Selective deodorant comprising methylheptylglycerin

Abstract

A selective deodorant.

Description

[0001] Beiersdorf AG

[0002] Selective deodorant with methylheptylglycerin

[0003] The invention relates to a deodorant that is selectively effective against Corynebacterium jeikeium (C. jeikeium).

[0004] Cosmetic products generally serve not only to make one look beautiful and attractive, but also contribute significantly to increased self-esteem and well-being. Accordingly, a wide variety of cosmetic products are used for daily cleansing and skin care.

[0005] One category of cosmetic products is deodorants and antiperspirants, which are applied under the arms to prevent unpleasant odors and perspiration. The cause of unpleasant odors is the decomposition of sweat, which is itself odorless, by bacteria. Among the byproducts of this decomposition are fatty acid residues, which characterize the typical, familiar smell of sweat. Although deodorants and antiperspirants are applied to the same area of ​​skin and pursue the same goal, they differ in their technical mechanisms of action.

[0006] Antiperspirants contain antiperspirant active ingredients that serve to inhibit and reduce perspiration. Antiperspirant active ingredients containing aluminum can clog the sweat glands.

[0007] Deodorants, on the other hand, are characterized by the fact that they do not impede the flow of perspiration. Instead, deodorants are understood to be products containing special antimicrobial agents that reduce the growth of bacteria. Consequently, the decomposition of odorless sweat is reduced, resulting in fewer unpleasant odors.

[0008] Conventionally, antiperspirants and deodorants are applied to the skin either using a roll-on applicator or as a spray. Sprays include both aerosol sprays powered by a propellant and pump sprays operated by a hand pump. Depending on the application method, the cosmetic preparations vary significantly in their composition.

[0009] A disadvantage of well-known deodorants is that the active ingredients used, as well as the formulation itself, have a general antimicrobial effect, thus reducing the overall population of bacteria on the skin. For example, the frequently used active ingredients ethylhexylglycerin or octenidine HCl have a bactericidal effect against both Corynebacterium jeikeium and Staphylococcus epidermidis.

[0010] Staphylococcus epidermidis is a gram-positive bacterium of the genus Staphylococcus, found on human skin and mucous membranes. In healthy individuals, S. epidermidis is not pathogenic. The presence of S. epidermidis on the skin protects it from colonization by pathogenic microorganisms. Furthermore, according to recent studies, S. epidermidis is not primarily involved in the development of body odor, so its inhibition represents an unnecessary intervention in the composition of the skin microbiome.

[0011] The commercial products Rossmann Isana Med 24H Ultra Sensitive Deo Roll-On (Mintel GNPD registration number 10798513) and DM Balea 24h Deodorant Roll-On (Mintel GNPD registration number 10577376) use the active ingredients.

[0012] Furthermore, such deodorants are known from EP3236917A1.

[0013] Consequently, the use of these deodorants is often associated with damage to the skin biome. In particular, the population of Staphylococcus epidermidis is unnecessarily reduced.

[0014] One object of the present invention was therefore to provide skin microbiome-friendly deodorants effective against sweat odor, which, among other things, act selectively against Corynebacterium jeikeium and do not kill Staphylococcus epidermidis or only partially reduce its population on the skin.

[0015] Surprisingly, the requirements could be met by the invention. One aspect of the present invention is the use of methylheptylglycerin for the selective reduction of the number of Corynebacterium jeikeium bacteria on human skin.

[0016] Another object of the invention is the use of methylheptylglycerin in a cosmetic deodorant and / or antiperspirant for the selective reduction of the number of bacteria of the bacterium Corynebacterium jeikeium on human skin, wherein the deodorant and / or antiperspirant is applied to the skin.

[0017] The invention also relates to the use of a cosmetic deodorant and / or antiperspirant comprising methylheptylglycerin for the selective reduction of the number of bacteria of the bacterium Corynebacterium jeikeium on human skin, wherein the deodorant and / or antiperspirant is applied to the skin.

[0018] In this context, the term "selective" means that there is a reduction / death of the population of the bacteria mentioned, while at the same time the number of skin-friendly bacteria, in particular the number of Staphylococcus epidermidis, is only limited or not reduced.

[0019] By definition, skin-friendly bacteria are Propionibacteria (except P. acnes), Proteobacteria, Corynebacteria and Staphylococcus aureus (except S. aureus and those that contribute to the formation of body odor).

[0020] In particular, the invention relates to the use of methylheptylglycerin to reduce the number of bacteria of the bacterium Corynebacterium jeikeium on human skin, wherein the number of bacteria of the bacterium Staphylococcus epidermidis is only partially or not reduced.

[0021] A further advantageous aspect of the invention is the use of methylheptylglycerin in a cosmetic deodorant and / or antiperspirant preparation for the selective reduction of the number of bacteria of the bacterium Corynebacterium jeikeium on human skin, wherein the deodorant and / or antiperspirant preparation is applied to the skin and wherein the number of bacteria of the bacterium Staphylococcus epidermidis is only partially or not at all reduced.

[0022] The invention also relates to the use of a cosmetic deodorant and / or antiperspirant preparation comprising methylheptylglycerin for the selective reduction of the number of bacteria of the bacterium Corynebacterium jeikeium on human skin, wherein the deodorant and / or antiperspirant is applied to the skin and wherein the number of bacteria of the bacterium Staphylococcus epidermidis is only partially or not reduced.

[0023] In the preceding paragraphs, the term "limited" is used. For the purposes of this disclosure, this term is to be understood as meaning that the population of the bacteria mentioned is not reduced by more than 1 log unit when using the invention, compared to an untreated control. The data refers to a measurement by suspension test, as described below, under standard conditions.

[0024] Last but not least, an object of the invention is a cosmetic deodorant and / or antiperspirant preparation comprising methylheptylglycerin.

[0025] The invention also relates to a non-therapeutic method for selectively reducing the number of bacteria of the bacterium Corynebacterium jeikeium on human skin by topical application of a deodorant and / or antiperspirant preparation comprising methylheptylglycerin.

[0026] It is known that substances present on the skin, such as skin lipids and proteins, can inhibit the activity of potential deodorants, preventing them from having a deodorizing effect. Therefore, it is not clear whether, for example, antimicrobial substances automatically have a deodorizing effect. A challenge thus lies in identifying active ingredients that, in addition to being skin-friendly, primarily have a deodorizing effect and can be used as deodorants. Usable in this context means that skin irritation or other adverse effects are avoided.

[0027] It was surprisingly discovered that the use of methylheptylglycerin in deodorant formulations, particularly when applied under the armpits, reduces the formation of typical body odor. Consequently, methylheptylglycerin has a surprisingly effective deodorizing effect. This was confirmed in a sniff test (see further details below).

[0028] Consequently, the use of is also an object of the invention.

[0029] Methylheptylglycerin is used as a deodorizing agent, particularly in cosmetic preparations applied topically to the skin. It is especially commonly applied to the underarm skin.

[0030] Unless otherwise stated, all weight percentages (wt%) specified below are based on the total weight of the preparation according to the invention, which in this case is a deodorant preparation and / or an antiperspirant preparation. Where ratios of certain components are disclosed in the following description, these ratios refer, unless otherwise stated, to weight ratios of the components.

[0031] Unless otherwise stated, all tests and measurements were carried out under "normal conditions". The term "normal conditions" refers to 20°C, 1013 hPa, and a relative humidity of 50%.

[0032] The advantage of the invention lies in its high antimicrobial selectivity. The compositions specifically lead to a significant reduction in the cell count of Corynebacterium jeikeium. Simultaneously, the compositions have no or only a minimal inhibitory effect on S. epidermidis, whose numbers on the skin are not significantly reduced. As explained in the examples described below, when applied under the armpit to human skin, the invention leads to a reduction of more than 3 log units in the population of Corynebacterium jeikeium, while S. epidermidis showed no significant reduction in bacterial count, in each case compared to an untreated control. The data refer to a suspension test performed as described below.

[0033] It is preferred that the number of Corynebacterium jeikeium in a specific skin area decreases by at least 1 log, at least 2 log, at least 3 log, at least 4 log, or at least 5 log after application of the composition according to the invention, compared to the cell count in the relevant skin area before application of the composition. It is further preferred that the number of S. epidermidis in this skin area simultaneously decreases by at most 1 log, at most 1.5 log, or less, compared to the cell count in the relevant skin area before application of the composition. Whenever the expression "after application" or an equivalent temporal term is used in this disclosure, this always refers to a period of up to 24 hours, in particular 3 hours, after application.

[0034] The term "skin" refers exclusively to human skin.

[0035] The preparations of the invention are advantageously characterized in that methylheptylglycerin is contained in proportions of 0.01 to 10 wt.%, preferably 0.05 to 2 wt.% and particularly preferably 0.1 to 1 wt.%, in each case based on the total weight of the preparation.

[0036] The preparations of the present invention can be in various forms. Preferred preparation forms include, for example, a solution, a suspension, a water-in-oil (W / O) or oil-in-water (O / W) emulsion, a multiple emulsion (e.g., water-in-oil-in-water (W / O / W) or oil-in-water-in-oil (O / W / O)), a hydrodispersion, a lipodispersion, or an aerosol. Furthermore, the preparations can also be in solid stick form, in which the stick material is transferred to the skin by abrasion.

[0037] In an advantageous embodiment, the preparations according to the invention are emulsions which, in addition to methylheptylglycerin, contain further substances such as fats, oils, waxes and / or other fatty substances, as well as water and one or more emulsifiers, such as are commonly used for this type of formulation. Such emulsions can advantageously be formulated as a cream or lotion.

[0038] In a further advantageous embodiment, the preparations according to the invention are in the form of an alcoholic solution, preferably an ethanolic solution. In this embodiment, the preparations advantageously comprise an alcohol content, preferably an ethanol content, of 30% to 99% by weight, based on the total weight of the preparation. Due to their low viscosity, these preparations are particularly suitable for use in a pump atomizer that is operated without propellant gas.

[0039] Further embodiments include cosmetic products comprising a pressure vessel with a dispensing valve, a cosmetic preparation containing methylheptylglycerin located in the pressure vessel, and a propellant, in particular propane, butane, and / or nitrogen, which are also contained in the pressure vessel. The amount of propellant is selected such that, upon opening the dispensing valve, the cosmetic preparation is dispensed along with the propellant. In this way, the preparation becomes sprayable and can be applied to the skin. For such products, alcoholic, anhydrous preparations or emulsions are advantageously used as the preparation. The mixing ratio of the alcoholic solution, anhydrous preparation, or emulsion with the propellant is preferably in the range of 10 to 40 vol.%, in particular 15 vol.%, and 60 to 90 vol.%, in particular 85 vol.%.% propellant gas, to be selected, the values ​​referring to the total volume of the pressure vessel. Advantageously, the ratio is in the range of 15 vol.% preparation to 85 vol.% propellant gas, or 30 vol.% to 70 vol.%, or particularly 60 vol.% preparation to 40 vol.% propellant gas. According to the invention, these propellant-containing preparations then contain methylheptylglycerin, advantageously in a proportion of 0.01 to 10 wt.%, based on the total mass of the preparation without propellant gas.

[0040] Antimicrobial agents do not inherently have a deodorizing effect. A deodorizing effect only occurs when the active ingredient reduces typical body odor after application to the skin. For example, triclosan is a known antimicrobial agent. It has been found that triclosan shows slight efficacy after 12 hours in a sniff test, but no efficacy after 24 hours. The sniff test is used to determine the deodorizing efficacy of cosmetic formulations, typically lasting 48 hours after a single application. The test product is applied and its efficacy is measured in the consumer-relevant area: the underarm. The target parameter is the odor intensity of underarm sweat. Therefore, knowledge of general antimicrobial efficacy does not automatically imply good deodorizing efficacy.

[0041] Surprisingly, preparations according to the invention containing methylheptylglycerin show very good and significant effects in the in vivo sniff test against an untreated control.

[0042] An aerosol spray preparation according to example 1 was tested without the addition of perfume.

[0043] Example 1

[0044] Ethanol 98.5 wt.%

[0045] Octyldodecanol 1% by weight Methylheptylglycerol 0.5% by weight

[0046] This preparation was filled with a 30:70 ratio of propellant gas (propane / butane / isobutane) (by volume%).

[0047] Prerequisites and limitations

[0048] During the 7-day washout phase, the test subjects had to use only a special, unscented standard soap (product: Baktolin basic pure pH 5.5, Bode).

[0049] For 7 days before the start of the study and throughout the entire study period, the participants had to refrain from the following:

[0050] ■ Use of deodorants and antiperspirants in the armpits, as well as cosmetic products such as creams or perfumes

[0051] ■ Shaving the armpits

[0052] 24 hours before the scheduled assessment, the test subjects had to refrain from the following:

[0053] ■ Eat very spicy food

[0054] ■ Visits to saunas and swimming pools, as well as intensive sports

[0055] The use of soaps and deodorizing products in the armpit was prohibited between individual examinations.

[0056] Product treatments

[0057] First, the subjects washed their armpits for 30 seconds with unscented standard soap (product: Baktolin basic pure pH 5.5, Bode). Then, an examiner applied the test product three times to the respective area, using a quantity of approximately 1000-1500 mg (3 x 2-second sprays) per application on 3 consecutive days. One armpit was treated at a time, while the other remained untreated.

[0058] Methodology: All equipment and instruments required for conducting the study were prepared and operated by trained and experienced personnel. The intensity of the odor produced in the armpit was determined using a sniff test method, i.e., an olfactory test for sweat odor intensity (pads – indirect sniffing) by six independent experts = sniffer panel.

[0059] After the final application, the participants were not allowed to wash. Twenty hours later, unscented panty liners were placed under the participants' armpits. Four hours later, these were removed and used for a sniff test conducted by experts.

[0060] Interpretation: Expert rating scale (SNI & ESN):

[0061] 0: no sweat odor

[0062] 1: very slight sweat odor

[0063] 2: slight sweat odor

[0064] 3: distinct sweat odor

[0065] 4: strong sweat odor

[0066] 5: extreme sweat odor

[0067] In this procedure, glasses containing panty liners are placed in pairs, one for the left (L) and one for the right (R). Glasses R and L of a test subject are opened and sniffed sequentially, and only then is an assessment made for each sample. A coded test sample (coding according to Wl 7 MAT 100) is tested in a contralateral comparison against the untreated control.

[0068] The sniff test results are shown in Table 1.

[0069] Advantageous preparations of the invention are further characterized in that they contain an antiperspirant active ingredient. It is particularly advantageous if the antiperspirant active ingredient is selected from the group of aluminum salts with the formula [Al2(OH)2]2. m Cln], where m+n=6.

[0070] Examples of aluminium salts according to the invention are: - aluminium salts such as aluminium chloride AlCh, aluminium sulfate Ah(SO4)3

[0071] - Aluminum chlorides of the empirical molecular formula [Al2(OH) m Cl n ], where m+n=6

[0072] - Aluminum chlorohydrate [Al2(OH)sCI] x H2O (ACH)

[0073] Standard Al complexes: Locron P (Clariant), Locron L (Clariant), Micro-Dry (Reheis), ACH-331 (Summit), Aloxicoll PF 40 (Giulini)

[0074] - Activated Al complexes: Reach 501 (Reheis), AACH-324 (Summit), AACH-7171 (Summit), Aloxicoll P (Giulini), Aloxicoll SD100

[0075] - Aluminum sesquichlorohydrate [Ah OH sCh.s] x H2O

[0076] Standard Al complexes: Aluminum Sesquichlorohydrate (Reheis), AACH-308 (Summit)

[0077] - Activated Al complexes: Reach 301 (Reheis)

[0078] - Aluminum dichlorohydrate [Ah OH^Ch] x H2O

[0079] Furthermore, it is advantageous if at least one aluminum-zirconium salt is included as the antiperspirant active ingredient. Advantageously selected from the group are aluminum / zirconium trichlorohydrex glycine ([Al₄Zr(OH)₃Ch] x H₂O x Gly), aluminum / zirconium tetrachlorohydrex glycine ([Al₄Zr(OH)₂Cl₄] x H₂O x Gly), aluminum / zirconium pentachlorohydrex glycine ([Al₄Zr OH⁻sCl₃] x H₂O x Gly), aluminum / zirconium octachlorohydrex glycine ([Al₄Zr(OH)₂Cl₈] x H₂O x Gly), and the glycine-free aluminum / zirconium salts. Aluminum / zirconium tetrachlorohydrex glycine is particularly preferred.

[0080] It is particularly advantageous if the aluminum-containing antiperspirant active ingredient is aluminum chlorohydrate, aluminum sesquichlorohydrate and / or aluminum / zirconium tetrachlorohydrex glycine, with aluminum chlorohydrate being the most preferred.

[0081] Advantageously, the total proportion of aluminum-containing antiperspirant active ingredients is from 1 wt.% to 30 wt.%, preferably from 2 wt.% to 25 wt.% and particularly preferably from 5 wt.% to 22 wt.%, based on the total weight of the preparation.

[0082] It is particularly advantageous if the proportion of aluminium chlorohydrate is from 1 wt.% to 30 wt.%, preferably from 2 wt.% to 25 wt.% and especially preferably from 5 wt.% to 22 wt.%, based on the total weight of the preparation.

[0083] Other advantageous embodiments of the invention are characterized in that they do not contain any aluminum-containing antiperspirant active ingredients as described and listed above. Methylheptylglycerin can advantageously be used in preparations with other antibacterial active ingredients. Advantageous antibacterial active ingredients are selected from the list of epsilon polylysines, caprylyl glycol, potassium sorbate, and / or butyloctanoic acid. Other advantageous embodiments are characterized in that one, several, or all of these components are not included.

[0084] It is also advantageous if the preparations do not contain any other antibacterial agents.

[0085] Furthermore, it is advantageous if the preparation additionally contains at least one or more perfume substances that are liquid under normal conditions. Advantageously selected perfume ingredients are chosen from essential oils, geraniol, geranyl acetate, linalool, linalyl acetate, tetrahydrolinalool, citronellol, citronellyl acetate, dihydromyrcenol, dihydromyrcenyl acetate, tetrahydromyrcenol, terpineol, terpinyl acetate, nopol, nopyl acetate, 2-phenyl benzyl alcohol, benzyl acetate, benzyl salicylate, benzyl benzoate, styrallyl acetate, amyl salicylate, dimethylbenzylcarbinol, trichloromethylphenylcarbinyl acetate, p-tert-butylcyclohexyl acetate, isononyl acetate, vetiveryl acetate, alpha-hexylcinamaldehyde, 2-methyl-3-(p-tert-butylphenyl)propanol, 2-methyl-3-(p-isopropylphenyl)propanal, 3-(p-tert--Butylphenyl) propanal, tricyclodecenyl acetate, tricyclodecenyl propionate, 4-(4-hydroxy-4-methylpentyl)-3-cyclohexenecarbaldehyde, 4-(4-methyl-3-pentenyl)-3-cyclohexenecarbaldehyde, 4-acetoxy-3-pentyltetrahydropyran, methyldihydrojasmonate, 2 -heptylcyclopentanone, 3-methyl -2-pentylcyclopentanone, n-decanal, 9-decenol-1, phenoxyethyl isobutyrate, phenylacetaldehyde dimethyl acetal, phenylacetaldehyde diethyl acetal, geranonitrile, citronellonitrile, cedryl acetate, 3-isocamphylcyclohephane, ethine, heliotropin, coumarin, eugenol, Vanillin, Diphenyloxide, Hydroxycitronellal, Ionone, Methylionone, Isomethylionone, Iron, cis-3-hexenol and esters thereof, indane musk fragrances, tetralin musk fragrances, isochromane musk fragrances, macrocyclic ketones, macrolactone muscrown, macrolactone muscrown brassylate, and aromatic nitro musk fragrances. Other perfume components that may be included but are not expressly preferred are listed in Arctander, Perfume and Flavor Chemicals (Chemicals) Vol.I and II (1969) and Arctander, Perfume and Flavour Materials of Natural Origin (1960).

[0086] Advantageously, the proportion of perfume substances that are liquid under normal conditions is 0.001 to 2 wt.%, preferably 0.005 to 1.5 wt.% and particularly preferably 0.01 to 1.4 wt.% based on the total weight of the preparation. Other embodiments contain one or more of the perfume ingredients selected from the group Alpha-Isomethyl Ionone, Anise Alcohol, Benzyl Alcohol, Benzyl Benzoate, Benzyl Cinnamate, Benzyl Salicylate, Butylphenyl Methylpropional, Cinnamal, Cinnamyl Alcohol, Citral, Citronellol, Coumarin, D-Limonene, Eugenol, Linalool, Amyl Cinnamal, Amylcinnamyl Alcohol, Evernia Furfuracea (Treemoss) Extract, Evernia Prunastri (Oakmoss) Extract, Farnesol, Geraniol, Hexyl Cinnamal, Hydroxycitronellal, Isoeugenol, Methyl 2-Octynoate, Acetyl Cedrene, Alpha-Pinene, Alpha-Santalol and Betasantalol, Alpha-Terpinene, Anethole, Benzaldehyde, Beta-Caryophyllene, Beta-Pinene, Camphor, Cedrus Atlantica Extract, Cinnamomum Zeylanicum ExtractCitrus Sinensis / Aurantium Dulcis Extract, Cymbopogon Citratus I Schoenanthus Extract, Damascenone, Damascene Delta, Damascone-Cis-Alpha, Damascone-Cis-Beta, Dimethyl Benzyl Carbinyl Acetate (Dmbca), Eucalyptus Extract, Eucalyptus Extract, Eugenia Caryophyllus Extract, Eugenyl Acetate, Laurus Nobilis Extract, Lavandula Hybrida Extract, Lavandula Officinalis Extract, Linalyl Acetate, Mentha Piperita Extract, Menthol, Methyl Salicylate, Narcissus Extract, Otne, Pelargonium Graveolens Extract, Peru Balsam Extracts and Distillates (Myroxylon Baisamum Var Pereirae), Pinus Mugo Extract, Pinus Pumila Extract, Propylidene Phthalide, Terpinolene, Trimethyl- Benzenepropanol, Turpentine, Verbena Absolute (Lippia Citriodora Kunth.), 3-Methyl-5- (2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-en-2-ol, Alpha-Terpineol, Amyl Salicylate, Carvone, Cinnamomum Cassia Extract, Citrus Aurantium Amara Extract, Citrus Bergamia Extract, Citrus Limonum Extract, Geranyl Acetate, Hexadecanolactone, Hexamethylindanopyran,Isoeugenyl Acetate, Jasmine Absolute (Grandiflorum), Juniperus Virginiana Extract, Pogostemon Cablin Extract, Rose Extract, Salicylaldehyde, Santalum Album Extract, Sclareol, Terpineol, Vanillin und Ylang Ylang Extracts.,

[0087] Andere vorteilhafte Ausführungsformen sind frei von Parfüminhaltstoffen gewählt aus der Gruppe Alpha-Isomethyl Ionone, Anise Alcohol, Benzyl Alcohol, Benzyl Benzoate, Benzyl Cinnamate, Benzyl Salicylate, Butylphenyl Methylpropional, Cinnamal, Cinnamyl Alcohol, Citral, Citronellol, Coumarin, D-Limonene, Eugenol, Linalool, Amyl Cinnamal, Amylcinnamyl Alcohol, Evernia Furfuracea (Treemoss) Extract, Evernia Prunastri (Oakmoss) Extract, Farnesol, Geraniol, Hexyl Cinnamal, Hydroxycitronellal, Isoeugenol, Methyl 2-Octynoate, Acetyl Cedrene, Alpha-Pinene, Alpha-Santalol and Betasantalol, Alpha-Terpinene, Anethole, Benzaldehyde, Beta-Caryophyllene, Beta-Pinene, Camphor, Cedrus Atlantica Extract, Cinnamomum Zeylanicum Extract, Citrus Sinensis / Aurantium Dulcis Extract, Cymbopogon Citratus I Schoenanthus Extract, Damascenone, Damascene Delta, Damascone-Cis-Alpha, Damascone-Cis-Beta, Dimethyl Benzyl Carbinyl Acetate (Dmbca), Eucalyptus Extract, Eucalyptus Extract, Eugenia Caryophyllus Extract,Eugenyl Acetate, Laurus Nobilis Extract, Lavandula Hybrida Extract, Lavandula Officinalis Extract, Linalyl Acetate, Mentha Piperita Extract, Menthol, Methyl Salicylate, Narcissus Extract, Otne, Pelargonium Graveolens Extract, Peru Balsam Extracts and Distillates (Myroxylon Baisamum Var Pereirae), Pinus Mugo Extract, Pinus Pumila Extract, Propylidene Phthalide, Terpinolene, Trimethyl- Benzenepropanol, Turpentine, Verbena Absolute (Lippia Citriodora Kunth.), 3-Methyl-5- (2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-en-2-ol, Alpha-Terpineol, Amyl Salicylate, Carvone, Cinnamomum Cassia Extract, Citrus Aurantium Amara Extract, Citrus Bergamia Extract, Citrus Limonum Extract, Geranyl Acetate, Hexadecanolactone, Hexamethylindanopyran, Isoeugenyl Acetate, Jasmine Absolute (Grandiflorum), Juniperus Virginiana Extract, Pogostemon Cablin Extract, Rose Extract, Salicylaldehyde, Santalum Album Extract, Sclareol, Terpineol, Vanillin und Ylang Ylang Extracts.,

[0088] The preparations can be applied to the skin once or several times as part of therapeutic or non-therapeutic, cosmetic treatment. In one embodiment, the preparations according to the invention are formulated for daily application to the skin.

[0089] Examples:

[0090] The following examples are intended to illustrate this invention, without limiting the invention to these examples. The numerical values ​​in the examples are percentages by weight, based on the total weight of the preparations.

[0091] Two suspension tests were performed to demonstrate the selective antimicrobial efficacy.

[0092] Test:

[0093] The stock cultures of the respective bacteria in glycerol, prepared according to European standard EN 12353, are stored in a refrigerator at 5°C. The first passage is prepared from this liquid stock culture. Using a sterile, single-use inoculating loop, the culture is streaked onto appropriate agar plates (see culture conditions). This culture is then incubated (see culture conditions). A second passage is then prepared from this first passage by collecting a few colonies with a sterile inoculating loop and streaking them onto another, new agar plate. This second passage is then incubated for 24 hours at the appropriate temperature (see culture conditions). The resulting second passage can be used for the suspension test.

[0094] Using a sterile inoculation loop, a few colonies from the second passage are collected and added to 10 mL of medium (see culture conditions) in a baffle flask containing 5 g of 0.4 mm glass beads and vortexed (shaken) for 3 minutes. The approximate cell count per mL is then adjusted using optical density (OD). The optical density is determined using an Eppendorf photometer at 600 nm. To eliminate the influence of the medium, a blank is prepared using the medium. The culture is then measured using the "Sample" function. The resulting OD must be adjusted to a value of approximately 0.08 (±0.01) and then diluted 1:100 with medium. This dilution strategy yields an approximate cell count of 1 x 10⁻⁶. 5 .

[0095] 500 pL of formulation or raw material solution are placed in sterilized Eppendorf tubes. 500 pL of medium (see culture conditions) is used for the positive control. Each test always involves duplicate determination of the individual components. After adding 500 pL of the prepared culture suspension, the actual test begins. From this point on, 1:10 dilutions of all samples are prepared with neutralization medium (900 pL neutralization medium + 100 pL test sample) after 20 min, 60 min, and 180 min. Thorough mixing (vortexing) is essential. The diluted samples are plated onto agar plates (see culture conditions) using a spiral plater. After completion of the test, all agar plates are placed in the incubator for incubation and evaluated on the Countermat after incubation (see culture conditions).

[0096] The incubated plates are counted using a Countermat. A pre-existing template (SUS template) is used for the respective analyses in Excel. This template automatically generates the chart from the Countermat data and calculates the reduction factors. After duplicate testing, a report is generated that documents the test description, the chart, and the reduction factors.

[0097] The listed growing media and conditions were chosen according to the manufacturer's specifications to ensure the best possible growing conditions.

[0098] BHI medium

[0099] 37 g brain and heart broth per 1000 mL dehydrated water

[0100] AC Medium

[0101] 37 g brain and heart broth

[0102] 5g D(+)-Glucose

[0103] 1mL Tween 80 to 1000 mL VE-H2O

[0104] Neutralizing medium

[0105] 6g Tween 80

[0106] 6g saponin

[0107] 0.2g L-Histidine

[0108] 0.6g lecithin

[0109] 1g sodium thiosulfate

[0110] 0.2g peptone from casein, tryptically digested

[0111] 1.7g sodium chloride in 200 mL deionized water

[0112] Raw material formulation

[0113] 0.5% Methylheptylglycerin in water

[0114] Consequently, it has been shown that the use of methylheptylglycerin leads to a selective reduction of Corynebacterium jeikeium. Further example formulations:

[0115] Roll-ons

[0116] Aerosols:

[0117] The filling ratio (bulk:propellant) in volume % can be selected, among others, between 10:90, 15:85, 30:70, 50:50 or 60:40. Nitrogen, compressed air and a propane-butane mixture (2.7 bar; vol%) were used as propellant.

[0118] Pump spray / atomizer

[0119] pens

Claims

Claims 1. Use of methylheptylglycerin for the selective reduction of the number of bacteria of the bacterium Corynebacterium jeikeium on human skin.

2. Use of methylheptylglycerin in a cosmetic deodorant and / or antiperspirant preparation for the selective reduction of the number of bacteria of the bacterium Corynebacterium jeikeium on human skin, wherein the deodorant and / or antiperspirant is applied to the skin.

3. Use of a cosmetic deodorant and / or antiperspirant preparation containing methylheptylglycerin for the selective reduction of the number of bacteria of the bacterium Corynebacterium jeikeium on human skin, wherein the deodorant and / or antiperspirant is applied to the skin.

4. Use according to one of claims 2 or 3 characterized in that methylheptylglycerin is contained in proportions of 0.01 to 10 wt.%, preferably 0.05 to 2 wt.% and particularly preferably 0.1 to 1 wt.%, in each case based on the total weight of the preparation.

5. Use according to one of claims 2 to 4, characterized in that the preparation comprises ethanol.

6. Use according to claim 5 characterized in that the preparation comprises ethanol in a proportion of 30 wt.% to 99 wt.%, based on the total weight of the preparation.

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