The invention relates to the system management field and provides a system and a method for preventing error locking and misoperation. The system comprises an equipment management system which is used for generating a work order and generating identifier containing appointed work information on the work order. For a corresponding access control system in a closed region, a first identifier scanning device is used for scanning the identifiers on the work order so as to obtain the appointed work information, and checking whether the work content of the closed region is matched with the appointed work information or not, if so, an unlocking instruction is sent to an electronic lock of the access control system, otherwise, no generation of the unlocking instruction is prompted. For field equipment, a second identifier scanning device is used for scanning the identifiers containing the appointed work information and field equipment identifiers, and checking whether the information in the identifiers of the field equipment is matched with the appointed work information, if so, the instruction of operation of the field equipment is prompted, otherwise, alarm is implemented. According to the system, safe and practical error locking prevention and anti-misoperation management can be realized.