Cleansing composition

Abstract

A cleansing composition comprises 3 to 20% by weight of a surfactant composition, preferably 5 to 18% by weight, more preferably, 5 to 10% by weight, based on the overall cleansing composition, wherein the surfactant composition comprises: an anionic surfactant comprising a first anionic surfactant comprising: 11 to 30% by weight of C8 to C10 chains, preferably, 12 to 25% by weight C8 to C10 chains, more preferably, 13 to 20% by weight C8 to C10 chains, based on the total weight of the anionic surfactant; wherein a ratio of C8 to C10 chains is 4:1 to 1:1, preferably 3:1 to 1:1, most preferably 2:1 to 1:1 in the first anionic surfactant; wherein the anionic surfactant comprises 70 to 92% by weight C12 to C14 chains, based on the total weight of the anionic surfactant; and less than or equal to 0.5% by weight C16 to C18 chains, based on the total weight of the anionic surfactant; and a zwitterionic surfactant.

Description

[0001] P00001245 CPL

[0002] 1

[0003] CLEANSING COMPOSITION

[0004] Field of the Invention

[0005] Disclosed herein is a cleansing composition. The cleansing composition comprises an 5 anionic surfactant comprising a first anionic surfactant and a second anionic surfactant and a zwitterionic surfactant.

[0006] Background of the Invention

[0007] Personal cleansing processes characteristically involve the use of surfactant comprising compositions (i.e. wash compositions) and water to topically generate consumer-desired lather and to rinse off the compositions typically applied to the face, hands, hair, and / or body. Such activities are performed daily, often more than once a day, and especially, as it relates to the hands and face of a consumer. Ideally, washing can be optimized when using stable products that are mild, have excellent lather characteristics and that 15 rinse off with relative ease.

[0008] Personal cleansing formulations for skin and hair have historically been based on some combination of surfactants which include sodium lauryl ether sulfate (SLES). SLES offers the advantages of being widely available, an effective foaming agent, and 20 inexpensive. However, the universal dependence of the industry on SLES has also exposed a number of shortcomings.

[0009] Surfactants based on the sulfate headgroup are widely identified with washing off the skin and scalp’s protective barrier, leading to redness, dryness, and itch. Long term use 25 can lead to dermatitis and edema. Eye irritation is also an issue with SLES. For these reasons, SLES is judged to be harsh to skin and scalp and there is currently industrywide interest in so-called sulfate free cleansing surfactants, meaning that sulfonate- and carboxylate-based surfactants which are mild to skin and scalp are under development.

[0010] 30 The ether-component of SLES is also under scrutiny because products containing it can be contaminated with hundreds of ppm levels of 1,4-dioxane as a by-product of production. Recent regulations regarding 1,4-dioxane have made its removal from products which contact humans as being actively encouraged.P00001245 CPL

[0011] 2

[0012] For all these reasons, there is a need for an effective, foaming agent which does not rely on a head group containing sulfate. Surfactant headgroups based on sodium methyl taurate and sodium isethionate are good examples of sulfate and 1,4-dioxane free alternatives which still provide surface activity and good foaming. Popular commercial 5 examples of these surfactants include sodium methyl lauroyl taurate, sodium methyl cocoyl taurate, sodium lauroyl isethionate, and sodium cocoyl isethionate.

[0013] U.S. Patent No. 10,441,522 B2 to Schelges etal. discloses cleansing compositions that include at least one specific preservative combination. The cleansing compositions are used for cleansing and / or caring for the skin and / or hair, and the specific preservative combination is used for the preservation of surfactant-containing cleansing compositions.

[0014] It is continually desired to develop personal cleansing compositions and formulations 15 that are mild to the skin and have excellent in-use properties, such as foaming.

[0015] Summary of the Invention

[0016] Disclosed in various aspects are cleansing compositions.

[0017] 20 A cleansing composition comprises 3 to 20% by weight of a surfactant composition, preferably 5 to 18% by weight, more preferably, 5 to 15% by weight, based on the overall cleansing composition, wherein the surfactant composition comprises: an anionic surfactant comprising a first anionic surfactant comprising: 11 to 30% by weight of C8 to C10 chains, preferably, 12 to 25% by weight C8 to C10 chains, more preferably, 13 to 25 20% by weight C8 to C10 chains, based on the total weight of the anionic surfactant;

[0018] wherein a ratio of C8 to C10 chains in the first anionic surfactant is 4:1 to 1:1, preferably 3:1 to 1:1, most preferably 2:1 to 1:1; wherein the anionic surfactant comprises 70 to 92% by weight C12 to C14 chains, based on the total weight of the anionic surfactant; and less than or equal to 0.5% by weight C16 to C18 chains, based on the total weight 30 of the anionic surfactant; and a zwitterionic surfactant.

[0019] These and other features and characteristics are more particularly described below.P00001245 CPL

[0020] 3

[0021] Detailed Description of the Invention

[0022] Disclosed herein is a cleansing composition that comprises an anionic surfactant and a zwitterionic surfactant. It was surprisingly found that manipulation of alkyl chains of a first anionic surfactant, for example, a fatty acyl isethionate, allowed a greater than 20% 5 reduction in preservative level present in the cleansing composition while still achieving at least a 3-log reduction by day 7, preferably complete kill by day 7, against gram positive bacteria and gram-negative non-fermenting bacteria, more preferably, at least a 3-log reduction by day 7 and preferably complete kill by day 7 against gram positive bacteria, gram-negative non-fermenting bacteria, and gram-negative fermenting bacteria. Manipulation of the alkyl chains can include increasing the levels of C8 and C10 chains. It was unexpectedly found that when a ratio of C8 to C10 isethionate was greater than 1, then at least a 3-log reduction by day 7 against both gram positive bacteria and gram-negative non-fermenting bacteria was achieved. For example, the ratio of C8 to C10 chains can be 4: 1 to 1:1, preferably 3:1 to 1:1, most preferably 2: 1 to 15 1:1. In an embodiment, the ratio is 4:1 to 1:1, preferably 3:1 to 1:1, most preferably 2:1 to 1:1.

[0023] The cleansing compositions disclosed herein are mild and are substantially free or essentially free of sulfate. The cleansing compositions are also substantially free or 20 essentially free of 1,4-dioxane. In an embodiment, the cleansing compositions are sulfate free and 1,4-dioxane free.

[0024] Replacing part of the C12 groups in the anionic surfactant can reduce reliance on palm kernel oil. For example, replacing a portion of the C12 chains in the anionic surfactant 25 allows for a closer match to the natural distribution of chains in palm kernel oil, thereby allowing more efficient use of palm kernel oil.

[0025] Substantially free or essentially free as used herein refers to an amount of less than or equal to 100 parts per million in the cleansing composition, for example, less than 50 30 ppm in the cleansing composition, for example, less than or equal to 25 ppm in the cleansing composition, for example, less than or equal to 10 ppm in the cleansing composition, for example, less than or equal to 5 ppm in the cleansing composition, for example, less than or equal to 4 ppm in the cleansing composition, for example, less than or equal to 2 ppm in the cleansing composition, for example, less than or equal toP00001245 CPL

[0026] 4

[0027] 1 ppm in the cleansing composition, for example, less than or equal to 0.5 ppm in the cleansing composition.

[0028] The cleansing composition can comprise 3 to 20% by weight of a total amount of 5 surfactant, for example, 5 to 18% by weight of a total amount of surfactant, for example, 5 to 15% by weight of a total amount of surfactant, for example, 5 to 10% by weight of a total amount of surfactant, based on the total weight of the cleansing composition, including any and all ranges and values subsumed therein.

[0029] 10 The surfactant can comprise an anionic surfactant and a zwitterionic surfactant. A weight ratio of anionic surfactant to zwitterionic surfactant can be 1:4 to 1:1, for example, the weight ratio can be 1 :2 to 3:4. Total anionic surfactant may preferably be present in an amount of from 1 to 5 wt%, preferably from 2.5 to 5 wt%, based on the weight of the composition. The total amount of zwitterionic surfactant may preferably be from 2 to 15 15 wt%, preferably of from 4 to 8 wt%, based on the weight of the composition.

[0030] The anionic surfactant can comprise a first anionic surfactant and a second anionic surfactant. The first anionic surfactant can comprise 11 to 30% by weight C8 to C10 chains, preferably, 12 to 25% by weight C8 to C10 chains, more preferably, 13 to 20% 20 by weight C8 to C10 chains, based on the total weight of the anionic surfactant. The first anionic surfactant can comprise 70 to 92% by weight C12 to C14 chains, based on the total weight of the anionic surfactant and the first anionic surfactant can comprise less than or equal to 0.5% by weight C16 to C18 chains, based on the total weight of the anionic surfactant.

[0031] 25

[0032] A ratio of C8 to C10 chains can be greater than or equal to 1 in the first anionic surfactant. Such a ratio was observed to have at least a 3-log reduction by day 7 against both grampositive bacteria and gram-negative non-fermenting bacteria. For example, the ratio of C8 to C10 chains can be 4:1 to 1:1, preferably 3:1 to 1:1, most preferably 2:1 to 1:1. In 30 an embodiment, the ratio is 4:1 to 1:1, preferably 3:1 to 1:1, most preferably 2:1 to 1:1.

[0033] The C14 chains can be present in an amount of less than or equal to one half of the sum of C12 and C14 chains present in the first anionic surfactant, for example, the C14 chains can be present in an amount of less than or equal to one third of the sum of C12 and 35 C14 chains present in the first anionic surfactant.P00001245 CPL

[0034] 5

[0035] The first anionic surfactant can be present in an amount of greater than or equal to 80% by weight of the anionic surfactant, for example, 85% by weight of the anionic surfactant, for example, greater than or equal to 90% by weight of the anionic surfactant, for 5 example, greater than or equal to 95% by weight of the anionic surfactant, for example, greater than or equal to 97% by weight of the anionic surfactant, for example, greater than or equal to 99% by weight of the anionic surfactant, including any and all ranges and values subsumed therein.

[0036] 10 The second anionic surfactant can be present in an amount of less than or equal to 20% by weight of the anionic surfactant, for example, less than or equal to 15% by weight of the anionic surfactant, less than or equal 10% by weight of the anionic surfactant, for example, less than or equal to 5% by weight of the anionic surfactant, for example, less than or equal to 3% by weight of the anionic surfactant, for example, less than or equal 15 to 1 % by weight of the anionic surfactant.

[0037] In addition to the anionic surfactant and the zwitterionic surfactant, the cleansing composition can also comprise a nonionic surfactant, an amphoteric surfactant, a cationic surfactant, ora combination thereof. The cleansing composition can contain the 20 surfactant in a total amount of 3 to 20% by weight, preferably 5 to 18% by weight, more preferably 5 to 15% by weight, based on the total weight of the cleansing composition.

[0038] The first anionic surfactant can include aliphatic sulfonates, such as a primary alkane (e.g., C8-C22) sulfonate, primary alkane (e.g., C8-C22) disulfonate, C8-C22 alkene 25 sulfonate, C8-C22 hydroxyalkane sulfonate or alkyl glyceryl ether sulfonate (AGS); or aromatic sulfonates such as alkyl benzene sulfonate.

[0039] The anionic surfactant may also be alkyl sulfosuccinates (including mono- and dialkyl, e.g., C6-C22 sulfosuccinates); alkyl and acyl taurates (often methyl taurates), alkyl and 30 acyl sarcosinates, sulfoacetates, C8-C22 alkyl phosphates and phosphonates, alkyl phosphate esters and alkoxyl alkyl phosphate esters, acyl lactates, C8-C22 monoalkyl succinates and maleates, sulphoacetates, amino acid derived anionics such as glycinates, alanates, etc., acyl isethionates, and the like.

[0040] 35 Sulfosuccinates may be monoalkyl sulfosuccinates having the formula:P00001245 CPL

[0041] 6

[0042] R1OC(O)CH2CH(SO3M)CO2M;

[0043] and amide-MEA sulfosuccinates of the formula:

[0044] 5

[0045] R1CONHCH2CH2OC(O)CH2CH(SO3M)CO2M

[0046] wherein R1ranges from Cs-C22alkyl and M is a solubilizing cation such as sodium, potassium, ammonium or substituted ammonium.

[0047] Sarcosinates are generally indicated by the formula:

[0048] R2CON(CH3)CH2CO2M, wherein R2ranges from Cs-C2o alkyl.

[0049] 15 Taurates are generally identified by formula:

[0050] R3CONR4CH2CH2SO3M

[0051] wherein R3is a Cs-C2o alkyl, R4is a C1-C4 alkyl.

[0052] 20

[0053] M is a solubilizing cation as previously described.

[0054] The cleansing composition disclosed herein may contain Cs-Cis acyl isethionates. These esters are prepared by a reaction between alkali metal isethionate with mixed aliphatic 25 fatty acids having from 6 to 18 carbon atoms and an iodine value of less than 20. At least 75% of the mixed fatty acids have from 12 to 18 carbon atoms and up to 25% have from 6 to 10 carbon atoms.

[0055] The acyl isethionate may be an alkoxylated isethionate such as is described in llardi et al., U.S. Pat. No. 5,393,466, entitled “Fatty Acid Esters of Polyalkoxylated isethonicacid”; issued Feb. 28, 1995; hereby incorporated by reference. This compound has the general formula:

[0056] R5C— (0)0— C(X)H— C(Y)H— (OCH2— CH2)m— SO3MP00001245 CPL

[0057] 7

[0058] wherein R5is an alkyl group having 8 to 18 carbons, m is an integer from 1 to 4, X and Y are each independently hydrogen or an alkyl group having 1 to 4 carbons and M is a solubilizing cation as previously described.

[0059] 5 In an aspect of the cleansing composition, the first anionic surfactant comprises isethionate. In an aspect of the cleansing composition, the first anionic surfactant is isethionate. The first anionic surfactant can comprise sodium lauroyl isethionate. In an aspect, the first anionic surfactant is sodium lauroyl isethionate. The isethionate can be present in an amount of greater than or equal to 80% by weight of the anionic surfactant, for example, greater than or equal to 85% by weight of the anionic surfactant, for example, greater than or equal to 90% by weight of the anionic surfactant, for example, greater than or equal to 95% by weight of the anionic surfactant, for example, greater than or equal to 97% by weight of the anionic surfactant, for example, greater than or equal to 99% by weight of the anionic surfactant.

[0060] 15

[0061] As previously described, the anionic surfactant can optionally contain a second anionic surfactant. In an aspect the anionic surfactant contains a second anionic surfactant. The second anionic surfactant can be present in an amount of less than or equal to 20% by weight of the anionic surfactant, for example, less than or equal to 15% by weight of the 20 anionic surfactant, less than or equal 10% by weight of the anionic surfactant, for example, less than or equal to 5% by weight of the anionic surfactant, for example, less than or equal to 3% by weight of the anionic surfactant, for example, less than or equal to 1 % by weight of the anionic surfactant.

[0062] 25 The second anionic surfactant can comprise sodium lauroyl methyl taurate, sodium lauroyl taurate, sodium gluconate, sodium lauroyl glycinate, sodium lauroyl glutamate, sodium lauroyl methyl isethionate, sodium lauryl sarcosinate, alpha olefin sulfonate (AOS), or a combination thereof.

[0063] 30 Amphoteric surfactants can be included in the cleansing compositions disclosed herein.

[0064] Amphoteric surfactants (which depending on pH can be zwitterionic) include sodium acyl amphoacetates, sodium acyl amphopropionates, disodium acyl amphodiacetates and disodium acyl amphodipropionates, where the acyl (i.e. , alkanoyl group) can comprise a C7-C18 alkyl portion. Illustrative examples of amphoteric surfactants include sodiumP00001245 CPL

[0065] 8

[0066] lauroamphoacetate, sodium cocoamphoacetate, sodium lauroamphoacetate, or a combination thereof.

[0067] As to the zwitterionic surfactants employed in the present cleansing composition, such 5 surfactants include at least one acid group. Such an acid group may be a carboxylic or a sulphonic acid group. They often include quaternary nitrogen, and therefore, can be quaternary amino acids. They should generally include an alkyl or alkenyl group of 7 to 18 carbon atoms and generally comply with an overall structural formula:

[0068] R6— [— C(O)— NH(CH2)q— ],— N+(R7)(R8)-A— B

[0069] where R6is alkyl or alkenyl of 7 to 18 carbon atoms; R7and R8are each independently alkyl, hydroxyalkyl or carboxyalkyl of 1 to 3 carbon atoms; q is 2 to 4; r is 0 to 1; A is alkylene of 1 to 3 carbon atoms optionally substituted with hydroxyl, and B is — CO2 — or 15 — SO3— .

[0070] Desirable zwitterionic surfactants for use in the cleansing composition disclosed herein and within the above general formula include simple betaines of formula:

[0071] 20 R6— N+(R7)(R8)-CH2CO2‘

[0072] and amido betaines of formula:

[0073] R6— CONH(CH2)t— N+(R7)(R8)-CH2CO2- 25 where t is 2 or 3.

[0074] In both formulae R6, R7and R8are as defined previously. R6may, in particular, be a mixture of Ci2and C14 alkyl groups derived from coconut oil so that at least half, preferably at least three quarters of the groups R6have 10 to 14 carbon atoms. R7and 30 R8are preferably methyl.

[0075] A further possibility is that the zwitterionic surfactant is a sulphobetaine of formula:P00001245 CPL

[0076] 9

[0077] R6— N+(R7)(R8)-(CH2)3SO3- or

[0078] R6— CONH(CH2)U— N+(R7)(R8)-(CH2)3SO3- 5

[0079] where u is 2 or 3, or variants of these in which — (CH2)3SO3‘ is replaced by

[0080] — CH2C(OH)(H)CH2SO3-.

[0081] In these formulae, R6, R7and R8are as previously defined.

[0082] Illustrative examples of the zwitterionic surfactants desirable for use include betaines such as lauryl betaine, betaine citrate, cocodimethyl carboxymethyl betaine, cocoamidopropyl betaine, coco alkyldimethyl betaine, and laurylamidopropyl betaine.

[0083] 15 An additional zwitterionic surfactant suitable for use includes cocoamidopropyl sultaine, for example, cocamidopropyl hydroxysultaine. Other desirable zwitterionic surfactants include sodium hydroxymethylglycinate, coco alkyldimethyl betaine, oleyl betaine, cocoamidopropyl betaine, (carboxymethyl) dimethyloleylammonium hydroxide, cocoamidopropyl betaine, stearyl betaine, cocamidopropyl hydroxysultaine, or a 20 combination thereof.

[0084] In an embodiment, the zwitterionic surfactant can comprise lauryl betaine, cocobetaine, lauramidopropyl betaine, coco alkyldimethyl betaine, oleyl betaine, cocoamidopropyl betaine, stearyl betaine, cocamidopropyl hydroxysultaine, lauryl hydroxysultaine, or a 25 combination thereof.

[0085] In an embodiment, the zwitterionic surfactant is lauryl betaine, cocobetaine, lauramidopropyl betaine, coco alkyldimethyl betaine, oleyl betaine, cocoamidopropyl betaine, stearyl betaine, cocamidopropyl hydroxysultaine, lauryl hydroxysultaine, or a 30 combination thereof. Such surfactants are made commercially available from suppliers like Stepan Company, Solvay, Evonik and the like and it is within the scope of the cleansing compositions disclosed herein to employ mixtures of the aforementioned surfactants.P00001245 CPL

[0086] 10

[0087] Nonionic surfactants may optionally be used in the cleansing composition. When used, nonionic surfactants are typically used at levels as low as 0.5, 1, 1.5 or 2% by weight and at levels as high as 6, 8, 10 or 12% by weight. The nonionic surfactants which can be used include in particular the reaction products of compounds having a hydrophobic 5 group and a reactive hydrogen atom, for example aliphatic alcohols, acids, amides or alkylphenols with alkylene oxides, especially ethylene oxide either alone or with propylene oxide. Specific nonionic surfactant compounds are alkyl (C6-C22) phenols, ethylene oxide condensates, the condensation products of aliphatic (Cs-Cis) primary or secondary linear or branched alcohols with ethylene oxide, and products made by condensation of ethylene oxide with the reaction products of propylene oxide and ethylenediamine. Other nonionic surfactants include long chain tertiary amine oxides, long chain tertiary phosphine oxides, dialkyl sulphoxides, and the like.

[0088] In an aspect, nonionic surfactants can include fatty acid / alcohol ethoxylates having the 15 following structures a) CH3(CH2)s(CH2CH2O)v H or b) CH3(CH2)c(COO)(CH2CH2O)dH;

[0089] where s and v are each independently an integer up to 18; and c and d are each independently an integer from 1 or greater. In an aspect, s and v can be each independently 6 to 18; and c and d can be each independently 1 to 30. Other options for nonionic surfactants include those having the formula CH3(CH2)i — CH=CH — 20 (CH2)k(CH2CH2O)z H, where i, k are each independently 5 to 15; and z is 5 to 50. In another aspect, i and k are each independently 6 to 12; and z is 15 to 35.

[0090] The nonionic surfactant may also include a sugar amide, such as a polysaccharide amide. Specifically, the surfactant may be one of the lactobionamides described in U.S.

[0091] 25 Pat. No. 5,389,279 to Au et al., entitled “Compositions Comprising Nonionic Glycolipid Surfactants” issued Feb. 14, 1995; which is hereby incorporated by reference or it may be one of the sugar amides described in U.S. Pat. No. 5,009,814 to Kelkenberg, titled “Use of N-Poly Hydroxyalkyl Fatty Acid Amides as Thickening Agents for Liquid Aqueous Surfactant Systems” issued Apr. 23, 1991; hereby incorporated into the subject 30 application by reference.

[0092] Illustrative examples of nonionic surfactants that can be used in the cleansing compositions disclosed herein include, but are not limited to, polyglycoside, cetyl alcohol, decyl glucoside, lauryl glucoside, octaethylene glycol monododecyl ether, n-octyl beta-P00001245 CPL

[0093] 11

[0094] d-thioglucopyranoside, octyl glucoside, oleyl alcohol, ethoxylated sorbitan esters, sorbitan esters, ethoxylated fatty alcohols, stearyl alcohol, or a combination thereof.

[0095] In an aspect, cationic surfactants can be used in the cleansing composition of the present 5 application.

[0096] One class of cationic surfactants includes heterocyclic ammonium salts such as cetyl or stearyl pyridinium chloride, alkyl amidoethyl pyrrylinodium methyl sulfate, and lapyrium chloride.

[0097] 10

[0098] Tetra alkyl ammonium salts are another useful class of cationic surfactants for use. Examples include cetyl or stearyl trimethyl ammonium chloride or bromide; hydrogenated palm or tallow trimethylammonium halides; behenyl trimethyl ammonium halides or methyl sulfates; decyl isononyl dimethyl ammonium halides; ditallow (or 15 distearyl) dimethyl ammonium halides, and behenyl dimethyl ammonium chloride.

[0099] Still other types of cationic surfactants that may be used are the various ethoxylated quaternary amines and ester quats. Examples include PEG-5 stearyl ammonium lactate (e.g., Genamin KSL manufactured by Clariant), PEG-2 coco ammonium chloride, PEG- 20 15 hydrogenated tallow ammonium chloride, PEG 15 stearyl ammonium chloride, dipalmitoyl ethyl methyl ammonium chloride, dipalmitoyl hydroxyethyl methyl sulfate, and stearyl amidopropyl dimethylamine lactate.

[0100] Still other useful cationic surfactants include quaternized hydrolysates of silk, wheat, and 25 keratin proteins, and it is within the scope of the cleansing composition to use mixtures of the aforementioned cationic surfactants.

[0101] If used, cationic surfactants will make up no more than 1.0% by weight of the cleansing composition. When present, cationic surfactants typically make up from 0.01 to 0.7%, 30 and more typically, from 0.1 to 0.5% by weight of the cleansing composition, including any and all ranges and values subsumed therein.

[0102] The cleansing composition can additionally include up to 60% by weight skin benefit agents. The term “skin benefit agent” is defined as a substance which softens or 35 improves the elasticity, appearance, and youthfulness of the skin (stratum corneum) byP00001245 CPL

[0103] 12

[0104] either increasing its water content, adding, or replacing lipids and other skin nutrients, or both, and keeps it soft by retarding the decrease of its water content. Included among the desirable skin benefit agents are emollients, including, for example, hydrophobic emollients, hydrophilic emollients, or blends thereof. Preferred benefit agents include 5 moisturizers, emollients, sunscreens, and anti-aging compounds.

[0105] Desirably the optional skin benefit agents used in the cleansing composition disclosed herein include niacinamide (vitamin B3), tocopherol (Vitamin E), aloe vera, alpha-hydroxy acids and esters, beta-hydroxy acids and esters, glycerol, hydroxyethyl urea, 10 polyhydroxy acids and esters, creatine, hydroquinone, t-butyl hydroquinone, mulberry, hyaluronic acid and salts thereof (including, but not limited to, Na+and K+salts of the same), extract, liquorice extract, resorcinol derivatives, or a combination thereof. For example, the skin benefit agent can be sodium hyaluronate. Such benefit agents, including sodium hyaluronate can be present in an amount of 0.0001 to 10%, for 15 example, 0.001 to 6.5%, for example, 0.01 to 3.5%, and for example, 0.01% by weight, based on total weight of the cleansing composition, including any and all ranges and values subsumed therein.

[0106] Further optional water-soluble skin benefit agents include acids, such as amino acids 20 like arginine, valine or histidine. Other vitamins can be used such as vitamin B2, picolinamide, panthenol (vitamin B5), vitamin Be, vitamin C, a combination thereof or the like. Derivatives (generally meaning something that has developed or been obtained from something else), and especially, water soluble derivatives of such vitamins can also be employed. For instance, vitamin C derivatives such as ascorbyl tetraisopalmitate, 25 magnesium ascorbyl phosphate and ascorbyl glycoside may be used alone or in combination with each other. Niacinamide derivatives such as nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH) may be used alone or in combination with each other. Other skin benefit agents that can be used include 4-ethyl resorcinol, glycerol, extracts like sage, aloe vera, green tea, sugar 30 cane, citrus, grapeseed, thyme, chamomile, yarrow, cucumber, liquorice, rosemary extract, or a combination thereof. The total amount of optional water-soluble benefit agents (including mixtures) when present in the composition disclosed herein can be 0.0001 to 10%, preferably, 0.001 to 6.5%, and most preferably, 0.01 to 3.5% by weight, based on total weight of the cleansing composition, including any and all values and 35 ranges subsumed therein.P00001245 CPL

[0107] 13

[0108] It is also within the scope of the cleansing composition to optionally include oil soluble benefit agents. Illustrative examples of the types of oil soluble benefit agents that can optionally be used in the cleansing composition disclosed herein include components 5 like stearic acid, vitamins like vitamin A, D, E and K (and their oil soluble derivatives).

[0109] Other optional oil soluble benefit agents for use include resorcinols and resorcinol derivatives like 4-hexyl resorcinol, 4-phenylethyl resorcinol, 4-cyclopentyl resorcinol, 4- cyclohexyl resorcinol 4-isopropyl resorcinol or a combination thereof. Also, 5-substituted 10 resorcinols like 4-cyclohexyl-5-methylbenzene-1,3-diol, 4-isopropyl-5-methylbenzene- 1 ,3-diol, combination thereof or the like may be used. The 5-substituted resorcinols and their synthesis are described in commonly assigned U.S. Published Patent Application No. 2016 / 0000669A1, which is incorporated by reference herein in its entirety.

[0110] 15 Even other oil soluble benefit agents that can be used include omega-3 fatty acids, omega-6 fatty acids, climbazole, magnolol, honokiol, farnesol, ursolic acid, myristic acid, geranyl geraniol, oleyl betaine, cocoyl hydroxyethyl imidazoline, hexanoyl sphingosine, 10- hydroxy stearic acid (10HSA), 12-hydroxystearic acid (12HSA), petroselinic acid, conjugated linoleic acid, stearic acid, palmitic acid, lauric acid, terpineol, thymol essential 20 components, the dissolution auxiliary selected from limonene, pinene, camphene, cymene, citronellol, citronellal, geraniol, nerol, linalool, rhodinol, borneol, isoborneol, menthone, camphor, safrole, isosafrole, eugenol, isoeugenol, tea tree oil, eucalyptus oil, peppermint oil, neem oil, lemon grass oil, orange oil, bergamot oil, moringa oil or a combination thereof. In this respect it is noted that the amount of C6-C14 fatty acid 25 preferably is below 3 wt%, more preferably below 1 wt%, even more preferably below 0.1 wt% and most preferably C6-C14 fatty acid is absent. It is preferred, that the level of lauric acid is below 3 wt%, more preferably below 1 wt%, even more preferably below 0.1 wt% and most preferably lauric acid is absent. Low or even absence of these fatty acids reduces opacity. The present invention prefers to provide a clear composition. 30

[0111] Another optional oil soluble benefit agent that may be used is a retinoic acid precursor. The retinoic acid precursor can be retinol, retinal, retinyl ester, retinyl propionate, retinyl palmitate, retinyl acetate or a combination thereof. Retinyl propionate, retinyl palmitate, and combinations thereof are typically preferred. Still another retinoic acid precursor for 35 use is hydroxyanasatil retinoate made commercially available under the nameP00001245 CPL

[0112] 14

[0113] RETEXTRA® as supplied by Molecular Design International. The same may be used in a combination with any of the oil soluble benefit agents described herein.

[0114] When an optional (i.e., 0.0 to 1.5% by weight) oil soluble benefit agent is used in the 5 cleansing composition, it typically is present in an amount of 0.001 to 1.5% by weight of the overall cleansing composition including any and all values and ranges subsumed therein, and for example, 0.05 to 1.2% by weight, for example, 0.2 to 0.5% by weight of the total weight of the cleansing composition.

[0115] Other useful skin benefit agents include the following:

[0116] (a) silicone oils and modifications thereof such as linear and cyclic polydimethylsiloxanes; amino, alkyl, alkylaryl, and aryl silicone oils;

[0117] (b) fats and oils including natural fats and oils such as jojoba, soybean, sunflower, rice bran, avocado, almond, olive, sesame, persic, castor, coconut, and mink oils; 15 cacao fat; beef tallow and lard; hardened oils obtained by hydrogenating the aforementioned oils; and synthetic mono, di and triglycerides such as myristic acid glyceride and 2-ethylhexanoic acid glyceride;

[0118] (c) waxes such as carnauba, spermaceti, beeswax, lanolin, and derivatives thereof; (d) hydrophobic and hydrophilic plant extracts;

[0119] 20 (e) hydrocarbons such as liquid paraffin, petrolatum, microcrystalline wax, ceresin, squalene, pristan and mineral oil;

[0120] (f) higher fatty acids such as lauric, myristic, palmitic, stearic, behenic, oleic, linoleic, linolenic, lanolic, isostearic, arachidonic and poly unsaturated fatty acids (PLIFA); (g) higher alcohols such as lauryl, cetyl, stearyl, oleyl, behenyl, cholesterol and 2- 25 hexydecanol alcohol;

[0121] (h) esters such as cetyl octanoate, myristyl lactate, cetyl lactate, isopropyl myristate, myristyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholesterol isostearate, glycerol monostearate, glycerol monolaurate, glycerol distearate, glycerol tristearate, alkyl lactate, alkyl citrate and alkyl tartrate; 30 (i) essential oils and extracts thereof such as mentha, jasmine, camphor, white cedar, moringa, bitter orange peel, ryu, turpentine, cinnamon, bergamot, citrus unshiu, calamus, pine, lavender, bay, clove, hiba, eucalyptus, lemon, starflower, thyme, peppermint, rose, sage, sesame, ginger, basil, juniper, lemon grass, rosemary,P00001245 CPL

[0122] 15

[0123] rosewood, avocado, grape, grapeseed, myrrh, cucumber, watercress, calendula, elder flower, geranium, linden blossom, amaranth, seaweed, ginko, ginseng, carrot, guarana, tea tree, jojoba, comfrey, oatmeal, cocoa, neroli, vanilla, green tea, penny royal, aloe vera, menthol, cineole, eugenol, citral, Citronelle, borneol, 5 linalool, geraniol, evening primrose, camphor, thymol, spirantol, penene, limonene and terpenoid oils;

[0124] (j) polyhydric alcohols, for example, glycerine, sorbitol, propylene glycol, and the like;

[0125] and polyols such as the polyethylene glycols, examples of which are: POLYOX™ WSR-205 PEG 14M, POLYOX™ WSR-N-60K PEG 45M, or POLYOX™ WSR-N- 750, and PEG 7M;

[0126] (k) lipids such as cholesterol, ceramides, sucrose esters and pseudo-ceramides as described in European Patent Specification No. 556,957;

[0127] (l) vitamins, minerals, and skin nutrients such as milk, vitamins A, E, and K; vitamin alkyl esters, including vitamin C alkyl esters; magnesium, calcium, copper, zinc 15 and other metallic components;

[0128] (m) sunscreens such as octyl methoxyl cinnamate (Parsol MCX) and butyl methoxy benzoylmethane (Parsol 1789);

[0129] (n) phospholipids; and

[0130] (o) anti-aging compounds such as alpha-hydroxy acids and beta-hydroxy acids. 20

[0131] Preferred skin benefit agents include fatty acids, hydrocarbons, polyhydric alcohols, polyols, and mixtures thereof, with emollients that include at least one C12 to C18 fatty acid, petrolatum, glycerol, glycerin, sorbitol, and / or propylene glycol being of particular interest in one or more embodiments. The agents may be added at an appropriate step 25 during the process of making the cleansing compositions. Some benefit agents may be introduced as macro domains.

[0132] The cleansing composition can further comprise a humectant. The humectant can be present in an amount of 0.1 to 15% by weight, preferably 0.5 to 10% by weight, more 30 preferably 0.75 to 8% by total weight of the cleansing composition, including any and all ranges and values subsumed therein. The humectant can be employed to assist in moisturization effects of the cleansing composition. Humectants are generally known as moisturizers that attract water from the air or deeper in the skin. Stated another way,P00001245 CPL

[0133] 16

[0134] humectants draw water into the skin, hair, or nails. The humectants can generally be polyhydric alcohol type materials. Typical polyhydric alcohols include glycerol (i.e., glycerine or glycerin), propylene glycol, dipropylene glycol, polypropylene glycol (e.g., PPG-9), polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3- 5 butylene glycol, isoprene glycol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol, or a combination thereof. Most preferred is glycerin, propylene glycol, dipropylene glycol, or a combination thereof. In an embodiment, the humectant can be propylene glycol, butylene glycol, dipropylene glycol, glycerin, triethylene glycol, erythritol, capryl glycol, hyaluronic acid, polypropylene glycol-7 proypyl heptyl ether, or a 10 combination thereof.

[0135] Other optional ingredients like antioxidants, fragrances, perfumes, polymers, chelating agents, colorants, deodorants, dyes, enzymes, foam boosters, germicides, antimicrobials, lathering agents, pearlescers, skin conditioners, stabilizers, or superfatting 15 agents, may be added in suitable amounts in the process of making the cleansing compositions.

[0136] Additional optional ingredients which may be present in the cleansing compositions are, for example: fragrances; sequestering and chelating agents such as tetrasodium 20 ethylenediaminetetraacetate (EDTA), ethane hydroxyl diphosphonate (EHDP), and etidronic acid, aka 1-hydroxyethylidene diphosphonic acid (HEDP); coloring agents; opacifiers, and pearlizers such as zinc stearate, magnesium stearate, titanium dioxide (TiC>2), ethylene glycol monostearate (EGMS), ethylene glycol distearate (EGDS) or Lytron 621 (Styrene / Acrylate copolymer), and the like; pH adjusters; antioxidants, for 25 example, butylated hydroxytoluene (BHT) and the like; stabilizers; suds boosters, such as for example, coconut acyl mono- or diethanol amides; ionizing salts, such as, for example, sodium chloride and sodium sulfate, and other ingredients such as are conventionally used in cleansing compositions. The total amount of such additional optional ingredients is typically from 0 to 10% by weight, more particularly from 0.1 to 5% 30 by weight, based on the total weight of the cleansing composition, including any and all ranges and values subsumed therein.

[0137] The cleansing compositions disclosed herein can be used to deliver antimicrobial benefits. Antimicrobial agents that can be included to deliver these benefits include 35 oligodynamic metals or compounds thereof. Preferred metals are silver, copper, zinc,P00001245 CPL

[0138] 17

[0139] gold, aluminum, or a combination thereof. Silver is particularly preferred. In the ionic form it may exist as a salt or any compound in any applicable oxidation state. Preferred silver compounds are silver oxide, silver nitrate, silver acetate, silver sulfate, silver benzoate, silver salicylate, silver carbonate, silver citrate, silver phosphate, or a 5 combination thereof, with silver oxide, silver sulfate and silver citrate being of particular interest in one or more embodiments. In at least one aspect, the silver compound is silver oxide. Oligodynamic metal or a compound thereof can be included in an amount of 0.0001 to 2%, preferably 0.001 to 1% by weight of the cleansing composition. Alternately an essential oil antimicrobial active may be included in the cleansing 10 composition. Essential oil actives which can be included are terpineol, thymol, carvacol, (E) -2(prop-1-enyl) phenol, 2- propylphenol, 4- pentylphenol, 4-sec-butylphenol, 2-benzyl phenol, eugenol, or a combination thereof. Furthermore, preferred essential oil actives are terpineol, thymol, carvacrol, thymol, or a combination thereof, with the most preferred being terpineol or thymol, or a combination thereof. When present, essential oil actives 15 can be included in an amount of 0.001 to 1%, preferably 0.01 to 0.5% by weight of the composition.

[0140] Even other ingredients which may be used include octopirox (piroctone), zinc pyrithione, chloroxylenol, triclosan, cetylpyridinium chloride, citrate esters such as triethyl citrate, as 20 well as silver compounds including silver oxide, nitrate, sulfate, phosphate, carbonate, acetate, benzoate, a combination thereof or the like. If used, these other components typically make up from 0.001 to 1.6% by weight of the overall cleansing composition including any and all values and ranges subsumed therein, and preferably, from 0.01 to 1.2% by weight of the overall cleansing composition including any and all values and 25 ranges subsumed therein.

[0141] The cleansing composition can further comprise a preservative. Illustrative preservatives for use include sodium benzoate, iodopropynyl butyl carbamate (IPBC), caprylyl glycol (1,2-octane diol), phenoxyethanol, hydroxyacetophenone, 30 ethylhexylglycerine, methyl paraben, propyl paraben, imidazolidinyl urea, sodium dehydroacetate, propanediol, dimethyl-dimethyl (DMDM) hydantoin, alkyl esters of parahydroxybenzoic acid, organic acids and salts thereof, hydroxyacetophenone, climbazole, propionate salts, a variety of quaternary ammonium compounds, benzyl alcohol, or a combination thereof. Other preservatives suitable for use include sodium 35 dehydroacetate, chlorophenesin, and decylene glycol. Preservatives can be employedP00001245 CPL

[0142] 18

[0143] in amounts of 0.01% to 2.0% by weight of the total weight of cleansing composition, including any and all values and ranges and values subsumed therein, for example, 0.05 to 1.5% by weight, for example, 0.1 to 0.75% by weight, for example, 0.3 to 0.75% by weight, based on the total weight of the cleansing composition.

[0144] 5

[0145] In an embodiment, a weight ratio of total surfactant composition to preservative in the cleansing composition can be 6 to 23, for example, 14 to 22. In an embodiment, the weight ratio of total surfactant composition to preservative in the cleansing composition is 6 to 23, preferably 14 to 22.

[0146] 10

[0147] Fragrances, fixatives, opacifiers (like titanium dioxide or glycol distearate), and chelating agents may optionally be included in the cleansing composition. Possible chelating agents include, but are not limited to, ethylyene diaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), ethylene diamine disuccinic acid (EDDS), 15 pentasodium diethylenetriaminepentaacetate, trisodium N-(hydroxyethyl)- ethylenediaminetracetate, an acid form of EDTA, sodium thiocynate, trisodium salt of methylglycinediacetic acid, tetrasodium glutamate diacetate and phytic acid, preferably wherein the chelating agent is ethylene diaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), ethylene diamine disuccinic acid (EDDS), or 20 a combination thereof. Each of these substances may be present in an amount of about 0.03 to about 3% by weight of the overall cleansing composition including all values and ranges subsumed therein, preferably, about 0.1 to about 2.6% by weight, weight of the overall cleansing composition including all values and ranges subsumed therein.

[0148] 25 The cleansing compositions can additionally comprise a viscosity adjusting agent. The viscosity adjusting agent can be a salt. The salt can comprise sodium chloride, potassium chloride, or a combination thereof. In an embodiment, the viscosity adjusting agent is a salt and the salt is sodium chloride, potassium chloride, or a combination thereof. The salt can be present in an amount of less than or equal to 2% of the overall 30 cleansing composition.

[0149] Polymeric viscosity adjusting agents are an optional but often desired ingredient in the cleansing composition. Preferred polymers are those generally classified as high molecular weight ethoxylated fatty acid esters. Illustrative examples include PEG 120 35 methyl glucose dioleate, PEG 18 glyceryloleate / cocoate, PEG 150 pentaerythritolP00001245 CPL

[0150] 19

[0151] tetrastearate, or combinations thereof, or the like. One polymeric viscosity aid is PEG 150 pentaerythritol tetrastearate which is sold under the VERSATHIX™ name by Croda. When used, such aids make up from 0.001 to 0.8%, and preferably, from 0.001 to 0.5%, and most preferably, from 0.001 to 0.3% by weight of the cleansing composition, 5 including any and all ranges and values subsumed therein.

[0152] The cleansing composition disclosed herein can further include a thickening agent. Particularly preferred thickening agents include an anionic polymer-based thickener, preferably, for example, a polyacrylate based polymer or copolymer, or a combination 10 thereof. Polysaccharides can be used. Examples include fibers, starches, natural / synthetic gums and cellulosics. Representative of the starches are chemically modified starches such as sodium hydroxypropyl starch phosphate and aluminum starch octenylsuccinate. Tapioca starch is often preferred, as is maltodextrin. Suitable gums include xanthan, sclerotium, pectin, karaya, arabic, agar, guar (including Acacia Senegal 15 guar), carrageenan, alginate and combinations thereof. Suitable cellulosics include hydroxypropyl cellulose, hydroxypropyl methylcellulose, ethylcellulose, sodium carboxy methylcellulose (cellulose gum / carboxymethyl cellulose) and cellulose (e.g., cellulose microfibrils, cellulose nanocrystals or microcrystalline cellulose).

[0153] 20 Sources of cellulose microfibrils include secondary cell wall materials (e.g. wood pulp, cotton), bacterial cellulose, and primary cell wall materials. Preferably the source of primary cell wall material is selected from parenchymal tissue from fruits, roots, bulbs, tubers, seeds, leaves and combination thereof; more preferably is selected from citrus fruit, tomato fruit, peach fruit, pumpkin fruit, kiwi fruit, apple fruit, mango fruit, sugar beet, 25 beet root, turnip, parsnip, maize, oat, wheat, peas and combinations thereof; and even more preferably is selected from citrus fruit, tomato fruit and combinations thereof. A most preferred source of primary cell wall material is parenchymal tissue from citrus fruit. Citrus fibers, such as those made available by Herbacel® as AQ Plus can also be used as source for cellulose microfibrils. The cellulose sources can be surface modified by 30 any of the known methods including those described in Colloidal Polymer Science, Kalia et al., “Nanofibrillated cellulose: surface modification and potential applications” (2014), Vol 292, Pages 5-31.

[0154] As mentioned, synthetic polymers are effective thickening agents. This category includes 35 crosslinked polyacrylates such as the Carbomers, polyacrylamides such as SEPIGELP00001245 CPL

[0155] 20

[0156] 305™ and taurate copolymers such as SIMULGEL® EG and ARISTOFLEX® AVC, the copolymers being identified by respective INCI nomenclature as sodium acrylate / sodium acryloyldimethyl taurate and acryloyl dimethyltaurate / vinyl pyrrolidone copolymer. Another preferred synthetic polymer suitable for thickening is an acrylate-based polymer 5 made commercially available by Seppic and sold under the name SIMULGEL® INS100.

[0157] Calcium carbonate, fumed silica, and magnesium-aluminum-silicate may also be used.

[0158] Sodium hydroxypropyl starch phosphate, aluminum starch octenylsuccinate, tapioca starch, maltodextrin, xanthan gum, agar gum, guar gum, carrageenan gum, alginate gum, hydroxypropyl cellulose, hydroxypropyl methylcellulose, ethylcellulose, sodium carboxy methylcellulose, cellulose, polyethylene glycol (e.g., polyethylene glycol diester stearic acid), or a combination thereof are further examples of thickening agents for use in the present cleansing compositions. Such thickening agents are commercially available from the Dow Chemical Company or the Hallstar Company.

[0159] 15

[0160] Other optional ingredients include water soluble / dispersible polymers. These polymers can be cationic, anionic, amphoteric or nonionic types with molecular weights higher than 100,000 Dalton. They are known to increase the viscosity and stability of liquid personal cleansing formulation, to enhance in-use and after-use skin sensory properties, and to 20 enhance lather creaminess and lather stability. When present, the total amount of such polymers commonly ranges from 0.1 to 10% by weight of the personal cleansing formulation.

[0161] Examples of water soluble or dispersible polymers include the carbohydrate gums such 25 as cellulose gum, microcrystalline cellulose, cellulose gel, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium carboxymethylcellulose, methyl cellulose, ethyl cellulose, guar gum, gum karaya, gum tragacanth, gum arabic, gum acacia, gum agar, xanthan gum and mixtures thereof; modified and nonmodified starch granules and pregelatinized cold water soluble starch; emulsion polymers such as ACULYN® 28, 30 ACULYN® 22 or CARBOPOL® Aqua SF1; cationic polymer such as modified polysaccharides including cationic guar available from Rhone Poulenc under the trade name JAGUAR™ C13S, JAGUAR™ C14S, JAGUAR™ C17, or JAGUAR™ C16; cationic modified cellulose commercially available by Dow® such as UCARE™ Polymer JR-125, UCARE Polymer JR-400, UCARE Polymer KF, UCARE Polymer JR-30M,P00001245 CPL

[0162] 21

[0163] LICARE Polymer LR-400, LICARE Polymer LR-30M, LICARE Polymer LK mixtures thereof or the like.

[0164] Other preferred cationic polymers include those known as hydrophobically-modified 5 cationic conditioning polymers such as those made commercially available also by Dow® under the names SoftCATTM SL 5, SoftCAT SL 30, SoftCAT SL 60, SoftCAT SL 100, SoftCAT SK-L, SoftCAT SK-M, and SoftCAT SK-H; N-Hance® 3000, N-Hance® 3196, N- Hance® GPX 215 or N-Hance® GPX 196 from Hercules; synthetic cationic polymer such as Merquat® 100, Merquat® 280, Merquat®281 and Merquat®550 sold by Nalco; cationic starches such as StaLok® 100, 200, 300 and 400 sold by Staley Inc.; cationic galactomannans such as Galactasol® 800 series by Henkel, Inc.; Quadrosoft® LM-200; and Polyquaternium-24. Also suitable are high molecular weight polyethylene glycols such as Polyox® WSR-205 (PEG 14M), Polyox® WSR-N-60K (PEG 45), and Polyox® WSR-301 (PEG 90M).

[0165] 15

[0166] The cleansing compositions herein described can be produced by preparative techniques. In one very general methodology, to a heated aqueous phase of water, is added synthetic detergents and co-solvents in addition to, if present, any free fatty acids and caustic (to neutralize the fatty acid and form soap); the remaining ingredients are 20 added, as appropriate, as the product is cooled to room temperature.

[0167] The cleansing compositions can be provided in a variety of different product forms including, for example, hand, face and body washes, shower gels, bars, and the like, e.g., antimicrobial product forms including, for example, hand, face and body washes, 25 shower gels, bars, and the like. The formulations may be provided in bottles, pump dispensers, tubes, sachets, or other packaging suitable for the product form.

[0168] In use, the cleansing compositions are diluted, as needed, to form aqueous cleansing compositions that are applied to the skin for contact times less than 1 minute, more 30 particularly 30 seconds or less (with contact times of 10 to 30 seconds being of interest with respect to contact times of a moderate to a relatively long duration and contact times of 10 seconds or less being of interest with respect to contact times of short to moderate duration) and thereafter are removed from the skin, typically by rinsing with water. The cleansing compositions can be diluted before, after or simultaneous with its being placedP00001245 CPL

[0169] 22

[0170] on the skin, with dilution typically occuring by the formulation being worked into a lather in the hands or on an applicator, such as a facecloth, sponge or pouf.

[0171] Inorganic salt is an optional but often desired ingredient to aid in composition thickening.

[0172] 5 Salts that may be used include NaCI, KCI, MgCh, CaCh, combinations thereof, or the like. Typically, the inorganic salt makes up 0 to 10% by weight, and preferably, 0.001 to 12% by weight, more preferably, from 0.05 to 4.5% by weight, and even more preferably, 0.09 to 2% by weight of the concentrated cleansing composition, including any and all ranges and values subsumed therein.

[0173] Adjusters to modify / buffer the pH may be used. Such pH adjusters include triethylamine, NaOH, KOH, H2SO4, HCI, CeHsO? (i.e., citric acid), C3H6O3 (i.e., lactic acid), or a combination thereof. The pH adjusters are added at amounts to yield the desired final pH. The pH adjusters can include various alpha-hydroxy acids or a combination thereof.

[0174] 15 For example, the pH adjusters can comprise the alpha-hydroxy acids of citric acid, glycolic acid, lactic acid, malic acid, tartaric acid, or a combination thereof. The pH values can be assessed with commercial instrumentation such as a pH meter made commercially available from Thermo Scientific®. The pH adjusters can be present in an amount of 0.1 to 1.0% by weight of the cleansing composition, including any and all 20 ranges and values subsumed therein, for example, 0.1 to 0.75% by weight of the cleansing composition, including any and all ranges and values subsumed therein.

[0175] The pH of the composition is assessed by using conventional instrumentation such as a pH meter made commercially available from Thermo Scientific®. A pH of the cleansing 25 composition can be 3 to 9, preferably, 4 to 8, more preferably, 5 to 7.

[0176] The cleansing compositions disclosed herein typically contain water in an amount of 20 to 95% by weight, more particularly 50 to 93% by weight, more specially, 60 to 90% by weight, based on the total weight of the cleansing composition, including any and all 30 ranges and values subsumed therein. Such water contents are representative of a relatively broad range of formulations, including both concentrated and non-concentrates products, with formulations having water contents of 20 to less than 50% by weight of water being typical of concentrated products.P00001245 CPL

[0177] 23

[0178] Viscosity, unless noted otherwise, was measured with a Discovery HR-2 Rheometer using sand blasted plates with a 1000 micron gap at 25°C and a shear rate of 4 s’1.

[0179] The cleansing composition is essentially sulfate free. Preferably, the cleansing 5 composition is sulfate free.

[0180] The cleansing composition is essentially 1,4-dioxane free. Preferably, the cleansing composition is 1,4-dioxane free.

[0181] It was unexpectedly found that the cleansing composition disclosed herein had a greater than or equal to 3-log reduction by day 7 against gram positive and gram-negative nonfermenting bacteria. It was further unexpectedly found that the cleansing composition disclosed herein had a greater than or equal to 3-log reduction by day 7 against gram positive, gram-negative non-fermenting bacteria, and gram-negative fermenting 15 bacteria. In an embodiment, the cleansing composition disclosed herein had complete kill by day 7 against gram positive and gram-negative non-fermenting bacteria. In an embodiment, the cleansing composition disclosed herein had complete kill by day 7 against gram positive, gram-negative non-fermenting, and gram-negative fermenting bacteria. To determine this, products were inoculated with a respective organism or 20 organism mix as identified below at 1% of the formula weight. Challenged formulations were thoroughly mixed and stored near 25°C. At 7 days the challenged formulations were sampled for viable microorganisms. These samples were plated in a petri dish and incubated under conventional conditions appropriate for such test organisms and as identified in the American Type Culture Collection (ATCC) with the middle point of ranges 25 selected when criteria was defined by range. After incubation, the number of microbial colonies was counted and the resulting figure was multiplied by the appropriate dilution factor to obtain the number of microorganisms per sample unit. Preservation criteria are complete kill = pass, B criteria = greater than or equal to 3 log reduction. Fail < 3 log reduction. Strains of the following bacteria were used) Gram+ = S. aureus, gram30 fermenting = P. aeruginosa + B. cepacia, Gram - non-fermenting = P. gergoviae + K.

[0182] pneumoniae.

[0183] Except where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and / or useP00001245 CPL

[0184] 24

[0185] are to be understood as modified by the word “about.” All amounts are by weight of the final composition, unless otherwise specified.

[0186] It should be noted that in specifying any range of concentration or amount, any particular 5 upper concentration can be associated with any particular lower concentration or amount as well as any subranges consumed therein. In that regard, it is noted that all ranges disclosed herein are inclusive of the endpoints, and the endpoints are independently combinable with each other (e.g., ranges of up to 25% by weight, or, more specifically, 5% by weight to 20% by weight, in inclusive of the endpoints and all intermediate values 10 of the ranges of 5% by weight to 25% by weight, etc.). “Combination” is inclusive of blends, mixtures, alloys, reaction products, and the like. Furthermore, the terms “first”, “second”, and the like herein do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. The terms “a” and “an” and “the” herein do not denote a limitation of quantity and are to be construed to cover both the 15 singular and the plural, unless otherwise indicated herein or clearly contradicted by context. The suffix “(s)” as used herein is intended to include both the singular and the plural of the term it modifies, thereby including one or more of the terms (e.g., the film(s) includes one or more films). Reference throughout the specification to “one embodiment”, “one aspect”, “another embodiment”, “another aspect”, “an embodiment”, 20 “an aspect” and so forth means that a particular element (e.g., feature, structure, and / or characteristic) described in connection with the embodiment or aspect is included in at least one embodiment or aspect described herein and may or may not be present in other embodiments or aspects. In addition, it is to be understood that the described elements may be combined in any suitable manner in the various embodiments or 25 aspects.

[0187] All cited patents, patent applications, and other references are incorporated herein by reference in their entirety. However, if a term in the present application contradicts or conflicts with a term in the incorporated reference, the term from the present application 30 takes precedence over the conflicting term from the incorporated reference. While particular aspects have been described, alternatives, modifications, variations, improvements, and substantial equivalents that are or may be presently unforeseen may arise to applicants or others skilled in the art. Accordingly, the appended claims as filed and as they may be amended are intended to embrace all such alternatives, 35 modifications, variations, improvements, and substantial equivalents.P00001245 CPL

[0188] 25

[0189] For the avoidance of doubt the word “comprising” is intended to mean “including” but not necessarily “consisting of” or “composed of.” In other words, the listed steps, options, or alternatives need not be exhaustive.

[0190] 5

[0191] The disclosure of the invention as found herein is to be considered to cover all aspects as found in the claims as being multiply dependent upon each other irrespective of the fact that claims may be found without multiple dependency or redundancy. Unless otherwise specified, numerical ranges expressed in the format "from x to y" are 10 understood to include x and y. In specifying any range of values or amounts, any particular upper value or amount can be associated with any particular lower value or amount. All percentages and ratios contained herein are calculated by weight unless otherwise indicated. The various features of the present invention referred to in individual sections above apply, as appropriate, to other sections mutatis mutandis.

[0192] 15 Consequently, features specified in one section may be combined with features specified in other sections as appropriate. Any section headings are added for convenience only and are not intended to limit the disclosure in any way.

[0193] Examples

[0194] 20 The following examples are merely illustrative of the cleansing composition disclosed herein and are not intended to limit the scope hereof.

[0195] Tables 1 to 3 list compositions and results from the cleansing compositions tested.

[0196] 25 The samples were inoculated with a respective organism or organism mix as identified below at 1 % of the formula weight. Challenged formulations were thoroughly mixed and stored near 25°C. At 7 days the challenged formulations were sampled for viable microorganisms. These samples were plated in a petri dish and incubated under conventional conditions appropriate for such test organisms and as identified in the 30 American Type Culture Collection (ATCC) with the middle point of ranges selected when criteria was defined by range. After incubation, the number of microbial colonies was counted and the resulting figure was multiplied by the appropriate dilution factor to obtain the number of microorganisms per sample unit. Preservation criteria are complete kill = pass, B criteria = greater than or equal to 3 log reduction. Failure was demonstrated 35 with a less than 3 (< 3) log reduction. Strains of the following bacteria were used) Gram+P00001245 CPL

[0197] 26

[0198] = S. aureus, gram- fermenting = P. aeruginosa + B. cepacia, Gram - non-fermenting = P. gergoviae + K. pneumoniae.

[0199] Table 1: Cleansing Compositions

[0200]

[0201] 5 *CAPB=cocoamidopropyl betaine

[0202] Table 2: Cleansing Compositions

[0203]

[0204] P00001245 CPL

[0205] Table 3: Cleansing Compositions

[0206]

[0207] It was surprisingly found that manipulation of alkyl chains of the primary anionic 5 surfactant, a fatty acyl isethionate, allowed the preservative level to be reduced by greater than or equal to 20% and at least a 3 log reduction by day 7 was achieved with preferably complete kill by day 7 against gram positive and gram-negative nonfermenting bacteria and more preferably against gram positive, gram-negative nonfermenting, and gram-negative fermenting bacteria.

[0208] 10

[0209] The Control illustrated complete kill with a typical preservative level of 0.9% by weight. Comparative Examples 1, 3, 4, and 5 illustrated that at least a 3-log reduction by day 7 could not be achieved against both gram positive and gram-negative non-fermenting bacteria if the preservative level was decreased greater than 20%. Example 2 illustrated that by increasing the levels of short C8 and C10 chains by 1.8 times relative to the Control and Comparative Example 1 allowed a drop in preservative level by greater than 20% while still achieving at least a 3 log reduction by day 7 and preferably complete kill by day 7 against gram positive and gram-negative non-fermenting bacteria and more preferably against gram positive, gram-negative non-fermenting, and gram-negative 20 fermenting bacteria.P00001245 CPL

[0210] 28

[0211] Furthermore, it was unexpectedly found that the ratio of C8 to C10 isethionate must be greater than 1 for at least a 3-log reduction by day 7 against both gram positive and gram-negative non-fermenting bacteria (see Examples 2 and 3 versus Comparative Example 2).

[0212] 5

Claims

P00001245 CPL29Claims1. A cleansing composition, comprising:3 to 20% by weight of a surfactant composition, preferably 5 to 18% by weight, more preferably, 5 to 10% by weight, based on the overall cleansing composition, wherein the surfactant composition comprises:- an anionic surfactant comprising a first anionic surfactant comprising:o 11 to 30% by weight of C8 to C10 chains, preferably, 12 to 25% by weight C8 to C10 chains, more preferably, 13 to 20% by weight C8 to C10 chains, based on the total weight of the anionic surfactant;o wherein a ratio of C8 to C10 chains is 4:1 to 1:1, preferably 3:1 to 1:1, most preferably 2:1 to 1:1 in the first anionic surfactant;o wherein the anionic surfactant comprises 70 to 92% by weight C12 to C14 chains, based on the total weight of the anionic surfactant; and o less than or equal to 0.5% by weight C16 to C18 chains, based on the total weight of the anionic surfactant; and- a zwitterionic surfactant; and0.1 to 0.75% by weight of a preservative, based on the total weight of the cleansing composition, wherein a ratio of total surfactant composition to preservative in the cleansing composition is 14 to 22.

2. The cleansing composition of any Claim 1 , wherein a ratio of anionic surfactant to zwitterionic surfactant is 1:4 to 1:1, preferably, 1:2 to 3:4.

3. The cleansing composition of Claim 1 or Claim 2, wherein the first anionic surfactant comprises isethionate.

4. The cleansing composition of any of the preceding claims, wherein the first anionic surfactant comprises sodium lauryl isethionate.

5. The cleansing composition of any of the preceding claims, wherein the first anionic surfactant is present is an amount of greater than or equal to 80% by weight of total anionic surfactant present in the cleansing composition.P00001245 CPL306. The cleansing composition of any of the preceding claims, wherein the zwitterionic surfactant comprises lauryl betaine, cocobetaine, coco alkyldimethyl betaine, oleyl betaine, cocoamidopropyl betaine, stearyl betaine, cocamidopropyl hydroxysultaine, laurylamidopropyl betaine, lauryl hydroxysultaine, or a combination thereof.

7. The cleansing composition of any of the preceding claims, wherein the anionic surfactant further comprises a second anionic surfactant, wherein the second anionic surfactant is present in an amount of less than or equal to 20% by weight of the anionic surfactant.

8. The cleansing composition of any of the preceding claims, wherein the cleansing composition is essentially sulfate free, preferably wherein the cleansing composition is sulfate free.

9. The cleansing composition of any of the preceding claims, wherein the cleansing composition is essentially 1,4-dioxane free, preferably wherein the cleansing composition is 1,4-dioxane free.

10. The cleansing composition of any of the preceding claims, wherein the cleansing composition has a greater than or equal to 3 log reduction by day 7 against gram positive and gram-negative non-fermenting bacteria.

11. The cleansing composition of any of Claims 1 to 9, wherein the cleansing composition has a greater than or equal to 3 log reduction by day 7 against gram positive, gram negative non-fermenting, and gram negative fermenting bacteria.

12. The cleansing composition of any of Claims 1 to 9, wherein the cleansing composition has complete kill by day 7 against gram positive and gram-negative non-fermenting bacteria.

13. The cleansing composition of any of Claims 1 to 9, wherein the cleansing composition has complete kill by day 7 against gram positive, gram negative nonfermenting, and gram negative fermenting bacteria.

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