105results about How to "Enhance stability" patented technology

A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced stability.

A suture cutter having a handle and a barrel with a movable cutting head on the barrel, and the barrel supporting a stationary cutting edge and a movable cutting edge. A movable support carries the movable cutting edge and includes a surface spaced from the stationary cutting edge a selected distance. An abutment wall spaced from the stationary cutting edge at the selected distance provides for snugly restricting movement of the moving cutting edge away from cutting contact with the stationary cutting edge while cutting the suture. Recesses are defined on a guiding support surface along which the movable cutting edge slides when the handle is actuated, allowing for sharpening of the moveable cutting edge when said edge is retracted proximally.

High affinity, chemically modified triplex-forming oligonucleotides (TFOs) and methods for use thereof are disclosed. TFOs are defined as triplex-forming oligonucleotides which bind as third strands to duplex DNA in a sequence specific manner. Triplex-forming oligonucleotides may be comprised of any possible combination of nucleotides and modified nucleotides. Modified nucleotides may contain chemical modifications of the heterocyclic base, sugar moiety or phosphate moiety. A high affinity oligonucleotide (Kd≦2×10−8) which forms a triple strand with a specific DNA segment of a target gene DNA is generated. It is preferable that the Kd for the high affinity oligonucleotide is below 2×10−10. The nucleotide binds or hybridizes to a target sequence within a target gene or target region of a chromosome, forming a triplex region. The binding of the oligonucleotide to the target region stimulates mutations within or adjacent to the target region using cellular DNA synthesis, recombination, and repair mechanisms. The mutation generated activates, inactivates, or alters the activity and function of the target gene.

A gait generating system of a legged mobile robot is provided with a device for determining a desired trajectory of an external force to be applied to a robot 1, a device for determining a parameter of a desired gait (current time gait) for a predetermined period on the basis of a desired trajectory of an external force or the like, a device for determining a parameter of a virtual cyclic gait that follows the current time gait on the basis of the desired trajectory of the external force or the like, a device for correcting the current time gait parameter such that a body motion trajectory of the robot 1 of the current time gait converges to a body motion trajectory of the cyclic gait, and a device for sequentially determining an instantaneous value of the current time gait on the basis of the corrected current time gait parameter. With this arrangement, in an environment wherein an external force acts on a robot as necessary, a desired gait that allows continual stability of the robot to be secured can be generated even if the external force suddenly changes.

The present invention relates to a composite hydrogel comprising a blend of an aqueous solution of an anionic polysaccharide or a derivative thereof, such as hyaluronan (also commonly referred to as hyaluronic acid) or a derivative thereof and an aqueous solution of methylcellulose or another water soluble cellulose derivative thereof, having dispersed polymeric particles, such as polymeric hydrophobic particles therein selected from micro particles and nanoparticles, and wherein the stability of the hydrogel is enhanced relative to the stability of the hydrogel alone. The polymeric particles may contain at least one therapeutic agent, in which case each therapeutic agent exhibits a linear sustained release rate that can be tuned or altered by selecting the appropriate polymer formulation of the micro particles and / or nanoparticles. The composite may be injectable, and in the absence of a therapeutic agent may be used as a bulking agent for reconstructive and cosmetic surgery or may act as a platform for subsequent delivery of therapeutic agents.

Compounds of the invention are novel peptide analogues of oxyntomodulin (oxm) in which one or more amino acids of the oxm sequence have been changed. Changing amino acids 15-24 of oxm to either amino acids 968-977 of the α-latrotoxin peptide (and variations thereof) or amino acids 15-24 of exendin-4 (and variations thereof), or combinations of sequences from these sources, and / or changing amino acids 27-33 of oxm to amino acids 27-33 of exendin-4, and / or the addition of amino acids to the C-terminus of the peptide, results in a series of analogues of oxm that demonstrate the oxm like activity of reducing food intake, and with certain embodiments a greater ability to decrease food intake.

An LED fluorescent tube structure includes a transparent cover, a cooling block, at least one LED lamp panel and a pair of side covers. The transparent cover includes a heat dissipating opening having a pair of first hooks, and an embedding slot. The top of the cooling block is provided for carrying the LED lamp panel and embedded into the transparent cover. A latch groove at the bottom of the cooling block has a tapered opening for latching the transparent cover. The side covers are sealed onto both end portions of the transparent cover respectively. The latch groove is designed with an angle for enhancing a latching effect to assure the spatial distance of the heat dissipating opening. The latch groove at a position connecting the cooling block is thickened to enhance the strength of the cooling block, prevent deformations, and improve the aesthetic look and using effect.

To control a wheel load of a wheel according to a lateral acceleration of a vehicle so as to enhance stability of the vehicle, provided is a suspension control apparatus, which is configured to control a wheel-load adjusting mechanism in at least one of the following manners: the wheel load of a front wheel is increased or is made unlikely to be reduced relative to the wheel load of a rear wheel when an absolute value of the lateral acceleration of the vehicle is increasing; and the wheel load of the rear wheel is increased or is made unlikely to be reduced relative to the wheel load of the front wheel when the absolute value of the lateral acceleration of the vehicle is reducing.

The present invention provides a combustor of a gas turbine engine, including: a fuel spray portion configured to spray a fuel so as to create a diffusion combustion region in a combustion chamber; a pre-mixture supply portion configured to supply a pre-mixture gas including the fuel and an air so as to create a pre-mixture combustion region in the combustion chamber, the pre-mixture supply portion being positioned concentrically with the fuel spray portion so as to surround the fuel spray portion; and an annular separation portion disposed between a downstream end of the fuel spray portion and a downstream end of the pre-mixture supply portion so as to separate the diffusion combustion region and the pre-mixture combustion region from each other.

A gas burner apparatus for discharging a mixture of fuel gas, air and flue gas into a furnace space of a furnace wherein the mixture is burned and flue gas having a low content of nitrous oxides and carbon monoxide is formed is provided. The burner tile includes at least one gas circulation port extending though the wall of the tile. The interior surface of the wall of the tile includes a Coanda surface. Fuel gas and / or flue gas conducted through the gas circulation port follows the path of the Coanda surface which allows more flue gas to be introduced into the stream. The exterior surface of the wall of the tile also includes a Coanda surface for facilitating the creation of a staged combustion zone. Also provided are improved burner tiles, improved gas tips and methods of burning a mixture of air, fuel gas and flue gas in a furnace space.

A boot swap method for multiple processor computer systems utilizes a baseboard management controller (BMC) to manage the abnormal booting problem of multiple processor computer systems. According to the usage state of the central processing unit (CPU) or the basic input / output system (BIOS) stored in read only memory (ROM), a CPU switching procedure or an ROM switching procedure is executed to select an available CPU and BIOS for booting. The method can greatly increase the system stability.

According to the switching supply such as a DC / DC converter, since primary side coils provided in two transformers are mutually connected in series, voltage variation generated in parallel-connected secondary side coils can be suppressed, and the uniformity of secondary side parallel output can be enhanced even in case of voltage value fluctuations or the like caused by variation in the output of an inverter circuit.

The external stabilizing structure is a structural element for use in work boots and similar types of footwear. The external stabilizing structure comprises a molded footbed of firm yet flexible material that provides external support under both the heel and arch of the wearer's foot.

A lyophilized polynucleotide composition contains at least one polynucleotide and at least one cryoprotectant, wherein the ratio of the polynucleotide to cryoprotectant is from about 0.001 to about 1.0 part by weight polynucleotide per 1.0 part by weight of the cryoprotectant. This composition also contains from about 0.5 weight percent to about (6) weight percent water, based on the total weight of the final lyophilized polynucleotide composition. The polynucleotide composition of this invention is characterized by enhanced stability, in that it retains at least 90% supercoil over a time period of at least (10) days at a temperature of about 37° C. The lyophilized polynucleotide composition also has improved solubility. An improved process for lyophilization of polynucleotides employs a specific primary drying cycle, that results in the above-described stable, lyophilized polynucleotide composition.

The invention provides compounds, compositions, methods, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step methods using luminogenic molecules, e.g. luciferins or coelenterazines, that are cytochrome P450 substrates and that are also bioluminescent enzyme, e.g., luciferase, pro-substrates are provided. The present method further provides a method for stabilizing and prolonging the luminescent signal in a luciferase-based assay using luciferase stabilizing agents such as reversible luciferase inhibitors.

Silylethynyl pentacenes and compositions containing silylethynyl pentacenes are disclosed. Exemplary pentacene compounds have 6,13-silylethynyl substitution with one or more groups (e.g., R, R′ and R″) covalently bonded to each Si atom of the silylethynyl groups. Methods of making and using silylethynyl pentacenes and compositions containing silylethynyl pentacenes are also disclosed. Substrates and devices comprising the silylethynyl pentacenes and compositions are also disclosed.

Disclosed is technology regarding a system and a method for power conversion, particularly technology for converting power, which is supplied from a plurality of power supply sources, using a plurality of power conversion modules. A plurality of power conversion modules, which can process all of various types of supplied power, are used to convert power according to the type of supplied power. An intermediate connection unit, which can selectively connect the power supply sources and the power conversion modules, is used so that, when one of the power conversion modules has a problem, another power conversion module is used instead to guarantee stable power supply. This construction makes the power processing path flexible and enhances system stability because, even if one of the power conversion modules malfunctions, power conversion can continue through another path.

The various embodiments of the present disclosure relate generally to thermally crosslinked polymeric compositions and methods of making thermally crosslinked polymeric compositions. An embodiment of the present invention comprises a composition comprising: a first polymer comprising a first repeat unit, the first repeat unit comprising a carboxyl group, wherein the first polymer crosslinks to a second polymer formed from a second repeat unit, and wherein the first polymer crosslinks to the second polymer without formation of an ester group.

Phase-locked loop structures are provided that facilitate enhanced stability of loop-generated signals. They include an oscillator network, a feedback loop and a controller. The oscillator network generates a loop output signal with a frequency that varies in response to a control voltage and to a frequency-determining parameter, the feedback loop generates the control voltage in response to the loop output signal and a reference signal and the controller increments the frequency-determining parameter to maintain the control voltage within a predetermined control-voltage range. These structures enhance signal stability by facilitating the use of low-gain oscillator structures and they simplify and shorten loop operations because the structures operate in a closed-loop condition at all times.

A combustion apparatus according to the present invention can positively control and generate burnt gas recirculation with a simple structure. The combustion apparatus has an annular container (12) having an inner cylindrical portion (15) forming an inner circumferential side surface, an outer cylindrical portion (13) forming an outer circumferential side surface, an open end (26), and a close end (10). A flow (28) of air is formed so as to have a velocity component in the direction of a central axis (J) from the open end (26) to the close end (10) and a velocity component to swirl in a circumferential direction of the annular container (12). Fuel (23) is injected so as to have a velocity component in the direction of the central axis (J) from the close end (10) to the open end (26) and a velocity component directed radially outward.

A clutch transmission mechanism of a printing device includes a power input shaft, a power input gear, a gear-shifting arm, a first gear-shifting module and a second gear-shifting module. In the cooperation of these components and modules, the printing device can be operated in a first gear-shifting mode or a second first gear-shifting mode. When the printing device can be operated in a first gear-shifting mode or a second first gear-shifting mode, the clutch transmission mechanism coaxially transmits the driving force. As such, the stability of transmitting the driving force is enhanced.

A faucet having a support bracket contains: a body, a flexible outlet pipe, a spray head, and a support bracket The body includes a vertical axis extending along a central portion thereof, and the flexible outlet pipe extends outwardly from a top of the body and includes an outflow segment. The spray head is connected with the outflow segment, the support bracket includes a first rotatable connector disposed on the body and includes a first tab extending outwardly from the first rotatable connector, wherein the first tab has a first rotation axis separated a distance from and perpendicular to the vertical axis. The support bracket includes a second rotatable connector having a head segments and a distal segment, wherein the head segment is rotatably connected with the first tab to form a first movable joint, and the distal segment is connected with or removed from the spray head.

This invention relates in general to micron or sub-micron particles comprising one or more water-soluble crystals wherein the crystals have a surface coating comprising one or more bioactive molecules as well as efficient methods of forming such particles and rapid methods for screening preferred conditions to form such particles. The particles are suitable for pharmaceutical formulations.

The present invention is directed to pharmaceutical compositions comprising bendamustine and one or more amphiphilic cationic compounds, which self assemble to form aggregates. The exhibiting enhanced stability in aqueous solutions, including plasma. The unexpectedly enhanced stability afforded by such aggregates permits patients to be treated with bendamustine in lower and / or with less frequent dosages or to improve its therapeutic effect while using the same as presently used treatment protocol.

An output buffer circuit capable of enhancing stability includes an operational amplifier, a capacitive load and an output control unit. The operational amplifier has a positive input terminal, a negative input terminal and an output terminal, and generates an output voltage to the output terminal according to an input voltage received by the positive input terminal. The output control unit is coupled between the output terminal of the operational amplifier and the capacitive load, and is utilized for controlling electrical connection between the output terminal of the operational amplifier and the capacitive load to forma signal output path and for adjusting impedance of the signal output path when the signal output path is formed.

A telescopic support having an outer support tube and an inner support that move with respect to each other along a longitudinal axis of the telescopic support. At least three bearing sets having roller bearings are affixed to one of the outer support tube or the inner support. The roller bearings of a bearing set may be spaced apart along the longitudinal axis, and may be configured such that a rotational axis of each of the roller bearings is substantially directed toward the longitudinal axis of the telescopic support.

A pixel structure includes a substrate, an opposite substrate, a scan line and a data line, an active device, a pixel electrode, and a passivation layer. The pixel electrode has at least one block-shaped electrode and a plurality of first branch electrodes. The passivation layer has at least one block-shaped protrusion pattern, a plurality of branch protrusion patterns, and a plurality of grooves. The first branch electrodes are located on the block-shaped protrusion patterns. An Edge of the block-shaped electrodes further extends to the block-shaped protrusion patterns. An orthogonal projection gap W1 is between an orthogonal projection edge of the block-shaped electrode and an orthogonal projection edge of the nearest first branch electrode, and 0 μm<W1≦5 μm. An orthogonal projection distance W2 is between the orthogonal projection edge of the block-shaped electrode and an orthogonal projection edge of the block-shaped protrusion pattern, and 0 μm<W2≦10 μm.

Permanent magnet bearings are incorporated into rotating equipment, such as induction machines, in addition to active magnetic or lubricated primary shaft support bearings. The passive magnetic bearings incorporate permanent magnets that generate directionally oriented magnetic fields of selective intensity. The magnetic field directions are aligned with a desired shaft support bearing preload direction and intensity, for example to exert axial thrust or radial preloads on the support bearings. A plurality of magnetic bearings may be oriented in opposed relationship with neutral or offsetting resultant forces. The passive magnetic force preload may be utilized to offset rotor vertical weight during induction startup or stopping cycles. Passive magnetic force preload may be applied to lubricated bearings to assure their operational stability. The passive magnetic bearings can also absorb radial or axial thrust forces imparted on the rotor shaft during induction machine operation, that may reduce machine operational noise, and energy consumption.

A stroboscopic imaging interferometer system includes an environmental chamber having a novel viewing window equipped with a rigidly integrated beam splitter and piezo actuated reference mirror for illuminating a device providing an object beam and reference mirror for providing a reference beam, upon the reflection of both beams, produces interference of the object beam by the reference beam for providing absolute phase observations of the device, that may be a MEMS device under test.

A photosensitive composition including a quantum dot complex having a polymeric outer layer, a carboxylic acid group-containing binder, a photopolymerizable monomer having a carbon-carbon double bond, a photoinitiator, and a solvent, wherein the polymeric outer layer includes a copolymer including:a first repeating unit having a moiety capable of interacting with a surface of the quantum dot, an organic ligand compound bonded to the surface of the quantum dot, or a combination thereof, anda second repeating unit having a reactive moiety.