Multi-functional pilot platform based solution preparation system, and solution preparation chromatography system thereof

Abstract

A multi-functional pilot platform-based solution preparation system and a solution preparation chromatography system thereof. The platform system comprises a first input main pipe (5) and a second input main pipe (19) respectively connected to a plurality of input pipes. An outlet end of each of the input pipes is connected to a corresponding liquid inlet port of a movable mounting module (40). The movable mounting module (40) is further provided with a plurality of liquid outlet ports. Each of the liquid outlet ports is connected to a plurality of collection pipes by means of output pipes. The first input main pipe (5) is connected to the two collection pipes respectively by means of valves. The second input main pipe (19) is connected to the plurality of collection pipes respectively by means of valves. The second input main pipe (19) is connected to the first input main pipe (5) by means of a valve. The first input module is connected to an external pump module by means of a valve. A plurality of chromatography columns is mounted on an inner housing of the movable mounting module (40). The present invention has a single pump and a dual pump which can achieve ternary liquid preparation and quaternary online dilution and liquid preparation, and achieves online liquid preparation and chromatography.

Description

Liquid preparation system and liquid preparation chromatography system based on multifunctional pilot platform Technical Field

[0001] This invention relates to downstream liquid preparation systems in the pharmaceutical field, and particularly to a liquid preparation system based on a multifunctional pilot platform and its liquid preparation chromatography system. Background Technology

[0002] Online buffer preparation systems are used to mix diluents (water for injection) and several single-component concentrated solutions (acids, bases, salts, etc.) online according to the required amounts to obtain the final buffer solution needed for production. In existing technologies, these solutions are typically prepared using a precision plunger pump and mixer, then collected and delivered from a storage tank when needed. Alternatively, the preparation system is directly connected to the chromatography column to provide the buffer solution required for chromatography. Its disadvantages are: limited functionality, inability to meet the needs of different operating conditions for buffer preparation or buffer preparation chromatography, relatively narrow application range, and increased cost due to the need for multiple systems. Summary of the Invention

[0003] To overcome the shortcomings of the prior art, this invention provides a solution preparation system and its solution preparation chromatography system based on a multifunctional pilot platform. This system can perform both solution preparation and chromatography, expanding its functionality and meeting the needs of production processes under different operating conditions.

[0004] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0005] To address the aforementioned technical problems, the first aspect of this invention discloses a liquid preparation system based on a multifunctional automatic pilot platform. This platform system includes a first input main pipeline with a first input pump and a second input main pipeline with a second input pump. The first input main pipeline connects to multiple input pipelines, with their on / off states controlled by corresponding valves. The second input main pipeline also connects to the aforementioned multiple input pipelines, with its on / off state controlled by corresponding valves. The outlet end of each input pipeline is connected to the inlet port of its corresponding movable mounting module, and the movable mounting module is also provided with multiple outlet ports. Each outlet port is connected to multiple collection pipelines via an output pipeline. The first input main pipeline is connected to two of the aforementioned collection pipelines via valves. The second input main pipeline is connected to the aforementioned multiple collection pipelines via valves. The second input main pipeline is connected to the first input main pipeline via valves. The first input module is connected to an external pump module via valves. A mixer is installed on the first input main pipeline. The connection ends of the second input main pipeline, the external pump module, and the first input main pipeline are located on one side of the mixer inlet end.

[0006] In some embodiments, there are two input pipes, and the corresponding inlet port, outlet port, and output pipe of the movable mounting module are each provided in two.

[0007] In some embodiments, the outlet end of the first input main pipe is connected to a first valve array group, which includes four valves connected end to end to form a rectangular valve array; one pair of opposite sides of the rectangular valve array is connected to the outlet end of the first input main pipe, connecting to the outlet of the pipe; the output end of the connecting pipe is connected to the multiple collection pipes through multiple intermediate pipes; the other pair of opposite sides of the rectangular valve array is connected to the inlet of two input pipes.

[0008] In some embodiments, the second input main pipe is connected to the output end of the pipe via a pipe, and a valve is installed on the pipe.

[0009] In some embodiments, the input pipe and the output pipe are connected one-to-one by pipes, and valves are installed on the pipes.

[0010] In some embodiments, two collection pipes are provided.

[0011] In some embodiments, the two output pipes are respectively connected to a second valve array group, which includes four valves connected end to end to form a rectangular valve array; one set of opposite sides of the rectangular valve array is respectively connected to the outlet end of the output pipe; the other set of opposite sides of the rectangular valve array is respectively connected to the inlet of the two collection pipes.

[0012] In some embodiments, the external pump module includes a third input main pipe, the inlet end of which is provided with a plurality of input pumps, and the third input main pipe is connected to a first input main pipe respectively.

[0013] In some embodiments, the inlet end of the third input main pipe is provided with one or two input pumps.

[0014] In some embodiments, pressure sensors and / or flow sensors are respectively provided on the first input main pipe and / or the second input main pipe and / or the external pump module.

[0015] In some embodiments, the collection pipe is respectively provided with an ultraviolet sensor and / or a first conductivity sensor and / or a pH sensor.

[0016] The first aspect of this invention discloses a liquid preparation chromatography system based on a multifunctional automatic pilot platform. This platform system includes a first input main pipeline with a first input pump and a second input main pipeline with a second input pump. The first input main pipeline connects to multiple input pipelines, and their on / off states are controlled by corresponding valves. The second input main pipeline also connects to the aforementioned multiple input pipelines, and their on / off states are controlled by corresponding valves. The outlet end of each input pipeline is connected to the inlet port of its corresponding movable mounting module. The movable mounting module also has multiple outlet ports. Each outlet port is connected to multiple collection pipelines via an output pipeline. The first input... The main pipeline is connected to the two collection pipelines mentioned above via valves; the second input main pipeline is connected to the multiple collection pipelines mentioned above via valves; the second input main pipeline is connected to the first input main pipeline via valves; the first input module is connected to the external pump module via valves; a mixer and a bubble trap are installed on the first input main pipeline; the connection ends of the second input main pipeline, the external pump module, and the first input main pipeline are located on one side of the mixer inlet end; multiple chromatography columns are placed inside the movable mounting module, and the bottom inlet and outlet of each chromatography column are connected to the input pipeline via corresponding inlet ports; the top inlet and outlet of the chromatography column are connected to the output pipeline via corresponding outlet ports.

[0017] In some embodiments, there are two input pipes, and two corresponding inlet ports, two outlet ports, and two output pipes for the movable mounting module. The chromatography column may be one or two.

[0018] In some embodiments, the outlet end of the first input main pipe is connected to a first valve array group, which includes four valves connected end to end to form a rectangular valve array; one pair of opposite sides of the rectangular valve array is connected to the outlet end of the first input main pipe, connecting to the outlet of the pipe; the output end of the connecting pipe is connected to the multiple collection pipes through multiple intermediate pipes; the other pair of opposite sides of the rectangular valve array is connected to the inlet of two input pipes.

[0019] In some embodiments, the second input main pipe is connected to the output end of the pipe via a pipe, and a valve is installed on the pipe.

[0020] In some embodiments, the input pipe and the output pipe are connected one-to-one by pipes, and valves are installed on the pipes.

[0021] In some embodiments, two collection pipes are provided.

[0022] In some embodiments, the two output pipes are respectively connected to a second valve array group, which includes four valves connected end to end to form a rectangular valve array; one set of opposite sides of the rectangular valve array is respectively connected to the outlet end of the output pipe; the other set of opposite sides of the rectangular valve array is respectively connected to the inlet of the two collection pipes.

[0023] In some embodiments, the external pump module includes a third input main pipe, the inlet end of which is provided with a plurality of input pumps, and the third input main pipe is connected to a first input main pipe respectively.

[0024] In some embodiments, the inlet end of the third input main pipe is provided with one or two input pumps.

[0025] In some embodiments, pressure sensors and / or flow sensors are respectively provided on the first input main pipe and / or the second input main pipe and / or the external pump module.

[0026] In some embodiments, the collection pipe is respectively provided with an ultraviolet sensor and / or a first conductivity sensor and / or a pH sensor.

[0027] The beneficial effects of this invention are:

[0028] This invention adds an external pump module to a multifunctional automatic pilot platform, enabling liquid preparation and expanding its application range. Simultaneously, single and dual pumps can be used to achieve ternary and quaternary online dilution and preparation.

[0029] This invention adds an external pump module and a chromatography column to the multifunctional automatic pilot platform, realizing online solution preparation chromatography. Attached Figure Description

[0030] Figure 1 is a schematic diagram of the liquid preparation system of the present invention.

[0031] Figure 2 is a schematic diagram of the solution chromatography structure of the present invention. Detailed Implementation

[0032] The invention will now be further described with reference to the accompanying drawings.

[0033] The technical content of the present invention is illustrated below through specific embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments. Those skilled in the art can make various modifications and changes without departing from the spirit of the present invention.

[0034] Before detailing the specific embodiments of this disclosure, some terms used in this disclosure will be explained first.

[0035] Unless otherwise defined below, all technical and scientific terms used herein are intended to have the same meaning as commonly understood by one of ordinary skill in the art. References to technical terms herein refer to techniques commonly understood in the art, including variations or equivalent substitutions of techniques that are obvious to one of ordinary skill in the art. While it is believed that the following terms will be well understood by one of ordinary skill in the art, the following definitions are set forth to better explain the invention. When trade names appear herein, they are intended to refer to the corresponding goods or services. All patents, published patent applications, and publications cited herein are incorporated herein by reference.

[0036] Unless otherwise stated in the text, multiple references such as "a kind of" or "the" include plural references. The expressions "a kind of or more kinds of" or "at least one kind of" can mean 1, 2, 3, 4, 5, 6, 7, 8, 9 kinds of or more kinds of.

[0037] The terms “connection,” “link,” “coupled,” or “coupled” used in this article are not limited to direct connections; they also include indirect connections.

[0038] As used in this article, “sample” refers to biomolecules, including proteins, nucleic acids, lipids, carbohydrates, small nucleotides, amino acids and their derivatives.

[0039] As used herein, "online monitoring" or "real-time monitoring" refers to the real-time detection of certain parameters or properties of the buffer solution, reaction fluid, or fluid exiting the flow reactor during the use of the chromatography system, such as pH, pressure, flow rate, and conductivity. Unlike offline detection or analysis, online or real-time monitoring provides immediate feedback on the detection results.

[0040] The storage tanks A2, A3, A4, A5, P1, P1-W, P2, and P2-W mentioned in this article refer to tanks used for storing different solutions, not necessarily tanks with specific limitations. Any container that can perform the storage function is acceptable.

[0041] The positional terms "up," "down," "left," "right," "front," and "back" used in this article are determined based on the layout direction of the accompanying drawings in the specification. They are only used to indicate relative positional relationships. When the absolute position of the object being described changes, the relative positional relationship may also change accordingly.

[0042] This patent is applicable to laboratory and pilot-scale applications, with a maximum flow rate of 1000 ml / min for a single pump.

[0043] Referring to Figure 1, the liquid preparation system based on the multi-functional automatic pilot platform includes a first input main pipe 5. The input end of the first input main pipe 5 is connected to the A2 storage tank via a first valve 1 and to the A1 storage tank via a second valve 12. From left to right, the first input main pipe 5 is equipped with a first input pump 2, a first pressure sensor 3, a first flow sensor 4, a third valve 6, a mixer 7, and an air trap 8.

[0044] The second input main pipe 19 connects to the A3 storage tank via the fourth valve 15, the A4 storage tank via the fifth valve 14, and the A5 storage tank via the sixth valve. From left to right, the second input main pipe 19 is equipped with a second input pump 16, a second pressure sensor 17, and a second flow sensor 18. The second input main pipe 19 connects to the first input main pipe 5 via the seventh valve 20, with the connection point located between the third valve 6 and the mixer 7. The A3 storage tank is connected to the inlet of the first input main pipe 5 via the thirty-seventh valve 13.

[0045] The external pump module includes a third input main pipe 30. The input end of the third input main pipe 30 is connected to the A6 storage tank via the eighth valve 25 and to the A7 storage tank via the ninth valve 26. From left to right, the third input main pipe 30 is equipped with a third input pump 27, a third pressure sensor 28, and a third flow sensor 29. The third input main pipe 30 is connected to the first input main pipe 5 via the tenth valve 22, with the connection point located between the third valve 6 and the mixer 7.

[0046] The output end of the first input main pipe 5 is connected to the first valve array group 32. The first valve array group 32 includes four valves connected end to end, forming a rectangular valve array, including the eleventh valve 33, the twelfth valve 34, the thirteenth valve 35, and the fourteenth valve 36. The output end of the first input main pipe 5 is connected between the eleventh valve 33 and the fourteenth valve 36; the inlet end of the first connecting pipe 78 is connected between the twelfth valve 34 and the thirteenth valve 35. The outlet end of the first connecting pipe 78 is connected to the inlet end of the first intermediate pipe connection 66 and the second intermediate pipe 67 through the fifteenth valve 65 and the sixteenth valve 64, respectively. The outlet ends of the first intermediate pipe connection 66 and the second intermediate pipe 67 are connected to the outlet ends of the first collecting pipe 53 and the second collecting pipe 54, respectively, through the nineteenth valve 60 and the twentieth valve 62, respectively. The second input main pipe 19 is connected to the outlet end of the first connecting pipe 78 through the second connecting pipe 23. The two ends of the second connecting pipe 23 are respectively provided with the seventeenth valve 21 and the eighteenth valve 31. The eleventh valve 33 and the twelfth valve 34 are connected to the inlet end of the first input pipe 38. The outlet end of the first input pipe 38 is connected to the first liquid inlet port 39 of the movable mounting module 40. The first input pipe 38 is equipped with the twenty-first valve 37. The thirteenth valve 35 and the fourteenth valve 36 are connected to the inlet end of the second input pipe 42. The outlet end of the second input pipe 42 is connected to the second liquid inlet port 41 of the movable mounting module 40. The second input pipe 42 is equipped with the twenty-second valve 79. The first liquid outlet port 50 of the movable mounting module 40 is connected to the inlet end of the first output pipe 75. The second liquid outlet port 44 of the movable mounting module 40 is connected to the second output pipe 43. The first output pipe 75 is equipped with the twenty-third valve 51 and the twenty-fourth valve 52. The second output pipe 43 is equipped with the twenty-fifth valve 80 and the twenty-sixth valve 49. The first input pipe 38 and the first output pipe 75 are connected by a third connecting pipe 45. One end of the third connecting pipe 45 is located between the twenty-first valve 37 and the first valve array 32, and the other end is located between the twenty-third valve 51 and the twenty-fourth valve 52. A twenty-seventh valve 46 is installed on the third connecting pipe 45. The second input pipe 42 and the second output pipe 43 are connected by a fourth connecting pipe 47. One end of the fourth connecting pipe 47 is located between the twenty-second valve 79 and the first valve array 32, and the other end is located between the twenty-fifth valve 80 and the twenty-sixth valve 49. A twenty-eighth valve 48 is installed on the fourth connecting pipe 47. The first output pipe 75 and the second output pipe 43 are respectively connected to the second valve array group 70. The second valve array group 70 includes four valves connected end to end to form a rectangular valve array, including the twenty-ninth valve 71, the thirtieth valve 72, the thirty-first valve 73, and the thirty-second valve 74.The outlet of the second output pipe 43 is connected between valve 71 (29th) and valve 74 (32nd). The outlet of the first output pipe 75 is connected between valve 72 (30th) and valve 73 (31st). The inlet of the first collection pipe 53 is connected between valve 71 (29th) and valve 72 (30th). The inlet of the second collection pipe 54 is connected between valve 73 (31st) and valve 74 (32nd). A first ultraviolet sensor 55, a first conductivity sensor 56, and a first pH sensor 57 are installed on the first collection pipe 53. The outlet of the first collection pipe 53 is connected to storage tanks P1 and P1-W via valves 58 (33rd) and 59 (34th). A second conductivity sensor 68 and a second pH sensor 69 are installed on the second collection pipe 54. The outlet of the second collection pipe 54 is connected to storage tanks P2 and P2-W via valves 61 (35th) and 63 (36th).

[0047] Referring to Figure 2, the liquid preparation chromatography system based on the multifunctional automatic pilot platform includes a first input main pipeline 5. The input end of the first input main pipeline 5 is connected to the A2 storage tank via a first valve 1 and to the A1 storage tank via a second valve 12. From left to right, the first input main pipeline 5 is equipped with a first input pump 2, a first pressure sensor 3, a first flow sensor 4, a third valve 6, a mixer 7, and an air trap 8.

[0048] The second input main pipe 19 connects to the A3 storage tank via the fourth valve 15, the A4 storage tank via the fifth valve 14, and the A5 storage tank via the sixth valve. From left to right, the second input main pipe 19 is equipped with a second input pump 16, a second pressure sensor 17, and a second flow sensor 18. The second input main pipe 19 connects to the first input main pipe 5 via the seventh valve 20, with the connection point located between the third valve 6 and the mixer 7. The A3 storage tank is connected to the inlet of the first input main pipe 5 via the thirty-seventh valve 13.

[0049] The external pump module includes a third input main pipe 30. The input end of the third input main pipe 30 is connected to the A6 storage tank via the eighth valve 25 and to the A7 storage tank via the ninth valve 26. From left to right, the third input main pipe 30 is equipped with a third input pump 27, a third pressure sensor 28, and a third flow sensor 29. The third input main pipe 30 is connected to the first input main pipe 5 via the tenth valve 22, with the connection point located between the third valve 6 and the mixer 7.

[0050] The output end of the first input main pipe 5 is connected to the first valve array group 32. The first valve array group 32 includes four valves connected end to end, forming a rectangular valve array, including the eleventh valve 33, the twelfth valve 34, the thirteenth valve 35, and the fourteenth valve 36. The output end of the first input main pipe 5 is connected between the eleventh valve 33 and the fourteenth valve 36; the inlet end of the first connecting pipe 78 is connected between the twelfth valve 34 and the thirteenth valve 35. The outlet end of the first connecting pipe 78 is connected to the inlet end of the first intermediate pipe connection 66 and the second intermediate pipe 67 through the fifteenth valve 65 and the sixteenth valve 64, respectively. The outlet ends of the first intermediate pipe connection 66 and the second intermediate pipe 67 are connected to the outlet ends of the first collecting pipe 53 and the second collecting pipe 54, respectively, through the nineteenth valve 60 and the twentieth valve 62, respectively. The second input main pipe 19 is connected to the outlet end of the first connecting pipe 78 through the second connecting pipe 23. The two ends of the second connecting pipe 23 are respectively provided with the seventeenth valve 21 and the eighteenth valve 31. The eleventh valve 33 and the twelfth valve 34 are connected to the inlet end of the first input pipe 38. The outlet end of the first input pipe 38 is connected to the first inlet port 39 of the movable mounting module 40. A twenty-first valve 37 is installed on the first input pipe 38. The thirteenth valve 35 and the fourteenth valve 36 are connected to the inlet end of the second input pipe 42. The outlet end of the second input pipe 42 is connected to the second inlet port 41 of the movable mounting module 40. A twenty-second valve 79 is installed on the second input pipe 42. The first inlet port 39 is connected to the bottom inlet and outlet of the first chromatography column 76, and the second inlet port 41 is connected to the bottom inlet and outlet of the second chromatography column 77. The top inlet and outlet of the first chromatography column 76 are connected to the first outlet port 50 of the movable mounting module 40. The top inlet and outlet of the second chromatography column 77 are connected to the second outlet port 44 of the movable mounting module 40. The first outlet port 50 of the movable mounting module 40 is connected to the inlet end of the first output pipe 75, and the second outlet port 44 of the movable mounting module 40 is connected to the second output pipe 43. The first output pipe 75 is equipped with a twenty-third valve 51 and a twenty-fourth valve 52. The second output pipe 43 is equipped with a twenty-fifth valve 80 and a twenty-sixth valve 49. The first input pipe 38 and the first output pipe 75 are connected by a third connecting pipe 45. One end of the third connecting pipe 45 is located between the twenty-first valve 37 and the first valve array 32, and the other end is located between the twenty-third valve 51 and the twenty-fourth valve 52. A twenty-seventh valve 46 is installed on the third connecting pipe 45. The second input pipe 42 and the second output pipe 43 are connected by a fourth connecting pipe 47. One end of the fourth connecting pipe 47 is located between the twenty-second valve 79 and the first valve array 32, and the other end is located between the twenty-fifth valve 80 and the twenty-sixth valve 49. A twenty-eighth valve 48 is installed on the fourth connecting pipe 47.The first output pipe 75 and the second output pipe 43 are respectively connected to the second valve array group 70. The second valve array group 70 includes four valves connected end to end, forming a rectangular valve array, including the twenty-ninth valve 71, the thirtieth valve 72, the thirty-first valve 73, and the thirty-second valve 74. The outlet of the second output pipe 43 is connected between the twenty-ninth valve 71 and the thirty-second valve 74, the outlet of the first output pipe 75 is connected between the thirtieth valve 72 and the thirty-first valve 73, the inlet of the first collection pipe 53 is connected between the twenty-ninth valve 71 and the thirtieth valve 72, and the inlet of the second collection pipe 54 is connected between the thirty-first valve 73 and the thirty-second valve 74. The first collection pipe 53 is respectively equipped with a first ultraviolet sensor 55, a first conductivity sensor 56, and a first pH sensor 57. The outlet of the first collection pipe 53 is connected to the P1 storage tank and the P1-W storage tank through the thirty-third valve 58 and the thirty-fourth valve 59, respectively. The second collection pipe 54 is equipped with a second conductivity sensor 68 and a second pH sensor 69. The outlet end of the second collection pipe 54 is connected to the P2 storage tank and the P2-W storage tank through the thirty-fifth valve 61 and the thirty-sixth valve 63.

Claims

1. A solution preparation system based on a multifunctional pilot platform, characterized in that, The pilot platform includes a first input main pipe with a first input pump and a second input main pipe with a second input pump. The first input main pipe connects to multiple input pipes, and their on / off states are controlled by corresponding valves. The second input main pipe also connects to the aforementioned multiple input pipes, and their on / off states are controlled by corresponding valves. The outlet end of each input pipe is connected to the inlet port of its corresponding movable mounting module, and the movable mounting module is also provided with multiple outlet ports. Each outlet port is connected to multiple collection pipes via an output pipe. The first input main pipe is connected to two of the aforementioned collection pipes via valves. The second input main pipe is connected to the aforementioned multiple collection pipes via valves. The second input main pipe is connected to the first input main pipe via a valve. The first input main pipe is connected to an external pump module via a valve. A mixer is installed on the first input main pipe. The connection ends of the second input main pipe, the external pump module, and the first input main pipe are located on one side of the mixer inlet end.

2. The solution preparation system based on a multifunctional pilot platform according to claim 1, characterized in that, The aforementioned input pipeline is provided in two parts, and the corresponding movable installation module has two inlet ports, two outlet ports, and two output pipelines.

3. The solution preparation system based on a multifunctional pilot platform according to claim 2, characterized in that, The outlet end of the first input main pipe is connected to the first valve array group, which includes four valves connected end to end to form a rectangular valve array. One pair of opposite sides of the rectangular valve array is connected to the outlet end of the first input main pipe, which is the outlet of the connecting pipe. The output end of the connecting pipe is connected to the multiple collection pipes through multiple intermediate pipes. The other pair of opposite sides of the rectangular valve array is connected to the inlet of two input pipes.

4. The solution preparation system based on a multifunctional pilot platform according to claim 3, characterized in that, The second input main pipeline is connected to the output end of the pipeline, and a valve is installed on the pipeline.

5. The solution preparation system based on a multifunctional pilot platform according to claim 3, characterized in that, The input and output pipes are connected one-to-one by pipes, and valves are installed on the pipes.

6. The solution preparation system based on a multifunctional pilot platform according to claim 3, characterized in that, There are two collection pipes.

7. The solution preparation system based on a multifunctional pilot platform according to claim 3, characterized in that, The two output pipes are respectively connected to the second valve array group, which includes four valves connected end to end to form a rectangular valve array; one pair of opposite sides of the rectangular valve array is respectively connected to the outlet end of the output pipe; the other pair of opposite sides of the rectangular valve array is respectively connected to the inlet of the two collection pipes.

8. The solution preparation system based on a multifunctional pilot platform according to claim 3, characterized in that, The external pump module includes a third input main pipe, and multiple input pumps are installed at the inlet end of the third input main pipe. The third input main pipe is connected to the first input main pipe.

9. The solution preparation system based on a multifunctional pilot platform according to claim 8, characterized in that, The inlet end of the third input main pipeline is equipped with one or two input pumps.

10. A liquid preparation chromatography system based on a multifunctional pilot platform, characterized in that, The pilot platform includes a first input main pipe with a first input pump and a second input main pipe with a second input pump. The first input main pipe connects to multiple input pipes, and their on / off states are controlled by corresponding valves. The second input main pipe also connects to the aforementioned multiple input pipes, and their on / off states are controlled by corresponding valves. The outlet end of each input pipe is connected to the inlet port of its corresponding movable mounting module, and the movable mounting module is also provided with multiple outlet ports. Each outlet port is connected to multiple collection pipes via an output pipe. The first input main pipe is connected to two of the aforementioned collection pipes via valves. The second input main pipe is connected to the aforementioned multiple collection pipes via valves. The second input main pipe is connected to the first input main pipe via valves. The first input main pipe is connected to an external pump module via valves. A mixer and a bubble trap are provided on the first input main pipe. The connection ends of the second input main pipe, the external pump module, and the first input main pipe are located on one side of the mixer inlet end. Multiple chromatography columns are placed inside the movable mounting module. The bottom inlet and outlet of each chromatography column are connected to the input pipe via corresponding inlet ports. The top inlet and outlet of the chromatography column are connected to the output pipe via corresponding outlet ports.

11. The liquid preparation chromatography system based on a multifunctional pilot platform according to claim 10, characterized in that, The input pipeline is provided in two places, and the corresponding inlet port, outlet port and output pipeline of the movable installation module are provided in two places respectively. The chromatography column can be one or two.

12. The liquid preparation chromatography system based on a multifunctional pilot platform according to claim 11, characterized in that, The outlet end of the first input main pipe is connected to the first valve array group, which includes four valves connected end to end to form a rectangular valve array. One pair of opposite sides of the rectangular valve array is connected to the outlet end of the first input main pipe, which is the outlet of the connecting pipe. The output end of the connecting pipe is connected to the multiple collection pipes through multiple intermediate pipes. The other pair of opposite sides of the rectangular valve array is connected to the inlet of two input pipes.

13. The liquid preparation chromatography system based on a multifunctional pilot platform according to claim 11, characterized in that, The second input main pipeline is connected to the output end of the pipeline, and a valve is installed on the pipeline.

14. The liquid preparation chromatography system based on a multifunctional pilot platform according to claim 11, characterized in that, The input and output pipes are connected one-to-one by pipes, and valves are installed on the pipes.

15. The liquid preparation chromatography system based on a multifunctional pilot platform according to claim 11, characterized in that, There are two collection pipes.

16. The liquid preparation chromatography system based on a multifunctional pilot platform according to claim 11, characterized in that, The two output pipes are respectively connected to the second valve array group, which includes four valves connected end to end to form a rectangular valve array; one pair of opposite sides of the rectangular valve array is respectively connected to the outlet end of the output pipe; the other pair of opposite sides of the rectangular valve array is respectively connected to the inlet of the two collection pipes.

17. The liquid preparation chromatography system based on a multifunctional pilot platform according to claim 11, characterized in that, The external pump module includes a third input main pipe, and multiple input pumps are installed at the inlet end of the third input main pipe. The third input main pipe is connected to the first input main pipe.

18. The liquid preparation chromatography system based on a multifunctional pilot platform according to claim 17, characterized in that, The inlet end of the third input main pipeline is equipped with one or two input pumps.

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