remaining raw materials used, the total amount of the perfume ingredients being e.g., 0.001% by weight to 30% by weight, preferably 0.05 to 10% by weight, in particular 0.1 to 5.0% by weight, based on the total weight of the preparations, in order to provide cosmetic preparations.Very advantageous compositions according to the present invention contain: Isobutylamido Thiazolyl Resorcinol in amounts from 0.01 %~0.2% by weight; Niacinamide in amounts from 0.01 %~3% by weight;ferulic acid and / or one or more ferulic acid salts and / or one or more ferulic acid glycosides + Caprylic / Capric Triglyceride, in amounts from 0.01 %~0.15% by weight; Sodium Hyaluronate, Xanthan Gum, Gellan Gum in amounts from 0.01 %~0.2% by weight;PEG-40 Hydrogenated Castor Oil, in amounts from 0.01 %~5% by weight; and Alcohol, in amounts from 5% -20% by weight; based on the total weight of the preparations.ExamplesThe examples below are intended to illustrate the present invention without limiting it. Unless stated otherwise, all of the quantities, fractions and percentages stated are based on the weight and the total amount or on the total weight of the preparations. Since the color changes of the products are always very difficult to judge, it is, therefore, advantageous using a special instrument called Digi-Eye on the color change.The DigiEye is a computer-controlled digital camera system for measuring colour and capturing high-quality repeatable images. With the DigiEye system, it is possible to capture colorimetrically accurate images of 2- and 3D samples and save the images in the digital files. DigiEye provides Rd and colorimetric data from samples with an ultra-small area, irregular or curved surfaces. First, an image is captured by the calibrated digital camera; the colour measurement of the object image is then performed by the DigiEye software.For sili at 3M AECMC 17.79 13.36 5.7 3.63 3.82 10.27In our study, we use the AECMC for color change measurement. Normally, we will compare the sample under sili (sili means samples placed in north window light) which has been last for 3 months with the fresh samples, take photos for both of them, and let the digi-eye software to use AECMC to measure the 3 months color change. The smaller the AECMC is, the smaller color change is, which means the sample under sunlight still keeps more similar color as the fresh samples.

Claims

Claims1 . Active ingredient combinations of a) one or more alkylamidothiazoles, and b) ferulic acid and / or one or more ferulic acid salts and / or one or more ferulic acid glycosides, c) in a cosmetic excipient.

2. Cosmetic preparations containing combinations according to claim 1.

3. Use of active ingredient combinations of b) ferulic acid and / or one or more ferulic acid salts and / or one or more ferulic acid glycosides, to prevent or reduce the deterioration of alkylamidothiazoles caused by oxidative processes and / or heat and / or UV-light in cosmetic preparations containing one or more alkylamidothiazoles.

4. Cosmetic preparations according to claim 2 or use according to claim 3, characterised in that the total amount of the one or more alkylamidothiazoles is 0.00001% by weight to 10% by weight, preferably 0.001% by weight to 5% by weight, in particular 0.005% by weight to 3% by weight, based on the total weight of the preparations.

5. Cosmetic preparations according to one of the preceding claims, characterized in that the total amount of the ferulic acid and / or one or more ferulic acid salts and / or one or more ferulic acid glycosides is 0.00001% by weight to 10% by weight, preferably 0.001% by weight to 5% by weight, in particular 0.005% by weight to 3% by weight, based on the total weight of the preparations.

6. Cosmetic preparations according to one of the preceding claims, characterized in that they additionally comprise niacinamide, the total amount of the niacinamide being 0.00001% by weight to 10% by weight, preferably 0.001% by weight to 5% by weight, in particular 0.005% by weight to 3% by weight, based on the total weight of the preparations.

7. Cosmetic preparations according to one of the preceding claims, characterized in that they additionally comprise a-tocopherol, the total amount of the a-tocopherol being 0.00001% by weight to 10% by weight, preferably 0.001% by weight to 5% by weight, in particular 0.005% by weight to 3% by weight, based on the total weight of the preparations.

8. Cosmetic preparations according to one of the preceding claims, characterized in that they additionally comprise p-tocopherol, the total amount of the p-tocopherol being 0.00001% by weight to 10% by weight, preferably 0.001% by weight to 5% by weight, in particular 0.005% by weight to 3% by weight, based on the total weight of the preparations.

9. Cosmetic preparations according to one of the preceding claims, characterized in that they comprise less than about 1 .5% by weight of the one or more hydrocolloids, e.g., not more than about 1 .0% by weight of the one or more hydrocolloids and / or at least about 0.1% by weight of the one or more hydrocolloids, based on the total weight of the preparation.

10. Active ingredient combinations or cosmetic preparations according to one of the preceding claims, characterized in that the alkylamidothiazole or the alkylamidothiazoles is or are selected from the group consisting of the following substances:jV-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)pivalamideA^-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramidejV-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)butyramideAr-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)acetamideA / -(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-4-(hydroxymethyl)cyclohexanecarboxamide11 . Active ingredient combinations or cosmetic preparations according to one of the preceding claims, characterized in that, they are exempt of trans-4-t-butyl-cyclohexanol.

12. Active ingredient combinations according to claim 1 , additionally comprising tocopherol.

13. Active ingredient combinations according to claim 12, wherein the tocopherol is a- tocopherol and / or p-tocopherol.

14. Use according to claim 3, wherein active ingredient combinations additionally comprise tocopherol.

15. Use according to claim 14, wherein the tocopherol is a-tocopherol and / or p-tocopherol.

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