Allergen-reducing agent, method for producing allergen-reduced fiber, and allergen-reducing method

Abstract

The present invention provides an allergen-reducing agent exhibiting an excellent allergen-reducing effect. The allergen-reducing agent according to the present invention is characterized by containing at least one niobium compound among niobium oxide and niobium hydroxide, and therefore exhibits an excellent allergen-reducing effect due to the action of at least one niobium compound among niobium oxide and niobium hydroxide, and is particularly excellent in the water resistance of the allergen-reducing effect. Furthermore, the allergen-reducing agent according to the present invention exhibits an excellent allergen-reducing effect without requiring light irradiation, and exhibits an excellent allergen-reducing effect even in the dark.

Description

Allergen reducing agent, method for producing allergen-reducing fiber, and method for reducing allergens

[0001] The present invention relates to an allergen reducing agent, a method for producing allergen-reducing fibers, and a method for reducing allergens.

[0002] In recent years, many allergic diseases such as atopic dermatitis, bronchial asthma, and allergic rhinitis have become a problem. The main cause of these allergic diseases is the increase in allergens in living spaces, such as dust mites that inhabit homes, particularly house dust mites (Der1, Der2), which are abundant in indoor dust, and cedar pollen allergens (Cry j1, Cry j2), which are mainly suspended in the air in large quantities during the spring.

[0003] The allergens from house dust mites are not the mites themselves, but rather their carcasses and feces. Therefore, eliminating house dust mites does not provide a fundamental solution to allergic diseases.

[0004] Furthermore, Cry j1 and Cry j2, which are cedar pollen allergens, are glycoproteins with molecular weights of approximately 40 kDa and approximately 37 kDa, respectively, and have complex three-dimensional structures folded in a spiral or sheet-like manner. When these cedar pollen allergens adhere to the nasal mucosa, they are recognized as foreign substances outside the body and trigger an inflammatory response.

[0005] Therefore, there is a need for technologies that can remove allergens from living spaces or inactivate them by denaturing them.

[0006] Patent Document 1 discloses an interior decorative sheet having anti-allergen properties, wherein the interior decorative sheet comprises at least a base sheet with a pattern layer and a surface protective layer made of a curable resin, and the surface protective layer is blended with an anionic phenolic material having anti-allergen properties and a zinc-based material having anti-allergen properties.

[0007] Japanese Patent Publication No. 2014-69320

[0008] However, the allergen treatment ability (allergen reduction effect) of the anionic phenolic material and the zinc-based material having allergen resistance used in the interior decorative sheet having allergen resistance disclosed in Patent Document 1 is insufficient, and an allergen reducing agent having an excellent allergen reduction effect is desired.

[0009] The present invention provides an allergen reducing agent having an excellent allergen reduction effect, a method for producing an allergen reducing fiber having an excellent allergen reduction effect, and an allergen reduction method.

[0010] The allergen reducing agent of the present invention is characterized by containing at least one niobium compound of niobium oxide and niobium hydroxide.

[0011] The allergen reducing fiber of the present invention is characterized by including a fiber and at least one niobium compound of niobium oxide and niobium hydroxide present on the surface of the fiber.

[0012] The allergen reducing fabric of the present invention is characterized by including the above allergen reducing fiber.

[0013] The allergen reduction method of the present invention is characterized by reducing an allergen by bringing at least one niobium compound of niobium oxide and niobium hydroxide into contact with the allergen.

[0014] The allergen reducing agent of the present invention exhibits an excellent allergen reduction effect by the action of at least one niobium compound of niobium oxide and niobium hydroxide, and particularly has excellent water resistance of the allergen reduction effect.

[0015] In addition, the allergen reducing agent of the present invention exhibits an excellent allergen reduction effect without requiring light irradiation, and also exhibits an excellent allergen reduction effect in a dark place.

[0016] It is a graph showing the results of fluorescent X-ray measurement of the allergen reducing fabric obtained in Example 15. It is a graph showing the results of fluorescent X-ray measurement of the blank allergen reducing fabric.

[0017] In the numerical ranges described step by step in this specification, the upper limit value or the lower limit value of the numerical range at a certain step can be arbitrarily combined with the upper limit value or the lower limit value of the numerical range at other steps. In the numerical ranges described in this specification, the upper limit value or the lower limit value of the numerical range may be replaced with the value shown in the examples or the value that can be uniquely derived from the examples. In this specification, the numerical values connected by "~" mean a numerical range including the numerical values before and after "~" as the lower limit value and the upper limit value.

[0018] (Niobium compound) The allergen reducing agent of the present invention contains at least one niobium compound selected from niobium oxide and niobium hydroxide [Nb(OH)5] as an active ingredient. The niobium compound may be used alone or in combination of two or more.

[0019] The content of the niobium compound in the allergen reducing agent is preferably 50% by mass or more, more preferably 60% by mass or more, further preferably 70% by mass or more, still further preferably 80% by mass or more, yet further preferably 90% by mass or more, more preferably 95% by mass or more, still more preferably 99% by mass or more, and most preferably 100% by mass.

[0020] The content of niobium oxide in the niobium compound is preferably 50% by mass or more, more preferably 60% by mass or more, further preferably 70% by mass or more, still further preferably 80% by mass or more, yet further preferably 90% by mass or more, more preferably 95% by mass or more, still more preferably 99% by mass or more, and most preferably 100% by mass.

[0021] The content of niobium hydroxide in the niobium compound is preferably 50% by mass or more, more preferably 60% by mass or more, further preferably 70% by mass or more, still further preferably 80% by mass or more, yet further preferably 90% by mass or more, more preferably 95% by mass or more, still more preferably 99% by mass or more, and most preferably 100% by mass.

[0022] As the niobium oxide, any of niobium monoxide (NbO), niobium dioxide (NbO2), and niobium pentoxide (Nb2O5) may be used, but niobium pentoxide (Nb2O5) is preferred because it exhibits an excellent allergen reducing effect.

[0023] Niobium oxide generates niobium hydroxide when exposed to moisture supplied from an external source or moisture present in the atmosphere. The hydroxyl groups (-OH) bonded to the niobium atoms in this niobium hydroxide interact with allergens, thereby producing an allergen-reducing effect.

[0024] Niobium hydroxide exerts its allergen-reducing effect because the hydroxyl groups (-OH) bonded to the niobium atoms in its molecule interact with allergens.

[0025] Here, in niobium oxide, some of the niobium oxide reacts with moisture on its solid surface to form a layer of niobium hydroxide. However, since the amount of niobium hydroxide layer is extremely small compared to the amount of niobium oxide, it is treated as "niobium oxide" in this invention.

[0026] It is presumed that niobium hydroxide, including niobium hydroxide formed on the surface of niobium oxide, forms a cross-linked structure through dehydration condensation between hydroxyl groups, and niobium compounds have excellent water resistance. Therefore, allergen-reducing products treated with the allergen-reducing agent described later have excellent water resistance and can maintain their excellent allergen-reducing effect even after water treatment such as washing (water resistance of allergen-reducing effect).

[0027] Niobium oxide is preferably niobium oxide with niobium hydroxide formed on its surface, more preferably niobium oxide with niobium hydroxide formed entirely on its surface, more preferably niobium oxide with niobium hydroxide formed only on its surface, and most preferably niobium oxide with niobium hydroxide formed entirely only on its surface. In niobium oxide with niobium hydroxide formed on its surface, a water-resistant layer is formed by niobium hydroxide on its surface, while niobium oxide exists inside the niobium hydroxide. Even if the layer of niobium hydroxide formed on the surface decreases or disappears over time due to use, new niobium hydroxide is formed from the inner niobium oxide, forming a layer of niobium hydroxide that exhibits an excellent allergen-reducing effect, and the allergen-reducing agent can maintain a stable and excellent allergen-reducing effect over a long period of time.

[0028] Niobium compounds are preferably in particulate form. When niobium compounds are in particulate form, their surface area can be increased, improving the interaction between the niobium compounds and allergens and resulting in an excellent allergen reduction effect.

[0029] When the niobium compound is in particulate form, the volume-based D50 particle size of the niobium compound is preferably 0.001 μm or larger, more preferably 0.005 μm or larger, more preferably 0.010 μm or larger, more preferably 0.012 μm or larger, more preferably 0.015 μm or larger, more preferably 0.025 μm or larger, more preferably 0.035 μm or larger, more preferably 0.045 μm or larger, more preferably 0.055 μm or larger, more preferably 0.060 μm or larger, and more preferably 0.065 μm or larger. The volume-based D50 particle diameter of the niobium compound is more preferably 150 μm or less, more preferably 100 μm or less, more preferably 80 μm or less, more preferably 60 μm or less, more preferably 40 μm or less, more preferably 20 μm or less, more preferably 15 μm or less, more preferably 5 μm or less, more preferably 3 μm or less, more preferably 1 μm or less, more preferably 0.5 μm or less, more preferably 0.3 μm or less, and more preferably 0.2 μm or less. The volume-based D50 particle diameter of the niobium compound is more preferably 0.001 to 150 μm, more preferably 0.001 to 100 μm, more preferably 0.001 to 40 μm, and more preferably 0.001 to 5 μm. By setting the volume-based D50 particle diameter of the niobium compound within the above range, the amount of hydroxyl groups present on the surface of the particulate niobium compound can be more appropriately adjusted, resulting in an even better allergen reduction effect. Furthermore, by setting the upper limit of the volume-based D50 particle size for niobium compounds within the above range, it becomes easier to improve the dispersion stability when niobium compounds are mixed in a solvent.

[0030] When the niobium compound is in particulate form, the volume-based D90 particle size of the niobium compound is preferably 0.001 μm or larger, more preferably 0.010 μm or larger, more preferably 0.015 μm or larger, more preferably 0.020 μm or larger, more preferably 0.025 μm or larger, more preferably 0.030 μm or larger, more preferably 0.050 μm or larger, more preferably 0.07 μm or larger, more preferably 0.10 μm or larger, and more preferably 0.12 μm or larger. The volume-based D90 particle size of the niobium compound is preferably 150 μm or smaller, more preferably 130 μm or smaller, more preferably 110 μm or smaller, more preferably 90 μm or smaller, more preferably 70 μm or smaller, more preferably 50 μm or smaller, more preferably 30 μm or smaller, more preferably 10 μm or smaller, more preferably 5 μm or smaller, more preferably 1 μm or smaller, and more preferably 0.5 μm or smaller. The volume-based D90 particle size of the niobium compound is preferably 0.001 to 150 μm, more preferably 0.001 to 110 μm, more preferably 0.001 to 70 μm, and more preferably 0.001 to 50 μm. By setting the volume-based D90 particle size of the niobium compound within the above range, the inclusion of coarser particles compared to the average size of niobium compound particles is reduced, the amount of hydroxyl groups present on the surface of the particulate niobium compound can be more appropriately adjusted, and an even better allergen reduction effect can be achieved. Furthermore, by setting the upper limit of the volume-based D90 particle size of the niobium compound to the above value, the dispersion stability when the niobium compound is mixed in a solvent can be easily improved.

[0031] In addition, the volume-based D50 particle diameter and D90 particle diameter for niobium compounds refer to the particle diameters at which the cumulative frequency (cumulative from the smallest particle size) in the volume-based particle size distribution measured by laser diffraction and scattering methods reaches 50% and 90%, respectively (50% cumulative particle diameter and 90% cumulative particle diameter). In laser diffraction and scattering measurements, the refractive index of the laser diffraction and scattering particle size distribution analyzer is set to the refractive index corresponding to the niobium compound being measured (2.3 if the niobium compound is niobium pentoxide).

[0032] When the niobium compound is a fine particle, the particle size of the niobium compound may be measured as the particle size based on the scattered light intensity by the dynamic light scattering method. The D50 particle size based on the scattered light intensity of the niobium compound is preferably 0.0005 μm or more, more preferably 0.001 μm or more, more preferably 0.005 μm or more, more preferably 0.01 μm or more, more preferably 0.03 μm or more, more preferably 0.05 μm or more, and more preferably 0.07 μm or more. The D50 particle size based on the scattered light intensity of the niobium compound is preferably 10 μm or less, more preferably 5 μm or less, more preferably 1 μm or less, more preferably 0.5 μm or less, and more preferably 0.3 μm or less. The D50 particle size based on the scattered light intensity of the niobium compound is preferably 0.0005 to 10 μm, more preferably 0.001 to 5 μm, and more preferably 0.001 to 1 μm. By setting the D50 particle size based on scattered light intensity for niobium compounds within the above range, the amount of hydroxyl groups present on the surface of particulate niobium compounds can be more appropriately adjusted, resulting in an even better allergen reduction effect. Furthermore, by setting the upper limit of the D50 particle size based on scattered light intensity for niobium compounds to the above value, the dispersion stability when niobium compounds are mixed in a solvent can be more easily improved.

[0033] When the niobium compound is a fine particle, the D90 particle diameter based on scattered light intensity for the niobium compound is preferably 0.001 μm or more, more preferably 0.005 μm or more, more preferably 0.01 μm or more, more preferably 0.05 μm or more, more preferably 0.08 μm or more, more preferably 0.11 μm or more, and more preferably 0.14 μm or more. The D90 particle diameter based on scattered light intensity for the niobium compound is preferably 20 μm or less, more preferably 10 μm or less, more preferably 5 μm or less, more preferably 1 μm or less, and more preferably 0.7 μm or less. The D90 particle diameter based on scattered light intensity for the niobium compound is preferably 0.001 to 20 μm, more preferably 0.005 to 10 μm, more preferably 0.01 to 5 μm, and more preferably 0.01 to 1 μm. By setting the D90 particle size based on scattered light intensity for niobium compounds within the above range, the inclusion of coarser particles compared to the average size of niobium compound particles is reduced, allowing for a more appropriate adjustment of the amount of hydroxyl groups present on the surface of particulate niobium compounds, thereby achieving an even better allergen reduction effect. Furthermore, by setting the upper limit of the D90 particle size based on scattered light intensity for niobium compounds to the above value, the dispersion stability when niobium compounds are mixed in a solvent becomes easier to improve.

[0034] Furthermore, the D50 and D90 particle diameters based on scattered light intensity for niobium compounds refer to the particle diameters at which the cumulative frequency in the particle size distribution based on scattered light intensity by dynamic light scattering methods reaches 50% and 90%, respectively. Measurement by dynamic light scattering can be performed using a light scattering measuring device (for example, the "ZETASIZER NANO-S" manufactured by Malvern). The light scattering measuring device is prepared by adjusting the aqueous dispersion so that the concentration of the niobium compound is 0.1% by mass, and the refractive index is set to the refractive index corresponding to the niobium compound being measured (2.3 if the niobium compound is niobium pentoxide). In addition, the D50 and D90 particle diameters based on scattered light intensity can be converted to volume-based D50 and D90 particle diameters by assuming that the particles are perfectly spherical.

[0035] (Acidic compound) It is preferable that the allergen reducing agent contains an acidic compound. When the allergen reducing agent contains an acidic compound, the dehydration condensation between the hydroxyl groups of the niobium compound is promoted, facilitating the formation of a cross-linked structure and improving the water resistance of the allergen reducing effect of the allergen reducing agent.

[0036] Further, when the allergen reducing agent contains an acidic compound, when the allergen reducing agent is dispersed in a solvent (preferably water) to form an allergen reducing solution, the dispersion stability of the niobium compound in the solvent is improved. The allergen reducing agent can be more uniformly adhered to the surface of the substrate, and a more excellent allergen reducing effect can be imparted to the substrate.

[0037] The acidic compound has an acidic functional group or its salt in the molecule. The acidic functional group refers to a functional group that can release hydrogen ions (protons) in an aqueous solution. The acidic functional group is not particularly limited, and examples include a carboxy group (-COOH), a sulfo group (sulfonic acid group) (-SO3H), a phosphonic acid group [-P(=O)(OH)2], a phosphoric acid group [-OPO(OH)2], etc. Since the allergen reducing agent has an excellent allergen reducing effect, a carboxy group, a sulfo group, and a phosphonic acid group are preferred.

[0038] The salt of the carboxy group (-COOH) is not particularly limited, and examples include a sodium salt (-COONa), a potassium salt (-COOK), a calcium salt [(-COO - )2Ca 2+ , an ammonium salt (-COO - NH4 + ), a magnesium salt [(-COO - )2Mg 2+ , a barium salt [(-COO - )2Ba 2+ , etc. The sodium salt is preferred.

[0039] The salt of the sulfo group (-SO3H) is not particularly limited, and examples include a sodium salt (-SO3Na), a potassium salt (-SO3K), a calcium salt [(-SO3 - )2Ca 2+ , an ammonium salt (-SO3- NH4 + ), magnesium salt [(-SO3 - )2Mg 2+ ], barium salt [(-SO3 - )2Ba 2+ Examples include ], with sodium salts being preferred.

[0040] The salts of the phosphonic acid group [-P(=O)(OH)2] are not particularly limited, and include, for example, sodium salt [-P(=O)(ONa)2], potassium salt [-P(=O)(OK)2], and calcium salt [-P(=O)(OH)2]. - ) 2Ca 2+ ], ammonium salt [-P (=O) (O - NH4 + )2], magnesium salt [-P(=O)(O - ) 2Mg 2+ ], barium salt [-P (=O) (O - ) 2Ba 2+ These are some examples.

[0041] The salts of the phosphate group [-OPO(OH)2] are not particularly limited, and include, for example, sodium salt [-OPO(ONa)2], potassium salt [-OPO(OK)2], calcium salt [-OPO(O - ) 2Ca 2+ ], ammonium salt [-OPO(O - NH4 + )2], magnesium salt [-OPO(O - ) 2Mg 2+ ], barium salt [-OPO(O - ) 2Ba 2+ These are some examples.

[0042] Acidic compounds having a carboxyl group or a salt thereof only need to have one or more carboxyl groups or salts thereof in their molecule, for example, citric acid, oxalic acid, lactic acid, tartaric acid, malic acid, adipic acid, benzoic acid, lauric acid, azelaic acid, sebacic acid, dodecanediic acid, fumaric acid, phthalic acid, isophthalic acid, terephthalic acid, methylenedisalicylic acid, cis-Δ4-tetrahydrophthalic acid, caproic acid, enanthic acid, caprylic acid, pelargonic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, myristoleic acid, oleic acid, ricinic acid Examples include lactic acid, salicylic acid, gallic acid hydrate, benzyl acid, 4-aminobenzoic acid, triglycolamic acid, ethylenediaminetetraacetic acid, 1,3-diaminopropanetetraacetic acid, ethylenediaminesuccinic acid, diethylenetriaminepentaacetic acid, 1-amino-1-cyclobutanecarboxylic acid, cycloleucine, 1-aminocyclohexanecarboxylic acid, 3-aminocyclohexanecarboxylic acid, polymers having carboxyl groups in the side chains of linear polymers (for example, polyacrylic acid), or salts of these compounds. Citric acid, oxalic acid, lactic acid, tartaric acid, and malic acid are preferred.

[0043] In polymers having a carboxyl group or a salt thereof in the side chain of a linear polymer, the linear polymer is not particularly limited, but for example, vinyl polymers, polyesters, and polyurethanes are preferred, and vinyl polymers are more preferred.

[0044] Examples of polymers having carboxyl groups in the side chains of linear polymers include polymers containing carboxyl group-containing monomers as monomer units. A polymer containing carboxyl group-containing monomers as monomer units may be a homopolymer of carboxyl group-containing monomers, or a copolymer of a carboxyl group-containing monomer and a monomer copolymerizable thereto.

[0045] The carboxyl group-containing monomer is not particularly limited, and examples include acrylic acid, methacrylic acid, β-carboxyethyl (meth)acrylate, 5-carboxypentyl (meth)acrylate, mono(meth)acryloyloxyethyl succinate, ω-carboxypolycaprolactone mono(meth)acrylate, crotonic acid, maleic acid, fumaric acid, itaconic acid, citraconic acid, and carboxybetaine-type monomers, with acrylic acid and methacrylic acid being preferred. The carboxyl group-containing monomer may be used alone or in combination of two or more types.

[0046] Examples of polymers having a carboxyl group salt in the side chain of a linear polymer include polymers containing a carboxyl group salt-containing monomer as monomer units. A polymer containing a carboxyl group salt-containing monomer as monomer units may be a homopolymer of carboxyl group salt-containing monomers, or a copolymer of a carboxyl group salt-containing monomer and a monomer copolymerizable thereto.

[0047] The monomers containing a carboxyl group salt are not particularly limited, and examples include salts of acrylic acid, salts of methacrylic acid, salts of mono(meth)acryloyloxyethyl succinate, salts of ω-carboxypolycaprolactone mono(meth)acrylate, salts of crotonic acid, salts of maleic acid, salts of fumaric acid, salts of itaconic acid, salts of citraconic acid, and salts of carboxybetaine-type monomers. Salts of acrylic acid are preferred, and sodium acrylate and potassium acrylate are more preferred. The monomers containing a carboxyl group salt may be used alone or in combination of two or more.

[0048] Acidic compounds containing a sulfo group (-SO3H) or a salt thereof only need to have one or more sulfo groups or salts thereof in the molecule. Examples include polymers having a sulfo group or a salt thereof in the side chain of a linear polymer, polystyrene sulfonic acid or its sulfonate, sulfonated (styrene-divinylbenzene copolymer) or its sulfonate, sulfonated polyethersulfone or its sulfonate.

[0049] In polymers having a sulfo group or a salt thereof in the side chain of a linear polymer, the linear polymer is not particularly limited, but for example, vinyl polymers, polyesters, and polyurethanes are preferred, and vinyl polymers are more preferred.

[0050] Examples of polymers having sulfo groups in the side chains of linear polymers include polymers containing sulfo group-containing monomers as monomer units.

[0051] Examples of polymers containing sulfo group-containing monomers as monomer units include polymers containing styrene sulfonic acid units, homopolymers of styrene sulfonic acid, styrene-styrene sulfonic acid copolymers, compounds in which the benzene ring of polystyrene is sulfonated, and compounds in which the benzene ring of a polymer containing a styrene component is sulfonated.

[0052] The monomers containing sulfo groups are not particularly limited, and examples include p-styrenesulfonic acid, m-styrenesulfonic acid, and o-styrenesulfonic acid.

[0053] Polymers having a sulfo salt in the side chain of a linear polymer are not particularly limited, and examples include polymers containing a sulfo salt-containing monomer containing a sulfo salt as a monomer unit.

[0054] Polymers containing a sulfo group salt-containing monomer as a monomer unit include, for example, polymers containing styrene sulfonate units, homopolymers of styrene sulfonate, styrene-styrene sulfonate copolymers, sulfonate salts of compounds in which the benzene ring of polystyrene is sulfonated, and sulfonate salts of compounds in which the benzene ring of a polymer containing a styrene component is sulfonated.

[0055] The monomer containing a sulfo group salt is not particularly limited, and examples include sodium p-styrenesulfonate, sodium m-styrenesulfonate, sodium o-styrenesulfonate, calcium p-styrenesulfonate, calcium m-styrenesulfonate, calcium o-styrenesulfonate, ammonium p-styrenesulfonate, ammonium m-styrenesulfonate, and ammonium o-styrenesulfonate. Sodium styrenesulfonate is preferred, and sodium p-styrenesulfonate is more preferred because it exhibits less steric hindrance in reactivity with allergens.

[0056] Acidic compounds containing a sulfo group salt only need to have one or more sulfo group salts in their molecule. Examples include linear alkylbenzene sulfonates, α-olefin sulfonates, alkyldiphenyl ether sulfonates, polyoxyalkylene alkyl ether sulfates, polymers having sulfo group salts in the side chains of linear polymers, salts of polystyrene sulfonic acid, salts of sulfonated (styrene-divinylbenzene copolymers), and salts of sulfonated polyethersulfones.

[0057] As acidic compounds containing a sulfo group or a salt thereof, acidic compounds containing a benzene ring having a hydroxyl group and a sulfo group as substituents, and acidic compounds containing a benzene ring having a salt of a hydroxyl group and a sulfo group as substituents are preferred, and acidic compounds having the structures shown in the following formulas (1) to (3) are more preferred. The allergen reducing agent exhibits excellent water resistance in its allergen reducing effect.

[0058]

[0059] However, in equation (1), X 1 X is a countercation that becomes a hydrogen ion or a salt. In equation (2), X 2 X is a countercation that becomes a hydrogen ion or a salt. In equation (3), X 3 This is a countercation that becomes a hydrogen ion or a salt.

[0060] In equation (1), X 1Examples include hydrogen ions, sodium ions, and potassium ions, with hydrogen ions and sodium ions being preferred. In formula (1), -SO3X 1 It is preferable that the compound is located at the meta or para position relative to the hydroxyl group (-OH). The allergen-reducing effect of the allergen-reducing agent has excellent water resistance.

[0061] In equation (2), X 2 Examples of such ions include hydrogen ions, sodium ions, and potassium ions, with potassium ions and sodium ions being preferred.

[0062] In equation (3), X 3 Examples of such ions include hydrogen ions, sodium ions, and potassium ions, with potassium ions and sodium ions being preferred.

[0063] The acidic compound containing a sulfo group or a salt thereof preferably has the structure shown in formula (4a), and more preferably has the structure shown in formula (4b). The allergen-reducing effect of the allergen-reducing agent has excellent water resistance.

[0064]

[0065] In equations (4a) and (4b), n is the number of repeating units and is an integer of 2 or more, X 4 X is a countercation that becomes a hydrogen ion or a salt. 5 is a countercation that becomes a hydrogen ion or a salt. *1 is a bonding hand and means a single bond.

[0066] X 4 This is a countercation that becomes a hydrogen ion or a salt. The countercation that becomes a salt is not particularly limited, and examples include sodium ions, potassium ions, calcium ions, ammonium ions, magnesium ions, and barium ions, with sodium ions and potassium ions being preferred.

[0067] X 5The countercation is either a hydrogen ion or a salt, with hydrogen ions being preferred. The salt-forming countercation is not particularly limited and includes, for example, sodium ions, potassium ions, calcium ions, ammonium ions, magnesium ions, and barium ions, with sodium ions and potassium ions being preferred.

[0068] The acidic compound having the structure shown in formula (4a) is preferably also having the structure shown in formula (5).

[0069]

[0070] In equation (5), m is the number of repeating units and is an integer of 2 or more. 6 X is a countercation that becomes a hydrogen ion or a salt. 6 These may be identical or different from one another. *2 is a bonding term and signifies a single bond.

[0071] X 6 The countercation is either a hydrogen ion or a salt, with hydrogen ions being preferred. The salt-forming countercation is not particularly limited and includes, for example, sodium ions, potassium ions, calcium ions, ammonium ions, magnesium ions, and barium ions, with sodium ions and potassium ions being preferred.

[0072] As the acidic compound, polymers having the structural unit shown in formula (6a) are preferred, polymers having the structural unit shown in formula (6b) are more preferred, polymers shown in formula (6c) are more preferred, and polymers shown in formula (6d) are more preferred. The allergen reducing effect of the allergen reducing agent has excellent water resistance.

[0073]

[0074]

[0075] In equations (6a) to (6d), n is the number of repeating units and is an integer of 2 or more, and m is the number of repeating units and is an integer of 2 or more. 4 X is a countercation that becomes a hydrogen ion or a salt. 5X is a countercation that becomes a hydrogen ion or a salt. 6 X is a countercation that becomes a hydrogen ion or a salt. 6 These may be identical or different from one another. *3 is a bonding term and signifies a single bond.

[0076] In equations (6a) to (6d), X 4 It is preferable that is a sodium ion or a potassium ion. In formulas (6a) to (6d), X 5 It is preferable that is a hydrogen ion. In formulas (6a) to (6d), X 6 It is preferable that it be a hydrogen ion.

[0077] In this invention, the structural formula shown in formula (7) below represents a random copolymer, alternating copolymer, or block copolymer of monomer units M1 and M2. d, e, and f indicate the number of repeating units and are integers of 2 or more.

[0078]

[0079] Acidic compounds having a phosphonic acid group [-P(=O)(OH)2] only need to have one or more phosphonic acid groups in the molecule. Examples include 1-hydroxyethane-1,1-diphosphonic acid, N,N,N',N'-ethylenediaminetetrakis (methylenephosphonic acid), 2-phosphonobutane-1,2,4-tricarboxylic acid, nitrilotris (methylenephosphonic acid), and polymers having phosphonic acid groups in the side chains of linear polymers.

[0080] In polymers having phosphonic acid groups in the side chains of linear polymers, the linear polymer is not particularly limited, but for example, vinyl polymers, polyesters, and polyurethanes are preferred, and vinyl polymers are more preferred.

[0081] Examples of polymers having phosphonic acid groups in the side chains of linear polymers include polymers containing phosphonic acid group-containing monomers as monomer units. A polymer containing phosphonic acid group-containing monomers as monomer units may be a homopolymer of phosphonic acid group-containing monomers, or a copolymer of a phosphonic acid group-containing monomer and a monomer copolymerizable therewith.

[0082] The monomer containing the phosphonic acid group is not particularly limited, and examples include [3-(acryloyloxy)propyl]phosphonic acid. The monomer containing the phosphonic acid group may be used alone or in combination of two or more types.

[0083] Acidic compounds containing a phosphonic acid salt only need to have one or more phosphonic acid salts in their molecule. Examples include ethylenediaminetetramethylenephosphonate pentasodium, alkylphosphonate sodium, alkylbenzenephosphonate sodium, and polymers having a phosphonic acid salt in the side chain of a linear polymer.

[0084] In polymers having a phosphonic acid salt in the side chain of a linear polymer, the linear polymer is not particularly limited, but vinyl polymers, polyesters, and polyurethanes are preferred, with vinyl polymers being more preferred.

[0085] Examples of polymers having a phosphonic acid salt in the side chain of a linear polymer include polymers containing a phosphonic acid salt-containing monomer as a monomer unit. A polymer containing a phosphonic acid salt-containing monomer as a monomer unit may be a homopolymer of the phosphonic acid salt-containing monomer, or a copolymer of a phosphonic acid salt-containing monomer and a monomer copolymerizable thereto.

[0086] Acidic compounds having a phosphate group or a salt thereof only need to have one or more phosphonic acid groups in the molecule, and examples include (di)alkyl phosphate esters, (di)polyoxyalkylene alkyl ether phosphate esters, polyoxyalkylene alkylaryl ether phosphate esters, or salts of these compounds.

[0087] Polymers having at least one acidic functional group selected from the group consisting of carboxyl groups (-COOH), sulfo groups (-SO3H), phosphonic acid groups [-P(=O)(OH)2] and phosphate groups [-OPO(OH)2], or a salt thereof, in the side chains of linear polymers can be produced by general methods, for example: (1) a method of radical polymerization of a monomer having an acidic functional group or a salt thereof; (2) a method of radical polymerization of a monomer having an acidic functional group or a salt thereof with a monomer copolymerizable with this monomer; and (3) a method of neutralizing the acidic functional group of a polymer containing a monomer component having an acidic functional group using an alkali (e.g., sodium hydroxide, calcium hydroxide, potassium hydroxide, ammonium hydroxide, etc.).

[0088] When the acidic compound is a polymer, the weight-average molecular weight of the acidic compound is preferably 2000 or more, more preferably 5000 or more, and more preferably 10000 or more. The weight-average molecular weight of the acidic compound is preferably 250000 or less, more preferably 100000 or less, more preferably 50000 or less, more preferably 30000 or less, and more preferably 20000 or less. When the acidic compound is a polymer, the weight-average molecular weight of the acidic compound is preferably 2000 to 250000, more preferably 5000 to 100000, more preferably 5000 to 50000, more preferably 5000 to 30000, and more preferably 5000 to 20000. When the weight-average molecular weight of the acidic compound is 2000 or more, the sulfo group or its salt bonded to the aromatic ring can be arranged in a linked state with the hydroxyl group or its salt, allowing for effective interaction with the allergen. Therefore, allergen reducing agents exhibit superior allergen reduction effects. When the weight-average molecular weight of the acidic compound is 250,000 or less, the allergen reducing effect of the allergen reducing agent has excellent water resistance.

[0089] In this invention, the weight-average molecular weight of the polymer is the polystyrene-converted value measured by GPC (gel permeation chromatography). When multiple peak tops are detected by GPC, the area value of each peak is considered as a weight to calculate the weight-average molecular weight, and this value is taken as the weight-average molecular weight of the polymer.

[0090] For example, measurements can be taken using the following measuring device and conditions: Gel permeation chromatograph: Waters Corporation product name "Alliance HPLC" Column: Resonaq Corporation product name "OHpak SB-805" Detector: Differential refractometer Sample flow rate: 1 mL / min Column temperature: 40°C Elutate: 0.2 M Na2CO3 aq. 60 vol% / acetonitrile 40 vol%

[0091] The content of the acidic compound in the allergen reducing agent is preferably 0.5 parts by mass or more, more preferably 1 part by mass or more, more preferably 3 parts by mass or more, more preferably 5 parts by mass or more, more preferably 7 parts by mass or more, more preferably 10 parts by mass or more, more preferably 30 parts by mass or more, more preferably 50 parts by mass or more, more preferably 70 parts by mass or more, and more preferably 90 parts by mass or more, per 100 parts by mass of the niobium compound. The content of the acidic compound in the allergen reducing agent is preferably 300 parts by mass or less, more preferably 200 parts by mass or less, more preferably 150 parts by mass or less, more preferably 120 parts by mass or less, and more preferably 110 parts by mass or less, per 100 parts by mass of the niobium compound. The content of the acidic compound in the allergen reducing agent is preferably 0.5 to 300 parts by mass, more preferably 1 to 200 parts by mass, more preferably 5 to 150 parts by mass, and more preferably 30 to 120 parts by mass, per 100 parts by mass of the niobium compound. When the acidic compound is present in amounts of 10 parts by mass or more, the allergen-reducing effect of the allergen-reducing agent exhibits excellent water resistance. When the acidic compound is present in amounts of 300 parts by mass or less, a cross-linked structure can be formed by dehydrating and condensing some of the hydroxyl groups of the niobium compound while retaining some of them, thereby imparting an excellent allergen-reducing effect to the allergen-reducing agent, and this allergen-reducing effect exhibits excellent water resistance.

[0092] (Binder Resin) The allergen reducing agent may contain a binder resin. The binder resin is not particularly limited as long as it can fix the allergen reducing agent to the surface of the substrate. Examples of binder resins include urethane resins such as one-component urethane resins and two-component urethane resins, silicone resins, acrylic resins, urethane acrylate resins, polyester resins, unsaturated polyester resins, alkyd resins, vinyl acetate resins, vinyl chloride resins, epoxy resins, epoxy acrylate resins, and other synthetic resin binder resins, with urethane resins and polyester resins being preferred. It is preferable that the binder resin does not have an acidic functional group or a salt thereof in its molecule.

[0093] The binder resin content in the allergen reducing agent is preferably 10 parts by mass or more, more preferably 30 parts by mass or more, more preferably 50 parts by mass or more, more preferably 70 parts by mass or more, and more preferably 90 parts by mass or more, per 100 parts by mass of niobium compound. The binder resin content in the allergen reducing agent is preferably 3000 parts by mass or less, more preferably 2500 parts by mass or less, more preferably 2000 parts by mass or less, more preferably 1500 parts by mass or less, and more preferably 1000 parts by mass or less, per 100 parts by mass of niobium compound. The binder resin content in the allergen reducing agent is preferably 10 to 3000 parts by mass per 100 parts by mass of niobium compound. When the binder resin content is within the above range, the niobium compound can be adhered more firmly to the surface of the substrate. Even after the substrate on which the niobium compound has been adhered to the surface has been treated with water by washing or the like, the excellent allergen reducing effect is maintained. When the niobium compound contained in the allergen reducing agent is niobium oxide, the surface of the niobium oxide reacts with water to produce niobium oxide with a layer of niobium hydroxide on its surface, thereby improving the allergen reducing effect.

[0094] (Inorganic Oxides) Allergen reducing agents preferably contain inorganic oxides (excluding niobium oxide) (hereinafter sometimes simply referred to as "inorganic oxides") because this improves their allergen reducing effect. Inorganic oxides are not particularly limited and include, for example, titanium dioxide, zinc oxide, iron oxide, aluminum oxide, magnesium oxide, silicon dioxide (silica), and boron oxide. Inorganic oxides may be used alone or in combination of two or more.

[0095] If an allergen reducing agent contains inorganic oxides, its moisture retention capacity improves. If the niobium compound contained in the allergen reducing agent is niobium oxide, the surface of the niobium oxide reacts with water, producing niobium oxide with a layer of niobium hydroxide on its surface, thereby improving the allergen reducing effect.

[0096] The inorganic oxide content in the allergen reducing agent is preferably 0.5 parts by mass or more, more preferably 1.0 part by mass or more, more preferably 2.5 parts by mass or more, and more preferably 2.7 parts by mass or more, per 100 parts by mass of the niobium compound. The inorganic oxide content in the allergen reducing agent is preferably 100 parts by mass or less, more preferably 80 parts by mass or less, more preferably 60 parts by mass or less, more preferably 50 parts by mass or less, and more preferably 40 parts by mass or less, per 100 parts by mass of the niobium compound. The inorganic oxide content in the allergen reducing agent is preferably 0.5 to 100 parts by mass, more preferably 1.0 to 60 parts by mass, and more preferably 2.5 to 40 parts by mass, per 100 parts by mass of the niobium compound. When the inorganic oxide content is 0.5 parts by mass or more, the allergen reducing effect of the allergen reducing agent is improved. When the inorganic oxide content is 100 parts by mass or less, the allergen reducing agent can be uniformly dispersed in the solvent, and the allergen reducing agent can be uniformly incorporated into the substrate. The allergen-reducing product exhibits a uniform allergen-reducing effect. Furthermore, the handling of the allergen reducing agent is improved, and the allergen reducing agent can be uniformly and easily incorporated into the substrate.

[0097] Inorganic oxides are preferably in particulate form. When inorganic oxides are in particulate form, the volume-based D50 particle diameter of the inorganic oxide is preferably 0.005 μm or more, and more preferably 0.01 μm or more. The volume-based D50 particle diameter of the inorganic oxide is preferably 100 μm or less, preferably 10 μm or less, preferably 1 μm or less, and more preferably 0.5 μm or less. When inorganic oxides are in particulate form, the volume-based D50 particle diameter of the inorganic oxide is preferably 0.005 to 100 μm, more preferably 0.01 to 10 μm, and more preferably 0.01 to 1 μm. When the volume-based D50 particle diameter of the inorganic oxide is 0.005 μm or more, the allergen-reducing effect of the allergen-reducing agent is improved. Furthermore, the allergen-reducing agent can be uniformly dispersed in the solvent, and the allergen-reducing agent can be uniformly contained in the substrate. The allergen-reducing product exhibits a uniform allergen-reducing effect. Furthermore, the handling of the allergen reducing agent is improved, and the allergen reducing agent can be uniformly and easily incorporated into the substrate. When the volume-based D50 particle size of the inorganic oxide is 1 μm or less, the allergen reducing agent can be uniformly dispersed in the solvent, and the allergen reducing agent can be uniformly incorporated into the substrate. The allergen-reducing product exhibits a uniform allergen-reducing effect. Furthermore, the handling of the allergen reducing agent is improved, and the allergen reducing agent can be uniformly and easily incorporated into the substrate.

[0098] When the inorganic oxide is in particulate form, the volume-based D90 particle diameter of the inorganic oxide is preferably 0.01 μm or more, and more preferably 0.03 μm or more. The volume-based D90 particle diameter of the inorganic oxide is preferably 200 μm or less, more preferably 20 μm or less, more preferably 2 μm or less, and more preferably 1 μm or less. When the inorganic oxide is in particulate form, the volume-based D90 particle diameter of the inorganic oxide is preferably 0.01 to 200 μm, more preferably 0.03 to 20 μm, and more preferably 0.03 to 2 μm. When the volume-based D90 particle diameter of the inorganic oxide is within the above range, the inclusion of coarse particles in the inorganic oxide is reduced, and the allergen-reducing effect of the allergen-reducing agent is improved. Furthermore, the allergen-reducing agent can be uniformly dispersed in the solvent, and the allergen-reducing agent can be uniformly contained in the substrate. The allergen-reducing product exhibits a more uniform allergen-reducing effect. Furthermore, the handling of the allergen reducing agent is improved, and the allergen reducing agent can be uniformly and easily incorporated into the base material.

[0099] In inorganic oxides, the volume-based D50 particle diameter and D90 particle diameter refer to the particle diameters at which the cumulative frequency (cumulative from smallest particles) in the volume-based particle size distribution measured by laser diffraction and scattering methods reaches 50% and 90%, respectively (50% cumulative particle diameter and 90% cumulative particle diameter). In laser diffraction and scattering measurements, the refractive index of the laser diffraction and scattering particle size distribution analyzer is set to the refractive index corresponding to the inorganic oxide being measured.

[0100] When the inorganic oxide is a fine particle, the particle size of the inorganic oxide may be measured as the particle size based on the scattered light intensity by the dynamic light scattering method. The D50 particle size based on the scattered light intensity of the inorganic oxide is more preferably 0.005 μm or more, more preferably 0.01 μm or more, and more preferably 0.03 μm or more. The D50 particle size based on the scattered light intensity of the inorganic oxide is preferably 100 μm or less, more preferably 10 μm or less, more preferably 5 μm or less, more preferably 1 μm or less, and more preferably 0.5 μm or less. The D50 particle size based on the scattered light intensity of the inorganic oxide is preferably 0.005 to 100 μm, more preferably 0.01 to 10 μm, more preferably 0.01 to 5 μm, and more preferably 0.01 to 1 μm. When the D50 particle size based on the scattered light intensity of the inorganic oxide is 0.005 μm or more, the allergen reducing effect of the allergen reducing agent is improved. Furthermore, the allergen reducing agent can be uniformly dispersed in the solvent, and the allergen reducing agent can be uniformly incorporated into the substrate. The allergen-reducing product exhibits a uniform allergen-reducing effect. In addition, the handling of the allergen reducing agent is improved, and the allergen reducing agent can be uniformly and easily incorporated into the substrate. If the D50 particle size, based on the scattered light intensity of inorganic oxides, is 100 μm or less, the allergen reducing agent can be uniformly dispersed in the solvent, and the allergen reducing agent can be uniformly incorporated into the substrate. The allergen-reducing product exhibits a uniform allergen-reducing effect. In addition, the handling of the allergen reducing agent is improved, and the allergen reducing agent can be uniformly and easily incorporated into the substrate.

[0101] When the inorganic oxide consists of fine particles, the D90 particle diameter based on scattered light intensity in the inorganic oxide is more preferably 0.01 μm or larger, more preferably 0.03 μm or larger, and more preferably 0.05 μm or larger. The D90 particle diameter based on scattered light intensity in the inorganic oxide is more preferably 200 μm or less, more preferably 20 μm or less, more preferably 2 μm or less, more preferably 1 μm or less, and more preferably 0.7 μm or less. The D90 particle diameter based on scattered light intensity in the inorganic oxide is more preferably 0.01 to 200 μm, more preferably 0.05 to 20 μm, and more preferably 0.05 to 2 μm. When the D90 particle diameter based on scattered light intensity in the inorganic oxide is within the above range, the inclusion of coarse particles in the inorganic oxide is reduced, and the allergen reducing effect of the allergen reducing agent is improved. Furthermore, the allergen reducing agent can be uniformly dispersed in the solvent, and the allergen reducing agent can be uniformly contained in the substrate. Allergen-reducing products exhibit a more uniform allergen-reducing effect. Furthermore, the handling of the allergen-reducing agent is improved, allowing for uniform and easy incorporation of the allergen-reducing agent into the base material.

[0102] Furthermore, the D50 and D90 particle diameters based on scattered light intensity for inorganic oxides refer to the particle diameters at which the cumulative frequency in the particle size distribution based on scattered light intensity by dynamic light scattering methods reaches 50% and 90%, respectively. Measurement by dynamic light scattering can be performed using a light scattering measuring device (for example, "ZETASIZER NANO-S" manufactured by Malvern). The light scattering measuring device is prepared by adjusting the aqueous dispersion so that the concentration of the inorganic oxide is 0.1% by mass, and the refractive index is set to the refractive index corresponding to the inorganic oxide being measured. In addition, the D50 and D90 particle diameters based on scattered light intensity can be converted to volume-based D50 and D90 particle diameters by assuming that the particles are perfectly spherical.

[0103] [Allergen Reducing Agents] Allergen reducing agents have an allergen-reducing effect against various allergens through the action of niobium compounds.

[0104] Allergens targeted by allergen reducing agents include animal allergens such as dust mite allergens (Der1, Der2), allergens caused by dogs and cats (Can f1, Fel d1), and plant allergens such as cedar pollen allergens (Cryj1, Cryj2) and pollen that float in the air. While any type of mite allergen can be targeted, particularly those found in indoor dust, especially bedding, and are a common cause of allergic diseases, this product is especially effective against house dust mites, particularly house dust mites, which are abundant in bedding and are a major cause of allergic diseases.

[0105] Here, an allergen reducing agent refers to a substance that has an allergen reducing effect. The allergen reducing effect can be determined by measuring the allergen reduction rate of cedar pollen allergen (Cryj1) or dust mite allergen (Derf1) in the following manner, and if the allergen reduction rate for at least one of the allergens is 60% or higher, it can be determined that the substance has an allergen reducing effect.

[0106] The allergen-reducing effect of an allergen-reducing agent is measured, for example, in the following manner: An allergen-reducing coating is prepared by adding 90 parts by mass of binder resin as solid content to 10 parts by mass of allergen-reducing agent. Next, a polyester film is prepared as a substrate. After coating one side of this substrate with the allergen-reducing coating, the coating is dried or cured to produce an allergen-reducing product in which a coating film with a thickness of 18 μm is formed on one side.

[0107] Each of the above allergens is dissolved separately in purified water to prepare an allergen aqueous solution containing 10 μg / mL of the allergen. Then, 0.05 w / v% polysorbate 20-containing phosphate-buffered saline (pH: 7.4, hereinafter referred to as "PBS-T") is added to the allergen aqueous solution and mixed uniformly to prepare an allergen solution containing 15 ng / mL of the allergen.

[0108] The above allergen-reducing product is cut into a flat square with sides of 5 cm, 0.4 mL of the above allergen solution is dropped onto the coating film, and then the product is covered with a flat square polyethylene film with sides of 4 cm and left at 25°C for 24 hours to prepare the test solution. Next, the amount of allergen W1 (ng / mL) in the test solution is measured using the above measuring reagent.

[0109] A blank product with a coating formed on one side is prepared in the same manner as above, except that a binder resin is used as the blank coating instead of the allergen-reducing coating. The amount of allergen W0 (ng / mL) present in the test solution is measured in the same manner as above, except that a blank product is used instead of the allergen-reducing product. The allergen reduction rate (%) is calculated based on the following formula: Allergen reduction rate (%) = 100 - (W1 / W0) × 100

[0110] For example, as the cedar pollen allergen (Cryj1), you can use the product commercially available from ITEA under the product name "Cedar Pollen Extract, Code 4-CJ-001". As the dust mite allergen (Derf1), you can use the product commercially available from ITEA under the product name "Dust Mite Allergen Extract, Code 4-DF-001".

[0111] The allergen reduction rate of the allergen reducing agent is preferably 70% or more, more preferably 80% or more, more preferably 85% or more, more preferably 90% or more, and more preferably 95% or more.

[0112] The method for producing an allergen reducing agent is not particularly limited. For example, an allergen reducing agent can be produced by mixing a niobium compound, which is the active ingredient, with a general-purpose additive as needed, in a general manner.

[0113] This document explains the usage instructions for allergen reducing agents. Allergen reducing agents exert an allergen-reducing effect against various allergens through the action of niobium compounds. Allergen reducing agents can reduce allergens by inactivating them upon contact.

[0114] Allergen reducing agents are used, for example, by being incorporated into a substrate to which an allergen reducing effect is desired, thereby constituting an allergen-reducing product. A substrate containing an allergen reducing agent exhibits an allergen-reducing effect as an allergen-reducing product. The form in which the allergen reducing agent is incorporated into the substrate is not particularly limited, and examples include mixing the allergen reducing agent into the substrate, attaching the allergen reducing agent to the surface of the substrate, or kneading the allergen reducing agent into the substrate.

[0115] By dispersing an allergen-reducing agent in a solvent to form an allergen-reducing solution, and then coating this allergen-reducing solution onto a substrate, the allergen-reducing agent can be adhered to the substrate surface. The allergen-reducing solution may also contain additives such as oils, emulsions, and suspensions, as needed.

[0116] Examples of the solvents mentioned above include water (preferably deionized water), alcohols (methyl alcohol, ethyl alcohol, propyl alcohol, etc.), hydrocarbons (toluene, xylene, methylnaphthalene, kerosene, cyclohexane, etc.), ethers (diethyl ether, tetrahydrofuran, dioxane, etc.), ketones (acetone, methyl ethyl ketone, etc.), and amides (N,N-dimethylformamide, etc.), with water being preferred.

[0117] The content of the allergen reducing agent in 100% by mass of the allergen reducing solution is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and more preferably 1% by mass or more. The content of the allergen reducing agent in 100% by mass of the allergen reducing solution is preferably 20% by mass or less, more preferably 15% by mass or less, and more preferably 10% by mass or less. The content of the allergen reducing agent in 100% by mass of the allergen reducing solution is preferably 0.01 to 20% by mass, more preferably 0.1 to 15% by mass, and more preferably 1 to 10% by mass. When the allergen reducing agent is 0.01% by mass or more, an excellent allergen reducing effect can be imparted to the substrate. When the allergen reducing agent is 20% by mass or less, the niobium compound can be uniformly dispersed in the allergen reducing solution, a film formed from the niobium compound can be uniformly formed on the surface of the substrate, and an excellent allergen reducing effect can be uniformly imparted to the substrate.

[0118] The content of niobium compounds in 100% by mass of the allergen-reducing solution is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and more preferably 1% by mass or more. The content of niobium compounds in 100% by mass of the allergen-reducing solution is preferably 20% by mass or less, more preferably 15% by mass or less, and more preferably 10% by mass or less. The content of niobium compounds in 100% by mass of the allergen-reducing solution is preferably 0.01 to 20% by mass, more preferably 0.1 to 15% by mass, and more preferably 1 to 10% by mass. When the niobium compound content is 0.01% by mass or more, the substrate can be imparted with an excellent allergen-reducing effect. When the niobium compound content is 20% by mass or less, the niobium compound can be uniformly dispersed in the allergen-reducing solution, a film formed from the niobium compound can be uniformly formed on the surface of the substrate, and the substrate can be uniformly imparted with an excellent allergen-reducing effect.

[0119] When an allergen reducing agent is dispersed in a solvent to form an allergen reducing solution, it is preferable that the allergen reducing solution contains an ammonium compound. The presence of an ammonium compound in the allergen reducing solution improves the adhesion of the niobium compound to the substrate, allowing the niobium compound to adhere more firmly to the substrate surface.

[0120] The ammonium compound is not particularly limited and examples include ammonia and ammonium salts. The ammonium compound may be used alone or in combination of two or more types.

[0121] Examples of ammonium salts include tetramethylammonium hydroxide, tetraisopropylammonium hydroxide, tetrabutylammonium hydroxide, tetrahexylammonium hydroxide, tetraoctylammonium hydroxide, phenyltrimethylammonium hydroxide, 3-(trifluoromethyl)phenyltrimethylammonium hydroxide, and tetra-n-butylammonium salicylate.

[0122] The content of ammonium compounds in the allergen-reducing solution is preferably 1 part by mass or more, more preferably 2 parts by mass or more, and more preferably 3 parts by mass or more, per 100 parts by mass of niobium compound. The content of ammonium compounds in the allergen-reducing solution is preferably 35 parts by mass or less, more preferably 25 parts by mass or less, more preferably 15 parts by mass or less, and more preferably 10 parts by mass or less, per 100 parts by mass of niobium compound. The content of ammonium compounds is preferably 1 to 35 parts by mass, more preferably 2 to 25 parts by mass, and more preferably 3 to 15 parts by mass, per 100 parts by mass of niobium compound. When the content of ammonium compounds is within the above range, the adhesion of niobium compound to the substrate is improved.

[0123] If the allergen-reducing solution contains a compound that undergoes a neutralization reaction with ammonia to produce a salt, and the salt is dissolved in water, then the allergen-reducing solution is considered to contain the compound that served as the raw material for the salt and ammonia.

[0124] The allergen-reducing solution preferably contains a film-forming aid. When the allergen-reducing solution contains a film-forming aid, the adhesion of the niobium compound to the substrate is improved, allowing the niobium compound to adhere more firmly to the substrate surface.

[0125] The film-thickening agent is not particularly limited, and examples include polyvinyl alcohol. Preferably, the film-thickening agent does not contain a carboxyl group (-COOH), a sulfo group (sulfonic acid group) (-SO3H), a phosphonic acid group [-P(=O)(OH)2], or a phosphate group [-OPO(OH)2] in its molecule.

[0126] The allergen-reducing solution may contain a binder resin. The binder resin is the same as that described for the allergen-reducing agent, so its description is omitted.

[0127] The binder resin content in the allergen-reducing solution is preferably 10 parts by mass or more, more preferably 30 parts by mass or more, more preferably 50 parts by mass or more, more preferably 70 parts by mass or more, and more preferably 90 parts by mass or more, per 100 parts by mass of niobium compound. The binder resin content in the allergen-reducing solution is preferably 3000 parts by mass or less, more preferably 2500 parts by mass or less, more preferably 2000 parts by mass or less, more preferably 1500 parts by mass or less, and more preferably 1000 parts by mass or less, per 100 parts by mass of niobium compound. The binder resin content in the allergen-reducing solution is preferably 10 to 3000 parts by mass per 100 parts by mass of niobium compound. When the binder resin content is within the above range, the niobium compound can be adhered more firmly to the surface of the substrate, and the excellent allergen-reducing effect is maintained even after the substrate with the niobium compound adhered to its surface has been treated with water by washing or the like. When the niobium compound contained in the allergen reduction solution is niobium oxide, the surface of the niobium oxide reacts with water to produce niobium oxide with a layer of niobium hydroxide on its surface, thereby improving the allergen reduction effect.

[0128] The turbidity of the allergen-reducing solution is preferably 10 or higher, more preferably 20 or higher, and even more preferably 30 or higher. The turbidity of the allergen-reducing solution is preferably 800 or lower, more preferably 600 or lower, and even more preferably 400 or lower. By setting the turbidity of the allergen-reducing solution within the above range, the amount of hydroxyl groups present on the surface of particulate niobium compounds in the allergen-reducing product manufactured using the allergen-reducing solution can be more appropriately adjusted, thereby achieving an even better allergen-reducing effect.

[0129] The turbidity of the allergen-reducing solution is measured using a turbidimeter (for example, AS ONE product name "TBD-700") placed in a cylindrical glass sample tube with a diameter of 24 mm.

[0130] The substrates for which the allergen reducing agent is contained are not particularly limited as long as they can contain the allergen reducing agent, and examples include synthetic resin molded articles, paints, wallpaper, decorative sheets, flooring materials, fibers, textile products (woven fabrics, nonwoven fabrics, knitted fabrics), interior accessories and interior materials for vehicles (e.g., cars, airplanes, ships, etc.) (seats, child seats and the foams that make them up, etc.), kitchenware, baby products, and building interior materials.

[0131] The synthetic resin constituting the molded synthetic resin article is not particularly limited and includes, for example, thermoplastic resins (e.g., polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyvinyl acetate, polyurethane, Teflon®, acrylonitrile butadiene styrene resin, acrylonitrile styrene resin, acrylic resin, polyvinyl alcohol, polyamide, polyacetal, polycarbonate, modified polyphenylene ether, polyester, polyethylene terephthalate, polybutylene terephthalate, cyclic polyolefin, polyphenylene sulfide, polytetrafluoroethylene, polysulfone, polyethersulfone, polyarylate, polyetheretherketone, thermoplastic polyimide, polyamideimide, etc.) and thermosetting resins (e.g., phenolic resin, epoxy resin, melamine resin, urea resin, unsaturated polyester resin, alkyd resin, silicone resin, polyurethane, thermosetting polyimide, etc.). The synthetic resin may be used alone or in combination of two or more types.

[0132] The allergen reducing agent may be kneaded into the synthetic resin. One method of kneading the allergen reducing agent into the synthetic resin is to mix the allergen reducing agent with the raw material synthetic resin to create a resin composition. Using this resin composition, an allergen-reducing product of the desired shape can be obtained as a molded article by a general-purpose synthetic resin molding method. Examples of general-purpose synthetic resin molding methods include extrusion molding, injection molding, and blow molding. Alternatively, the synthetic resin and the allergen reducing agent may be mixed to form a masterbatch for synthetic resin molding, which can then be mixed with the raw material synthetic resin to produce a molded allergen-reducing product using a general-purpose synthetic resin molding method.

[0133] The content of the allergen reducing agent in 100% by mass of the resin composition is preferably 1% by mass or more, more preferably 3% by mass or more, and more preferably 5% by mass or more. The content of the allergen reducing agent in 100% by mass of the resin composition is preferably 20% by mass or less, more preferably 15% by mass or less, and more preferably 10% by mass or less. The content of the allergen reducing agent in 100% by mass of the resin composition is preferably 1 to 20% by mass.

[0134] The content of niobium compounds in 100% by mass of the resin composition is preferably 1% by mass or more, more preferably 3% by mass or more, and more preferably 5% by mass or more. The content of niobium compounds in 100% by mass of the resin composition is preferably 20% by mass or less, more preferably 15% by mass or less, and more preferably 10% by mass or less. The content of niobium compounds in 100% by mass of the resin composition is preferably 1 to 20% by mass.

[0135] The content of the allergen reducing agent in 100% by mass of the masterbatch for molding synthetic resin is preferably 20% by mass or more, more preferably 30% by mass or more, and more preferably 50% by mass or more. The content of the allergen reducing agent in 100% by mass of the masterbatch for molding synthetic resin is preferably 80% by mass or less, more preferably 70% by mass or less, and more preferably 60% by mass or less. The content of the allergen reducing agent in 100% by mass of the masterbatch for molding synthetic resin is preferably 20 to 80% by mass.

[0136] The content of niobium compounds in 100% by mass of a masterbatch for molding synthetic resins is preferably 20% by mass or more, more preferably 30% by mass or more, and even more preferably 50% by mass or more. The content of niobium compounds in 100% by mass of a masterbatch for molding synthetic resins is preferably 80% by mass or less, more preferably 70% by mass or less, and even more preferably 60% by mass or less. The content of niobium compounds in 100% by mass of a masterbatch for molding synthetic resins is preferably 20 to 80% by mass.

[0137] In allergen-reducing products, the presence or absence of an allergen-reducing agent can be confirmed by X-ray fluorescence measurement. When allergen-reducing products are measured by X-ray fluorescence, a peak at around 16.7 keV appears, attributed to niobium compounds. The presence of this peak confirms that the allergen-reducing product contains an allergen-reducing agent. This confirms that the allergen-reducing product exhibits an allergen-reducing effect.

[0138] The method for measuring allergen-reduced products using X-ray fluorescence is as follows: Using an energy-dispersive X-ray fluorescence analyzer (for example, Shimadzu Corporation's product name "EDX8100"), the collimator is set to 10 mm and the X-ray intensity of the Kα rays from niobium atoms in the allergen-reduced product is measured under the conditions of an acceleration voltage of 50 kV, an acceleration current of 1 mA, and an integration time of 60 seconds.

[0139] [Allergen-reducing fibers (textile products)] Allergen-reducing fibers include fibers and the allergen-reducing agent present on the surface of the fibers. That is, allergen-reducing fibers include fibers and the niobium compound present on the surface of the fibers. Allergen-reducing fibers have an allergen-reducing effect against various allergens due to the action of the niobium compound.

[0140] This section describes a method for producing allergen-reducing fibers by physically fixing an allergen-reducing agent to fibers. Examples of methods for physically fixing an allergen-reducing agent to fibers include: (1) dispersing the allergen-reducing agent in a solvent (preferably water) to prepare an allergen-reducing solution, impregnating the fibers in this solution, and fixing the allergen-reducing agent to the fibers; (2) applying or spraying the above allergen-reducing solution onto the fiber surface; (3) immersing the fibers in a binder resin containing the above allergen-reducing agent, and fixing the allergen-reducing agent to the fibers with the binder resin; and (4) applying or spraying the above allergen-reducing agent in a binder resin onto the fiber surface, and fixing the allergen-reducing agent to the fibers with the binder resin. Allergen-reducing fiber products can be produced by using textile products as the fibers. Furthermore, in the methods described in (1) and (2) above, a binder resin may be included in the allergen reduction solution. The solvent is the same as described above, so its explanation is omitted.

[0141] The binder resin is not particularly limited as long as it can fix the allergen reducing agent to the fiber surface. For example, examples of binder resins include urethane resins such as one-component urethane resins and two-component urethane resins, silicone resins, acrylic resins, urethane acrylate resins, polyester resins, unsaturated polyester resins, alkyd resins, vinyl acetate resins, vinyl chloride resins, epoxy resins, and epoxy acrylate resins, with urethane resins and polyester resins being preferred. It is preferable that the binder resin does not have acidic functional groups or salts thereof in its molecule.

[0142] The method described in (1) above will be explained in detail. An allergen-reducing solution is prepared by dispersing an allergen-reducing agent in water. If the niobium compound contained in the allergen-reducing agent is niobium oxide, the surface of the niobium oxide reacts with water to produce niobium oxide having a layer of niobium hydroxide on its surface. Niobium hydroxide and niobium oxide having a layer of niobium hydroxide on its surface can be easily dispersed in water, and an allergen-reducing solution with excellent storage stability can be prepared.

[0143] The fibers are immersed in the allergen-reducing solution described above to impregnate them with the solution. Subsequently, the allergen-reducing solution is dried to evaporate and remove the water contained in it, causing the niobium compound to form a water-resistant film on the surface of the fibers. At this time, it is presumed that some of the hydroxyl groups of niobium hydroxide undergo dehydration condensation to form a cross-linked structure. This film adheres firmly to the fibers and has excellent water resistance, remaining stably on the fiber surface even after water treatment such as washing, and can provide an excellent allergen-reducing effect.

[0144] The content of niobium compounds in the allergen-reducing solution is preferably 0.01 parts by mass or more, more preferably 0.02 parts by mass or more, and more preferably 0.03 parts by mass or more, per 100 parts by mass of water. The content of niobium compounds in the allergen-reducing solution is preferably 10 parts by mass or less, more preferably 8 parts by mass or less, and more preferably 7 parts by mass or less, per 100 parts by mass of water. The content of niobium compounds in the allergen-reducing solution is preferably 0.01 to 10 parts by mass per 100 parts by mass of water. When the niobium compound is 0.01 parts by mass or more, an excellent allergen-reducing effect can be imparted to the fibers. When the niobium compound is 10 parts by mass or less, the niobium compound can be uniformly dispersed in the allergen-reducing solution, a uniform film formed from the niobium compound can be formed on the surface of the fibers, and an excellent allergen-reducing effect can be uniformly imparted to the fibers.

[0145] The amount of niobium compound to be contained in the fiber is preferably 0.01 parts by mass or more, more preferably 0.02 parts by mass or more, and even more preferably 0.03 parts by mass or more, per 100 parts by mass of fiber. The amount of niobium compound to be contained in the fiber is preferably 10 parts by mass or less, more preferably 8 parts by mass or less, and even more preferably 5 parts by mass or less, per 100 parts by mass of fiber. The amount of niobium compound to be contained in the fiber is preferably 0.01 to 10 parts by mass, per 100 parts by mass of fiber.

[0146] The amount of niobium compound to be included in the fabric is 0.01 g / m². 2 The above is preferable, and 0.02 g / m 2 The above is more preferable, 0.03 g / m 2 The above is more preferable. The amount of niobium compound to be contained in the fabric is 5 g / m 2 The following is preferable: 3 g / m 2 The following is more preferable: 1 g / m 2 The following is more preferable: The amount of niobium compound to be contained in the fabric is 0.01 to 5 g / m². 2 It is preferable.

[0147] [Allergen-reducing paint (coating film)] Allergen-reducing paint can be produced by incorporating an allergen-reducing agent into the paint. That is, the allergen-reducing paint comprises the paint and the niobium compound contained in the paint. The coating film produced from the allergen-reducing paint exhibits an excellent allergen-reducing effect.

[0148] Conventional known paints are used as coatings, including, for example, oil-based paints (e.g., mixed paints, oil varnishes, etc.), cellulose coatings, synthetic resin coatings, and water-based coatings. The coatings also include photocurable coatings that polymerize upon irradiation with radiation such as ultraviolet light to produce binder resin components. Water-based coatings contain the water-based solvent and binder resin described later.

[0149] The paint contains a binder resin, but this binder resin is not particularly limited as long as it can fix the allergen reducing agent to the substrate surface. Examples of binder resins include urethane resins such as one-component urethane resins and two-component urethane resins, silicone resins, acrylic resins, urethane acrylate resins, polyester resins, unsaturated polyester resins, alkyd resins, vinyl acetate resins, vinyl chloride resins, epoxy resins, and epoxy acrylate resins, with vinyl chloride resins being preferred.

[0150] Paints may contain additives such as pigments, plasticizers, hardeners, fillers, antioxidants, thickeners, and surfactants, to the extent that they do not impair the physical properties of the paint. Methods for producing allergen-reducing paints by incorporating allergen-reducing agents into the paint include, for example, supplying the allergen-reducing agent and the paint to a dispersion device and mixing them uniformly. Examples of dispersion devices include high-speed mills, ball mills, and sand mills.

[0151] The paint may contain a solvent to adjust its viscosity. The solvent may be either an aqueous solvent or an organic solvent. The organic solvent is not particularly limited and includes, for example, toluene, xylene, methyl ethyl ketone, acetone, ethyl acetate, and benzene. The aqueous solvent is not particularly limited and includes, for example, water and lower alcohols (alcohols with 4 or fewer carbon atoms, such as methanol, ethanol, propanol, and butanol), with a preferred aqueous medium containing 50% by mass or more of water. The organic solvent and aqueous solvent may be used individually or in combination of two or more.

[0152] The content of the allergen reducing agent in 100% by mass of the allergen-reducing paint is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and more preferably 1% by mass or more. The content of the allergen reducing agent in 100% by mass of the allergen-reducing paint is preferably 20% by mass or less, more preferably 15% by mass or less, and more preferably 10% by mass or less. The content of the allergen reducing agent in 100% by mass of the allergen-reducing paint is preferably 0.01 to 20% by mass.

[0153] The content of niobium compounds in 100% by mass of allergen-reducing paint is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and more preferably 1% by mass or more. The content of niobium compounds in 100% by mass of allergen-reducing paint is preferably 20% by mass or less, more preferably 15% by mass or less, and more preferably 10% by mass or less. The content of niobium compounds in 100% by mass of allergen-reducing paint is preferably 0.01 to 20% by mass.

[0154] Building interior materials are not particularly limited and can include, for example, flooring, wallpaper, ceiling materials, paint, doorknobs, switches, switch covers, and wax.

[0155] Vehicle interior accessories and vehicle interior materials are not particularly limited and may include, for example, seats, child seats, seat belts, car mats, seat covers, doors, ceiling materials, floor mats, door trims, instrument panels, consoles, glove boxes, straps, handrails, etc.

[0156] The present invention will be described more specifically below with reference to examples, but the present invention is not limited thereto. Specific numerical values ​​such as blending ratios (content), physical properties, and parameters used in the following description may be replaced with the corresponding upper limits (numerical values ​​defined as "less than or equal to" or "less than") or lower limits (numerical values ​​defined as "greater than or equal to") of the blending ratios (content), physical properties, and parameters described in the "Means for Solving the Problem" and "Modes for Carrying Out the Invention" sections.

[0157] The following niobium compounds, other compounds, acidic compounds, and inorganic oxides were prepared. The particle sizes of the niobium compounds and inorganic oxides are shown in Tables 1 and 4. In the tables, "Volume D50," "Volume D90," "Scattered Light D50," and "Scattered Light D90" refer to "D50 particle size based on volume," "D90 particle size based on volume," "D50 particle size based on scattered light intensity," and "D90 particle size based on scattered light intensity," respectively.

[0158] [Niobium Oxide] ・Niobium Oxide 1 (Allergen-reducing solution in which 6% by mass of niobium pentoxide (Nb2O5) particles are dispersed in a solvent (water), containing 0.5% by mass of citric acid and 0.3% by mass of ammonia as additives, turbidity: 39) ・Niobium Oxide 2 (Niobium pentoxide (Nb2O5), particulate) ・Niobium Oxide 3 (Niobium pentoxide (Nb2O5), particulate) ・Niobium Oxide 4 (Niobium pentoxide (Nb2O5), particulate) ・Niobium Oxide 5 (Allergen-reducing solution in which 6% by mass of niobium pentoxide (Nb2O5) particles are dispersed in a solvent (water), containing 0.5% by mass of citric acid and 0.3% by mass of ammonia as additives, turbidity: 125) - Niobium oxide 6 (an allergen-reducing solution in which 6% by mass of niobium pentoxide (Nb2O5) particles are dispersed in a solvent (water), containing 0.5% by mass of citric acid and 0.3% by mass of ammonia as additives, turbidity: 160) - Niobium oxide 7 (an allergen-reducing solution in which 6% by mass of niobium pentoxide (Nb2O5) particles are dispersed in a solvent (water), containing 0.5% by mass of citric acid and 0.3% by mass of ammonia as additives, turbidity: 340)

[0159] [Niobium hydroxide] ・Niobium hydroxide 1 (Nb(OH)5, particulate) ・Niobium hydroxide 2 (Nb(OH)5, particulate)

[0160] [Other compounds] ・Tin oxide (particulate)

[0161] [Acidic Compounds] • Sodium p-phenolsulfonate • Sodium m-phenolsulfonate • Potassium hydroquinonesulfonate • Disodium 4,5-dihydroxy-1,3-benzenedisulfonate • p-phenolsulfonic acid • Pentasodium ethylenediaminetetramethylenephosphonate • Sodium polyacrylate • Acidic compound 1 (manufactured by Konishi Chemical Industry Co., Ltd., trade name "WSR-SP82", aqueous solution with 32.3% by mass of the active ingredient, weight-average molecular weight: 10000, formula (6e), m and n are integers of 2 or more that represent the number of repeating units.)

[0162] [Inorganic Oxides] ・Aluminum oxide (Al2O3) (particulate) ・Silicon dioxide (silica) (particulate)

[0163]

[0164] (Examples 1-14, Comparative Example 1) Allergen reducing agents were prepared by uniformly mixing predetermined amounts (parts by mass) of niobium compounds, other compounds, and acidic compounds as shown in Table 1. In Table 1, the amount of "niobium compound" refers to the amount of "niobium pentoxide" or "niobium hydroxide" without the solvent.

[0165] The allergen reduction rate (allergen reduction effect) and dispersion stability of the obtained allergen reducing agent were measured according to the following procedure, and the results are shown in Tables 2 and 3.

[0166] [Coating film (water-based paint)] Freeze-dried powder of dust mite allergen (Derf1) (ITEA Co., Ltd. product name "Dust mite allergen extract, code 4-DF-001"), freeze-dried powder of dust mite allergen (Derf2) (ITEA Co., Ltd. product name "Dust mite allergen extract"), and freeze-dried powder of pollen allergen (Cryj1) (ITEA Co., Ltd. product name "Japanese cedar pollen extract, code 4-CJ-001").

[0167] A reagent for measuring the abundance of dust mite allergen (Derf1) (product name "Dust mite allergen (Derf1) ELISA kit, code 1-DF1-001" manufactured by ITEA Corporation) and a reagent for measuring the abundance of pollen allergen (Cryj1) (product name "Japanese cedar pollen allergen (Cryj1) ELISA kit, code 1-CJ-001" manufactured by ITEA Corporation) were prepared.

[0168] An allergen-reducing coating was prepared by adding a binder resin (Resonac Co., Ltd. product name "Polysol AM-200", solvent: water, solids content: 40% by mass) to 10 parts by mass of the obtained allergen-reducing agent as solids, so that the total solids content was 90 parts by mass. Next, a polyester film was prepared as a substrate. The allergen-reducing coating was applied to one side of this substrate so that the film thickness after drying was 18 μm, and then dried in an oven at 120°C for 1 hour to produce an allergen-reducing product with a coating film formed on one side.

[0169] The freeze-dried powder of the above allergen was dissolved in purified water to prepare an allergen aqueous solution containing 10 μg / mL of the allergen. Then, PBS-T (phosphate buffer containing 0.05% by mass of Tween 20 (manufactured by Tokyo Chemical Industry Co., Ltd.), pH: 7.4) was added to the allergen aqueous solution and mixed uniformly to prepare an allergen solution containing 15 ng / mL of the allergen.

[0170] The above allergen-reducing product was cut into a flat square with sides of 5 cm, 0.4 mL of the above allergen solution was dropped onto the coating film, and then the product was covered with a flat square polyethylene film with sides of 4 cm and left at 25°C for 24 hours to prepare the test solution. Next, the amount of allergen present in the test solution W1 (ng / mL) was measured using the above measurement reagent.

[0171] A blank product with a coating formed on one side was prepared in the same manner as above, except that a binder resin (Resonac Co., Ltd. product name "Polysol AM-200", solvent: water, solids content: 40% by mass) was used as the blank coating instead of the allergen-reducing coating. The amount of allergen W0 (ng / mL) present in the test solution was measured in the same manner as above, except that a blank product was used instead of the allergen-reducing product. The allergen reduction rate (%) was calculated based on the following formula: Allergen reduction rate (%) = 100 - (W1 / W0) × 100

[0172] [Fabric 1 (Initial)] The same materials used as those used in the above [Coating Film (Water-based Paint)] were used as dust mite allergen (Derf1), pollen allergen (Cryj1), and measurement reagents.

[0173] Purified water was added to 1 g of the obtained allergen reducing agent and mixed uniformly to prepare an allergen reducing solution containing 1% by mass of the allergen reducing agent as solid content.

[0174] Next, as the base material, we used polyester fabric (woven fabric, manufactured by Irozome Co., Ltd., product name "Polyester Tropical Toray", weight: 120 g / m²). 2 A polyester cloth was prepared. The polyester cloth was immersed in 100 g of the allergen-reducing solution for 2 minutes. The immersed polyester cloth was squeezed with a manual mangle and dried at 120°C for 10 minutes to produce an allergen-reducing cloth in which the allergen-reducing agent was fixed to the polyester fibers. In the allergen-reducing cloth, the allergen-reducing agent was 1 g / m 2 It was contained. A niobium compound coating was formed on the surface of the polyester fibers of the allergen-reducing fabric.

[0175] The freeze-dried powder of the above allergen was dissolved in purified water to prepare an allergen aqueous solution containing 10 μg / mL of the allergen. Then, PBS-T (phosphate buffer containing 0.05% by mass of Tween 20 (manufactured by Tokyo Chemical Industry Co., Ltd.), pH: 7.4) was added to the allergen aqueous solution and mixed uniformly to prepare an allergen solution containing 15 ng / mL of the allergen.

[0176] 0.4 g of allergen-reducing cloth was placed in a resealable plastic bag, 1 mL of the above allergen solution was added dropwise, the bag was sealed, and left at 25°C for 2 hours to prepare the test solution.

[0177] Next, the amount of allergen W1 (ng / mL) in the test solution was measured using the above-mentioned measurement reagent.

[0178] The amount of allergen W0 (ng / mL) present in the test solution was measured in the same manner as described above, except that the allergen-reducing cloth was not placed in a resealable plastic bag. The allergen reduction rate (%) was calculated based on the following formula: Allergen reduction rate (%) = 100 - (W1 / W0) × 100

[0179] [Fabric 1 (after washing)] An allergen-reducing fabric was prepared in the same manner as [Fabric 1 (initial)] above. The following washing test was performed on the obtained allergen-reducing fabric.

[0180] (Washing Test) ・Washing machine A fully automatic washing machine conforming to the Type C standard washing machine - vertical shaft, top-loading type (pulsator type) specified in JIS L 1930 was used. ・Detergent JAFET standard blend detergent (containing polyoxyethylene alkyl ether and alpha-olefin sulfonate sodium) was used. ・Loading cloth Type III polyester loading cloth specified in Annex H of JIS L 1930 was used. ・Washing machine force The conditions conformed to washing method C4G specified in Annex F of JIS L 1930. ・Washing method (1) Washing was performed under washing conditions with the above washing machine force adjusted. (2) JAFET standard blend detergent was added at a ratio of 40 mL to 30 L of water to make a washing solution, and after washing five times consecutively, the allergen-reducing cloth was dried at 80°C or below.

[0181] The allergen reduction rate of the allergen-reducing fabric after washing was measured in the same manner as for [Fabric 1 (initial)].

[0182] [In the dark] Using the allergen reducing agents of Examples 1 and 4, an allergen-reducing product was prepared in the same manner as described above for [Cloth 1 (initial)].

[0183] The allergen reduction rate of the obtained allergen-reducing product was measured in a dark place where no light was incident, using the same procedure as for [Fabric 1 (Initial)] above. The results are shown in Table 3.

[0184] [Dispersion Stability] 100 mL of the allergen-reducing solution prepared in the same manner as in [Cloth 1 (Initial)] above was taken into a vial, shaken well to mix uniformly, and then allowed to stand. The time until precipitation occurred was measured. A: No precipitation occurred even after more than 1 hour. B: Precipitation occurred within 1 hour. C: Precipitation occurred within 5 minutes.

[0185] (Examples 15-20) Allergen reducing agents were prepared by uniformly mixing predetermined amounts (parts by mass) of niobium compounds and inorganic oxides shown in Table 4. In Table 4, the amount of "niobium compound" refers to the amount of "niobium pentoxide" or "niobium hydroxide" without the solvent.

[0186] [Fabric 2 (Initial)] and [Fabric 2 (After Washing)] Purified water was added to 1 g of the obtained allergen reducing agent and mixed uniformly to prepare an allergen reducing solution containing 0.1% by mass of the allergen reducing agent as solid content. In Table 4, if "Binder resin present" was indicated, the solution was mixed to contain 0.1% by mass of the binder resin (water-soluble polyester resin, product name "Pluscoat Z-3310" manufactured by Go-O Chemical Co., Ltd.) as solid content. For all other cases, the allergen reduction rate was measured in the same manner as for [Fabric 1 (Initial)] and [Fabric 1 (After Washing)] above. The results are shown in Table 5.

[0187] [Dispersion Stability] Dispersion stability was evaluated in the same manner as described above, except that 1 g of the obtained allergen reducing agent was mixed uniformly with purified water to prepare an allergen reducing solution containing 1% by mass of the allergen reducing agent as solid content. The results are shown in Table 5.

[0188] [Fluorescent X-ray Measurement] An allergen-reducing cloth was prepared using the allergen-reducing agent of Example 15, in the same manner as the measurement of [Cloth 2 (Initial)]. In addition, a blank cloth was prepared in the same manner as in Example 15, except that the allergen-reducing agent of Example 15 did not contain a niobium compound.

[0189] Fluorescent X-ray measurements were performed on the allergen-reducing fabric and the blank fabric in the manner described above, and the results are shown in Figure 1 (allergen-reducing fabric of Example 15) and Figure 2 (blank fabric).

[0190]

[0191]

[0192]

[0193]

[0194]

[0195] (Cross-reference of related applications) This application claims priority under Japanese Patent Application No. 2024-189459 filed on 29 October 2024, Japanese Patent Application No. 2025-89114 filed on 28 May 2025, and Japanese Patent Application No. 2025-155598 filed on 19 September 2025, the disclosures of this application are incorporated herein by reference to the whole of these applications.

[0196] The allergen reducing agent of the present invention has an excellent allergen reducing effect, and it is possible to produce allergen-reducing products that exhibit an excellent allergen reducing effect.

Claims

1. An allergen reducing agent characterized by containing at least one niobium compound, which is niobium oxide or niobium hydroxide.

2. The allergen reducing agent according to claim 1, characterized in that the niobium compound is in particulate form.

3. The allergen reducing agent according to claim 2, characterized in that the volume-based D50 particle size of the niobium compound is 0.001 to 20 μm.

4. The allergen reducing agent according to any one of claims 1 to 3, characterized in that the niobium compound is niobium pentoxide.

5. The allergen reducing agent according to any one of claims 1 to 3, further comprising an acidic compound having an acidic functional group or a salt thereof in its molecule.

6. The allergen reducing agent according to claim 5, characterized in that the acidic functional group is a sulfo group.

7. An allergen reducing agent according to any one of claims 1 to 3, characterized in that it further contains an inorganic oxide other than niobium oxide.

8. An allergen-reducing liquid characterized by comprising a solvent and an allergen-reducing agent according to any one of claims 1 to 3, dispersed in the solvent.

9. The allergen-reducing liquid according to claim 8, characterized in that the solvent contains water.

10. The allergen-reducing liquid according to claim 9, further comprising an ammonium compound.

11. An allergen-reducing fiber characterized by comprising a fiber and at least one niobium compound, which is present on the surface of the fiber, consisting of niobium oxide and niobium hydroxide.

12. The allergen-reducing fiber according to claim 11, characterized in that the surface of the fiber has a coating of a niobium compound.

13. An allergen-reducing fabric characterized by containing the allergen-reducing fiber described in claim 11 or claim 12.

14. A method for producing allergen-reducing fibers, characterized by comprising the step of immersing fibers in the allergen-reducing liquid described in claim 8 to fix the allergen-reducing agent to the fibers.

15. A method for reducing allergens, characterized by contacting an allergen with at least one niobium compound, which is niobium oxide or niobium hydroxide, to reduce the allergen.

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