Single-sample coagulation analysis device

Abstract

Disclosed in the present invention is a single-sample coagulation analysis device, comprising a test strip inflow and outflow assembly, an optical assembly, a plunger assembly, a sample adding and puncturing assembly and a control board; the optical assembly is movably arranged on the test strip inflow and outflow assembly, the plunger assembly and the sample adding and puncturing assembly are fixedly arranged on one side of the test strip inflow and outflow assembly, and the plunger assembly is pneumatically connected to the sample adding and puncturing assembly. The present invention can quickly test a plurality of coagulation items at one time, puncturing and sample-adding coagulation tests are successively performed at a plurality of test ends of a reagent test strip by means of a sample adding needle and a puncturing needle, then the test ends of the reagent test strip are tested by using an illumination panel and a signal detection panel, and each test end is provided with an illumination lamp and a signal receiver, thereby improving the test efficiency and test accuracy. The whole test process is fully automated, thereby significantly improving the accuracy and test speed thereof.

Description

Single-portion coagulation analysis device TECHNICAL FIELD

[0001] The present application relates to the technical field of coagulation detection, and particularly relates to a single-portion coagulation analysis device. BACKGROUND

[0002] Coagulation detection is used in medicine to evaluate blood clotting ability and plays an important role in diagnosing diseases. Generally, coagulation detection includes four-item coagulation detection, and main detection items are prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB). Through the above detection objects, whether a patient has a bleeding disease, a thrombotic disease or other diseases can be well judged. A specific detection method is to place a blood sample of the patient in a specific coagulation detection reagent, and a detection result is obtained according to a clotting time of the blood sample. The detection result is generally completed by a coagulation analysis instrument.

[0003] In the prior art, coagulation analysis instruments are used for detecting multiple portions of blood samples. An invention patent with the patent number 201822125316.X and the patent name coagulation analyzer detector discloses a detector including a detection plate, a plurality of V-shaped grooves are formed on one side surface of the detection plate, a detection hole, a plurality of sample heating holes and preheating holes are arranged on the detection plate at positions between the two V-shaped grooves, and a light emitting channel and a light receiving channel are arranged on two side surfaces of the V-shaped groove. The above technology can simultaneously detect multiple blood samples through optical detection, but the detection efficiency is low in the detection of single-portion blood samples, multiple coagulation items cannot be simultaneously detected, and the detection precision is not high enough. Therefore, a more reasonable coagulation analysis device is needed to solve the above technical problems. TECHNICAL PROBLEM

[0004] In view of the above technical problems that multiple coagulation items cannot be simultaneously detected, resulting in low detection efficiency and detection precision, the present application provides a single-portion coagulation analysis device. TECHNICAL SOLUTION

[0005] To achieve the above purpose, the present application provides a single-portion coagulation analysis device, which comprises a card strip in-out assembly, an optical assembly, a plunger assembly and a sample adding and piercing assembly. The optical assembly is movably arranged on the card strip in-out assembly. The plunger assembly and the sample adding and piercing assembly are fixedly arranged on one side of the optical assembly. The plunger assembly is pneumatically connected with the sample adding and piercing assembly. In operation, a reagent card strip is inserted into the optical assembly. The card strip in-out assembly drives the optical assembly to move to the sample adding and piercing assembly. The sample adding and piercing assembly pierces the reagent card strip. The plunger assembly controls the sample adding and piercing assembly to add a sample. The optical assembly detects coagulation of the reagent card strip.

[0006] As an improved scheme of the present application, the card strip access assembly comprises a base, a first sliding rail, a first driving motor, a first transmission shaft belt, the first driving motor is arranged at one end of the base, one end of the first transmission shaft belt is sleeved on the output shaft of the first driving motor, the other end of the base is provided with a first fixing seat, and the other end of the first transmission shaft belt is sleeved on the first fixing seat; the optical assembly is movably connected with the first sliding rail and fixedly connected with the first transmission shaft belt; the plunger assembly and the sample adding and piercing assembly are arranged on the base.

[0007] As an improved scheme of the present application, the optical assembly comprises a signal detection plate, an illumination plate and a first sliding piece, the signal detection plate and the illumination plate are oppositely arranged on the first sliding piece, and the signal detection plate and the illumination plate are spaced apart to form a mounting portion for clamping a reagent card strip; the first sliding piece is embedded on the first sliding rail, one end of the first sliding piece is formed with a first clamping plate, and the first clamping plate is fixedly sleeved on the first transmission shaft belt.

[0008] As an improved scheme of the present application, the sample adding and piercing assembly comprises a first mounting frame, a second driving motor, a second sliding piece, a piercing needle and a sample adding needle, the sample adding needle is fixedly arranged on the second sliding piece; the first mounting frame is fixedly arranged on the base, and the second driving motor is fixedly arranged on the first mounting frame; the first mounting frame is provided with a second sliding rail and a second fixing seat, a second transmission shaft belt is sleeved on the second driving motor and the second fixing seat, the second sliding piece is embedded on the second sliding rail, one side of the second sliding piece is provided with a second clamping plate, and the second clamping plate is fixedly sleeved on the second transmission shaft belt.

[0009] As an improved scheme of the present application, the plunger assembly comprises a second mounting frame, a plunger cylinder, a plunger motor, a motor lead screw and a connecting piece, the second mounting frame is fixedly arranged on one side of the first mounting frame, and the plunger cylinder and the plunger motor are fixedly arranged on the second mounting frame; one end of the plunger rod of the plunger cylinder is embedded on the connecting piece, the output shaft of the plunger motor is fixedly connected with one end of the motor lead screw, and the other end of the motor lead screw is sleeved on the connecting piece; one end of the plunger cylinder away from the connecting piece is provided with a gas hole, and the plunger cylinder is pneumatically connected with the sample adding needle through the gas hole.

[0010] As an improved scheme of the present application, at least one signal receiver and at least one illuminating lamp are respectively arranged in the signal detection plate and the light plate, and at least one first slot and at least one second slot are respectively arranged on the opposite surfaces of the signal detection plate and the light plate, and the signal receiver and the illuminating lamp are respectively arranged opposite to the first slot and the second slot.

[0011] The present application also provides a reagent card strip for the single-portion coagulation analysis device. Beneficial effects

[0012] The present application has the beneficial effects that, compared with the prior art, the single-portion coagulation analysis device provided by the present application comprises a card strip in-out assembly, an optical assembly, a plunger assembly, a sample adding and piercing assembly and a control panel, the optical assembly is movably arranged on the card strip in-out assembly, the plunger assembly and the sample adding and piercing assembly are fixedly arranged on one side of the card strip in-out assembly, and the plunger assembly is pneumatically connected with the sample adding and piercing assembly; in operation, the reagent card strip is inserted into the optical assembly, the card strip in-out assembly drives the optical assembly to the sample adding and piercing assembly, the sample adding and piercing assembly pierces and adds sample to the reagent card strip, and the optical assembly detects the coagulation of the reagent card strip; the present application can quickly detect multiple coagulation items at one time, the sample adding needle and the piercing needle pierce and add sample to multiple test ends of the reagent card strip in sequence, and then the light plate and the signal detection plate detect the test ends of the reagent card strip, and each test end is provided with an illuminating lamp and a signal receiver, so that the detection efficiency and accuracy are improved, and the whole detection process is fully automated, so that the precision and detection speed are significantly improved. BRIEF DESCRIPTION OF DRAWINGS

[0013] Fig. 1 is a perspective view of the present application;

[0014] Fig. 2 is a rear view of the present application;

[0015] Fig. 3 is a schematic view of the sample adding and piercing assembly of the present application;

[0016] Fig. 4 is a schematic view of the card strip in-out assembly of the present application;

[0017] Fig. 5 is a schematic view of the optical assembly of the present application;

[0018] Fig. 6 is a schematic view of the reagent card strip of the present application.

[0019] The main element symbols are explained as follows:

[0020] 1, card strip in-out assembly; 11, base; 12, first sliding rail; 13, first driving motor; 14, first transmission shaft belt; 15, first fixed seat;

[0021] 2, optical assembly; 21, light board; 211, first slot; 22, signal detection board; 221, second slot; 23, first sliding piece; 234, first clamping plate;

[0022] 3, sample adding and piercing assembly; 31, first mounting frame; 32, second driving motor; 33, second sliding piece; 331, second clamping plate; 34, piercing needle; 35, sample adding needle; 36, second transmission shaft; 37, second sliding rail; 38, second fixing seat;

[0023] 4, plunger assembly; 41, plunger cylinder; 411, air hole; 42, plunger motor; 43, motor screw; 44, second mounting frame; 45, connecting piece;

[0024] 5, main body; 51, sample groove; 52, TIP groove; 53, reagent groove; 54, test groove; 55, TIP head. Best mode of the present application

[0025] In order to more clearly illustrate the present application, the present application will be further described below in conjunction with the accompanying drawings.

[0026] In the following description, the example details are given in order to provide a more in-depth understanding of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, not all the embodiments. It should be understood that the described specific embodiments are only used to explain the present application, and are not used to limit the present application.

[0027] It should be understood that when the terms "comprise" and / or "include" are used in the specification, it means that the features, whole, steps, operations, elements or components exist, but do not exclude the presence or addition of one or more other features, whole, steps, operations, elements, components or combinations thereof.

[0028] Please refer to FIG. 1-6, the present application provides a single serving coagulation analysis device, including card strip access assembly 1, optical assembly 2, plunger assembly 4 and sample adding and piercing assembly 3, optical assembly 2 is movably arranged on card strip access assembly 1, plunger assembly 4 and sample adding and piercing assembly 3 are fixedly arranged on one side of card strip access assembly 1, plunger assembly 4 and sample adding and piercing assembly 3 are pneumatically connected; the reagent card strip is installed on the optical assembly 2, the position of the optical assembly 2 is controlled through the card strip access assembly 1, so that the reagent card strip moves to the position directly below the sample adding and piercing assembly 3, the piercing and sample adding operation is carried out, finally the blood sample of the reagent card strip is detected through the optical assembly 2, the detection result of the coagulation item is obtained, the operation process is fully automatic process, compared with manual operation, the detection efficiency and accuracy are significantly improved, wherein FIG. 6 is a reagent card strip product used with the device. Embodiment of the present application

[0029] The working principle of the present application is that the reagent card strip is inserted into the mounting portion of the optical assembly 2, the reagent card strip is driven by the card strip in-out assembly 1 to the lower side of the sample adding and piercing assembly 3, the piercing needle 34 of the sample adding and piercing assembly 3 pierces the test sites of the reagent card strip in turn, after piercing, the sample adding needle 35 is sleeved with a TIP head, the plunger rod of the plunger cylinder 41 is driven up and down by the plunger motor 42 of the plunger assembly 4 to generate air pressure, the blood sample is sucked by controlling the size of the air pressure, and then injected into each test site in turn, when the blood sample is discharged into the test site, the blood sample will immediately react with the reagent, the coagulation state of the blood sample in the reagent is detected by the light board 21 and the signal detection board 22 of the optical assembly 2, the light source emitted by the light board 21 transmits through the test end, the signal receiver receives the light source and converts it into an optical signal, the optical signal is transmitted to the main control board, the value of the optical signal is calculated by the main control board, the coagulation degree and coagulation time of the reagent are judged by the light intensity transmitted by the light board 21 and the change of the value of the optical signal received by the signal receiver, so as to complete the detection of the blood sample.

[0030] Please refer to FIG. 5, in the detection process, the light source emitted by the illuminating lamp in the light board 21 transmits through the test end of the reagent card strip through the first slot hole 211, reaches the signal receiver through the second slot hole 221, the signal receiver receives the optical signal and records, because the blood sample in the test end has not coagulated, it will not affect the optical signal received by the signal receiver, after the blood sample coagulates, the light transmission intensity of the blood sample will be weakened, the refractive index of the light is reduced, so that the optical signal received by the signal receiver is weakened, therefore, by judging the value of the optical signal, the coagulation time and degree of the blood sample can be calculated, finally whether the item is normal can be judged, at the same time, four coagulation items can be detected, the detection efficiency is fast, and one test end is provided with one illuminating lamp for light transmission and one signal receiver for detection, therefore, in the present application, the number of the first slot hole 211 and the second slot hole 221 is configured as 4, the detection accuracy will be more accurate; the illuminating lamp is not limited to LED lamp except for lamps.

[0031] In the present embodiment, the card strip in-out assembly 1 includes a base 11, a first sliding rail 12, a first driving motor 13, a first transmission shaft belt 14, the first driving motor 13 is arranged at one end of the base 11, one end of the first transmission shaft belt 14 is sleeved on the output shaft of the first driving motor 13, the other end of the base 11 is provided with a first fixed seat 15, the other end of the first transmission shaft belt 14 is sleeved on the first fixed seat 15; the optical assembly 2 is movably connected with the first sliding rail 12 and fixedly connected with the first transmission shaft belt 14; the plunger assembly 4 and the sample adding and piercing assembly 3 are arranged on the base 11, the transmission shaft belt is driven to rotate by the first driving motor 13, the optical assembly 2 is driven to move linearly on the first sliding rail 12.

[0032] Referring to FIG. 5, in the embodiment, the optical assembly 2 comprises a signal detection plate 22, an illumination plate 21 and a first sliding member 23, the signal detection plate 22 and the illumination plate 21 are oppositely arranged on the first sliding member 23, and the signal detection plate 22 and the illumination plate 21 are spaced apart to form a mounting portion for clamping the reagent card strip; the first sliding member 23 is embedded on the first sliding rail 12, one end of the first sliding member 23 is provided with a first clamping plate 234, the first clamping plate 234 is fixedly sleeved on the first transmission shaft belt 14, further, opposite surfaces of the signal detection plate 22 and the illumination plate 21 are respectively provided with at least one first slot hole 211 and at least one second slot hole 221, the first slot hole 211 and the second slot hole 221 are oppositely arranged, and at least one signal receiver and at least one illuminating lamp are respectively embedded in the first slot hole 211 and the second slot hole 221, in the embodiment, the number of the first slot hole 211 and the second slot hole 221 is configured as four, each test end is matched with one illuminating lamp and one signal receiver, and the detection efficiency and the detection precision of the optical assembly 2 are improved.

[0033] Referring to FIG. 3, in the embodiment, the sample adding and piercing assembly 3 comprises a first mounting frame 31, a second driving motor 32, a second sliding member 33, a piercing needle 34 and a sample adding needle 35, the sample adding needle 35 is fixedly arranged on the second sliding member 33; the first mounting frame 31 is fixedly arranged on the base 11, and the second driving motor 32 is fixedly arranged on the first mounting frame 31; the first mounting frame 31 is provided with a second sliding rail 37 and a second fixed seat 38, the second driving motor 32 and the second fixed seat 38 are sleeved with a second transmission shaft belt 36, the second sliding member 33 is embedded on the second sliding rail 37, one side of the second sliding member 33 is provided with a second clamping plate 331, and the second clamping plate 331 is fixedly sleeved on the second transmission shaft belt 36; when the reagent card strip moves below the sample adding and piercing assembly 3, first, the piercing needle 34 pierces the sealing film on the test end of the reagent card strip in sequence, then the sample adding needle 35 is clamped into the TIP head of the reagent card strip, the sample adding needle 35 extracts the blood sample into the TIP head by the suction force provided by the plunger assembly 4 and sequentially adds the blood sample into the test end to perform blood clotting detection, when the next blood sample is detected, the TIP head 55 of the last reagent card strip is thrown away, and the above piercing and sample adding operation steps are continuously repeated, and the design that the TIP head is used once can prevent the blood sample from being contaminated due to repeated use.

[0034] Please refer to Fig. 2, in the embodiment, the plunger assembly 4 comprises a plunger cylinder 41, a motor screw rod 43 and a connecting piece 45, the plunger cylinder 41 is connected with the sample adding and piercing assembly 3; one end of a plunger rod of the plunger cylinder 41 is embedded on the connecting piece 45, the motor screw rod 43 is sleeved on the connecting piece 45; the plunger cylinder 41 is pneumatically connected with the sample adding needle 35; in operation, the motor screw rod 43 rotates to drive the connecting piece 45 to move up and down linearly, so as to drive the plunger rod to move up and down linearly; the plunger electric drive motor screw rod 43 rotates, the motor screw rod 43 drives the connecting piece 45 to make the plunger rod move up and down linearly, changes the gas pressure in the plunger cylinder, the plunger cylinder 41 is provided with a gas hole 411, the gas hole 411 and the sample adding needle 35 are connected through a conduit, the gas pressure in the plunger cylinder 41 is controlled to enable the sample adding needle 35 to suck and discharge the blood sample.

[0035] Please refer to Fig. 6, the reagent card strip provided by the application comprises a main body 5, sample grooves 51, TIP grooves 52, reagent grooves 53 and test grooves 54 are sequentially arranged on the main body 5, wherein the sample grooves 51 are used for placing blood samples to be detected, the number of the reagent grooves 53 and the test grooves 54 is respectively set as 5 and 4, reagent solutions and cleaning liquids for assisting in detecting blood samples are placed in the reagent grooves 53, the test grooves 54 correspond to four coagulation detection items, namely prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB), a TIP head 55 is arranged in the TIP groove 52, the TIP head 55 is used for extracting the sample grooves 51 and the reagent grooves 53 and adding into the test grooves 54. Industrial applicability

[0036] The advantages of the application are as follows:

[0037] 1) The product detection process of the application is fully automatic, precise and rapid detection is carried out through a machine, the detection time is accurately controlled, the detection efficiency and detection precision are high, and multiple coagulation detections can be carried out at a time by using a matched reagent card strip.

[0038] The above disclosure is only several specific embodiments of the application, but the application is not limited thereto, and any changes that can be thought of by those skilled in the art shall fall within the protection scope of the application.

Claims

1. A single serving coagulation analysis device, characterized by, The application relates to a reagent card strip feeding and discharging assembly, an optical assembly, a plunger assembly and a sample adding and piercing assembly.

2. A single test coagulation analysis device according to claim 1, wherein The reagent card strip feeding and discharging assembly comprises a base, a first sliding rail, a first driving motor and a first transmission shaft belt, the first driving motor is arranged at one end of the base, one end of the first transmission shaft belt is sleeved on an output shaft of the first driving motor, the other end of the base is provided with a first fixing seat, and the other end of the first transmission shaft belt is sleeved on the first fixing seat. The optical assembly is movably connected with the first sliding rail and fixedly connected with the first transmission shaft belt; and the plunger assembly and the sample adding and piercing assembly are arranged on the base.

3. A single test coagulation analysis device according to claim 2, wherein, The optical assembly comprises a signal detection plate, an illumination plate and a first sliding piece, the signal detection plate and the illumination plate are fixedly arranged on the first sliding piece in opposition, and the signal detection plate and the illumination plate are arranged in a spaced mode to form an installation part for clamping a reagent card strip; one end of the first sliding piece is formed with a first clamping plate, and the first clamping plate is fixedly sleeved on the first transmission shaft belt.

4. A single test coagulation analysis device according to claim 2, wherein, The sample adding and piercing assembly comprises a first mounting frame, a second driving motor, a second sliding piece, a piercing needle and a sample adding needle with a hollow structure, the first mounting frame is fixedly arranged on the base, and the second driving motor is fixedly arranged on the first mounting frame; the first mounting frame is provided with a second sliding rail and a second fixing seat, a second transmission shaft belt is sleeved on an output shaft of the second driving motor and the second fixing seat, the second sliding piece is embedded on the second sliding rail, one side of the second sliding piece is provided with a second clamping plate, and the second clamping plate is fixedly sleeved on the second transmission shaft belt; and the sample adding needle is fixedly arranged on the second sliding piece.

5. A single test coagulation analysis device according to claim 4, wherein, The plunger assembly comprises a second mounting frame, a plunger cylinder, a plunger motor, a motor screw rod and a connecting piece, the second mounting frame is fixedly arranged on one side of the first mounting frame, the plunger cylinder and the plunger motor are fixedly arranged on the second mounting frame; one end of a plunger rod of the plunger cylinder is embedded on the connecting piece, an output shaft of the plunger motor is fixedly connected with one end of the motor screw rod, and the other end of the motor screw rod is sleeved on the connecting piece; one end of the plunger cylinder away from the connecting piece is provided with an air hole, and the plunger cylinder is pneumatically connected with the sample adding needle through the air hole.

6. A single test coagulation analysis device according to claim 3, wherein, The opposite faces of the signal detection plate and the light board are respectively provided with at least one first slot hole and at least one second slot hole, the first slot hole and the second slot hole are oppositely arranged, and at least one signal receiver and at least one illuminating lamp are respectively embedded in the first slot hole and the second slot hole.

7. The single test coagulation analysis device of claim 1, wherein, The optical assembly, the plunger assembly, the sample adding and piercing assembly and the control board are electrically connected.

8. A reagent card strip, characterized by, A detection device for the single-portion coagulation analysis device according to any one of claims 1-7.

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