The invention discloses a preparation method of a 
chronic renal failure colon dialysate for solving the treatment problem of 
chronic renal failure. The preparation method is characterized in that the preparation method comprises the following steps of: (1) performing reduced pressure 
distillation on 
ailanthus-like pricklyash 
bark, catclaw buttercup root and Chinese ephedra root coarse 
powder to extract volatile oil; (2) performing reduced pressure decoction on tall 
gastrodia tuber to obtain a filtrate; (3) performing water decoction on 
trikeraia hookeri, 
magnolia amoena, dragon's blood, 
melanoidin malt, scorch-fried medicated leaven, mimoselike 
rosewood leaf, peach gum, 
cassia twig and dregs obtained in the step (1) to obtain a filtrate for later use; (4) merging the filtrates obtained in the steps (2) and (3), performing reduced pressure concentration to obtain a dry extract, and crushing to obtain dry extract 
powder; (5) spraying the volatile oil obtained in the step (1) into the dry extract 
powder obtained in the step (4), uniformly mixing, and screening by a 100-mesh screen to obtain colon 
dialysis concentrated powder; and (6) adding ten times the volume of 
warm water into the colon 
dialysis concentrated powder obtained in the step (5) during the use, and uniformly mixing. Clinical experiments prove that by using the 
chronic renal failure colon dialysate for treating the chronic renal failure, the frequency of 
hemodialysis can be reduced, and the preparation method is further worthy of clinical application and popularization.