Assemblies comprising multiple ion guides, and extraction tools therefor

A removable modular ion guide sub-assembly with alignment elements addresses the challenge of maintaining mass spectrometers, enabling users to perform self-service maintenance and reduce downtime.

WO2025253239A1 Publication Date: 2025-12-11DH TECH DEVMENT PTE
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Patent Information

Application Number
PCT/IB2025/055530
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-06-05
Filing Date
2025-05-28
Publication Date
2025-12-11

AI Technical Summary

Technical Problem

Conventional mass spectrometers face challenges in self-service maintenance due to complex internal components, leading to impractical user inspections and prolonged instrument downtime, especially when internal ion guide components become contaminated.

Method used

A removable modular ion guide sub-assembly with alignment elements allows for blind insertion and extraction, maintaining structural integrity, enabling users to perform maintenance without disassembling the mass spectrometer.

Benefits of technology

Enables users to troubleshoot and maintain mass spectrometers independently, reducing downtime and improving operational efficiency by allowing easy access and cleaning of ion guide components.

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Abstract

Disclosed are methods, systems, apparatus, devices, and other implementations, that include a mass spectrometry (MS) system including a casing defining a cavity, a removable ion guide sub-assembly configured to be disposed within the cavity and including at least two mechanically coupled ion guides each defining a separate chamber at different pressures when engaged with the casing, with the removable ion guide sub-assembly including one or more insertion alignment elements to rotationally and / or angularly align the ion guide assembly for insertion into the cavity, and one or more receiving alignment elements disposed in the cavity and configured to receive a corresponding one of the one or more insertion alignment elements. The ion guide sub-assembly is configured to be axially removable from the casing with the at least two ion guides remaining mechanically coupled to each other and retaining the casing upon removal of the ion-guide sub-assembly from the casing.
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